CY1119754T1 - Ετεροκυκλικη ενωση αμιδιου οξικου οξεος - Google Patents
Ετεροκυκλικη ενωση αμιδιου οξικου οξεοςInfo
- Publication number
- CY1119754T1 CY1119754T1 CY20171101288T CY171101288T CY1119754T1 CY 1119754 T1 CY1119754 T1 CY 1119754T1 CY 20171101288 T CY20171101288 T CY 20171101288T CY 171101288 T CY171101288 T CY 171101288T CY 1119754 T1 CY1119754 T1 CY 1119754T1
- Authority
- CY
- Cyprus
- Prior art keywords
- disease
- dopamine
- acetic acid
- positive allosteric
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Abstract
[Πρόβλημα] Θα παρασχεθεί μια ένωση του Χημικού Τύπου (I) που να είναι χρήσιμη ως ένας θετικός αλλοστερικός διαμορφωτής υποδοχέα δοπαμίνης D1 (D1 ΡΑΜ). [Λύση] Οι εφευρέτες μελέτησαν μια ένωση που έχει μία δράση θετικής αλλοστερικής διαμόρφωσης υποδοχέα δοπαμίνης D1 και που είναι χρήσιμη ως ένα ενεργό συστατικό μίγματος για μια φαρμακευτική σύνθεση για πρόληψη και/ή αγωγή γνωσιακής δυσλειτουργίας, αρνητικών συμπτωμάτων σχιζοφρένειας, νόσο του Πάρκινσον, νόσο του Αλτσχάϊμερ, νόσο του Χάντινγκτον, εξάρτησης φαρμάκων κλπ, έχουν επιβεβαιώσει ότι μία ετεροκυκλική ένωση αμιδίου οξικού οξέος έχει μια δράση θετικής αλλοστερικής διαμόρφωσης υποδοχέα δοπαμίνης D1, και έχουν συμπληρώσει την παρούσα εφεύρεση. Αυτή η ετεροκυκλική ένωση αμιδίου οξικού οξέος έχει μια δράση θετικής αλλοστερικής διαμόρφωσης υποδοχέα δοπαμίνης D1 και μπορεί να χρησιμοποιηθεί ως ένας προληπτικός και/ή θεραπευτικός παράγων για γνωσιακή δυσλειτουργία, αρνητικά συμπτώματα σχιζοφρένειας, νόσο του Πάρκινσον, νόσο του Αλτσχάϊμερ, νόσο του Χάντινγκτον, εξάρτησης φαρμάκων, κλπ.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013087151 | 2013-04-18 | ||
| PCT/JP2014/061007 WO2014171528A1 (ja) | 2013-04-18 | 2014-04-18 | ヘテロ環酢酸アミド化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119754T1 true CY1119754T1 (el) | 2018-06-27 |
Family
ID=51729480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171101288T CY1119754T1 (el) | 2013-04-18 | 2017-12-06 | Ετεροκυκλικη ενωση αμιδιου οξικου οξεος |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US8937087B2 (el) |
| EP (1) | EP2987793B1 (el) |
| JP (1) | JP6252582B2 (el) |
| KR (1) | KR102193247B1 (el) |
| CN (1) | CN105121435B (el) |
| AR (1) | AR095883A1 (el) |
| AU (1) | AU2014254768B2 (el) |
| BR (1) | BR112015026512B1 (el) |
| CA (1) | CA2909783C (el) |
| CY (1) | CY1119754T1 (el) |
| DK (1) | DK2987793T3 (el) |
| EA (1) | EA028968B1 (el) |
| ES (1) | ES2651866T3 (el) |
| HK (1) | HK1214248A1 (el) |
| HR (1) | HRP20171786T1 (el) |
| HU (1) | HUE036054T2 (el) |
| IL (1) | IL241962B (el) |
| LT (1) | LT2987793T (el) |
| ME (1) | ME02891B (el) |
| MX (1) | MX2015014646A (el) |
| MY (1) | MY175971A (el) |
| NO (1) | NO2987793T3 (el) |
| NZ (1) | NZ713118A (el) |
| PH (1) | PH12015502341B1 (el) |
| PL (1) | PL2987793T3 (el) |
| PT (1) | PT2987793T (el) |
| RS (1) | RS56865B1 (el) |
| SA (1) | SA515370015B1 (el) |
| SG (1) | SG11201508448RA (el) |
| SI (1) | SI2987793T1 (el) |
| TW (1) | TWI625329B (el) |
| UA (1) | UA116243C2 (el) |
| WO (1) | WO2014171528A1 (el) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR105025A1 (es) * | 2015-06-19 | 2017-08-30 | Astellas Pharma Inc | Compuesto de imidazodiazepina |
| TWI725408B (zh) | 2018-04-20 | 2021-04-21 | 美商美國禮來大藥廠 | 多巴胺d1受體正向異位調節劑 |
| WO2020053282A1 (de) | 2018-09-13 | 2020-03-19 | Bayer Aktiengesellschaft | Heterocyclen-derivate als schädlingsbekämpfungsmittel |
| CN110590576A (zh) * | 2019-08-15 | 2019-12-20 | 安徽金禾实业股份有限公司 | 一种4-多氟代甲氧基邻苯二胺的制备方法 |
| CN114380709B (zh) * | 2021-12-31 | 2023-07-21 | 西北农林科技大学 | 4-氯-2-酰氨基酚的合成方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2674524B1 (fr) * | 1991-03-25 | 1993-05-21 | Adir | Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US6380210B1 (en) | 1999-04-02 | 2002-04-30 | Neurogen Corporation | Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors |
| CA2369557A1 (en) * | 1999-04-02 | 2000-10-12 | Neurogen Corporation | Aryl and heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of gabaa receptors |
| US6627624B1 (en) | 1999-04-02 | 2003-09-30 | Neurogen Corporation | Aryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors |
| AUPQ309399A0 (en) | 1999-09-28 | 1999-10-21 | Fujisawa Pharmaceutical Co., Ltd. | Benzothiazoline derivatives |
| DE60234616D1 (de) | 2001-09-14 | 2010-01-14 | High Point Pharmaceuticals Llc | Substituierte piperidinen mit selektiver bindungsfähigkeit zu histamin h3-rezeptoren |
| US7361671B2 (en) | 2001-11-15 | 2008-04-22 | The Institute For Pharmaceutical Discovery, Inc. | Substituted heteroarylalkanoic acids |
| WO2003077847A2 (en) | 2002-03-12 | 2003-09-25 | Merck & Co., Inc. | Substituted amides |
| CA2519475A1 (en) | 2003-03-14 | 2004-09-30 | Merck & Co., Inc. | Bicyclic anilide spirohydantoin cgrp receptor antagonists |
| CN1922141A (zh) * | 2004-02-23 | 2007-02-28 | 大日本住友制药株式会社 | 新的杂环化合物 |
| ES2332597T3 (es) | 2004-05-27 | 2010-02-09 | Ucb Pharma S.A. | Derivados de benzoxazolona, procedimientos para su preparacion y su uso. |
| US7790726B2 (en) | 2005-08-16 | 2010-09-07 | Chemocentryx, Inc. | Monocyclic and bicyclic compounds and methods of use |
| US7576106B2 (en) | 2005-10-11 | 2009-08-18 | Chemocentryx, Inc. | Piperidine derivatives and methods of use |
| CL2007002097A1 (es) * | 2006-07-20 | 2008-01-18 | Smithkline Beecham Corp | Compuestos derivados de pirrolidina o morfolina antagonistas de urotensina ii; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar insuficiencia cardiaca congestiva, insuficiencia cardiaca isquemica, angina, isquemia del miocardio, vejiga hiperactiva, asma y/o copd, entre otras. |
| US7786157B2 (en) | 2007-03-16 | 2010-08-31 | Chemocentryx, Inc. | OXO-imidazolidines as modulators of chemokine receptors |
| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| GB0713686D0 (en) * | 2007-07-13 | 2007-08-22 | Addex Pharmaceuticals Sa | New compounds 2 |
-
2014
- 2014-04-16 AR ARP140101624A patent/AR095883A1/es active IP Right Grant
- 2014-04-17 TW TW103114022A patent/TWI625329B/zh active
- 2014-04-18 MY MYPI2015703694A patent/MY175971A/en unknown
- 2014-04-18 NO NO14786115A patent/NO2987793T3/no unknown
- 2014-04-18 PL PL14786115T patent/PL2987793T3/pl unknown
- 2014-04-18 MX MX2015014646A patent/MX2015014646A/es active IP Right Grant
- 2014-04-18 JP JP2015512531A patent/JP6252582B2/ja active Active
- 2014-04-18 KR KR1020157027691A patent/KR102193247B1/ko active IP Right Grant
- 2014-04-18 SI SI201430479T patent/SI2987793T1/en unknown
- 2014-04-18 SG SG11201508448RA patent/SG11201508448RA/en unknown
- 2014-04-18 CN CN201480020846.XA patent/CN105121435B/zh active Active
- 2014-04-18 HU HUE14786115A patent/HUE036054T2/hu unknown
- 2014-04-18 AU AU2014254768A patent/AU2014254768B2/en active Active
- 2014-04-18 BR BR112015026512-0A patent/BR112015026512B1/pt active IP Right Grant
- 2014-04-18 ES ES14786115.7T patent/ES2651866T3/es active Active
- 2014-04-18 ME MEP-2017-277A patent/ME02891B/me unknown
- 2014-04-18 CA CA2909783A patent/CA2909783C/en active Active
- 2014-04-18 US US14/256,135 patent/US8937087B2/en active Active
- 2014-04-18 RS RS20171324A patent/RS56865B1/sr unknown
- 2014-04-18 DK DK14786115.7T patent/DK2987793T3/en active
- 2014-04-18 PT PT147861157T patent/PT2987793T/pt unknown
- 2014-04-18 UA UAA201511337A patent/UA116243C2/uk unknown
- 2014-04-18 LT LTEP14786115.7T patent/LT2987793T/lt unknown
- 2014-04-18 EA EA201591988A patent/EA028968B1/ru not_active IP Right Cessation
- 2014-04-18 WO PCT/JP2014/061007 patent/WO2014171528A1/ja active Application Filing
- 2014-04-18 EP EP14786115.7A patent/EP2987793B1/en active Active
- 2014-04-18 NZ NZ713118A patent/NZ713118A/en unknown
- 2014-10-28 US US14/525,982 patent/US9708307B2/en active Active
-
2015
- 2015-10-07 IL IL241962A patent/IL241962B/en active IP Right Grant
- 2015-10-08 PH PH12015502341A patent/PH12015502341B1/en unknown
- 2015-10-18 SA SA515370015A patent/SA515370015B1/ar unknown
-
2016
- 2016-02-23 HK HK16102028.4A patent/HK1214248A1/zh unknown
-
2017
- 2017-11-17 HR HRP20171786TT patent/HRP20171786T1/hr unknown
- 2017-12-06 CY CY20171101288T patent/CY1119754T1/el unknown
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