EA201100334A1 - Бициклические производные триазола для лечения опухолей - Google Patents

Бициклические производные триазола для лечения опухолей

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Publication number
EA201100334A1
EA201100334A1 EA201100334A EA201100334A EA201100334A1 EA 201100334 A1 EA201100334 A1 EA 201100334A1 EA 201100334 A EA201100334 A EA 201100334A EA 201100334 A EA201100334 A EA 201100334A EA 201100334 A1 EA201100334 A1 EA 201100334A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tumors
treatment
triazole
bicyclic derivatives
bicyclic
Prior art date
Application number
EA201100334A
Other languages
English (en)
Inventor
Франк Штибер
Оливер Шадт
Дитер Дорш
Андрее Блаукат
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA201100334A1 publication Critical patent/EA201100334A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Abstract

Соединения формулы (I)в которой X, X, X, X, X, R, R, R, R', R, Rи Rимеют значения, указанные в п.1, являются ингибиторами тирозинкиназ, в особенности Met киназы, и могут применяться, среди прочего, для лечения опухолей.
EA201100334A 2008-08-14 2009-07-16 Бициклические производные триазола для лечения опухолей EA201100334A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008037790A DE102008037790A1 (de) 2008-08-14 2008-08-14 Bicyclische Triazolderivate
PCT/EP2009/005172 WO2010017870A1 (de) 2008-08-14 2009-07-16 Bicyclische triazolderivate zur behandlung von tumoren

Publications (1)

Publication Number Publication Date
EA201100334A1 true EA201100334A1 (ru) 2011-08-30

Family

ID=41138729

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100334A EA201100334A1 (ru) 2008-08-14 2009-07-16 Бициклические производные триазола для лечения опухолей

Country Status (17)

Country Link
US (1) US8435986B2 (ru)
EP (1) EP2310013B1 (ru)
JP (1) JP5475778B2 (ru)
KR (1) KR20110051243A (ru)
CN (1) CN102123710B (ru)
AR (1) AR073055A1 (ru)
AU (1) AU2009281491B2 (ru)
BR (1) BRPI0914555A2 (ru)
CA (1) CA2733941C (ru)
DE (1) DE102008037790A1 (ru)
EA (1) EA201100334A1 (ru)
ES (1) ES2648233T3 (ru)
HK (1) HK1159989A1 (ru)
IL (1) IL211193A0 (ru)
MX (1) MX2011001511A (ru)
WO (1) WO2010017870A1 (ru)
ZA (1) ZA201101899B (ru)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2677696C1 (ru) * 2013-12-09 2019-01-21 Юсб Байофарма Спрл Производные бензотриазола в качестве модуляторов активности tnf

Also Published As

Publication number Publication date
KR20110051243A (ko) 2011-05-17
CA2733941A1 (en) 2010-02-18
ES2648233T3 (es) 2017-12-29
AR073055A1 (es) 2010-10-13
CA2733941C (en) 2016-10-04
AU2009281491B2 (en) 2014-02-20
MX2011001511A (es) 2011-03-15
JP2011530545A (ja) 2011-12-22
CN102123710B (zh) 2012-11-07
CN102123710A (zh) 2011-07-13
US20110135600A1 (en) 2011-06-09
DE102008037790A1 (de) 2010-02-18
AU2009281491A1 (en) 2010-02-18
US8435986B2 (en) 2013-05-07
IL211193A0 (en) 2011-04-28
HK1159989A1 (en) 2012-08-10
WO2010017870A1 (de) 2010-02-18
JP5475778B2 (ja) 2014-04-16
BRPI0914555A2 (pt) 2015-12-15
EP2310013B1 (de) 2017-08-23
ZA201101899B (en) 2011-11-30
EP2310013A1 (de) 2011-04-20

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