PE20200494A1 - Polinucleotidos de aadc para el tratamiento de la enfermedad de parkinson - Google Patents

Polinucleotidos de aadc para el tratamiento de la enfermedad de parkinson

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Publication number
PE20200494A1
PE20200494A1 PE2019002526A PE2019002526A PE20200494A1 PE 20200494 A1 PE20200494 A1 PE 20200494A1 PE 2019002526 A PE2019002526 A PE 2019002526A PE 2019002526 A PE2019002526 A PE 2019002526A PE 20200494 A1 PE20200494 A1 PE 20200494A1
Authority
PE
Peru
Prior art keywords
parkinson
disease
treatment
aadc polynucleotides
aadc
Prior art date
Application number
PE2019002526A
Other languages
English (en)
Inventor
Maria Scheel
Bernard Ravina
Original Assignee
Voyager Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Voyager Therapeutics Inc filed Critical Voyager Therapeutics Inc
Publication of PE20200494A1 publication Critical patent/PE20200494A1/es

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    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/864—Parvoviral vectors, e.g. parvovirus, densovirus
    • C12N15/8645—Adeno-associated virus
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    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01028—Aromatic-L-amino-acid decarboxylase (4.1.1.28), i.e. tryptophane-decarboxylase

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composiciones y metodos para la preparacion, la fabricacion y el uso terapeutico de polinucleotidos que codifican AADC para el tratamiento de la enfermedad de Parkinson
PE2019002526A 2017-06-15 2018-06-14 Polinucleotidos de aadc para el tratamiento de la enfermedad de parkinson PE20200494A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762520084P 2017-06-15 2017-06-15
US201762554155P 2017-09-05 2017-09-05
PCT/US2018/037437 WO2018232055A1 (en) 2017-06-15 2018-06-14 Aadc polynucleotides for the treatment of parkinson's disease

Publications (1)

Publication Number Publication Date
PE20200494A1 true PE20200494A1 (es) 2020-03-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019002526A PE20200494A1 (es) 2017-06-15 2018-06-14 Polinucleotidos de aadc para el tratamiento de la enfermedad de parkinson

Country Status (19)

Country Link
US (2) US20190060425A1 (es)
EP (1) EP3638315A4 (es)
JP (1) JP2020527333A (es)
KR (1) KR20200018455A (es)
CN (1) CN111107879A (es)
AU (2) AU2018284960B2 (es)
BR (1) BR112019025122A2 (es)
CA (1) CA3065471A1 (es)
CL (1) CL2019003636A1 (es)
CO (1) CO2019013707A2 (es)
IL (1) IL270821A (es)
JO (1) JOP20190269A1 (es)
MA (1) MA49402A (es)
MX (1) MX2019014974A (es)
PE (1) PE20200494A1 (es)
PH (1) PH12019502793A1 (es)
SG (1) SG11201912154XA (es)
TW (1) TW201919713A (es)
WO (1) WO2018232055A1 (es)

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