NI201600161A - Compuestos heteroaromáticos y su uso como ligandos de dopamina d1 - Google Patents

Compuestos heteroaromáticos y su uso como ligandos de dopamina d1

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Publication number
NI201600161A
NI201600161A NI201600161A NI201600161A NI201600161A NI 201600161 A NI201600161 A NI 201600161A NI 201600161 A NI201600161 A NI 201600161A NI 201600161 A NI201600161 A NI 201600161A NI 201600161 A NI201600161 A NI 201600161A
Authority
NI
Nicaragua
Prior art keywords
compounds
dopamine
ligands
schizophrenia
preparation
Prior art date
Application number
NI201600161A
Other languages
English (en)
Inventor
Lawrence Firman Gray David
Zhang Lei
Aaron Brodney Michael
Eric Green Michael
Subramanyam Chakrapani
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53276921&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NI201600161(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of NI201600161A publication Critical patent/NI201600161A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

La presente invención proporciona, en parte, compuestos de la Fórmula I: y las sales de estos aceptables desde el punto de vista farmacéutico; procesos para la preparación de; intermediarios usados en la preparación de; y composiciones que contienen estos compuestos o sales, y sus usos para tratar trastornos mediados por D1 (o asociados a D1) que incluyen, por ejemplo, esquizofrenia (por ejemplo, sus síntomas cognitivos y negativos), trastorno esquizotípico de la personalidad, deficiencia cognitiva (por ejemplo, deficiencia cognitiva asociada a esquizofrenia, AD, PD o tratamiento de farmacoterapia), ADHD, enfermedad de Parkinson, ansiedad y depresión.
NI201600161A 2014-04-25 2016-10-21 Compuestos heteroaromáticos y su uso como ligandos de dopamina d1 NI201600161A (es)

Applications Claiming Priority (1)

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US201461984079P 2014-04-25 2014-04-25

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NI201600161A true NI201600161A (es) 2016-11-25

Family

ID=53276921

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201600161A NI201600161A (es) 2014-04-25 2016-10-21 Compuestos heteroaromáticos y su uso como ligandos de dopamina d1

Country Status (26)

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US (2) US9540352B2 (es)
EP (1) EP3134404A1 (es)
JP (1) JP6239149B2 (es)
KR (1) KR20160142402A (es)
CN (1) CN107074843A (es)
AP (1) AP2016009512A0 (es)
AU (1) AU2015249497A1 (es)
BR (1) BR112016023740A2 (es)
CA (1) CA2946475A1 (es)
CL (1) CL2016002677A1 (es)
CR (1) CR20160494A (es)
CU (1) CU20160156A7 (es)
DO (1) DOP2016000289A (es)
EA (1) EA201691788A1 (es)
IL (1) IL248132A0 (es)
MA (1) MA39914A (es)
MD (1) MD20160109A2 (es)
MX (1) MX2016013969A (es)
NI (1) NI201600161A (es)
PE (1) PE20170009A1 (es)
PH (1) PH12016501993A1 (es)
SG (1) SG11201608468TA (es)
SV (1) SV2016005305A (es)
TN (1) TN2016000447A1 (es)
TW (1) TWI561517B (es)
WO (1) WO2015162516A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9868744B2 (en) 2014-04-25 2018-01-16 Pfizer Inc. Heteroaromatic compounds and their use as dopamine D1 ligands
EA201691831A1 (ru) * 2014-04-25 2017-02-28 Пфайзер Инк. Гетероароматические соединения и их применение в качестве допаминовых d1 лигандов
US9856263B2 (en) 2014-04-28 2018-01-02 Pfizer Inc. Heteroaromatic compounds and their use as dopamine D1 ligands
EP3137469B1 (en) 2014-04-28 2019-10-09 Pfizer Inc Heterocyclic compounds and their use as dopamine d1 ligands
BR112019013593A2 (pt) 2016-12-28 2020-01-07 Minoryx Therapeutics S.L. Compostos de isoquinolina, métodos para sua preparação, e usos terapêuticos dos mesmos em afecções associadas à alteração da atividade de beta galactosidase

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63145272A (ja) * 1986-12-09 1988-06-17 Morishita Seiyaku Kk ４，５−ジヒドロ−６−（４−置換フエニル）−３（２ｈ）−ピリダジノン誘導体
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035298A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Chewing gum containing medicament active agents
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
EP1326863A2 (en) * 2000-09-22 2003-07-16 Ortho-McNeil Pharmaceutical, Inc. Octahydro-indolizines and quinolizines and hexahydro-pyrrolizines
EP1746096A1 (en) 2005-07-15 2007-01-24 4Sc Ag 2-Arylbenzothiazole analogues and uses thereof in the treatment of cancer
JP2009501164A (ja) * 2005-07-15 2009-01-15 ４エスツェー アクチェンゲゼルシャフト ２−アリールベンゾチアゾール及びその使用
JP2010509392A (ja) * 2006-11-13 2010-03-25 ファイザー・プロダクツ・インク ジアリール、ジピリジニルおよびアリール−ピリジニル誘導体ならびにその使用
EP2367428B1 (en) * 2008-12-06 2016-04-06 Intra-Cellular Therapies, Inc. Organic compounds
US20110288090A1 (en) * 2009-02-02 2011-11-24 Armstrong Donna J Inhibitors of AKT Activity
EA201290774A1 (ru) * 2010-02-11 2013-03-29 Вандербилт Юниверсити Пиразолопиридиновые, пиразолопиразиновые, пиразолопиримидиновые, пиразолотиофеновые и пиразолотиазоловые соединения как аллостерические потенциаторы mglur4, композиции и способы лечения неврологических дисфункций
KR20130044381A (ko) * 2010-03-04 2013-05-02 머크 샤프 앤드 돔 코포레이션 카테콜 ｏ－메틸 트랜스퍼라제의 억제제 및 정신병적 장애의 치료에서의 그의 용도
ES2677356T3 (es) * 2010-03-24 2018-08-01 Amitech Therapeutics Solutions, Inc. Compuestos heterocíclicos útiles para la inhibición de quinasas
CN102558147B (zh) * 2010-12-23 2014-09-17 江苏先声药物研究有限公司 化合物、制备方法及应用
US8802673B2 (en) 2011-03-24 2014-08-12 Hoffmann-La Roche Inc Heterocyclic amine derivatives
US9556135B2 (en) * 2012-10-12 2017-01-31 Amgen, Inc. Amino-dihydrothiazine and amino-dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use
US20150291625A1 (en) 2012-11-08 2015-10-15 Pfizer Inc. Heteroaromatic Compounds and their Use as Dopamine D1 Ligands
AU2013343105B2 (en) 2012-11-08 2016-04-14 Pfizer Inc. Heteroaromatic compounds as dopamine D1 ligands
CN102964340B (zh) * 2012-12-12 2015-10-07 中国药科大学 一类治疗阿尔茨海默病的选择性多巴胺d1受体激动剂
TR201907981T4 (tr) 2013-06-27 2019-06-21 Pfizer Heteroaromatik bileşikler ve bunların dopamin d1 ligandları olarak kullanımı.
EA201691831A1 (ru) 2014-04-25 2017-02-28 Пфайзер Инк. Гетероароматические соединения и их применение в качестве допаминовых d1 лигандов
US9868744B2 (en) 2014-04-25 2018-01-16 Pfizer Inc. Heteroaromatic compounds and their use as dopamine D1 ligands
EP3137469B1 (en) 2014-04-28 2019-10-09 Pfizer Inc Heterocyclic compounds and their use as dopamine d1 ligands
US9856263B2 (en) 2014-04-28 2018-01-02 Pfizer Inc. Heteroaromatic compounds and their use as dopamine D1 ligands

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AU2015249497A1 (en) 2016-10-20
WO2015162516A1 (en) 2015-10-29
TWI561517B (en) 2016-12-11
US9850232B2 (en) 2017-12-26
CR20160494A (es) 2016-12-20
MD20160109A2 (ro) 2017-04-30
CU20160156A7 (es) 2017-02-02
BR112016023740A2 (pt) 2017-08-15
AP2016009512A0 (en) 2016-10-31
US20160200711A1 (en) 2016-07-14
CA2946475A1 (en) 2015-10-29
PE20170009A1 (es) 2017-03-17
US9540352B2 (en) 2017-01-10
SG11201608468TA (en) 2016-11-29
DOP2016000289A (es) 2017-02-15
TW201604188A (zh) 2016-02-01
JP2017513881A (ja) 2017-06-01
SV2016005305A (es) 2017-07-19
IL248132A0 (en) 2016-11-30
PH12016501993A1 (en) 2017-01-09
US20150307494A1 (en) 2015-10-29
KR20160142402A (ko) 2016-12-12
EP3134404A1 (en) 2017-03-01
MA39914A (fr) 2017-03-01
TN2016000447A1 (en) 2018-04-04
MX2016013969A (es) 2017-01-11
CN107074843A (zh) 2017-08-18
EA201691788A1 (ru) 2017-03-31
JP6239149B2 (ja) 2017-11-29

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