EA201001648A1 - Производные пиридазинона - Google Patents

Производные пиридазинона

Info

Publication number
EA201001648A1
EA201001648A1 EA201001648A EA201001648A EA201001648A1 EA 201001648 A1 EA201001648 A1 EA 201001648A1 EA 201001648 A EA201001648 A EA 201001648A EA 201001648 A EA201001648 A EA 201001648A EA 201001648 A1 EA201001648 A1 EA 201001648A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyridazinon
derivatives
compounds
formula
tyrosine kinase
Prior art date
Application number
EA201001648A
Other languages
English (en)
Other versions
EA018362B1 (ru
Inventor
Дитер Дорш
Оливер Шадт
Франк Штибер
Анрее Блаукат
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA201001648A1 publication Critical patent/EA201001648A1/ru
Publication of EA018362B1 publication Critical patent/EA018362B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Соединения формулы (I)где R, R, R, W и D имеют значения, указанные в п.1, являются ингибиторами тирозинкиназ, в особенности Met киназы, и могут применяться, в частности, для лечения опухолей.
EA201001648A 2008-04-21 2009-03-24 Производные пиридазинона EA018362B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008019907A DE102008019907A1 (de) 2008-04-21 2008-04-21 Pyridazinonderivate
PCT/EP2009/002137 WO2009129905A1 (de) 2008-04-21 2009-03-24 Pyridazinonderivate

Publications (2)

Publication Number Publication Date
EA201001648A1 true EA201001648A1 (ru) 2011-06-30
EA018362B1 EA018362B1 (ru) 2013-07-30

Family

ID=40639931

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201001648A EA018362B1 (ru) 2008-04-21 2009-03-24 Производные пиридазинона

Country Status (22)

Country Link
US (1) US8604036B2 (ru)
EP (1) EP2280962B1 (ru)
JP (1) JP5576358B2 (ru)
KR (1) KR20100137564A (ru)
CN (1) CN102015694A (ru)
AR (1) AR071208A1 (ru)
AU (1) AU2009240346B2 (ru)
BR (1) BRPI0911161B8 (ru)
CA (1) CA2721858C (ru)
CY (1) CY1113443T1 (ru)
DE (1) DE102008019907A1 (ru)
DK (1) DK2280962T5 (ru)
EA (1) EA018362B1 (ru)
ES (1) ES2394147T3 (ru)
HR (1) HRP20120884T1 (ru)
IL (1) IL208336A (ru)
MX (1) MX2010011454A (ru)
PL (1) PL2280962T3 (ru)
PT (1) PT2280962E (ru)
SI (1) SI2280962T1 (ru)
WO (1) WO2009129905A1 (ru)
ZA (1) ZA201008330B (ru)

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CN108752322A (zh) * 2018-09-12 2018-11-06 广州新民培林医药科技有限公司 一种新型Tepotinib衍生物和制备方法及其在抗肿瘤药物中的应用
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Also Published As

Publication number Publication date
PT2280962E (pt) 2012-12-17
JP5576358B2 (ja) 2014-08-20
EP2280962B1 (de) 2012-10-03
ES2394147T3 (es) 2013-01-22
ZA201008330B (en) 2011-09-28
US20110034474A1 (en) 2011-02-10
IL208336A0 (en) 2010-12-30
KR20100137564A (ko) 2010-12-30
WO2009129905A1 (de) 2009-10-29
JP2011518202A (ja) 2011-06-23
CA2721858A1 (en) 2009-10-29
CA2721858C (en) 2016-07-19
AU2009240346A1 (en) 2009-10-29
AR071208A1 (es) 2010-06-02
MX2010011454A (es) 2010-12-21
DK2280962T5 (da) 2013-09-16
CN102015694A (zh) 2011-04-13
BRPI0911161B8 (pt) 2021-05-25
HRP20120884T1 (hr) 2012-11-30
DK2280962T3 (da) 2012-11-19
SI2280962T1 (sl) 2013-01-31
BRPI0911161B1 (pt) 2020-02-11
CY1113443T1 (el) 2016-06-22
EP2280962A1 (de) 2011-02-09
AU2009240346B2 (en) 2013-10-10
EA018362B1 (ru) 2013-07-30
US8604036B2 (en) 2013-12-10
IL208336A (en) 2016-07-31
PL2280962T3 (pl) 2013-02-28
DE102008019907A1 (de) 2009-10-22
BRPI0911161A2 (pt) 2015-10-06

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM