MX2009013077A - Derivados dde benzoxazolona. - Google Patents

Derivados dde benzoxazolona.

Info

Publication number
MX2009013077A
MX2009013077A MX2009013077A MX2009013077A MX2009013077A MX 2009013077 A MX2009013077 A MX 2009013077A MX 2009013077 A MX2009013077 A MX 2009013077A MX 2009013077 A MX2009013077 A MX 2009013077A MX 2009013077 A MX2009013077 A MX 2009013077A
Authority
MX
Mexico
Prior art keywords
sup
tumors
treatment
benzoxazol
oxo
Prior art date
Application number
MX2009013077A
Other languages
English (en)
Inventor
Dieter Dorsch
Oliver Schadt
Frank Stieber
Andree Blaukat
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2009013077A publication Critical patent/MX2009013077A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Los compuestos de la fórmula I (ver fórmula (I)) en donde R1, R2, R3, R3´, R4, R4´, E, E´, E´´ y E´´´ tienen los significados indicados en la reivindicación 1, son inhibidores de las tirosina quinasas, en especial de la Met-quinasa, y pueden utilizarse, por ejemplo, para el tratamiento de tumores.
MX2009013077A 2007-06-06 2008-05-08 Derivados dde benzoxazolona. MX2009013077A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007026341A DE102007026341A1 (de) 2007-06-06 2007-06-06 Benzoxazolonderivate
PCT/EP2008/003696 WO2008148449A1 (de) 2007-06-06 2008-05-08 2-oxo-3-benzyl-benzoxazol-2-one derivate und verwandte verbindungen als met-kinase inhibitoren zur behandlung von tumoren

Publications (1)

Publication Number Publication Date
MX2009013077A true MX2009013077A (es) 2010-01-15

Family

ID=39739806

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013077A MX2009013077A (es) 2007-06-06 2008-05-08 Derivados dde benzoxazolona.

Country Status (18)

Country Link
US (2) US8071593B2 (es)
EP (1) EP2150551B1 (es)
JP (1) JP5662143B2 (es)
KR (1) KR20100031531A (es)
CN (1) CN101679401B (es)
AR (1) AR066892A1 (es)
AU (1) AU2008258366B2 (es)
BR (1) BRPI0812293A2 (es)
CA (1) CA2689554C (es)
DE (1) DE102007026341A1 (es)
EA (1) EA200901611A1 (es)
ES (1) ES2402540T3 (es)
IL (1) IL202505A (es)
MX (1) MX2009013077A (es)
PE (1) PE20090770A1 (es)
TW (1) TW200848030A (es)
WO (1) WO2008148449A1 (es)
ZA (1) ZA201000085B (es)

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CN115490578B (zh) * 2022-09-23 2023-12-22 江苏理工学院 一种碳同位素标记的三氯生的制备方法

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Also Published As

Publication number Publication date
KR20100031531A (ko) 2010-03-22
AU2008258366B2 (en) 2013-02-21
JP5662143B2 (ja) 2015-01-28
BRPI0812293A2 (pt) 2014-11-25
US8431572B2 (en) 2013-04-30
US20100280030A1 (en) 2010-11-04
IL202505A0 (en) 2010-06-30
CN101679401B (zh) 2012-12-12
TW200848030A (en) 2008-12-16
US20110263596A1 (en) 2011-10-27
IL202505A (en) 2014-11-30
WO2008148449A1 (de) 2008-12-11
AU2008258366A1 (en) 2008-12-11
US8071593B2 (en) 2011-12-06
CA2689554C (en) 2015-12-01
AR066892A1 (es) 2009-09-16
PE20090770A1 (es) 2009-06-24
EP2150551B1 (de) 2013-01-16
ZA201000085B (en) 2010-09-29
DE102007026341A1 (de) 2008-12-11
EA200901611A1 (ru) 2010-06-30
EP2150551A1 (de) 2010-02-10
CN101679401A (zh) 2010-03-24
CA2689554A1 (en) 2008-12-11
JP2010529051A (ja) 2010-08-26
ES2402540T3 (es) 2013-05-06

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