AR095883A1 - Compuestos de acetamida heterocíclica - Google Patents
Compuestos de acetamida heterocíclicaInfo
- Publication number
- AR095883A1 AR095883A1 ARP140101624A ARP140101624A AR095883A1 AR 095883 A1 AR095883 A1 AR 095883A1 AR P140101624 A ARP140101624 A AR P140101624A AR P140101624 A ARP140101624 A AR P140101624A AR 095883 A1 AR095883 A1 AR 095883A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- halogen
- disease
- compound
- dopamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Abstract
Un compuesto que tiene actividad moduladora alostérica positiva de un receptor de dopamina D1 y es útil como principio activo de una composición farmacéutica para la prevención y/o el tratamiento de la discapacidad intelectual, síntomas negativos de la esquizofrenia, enfermedad de Parkinson, enfermedad de Alzheimer, enfermedad de Huntington, adicciones a las drogas, u otros similares, y de este modo han encontrado que un compuesto de acetamida heterocíclica tiene actividad moduladora alostérica positiva de un receptor de dopamina D1, completando de este modo la presente. El compuesto de acetamida heterocíclica de la presente tiene actividad moduladora alostérica positiva de un receptor de dopamina D1 y puede usarse como un agente para la prevencion y/o el tratamiento de la discapacidad intelectual, síntomas negativos de la esquizofrenia, enfermedad de Parkinson, enfermedad de Alzheimer, enfermedad de Huntington, adicciones a las drogas, u otros similares. Reivindicación 1: Un compuesto de la fórmula (1) o una de sus sales, (donde el anillo A es un anillo de benceno; R¹ es alquilo inferior, halógeno, halógeno-alquilo inferior o -O-halógeno-alquilo inferior; R² es H o halógeno; R¹¹, R¹², R¹³ y R¹⁴ son iguales o diferentes entre sí, y son H, alquilo inferior, halógeno, halógeno-alquilo inferior, cicloalquilo, -O-alquilo inferior o -O-halógeno-alquilo inferior; U es NR¹⁵ u O; V es CH o N, en el caso donde U es O, V es N; R¹⁵ es H, alquilo inferior, o -alquileno inferior-OH; y X es O).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013087151 | 2013-04-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR095883A1 true AR095883A1 (es) | 2015-11-18 |
Family
ID=51729480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140101624A AR095883A1 (es) | 2013-04-18 | 2014-04-16 | Compuestos de acetamida heterocíclica |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US8937087B2 (es) |
| EP (1) | EP2987793B1 (es) |
| JP (1) | JP6252582B2 (es) |
| KR (1) | KR102193247B1 (es) |
| CN (1) | CN105121435B (es) |
| AR (1) | AR095883A1 (es) |
| AU (1) | AU2014254768B2 (es) |
| BR (1) | BR112015026512B1 (es) |
| CA (1) | CA2909783C (es) |
| CY (1) | CY1119754T1 (es) |
| DK (1) | DK2987793T3 (es) |
| EA (1) | EA028968B1 (es) |
| ES (1) | ES2651866T3 (es) |
| HK (1) | HK1214248A1 (es) |
| HR (1) | HRP20171786T1 (es) |
| HU (1) | HUE036054T2 (es) |
| IL (1) | IL241962B (es) |
| LT (1) | LT2987793T (es) |
| ME (1) | ME02891B (es) |
| MX (1) | MX2015014646A (es) |
| MY (1) | MY175971A (es) |
| NO (1) | NO2987793T3 (es) |
| NZ (1) | NZ713118A (es) |
| PH (1) | PH12015502341A1 (es) |
| PL (1) | PL2987793T3 (es) |
| PT (1) | PT2987793T (es) |
| RS (1) | RS56865B1 (es) |
| SA (1) | SA515370015B1 (es) |
| SG (1) | SG11201508448RA (es) |
| SI (1) | SI2987793T1 (es) |
| TW (1) | TWI625329B (es) |
| UA (1) | UA116243C2 (es) |
| WO (1) | WO2014171528A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR105025A1 (es) * | 2015-06-19 | 2017-08-30 | Astellas Pharma Inc | Compuesto de imidazodiazepina |
| TWI725408B (zh) | 2018-04-20 | 2021-04-21 | 美商美國禮來大藥廠 | 多巴胺d1受體正向異位調節劑 |
| CN112912377A (zh) | 2018-09-13 | 2021-06-04 | 拜耳公司 | 作为害虫防治剂的杂环衍生物 |
| CN110590576A (zh) * | 2019-08-15 | 2019-12-20 | 安徽金禾实业股份有限公司 | 一种4-多氟代甲氧基邻苯二胺的制备方法 |
| CN114380709B (zh) * | 2021-12-31 | 2023-07-21 | 西北农林科技大学 | 4-氯-2-酰氨基酚的合成方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2674524B1 (fr) * | 1991-03-25 | 1993-05-21 | Adir | Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| BR0009539A (pt) | 1999-04-02 | 2006-06-06 | Neurogen Corp | composto, composição farmacêutica, método para tratamento ou prevenção de uma doença ou distúrbio associado com agonismo patogênico, agonismo inverso ou antagonismo do receptor gaba a, uso de um composto, método para localizar receptores gaba a em uma amostra de tecido, método para alterar a atividade transdutora de sinal de receptores gaba a, método para o tratamento ou prevenção de distúrbios psicológicos associados com modulação do complexo receptor gaba a, e, processo para a preparação de um composto |
| US6627624B1 (en) | 1999-04-02 | 2003-09-30 | Neurogen Corporation | Aryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors |
| US6380210B1 (en) | 1999-04-02 | 2002-04-30 | Neurogen Corporation | Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors |
| AUPQ309399A0 (en) | 1999-09-28 | 1999-10-21 | Fujisawa Pharmaceutical Co., Ltd. | Benzothiazoline derivatives |
| EP1434765B1 (en) | 2001-09-14 | 2009-12-02 | High Point Pharmaceuticals, LLC | Substituted piperidines with selective binding to histamine h3-receptor |
| US7361671B2 (en) | 2001-11-15 | 2008-04-22 | The Institute For Pharmaceutical Discovery, Inc. | Substituted heteroarylalkanoic acids |
| CA2478183C (en) | 2002-03-12 | 2010-02-16 | Merck & Co. Inc. | Substituted amides |
| CA2519475A1 (en) | 2003-03-14 | 2004-09-30 | Merck & Co., Inc. | Bicyclic anilide spirohydantoin cgrp receptor antagonists |
| CA2554774A1 (en) * | 2004-02-23 | 2005-09-01 | Dainippon Sumitomo Pharma Co., Ltd. | Novel heterocyclic compound |
| CA2567909A1 (en) | 2004-05-27 | 2005-12-15 | Ucb, S.A. | Benzoxazolone derivatives, processes for preparing them and their uses |
| US7790726B2 (en) | 2005-08-16 | 2010-09-07 | Chemocentryx, Inc. | Monocyclic and bicyclic compounds and methods of use |
| US7576218B2 (en) | 2005-10-11 | 2009-08-18 | Chemocentryx, Inc. | 4-phenylpiperdine-pyrazole CCR1 antagonists |
| CL2007002097A1 (es) | 2006-07-20 | 2008-01-18 | Smithkline Beecham Corp | Compuestos derivados de pirrolidina o morfolina antagonistas de urotensina ii; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar insuficiencia cardiaca congestiva, insuficiencia cardiaca isquemica, angina, isquemia del miocardio, vejiga hiperactiva, asma y/o copd, entre otras. |
| US7786157B2 (en) | 2007-03-16 | 2010-08-31 | Chemocentryx, Inc. | OXO-imidazolidines as modulators of chemokine receptors |
| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| GB0713686D0 (en) * | 2007-07-13 | 2007-08-22 | Addex Pharmaceuticals Sa | New compounds 2 |
-
2014
- 2014-04-16 AR ARP140101624A patent/AR095883A1/es active IP Right Grant
- 2014-04-17 TW TW103114022A patent/TWI625329B/zh active
- 2014-04-18 DK DK14786115.7T patent/DK2987793T3/en active
- 2014-04-18 AU AU2014254768A patent/AU2014254768B2/en active Active
- 2014-04-18 JP JP2015512531A patent/JP6252582B2/ja active Active
- 2014-04-18 US US14/256,135 patent/US8937087B2/en active Active
- 2014-04-18 MY MYPI2015703694A patent/MY175971A/en unknown
- 2014-04-18 EP EP14786115.7A patent/EP2987793B1/en active Active
- 2014-04-18 MX MX2015014646A patent/MX2015014646A/es active IP Right Grant
- 2014-04-18 CA CA2909783A patent/CA2909783C/en active Active
- 2014-04-18 WO PCT/JP2014/061007 patent/WO2014171528A1/ja active Application Filing
- 2014-04-18 ME MEP-2017-277A patent/ME02891B/me unknown
- 2014-04-18 BR BR112015026512-0A patent/BR112015026512B1/pt active IP Right Grant
- 2014-04-18 NZ NZ713118A patent/NZ713118A/en unknown
- 2014-04-18 PL PL14786115T patent/PL2987793T3/pl unknown
- 2014-04-18 LT LTEP14786115.7T patent/LT2987793T/lt unknown
- 2014-04-18 UA UAA201511337A patent/UA116243C2/uk unknown
- 2014-04-18 KR KR1020157027691A patent/KR102193247B1/ko active IP Right Grant
- 2014-04-18 HU HUE14786115A patent/HUE036054T2/hu unknown
- 2014-04-18 RS RS20171324A patent/RS56865B1/sr unknown
- 2014-04-18 SI SI201430479T patent/SI2987793T1/en unknown
- 2014-04-18 SG SG11201508448RA patent/SG11201508448RA/en unknown
- 2014-04-18 NO NO14786115A patent/NO2987793T3/no unknown
- 2014-04-18 CN CN201480020846.XA patent/CN105121435B/zh active Active
- 2014-04-18 EA EA201591988A patent/EA028968B1/ru not_active IP Right Cessation
- 2014-04-18 ES ES14786115.7T patent/ES2651866T3/es active Active
- 2014-04-18 PT PT147861157T patent/PT2987793T/pt unknown
- 2014-10-28 US US14/525,982 patent/US9708307B2/en active Active
-
2015
- 2015-10-07 IL IL241962A patent/IL241962B/en active IP Right Grant
- 2015-10-08 PH PH12015502341A patent/PH12015502341A1/en unknown
- 2015-10-18 SA SA515370015A patent/SA515370015B1/ar unknown
-
2016
- 2016-02-23 HK HK16102028.4A patent/HK1214248A1/zh unknown
-
2017
- 2017-11-17 HR HRP20171786TT patent/HRP20171786T1/hr unknown
- 2017-12-06 CY CY20171101288T patent/CY1119754T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |