MX2009013077A - Derivados dde benzoxazolona. - Google Patents
Derivados dde benzoxazolona.Info
- Publication number
- MX2009013077A MX2009013077A MX2009013077A MX2009013077A MX2009013077A MX 2009013077 A MX2009013077 A MX 2009013077A MX 2009013077 A MX2009013077 A MX 2009013077A MX 2009013077 A MX2009013077 A MX 2009013077A MX 2009013077 A MX2009013077 A MX 2009013077A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- tumors
- treatment
- benzoxazol
- oxo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Los compuestos de la fórmula I (ver fórmula (I)) en donde R1, R2, R3, R3´, R4, R4´, E, E´, E´´ y E´´´ tienen los significados indicados en la reivindicación 1, son inhibidores de las tirosina quinasas, en especial de la Met-quinasa, y pueden utilizarse, por ejemplo, para el tratamiento de tumores.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007026341A DE102007026341A1 (de) | 2007-06-06 | 2007-06-06 | Benzoxazolonderivate |
PCT/EP2008/003696 WO2008148449A1 (de) | 2007-06-06 | 2008-05-08 | 2-oxo-3-benzyl-benzoxazol-2-one derivate und verwandte verbindungen als met-kinase inhibitoren zur behandlung von tumoren |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009013077A true MX2009013077A (es) | 2010-01-15 |
Family
ID=39739806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009013077A MX2009013077A (es) | 2007-06-06 | 2008-05-08 | Derivados dde benzoxazolona. |
Country Status (18)
Country | Link |
---|---|
US (2) | US8071593B2 (es) |
EP (1) | EP2150551B1 (es) |
JP (1) | JP5662143B2 (es) |
KR (1) | KR20100031531A (es) |
CN (1) | CN101679401B (es) |
AR (1) | AR066892A1 (es) |
AU (1) | AU2008258366B2 (es) |
BR (1) | BRPI0812293A2 (es) |
CA (1) | CA2689554C (es) |
DE (1) | DE102007026341A1 (es) |
EA (1) | EA200901611A1 (es) |
ES (1) | ES2402540T3 (es) |
IL (1) | IL202505A (es) |
MX (1) | MX2009013077A (es) |
PE (1) | PE20090770A1 (es) |
TW (1) | TW200848030A (es) |
WO (1) | WO2008148449A1 (es) |
ZA (1) | ZA201000085B (es) |
Families Citing this family (25)
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DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
DE102007038957A1 (de) * | 2007-08-17 | 2009-02-19 | Merck Patent Gmbh | 6-Thioxo-pyridazinderivate |
DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
DE102008019907A1 (de) * | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
MX2010012528A (es) * | 2008-05-22 | 2010-12-02 | Amgen Inc | Heterociclos como inhibidores de proteina cinasa. |
DE102008028905A1 (de) * | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
US20120040974A1 (en) * | 2008-08-18 | 2012-02-16 | Yale University | Mif modulators |
US9643922B2 (en) | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
JP5690741B2 (ja) | 2008-12-22 | 2015-03-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 新規な多形形態の6−(1−メチル−1h−ピラゾール−4−イル)−2−{3−[5−(2−モルホリン−4−イル−エトキシ)−ピリミジン−2−イル]−ベンジル}−2h−ピリダジン−3−オンジヒドロゲンホスファートおよびその製造方法 |
DE102009003975A1 (de) * | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Benzothiazolonderivate |
EP2588107A1 (en) | 2010-07-01 | 2013-05-08 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
AU2012275499A1 (en) | 2011-06-27 | 2013-12-19 | Kyorin Pharmaceutical Co., Ltd. | Bridged bicyclic compounds for the treatment of bacterial infections |
CN103242345B (zh) * | 2012-09-14 | 2015-03-11 | 日出实业集团有限公司 | 甲基吡啶磷中间体6-氯噁唑[4,5-b]吡啶-2(3H)酮的合成方法 |
AR095883A1 (es) * | 2013-04-18 | 2015-11-18 | Astellas Pharma Inc | Compuestos de acetamida heterocíclica |
US9549988B2 (en) | 2013-06-09 | 2017-01-24 | RJS Biologics | Pharmaceutical compounds targeted by MIF affinity-tethered moieties |
WO2016091891A1 (en) | 2014-12-09 | 2016-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Human monoclonal antibodies against axl |
WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
KR101798840B1 (ko) | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
EP3642197A1 (en) * | 2017-06-22 | 2020-04-29 | Curadev Pharma Limited | Heterocyclic small molecule modulators of human sting |
US11180480B2 (en) | 2017-10-17 | 2021-11-23 | Sensorion | Synthesis of 4-aminopyrimidine compounds |
US20220151991A1 (en) | 2019-03-14 | 2022-05-19 | Board Of Regents, The University Of Texas System | Small molecule grb2 stabilizers for ras map kinase inhibition |
CN115490578B (zh) * | 2022-09-23 | 2023-12-22 | 江苏理工学院 | 一种碳同位素标记的三氯生的制备方法 |
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-
2007
- 2007-06-06 DE DE102007026341A patent/DE102007026341A1/de not_active Withdrawn
-
2008
- 2008-05-08 MX MX2009013077A patent/MX2009013077A/es not_active Application Discontinuation
- 2008-05-08 EP EP08749391A patent/EP2150551B1/de not_active Not-in-force
- 2008-05-08 CA CA2689554A patent/CA2689554C/en active Active
- 2008-05-08 AU AU2008258366A patent/AU2008258366B2/en not_active Ceased
- 2008-05-08 BR BRPI0812293-8A2A patent/BRPI0812293A2/pt not_active IP Right Cessation
- 2008-05-08 ES ES08749391T patent/ES2402540T3/es active Active
- 2008-05-08 US US12/663,206 patent/US8071593B2/en not_active Expired - Fee Related
- 2008-05-08 WO PCT/EP2008/003696 patent/WO2008148449A1/de active Application Filing
- 2008-05-08 CN CN2008800183950A patent/CN101679401B/zh not_active Expired - Fee Related
- 2008-05-08 EA EA200901611A patent/EA200901611A1/ru unknown
- 2008-05-08 KR KR1020107000014A patent/KR20100031531A/ko not_active Application Discontinuation
- 2008-05-08 JP JP2010510658A patent/JP5662143B2/ja not_active Expired - Fee Related
- 2008-06-05 PE PE2008000958A patent/PE20090770A1/es not_active Application Discontinuation
- 2008-06-06 AR ARP080102415A patent/AR066892A1/es unknown
- 2008-06-06 TW TW097121279A patent/TW200848030A/zh unknown
-
2009
- 2009-12-03 IL IL202505A patent/IL202505A/en active IP Right Grant
-
2010
- 2010-01-05 ZA ZA201000085A patent/ZA201000085B/xx unknown
-
2011
- 2011-07-06 US US13/177,261 patent/US8431572B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR20100031531A (ko) | 2010-03-22 |
AU2008258366B2 (en) | 2013-02-21 |
JP5662143B2 (ja) | 2015-01-28 |
BRPI0812293A2 (pt) | 2014-11-25 |
US8431572B2 (en) | 2013-04-30 |
US20100280030A1 (en) | 2010-11-04 |
IL202505A0 (en) | 2010-06-30 |
CN101679401B (zh) | 2012-12-12 |
TW200848030A (en) | 2008-12-16 |
US20110263596A1 (en) | 2011-10-27 |
IL202505A (en) | 2014-11-30 |
WO2008148449A1 (de) | 2008-12-11 |
AU2008258366A1 (en) | 2008-12-11 |
US8071593B2 (en) | 2011-12-06 |
CA2689554C (en) | 2015-12-01 |
AR066892A1 (es) | 2009-09-16 |
PE20090770A1 (es) | 2009-06-24 |
EP2150551B1 (de) | 2013-01-16 |
ZA201000085B (en) | 2010-09-29 |
DE102007026341A1 (de) | 2008-12-11 |
EA200901611A1 (ru) | 2010-06-30 |
EP2150551A1 (de) | 2010-02-10 |
CN101679401A (zh) | 2010-03-24 |
CA2689554A1 (en) | 2008-12-11 |
JP2010529051A (ja) | 2010-08-26 |
ES2402540T3 (es) | 2013-05-06 |
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