EA200901611A1 - Производные 2-оксо-3-бензил-бензоксазол-2-она и родственные соединения в качестве ингибиторов мет киназы для лечения опухолей - Google Patents
Производные 2-оксо-3-бензил-бензоксазол-2-она и родственные соединения в качестве ингибиторов мет киназы для лечения опухолейInfo
- Publication number
- EA200901611A1 EA200901611A1 EA200901611A EA200901611A EA200901611A1 EA 200901611 A1 EA200901611 A1 EA 200901611A1 EA 200901611 A EA200901611 A EA 200901611A EA 200901611 A EA200901611 A EA 200901611A EA 200901611 A1 EA200901611 A1 EA 200901611A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- kinase inhibitors
- benzoxazol
- oxo
- meters
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
Abstract
Соединения формулы (I)в которой R, R, R, R, R, R', Е, Е', Е" и Е'" имеют значения, указанные в п.1, являются ингибиторами тирозинкиназ, в особенности Met киназы, и могут применяться, в частности, для лечения опухолей.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007026341A DE102007026341A1 (de) | 2007-06-06 | 2007-06-06 | Benzoxazolonderivate |
PCT/EP2008/003696 WO2008148449A1 (de) | 2007-06-06 | 2008-05-08 | 2-oxo-3-benzyl-benzoxazol-2-one derivate und verwandte verbindungen als met-kinase inhibitoren zur behandlung von tumoren |
Publications (1)
Publication Number | Publication Date |
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EA200901611A1 true EA200901611A1 (ru) | 2010-06-30 |
Family
ID=39739806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200901611A EA200901611A1 (ru) | 2007-06-06 | 2008-05-08 | Производные 2-оксо-3-бензил-бензоксазол-2-она и родственные соединения в качестве ингибиторов мет киназы для лечения опухолей |
Country Status (18)
Country | Link |
---|---|
US (2) | US8071593B2 (ru) |
EP (1) | EP2150551B1 (ru) |
JP (1) | JP5662143B2 (ru) |
KR (1) | KR20100031531A (ru) |
CN (1) | CN101679401B (ru) |
AR (1) | AR066892A1 (ru) |
AU (1) | AU2008258366B2 (ru) |
BR (1) | BRPI0812293A2 (ru) |
CA (1) | CA2689554C (ru) |
DE (1) | DE102007026341A1 (ru) |
EA (1) | EA200901611A1 (ru) |
ES (1) | ES2402540T3 (ru) |
IL (1) | IL202505A (ru) |
MX (1) | MX2009013077A (ru) |
PE (1) | PE20090770A1 (ru) |
TW (1) | TW200848030A (ru) |
WO (1) | WO2008148449A1 (ru) |
ZA (1) | ZA201000085B (ru) |
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DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
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DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
US9643922B2 (en) | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
EP2326631A4 (en) * | 2008-08-18 | 2012-03-21 | Univ Yale | MODULATORS OF MIF |
JP5690741B2 (ja) | 2008-12-22 | 2015-03-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 新規な多形形態の6−(1−メチル−1h−ピラゾール−4−イル)−2−{3−[5−(2−モルホリン−4−イル−エトキシ)−ピリミジン−2−イル]−ベンジル}−2h−ピリダジン−3−オンジヒドロゲンホスファートおよびその製造方法 |
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AR095883A1 (es) * | 2013-04-18 | 2015-11-18 | Astellas Pharma Inc | Compuestos de acetamida heterocíclica |
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WO2016091891A1 (en) | 2014-12-09 | 2016-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Human monoclonal antibodies against axl |
WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
KR101798840B1 (ko) | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
JP2020524718A (ja) * | 2017-06-22 | 2020-08-20 | キュラデブ・ファーマ・リミテッドCuradev Pharma Limited | ヒトstingの複素環式小分子調節因子 |
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2007
- 2007-06-06 DE DE102007026341A patent/DE102007026341A1/de not_active Withdrawn
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2008
- 2008-05-08 KR KR1020107000014A patent/KR20100031531A/ko not_active Application Discontinuation
- 2008-05-08 ES ES08749391T patent/ES2402540T3/es active Active
- 2008-05-08 US US12/663,206 patent/US8071593B2/en not_active Expired - Fee Related
- 2008-05-08 CA CA2689554A patent/CA2689554C/en active Active
- 2008-05-08 EP EP08749391A patent/EP2150551B1/de active Active
- 2008-05-08 AU AU2008258366A patent/AU2008258366B2/en not_active Ceased
- 2008-05-08 WO PCT/EP2008/003696 patent/WO2008148449A1/de active Application Filing
- 2008-05-08 CN CN2008800183950A patent/CN101679401B/zh active Active
- 2008-05-08 JP JP2010510658A patent/JP5662143B2/ja active Active
- 2008-05-08 MX MX2009013077A patent/MX2009013077A/es not_active Application Discontinuation
- 2008-05-08 BR BRPI0812293-8A2A patent/BRPI0812293A2/pt not_active IP Right Cessation
- 2008-05-08 EA EA200901611A patent/EA200901611A1/ru unknown
- 2008-06-05 PE PE2008000958A patent/PE20090770A1/es not_active Application Discontinuation
- 2008-06-06 TW TW097121279A patent/TW200848030A/zh unknown
- 2008-06-06 AR ARP080102415A patent/AR066892A1/es unknown
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2009
- 2009-12-03 IL IL202505A patent/IL202505A/en active IP Right Grant
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2010
- 2010-01-05 ZA ZA201000085A patent/ZA201000085B/xx unknown
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2011
- 2011-07-06 US US13/177,261 patent/US8431572B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2008258366B2 (en) | 2013-02-21 |
TW200848030A (en) | 2008-12-16 |
DE102007026341A1 (de) | 2008-12-11 |
AU2008258366A1 (en) | 2008-12-11 |
EP2150551B1 (de) | 2013-01-16 |
CA2689554C (en) | 2015-12-01 |
AR066892A1 (es) | 2009-09-16 |
EP2150551A1 (de) | 2010-02-10 |
CN101679401B (zh) | 2012-12-12 |
CA2689554A1 (en) | 2008-12-11 |
US8431572B2 (en) | 2013-04-30 |
BRPI0812293A2 (pt) | 2014-11-25 |
IL202505A (en) | 2014-11-30 |
PE20090770A1 (es) | 2009-06-24 |
MX2009013077A (es) | 2010-01-15 |
US20110263596A1 (en) | 2011-10-27 |
CN101679401A (zh) | 2010-03-24 |
ZA201000085B (en) | 2010-09-29 |
US8071593B2 (en) | 2011-12-06 |
IL202505A0 (en) | 2010-06-30 |
US20100280030A1 (en) | 2010-11-04 |
WO2008148449A1 (de) | 2008-12-11 |
JP2010529051A (ja) | 2010-08-26 |
JP5662143B2 (ja) | 2015-01-28 |
ES2402540T3 (es) | 2013-05-06 |
KR20100031531A (ko) | 2010-03-22 |
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