KR20150014505A - 아과 e 원숭이 아데노바이러스 a1302, a1320, a1331 및 a1337 및 이것들의 사용 - Google Patents

아과 e 원숭이 아데노바이러스 a1302, a1320, a1331 및 a1337 및 이것들의 사용 Download PDF

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KR20150014505A
KR20150014505A KR1020147035481A KR20147035481A KR20150014505A KR 20150014505 A KR20150014505 A KR 20150014505A KR 1020147035481 A KR1020147035481 A KR 1020147035481A KR 20147035481 A KR20147035481 A KR 20147035481A KR 20150014505 A KR20150014505 A KR 20150014505A
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수미트라 로이
제임스 엠. 윌슨
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더 트러스티스 오브 더 유니버시티 오브 펜실바니아
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Abstract

재조합 벡터는 조절 서열의 제어 하에 원숭이 아데노바이러스 A1302 (SAdV-A1302), SAdV-A1320, SAdV-A1331, 및/또는 SAdV-A1337 서열 및 이종 기원 유전자를 포함한다. 원숭이 아데노바이러스 SAdV-A1302, SAdV-A1320, SAdV-A1331, 및/또는 SAdV-A1337 유전자(들)을 발현하는 세포주가 또한 개시된다. 벡터 및 세포주의 사용 방법이 제공된다.

Description

아과 E 원숭이 아데노바이러스 A1302, A1320, A1331 및 A1337 및 이것들의 사용{SUBFAMILY E SIMIAN ADENOVIRUSES A1302, A1320, A1331 AND A1337 AND USES THEREOF}
전자 양식으로 제출된 재료의 참조에 의한 통합
본원에 첨부된 서열 목록 재료는 본원에서 참고로 포함된다. 이 파일은 "UPN_Y6334PCT_ST25.txt"로 표시되며, 2013년 5월 17일에 생성되었고, 3,085,687 바이트 (2.94 MB)이다.
본 발명의 배경
아데노바이러스는 게놈 크기가 약 36 킬로베이스 (kb)인 이중-가닥 DNA 바이러스이며, 이것은 다양한 표적 조직에서 매우 효과적인 유전자 전송을 달성하는 그것의 능력 및 큰 전이 유전자 수용력으로 인해 유전자 전송 적용에 널리 사용되었다. 통상적으로, 아데노바이러스의 E1 유전자는 결실되고 선택된 프로모터, 원하는 유전자의 cDNA 서열 및 폴리 A 신호로 구성된 전이 유전자 카세트로 대체되며, 복제 결함 재조합 바이러스를 발생시킨다.
아데노바이러스는 많은 다른 부단백질(minor protein), VI, VIII, IX, IIIa 및 IVa2와 함께, 세 개의 주요 단백질, 헥손 (II), 펜톤 염기 (III) 및 놉 섬유(knobbed fibre) (IV)로 구성된 20면체 캡시드(capsid)를 갖는 특유의 형태를 갖는다 [W.C. Russell, J. Gen Virol., 81:2573-3704 (Nov 2000)]. 바이러스 게놈은 말단 단백질에 의해 5' 말단에 공유 결합에 의해 부착된 선형, 이중-가닥 DNA이며, 이것들은 역위 말단 반복 부위 (inverted terminal repeat; ITR)를 갖는다. 바이러스 DNA는 매우 염기성인 단백질 VII 및 작은 펩티드 pX (이전에는 mu로 불림)와 친밀하게 결합된다. 또 다른 단백질, V는 DNA-단백질 복합체로 포장되고 단백질 VI를 통해 캡시드에 대한 구조적 결합을 제공한다. 바이러스는 또한 바이러스-암호화된 프로테아제를 함유하며, 이것은 성숙한 감염성 바이러스를 생산하기 위해 구조 단백질 중 일부를 가공하는데 필요하다.
매스트아데노바이러스(mastadenovirus) 과에 대한 분류 계획이 개발되었으며, 이것은 인간, 원숭이, 소, 말, 돼지, 양, 개 및 주머니쥐 아데노바이러스를 포함한다. 이 분류 계획은 과에서 아데노바이러스 서열의 적혈구 세포를 응집시키는 상이한 능력을 기반으로 하여 개발되었다. 결과는 현재 부분군 A, B, C, D, E 및 F로 불리는 6개의 부분군이었다. T. Shenk et al, Adenoviridae: The Viruses and their Replication", Ch. 67, in FIELD'S VIROLOGY, 6m Ed., edited by B.N Fields et al, (Lippincott Raven Publishers, Philadelphia, 1996), p. 111-2112를 참고하면 된다.
재조합 아데노바이러스는 이종 기원 분자의 숙주 세포로의 전달에 대하여 설명되었다. 두 개의 침팬지 아데노바이러스. 원숭이 아데노바이러스, C5, C6 및 C7의 게놈을 설명하는 미국 특허 제6,083,716호는 미국 특허 번호 제7,247,472호에서 백신 벡터로서 유용한 것으로 설명되었다. 다른 침팬지 아데노바이러스는 제WO 2005/1071093호에서 아데노바이러스 백신 담체를 만드는데 유용한 것으로 설명된다.
업계에서 필요한 것은 분자를 표적에 효과적에 전달하고 집단에서 선택된 아데노바이러스 혈청형에 대한 기존 면역력의 효과를 최소화하는 벡터이다.
6개의 새로운 아과 E 원숭이 아데노바이러스의 분리된 핵산 서열 및 아미노산 서열, 및 이 서열들을 함유하는 벡터가 본원에서 제공된다. 또한 본 발명의 벡터 및 세포를 사용하는 많은 방법이 제공된다. 이 아데노바이러스들은 SAdV-A1302, SAdV-A1320, SAdV-A1331, 및 SAdV-A1337을 포함한다.
본원에서 설명된 방법은 본 발명의 벡터를 투여함으로써 하나 이상의 선택된 이종 기원 유전자(들)을 포유동물 환자에 전달하는 단계를 수반한다. 또한 분자를 표적 세포에 전달하는 단계에서 사용되는, 본원에서 설명된 아데노바이러스 또는 재조합 아데노바이러스가 제공된다. 분자를 표적 세포에 전달하는데 유용한 의약품의 제조에 있어서 본원에서 설명된 아데노바이러스 또는 재조합 아데노바이러스의 사용이 더 제공된다. 백신 접종을 위해 본원에서 설명된 조성물의 사용은 보호 면역 반응의 유도를 위해 선택된 항원의 제공을 허용한다. 이 원숭이 아데노바이러스 기반 벡터는 또한 시험관 내에서 이종 기원 유전자 생성물을 생산하는데 사용될 수도 있다. 이러한 유전자 생성물은 그 자체로 본원에서 설명된 바와 같은 다양한 목적을 위해 유용하다.
본 발명의 이 구체예 및 다른 구체예 및 이점들은 하기 더 상세히 설명된다.
도 1은 HIVgag(short)에 대한 전이 유전자를 가지고 있는 표시된 아데노바이러스 벡터의 주사 후 제8 일 및 제14 일에 HIVgag(short)에 대한 T 세포 반응을 반영하는 막대 그래프이다. T 세포 반응은 면역 우성 HIVgag short CD8 T 세포 에피토프 AMQMLKETI (SEQ ID NO: 410)를 사용하는 IFN-γ ELISPOT에 의해 분석되었다.
원숭이 아데노바이러스 SAdV-A1302, SAdV-A1320, SAdV-A1331, 및 SAdV-A1337 의 새로운 핵산 및 아미노산 서열이 제공되며, 이것들 모두는 침팬지 배설물에서 분리되었다.
또한 새로운 아데노바이러스 벡터 및 재조합 단백질 또는 단편의 시험관 내 생산에 사용되는 이 서열들 기반의 벡터를 생산하기 위한 포장 세포주 또는 다른 시약이 제공된다. 치료의 목적 또는 백신 목적을 위해 이종 기원 분자를 전달하는데 사용되는 조성물이 더 제공된다. 이러한 치료적 또는 백신 조성물은 삽입된 이종 기원 분자를 가지고 있는 아데노바이러스 벡터를 함유한다. 게다가, 새로운 SAdV 서열들은 재조합 아데노-연관 바이러스 (adeno-associated virus; AAV) 벡터의 생산에 필요한 필수 도우미 기능을 제공하는데 유용하다. 따라서, 이러한 생산 방법에 있어서 이 서열들을 사용하는 도우미 구조, 방법 및 세포주가 제공된다.
핵산 또는 이것의 단편을 언급할 때, 용어 "실질적 상동성" 또는 "실질적 유사성"은, 적절한 뉴클레오티드 삽입 또는 또 다른 핵산 (또는 그것의 상보성 가닥)의 결실로 최적으로 정렬될 때, 정렬된 서열의 적어도 약 95 내지 99%, 예를 들어, 약 96%, 약 97%, 약 98%, 및 약 99%의 뉴클레오티드 서열 동일성이 있다.
아미노산 또는 이것의 단편을 언급할 때, 용어 "실질적 상동성" 또는 "실질적 유사성"은, 적절한 아미노산 삽입 또는 또 다른 아미노산 (또는 그것의 상보성 가닥)의 결실로 최적으로 정렬될 때, 정렬된 서열의 적어도 약 95 내지 99%, 예를 들어, 약 96%, 약 97%, 약 98%, 및 약 99%의 아미노산 서열 동일성이 있다. 바람직하게, 상동성은 전장(full-length) 서열, 또는 이것의 단백질, 또는 길이가 적어도 8개의 아미노산, 또는 더 바람직하게는, 적어도 15개의 아미노산인 이것의 단편에 걸쳐 있다. 적합한 단편의 예는 본원에서 설명된다.
핵산 서열의 맥락에서 용어 "퍼센트 서열 동일성" 또는 "동일한"은 최대 일치를 위해 정렬될 때 같은 것인 두 개의 서열의 잔기를 나타낸다. 갭(gap)이 하나의 서열을 또 다른 것에 맞춰 정렬하는데 필요한 경우, 득점의 정도는 갭에 대한 패널티(penalty) 없이 더 긴 서열에 관하여 계산된다. 암호화된 폴리뉴클레오티드 또는 폴리펩티드의 기능성을 보존하는 서열은 이로 인해 더 밀접하게 동일하다. 서열 동일성 비교의 길이는 게놈의 전장 (예를 들어, 약 36 kbp)에 걸쳐 있을 수도 있고, 유전자, 단백질, 서브유닛, 또는 효소의 오픈 리딩 프레임(open reading frame)의 전장 [예를 들어, 아데노바이러스 암호화 영역을 제공하는 표를 참고하면 된다], 또는 적어도 약 500개 내지 5000개 뉴클레오티드의 단편이 필요하다. 하지만, 예를 들어, 적어도 약 9개의 뉴클레오티드, 보통 적어도 약 20개 내지 24개 뉴클레오티드, 적어도 약 28개 내지 32개의 뉴클레오티드, 적어도 약 36개 이상의 뉴클레오티드의 더 작은 단편 사이의 동일성이 또한 필요할 수도 있다. 유사하게, "퍼센트 서열 동일성"은, 단백질의 전당, 또는 이것의 단편에 걸쳐, 아미노산 서열에 대하여 쉽게 결정될 수도 있다. 적합하게, 단편은 길이가 적어도 약 8개의 아미노산이고, 약 700개 까지의 아미노산일 수도 있다. 적합한 단편의 예는 본원에서 설명된다.
동일성은 본원에서 초기 설정에서 정의된 이러한 알고리즘 및 컴퓨터 프로그램을 사용하여 쉽게 결정된다. 바람직하게, 이러한 동일성은 단백질, 효소, 서브유닛의 전장, 또는 길이가 적어도 약 8개의 아미노산인 단편에 걸쳐있다. 하지만, 동일성은, 동일한 유전자 생성물이 들어가는 사용에 맞춰진 경우에, 더 짧은 영역에 기초할 수도 있다.
본원에서 설명된 바와 같이, 정렬은 인터넷 상의 웹 서버(Web Server)를 통해 접근 가능한, "Clustal W"와 같이, 다양한 공개적으로 또는 상업적으로 이용 가능한 다중 서열 정렬 프로그램(Multiple Sequence Alignment Program)을 사용하여 수행된다 [Thompson et al, 1994, Nucleic Acids Res, 22, 4673-4680]. 대안으로, 벡터 NTI® 유틸리티 [InVitrogen]도 사용된다. 또한 뉴클레오티드 서열 동일성을 측정하기 위해 사용될 수 있는, 업계에 알려져 있는 많은 알고리즘이 있으며, 상기 설명된 프로그램에서 함유된 것들을 포함한다. 또 다른 예로서, 폴리뉴클레오티드 서열은 Fasta, GCG 버젼 6.1의 프로그램을 사용하여 비교될 수 있다. Fasta는 의문 서열 및 검색 서열 사이에서 최고로 중첩된 영역의 정렬 및 퍼센트 서열 동일성을 제공한다. 예를 들어, 핵산 서열 사이의 퍼센트 서열 동일성은 GCG 버젼 6.1에서 제공된 바와 같은 초기 파라미터(6의 글자 크기 및 득점 매트릭스에 대한 NOPAM 인자)를 갖는 Fasta를 사용하여 결정될 수 있으며, 본원에서 참고로 포함된다. 유사하게 프로그램들은 아미노산 성렬의 수행에 이용 가능하다. 일반적으로, 이 프로그램들은 초기 설정으로 사용되지만, 당업자는 필요에 따라 이 설정을 바꿀 수 있다. 대안으로, 당업자는 적어도 참조된 알고리즘 및 프로그램에 의해 제공된 것들과 같은 동일성의 수준 또는 정렬을 제공하는 또 다른 알고리즘 또는 컴퓨터 프로그램을 이용할 수 있다.
폴리뉴클레오티드에 적용된 바와 같이, "재조합"은 폴리뉴클레오티드가 다양한 조합의 클로닝, 제한 또는 결찰 단계, 및 자연에서 발견된 폴리뉴클레오티드와 별개의 구조를 발생시키는 다른 과정의 생성물이라는 것을 의미한다. 재조합 바이러스는 재조합 폴리뉴클레오티드를 포함하는 바이러스 입자이다. 용어는 각각 원래의 폴리뉴클레오티드 구조의 복제물 및 원래의 바리어릇 구조의 자손을 포함한다.
전형적으로, "이종 기원"은 비교되는 실체물의 나머지 것과 유전자형적으로 별개인 실체물로부터 유래되는 것을 의미한다. 이종 기원 핵산 서열은 아데노바이러스 벡터의 자연 발생 핵산 서열로부터 분리되지 않거나, 이것으로부터 유래되지 않거나, 이것을 기반으로 하지 않는 어떤 핵산 서열도 나타낸다. "자연 발생"은 자연에서 발견되고 합성에 의해 제조되거나 변형되지 않는 서열을 의미한다. 서열은 공급원으로부터 분리되지만 공급원 유전자의 정상 기능을 방해하지 않기 위해 변형될 때 (예를 들어, 결실, 치환 (돌연변이), 삽입, 또는 다른 변형에 의해) 공급원으로부터 "유래된다". 서열은 공급원과 실질적으로 유사할 때 공급원을 "기반으로 한다".
예를 들어, 유전적 조작 기술에 의해 다른 종 (및 종종 다른 속, 아과 또는 과)으로부터 유래된 플라스미드 또는 벡터로 도입된 폴리뉴클레오티드는 이종 기원 폴리뉴클레오티드이다. 자연의 암호화 서열로부터 제거되고 자연에서 결합된 것으로 발견되지 않는 암호화 서열에 작동 가능하게 결합된 프로모터는 이종 기원 프로모터이다. 바이러스의 게놈이 자연에서 함유하지 않는, 바이러스의 게놈 또는 바이러스 벡터로 클로닝된 특이적 재조합 부위는 이종 기원 재조합 부위이다. 이종 기원 핵산 서열은 또한 아데노바이러스 게놈에서 자연 발견되지만, 아데노바이러스 벡터 내 비-고유 위치에 위치하는 서열을 포함한다. 리콤비나제에 대한 암호화 서열을 갖는 폴리뉴클레오티드가 리콤비나제를 정상적으로 발현하지 않는 세포를 유전적으로 변화시키는데 사용될 때, 폴리뉴클레오티드 및 리콤비나제 둘 다는 세포에 대하여 이종 기원이다.
이종 기원 백신은 또 다른 종의 병원성 바이러스에 대한 면역력을 유발하기 위해 하나의 바이러스 또는 바이러스 벡터가 도입되는 경우를 나타낸다. 이 경우에서, 용어 "이종 기원"은 다른 종, 속, 아과, 또는 과 특이성을 갖는 바이러스로부터 유래된 접종 항원 및 도전 항원을 나타낸다.
본 명세서 및 청구범위를 통해 사용된 바와 같이, 용어 "포함하다" 및 다른 변종 중에서, "포함하다", "포함하는"을 포함하는 그것의 변형은 다른 성분, 요소, 정수, 단계 등을 포함한다. 용어 "구성되다" 또는 "구성되는"은 다른 성분, 요소, 정수, 단계 등을 제외한다.
I. 원숭이 아데노바이러스 서열
본 발명은 원숭이 아데노바이러스 SAdV-A1302, SAdV-A1320, SAdV-A1331, 및 SAdV-A1337 의 핵산 서열 및 아미노산 서열을 제공하며, 이것들은 각각 자연에서 결합되는 다른 재료로부터 분리된다.
A. 핵산 서열
본원에서 제공된 SAdV-A1302 핵산 서열은 SEQ ID NO: 1의 뉴클레오티드 1 내지 36430을 포함한다. SAdV-A1320 핵산 서열은 본원에서 SEQ ID NO: 25의 뉴클레오티드 1 내지 36603을 포함한다. 본원에서 제공된 SAdV-A1331 핵산 서열은 SEQ ID NO: 50의 뉴클레오티드 1 내지 36647을 포함한다. 본원에서 제공된 SAdV-A1337 핵산 서열은 SEQ ID NO: 77의 뉴클레오티드 1 내지 36639를 포함한다. 서열 목록을 참고하면 되며, 이것은 본원에서 참고로 포함된다.
한 구체예에서, 본 발명의 핵산 서열은 각각 SEQ ID NO: 1, 25, 50, 또는 77의 서열에 상보성인 가닥, 뿐만 아니라 서열에 해당하는 RNA 및 cDNA 서열 및 그것들의 상보성 가닥을 더 포함한다. 또 다른 구체예에서, 핵산 서열은 서열 목록과 98.5% 이상 동일하고, 바람직하게는 99% 이상 동일한 서열을 더 포함한다. 또한 한 구체예에서, SEQ ID NO: 1, 25, 50, 또는 77 및 그것들의 상보성 가닥에서 제공된 서열의 자연적 변종 및 조작된 변형이 포함된다. 이러한 변형은, 예를 들어, 업계에 알려져 있는 표지(label), 메틸화, 및 자연 발생 뉴클레오티드 중 하나 이상의 퇴화 뉴클레오티드로의 치환을 포함한다.
핵산 영역

표 1 - 핵산 영역



영역


SAdV-A1302
ORF
SEQ ID
NO: 1

SAdV-1320
ORF
SEQ ID
NO: 25
SAdV-A1331
ORF
SEQ ID
NO: 50
SAdV-A1337
ORF
SEQ ID
NO: 77
ITR 1.129 7.129
E1a 13S
12S
9S		 (576.1154,
1231.1434)		 (576.1151,
1236.1439)
E1b 작은 T/19K 1590.2168 1599.2174 1601.2173 1601.2164
큰 T/55K 1895.3409 1904.3415
 1906.3414
 1906.3405
E2b pTP 보체 (8560.10391,
13825.13833)		 보체
(8469.10406,
13856.13864)		 보체
(8465.10399,
13849.13857)		 보체
(8466.10394,
13836.13844)
폴리머라제 보체
(5593.8652,
13825.13833) 		보체
(5599.8661,
13856.13864)
 보체
(5091.8657,
13849.13857)
 보체
(5593.8658,
13836.13844)
IVa2 보체
(3983.5313,
5593.5604)		 보체
(3989.5319,
5599.5610)		 보체
(3988.5318,
5598.5609)		 보체
(3983.5313,
5593.5604)
L1 52/55D 10828.12006 10862.12034 10855.12030 10831.12012
IIIa 12033.13790 12061.13821 12057.13814 12039.13805
L2 펜톤 13873.15456 13904.15529 13897.15513 13889.15484
VII 15463.16067 15535.16117
 15520.16101
 15491.16069
V 16092.17123
 16165.17208 16149.17186 16114.17139
pX 17149.17397 17236.17466 17214.17444 17166.17396
L3 VI 17451.18173 17539.18270 17517.18233 17431.18207
헥손 18217.21066 18377.21205 18337.21168 18313.21105
엔도프로테아제
 21085.21711 21227.21850 21190.21813 21121.21750
E2a DBP
보체
(21796.23328)
 보체
(21935.23470)
 보체
(21894.23429)
 보체
(21830.23365)
L4 100kD 23354.25744 23499.25892 23458.25866 23394.25796
22 kD
 25470.26021 25615.26169 25586.26131 25519.26070
VIII 26367.27047 26518.27198 26474.27154 26418.27098
E3
12.5K 27051.27368 27202.27519 27158.27475 27102.27419
CR1-알파 27325.27945 27476.28096 27432.28055 27376.28011
gp19K 27930.28457 28081.28608 28040.28567 27996.28523
CR1-베타 28490.29083 28641.29240 28604.29287 28562.29302
CR1-감마 29099.29707 29257.29868 29303.29911 29318.29941
CR1-델타 29725.30597 29886.30761 29929.30792 29964.30836
RID-베타 30889.31317 31053.31481 31084.31515 31123.31569
14.7K 31313.31717 31477.31881 31511.31915 31565.31966
L5 섬유질 32014.33333 32178.33512 32212.33546 32078.33547
E4

Orf 6/7		 보체
(33431.33681,
34414.34764)
 보체
(33605. 33855,
34588.34938)
 보체
(33644.33894,
34627.34797)
 보체
(33643.33893, 34617.34970)
Orf 6 보체
(33682.34584)
 보체
(33856.34758)
 보체
(33895.34797)
 보체
(33894.34790)
Orf 4 보체
(34493.34855)		 보체
(34667.35029)
 보체
(34706.35068)
 보체
(34696.35061)
Orf 3 보체
(34868.35218)		 보체
(35081.35431)
 보체
(35073.35423)
Orf 2 보체
(35218.35604)		 보체
(35431.35817)		 보체
(35423.35809)
Orf1
 보체
(35870.36241)		 보체 (35862.36233)
ITR 보체
(36519.36647)
 보체
(36511.36633)
한 구체예에서, SEQ ID NO: 1, 25, 50, 또는 77의 서열 및 그것들의 상보성 가닥, 그것과 상보적인 cDNA 및 RNA의 단편이, 그것들에 대하여 실질적 상동성을 갖는 단편과 함께, 제공된다. 적합한 단편은 길이가 적어도 15개의 뉴클레오티드이며, 기능적 단편, 즉, 생물학적으로 원하는 단편을 포함한다. 예를 들어, 기능적 단편은 바람직한 아데노바이러스 생성물을 발현할 수 있거나 재조합 바이러스 벡터의 생산에 유용할 수도 있다. 이러한 단편은 본원에서 표에서 나열된 유전자 서열 및 단편을 포함한다. 표는 SAdV-A1302, SAdV-A1320, SAdV-A1331, 및 SAdV-A1337 서열의 전사 영역 및 오픈 리딩 프레임을 제공한다. 특정 유전자에 대하여, 전사 및 오픈 리딩 프레임 (ORF)은 SEQ ID NO: 1, 25, 50, 또는 77에서 제공되는 것들과 상보적인 가닥에 위치한다. 예를 들어, E2a, E2b, 및 E4를 참고하면 된다. 암호화된 단백질의 계산된 분자량이 또한 나타난다. E1a 오픈 리딩 프레임, E2b 오픈 리딩 프레임, 및 E4 오픈 리딩 프레임이 내부 스플라이스(splice) 부위를 함유한다는 것을 주목해야 한다. 이 스플라이스 부위들은 상기 표에서 나타나 있다.
SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 아데노바이러스 핵산 서열은 치료제로서 및 다양한 벡터 시스템 및 숙주 세포의 구조에서 유용하다. 본원에서 사용된 바와 같이, 벡터는 네이키드(naked) DNA, 플라스미드, 바이러스, 코스미드, 또는 에피솜을 포함하는 어떤 적합한 핵산 분자도 포함한다. 이 서열들 및 생성물들은 단독으로 또는 다른 아데노바이러스 서열 또는 단편과 조합하여, 또는 다른 아데노바이러스 또는 비-아데노바이러스 서열의 요소와 조합하여 사용될 수도 있다. SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 서열은 또한 안티센스(antisense) 전달 벡터, 유전자 치료 벡터, 또는 백신 벡터로서 유용하다. 따라서, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 서열을 함유하는 핵산 분자, 유전자 전달 벡터, 및 숙주 세포가 더 제공된다.
예를 들어, 본 발명은 본 발명의 원숭이 Ad ITR 서열을 함유하는 비-자연 발생 핵산 분자를 포함한다. "비-자연 발생"은 자연에서 발견될 수 없는 서열 또는 유전적 요소를 나타내고, 벡터의 자손 및 같은 것을 함유하는 숙주 세포와 함께, 재조합, 유전적 조작, 또는 다른 기술을 통해 합성되거나, 재배열되거나, 또는 변형되었다. 또 다른 예에서, 본 발명은 원하는 Ad 유전자 생성물을 암호화하는, 본 발명의 원숭이 Ad 서열을 함유하는 핵산 분자를 제공한다. 본 발명의 서열을 사용하여 구성된 또 다른 핵산 분자는, 본원에서 제공된 정보를 고려하여, 당업자에게 쉽게 분명해질 것이다.
한 구체예에서, 본원에서 확인된 원숭이 Ad 유전자 영역은 이종 기원 분자의 세포로의 전달을 위해 다양한 벡터에서 사용될 수도 있다. 예를 들어, 벡터는 포장 숙주 세포에서 바이러스 벡터를 생성할 목적을 위해 아데노바이러스 캡시드 단백질 (또는 이것의 단편)의 발현을 위해 생성된다. 이러한 벡터는 인 트랜스(in trans) 발현을 목적으로 설계될 수도 있다. 대안으로, 이러한 벡터는 원하는 아데노바이러스 기능을 발현하는 서열, 예를 들어, E1a, E1b, 말단 반복 서열, E2a, E2b, E4, E40RF6 영역 중 하나 이상을 안정하게 함유하는 세포를 제공하도록 설계된다.
게다가, 아데노바이러스 유전자 서열 및 이것들의 단편은 도우미-의존 바이러스 (예를 들어, 필수 기능이 결실된 아데노바이러스 벡터, 또는 아데노-연관 바이러스 (AAV))의 생산에 필요한 도우미 기능의 제공에 유용하다. 이러한 생산 방법을 위해, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 서열은 사람 Ad에 대하여 설명된 것들과 유사한 방식으로 이러한 방법에서 이용될 수 있다. 하지만, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 서열 및 사람 Ad의 그것 사이에서 서열의 차이로 인해, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 서열의 사용은 인간 Ad E1 기능을 갖고 있는 숙주 세포, 예를 들어, 293 세포에서 도우미 기능과의 상동 재조합의 가능성을 크게 축소하거나 제거하며, 이것들은 rAAV 생산 중에 감염성 아데노바이러스 오염 물질을 생산할 수도 있다.
아데노바이러스 도우미 기능을 사용하여 rAAV를 생산하는 방법은 인간 아데노바이러스 혈청형에 관한 문헌에서 상세히 설명되었다. 예를 들어, 미국 특허 제6,258,595호 및 그 안에서 인용된 참고문헌을 참고하면 된다. 또한 미국 특허 제5,871,982호; 제WO 99/14354호; 제WO 99/15685호; 제WO 99/47691호를 참고하면 된다. 이 방법들은 또한 비-인간 영장류 AAV 혈청형을 포함하는, 비-인간 혈청형 AAV의 생산에 있어서 사용될 수도 있다. 필수 도우미 기능을 제공하는 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 서열 (예를 들어, E1a, E1b, E2a, E2b, DNA 폴리머라제 및/또는 E4 ORF6)은 필수 아데노바이러스 기능을 제공하는데 특히 유용할 수 있는 한편 전형적으로 인간 기원인 rAAV-포장 세포에 존재하는 어떤 다른 아데노바이러스와의 재조합 가능성을 축소하거나 제거한다. 따라서, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 서열의 선택된 유전자 또는 오픈 리딩 프레임은 이 rAAV 생산 방법에서 이용될 수도 있다.
대안으로, 재조합 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 벡터가 이 방법에서 이용될 수도 있다. 이러한 재조합 아데노바이러스 원숭이 벡터는, 예를 들어, 발현을 제어하는 조절 서열의 제어 하에서 침팬지 Ad 서열이, 예를 들어, AAV 3' 및/또는 5' ITR 및 전이 유전자로 구성된 rAAV 발현 카세트를 플랭킹하는(flank) 하이브리드(hybrid) 침팬지 Ad/AAV를 포함할 수도 있다. 당업자는 또 다른 원숭이 아데노바이러스 벡터 및/또는 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 유전자 서열이 아데노바이러스 도우미에 의존적인 rAAV 및 다른 바이러스의 생산에 유용하다는 것을 인식할 것이다.
또 다른 구체예에서, 핵산 분자는 원하는 생리학적 효과를 달성하기 위해 숙주 세포에서 선택된 아데노바이러스 유전자 생성물의 전달 및 발현을 목적으로 설계된다. 예를 들어, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 E1a 단백질을 암호화하는 서열을 함유하는 핵산 분자는 암 치료제로서 사용을 위해 대상에 전달될 수도 있다. 선택적으로, 이러한 분자는 지질-기반 담체 및 바람직하게는 표적 암 세포에서 제형화된다. 이러한 제형은 다른 암 치료제 (예를 들어, 시스플라틴, 탁솔, 등)와 조합될 수도 있다. 본원에서 제공된 아데노바이러스 서열에 대한 또 다른 사용은 당업자에게 쉽게 분명해질 것이다.
게다가, 당업자는 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 서열이 치료제 및 면역원성 분자의 시험관 내, 생체 외 또는 생체 내 전달을 위해 다양한 바이러스 및 비-바이러스 벡터 시스템에 대한 사용에 쉽게 적용될 수 있다는 것을 쉽게 이해할 것이다. 예를 들어, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 원숭이 Ad 서열은 다양한 rAd 및 비-rAd 벡터 시스템에서 이용될 수 있다. 이러한 벡터 시스템은 다른 것들 중에서, 예를 들어, 플라스미드, 렌티바이러스(lentivirus), 레트로바이러스(retrovirus), 폭스바이러스(poxvirus), 우두 바이러스(vaccinia virus), 및 아데노-연관 바이러스 시스템을 포함할 수도 있다. 이 벡터 시스템들의 선택은 본 발명의 제한이 아니다.
본 발명은 원숭이의 생산에 유용한 분자 및 본 발명의 원숭이-유래된 단백질을 더 제공한다. 본 발명의 원숭이 Ad DNA 서열을 포함하는 폴리뉴클레오티드를 가지고 있는 이러한 분자들은 네이키드 DNA, 플라스미드, 바이러스 또는 어떤 다른 유전적 요소의 형태일 수 있다.
B. SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 아데노바이러스 단백질
SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 아데노바이러스의 유전자 생성물, 예를 들어, 단백질, 효소, 및 이것들의 단편이 제공되며, 본원에서 설명된 아데노바이러스 핵산에 의해 암호화된다. SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 단백질, 효소, 및 이것들의 단편이 더 포함되며, 다른 방법에 의해 생성되는 이 핵산 서열들에 의해 암호화된 아미노산 서열을 갖는다. 이러한 단백질은 상기 표에서 확인된 오픈 리딩 프레임에 의해 암호화된 것들, SEQ ID NO를 참고로 하여 하기 표에서 확인된 단백질들을 포함하며, 이것들은 서열 목록에서 제공되고 서열들은 그것들에 대하여 실질적 상동성을 갖는다.
Figure pct00001
*NC = 서열 목록 내에서 암호화 가능하지 않은 영역
따라서, 한 양태에서, 실질적으로 순수한, 즉, 다른 바이러스성 단백질 및 단백질성 단백질로부터 떨어진 독특한 원숭이 아데노바이러스 단백질이 제공된다. 바람직하게, 이 단백질들은 적어도 10% 균질하고, 더 바람직하게는 60% 균질하고, 가장 바람직하게는 95% 균질하다.
한 구체예에서, 독특한 원숭이-유래된 캡시드 단백질이 제공된다. 본원에서 사용된 바와 같이, 원숭이-유래된 캡시드 단백질은 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 캡시드 단백질 또는 이것들의 단편을 함유하는 어떤 아데노바이러스 캡시드 단백질도 포함하며, 상기 정의된 바와 같이, 제한 없이, 키메라 캡시드 단백질, 융합 단백질, 인공적 캡시드 단백질, 합성 캡시드 단백질, 및 재조합 캡시드 단백질을 포함하고, 이 단백질들을 생성하는 수단에 제한되지 않는다. 본원에서 설명된 캡시드는 완전히 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 중 하나가 될 수도 있거나, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 중 하나 이상의 캡시드 단백질을 함유할 수도 있거나, 또는 또 다른 아데노바이러스의 캡시드 단백질을 함유할 수도 있다.
적합하게, 이 원숭이-유래된 캡시드 단백질은 다른 아데노바이러스 혈청형의 캡시드 영역 또는 이것들의 단편, 또는 변형된 원숭이 캡시드 단백질 또는 단편과 조합하여 하나 이상의 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 영역 또는 이것들의 단편 (예를 들어, 헥손, 펜톤, 섬유, 또는 이것들의 단편)을 함유하며, 본원에서 설명된 바와 같다. 본원에서 사용된 바와 같이 "변화된 향성(tropism)과 관련된 캡시드 단백질의 변형"은, 특이성이 변화되도록, 변화된 캡시드 단백질, 즉, 펜톤, 헥손 또는 섬유 단백질 영역, 또는 이것들의 단편, 예를 들어, 섬유 영역의 놉 도메인(knob domain), 또는 같은 것을 암호화하는 폴리뉴클레오티드를 포함한다. 원숭이-유래된 캡시드는 본 발명의 원숭이 Ad 또는 인간 또는 비-인간 기원일 수도 있는 또 다른 Ad 혈청형 중 하나 이상으로 구성될 수도 있다. 이러한 Ad는 ATCC, 상업적 및 학술적 공급원을 포함하는 다양한 공급원으로부터 얻을 수도 있거나, 또는 Ad의 서열은 GenBank 또는 다른 적합한 공급원으로부터 얻을 수도 있다.
SAdV-A1302 [SEQ ID NO: 5], SAdV-A1320 [SEQ ID NO: 29], SAdV-A1331 [SEQ ID NO: 54], 또는 SAdV-A1337 [SEQ ID NO: 81]의 펜톤 단백질의 아미노산 서열이 제공된다. 적합하게, 이 펜톤 단백질, 또는 이것들의 독특한 단편들은 다양한 목적을 위해 이용될 수도 있다. 적합한 단편의 예는 상기 제공된 및 SEQ ID NO: 5, 29, 54, 또는 81의 아미노산 넘버링(numbering)에 기초하여, 약 50개, 100개, 150개, 또는 200개 아미노산의 N-말단 및/또는 C-말단 절단을 갖는 펜톤을 포함한다. 다른 적합한 단편은 더 짧은 내부, C-말단, 또는 N-말단 단편을 포함한다. 게다가, 펜톤 단백질은 당업자들에게 알려져 있는 다양한 목적을 위해 변형될 수도 있다.
또한, SAdV-A1302 [SEQ ID NO: 9], SAdV-A1320 [SEQ ID NO: 34], SAdV-A1331 [SEQ ID NO: 59], 또는 SAdV-A1337 [SEQ ID NO: 86]의 헥손 단백질의 아미노산이 제공된다. 적합하게, 이 헥손 단백질, 또는 이것들의 독특한 단편들은 다양한 목적을 위해 이용될 수도 있다. 적합한 단편의 예는 상기 제공된 및 SEQ ID NO: 9, 34, 59, 또는 86의 아미노산 넘버링에 기초하여, 약 50개, 100개, 150개, 200개, 300개, 400개, 또는 500개 아미노산의 N-말단 및/또는 C-말단 절단을 갖는 헥손을 포함한다. 다른 적합한 단편은 더 짧은 내부, C-말단, 또는 N-말단 단편을 포함한다. 예를 들어, 하나의 적합한 단편, 헥손 단백질의 루프(loop) 영역(도메인)은 DE1 및 FG1, 또는 이것들의 초가변 영역으로 지정되었다. 이러한 단편은, SEQ ID NO: 9, 34, 59, 또는 86을 참고하여, 아미노산 잔기 약 125 내지 443; 약 138 내지 441, 또는 더 작은 단편을 스패닝(spanning)하는 영역, 예를 들어, 원숭이 헥손 단백질의 약 잔기 138 내지 잔기 163; 약 170 내지 약 176; 약 195 내지 약 203; 약 233 내지 약 246; 약 253 내지 약 374; 약 287 내지 약 297; 및 약 404 내지 약 430을 스패닝하는 것들을 포함한다. 다른 적합한 단편은 당업자에 의해 쉽게 확인될 수도 있다. 게다가, 헥손 단백질은 당업자들에게 알려져 있는 다양한 목적을 위해 변형될 수도 있다. 헥손 단백질이 아데노바이러스의 혈청형에 대한 결정요인이기 때문에, 이러한 인공적인 헥손 단백질은 인공적인 혈청형을 갖는 아데노바이러스를 발생시킬 것이다. 다른 인공적인 캡시드 단백질은 또한 본 발명의 침팬지 Ad 펜톤 서열 및/또는 섬유 서열 및/또는 이것들의 단편을 사용하여 구성될 수 있다.
한 구체예에서, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 헥손 단백질의 서열을 이용하는 변화된 헥손 단백질을 갖는 아데노바이러스가 생성될 수도 있다. 헥손 단백질을 변화시키는 하나의 적합한 방법은 미국 특허 제5,922,315호에서 설명되며, 이것은 참고로 포함된다. 이 방법에서, 아데노바이러스 헥손의 적어도 하나의 루프 영역은 또 다른 아데노바이러스 혈청형의 적어도 하나의 루프 영역과 바꾸어진다. 따라서, 이러한 변화된 아데노바이러스 헥손 단백질의 적어도 하나의 루프 영역은 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 의 원숭이 Ad 헥손 루프 영역이다. 한 구체예에서, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 헥손 단백질의 루프 영역은 또 다른 아데노바이러스 혈청형의 루프 영역에 의해 대체된다. 또 다른 구체예에서, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 헥손의 루프 영역은 또 다른 아데노바이러스 혈청형의 루프 영역을 대체하기 위해 사용된다. 본원에서 설명된 바와 같이, 적합한 아데노바이러스 혈청형은 인간 및 비-인간 혈청형 중에서 쉽게 선택될 수도 있다. 적합한 혈청형의 선택은 본 발명의 제한은 아니다. SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 헥손 단백질 서열에 대한 또 다른 사용은 당업자들에게 쉽게 분명해질 것이다.
SAdV-A1302 [SEQ ID NO: 19], SAdV-A1320 [SEQ ID NO: 44], SAdV-A1331 [SEQ ID NO: 69], 또는 SAdV-A1337 [SEQ ID NO: 96]의 섬유 단백질의 아미노산 서열이 제공된다. 적합하게, 이 섬유 단백질, 또는 이것들의 독특한 단편은 다양한 목적을 위해 이용될 수도 있다. 하나의 적합한 단편은 섬유 놉이며, SEQ ID NO: 19, 44, 69, 또는 96 내에 위치한다. 다른 적합한 단편의 예는, SEQ ID NO: SEQ ID NO: 19, 44, 69, 또는 96에서 제공된 아미노산 넘버링에 기초하여, 약 50개, 100개, 150개, 또는 200개 아미노산의 N-말단 및/또는 C-말단 절단을 갖는 섬유를 포함한다. 또 다른 적합한 단편은 내부 단편을 포함한다. 게다가, 섬유 단백질은 당업자들에게 알려져 있는 다양한 기술을 사용하여 변형될 수도 있다.
SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 의 단백질의 독특한 단편은 길이가 적어도 8개의 아미노산이다. 하지만, 다른 원하는 길이의 단편이 쉽게 이용될 수 있다. 게다가, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 유전자 생성물의 수득 및/또는 발현을 향상시키기 위해 도입될 수도 있는 변형, 예를 들어, 향상시키기 위해 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 유전자 생성물 모두 또는 단편이 융합 파트너와 융합되는 (직접적으로 또는 결합자를 통해) 융합 분자의 구성이 본원에서 제공된다. 다른 적합한 변형은, 제한 없이, 보통 분할된 프리-단백질(pre-protein) 또는 프로-단백질(pro-protein)을 제거하기 위해 및 성숙한 단백질 또는 효소를 제공하기 위해 암호화 영역 (예를 들어, 단백질 또는 효소)의 절단 및/또는 분비성 유전자 생성물을 제공하기 위한 암호화 영역의 돌연변이를 포함한다. 또 다른 변형은 당업자들에게 쉽게 분명해질 것이다. 본원에서 제공된 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 단백질에 대하여 적어도 약 98%, 약 99%, 약 99.5%, 또는 약 99.9 동일성을 갖는 단백질이 더 포함된다.
본원에서 설명된 바와 같이, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 의 아데노바이러스 캡시드 단백질을 함유하는 본 발명의 벡터는 중화 항체가 다른 Ad 혈청형 기반 벡터, 뿐만 아니라 다른 바이러스 벡터의 효과를 감소시키는 적용에서의 사용에 특히 적합하다. rAd 벡터는 반복 유전자 치료 또는 면역 반응 (백신 역가)의 촉진을 위한 재투여에 특히 유리하다.
특정한 경우에, 항체를 생성하기 위해 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 유전자 생성물 중 하나 이상 (예를 들어, 캡시드 단백질 또는 이것의 단편)을 사용하는 것이 바람직할 수도 있다. 본원에서 사용된 바와 같이, 용어 "항체"는 에피토프에 특이적으로 결합할 수 있는 면역글로불린 분자를 나타낸다. 항체는, 예를 들어, 고친화도 다클론성 항체, 단클론성 항체, 합성 항체, 키메라 항체, 재조합 항체 및 인간화된 항체를 포함하는 다양한 형태로 존재할 수도 있다. 이러한 항체는 면역글로불린 등급 IgG, IgM, IgA, IgD 및 IgE로부터 기원한다.
이러한 항체는 업계에 알려져 있는 많은 방법 중 어떤 것을 사용해서 생성될 수도 있다. 적합한 항체는 잘 알려진 통상적인 기술, 예를 들어, 쾰러 및 밀스테인 (Kohler and Milstein) 및 이것의 많은 알려진 변형들에 의해 생성될 수도 있다. 유사하게 바람직한 고역가 항체는 알려진 재조합 기술을 이 항원들에 대하여 개발된 단클론성 또는 다클론성 항체에 적용함으로써 생성되었다 [예를 들어, PCT 특허 출원 번호 제PCT/GB 85/00392호; 영국 특허 출원 공개 번호 제GB2188638A호; Amit et al., 1986 Science, 233:747-753; Queen et al, 1989 Proc. Nat'l. Acad. Sci. USA, 86:10029-10033; PCT 특허 출원 번호 제PCT/WO9007861호; 및 Riechmann et al., Nature, 332:323-327 (1988); Huse et al, 1988a Science, 246: 1275-1281을 참고하면 된다]. 대안으로, 항체는 본 발명의 항원에 대한 동물 또는 인간 항체의 상보성 결정 영역을 조작함으로써 생산될 수 있다. 예를 들어, E. Mark and Padlin, "Humanization of Monoclonal Antibodies", Chapter 4, The Handbook of Experimental Pharmacology, Vol. 113, The Pharmacology of Monoclonal Antibodies, Springer-Verlag (June, 1994); Harlow et al, 1999, Using Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory Press, NY; Harlow et al, 1989, Antibodies: A Laboratory Manual, Cold Spring Harbor, New York; Houston et al, 1988, Proc. Natl. Acad. Sci. USA 55:5879-5883; 및 Bird et al, 1988, Science 242:423-437을 참고하면 된다. 본 발명에 의해 항-이디오타입 항체 (Ab2) 및 항-항-이디오타입 항체 (Ab3)가 더 제공된다. 예를 들어, M. Wettendorff et al., "Modulation of Anti-tumor immunity by anti-idiotypic antibodies". In Idiotypic Network and Diseases, ed. by J. Cerny and J. Hiernaux, 1990 J. Am. Soc. Microbiol., Washington DC: pp. 203-229를 참고하면 된다. 이 항-이디오타입 및 항-항-이디오타입 항체는 당업자들에게 잘 알려져 있는 기술을 사용하여 생산된다. 이 항체들은 진단적 및 임상적 방법 및 키트를 포함하는, 다양한 목적을 위해 사용될 수도 있다.
특정한 경우에, 검출 가능한 표지 또는 태그(tag)를 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 유전자 생성물, 항체 또는 본 발명의 다른 구조로 도입하는 것이 바람직할 수도 있다. 본원에서 사용된 바와 같이, 검출 가능한 표지는, 단독으로 또는 또 다른 분자와 상호작용시, 검출 가능한 신호를 제공하는 것이 가능한 분자이다. 가장 바람직하게, 표지는 면역조직화학적 분석 또는 면역 형광 현미경 검사에서 사용할 준비를 위해, 예를 들어, 형광 발광에 의해, 시각적으로 검출 가능하다. 예를 들어, 적합한 표지는 플루오레세인 이소티오시아네이트 (FITC), 피코에리트린 (PE), 알로피코시아닌 (APC), 코리포스핀-0 (CPO) 또는 탠덤(tandem) 연료, PE-시아닌-5 (PC5), 및 PE-텍사스 레드(Texas Red) (ECD)를 포함한다. 이 형광 염료들 모두는 상업적으로 이용 가능하고, 그것들의 사용은 업계에 알려져 있다. 다른 유용한 표지는 콜로이드성 금 표지를 포함한다. 또 다른 유용한 표지는 방사성 화합물 또는 요소를 포함한다. 추가적으로, 표지는 검정에서 비색 신호를 나타내도록 작동하는, 예를 들어, 글루코스 옥시다제 (기질로서 글루코스를 사용함)가 퍼옥시다제 및 테트라메틸 벤지딘 (TMB)과 같은 수소 기증자의 존재시 파란 색으로 보이는 산화된 TMB를 생산하는 생성물로서 퍼옥시드를 방출하는 다양한 효소 시스템을 포함한다. 다른 예는, 다른 생성물 중에서, 340 nm 파장에서 증가된 흡광도로 검출되는 NADH를 수득하기 위해 ATP, 글루코스, 및 NAD+와 반응하는 글루코스-6-포스페이트 데히드로게나제와 함께 홀스래디쉬 퍼옥시다제 (HRP), 알칼린 포스파타제 (AP), ALC 헥소키나제를 포함한다.
본원에서 설명된 방법에서 이용되는 다른 표지 시스템은 다른 수단에 의해 검출 가능한데, 예를 들어, 염료가 임베딩된 (embedded)되는 착색 라텍스 미세입자 [Bangs Laboratories, Indiana]는 적용 가능한 검정에서 결과의 복합체의 존재를 나타내는 시작적 신호를 제공하도록 표적 서열과 컨쥬게이트(conjugate)를 형성하기 위해서 효소를 대신해서 사용된다.
표지를 원하는 분자와 커플링(coupling)하거나 결합시키는 방법은 유사하게 통상적이고 당업자들에게 알려져 있다. 표지 부착의 알려져 있는 방법이 설명된다 [예를 들어, Handbook of Fluorescent probes and Research Chemicals, 6th Ed., R. P. M. Haugland, Molecular Probes, Inc., Eugene, OR, 1996; Pierce Catalog and Handbook, Life Science and Analytical Research Products, Pierce Chemical Company, Rockford, IL, 1994/1995를 참고하면 된다]. 따라서, 표지 및 커플링 방법의 선택은 본 발명을 제한하지 않는다.
SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 의 서열, 단백질, 및 단편들은 재조합 생산, 화학적 합성, 또는 다른 합성 수단을 포함하는 어떤 적합한 수단에 의해서도 생산될 수 있다. 적합한 생산 기술은 당업자들에게 잘 알려져 있다. 예를 들어, Sambrook et al, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press (Cold Spring Harbor, NY)를 참고하면 된다. 대안으로, 펩티드는 또한 잘 알려진 고체상 펩티드 합성 방법에 의해 합성될 수 있다 (Merrifield, J. Am. Chem. Soc., 85:2149 (1962); Stewart and Young, Solid Phase Peptide Synthesis (Freeman, San Francisco, 1969) pp. 27-62). 여러 적합한 생산 방법은 당업자의 지식 내에 있고 본 발명을 제한하는 것은 아니다.
게다가, 당업자는 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 서열이 치료적 및 면역원성 분자의 시험관 내, 생체 외 또는 생체 내 전달을 위한 다양한 바이러스 및 비-바이러스 벡터 시스템에 사용에 쉽게 적용될 수 있다는 것을 쉽기 이해할 것이다. 예를 들어, 한 구체예에서, 원숭이 Ad 캡시드 단백질 및 본원에서 설명된 다른 원숭이 아데노바이러스 단백질은 유전자, 단백질 및 다른 바람직한 진단적, 치료적 및 면역원성 분자의 비-바이러스, 단백질-기반 전달에 사용된다. 이러한 하나의 구체예에서, 본 발명의 단백질은 아데노바이러스에 대한 수용체를 갖는 세포로 표적화하하는 분자에 직접적으로 또는 간접적으로 결합된다. 바람직하게는, 세포 표면 수용체에 대한 리간드를 갖는 헥손, 펜톤, 섬유 또는 이것들의 단편과 같은 캡시드 단백질이 이러한 표적화를 위해 선택된다. 전달에 적합한 분자는 본원에서 설명된 치료적 분자 및 그것들의 유전자 생성물 중에서 선택된다. 지질, 폴리Lys, 등을 포함하는 다양한 결합자가 결합자로서 이용될 수도 있다. 예를 들어, 원숭이 펜톤 단백질은 Medina-Kauwe LK, et al, Gene Ther. 2001 May; 8(10):795-803 and Medina-Kauwe LK, et al, Gene Ther. 2001 Dec; 8(23): 1753-1761에서 설명된 것들과 유사한 방식으로 원숭이 펜톤 서열을 사용하는 융합 단백질의 생산에 의해 이러한 목적으로 쉽게 이용될 수도 있다. 대안으로, 원숭이 Ad 단백질 IX의 아미노산 서열은, 미국 특허 출원 제20010047081호에서 설명된 바와 같이, 벡터를 세포 표면 수용체로 표적화하는데 이용될 수도 있다. 적합한 리간드는 CD40 항원, GD-함유 또는 폴리리신-함유 서열, 등을 포함한다. 예를 들어, 헥손 단백질 및/또는 섬유 단백질을 포함하는 또 다른 원숭이 Ad 단백질은 이 및 유사한 목적을 위한 사용에 사용될 수도 있다.
또 다른 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 아데노바이러스 단백질은, 당업자에게 쉽게 분명해질 다양한 목적을 위해, 단독으로, 또는 다른 아데노바이러스 단백질과 조합하여 사용될 수도 있다. 게다가, SAdV 아데노바이러스 단백질에 대한 또 다른 사용은 당업자에게 쉽게 분명해질 것이다.
II. 재조합 아데노바이러스 벡터
본원에서 설명된 조성물은, 치료 또는 백신 목적을 위해, 이종 기원 분자를 세포에 전달하는 벡터를 포함한다. 본원에서 사용된 바와 같이, 벡터는, 제한 없이, 네이키드 DNA, 파지(phage), 트랜스포손(transposon), 코스미드, 에피솜, 플라스미드, 또는 바이러스를 포함하는 어떤 유전적 요소도 포함할 수 있다. 이러한 벡터는 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 의 원숭이 아데노바이러스 DNA 및 꼬마유전자(minigene)를 함유한다. "꼬마유전자" 또는 "발현 카세트"는 선택된 이종 기원 유전자 및 숙주 세포에서 유전자 생성물의 번역, 전사 및/또는 발현을 지시하는데 필요한 다른 조절 요소의 조합을 의미한다.
전형적으로, SAdV-A1302-, SAdV-A1320-, SAdV-A1331-, 또는 SAdV-A1337 -유래된 아데노바이러스 벡터는 꼬마유전자가 선택된 아데노바이러스 유전자에 고유한 영역에서 다른 아데노바이러스 서열을 함유하는 핵산 분자에 위치하도록 설계된다. 꼬마유전자는 원하면, 상기 영역의 기능을 방해하기 위해 기존의 유전자 영역으로 삽입될 수도 있다. 대안으로, 꼬마유전자는 부분적으로 또는 완전히 결실된 아데노바이러스 유전자의 부위로 삽입될 수도 있다. 예를 들어, 꼬마유전자는, 선택될 수도 있는 다른 것들 중에서, 기능적 E1 결실 또는 기능적 E3 결실의 부위와 같은 부위에 위치할 수도 있다. 용어 "기능적으로 결실된" 또는 "기능적 결실"은, 유전자 발현의 기능적 생성물의 생산이 더 이상 가능하지 않도록, 예를 들어, 돌연변이 또는 변형에 의해 충분한 양의 유전자 영역이 제거되거나 그렇지 않으면 손상된다는 것을 의미한다. 원하면, 전체 유전자 영역이 제거될 수도 있다. 유전자 붕괴 또는 결실에 적합한 다른 부위가 본 출원의 다른 곳에서 논의된다.
예를 들어, 재조합 바이러스의 생성에 유용한 생산 벡터에 대하여, 벡터는 꼬마유전자 및 아데노바이러스 게놈의 5' 끝 또는 아데노바이러스 게놈의 3' 끝, 또는 아데노바이러스 게놈의 5' 및 3' 끝 둘 다를 함유할 수도 있다. 아데노바이러스 게놈의 5' 끝은 포장 및 복제에 필요한 5' 씨스-요소, 즉, 5' 역위 말단 반복 부위 (ITR) 서열 (복제의 기원으로서 기능함) 및 고유한 5' 포장 인핸서(enhancer) 도메인 (선형 Ad 게놈 및 E1 프로모터에 대한 인핸서 요소를 포장하는데 필요한 서열을 함유함)를 함유한다. 아데노바이러스 게놈의 3' 끝은 포장 및 캡시드화에 필요한 3' 씨스-요소 (ITR 포함)를 포함한다. 적합하게, 재조합 아데노바이러스는 5' 및 3' 아데노바이러스 씨스-요소 둘 다를 함유하고 꼬마유전자는 5' 및 3' 아데노바이러스 서열 사이에 위치한다. SAdV-A1302-, SAdV-A1320-, SAdV-A1331-, 또는 SAdV-A1337 -기반 아데노바이러스 벡터는 또한 추가적인 아데노바이러스 서열을 함유할 수도 있다.
적합하게, 이 SAdV-A1302-, SAdV-A1320-, SAdV-A1331-, 또는 SAdV-A1337 -기반 아데노바이러스 벡터들은 본 발명의 아데노바이러스 게놈으로부터 유래된 하나 이상의 아데노바이러스 요소를 함유한다. 한 구체예에서, 벡터는 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 의 아데노바이러스 ITR 및 같은 아데노바이러스 혈청형의 추가적인 아데노바이러스 서열을 함유한다. 또 다른 구체예에서, 벡터는 ITR을 제공하는 것과 다른 아데노바이러스 혈청형으로부터 유래된 아데노바이러스 서열을 함유한다.
본원에서 정의된 바와 같이, 위형(pseudotyped) 아데노바이러스는 아데노바이러스의 캡시드 단백질이 ITR을 제공하는 아데노바이러스와 다른 아데노바이러스의 것인 아데노바이러스를 나타낸다.
게다가, 키메라 또는 하이브리드 아데노바이러스는 당업자들에게 알려져 있는 기술을 사용하여 본원에서 설명된 아데노바이러스를 사용하여 구성될 수도 있다. 예를 들어, 제US 7,291,498호를 참고하면 된다.
ITR의 아데노바이러스 공급원 및 벡터에 존재하는 어떤 다른 아데노바이러스 서열의 공급원의 선택은 본 구체예의 제한이 아니다. 다양한 아데노바이러스 균주는 버지니아주 매너서스의 American Type Culture Collection으로부터 이용 가능하거나, 또는 다양한 상업적 및 기관적 공급원으로부터의 요청에 의해 이용 가능하다. 게다가, 이러한 많은 균주의 서열은, 예를 들어, PubMed 및 GenBank를 포함하는 다양한 데이터베이스로부터 이용 가능하다. 다른 원숭이 또는 인간 아데노바이러스로부터 제조된 상동성 아데노바이러스 벡터는 공개된 문헌에서 설명된다 [예를 들어, 미국 특허 번호 제5,240,846호를 참고하면 된다]. 많은 아데노바이러스 타입의 DNA 서열이 GenBank로부터 이용 가능하며, 타입 Ad5 [GenBank 수납 번호 M73370]를 포함한다. 아데노바이러스 서열은 혈청형 2, 3, 4, 7, 12 및 40과 같이, 어떤 알려진 아데노바이러스 혈청형으로부터 얻어질 수도 있고, 현재 확인된 인간 타입 중 어떤 것도 더 포함할 수 있다. 유사하게 비-인간 동물 (예를 들어, 원숭이)를 감염시키는 것으로 알려져 있는 아데노바이러스는 또한 본 발명의 벡터 구조에서 활용될 수도 있다. 예를 들어, 미국 특허 번호 제6,083,716을 참고하면 된다.
바이러스 서열, 도우미 바이러스 (필요하면), 재조합 바이러스 입자, 및 본원에서 설명된 벡터의 구성에 활용된 다른 벡터 구성요소 및 서열은 상기 설명된 바와 같이 얻어진다. 본 발명의 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 원숭이 아데노바이러스의 DNA 서열은 이러한 벡터의 제조에 유용한 벡터 및 세포를 구성하는데 활용된다.
서열 결실, 삽입, 및 다른 돌연변이를 포함하는, 본 발명의 벡터를 형성하는 핵산 서열의 변형은 표준 분자 생물학적 기술을 사용하여 생성될 수도 있고 이 구체예의 범위 내에 있다.
A. "꼬마유전자"
전이 유전자의 선택에 활용된 방법, "꼬마유전자"의 클로닝 및 구성 및 그것의 바이러스 벡터로의 삽입은 본원에서 제공된 교시내용에 제공된 업계의 기술 내에 있다.
I. 전이 유전자
전이 유전자는 핵산 서열로서, 전이 유전자를 플랭킹하는 벡터 서열에 대하여 이종 기원이며, 이것은 원하는 폴리펩티드, 단백질, 또는 다른 생성물을 암호화한다. 핵산 암호화 서열은 숙주 세포에서 전이 유전자 전사, 번역, 및/또는 발현을 허용하는 방식으로 조절 구성요소에 작동 가능하게 결합된다.
전이 유전자 서열의 조성물은 결과의 벡터가 배치될 사용에 기초할 것인데, 예를 들어, 한 타입의 전이 유전자 서열은 리포터 서열을 포함하며, 이것은 발현시 검출 가능한 신호를 생산한다. 이러한 리포터 서열은, 제한 없이, β-락타마제, β-갈락토시다제 (LacZ), 알칼린 포스파타제, 티미딘 키나제, 녹색 형광 단백질 (GFP), 클로람페니콜 아세틸트랜스퍼라제 (CAT), 루시퍼라제, 예를 들어, CD2, CD4, CD8을 포함하는 막 결합 단백질, 인플루엔자 헤마글루티닌 단백질, 및 업계에 잘 알려진 다른 것들을 암호화하는 DNA 서열을 포함하며, 그것에 관련된 고친화도 항체가 존재하거나 통상적인 수단에 의해 생산될 수 있고, 다른 것들 중에 헤마글루티닌 또는 Myc의 항원 태그 도메인에 적절하게 융합된 막 결합 단백질을 포함한다. 이 암호화 서열들은, 그것들의 발현을 지시하는 조절 요소와 결합될 때, 효소적, 방사선 사진, 비색적, 형광 발광 또는 다른 다른 분광 사진 검정, 형광 활성화 세포 구분 검정 및 효소 결합 면역 흡착 검정 (ELISA), 방사 면역 검정 (radioimmunoassay; RIA) 및 면역 조직 화학법을 포함하는 면역학적 검정을 포함하는 통상적인 수단에 의해 검출 가능한 신호를 제공한다. 예를 들어, 마커 서열이 LacZ 유전자인 경우, 신호를 가지고 있는 벡터의 존재는 베타-갈락토시다제 활성에 대한 검정에 의해 검출된다. 전이 유전자가 GFP 또는 루시퍼라제인 경우에는, 신호를 가지고 있는 벡터가 광도계에서의 색 또는 빛 생산에 의해 시각적으로 측정될 수도 있다.
한 구체예에서, 전이 유전자는 단백질, 펩티드, RNA, 효소, 또는 촉매 RNA와 같이, 생물학 및 의학에서 유용한 생성물을 암호화하는 비-마커 서열이다. 바람직한 RNa 분자는 tRNA, dsRNA, 리보솜 RNA, 촉매 RNAs, 및 안티센스 RNA를 포함한다. 유용한 RNA 서열의 한 예는 치료된 동물에서 표적화된 핵산 서열의 발현을 끝내는 서열이다.
전이 유전자는 면역 반응을 유발하기 위해, 및/또는 예방적 백신 목적을 위해, 예를 들어, 유전적 결핍의 치료에, 항암제 또는 백신으로서, 사용될 수도 있다. 본원에서 사용된 바와 같이, 면역 반응의 유발은 분자(예를 들어, 유전자 생성물)에 대한 T 세포 및/또는 체액 면역 반응을 유발하는 분자의 능력을 나타낸다. 본 발명은, 예를 들어, 다중-서브유닛 단백질에 의해 유발된 조건을 정정하거나 개선하기 위해 다중 전이 유전자의 사용을 더 포함한다. 특이적인 경우에, 다른 전이 유전자는 단백질의 각 서브유닛을 암호화하기 위해, 또는 다른 펩티드 또는 단백질을 암호화하기 위해 사용될 수도 있다. 이것은 단백질 서브유닛을 암호화하는 DNA의 크기가, 예를 들어, 면역글로불린, 혈소판-유래된 성장 인자, 또는 디스트로핀 단백질에 대하여 클 때 바람직하다. 세포가 다중-서브유닛 단백질을 생산하기 위해, 세포는 다른 서브유닛 각각을 함유하는 재조합 바이러스로 감염된다. 대안으로, 단백질의 다른 서브유닛은 같은 전이 유전자에 의해 암호화될 수도 있다. 이 경우에, 단일 전이 유전자는 각각의 서브유닛을 암호화하는 DNA를 포함하며, 각 서브유닛에 대한 DNA는 내부 리보자임 진입 부위 (internal ribozyme entry site; IRES)에 의해 분리된다. 이것은 각각의 서브유닛을 암호화하는 DNA의 크기가 작을 때, 예를 들어, 서브유닛을 암호화하는 DNA 및 IRES의 총 크기가 5 킬로베이스보다 작을 때 바람직하다. IRES에 대한 대안으로서, DNA는 2A 펩티드를 암호화하는 서열에 의해 분리될 수도 있으며, 이것은 번역 후 이벤트에서 자가-분할한다. 예를 들어, M.L. Donnelly, et al, J. Gen. Virol, 78(Pt 1): 13-21 (Jan 1997); Furler, S., et al, Gene Ther., 8(11):864-873 (June 2001); Klump H, et al, Gene Ther., 8(10):811-817 (May 2001)을 참고하면 된다. 이 2A 펩티드는 IRES보다 훨씬 더 작으며, 그것을 공간이 제한 인자일 때의 사용에 적합하게 만든다. 하지만, 선택된 전이 유전자는 어떤 생물학적 활성 생성물 또는 다른 생성물, 예를 들어, 연구에 바람직한 생성물도 암호화할 수도 있다.
적합한 전이 유전자는 당업자에 의해 쉽게 선택될 수도 있다. 전이 유전자의 선택은 본 구체예의 제한으로 간주되지 않는다.
2. 조절 요소
꼬마유전자에 대하여 상기 확인된 주요 요소 이외에, 벡터는 또한 플라스미드 벡터로 트랜스펙션되거나 본 발명에 의해 생산된 바이러스로 감염된 세포에서 전사, 번역 및/또는 발현을 허용하는 방식으로 전이 유전자에 작동 가능하게 결합된 필수적인 통상적 제어 요소를 포함한다. 본원에서 사용된 바와 같이, "작동 가능하게 결합된" 서열은 원하는 유전자와 인접한 발현 제어 서열 및 인 트랜스 또는 멀리서 작동하여 원하는 유전자를 제어하는 발현 제어 서열 둘 다를 포함한다.
발현 제어 서열은 적절한 전사 시작, 종결, 프로모터 및 인핸서 서열; 토끼 베타-글로빈 폴리A를 포함하는 스플라이싱(splicing) 및 폴리아데닐화 (폴리 A) 신호와 같이 효과적인 RNA 가공 신호; 세포질 mRNA를 안정화하는 서열; 번역 효율을 향상시키는 서열 (예를 들어, 코자크 공통 서열(Kozak consensus sequence)); 단백질 안정성을 향상시키는 서열; 및 원할 때, 암호화된 생성물의 분비를 향상시키는 서열을 포함한다. 다른 서열 중에서, 키메라 인트론이 사용될 수도 있다.
고유한, 구성적, 유발성 및/또는 조직-특이적인 프로모터를 포함하는, 많은 발현 제어 서열이 업계에 알려져 있고 이용될 수도 있다. 구성적 프로모터의 예는, 제한 없이, TBG 프로모터, 레트로바이러스 라우스 육종 바이러스 (Rous sarcoma virus; RSV) LTR 프로모터 (선택적으로 RSV 인핸서와 함께), 시토메갈로바이러스 (시토메갈로바이러스; CMV) 프로모터 (선택적으로 CMV 인핸서와 함께) [예를 들어, Boshart et al, Cell, 41:521-530 (1985)를 참고하면 된다], SV40 프로모터, 디히드로폴레이트 리덕타제 프로모터, β-액틴 프로모터, 포스포글리세롤 키나제 (PGK) 프로모터, 및 EF1α 프로모터 [Invitrogen]를 포함한다.
유발성 프로모터는 유전자 발현의 조절을 허용하며 외인성 공급된 화합물, 온도와 같은 환경적 인자, 또는 특정 생리학적 상태, 예를 들어, 급성기, 세포의 특정 분화 상태의 존재에 의해, 또는 세포의 복제시에만 조절될 수 있다. 유발성 프로모터 및 유발 시스템은 다양한 상업적 공급원으로부터 이용 가능하며, 제한 없이, Invitrogen, Clontech 및 Ariad를 포함한다. 많은 다른 시스템이 설명되었고 당업자에 의해 쉽게 선택될 수 있다. 예를 들어, 유발성 프로모터는 아연-유발성 양 메탈로티오닌 (MT) 프로모터 및 덱사메타손 (Dex)-유발성 마우스 유방암 바이러스 (MMTV) 프로모터를 포함한다. 다른 유발 시스템은 T7 폴리머라제 프로모터 시스템 [제WO 98/10088호]; 엑다이손 곤충 프로모터 [No et al, Proc. Natl. Acad. Sci. USA, 93:3346-3351 (1996)], 테트라사이클린-억제 시스템 [Gossen et al, Proc. Natl. Acad. Sci. USA, 89:5547-5551 (1992)], 테트라사이클린-유발 시스템 [Gossen et al, Science, 378:1766-1769 (1995), 또한 Harvey et al, Curr. Opin. Chem. Biol, 2:512-518 (1998)을 참고하면 된다]을 포함한다. 다른 시스템은, 카스트라디올, 디페놀 뮤리슬레론, RU486-유발 시스템 [Wang et al, Nat. Biotech., 15:239-243 (1997) 및 Wang et al, Gene Ther., 4:432-441 (1997)] 및 라파마이신-유발 시스템 [Magari et al, J. Clin. Invest., 100:2865-2872 (1997)]을 사용하는, FK506 다이머, VP16 또는 p65를 포함한다. 일부 유발성 프로모터의 유효성은 시간이 지남에 따라 증가한다. 이러한 경우에, 탠덤에서 다중 억제자, 예를 들어, IRES에 의해 TetR에 결합된 TetR을 삽입함으로써 이러한 시스템의 유효성을 향상시킬 수 있다. 대안으로, 원하는 기능에 대하여 스크리닝 전 적어도 3일을 기다릴 수 있다. 이 시스템의 유효성을 향상시키기 위해 알려진 수단에 의해 원하는 단백질의 발현을 향상시킬 수 있다. 예를 들어, 우드척 간염 바이러스 전사 후 조절 요소 (Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element; WPRE)를 사용한다.
또 다른 구체예에서, 전이 유전자에 대한 고유 프로모터가 사용될 것이다. 고유 프로모터는 전이 유전자의 발현이 고유 발현을 모방해야 하는 것이 요구될 때 바람직할 수도 있다. 고유 프로모터는 전이 유전자의 발현이 일시적으로 또는 발전적으로, 또는 조직-특이적 방식으로, 또는 특이적 전사 자극에 반응하여 조절되어야 할 때 사용될 수도 있다. 추가의 구체예에서, 인핸서 요소, 폴리아데닐화 부위 또는 코자크 공통 서열과 같은, 다른 고유 발현 제어 요소들은 또한 고유한 발현을 모방하기 위해 사용될 수도 있다.
전이 유전자의 또 다른 구체예는 조직-특이적 프로모터에 작동 가능하게 결합된 전이 유전자를 포함한다. 예를 들어, 골격근에서 발현이 요구될 때, 근육에서 활성인 프로모터가 사용되어야 한다. 이것들은 골격 β-액틴, 미오신 경쇄 2A, 디스트로핀, 근육 크레아틴 키나제를 암호화하는 유전자의 프로모터, 뿐만 아니라 활성이 자연 발생 프로모터보다 더 높은 합성 근육 프로모터를 포함한다 (Li et al, Nat. Biotech., 17:241-245 (1999)를 참고하면 된다). 조직-특이적인 프로모터의 예는, 다른 것들 중에서, 간 (알부민, Miyatake et al, J. Virol, 71:5124-32 (1997); B형 간염 바이러스 코어 프로모터, Sandig et al, Gene Ther., 3:1002-9 (1996); 알파-페토단백질 (AFP), Arbuthnot et al., Hum. Gene Ther., 7: 1503-14 (1996)), 뼈 오스테오칼신 (Stein et al, Mol. Biol. Rep., 24:185-96 (1997)); 뼈 시알로단백질 (Chen et al., J. Bone Miner. Res., 11:654-64 (1996)), 림프구 (CD2, Hansal et al, J. Immunol, 161:1063-8 (1998); 면역글로불린 중쇄; T 세포 수용체 사슬, neuronal such as 뉴런-특이적 에놀라제 (NSE) 프로모터 (Andersen et al, Cell. Mol. Neurobiol, 13:503-15 (1993)), 신경필라멘트(neurofilament) 경쇄 유전자 (Piccioli et al, Proc. Natl. Acad. Sci. USA, 88:5611-5 (1991)), 및 뉴런-특이적 vgf 유전자 (Piccioli et al, Neuron, 15:373-84 (1995))에 대하여 알려져 있다.
선택적으로, 치료적으로 유용한 또는 면역원성 생성물을 암호화하는 전이 유전자를 가지고 있는 벡터는 또한 선택 가능한 마커를 포함할 수도 있거나 리포터 유전자는, 다른 것들 중에서, 제네티신, 히그로마이신 또는 퓨리마이신 내성을 암호화하는 서열을 포함할 수도 있다. 이러한 선택 가능한 리포터 또는 마커 유전자 (바람직하게 바이러스 입자로 포장되도록 바이러스 게놈의 외부에 위치함)는 앰피실린 내성과 같이, 박테리아 세포에서 플라스미드의 존재를 알리기 위해 사용될 수 있다. 벡터의 다른 구성요소는 복제의 기원을 포함할 수도 있다. 여러 프로모터 및 벡터 요소의 선택은 통상적이며 이러한 많은 서열이 이용 가능하다 [예를 들어, Sambrook et al, 및 본원에서 인용된 참고문헌을 참고하면 된다].
이 벡터들은, 당업자들에게 알려져 있는 기술과 함께, 본원에서 제공된 기술 및 서열을 사용하여 생성된다. 이 기술들은 본문에서 설명된 것들과 같이 cDNA의 통상적인 클로닝 기술 [Sambrook et al, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, Cold Spring Harbor, NY], 아데노바이러스 게놈의 중첩 올리고뉴클레오티드 서열의 사용, 폴리머라제 연쇄 반응, 및 원하는 뉴클레오티드 서열을 제공하는 어떤 적합한 방법도 포함한다.
III. 바이러스 벡터의 생산
한 구체예에서, 원숭이 아데노바이러스 플라스미드 (또는 다른 벡터)는 아데노바이러스 벡터를 생산하기 위해 사용된다. 한 구체예에서, 아데노바이러스 벡터는 복제-결함이 있는 아데노바이러스 입자이다. 한 구체예에서, 아데노바이러스 입자는 E1a 및/또는 E1b 유전자의 결실에 의해 복제-결함으로 만들어진다. 대안으로, 아데노바이러스는 또 다른 수단에 의해 복제-결함으로 만들어지는 한편, 선택적으로는 E1a 및/또는 E1b 유전자를 유지한다. 유사하게, 일부 구체예에서는, 벡터에 대한 면역 반응의 감소가 E2b 및/또는 DNA 폴리머라제 유전자의 결실에 의해 달성될 수도 있다. 아데노바이러스 벡터는 또한 아데노바이러스 게놈에 대한 다른 돌연변이, 예를 들어, 온도-민감성 돌연변이 또는 다른 유전자의 결실을 함유할 수 있다. 다른 구체예에서, 아데노바이러스 벡터에서 온전한 E1a 및/또는 E1b 영역을 유지하는 것이 바람직하다. 이러한 온전한 E1 영역은 아데노바이러스 게놈에서 그것의 고유한 위치에 위치하거나 고유한 아데노바이러스 게놈의 결실 부위 (예를 들어, E3 영역)에서 배치될 수도 있다.
유전자의 인간 (또는 다른 포유동물) 세포에 전달하는데 유용한 원숭이 아데노바이러스 벡터의 구조에서, 아데노바이러스 핵산 서열의 범위는 벡터에서 이용될 수 있는데. 예를 들어, 예를 들어, 아데노바이러스 지연 초기 발현 유전자 E3 모두 또는 일부는 재조합 바이러스의 일부를 형성하는 원숭이 아데노바이러스 서열로부터 제거될 수도 있다. 원숭이 E3의 기능은 재조합 바이러스 입자의 기능 및 생산과 무관한 것으로 생각된다. E4 유전자의 적어도 ORF6 영역의 결실을 갖는 원숭이 아데노바이러스 벡터가 또한 구성될 수도 있으며, 더 바람직하게는 이 영역, 전체 E4 영역의 기능의 중복 때문이다. 본 발명의 또 다른 벡터는 지연된 초기 발현 유전자 E2a의 결실을 함유한다. 결실은 또한 원숭이 아데노바이러스 게놈의 후기 발현 유전자 L1 내지 L5 중 어떤 것에서도 만들어질 수 있다. 유사하게, 중간 발현 유전자(intermediate gene) IX 및 IVa2의 결실은 어떤 목적을 위해 유용할 수도 있다. 다른 결실은 다른 구조 또는 비-구조 아데노바이러스 유전자에서 만들어질 수도 있다. 상기 논의된 결실은 개별적으로 사용될 수도 있는데, 즉, 본원에서 설명된 바와 같이 사용되는 아데노바이러스 서열은 단일 영역에서만 결실을 함유할 수도 있다. 대안으로, 생물학적 활성을 파괴하는데 효과적인 전체 유전자 또는 이것들의 일부의 결실은 어떤 조합으로도 사용될 수 있다. 예를 들어, 하나의 예시적 벡터에서, 아데노바이러스 서열은 E1 유전자 및 E4 유전자, 또는 E1, E2a 및 E3 유전자, 또는 E1 및 E3 유전자, 또는 E3의 결실과 함께 또는 없이, E1, E2a 및 E4 유전자의 결실, 등을 가질 수도 있다. 상기 논의된 바와 같이, 이러한 결실은 원하는 결과를 달성하기 위해 다른 돌연변이, 예를 들어, 온도-민감성 돌연변이와 함께 사용될 수도 있다.
어떤 필수 아데노바이러스 서열 (예를 들어, E1a, E1b, E2a, E2b, E4 ORF6, LI, L2, L3, L4 및 L5)이 결핍된 아데노바이러스 벡터도 아데노바이러스 입자의 바이러스 감염성 및 증식에 필요한 손실 아데노바이러스 유전자 생성물의 존재시 배양될 수 있다. 이 도우미 기능들은 하나 이상의 도우미 구조 (예를 들어, 플라스미드 또는 바이러스) 또는 포장 숙주 세포의 존재시 아데노바이러스 벡터를 배양함으로써 제공될 수도 있다. 예를 들어, 기술은 1996년 5월 9일에 공개되고, 본원에서 참고로 포함되는 국제 특허 출원 제W096/13597호에서 "최소" 인간 Ad 벡터의 제조에 대하여 설명하였다.
I. 도우미 바이러스
따라서, 꼬마유전자를 운반하기 위해 이용된 바이러스 벡터의 원숭이 아데노바이러스 유전자 함량에 따라, 도우미 아데노바이러스 또는 비-복제 바이러스 단편은 꼬마유전자를 함유하는 감염성 재조합 바이러스 입자를 생산하는데 필요한, 충분한 원숭이 아데노바이러스 유전자 서열을 제공하는데 필요할 수도 있다. 유용한 도우미 바이러스는 아데노바이러스 벡터 구조에 존재하지 않고 및/또는 벡터가 트랜스펙션된 포장 세포주에 의해 발현되지 않는, 선택된 아데노바이러스 유전자 서열을 함유한다. 한 구체예에서, 도우미 바이러스는 복제-결함이 있고 상기 설명된 서열 이외에 다양한 아데노바이러스 유전자를 함유한다. 도우미 바이러스는 바람직하게 E1-발현 세포주와 함께 사용된다.
도우미 바이러스는 Wu et al, J. Biol. Chem., 374:16985-16987 (1989); K. J. Fisher and J. M. Wilson, Biochem. J., 299:49 (1994년 4월 1일)에서 설명된 바와 같이 다중-양이온 컨쥬게이트로 형성될 수도 있다. 도우미 바이러스는 선택적으로 제2 리포터 꼬마유전자를 함유할 수도 있다. 이러한 많은 리포터 유전자가 업계에 알려져 있다. 아데노바이러스 벡터에서 전이 유전자와 다른 도우미 바이러스에서 리포터 유전자의 존재는 Ad 벡터 및 도우미 바이러스 둘 다가 독립적으로 관찰되게 한다. 이 제2 리포터는 정제시 결과의 재조합 바이러스 및 도우미 바이러스 사이에서 분리를 가능하게 하는데 사용된다.
2. 상보성 세포주
상기 설명된 유전자 중 어떤 것에서도 결실되는 재조합 원숭이 아데노바이러스 (Ad)를 생성하기 위해, 결실된 유전자 영역의 기능은, 바이러스의 복제 및 감염성에 필수적이면, 도우미 바이러스 또는 세포주, 즉, 상보성 또는 포장 세포주에 의해 재조합 바이러스에 공급되어야 한다. 많은 경우에, 인간 E1을 발현하는 세포주는 침팬지 Ad 벡터를 트랜스보충(transcomplement)하는데 사용될 수 있다. 이것은 특히 이로운데, 본 발명의 침팬지 Ad 서열과 현재 이용 가능한 포장 세포에서 발견된 인간 AdE1 서열 사이의 다양성으로 인해, 현재 인간 E1-함유 세포의 사용은 복제 및 생산 과정 중에 복제-컴피턴트(competent) 아데노바이러스의 생성을 방지하기 때문이다. 하지만, 특정 경우에서, E1-결실된 원숭이 아데노바이러스의 생산에 활용될 수 있는 E1 유전자 생성물을 발현하는 세포주를 활용하는 것이 바람직할 것이다. 이러한 세포주가 설명되었다. 예를 들어, 미국 특허 제6,083,716호를 참고하면 된다.
원하는 경우에, 선택된 모체 세포주에서 발현되는 프로모터의 전사 제어 하에 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 의 아데노바이러스 E1 유전자를, 최소한으로, 발현하는 포장 세포 또는 세포주를 생성하기 위해 본원에서 제공된 서열을 활용할 수도 있다. 유발성 또는 구성적 프로모터는 이 목적을 위해 이용될 수도 있다. 이러한 프로모터의 예는 본 출원의 다른 곳에서 더 상세히 설명된다. 모체 세포는 어떤 원하는 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 유전자를 발현하는 새로운 세포주의 발현을 위해 선택된다. 제한은 아니지만, 이러한 모체 세포주는, 다른 것들 중에서, HeLa [ATCC 수납 번호 CCL 2], A549 [ATCC 수납 번호 CCL 185], HEK 293, KB [CCL 17], Detroit [예를 들어, Detroit 510, CCL 72] 및 WI-38 [CCL 75] 세포일 수도 있다. 이 세포주들은 모두 버지니아 20110-2209 매너서스 대학로 10801의 American Type Culture Collection으로부터 이용 가능하다. 다른 적합한 모체 세포주는 다른 공급원으로부터 얻을 수도 있다.
이러한 E1-발현 세포주는 재조합 원숭이 아데노바이러스 E1 결실된 벡터의 생성에 유용하다. 추가적으로, 또는 대안으로, 하나 이상의 원숭이 아데노바이러스 유전자 생성물, 예를 들어, E1a, E1b, E2a, 및/또는 E4 ORF6을 발현하는 세포주는 재조합 원숭이 바이러스 벡터의 생성에 사용된, 본질적으로 같은 과정을 사용하여 구성될 수 있다. 이러한 세포주는 상기 생성물을 암호화하는 필수 유전자에서 결실된 아데노바이러스 벡터를 트랜스보충하기 위해, 또는 도우미-의존 바이러스 (예를 들어, 아데노-연관 바이러스)의 포장에 필요한 도우미 기능을 제공하기 위해 활용될 수 있다. 숙주 세포의 제조는 선택된 DNA 서열의 조립과 같은 기술을 수반한다. 이 조립은 통상적인 기술을 사용하여 성취될 수도 있다. 이러한 기술은 잘 알려져 있고 상기 인용된 Sambrook et al.에서 설명된 cDNA 및 게놈 클로닝, 폴리머라제 연쇄 반응으로 결합된, 아데노바이러스 게놈의 중첩 올리고뉴클레오티드 서열의 사용, 합성 방법, 및 원하는 뉴클레오티드 서열을 제공하는 어떤 다른 적합한 방법도 포함한다.
또 다른 대안에서, 필수 아데노바이러스 유전자 생성물이 아데노바이러스 벡터 및/또는 도우미 바이러스에 의해 인 트랜스 제공된다. 이러한 경우에서, 적합한 숙주 세포는 어떤 생물학적 유기체로부터 선택될 수 있으며, 원핵 생물 (예를 들어, 박테리아) 세포, 및 곤충 세포, 효모 세포 및 포유동물 세포를 포함하는 진핵생물을 포함한다. 특히 바람직한 숙주 세포는 어떤 포유동물 종 중에서 선택되며, 제한 없이, A549, WEHI, 3T3, 10T1/2, HEK 293 세포 또는 PERC6 (이것들 둘 다 기능적 아데노바이러스 E1을 발현함) [Fallaux, FJ et al, (1998), Hum Gene Ther, 9:1909-1917], Saos, C2C12, L 세포, HT1080, HepG2 및 인간, 원숭이, 마우스, 래트, 토끼, 및 햄스터를 포함하는 포유동물로부터 유래된 1차 섬유아세포, 간세포 및 근아세포를 포함한다. 세포를 제공하는 포유동물 종의 선택은 본 발명의 제한은 아니고; 포유동물 세포의 타입, 즉, 섬유아세포, 간세포, 종양 세포, 등도 아니다.
3. 바이러스 입자의 조립 및 세포주의 트랜스펙션
일반적으로, 트랜스펙션에 의해 꼬마유전자를 포함하는 벡터를 전달할 때, 벡터는 약 5 μg 내지 약 100 μg DNA, 및 바람직하게 약 10 내지 약 50 μg DNA의 양으로 약 1 x 104개의 세포 내지 약 1 x 1013개의 세포, 및 바람직하게 약 105개의 세포에 전달된다. 하지만, 숙주 세포에 대한 벡터 DNA의 상대적인 양은, 선택된 벡터, 전달 방법 및 선택된 숙주 세포와 같은 인자를 고려하여, 조정될 수도 있다.
벡터는 당업계에 알려져 있거나 상기 개시된 어떤 벡터일 수도 있으며, 네이키드 DNA, 플라스미드, 파지, 트랜스포손, 코스미드, 에피솜, 바이러스, 등을 포함한다. 벡터의 숙주 세포로의 도입은 업계에 알려져 있거나 또는 상기 개시된 어떤 수단에 의해서도 달성될 수도 있으며, 트랜스펙션, 및 감염을 포함한다. 아데노바이러스 유전자 중 하나 이상은 숙주 세포의 게놈으로 안정하게 통합되거나, 에피솜으로 안정하게 발현되거나, 또는 일시적으로 발현될 수도 있다. 유전자 생성물은 모두 에피솜에서 일시적으로 발현되거나 안정하게 통합되거나, 또는 유전자 생성물의 일부는 안정하게 발현되는 한편 다른 것들은 일시적으로 발현된다. 게다가, 각각의 아데노바이러스 유전자의 프로모터는 구성적 프로모터, 유발성 프로모터 또는 나이브 아데노바이러스 프로모터로부터 독립적으로 선택될 수도 있다. 프로모터는 유기체 또는 세포의 특이적 생리학적 상태에 의해 (즉, 분화 상태에 의해 또는 대체 또는 정지 세포에서) 또는 예를 들어, 외부로부터 추가된 인자에 의해 조절될 수도 있다.
분자 (플라스미드 또는 바이러스로서)의 숙주세포로의 도입은 또한 당업자에게 알려져 있고 명세서를 통해 논의된 기술을 사용하여 성취될 수도 있다. 바람직한 구체예에서, 표준 트랜스펙션 기술, 예를 들어, CaPO4 트랜스펙션 또는 전기천공법이 사용된다.
아데노바이러스의 선택된 DNA 서열 (뿐만 아니라 전이 유전자 및 다른 벡터 요소)의 다양한 중간 플라스미드로의 조립, 및 재조합 바이러스 입자를 생산하기 위한 플라스미드 및 벡터의 사용은 모두 통상적인 기술을 사용하여 달성된다. 이러한 기술은 텍스트에 설명된 것들과 같이 cDNA의 통상적인 클로닝 기술 [Sambrook et al, 상기 인용됨], 아데노바이러스 게놈의 중첩 올리고뉴클레오티드 서열의 사용, 폴리머라제 연쇄 반응, 및 워하는 뉴클레오티드 서열을 제공하는 어떤 적합한 방법도 포함한다. 표준 트랜스펙션 및 동시-트랜스펙션 기술이 이용되며, 예를 들어, CaPO4 침전 기술이 있다. 이용된 다른 통상적인 방법들은 바이러스 게놈의 상동 재조합, 한천 오버레이(overlay)에서 바이러스의 플라크(plaque), 신호 발생의 측정 방법, 등을 포함한다.
예를 들어, 꼬마유전자-함유 바이러스 벡터의 구성 및 조립 후, 벡터는 시험관 내에서 도우미 바이러스의 존재시 포장 세포주로 트랜스펙션된다. 상동 재조합이 도우미 및 벡터 서열 사이에서 발생하며, 이것은 벡터의 아데노바이러스-전이 유전자 서열이 복제되고 비리온 캡시드로 포장되게 하며, 재조합 바이러스 벡터 입자를 발생시킨다. 이러한 바이러스 입자를 생산하는 현재 방법은 트랜스펙션-기반이다. 하지만, 본 발명은 이러한 방법에 제한되지 않는다.
결과의 재조합 원숭이 아데노바이러스는 선택된 전이 유전자를 선택된 세포로 전송하는데 있어서 유용하다. 포장 세포주에서 키워진 재조합 바이러스로의 생체 내 실험에서, 본 발명의 E1-결실된 재조합 원숭이 아데노바이러스 벡터는 전이 유전자를 비-원숭이 세포, 바람직하게 인간 세포로 전송하는데 있어서의 유용성을 입증한다.
IV. 재조합 아데노바이러스 벡터의 사용
재조합 원숭이 아데노바이러스 A1302 (SAdV-A1302)-, SAdV-A1320-, SAdV-A1331-, 또는 SAdV-A1337 -기반 벡터는 시험관 내, 생체 외, 및 생체 내에서 인간 또는 비-원숭이 수의학적 환자로의 유전자 전송에 유용하다. 본원에서 설명된 재조합 아데노바이러스 벡터는 시험관 내에서 이종 기원 유전자에 의해 암호화된 생성물의 생산을 위한 발현 벡터로서 사용될 수 있다. 예를 들어, E1 결실의 위치로 삽입된 유전자를 함유하는 재조합 아데노바이러스는 상기 설명된 바와 같이 E1-발현 세포주로 트랜스펙션될 수도 있다. 대안으로, 복제-컴피턴트 아데노바이러스는 또 다른 선택된 세포주에서 사용될 수도 있다. 그 다음에 트랜스펙션된 세포는 통상적인 방식으로 배양되며, 재조합 아데노바이러스가 프로모터의 유전자 생성물을 발현하게 한다. 그 다음에 유전자 생성물은 단백질 분리 및 배양물로부터의 회수의 알려져 있는 통상적인 방법에 의해 배양 배지로부터 회수될 수도 있다.
SAdV-A1302-, SAdV-A1320-, SAdV-A1331-, 또는 SAdV-A1337 -유래된 재조합 원숭이 아데노바이러스 벡터는 유기체가 하나 이상의 AAV 혈청형에 대한 중화 항체를 갖는 경우에도 생체 내 또는 생체 외에서 선택된 전이 유전자를 선택된 숙주 세포에 전달할 수 있는 효율적인 유전자 전송 비히클을 제공한다. 한 구체예에서, rAAV 및 세포는 생체 외에서 혼합되고; 감염된 세포는 통상적인 방법론을 사용하여 배양되고; 변환된 세포는 환자에게 재주입된다. 이 조성물들은 보호 면역력을 유발하는 것을 포함하는 치료적 목적 및 면역화를 위한 유전자 전달에 특히 적합하다.
더 일반적으로는, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 재조합 아데노바이러스 벡터는 치료적 또는 면역원성 분자의 전달에 활용될 것이며, 하기 설명된 바와 같다. 두 가지 적용에 대하여, 본 발명의 재조합 아데노바이러스 벡터는 재조합 아데노바이러스 벡터의 반복 전달을 수반하는 요법에서 사용에 특히 적합하다는 것은 쉽게 이해될 것이다. 이러한 요법은 전형적으로 바이러스 캡시드가 대체되는 일련의 바이러스 벡터의 전달을 수반한다. 바이러스 캡시드는 각각 그 다음의 투여를 위해, 또는 미리 선택된 수 (예를 들어, 하나, 둘, 셋, 넷 이상)의 특정 혈청형 캡시드 투여 후에 변화될 수도 있다. 따라서, 요법은 제1 원숭이 캡시드를 가진 rAd의 전달, 제2 원숭이 캡시드를 가진 rAd와 함께 전달, 및 제3 원숭이 캡시드와 함께 전달을 수반할 수도 있다. 단독으로, 서로 조합하여, 또는 다른 아데노바이러스 (바람직하게 면역학적으로 비-교차반응성)와 조합하여, 본 발명의 Ad 캡시드를 사용하는 다양한 다른 요법은 당업자들에게 분명할 것이다. 선택적으로 이러한 요법은 본원에서 설명된 바와 같이 다른 비-인간 영장류 아데노바이러스, 인간 아데노바이러스, 또는 인공 서열의 캡시드를 가진 rAd의 투여를 수반할 수도 있다. 요법의 각 단계는 단일 Ad 캡시드로 일련의 주사 (또는 다른 전달 경로) 후 이어서 다른 Ad 공급원의 또 다른 캡시드로 일련의 주사의 투여를 수반할 수도 있다. 대안으로, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 벡터는, 다른 바이러스 시스템, 비-바이러스 전달 시스템, 단백질, 펩티드, 및 다른 생물학적 활성 분자를 포함하는, 다른 비-아데노바이러스-매개된 전달 시스템을 수반하는 요법에서 활용될 수도 있다.
다음 섹션은 본 발명의 아데노바이러스 벡터를 통해 전달될 수도 있는 예시적 분자에 초점을 맞출 것이다.
A. 치료적 분자의 Ad-매개된 전달
한 구체예에서, 상기-설명된 재조합 벡터는 유전자 치료를 위해 공개된 방법에 따라 인간에게 투여된다. 선택된 전이 유전자를 함유하는 원숭이 아데노바이러스 벡터는 환자에게 투여될 수도 있다. 바람직하게 생물학적으로 호환성 용액 또는 약학적으로 허용 가능한 전달 비히클(vehicle)에서 현탁된다. 적합한 비히클은 멸균 식염수를 포함한다. 약학적으로 허용 가능한 담체인 것으로 알려진 및 당업자에게 잘 알려져 있는 다른 수성 및 비-수성 등장성 멸균 주사용액 및 수성 및 비-수성 멸균 현탁액은 이 목적을 위해 이용될 수도 있다.
또한 분자를 표적 세포에 전달하는데 사용되는 본원에서 설명된 아데노바이러스 또는 재조합 아데노바이러스가 제공된다. 분자를 표적 세포에 전달하는데 유용한 의약품의 제조에 있어서 본원에서 설명된 아데노바이러스 재조합 아데노바이러스의 사용이 더 제공된다.
원숭이 아데노바이러스 벡터는 과도한 부작용 없이 또는 의학적으로 허용 가능한 생리학적 효과를 갖는 치료적 이익을 제공하기 위해 표적 세포를 변환하고 충분한 수준의 유전자 전송 및 발현을 제공하는데 충분한 양으로 투여되며, 이것은 의학계의 당업자에 의해 결정될 수 있다. 통상적이고 약학적으로 허용 가능한 투여 경로는 망막에 직접적인 전달 및 다른 안구 내 전달 방법, 간에 직접적인 전달, 흡입, 비강 내, 정맥 내, 근육 내, 기관 내, 피하, 피 내, 직장, 경구 및 다른 비경구 투여 경로를 포함하지만, 이에 제한되지 않는다. 투여 경로는, 원하면, 결합될 수도 있거나, 전이 유전자 또는 조건에 따라 조정될 수도 있다. 투여 경로는 주로 치료되는 조건의 성질에 따를 것이다.
바이러스 벡터의 투약량은 주로 치료되는 조건, 환자의 나이, 체중 및 건강과 같은 인자에 따를 것이며, 따라서 환자마다 다를 수도 있다. 예를 들어, 바이러스 벡터의 성체 인간 또는 수의학적 치료적 유효량은 일반적으로 약 1 x 106 내지 약 1 x 1015 입자, 약 1 x 1011 내지 1 x 1013 입자, 또는 약 1 x 109 내지 1 x 1012 입자 바이러스의 농도를 함유하는 담체의 약 100 내지 약 100 mL의 범위에 있다. 투약량은 동물의 크기 및 투여 경로에 따르는 범위에 있을 것이다. 예를 들어, 근육 내 주사를 위한 적합한 인간 또는 수의학적 투약량 (약 80 kg 동물)은 단일 부위에 대하여 mL 당 약 1 x 109 내지 약 5 x 1012 입자의 범위에 있다. 선택적으로, 다수의 투여 부위에 전달될 수도 있다. 또 다른 예에서, 적합한 인간 또는 수의학적 투약량은 경구 제형을 위해 약 1 x 1011 내지 약 1 x 1015의 범위에 있을 수도 있다. 당업자는, 투여 경로 및 재조합 벡터가 이용되는 치료적 또는 백신 적용에 따라, 이 용량을 조정할 수도 있다. 전이 유전자의 발현 수준, 또는 면역원에 대하여, 순환 항체의 수준은 투약량 투여의 빈도를 결정하기 위해 관찰될 수 있다. 그러나 투여의 빈도의 시기를 결정하는 다른 방법이 당업자에게 쉽게 분명해질 것이다.
선택적 방법 단계는 적합한 양의 단기 작용 면역 조절자의 바이러스 벡터와 동시에, 또는 이것의 투여 전에 또는 후에 환자에게 동시-투여를 수반한다. 선택된 면역 조절자는 본원에서 본 발명의 재조합 벡터에 대한 중화 항체의 형성을 억제할 수 있거나 벡터의 세포용해성 T 림프구 (CTL) 제거를 억제 할 수 있는 약제로서 정의된다. 면역 조절자는 T 도우미 서브세트 (TH1 또는 TH2) 및 B 세포 사이의 상호작용을 방해해서 중화 항체 형성을 억제할 수도 있다. 대안으로, 면역 조절자는 TH1 세포 및 CTL 사이의 상호작용을 억제하여 벡터의 CTL 제거의 발생을 감소시킬 수도 있다. 다양한 유용한 면역 조절자 및 같은 것의 사용을 위한 투약량이, 예를 들어, Yang et ah, J. Virol, 70(9) (1996년 9월); 1996년 5월 2일에 공개된 국제 PCT 특허 출원 번호 제WO96/12406호; 및 국제 특허 출원 번호 제PCT/US96/03035호에서 개시되며, 모두 본원에서 참고로 포함된다.
1. 치료적 전이 유전자
전이 유전자에 의해 암호화된 유용한 치료적 생성물은, 제한 없이, 인슐린, 글루카곤, 성장 호르몬 (GH), 부갑상선 호르몬 (PTH), 성장 호르몬 방출 인자 (GRF), 여포 자극 호르몬 (FSH), 황체 형성 호르몬 (LH), 인간 융모성 성선 자극 호르몬 (hCG), 혈관 내피 성장 인자 (VEGF), 안지오포이에틴, 안지오스타틴, 과립구 콜로니 자극 인자 (GCSF), 에리트로포이에틴 (EPO), 연결 조직 성장 인자 (CTGF), 염기성 섬유아세포 성장 인자 (bFGF), 산성 섬유아세포 성장 인자 (aFGF), 상피 성장 인자 (EGF), 형질전환 성장 인자 (TGF), 혈소판-유래된 성장 인자 (PDGF), 인슐린 성장 인자 I 및 II (IGF-I 및 IGF-II), TGF, 액티빈(actibin), 인히빈(inhibin)을 포함하는 형질전환 성장 인자 상과 중 어느 하나, 또는 뼈 형태형성 단백질 (BMP) BMP 1-15 중 어느 것, 성장 인자 중 heregluin/neuregulin/ARIA/neu 분화 인자 (NDF) 중 어느 하나, 신경 성장 인자 (NGF), 뇌-유래된 신경 영양 인자 (BDNF), 뉴로트로핀 NT-3 및 NT-4/5, 섬모 신경 영양 인자 (CNTF), 신경교세포주 유래된 신경 영양 인자 (GDNF), 뉴투린, 아그린, 세마포린/콜랍신의 과 중 어느 하나, 네트린-1 및 네트린-2, 간세포 성장 인자 (HGF), 에프린, 노긴, 소닉 헤지호그(sonic hedgehog) 및 티로신 히드록실라제를 포함하는, 호르몬 및 성장 및 분화 인자를 포함한다.
다른 유용한 전이 유전자 생성물은, 제한 없이, 트롬보포이에틴 (TPO), 인터류킨 (IL) IL-1 내지 IL-25 (예를 들어, IL-2, IL-4, IL-12 및 IL-18 등), 단핵구 화학주성 단백질, 백혈병(leukemia) 억제 인자, 과립-마크로파지 콜로니 자극 인자, Fas 리간드, 종양 괴사 인자 및, 인터페론과 같은 시토킨 및 림포킨, 및, 줄기 세포 인자, flk-2/flt3 리간드를 포함하는, 면역 시스템을 조절하는 단백질을 포함한다. 면역 시스템에 의해 생산된 유전자 생성물은 또한 본 발명에서 유용하다. 이것들은, 제한 없이, 면역글로불린 IgG, IgM, IgA, IgD 및 IgE, 키메라 면역글로불린, 인간화된 항체, 단일 사슬 항체, T 세포 수용체, 키메라 T 세포 수용체, 단일 사슬 T 세포 수용체, 등급 I 및 등급 II MHC 분자, 뿐만 아니라 조작된 면역글로불린 및 MHC 분자를 포함한다. 유용한 유전자 생성물은 또한 상보성 조절 단백질, 막 공통 인자 단백질 (MCP), 부패 가속화 인자 (DAF), CR1, CF2 및 CD59와 같은 상보성 조절 단백질을 포함한다.
또 다른 유용한 유전자 생성물은 호르몬, 성장 인자, 시토킨, 림포킨, 조절 단백질 및 면역 시스템 단백질에 대한 수용체 중 어느 하나를 포함한다. 본 발명은 저밀도 지방단백질 (LDL) 수용체, 고밀도 지방단백질 (HDL) 수용체, 초저밀도 지방단백질 (VLDL) 수용체, 및 스캐빈져(scavenger) 수용체를 포함하는, 콜레스테롤 조절을 위한 수용체를 포함한다. 본 발명은 또한 글루코코르티코이드 수용체 및 에스트로겐 수용체, 비타민 D 수용체 및 다른 핵 수용체를 포함하는 스테로이드 호르몬 수용체 상과의 멤버와 같은 유전자 생성물을 포함한다. 게다가, 유용한 유전자 생성물은 jun, fos, max, mad, 혈청 반응 인자 (SRF), AP-1, AP2, myb, MyoD 및 미오게닌, ETS-박스 함유 단백질, TFE3, E2F, ATF1, ATF2, ATF3, ATF4, ZF5, NFAT, CREB, HNF-4, C/EBP, SP1, CCAAT-박스 결합 단백질, 인터페론 조절 인자 (IRF-1), 빌름스 종양 단백질, ETS-결합 단백질, STAT, GATA-박스 결합 단백질, 예를 들어, GATA-3, 및 포크헤드(forkhead) 과의 윙드 나선형 단백질(winged helix protein)과 같은 전사 인자를 포함한다.
다른 유용한 유전자 생성물은 카바모일 신테타제 I, 오르니틴 트랜스카바밀라제, 아르기노숙시네이트 신테타제, 아르기노숙시네이트 리아제, 아르기나제, 푸마릴아세트아세테이트 히드로라제, 페닐알라닌 히드록실라제, 알파-1 안티트립신, 글루코스-6-포스파타제, 포포빌리노겐 데아미나제, 인자 VIII, 인자 IX, 시스타티온 베타-신타제, 분지형 사슬 케토산 데카르복실라제, 알부민, 이소발레릴-coA 데히드로게나제, 프로피오닐 CoA 카르복실라제, 메틸 말로닐 CoA 뮤타제, 글루타릴 CoA 데히드로게나제, 인슐린, 베타-글루코시다제, 피루베이트 카르복실레이트, 간 포스포릴라제, 포스포릴라제 키나제, 글리신 데카르복실라제, H-단백질, T-단백질, 낭포성 섬유증 막관통 조절기 (CFTR) 서열, 및 디스트로핀 cDNA 서열을 포함한다.
다른 유용한 유전자 생성물은 삽입, 결실 또는 아미노산 치환을 함유하는 비-자연 발생 아미노산 서열을 갖는 키메라 또는 하이브리드 폴리펩티드와 같은, 비-자연 발생 폴리펩티드를 포함한다. 예를 들어, 단일-사슬 조작된 면역글로불린은 특정 면역 손상된 환자에서 유용할 수 있다. 비-자연 발생 유전자 서열의 다른 타입은 안티센스 분자 및 리보자임과 같은 촉매 핵산을 포함하며, 이것은 표적의 과발현을 감소시키기 위해 사용될 수 있다.
유전자의 발현의 감소 및/또는 조절은 암 및 건선(건선)과 같이, 과증식 세포를 특징으로 하는 과증식 조건의 치료에 특히 바람직하다. 표적 폴리펩티드는 정상 세포와 비교하여 과증식 세포에서 독점적으로 또는 더 높은 수준으로 생산되는 상기 폴리펩티드를 포함한다. 표적 항원은 myb, myc, fyn과 같은 종양 유전자, 및 전위 유전자 bcr/abl, ras, src, P53, neu, trk 및 EGRF에 의해 암호화된 폴리펩티드를 포함한다. 표적 항원으로서 종양 유전자 생성물 이외에, 항-암 치료 및 보호 요법에 대한 표적 폴리펩티드는 B 세포 림프종에 의해 만들어진 항체의 가변 영역 및 일부 구체예에서는, 자가 면역 질환에 대한 표적 항원으로서 또한 사용되는 T 세포 림프종의 T 세포 수용체의 가변 영역을 포함한다. 다른 종양-관련 폴리펩티드는 단클론성 항체 17-1 A에 의해 인식된 폴리펩티드 및 폴레이트 결합 폴리펩티드를 포함하는, 종양 세포에서 더 높은수준으로 발견되는 폴리펩티드와 같은 표적 폴리펩티드로서 사용될 수 있다.
다른 적합한 치료적 폴리펩티드 및 단백질은 세포 수용체 및 자기-주도적 항체를 생산하는 세포를 포함하는 자가 면역에 관련된 표적에 대한 광범위한 보호적 면역 반응을 부여함으로써 자가 면역 질환 및 장애로부터 고통받는 개체를 치료하는데 유용할 수도 있는 것들을 포함한다. T 세포 매개된 자가 면역 질환은 류머티스성 관절염 (Rheumatoid arthritis; RA), 다발성 관절염 (multiple sclerosis; MS), 쇼그렌 증후군(Sjogren's syndrome), 유육종증(sarcoidosis), 인슐린 인슐린 의존형 당뇨병 (dependent diabetes mellitus; IDDM), 자가면역성 갑상선염(autoimmune thyroiditis), 반응성 관절염(reactive arthritis), 강직성 척추염(ankylosing spondylitis), 경피증(scleroderma), 다발성근염(polymyositis), 피부근염(dermatomyositis), 건선(psoriasis), 맥관염(vasculitis), 베게너 육아종증(Wegener's granulomatosis), 크론병(Crohn's disease) 및 궤양성 대장염(ulcerative colitis)을 포함한다. 이 질환들 각각은 내인성 항원에 결합하여 자가 면역 질환에 관련된 염증성 캐스케이드(cascade)를 시작하는 T 세포 수용체 (TCR)를 특징으로 한다.
본 발명의 원숭이 아데노바이러스 벡터는, 예를 들어, 같은 전이 유전자의 재전달을 수반하는 요법에서, 또는 다른 전이 유전자의 전달을 수반하는 조합 요법에서, 전이 유전자의 다수의 아데노바이러스-매개된 전달이 요구되는 치료 요법에 특히 적합하다. 이러한 요법은 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 원숭이 아데노바이러스 벡터의 투여 후, 이어서 같은 혈청형 아데노바이러스의 벡터의 재투여를 수반할 수도 있다. 특히 바람직한 요법은 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 원숭이 아데노바이러스 벡터의 투여를 수반하며, 제1 투여에서 전달된 벡터의 아데노바이러스 캡시드 서열의 공급원은 이후의 투여 중 하나 이상에서 활용된 바이러스 벡터의 아데노바이러스 캡시드 서열의 공급원과 다르다. 예를 들어, 치료 요법은 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 벡터의 투여 및 같거나 다른 혈청형의 하나 이상의 아데노바이러스 벡터의 반복 투여를 수반한다. 또 다른 예에서, 치료 요법은 아데노바이러스 벡터의 투여 후 이어서 처음 전달된 아데노바이러스 벡터의 캡시드 공급원과 다른 캡시드를 갖는 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 벡터의 반복 투여, 및 선택적으로 같거나, 또는 바람직하게는 이전 투여 단계에서 벡터의 아데노바이러스 캡시드 공급원과 다른 또 다른 벡터의 추가의 투여를 수반한다. 이 요법들은 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 원숭이 서열을 사용하여 구성된 아데노바이러스 벡터의 전달에 제한되지 않는다. 오히려, 이 요법들은 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 벡터와 조합하여, 제한 없이, 다른 원숭이 아데노바이러스 서열, (예를 들어, Pan9 또는 C68, C1 등), 다른 비-인간 영장류 아데노바이러스 서열, 또는 인간 아데노바이러스 서열을 포함하는 다른 아데노바이러스 서열들을 쉽게 활용할 수 있다. 이러한 운숭이, 다른 비-인간 영장류 및 인간 아데노바이러스 혈청형의 예는 이 문서의 다른 곳에서 논의된다. 게다가, 이 치료 요법들은 비-아데노바이러스 벡터, 비-바이러스 벡터, 및/또는 다양한 다른 치료적으로 유용한 화합물 또는 분자와 조합하여 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 아데노바이러스 벡터의 동시 또는 순차적 전달을 수반할 수도 있다. 본 발명은 이 치료 요법에 제한되지 않으며, 이것들 중 다수는 당업자에게 쉽게 분명해질 것이다.
B. 면역원성 전이 유전자의 Ad-매개된 전달
재조합 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 벡터는 면역원성 조성물로서 이용될 수도 있다. 본원에서 사용된 바와 같이, 면역원성 조성물은 체액 (예를 들어, 항체) 또는 세포 (예를 들어, 세포 독성 T 세포) 반응이 포유동물, 및 바람직하게 영장류에 전달 후 면역원성 조성물에 의해 전달된 전이 유전자에 대해 증가되는 조성물이다. 재조합 원숭이 Ad는 그것의 아데노바이러스 서열 결실 중 어느 것에서도 원하는 면역원을 암호화하는 유전자를 함유할 수 있다. 원숭이 아데노바이러스는 인간 기원의 아데노바이러스와 비교하여 다른 동물 종의 살아있는 재조합 바이러스 백신으로서 사용에 더 적합할 가능성이 크지만, 이러한 사용에 제한되지는 않는다. 재조합 아데노바이러스는 면역 반응의 유발에 결정적이고 병원체의 확산을 제한할 수 있는 항원이 확인되었고 cDNA가 이용 가능한 어떤 병원체에 대한 예방적 또는 치료적 백신으로서도 사용될 수 있다.
이러한 백신성 (또는 다른 면역원성) 조성물은 적합한 전달 비히클에서 제형화되며, 상기 설명된 바와 같다. 일반적으로, 면역원성 조성물의 용량은 치료적 조성물에 대하여 상기 정의된 범위에 있다. 선택된 유전자의 면역력의 수준은 촉진제에 대한 필요를, 있으면, 결정하기 위해 관찰될 수 있다. 혈청에서 항체 역가의 평가 후, 선택적 촉진제 면역화가 요구될 수도 있다.
선택적으로, 본 발명의 백신성 조성물은 다른 구성요소를 함유하도록 제형화될 수도 있으며, 예를 들어, 보조제, 안정화제, pH 조정제, 보존제 등을 포함한다. 이러한 구성요소는 당업자들에게 잘 알려져 있다. 적합한 보조제의 예는, 제한 없이, 리포솜, 알룸, 모노포스포릴 지질 A, 및 시토킨, 인터류킨, 케모킨, 리간드, 및 선택적으로 이것들의 조합과 같은 어떤 생물학적 활성 인자를 포함한다. 이 생물학적 활성 인자 중 몇몇은, 예를 들어, 보조제와 같은 플라스미드 또는 바이러스 벡터를 통해 생체 내에서 발현될 수 있다. 예를 들어, 이러한 보조제는 항원을 암호화하는 DNA 백신으로의 프라이밍(priming)에서만 발생되는 면역 반응과 비교하여 항원-특이적 면역 반응을 향상시키기 위해 항원을 암호화하는 프라이밍 DNA 백신과 함께 투여될 수도 있다.
재조합 아데노바이러스는 "면역원성 양", 즉, 원하는 세포를 트랜스펙션하고 면역 반응을 유발하기 위해 선택된 유전자의 충분한 수준의 발현을 제공하기 위해 투여의 경로에서 효과적인 재조합 아데노바이러스의 양으로 투여된다. 보호적 면역력이 제공되며, 재조합 아데노바이러스는 감염 및/또는 재발성 질환을 방지하는데 유용한 백신 조성물인 것으로 간주된다.
대안으로, 또는 이에 더하여, 본 발명의 벡터는 선택된 면역원에 대한 면역 반응을 유발하는 펩티드, 폴리펩티드 또는 단백질을 암호화하는 전이 유전자를 함유할 수도 있다. 본원에서 설명된 재조합 SAdV 벡터는 세포용해성 T 세포 및 벡터에 의해 발현된 삽입된 이종 기원 항원성 단백질에 대한 항체를 유발하는데 매우 효과적인 것으로 예상된다.
예를 들어, 면역원은 다양한 바이러스 과로부터 선택될 수도 있다. 면역 반응이 바람직한 바이러스 과의 예는 리노바이러스(rhinovirus) 속을 포함하고, 감기의 사례 중 약 50%의 원인인 피코르나바이러스(picornavirus) 과; 폴리오바이러스(poliovirus), 콕사키바이러스(coxsackievirus), 에코바이러스(echovirus), 및 A형 간염 바이러스와 같은 인간 엔테로바이러스를 포함하는 엔테로바이러스(enterovirus) 속; 및 주로 비-인간 동물에서, 구제역(foot and mouth disease)의 원인인 아프토바이러스(apthovirus) 속을 포함한다. 바이러스의 피코르나바이러스 과 내에서, 표적 항원은 VP1, VP2, VP3, VP4, 및 VPG를 포함한다. 또 다른 바이러스 과는 바이러스의 노워크(Norwalk) 군을 포함하고, 유행성 위장염(gastroenteritis)의 중요한 원인 인자인 칼시바이러스(calcivirus) 과를 포함한다. 인간 및 비-인간 동물에서 면역 반응을 유발하는 표적화 항원에서 사용에 바람직한 또 다른 바이러스 과는 알파바이러스(alphavirus) 속을 포함하고, 신드비스 바이러스(Sindbis virus), 로스리버 바이러스(RossRiver virus), 및 베네수엘라 (Venezuelan), 동부형 & 서부형 말 뇌막염(encephalitis), 및 루벨라 바이러스(Rubella virus)를 포함하는 루비바이러스(rubivirus)를 포함하는 토가바이러스 과이다. 플라비비리대(flaviviridae) 과는 뎅구열(dengue), 황열병(yellow fever), 일본 뇌염(Japanese encephalitis), 세인트 루이스 뇌막염(St. Louis encephalitis) 및 진드기 매개 뇌염(tick borne encephalitis) 바이러스를 포함한다. 다른 표적 항원은 C형 간염 또는 코로나바이러스(coronavirus) 과로부터 발생될 수도 있으며, 이것은 감염성 기관지염 바이러스(infectious bronchitis virus) (가금류), 돼지 전염성 위장염 바이러스(porcine transmissible gastroenteric virus) (돼지), 돼지 헤마글루니틴화 뇌막염 바이러스(porcine hemagglutinating encephalomyelitis virus) (돼지), 고양이 감염성 복막염 바이러스 (고양이), 고양이 장 코로나바이러스 (고양이), 개 코로나바이러스 (개), 및 인간 호흡기 코로나바이러스와 같이 많은 비-인간 바이러스를 포함하며, 이것은 감기 및/또는 비-A형, B형 또는 C형 간염을 유발할 수도 있다. 코로나바이러스 과 내에서, 표적 항원은 E1 (M 또는 매트릭스 단백질로도 불림), E2 (S 또는 스파이크 단백질로도 불림), E3 (HE 또는 헤마글루틴-엘테로스로도 불림), 당단백질 (모든 코로나바이러스에 존재하지 않음), 또는 N (뉴클레오캡시드)을 포함한다. 또 다른 항원은 라브도바이러스(rhabdovirus) 과에 대하여 표적화될 수도 있으며, 이것은 수포성 바이러스(vesiculovirus) 속 (예를 들어, 수포성 구내염 바이러스(Vesicular Stomatitis Virus)), 및 리사바이러스(lyssavirus) 속 (예를 들어, 광견병(rabies))을 포함한다.
라브도바이러스 과 내에서, 적합한 항원은 G 단백질 또는 N 단백질로부터 유래될 수도 있다. 필로비리대(filoviridae) 과는, 마르부르크(Marburg)와 같은 출혈열 바이러스(출혈열 virus) 및 에볼라 바이러스(Ebola virus)를 포함하며, 항원의 적합한 공급원일 수도 있다. 파라믹소바이러스(paramyxovirus) 과는 파라인플루엔자 바이러스 타입 1, 파라인플루엔자 바이러스 타입 3, 소 파라인플루엔자 바이러스 타입 3, 루불라바이러스(rubulavirus) (귀밑샘염 바이러스(mumps virus)), 파라인플루엔자 바이러스 타입 2, 파라인플루엔자 바이러스 타입 4, 뉴캐슬병 바이러스(Newcastle disease virus) (닭), 우역(rinderpest), 홍역(measles) 및 개 홍역(canine distemper)을 포함하는 모빌리바이러스(morbillivirus), 및 호흡기 세포 융합 바이러스(respiratory syncytial virus)를 포함하는 뉴모바이러스(pneumovirus)를 포함한다. 인플루엔자(인플루엔자) 바이러스는 오르토믹소바이러스(orthomyxovirus) 과 내에서 분류되고 항원 (예를 들어, HA 단백질, N1 단백질)의 적합한 공급원이다. 분야바이러스(bunyavirus) 과는분야바이러스 속 (캘리포니아 뇌염(California encephalitis), 라 크로스(La Crosse)), 플레보바이러스(phlebovirus) (리프트 밸리 열(Rift Valley Fever)), 한타바이러스(hantavirus) (퓨레말라(puremala)는 헤마하긴 열 바이러스(hemahagin fever virus)이다), 나이로바이러스(nairovirus) (나이로비 양 질환(Nairobi sheep disease)) 및 다양한 할당되지 않은 분가바이러스(bungavirus)를 포함한다. 아레나바이러스(arenavirus) 과는 LCM 및 라사 열 바이러스(Lassa fever virus)에 대한 항원의 공급원을 제공한다. 레오바이러스(reovirus) 과는 레오바이러스 속, 로타바이러스(rotavirus) (아이에서 급성 위장염을 유발함), 오르비바이러스(orbivirus), 및 컬티바이러스(cultivirus) (콜로라도 진드기 열(Colorado Tick fever), 르봄보(Lebombo) 인간), 말 뇌염, 블루텅(blue tongue))를 포함한다.
레트로바이러스 과는 고양이 백혈병 바이러스, HTLVI 및 HTLVII, 렌티바이러스(lentivirus) (인간 면역 결핍 바이러스 (human immunodeficiency virus; HIV), 원숭이 면역 결핍 바이러스 (SIV), 고양이 면역 부전 바이러스 (FIV), 말 감염성 빈혈 바이러스(equine infectious anemia virus), 및 스푸마바이러스(spumavirus)를 포함)로서 이러한 인간 및 가축 질환을 포함하는, 종양바이러스(oncovirus) 아과를 포함한다. 항바이러스 중에서, 많은 적합한 항원이 설명되었고 쉽게 선택될 수 있다. 적합한 HIV 및 SIV 항원의 예는, 제한 없이, gag, pol, Vif, Vpx, VPR, Env, Tat, Nef, 및 Rev 단백질, 뿐만 아니라 이것들의 다양한 단편을 포함한다. 예를 들어, Env 단백질의 적합한 단편은, 예를 들어, 길이가 적어도 약 8개의 아미노산인, gp120, gp160, gp41, 또는 이것들의 더 작은 단편과 같은 그것의 서브유닛 중 어떤 것도 포함할 수 있다. 유사하게, tat 단백질의 단편이 선택될 수도 있다 [미국 특허 제5,891,994호 및 미국 특허 제6,193,981호를 참고하면 된다]. 또한 D.H. Barouch et al, J. Virol., 75(5):2462-2467 (March 2001), 및 R.R. Amara, et al, Science, 292:69-74 (6 April 2001)에서 설명된 HIV 및 SIV 단백질을 참고하면 된다. 또 다른 예에서, HIV 및/또는 SIV 면역원성 단백질 또는 펩티드는 융합 단백질 또는 다른 면역원성 분자를 형성하기 위해 사용될 수도 있다. 예를 들어, 2001년 8월 2일에 공개된 제WO 01/54719호, 및1999년 4월 8일에 공개된 제WO 99/16884호에서 설명된 HIV-1 Tat 및/또는 Nef 융합 단백질 및 면역화 요법을 참고하면 된다. 본 발명은 본원에서 설명된 HIV 및/또는 SIV 면역원성 단백질 또는 펩티드에 제한되지 않는다. 게다가, 이 단백질들에 대하여 다양한 변형이 설명되었고 당업자에 의해 쉽게 만들어질 수 있다. 예를 들어, 미국 특허 제5,972,596호에서 설명된 변형된 gag 단백질을 참고하면 된다. 게다가, 어떤 바람직한 HIV 및/또는 SIV 면역원은 단독으로 또는 조합하여 전달될 수도 있다. 이러한 조합은 단일 벡터 또는 다수의 벡터의 발현을 포함할 수도 있다. 선택적으로, 또 다른 조합은 단백질 형태의 면역원 중 하나 이상의 전달과 함께 하나 이상의 발현된 면역원의 전달을 수반할 수도 있다. 이러한 조합은 하기 더 상세히 논의된다.
파포바이러스(papovavirus) 과는 폴리오마바이러스(polyomavirus) 아과 (BKU 및 JCU 바이러스) 및 파필로마바이러스(papillomavirus) 아과 (암 또는 유두종(papilloma)의 악성 진행과 연관됨)를 포함한다. 아데노바이러스 과는 호흡기 질환 및/또는 장염(enteritis)을 유발하는 바이러스 (EX, AD7, ARD, O.B.)를 포함한다. 파르보바이러스(parvovirus) 과는 고양이 파르보바이러스 (고양이 장염), 고양이 판류코페니아바이러스(panleucopeniavirus), 개 파르보바이러스, 및 돼지 파르보바이러스를 포함한다. 헤르페스바이러스(herpesvirus) 과는 단순 바이러스 속 (HSVI, HSVII), 바리셀로바이러스 속 (가성 광견병(pseudorabies), 수두 대상포진(varicella zoster))을 포함하는 알파헤르페스비리내(alphaherpesvirinae) 아과 및 시토메갈로바이러스(cytomegalovirus) 속 (HCMV, 뮤로메갈로바이러스(muromegalovirus))을 포함하는 베타헤르페스비리내(betaherpesvirinae) 아과, 및 림포크립토바이러스(lymphocryptovirus) 속, EBV 속 (버키트 림프종(Burkitts lymphoma)), 감염성 비기관지염(infectious rhinotracheitis), 마렉병(Marek's disease) 바이러스 속, 및 라디노바이러스(rhadinovirus) 속을 포함하는 감마헤르페스비리내(gammaherpesvirinae) 아과를 포함한다. 폭스바이러스 과는 오르토폭스바이러스(orthopoxvirus) 속 (바리올라(Variola) (천연두(Smallpox)) 및 바시니아(Vaccinia) (우두(Cowpox)), 파라폭스바이러스(parapoxvirus) 속, 아비폭스바이러스(avipoxvirus) 속, 카프리폭스바이러스(capripoxvirus) 속, 레포리폭스바이러스(leporipoxvirus) 속, 수이폭스바이러스(suipoxvirus) 속을 포함하는 코르도폭스비리내(chordopoxvirinae) 및 엔토모폭스비리내(entomopoxvirinae) 아과를 포함한다. 헤파드나바이러스(hepadnavirus) 과는 B형 간염 바이러스를 포함한다. 항원의 적합한 공급원일 수도 있는 분류되지 않은 한 바이러스는 간염 델타 바이러스(Hepatitis delta virus)이다. 또 다른 바이러스 공급원은 조류 감염성 F낭병 바이러스(avian infectious bursal disease virus) 및 돼지 생식기 호흡기 증후군 바이러스(porcine respiratory and reproductive syndrome virus)를 포함한다. 알파바이러스(alphavirus) 과는 말 동맥염 바이러스(equine arteritis virus) 및 다양한 뇌염 바이러스를 포함한다.
다른 병원체에 대하여 인간 또는 비-인간 동물을 면역화하는데 유용한 면역원은, 예를 들어, 인간 및 비-인간 척추동물을 감염시키거나, 또는 암 세포 또는 종양 세포의 박테리아, 균류, 기생충 미생물 또는 다세포 기생 생물을 포함한다. 박테리아 병원체의 예는 폐렴 구균(pneumococci); 포도상 구균(staphylococci); 및 연쇄상 구균(streptococci)을 포함하는 병원성 그람-양성 구균을 포함한다. 병원성 그람-음성 구균은 뇌척수막염균(meningococcus); 임균(gonococcus)을 포함한다. 병원성 장 그람-음성 바실루스(bacillus)는 장내 세균(enterobacteriaceae); 슈도모나스(pseudomonas), 아시네토박테리아(acinetobacteria) 및 에이케넬라(eikenella); 멜리오이도시스(melioidosis); 살모넬라(salmonella); 시겔라(shigella); 헤모필루스(haemophilus); 모락셀라(moraxella); 헤모필루스 듀크레이(H. ducreyi) (연성하감(chancroid)을 유발함); 브루셀라(brucella); 프란시셀라 툴라렌시스(Francisella tularensis) (야토병(tularemia)을 유발함); 여시니아(yersinia) (파스퇴렐라(pasteurella)); 스트렙토바실루스 모닐리포르미스(streptobacillus moniliformis) 및 나선균(spirillum)을 포함하고; 그람-양성 바실루스는 리스테리아 모노시토게네스(listeria monocytogenes); 에리시펠로트릭스 루시오파티애(erysipelothrix rhusiopathiae); 코리네박티레움 디프테리아(Corynebacterium diphtheria) (디프테리아); 콜레라; 바실루스 안트라씨스(B. anthracis) (탄저병(anthrax)); 도노바노시스(donovanosis) (서혜부 육아종(granuloma inguinale)); 및 바르토넬라증(bartonellosis)을 포함한다. 병원성 혐기성 박테리아에 의해 유발된 질환은 파상풍(tetanus); 보툴리눔 중독증(botulism); 다른 클로스트리디아(Clostridia); 폐결핵(tuberculosis); 나병(leprosy); 및 다른 미코박테리아(mycobacteria)를 포함한다. 병원성 스피로헤타 병(spirochetal disease)은 매독(syphilis); 트레포네마병(treponematoses): 요오스(yaws), 핀타(pinta) 및 풍토병성 매독(endemic syphilis); 및 렙토스피로시스(leptospirosis)을 포함한다. 고도의 병원체 박테리아 및 병원성 균류에 의해 유발된 다른 감염은 액티노미코시스(actinomycosis); 노카르디오시스(nocardiosis); 크립토코코시스(cryptococcosis), 블라스토미코시스(blastomycosis), 히스토플라스모시스(histoplasmosis) 및 콕시디오이도미코시스(coccidioidomycosis); 칸디디아시스(candidiasis), 아스페르질로시스(aspergillosis), 및 뮤코미코시스(mucormycosis); 스포로트리코시스(sporotrichosis); 파라콕시디오도미코시스(paracoccidiodomycosis), 페트리엘리디오시스(petriellidiosis), 토룰롭소시스(torulopsosis), 균종(mycetoma) 및 크롬-미코시스(chrome-mycosis); 및 더마토피토시스(dermatophytosis)를 포함한다. 리케차 감염(Rickettsial infection)은 발진 티푸스(Typhus fever), 록키산 홍반열(Rocky Mountain spotted fever), Q 열(Q fever), 및 리케차 두창(Rickettsialpox)을 포함한다. 미코플라스마 및 클라미디아 감염증(chlamydial infection)의 예는 폐렴 미코플라스마(mycoplasma pneumoniae); 성병성 림프육아종(lymphogranuloma venereum); 앵무새병(psittacosis); 및 출산전 클라미디아 감염증(perinatal chlamydial infection)을 포함한다. 병원성 진핵생물은 병원성 원생동물 및 연충류(helminthes) 및 이로 인해 생산된 감염을 포함하며, 아메바 감염증(amebiasis); 말라리아(malaria); 리슈만편모충증(leishmaniasis); 트리파노소미아시스(trypanosomiasis); 톡소플라스모시스(toxoplasmosis); 주폐포자충(Pneumocystis carinii); 트리찬스(Trichans); 톡소포자충(Toxoplasma gondii); 바베시아증(babesiosis); 지아디아증(giardiasis); 선모충증(trichinosis); 필라리아증(filariasis); 주혈흡충증(schistosomiasis); 선충(nematodes); 흡충류(trematodes) 또는 흡충(flukes); 및 촌충(cestode) (촌충류(tapeworm)) 감염을 포함한다.
이 유기체 및/또는 이로 인해 생산된 독소 중 다수는 질병 관리 본부 [(Centers for Disease Control; CDC), 보건복지부, 미국]에 의해, 생물학적 공격에 사용될 가능성을 가진 약제로 확인되었다. 예를 들어, 이 생물학적 약제 중 일부는 모두 현재 범주 A 약제로서 분류되는, 탄저균(Bacillus anthracis) (탄저병), 클로스트리듐 보툴리눔(Clostridium botulinum) 및 그것의 독소(보툴리눔 중독증), 페스트균(Yersinia pestis) (흑사병(plague)), 대두창(variola major) (천연두), 프란시셀라 툴라렌시스 (야토병), 및 바이러스 출혈열 [필로바이러스(filovirus) (예를 들어, 에볼라, 마르부르크), 및 아레나바이러스 (예를 들어, 라사, 마추포(Machupo))]; 모두 현재 범주 B 약제로서 분류되는, 콕시엘라 부르네티(Coxiella burnetii) (Q 열); 부르셀라 종(Brucella species) (브루셀라병(brucellosis)), 부르크홀데리아 말레이(Burkholderia mallei) (마비저(glanders)), 부르크홀데리아 슈도말레이(Burkholderia pseudomallei) (멜로이도시스(meloidosis)), 피마자(Ricinus communis) 및 그것의 독소 (리신 독소), 클로스트리듐 퍼프링겐스(Clostridium perfringens) 및 그것의 독소 (엡실론 독소), 스타필로코쿠스 종(Staphylococcus species) 및 그것들의 독소 (장내독소 B), 앵무새병 클라미디아(Chlamydia psittaci) (앵무새병), 수상 안전 위협 (예를 들어, 비브리오 콜레래(Vibrio cholerae), 크리토스포리듐 파르붐(Crytosporidium parvum), 발진 티푸스 (리카차 포와제키(Rickettsia powazekii)), 및 바이러스성 뇌염(알파바이러스, 예를 들어, 베네수엘라 말 뇌염; 동부형 말 뇌염; 서부형 말 뇌염) 및 모두 현재 범주 C 약제로서 분류되는, 니판 바이러스(Nipan virus)및 한타바이러스를 포함한다. 게다가, 그렇게 분류되거나 다르게 분류되는, 다른 유기체들은 미래에 이러한 목적을 위해 확인되고 및/또는 사용될 수도 있다. 바이러스 벡터 및 본원에서 설명된 다른 구조는 이 유기체, 바이러스, 그것들의 독소 또는 다른 부산물로부터 항원을 전달하는데 유용하며, 이것은 이 생물학적 약제로 감염 또는 다른 해로운 반응을 방지하고 및/또는 치료한다는 것이 쉽게 이해될 것이다.
T 세포의 가변 영역에 대한 항원을 전달하기 위한 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 벡터의 투여는 상기 T 세포를 제거하기 위해 CTL을 포함하는 면역 반응을 유도하는 것으로 예상된다. RA에서, 질환에 수반되는 TCR의 여러 특이적 가변 영역이 특성화되었다. 이 TCR들은 V-3, V-14, V-17 및 Vα-17을 포함한다. 따라서, 이 폴리펩티드들 중 적어도 하나를 암호화하는 핵산 서열의 전달은 RA에 수반된 T 세포를 표적화하는 면역 반응을 유도할 것이다. MS에서, 질환에 수반되는 TCR의 여러 특이적 가변 영역이 특성화되었다. 이 TCR들은 V-7 및 Vα-10을 포함한다. 따라서, 이 폴리펩티드들 중 적어도 하나를 암호화하는 핵산 서열의 전달은 MS에 수반되는 T 세포를 표적화하는 면역 반응을 유도할 것이다. 경피증에서, 질환에 수반되는 TCR의 여러 특이적 가변 영역이 특성화되었다. 이 TCR들은 V-6, V-8, V-14 및 Vα-16, Vα-3C, Vα-7, Vα-14, Vα-15, Vα-16, Vα-28 및 Vα-12를 포함한다. 따라서, 이 폴리펩티드들 중 적어도 하나를 암호화하는 재조합 원숭이 아데노바이러스의 전달은 경피증에 수반된 T 세포를 표적화하는 면역 반응을 유도할 것이다.
C. Ad-매개된 전달 방법
선택된 유전자의 치료적 수준, 또는 면역력의 수준은 촉진제에 대한 필요를, 있으면, 결정하기 위해 관찰될 수 있다. 혈청에서, CD8+ T 세포 반응, 또는 선택적으로, 항체 역가의 평가 후, 선택적 촉진제 면역화가 요구될 수도 있다. 선택적으로, 재조합 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 벡터는 단일 투여로 또는 다양한 조합 요법으로, 예를 들어, 다른 활성 성분을 수반하는 치료의 요법 또는 경로와 결합하여 또는 프라임(prime)-촉진 요법에 전달될 수도 있다. 이러한 다양한 요법은 업계에 설명되어 있고 쉽계 선택될 수도 있다.
예를 들어, 프라임-촉진 요법은 제2, 촉진제, 투여에 대한 면역 시스템을 전통적인 항원, 예를 들어, 이러한 항원을 암호화하는 서열을 가지고 있는 단백질 또는 재조합 바이러스에 프라이밍하기 위해 DNA (예를 들어, 플라스미드) 기반 벡터의 투여를 수반할 수도 있다. 예를 들어, 2000년 3월 2일에 공개되고, 참고로 포함되는 제WO 00/11140호를 참고하면 된다. 대안으로, 면역화 요법은 항원, 또는 단백질을 가지고 있는 벡터 (바이러스 또는 DNA-기반)에 대한 면역 반응을 촉진하기 위해 재조합 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 벡터의 투여를 수반할 수도 있다. 또 다른 대안에서, 면역화 요법은 단백질의 투여 후 이어서 항원을 암호화하는 벡터로의 촉진을 수반한다.
한 구체예에서, 상기 항원을 가지고 있는 플라스미드 DNA 벡터를 전달한 후 이어서, 재조합 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 벡터로 촉진함으로써 선택된 항원에 대한 면역 반응을 프라이밍하고 촉진하는 방법이 설명된다. 한 구체예에서, 프라임-촉진 요법은 프라임 및/또는 촉진 비히클(vehicle)로부터 다중 단백질의 발현을 수반한다. 예를 들어, R.R. Amara, Science, 292:69-74 (2001년 4월 6일)를 참고하면 되고, HIV 및 SIV에 대한 면역 반응을 발생시키는데 유용한 단백질 서브 유닛의 발현에 대한 다중 단백질 요법을 설명한다. 예를 들어, DNA 프라임은 단일 전사물로부터 Gag, Pol, Vif, VPX 및 Vpr 및 Env, Tat, 및 Rev를 전달할 수도 있다. 대안으로, SIV Gag, Pol 및 HIV-1 Env는 재조합 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 아데노바이러스 구조에서 전달된다. 또 다른 요법은 제WO 99/16884호 및 제WO 01/54719호에서 설명된다.
하지만, 프라임-촉진 요법은 HIV에 대한 면역화 또는 이 항원들의 전달에 제한되지 않는다. 예를 들어, 프라이밍(priming)은 먼저 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 벡터를 전달한 후 이어서 두 번째로 Ad 벡터, 또는 단백질 형태의 항원 그 자체를 함유하는 조성물로 촉진하는 단계를 수반할 수도 있다. 한 예에서, 프라임-촉진 요법은 바이러스, 박테리아 또는 항원이 유래되는 다른 유기체에 대한 보호 면역 반응을 제공할 수 있다. 또 다른 구체예에서, 프라임-촉진 요법은 치료가 투여되는 상태의 존재의 검출을 위해 통상적인 검정을 사용하여 측정될 수 있는 치료적 효과를 제공한다.
프라이밍 조성물은 용량 의존적 방식으로 신체의 다양한 부위에 투여될 수도 있는데, 이것은 원하는 면역 반응이 표적화되는 항원에 의존적이다. 주사(들)의 또는 약학적 담체에 대한 양 또는 위치는 제한되지 않는다. 오히려, 요법은 프라이밍 단계 및/또는 촉진 단계를 수반할 수도 있으며, 이것들 각각은 단일 용량 또는 매 시간, 매일, 매주 또는 매달, 또는 매년 투여되는 투약량을 포함한다. 예로서, 포유동물은 담체에서 약 10 μg 내지 약 50 μg의 플라스미드를 함유하는 일회 또는 이회 용량을 받을 수도 있다. DNA 조성물의 바람직한 양은 DNA 벡터의 약 1 μg 내지 약 10,000 μg의 범위에 있다. 투약량은 대상 체중의 kg 당 약 1 μg 내지 1000 μg DNA로 다를 수도 있다. 전달의 양 또는 부위는 바람직하게 포유동물의 동일성 및 상태에 기초하여 선택된다.
항원의 포유동물로의 전달에 적합한 벡터의 투약 단위가 본원에서 설명된다. 벡터는 등장성 식염수; 등장성 염 용액 또는 다른 이러한 투여 업자에게 분명해지는 제형과 같이 약학적으로 또는 생리학적으로 허용 가능한 담체에서 현탁되거나 용해됨으로써 투여용으로 제조된다. 적절한 담체는 당업자에게 명백해질 것이며 투여의 경로에 크게 의존적일 것이다. 본원에서 설명된 조성물은 상기 설명된 경로에 따라, 생분해성 생체 적합성 폴리머를 사용하는 지속적인 방출 제형으로, 미셀(micelle), 겔 및 리포솜을 사용하는 온-사이트(on-site) 전달에 의해 포유동물에 투여될 수도 있다. 선택적으로, 프라이밍 단계는 또한, 본원에서 정의된 바와 같이, 프라이밍 조성물, 적합한 양의 보조제를 투여하는 단계를 포함한다.
바람직하게, 촉진 조성물은 프라이밍 조성물을 포유동물 대상에게 투여한 후 약 2 내지 약 27 주에 투여된다. 촉진 조성물의 투여는 프라이밍 DNA 백신에 의해 투여된 것과 같은 항원을 함유하거나 이것을 전달할 수 있는 촉진 조성물의 유효량을 사용하여 성취된다. 촉진 조성물은 같은 바이러스 공급원 (예를 들어, 본 발명의 아데노바이러스 서열) 또는 또 다른 공급원으로부터 유래된 재조합 바이러스 벡터로 구성될 수도 있다. 대안으로, "촉진 조성물"은 프라이밍 DNA 백신에서 암호화된 것과 같지만, 단백질 또는 펩티드의 형태의 항원을 함유하는 조성물일 수 있으며, 이 조성물은 숙주에서 면역 반응을 유발한다. 또 다른 구체예에서, 촉진 조성물은 포유동물 세포에서 발현을 지시하는 조절 서열의 제어 하에 항원을 암호화하는 DNA 서열, 예를 들어, 잘 알려진 박테리아 또는 바이러스 벡터와 같은 벡터를 함유한다. 촉진 조성물의 주요 요구사항은 조성물의 항원이 프라이밍 조성물에 의해 암호화된 것과 같은 항원이거나, 또는 교차-반응성 항원이라는 점이다.
또 다른 구체예에서, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 벡터는 또한 다양한 다른 면역화 및 치료적 요법에서 사용에 적합하다. 이러한 요법은 다른 혈청형 캡시드의 Ad 벡터와 동시에 또는 순차적으로 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 벡터의 전달을 수반할 수도 있으며, 이 요법에서 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 벡터가 비-Ad 벡터와 동시에 또는 순차적에 전달되고, 이 요법에서 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 벡터가 단백질, 펩티드, 및/또는 다른 생물학적으로 유용한 치료적 또는 면역원성 화합물과 동시에 또는 순차적에 전달된다. 이러한 사용은 당업자에게 쉽게 분명해질 것이다.
또 다른 구체예에서, 본 발명은 아데노바이러스 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 캡시드를 대상에 전달함으로써 면역 조절 효과 반응을 유발하기 위해, 또는 또 다른 활성제에 대한 세포 독성 T 세포 반응을 향상시키거나 보조하기 위해 이 바이러스들의 캡시드 (선택적으로 온전한 또는 재조합 바이러스 입자 또는 빈 캡시드가 사용됨)의 사용을 제공한다. SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 캡시드는 이것에 대한 면역 반응을 향상시키기 위해 단독으로 또는 활성제와의 조합 요법에 전달될 수 있다. 유리하게는, 숙주를 부분군 E 아데노바이러스로 감염시키지 않고 원하는 효과가 달성될 수 있다. 또 다른 양태에서, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 캡시드를 대상체에 전달하는 단계를 포함하는, 이것이 필요한 대상에서 인터페론 알파 생산을 유발하는 방법이 제공된다. 또 다른 양태에서, 배양물에서 하나 이상의 시토킨 (예를 들어, IFN-α)/케모킨을 생산하는 방법이 제공된다. 이 방법은 다른 것들 중에서, 알파 인터페론을 포함하는 시토킨/케모킨을 생산하는데 적합한 조건 하에 수지상 세포 및 본원에서 설명된 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 캡시드를 함유하는 배양물을 배양하는 단계를 수반한다.
이렇게 생산된 시토킨은 다양한 적용에서 유용하다. 예를 들어, IFNα의 경우에서, 본원에서 설명된 생산이 특히 바람직한데, 그것이 상업적으로 이용 가능한 재조합에 의해 생산된 IFNα보다 유리함을 제공할 것이라고 생각되기 때문이며, 이것은 박테리아에서 생산된 IFNα의 단 하나 또는 두 개의 서브타입을 함유한다. 반대로, 방법은 다수의 서브타입의 천연 인간 IFNα를 생산하는 것으로 예측되는데, 이것은 광범위한 작용을 일으킬 것으로 예상된다. 각 서브타입은 특이적인 생물학적 활성을 이용하는 것으로 생각된다. 게다가, 본원에서 제공된 방법에 의해 생산된 천연 인터페론이 환자의 자연스럽게 생산된 인터페론과 면역학적으로 구분할 수 없으며, 이로 인해 보통 재조합에 의해 생산된 인터페론에 대한 중화 항체의 형성에 의해 유발되는 대상의 면역 시스템에 의해 거부당한 약물의 위험을 감소시키는 것으로 예측된다.
부분군 E 아데노바이러스에 의해 생산된 다른 시토킨은 인터류킨 (IL)-6, IL-8, IP-10, 마크로파지 염증 단백직-1 알파 (MIP-1α), RANTES, 및 종양 괴사 인자 알파를 포함한다. 배양물로부터 이 시토킨/케모킨을 정제하는 방법 및 이 시토킨/케모킨의 치료적 또는 보조적 사용이 문헌에서 설명되었다. 게다가, 상업적으로 이용 가능한 컬럼 또는 키트가 본 발명에 따라 제조된 시토킨/케모킨의 정제에 사용될 수도 있다. 본 발명을 사용하여 생산된 시토킨/케모킨은 다양한 징후에서 사용을 위해 제형화될 수도 있다.
예를 들어, 본원에서 설명된 시토킨은 인터페론 알파 (IFNα), 종양 괴사 인자 알파 (TNFα), IP-10 (인터페론 감마 유발성 단백질), 인터류킨-6 (IL-6), 및 IL-8을 포함한다. IFNα는 인플루엔자(influenza), 간염 (예를 들어, B형 간염 및 C형 간염), 및 다양한 신생물, 예를 들어, 신장 (신세포 암(renal cell carcinoma)), 흑색종(melanoma), 악성 종양, 다발성 골수종(multiple myeloma), 칼시노이드 종양(carcinoid tumor), 림프종 및 백혈병 (예를 들어, 만성 골수성 백혈병(chronic myelogenous leukemia) 및 모양 세포성 백혈병(hairy cell leukemia))의 치료에 유용한 것으로 설명되었다. 본원에서 설명된 바와 같이 생산된 IFNα 서브타입의 혼합물은 알려진 기술을 사용하여 정제될 수 있다. 예를 들어, 단클론성 항체의 사용 및 컬럼 정제를 설명하는 제WO 2006/085092호를 참고하면 된다. 다른 기술이 문헌에서 설명되었다. 본원에서 설명된 바와 같이 생산된 IFNα는 알려져 있는 방법을 사용하여 정제될 수 있다. 예를 들어, 미국 특허 번호 제4,680,260호, 미국 특허 번호 제4,732,683호, 및 G. Allen, Biochem J., 207:397-408 (1982)를 참고하면 된다. TNFα는, 예를 들어, 건선 및 류머티스성 관절염을 포함하는 자가 면역 장애의 치료에 유용한 것으로 설명되었다. IP-10, 인터페론 감마 유발성 단백질은 혈관 형성(angiogenesis)의 강력한 억제자로서 및 강력한 흉선-의존적 항-종양 효과를 갖기 위해 사용될 수 있다.
시토킨을 생산하는데 적합한 조건 하에서 수지상 세포 및 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 캡시드를 함유하는 배양물을 배양함으로써 IFNα를 생산하는 방법이 제공된다. 한 구체예에서, 혈액을 건강한 기증자 (바람직하게 인간)로부터 뽑아내고 말초 혈액 백혈구 (PBL) 또는 말초 혈액 단핵 세포 (PBMC)는 알려진 기술을 사용하여 제조된다. 한 구체예에서, PBL은 본 발명의 방법에 따라 시토킨-생산 세포로서 사용된다. 또 다른 구체예에서, PBMC는 시토킨-생산 세포로서 사용된다. 또 다른 구체예에서, 형질세포양(plasmacytoid) 수지상 세포는 알려진 기술을 사용하여, 예를 들어, Miltenyi Biotec GmbH (Germany)의 상업적으로 이용 가능한 키트인 "인간 형질세포양 수지상 세포 분리 키트"를 사용하여 PBL 또는 PBMC로부터 분리된다. 선택된 세포는 적절한 배지 및 아데노바이러스 부분군 E 캡시드 단백질과 현탁하여 배양된다. 적절한 배지는 당업자에 의해 쉽게 결정될 수 있다. 하지만, 한 구체에에서, 배지는 RPMI-1640 배지이다. 대안으로, 다른 배지가 쉽게 선택될 수도 있다. 세포는 적합한 용기, 예를 들어, 미세역가 웰, 플라스크, 또는 더 큰 용기에서 배양될 수도 있다. 한 구체예에서, 세포의 농도는 약 100만 개 세포/mL 배양 배지이다. 하지만, 다른 적합한 세포 농도는 당업자에 의해 쉽게 결정될 수도 있다. 본 발명은 프라이머로서 인터페론의 사용을 필요로 하지 않는다. 하지만, 원하면, 배지는 세포 성장을 작그하기 위해 적합한 시토킨, IL-3을 포함할 수도 있다. 한 적합한 농도는 약 20 ng/mL이다. 하지만, 다른 농도가 사용될 수도 있다. 한 구체예에서, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 캡시드 단백질은 세포를 함유하는 배지로 도입된다. 아데노바이러스 캡시드 단백질은 본원에서 설명된 형태 (예를 들어, 빈 캡시드 입자를 포함하는 바이러스 입자, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 캡시드를 갖는 바이러스 벡터, 등) 중 어떤 것으로도 배양물에 전달될 수 있다. 전형적으로, 캡시드 단백질은 적합한 담체, 예를 들어, 배양 배지, 식염수,등에 현탁될 것이다. 적합하게, SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 캡시드는 세포 당 약 100 내지 100,000 아데노바이러스 부분군 E 입자의 양으로 배양물에 추가된다. 그 다음에 혼합물은, 예를 들어, 약 28℃ 내지 약 40℃의 범위, 약 35℃ 내지 약 37℃의 범위, 또는 약 37℃에서 배양된다. 전형적으로, 대략 12 내지 96시간, 또는 약 48시간 후에, 세포는 스핀 다운(spin down)되고 상층액이 수거된다. 적합하게, 이것은 세포 용해를 막고, 이로 인해 상층액 중의 세포 데브리(debris)의 존재를 감소시키거나 제거하는 조건 하에서 수행된다. 원심분리는 세포로부터 시토킨의 분리를 허용하고, 이로 인해 대충 분리된 시토킨을 제공한다. 사이징(sizing) 컬럼, 및 다른 알려진 컬럼 및 방법이 아데노바이러스 및 아데노바이러스 캡시드, 등으로부터 시토킨의 추가의 정제에 이용 가능하다. 이렇게 정제된 이 시토킨은 다양한 적용에서 제형화 및 사용에 이용 가능하다.
한 구체예에서, 빈 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 입자 (즉, 어떤 아데노바이러스 또는 전이 유전자 생성물도 발현하는, 그 안에 포장된 DNA를 갖지 않는 아데노바이러스 캡시드)가 세포에 전달될 수도 있다. 또 다른 구체예에서, 비-감염성 야생형 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 입자 또는 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 캡시드 (입자)에서 포장된 재조합 아데노바이러스 벡터가 사용될 수도 있다. 이러한 바이러스 입자를 비활성화시키는 적합한 기술이 업계에 알려져 있고, 제한 없이, 예를 들어, UV 조사 (발현을 방해하는 게놈 DNA에 효과적으로 교차결합함)를 포함할 수도 있다.
다음 예는 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337의 클로닝 및 예시적 재조합 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 벡터의 구성을 설명한다. 이 실시예는 단지 예시적이지만, 본 발명의 범위를 제한하지는 않는다.
실시예 1 - 원숭이 아데노바이러스의 분리
스툴(stool) 샘플을 미국 루이지애나 뉴 이베리아 더블유, 어드미럴 도일 드라이브 4401의 루이지애나 대학 뉴 이베리아 연구 센터(University of Louisiana New Iberia Research Center)의 침팬지 콜로니로부터 얻었다. 스툴 현탁액의 여과된 상층액을 인간 세포주 A549의 배양물에 접종하였다. 배양의 약 1 내지 2주 후에, 시각적인 세포 변성 효과 (CPE)는 다수의 접종물이 있는 세포 배양물에서 명백하였다. 이 기술에 의해 분리된 바이러스를 염화 세슘 구배 밴딩(banding)의 표준 아데노바이러스 정제 방법을 사용하여 A549 세포를 사용하는 대규모 조제물로 증폭시켰다. 정제된 아데노바이러스의 DNA를 분리하여 독일 힐덴의 Qiagen Genomics services에 의해 완전히 시퀀싱하였다(sequenced). 완전한 게놈 서열의 분석은 분리된 바이러스가 이전에 보고되지 않은 새로운 서열을 가진다는 것을 나타냈다.
바이러스 DNA 서열의 계통 발생 분석에 기초하여, 원숭이 아데노바이러스 A1302 (SAdV-A1302), SAdV-A1320, SAdV-A1331, 및 SAdV-A1337로 지정된 아데노바이러스를 부분군(종) E와 같은 부분군에 있는 것으로 결정하였다. 바이러스 증폭에 대한 평균수득율은 다음과 같았다: A1302 (1.45 x 1013), SAdV-A1320 (1.35 x 1013), SAdV-A1331 (5.62 x 1013), 및 SAdV-A1337 (6.54 x 1013).
실시예 2 - 벡터 구성
SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 (부분군 E)을 사용하는 E1 결실된 벡터를 일반적으로 설명된 바와 같이 제조할 수도 있다.
SwaI에 의해 플랭킹된 (flanked) SmaI, ClaI, XbaI, SpeI, EcoRV 부위를 함유하는 결합자를 EcoRI 및 NdeI으로 잘린 pBR322로 클로닝한다. 바이러스 DNA를 XbaI로 분해하고 6 kb 단편 (왼쪽 및 오른쪽 끝)을 겔 정제하여 SmaI 및 XbaI로 분해된 pSR5로 결찰하였다. 12개의 미니프렙(miniprep)을 SmaI로 진단하고 예상된 단편 크기에 대하여 평가한다. 미니프렙을 시퀀싱하여 바이러스 DNA 끝의 온전성을 점검한다. 얻어진 서열을 사용하여 왼쪽 끝 Qiagen 서열을 수정하였고 또한 올바른 오른쪽 ITR 서열을 추정하였다.
플라스미드를 SnaBI + NdeI으로 분해하고 NdeI 부위를 클레노브(Klonow)로 메웠다. pBleuSK I-PI의 EcoRV 단편을 결찰한다. 대안으로 플라스미드를 SnaBI 및 NdeI로 분해하고 CeuI 및 PI-SceI에 대한 인식 부위를 함유하는 이중 가닥 올리고뉴클레오티드를 결실된 E1 암호화 여역을 대신해서 결찰한다. 미니프렙을 PstI을 사용하여 진단한다. 결과의 플라스미드를 XbaI + EcoRV로 분해한다. SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337의 오른쪽 끝 (XbaI 분해) 단편을 결찰한다. 미니프렙을 ApaLI을 사용하여 진단한다. 그 다음에 결과의 플라스미드를 XbaI + EcoRV로 분해한다. SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 DNA의 단편을 결찰하고 미니프렙을 MfeI을 사용하여 진단한다. 그 다음에 293 세포를 인산 칼슘 또는 제조사의 프로토콜에 따라 리포펙타민(lipofectamine) 방법을 사용하여 트랜스펙션한다.
실시예 3 - 교차-중화 항체의 평가
A. 야생형 SAdV-A1302, SAdV-A1320, SAdV-A1331, 및 SAdV-A1337을 직접적인 면역 형광법에 의해 관찰된 감염 억제 중화 항체 검정을 사용하여 인간 아데노바이러스 5 (아종 C) 및 침팬지 아데노바이러스 7 (SAdV-24), 및 인간 풀링된(pooled) IgG와 비교하여 교차-중화 활성에 대하여 평가하였다. 인간 풀링된 IgG [Hu Pooled IgG]를 상업적으로 구입하였고 면역 손상 환자에서 투여에 대하여 인증되는데, 일반적인 인간 집단이 노출되는 많은 항원에 대한 항체를 함유하기 때문이다. 인간 풀링된 IgG에 대하여 원숭이 아데노바이러스에 대한 중화 항체의 존재 또는 부재는 일반적인 집단에서 이 아데노바이러스에 대한 항체의 출현율의 반영이다.
다음과 같이 검정을 수행한다. 이전에 HAdV-5 또는 SAdV-24가 주사된 토끼로부터 얻어진 혈청 샘플을 56℃에서 35분 동안 열 불활성화한다. 야생형 아데노바이러스 (10개의 입자/웰)를 혈청이 없는 둘베코 변형 이글 배지 (Dulbecco's modified Eagle's medium; DMEM)에서 희석하고 37℃에서 1시간 동안 DMEM에서 열-불활성화된 혈청 샘플의 2배 단계 희석액과 함께 배양한다. 그 후, 혈청-아데노바이러스 혼합물을 105 단층 A549 세포로 웰의 슬라이드에 추가한다. 1시간 후, 각 웰의 세포에 100 μl의 20% 소 태아 혈청 (FBS)-DMEM을 보충하고 5% CO2에서 37℃에서 22시간 동안 배양한다. 그 다음에, 세포를 PBS로 두 번 헹구고 파라포름알데히드에서 고정 (4%, 30분) 및 0.2% Triton에서 투과화 (4℃, 20분) 후 DAPI 및 HAdV-5에 대하여 발생한 염소, FITC 표지된, 광범위한 교차 반응성 항체 (Virostat)로 염색한다. 감염의 수준을 현미경 하에서 FITC 양성 세포의 수를 계수함으로써 결정한다. NAB 역가는 나이브 혈청 대조군과 비교하여, 50% 이상 만큼 아데노바이러스 감염을 나타내는 최고 혈청 희석 배수로서 보고된다. <1/20의 역가 값이 나타나는 경우, 중화 항체 농도는 검출의 한계, 즉, 1/20보다 낮다.
B. 야생형 SAdV-A1302, SAdV-A1320, SAdV-A1331, 및 SAdV-A1337을 인간 아데노바이러스 5 (HAdV-5; 아종 C)와 비교하여 교차-중화 활성에 대하여 평가하였다. 결과는 하기 표 3에서 나타난다. 인간 샘플의 집단 (n=20) 중 대략 15% 미만이 HAdV-5에 대하여 대략 40%에 비해 확인된 아데노바이러스에 대하여 200이상의 중화 항체 역가 (NAb 역가)를 갖는다.
인간 샘플
(n = 20) Nab 역가
야생형
아데노바이러스		 IVIG Nab 역가 (10mlg/ml) 중간값 평균
A1302 80 80 124
A1320 20 20 26
A1331 40 20 20
A1337 20 30 47
HAdV-5 640 640 1589
실시예 4 - 분자적 클론 구성
A. SAdV-A1302
E1 결실된 SAdV-A1302 클론을 pS 7 플라스미드 (SEQ ID NO: 202)를 SnaBI + Nde로 분해함으로써 제조하고 끝에 CIP를 처리하고, 플라스미드로 통합을 위해 ~3021 bp 왼쪽 끝 (Start-NdeI) 단편을 생산하도록 야생형 SAdV-A1302 서열 (SEQ ID NO: 1)에 NdeI를 처리한다. 결과의 플라스미드 (pS240-1302)를 SnaBI + Nde로 분해하고 끝을 클레노브로 메웠고 CIP를 처리한다. pBleuSK I-PI 플라스미드 (SEQ ID NO: 203 - I-CeuI 및 PI-SceI에 대한 잠복 부위)를 플라스미드 pS241-A1302를 형성하도록 폴리머라제 I와 함께 SmaI 및 HindIII로 분해한다. 그 다음에 pS241-A1302에 Pac/exonuc-inact/Nde/CIP를 처리하고, 야생형 SAdV-A1302 서열 (SEQ ID NO: 1)의 ~7071 bp 오른쪽 끝 (Nde-끝) 단편을 그 안에 클로닝하여 pS242_A1302 플라스미드를 발생시킨다. 그 다음에 pS242_A1302 플라스미드를 NdeI로 분해하고 끝에 CIP를 처리하고 야생형 SAdV-A1302 서열 (SEQ ID NO: 1)의 ~26 kbp 단편을 그 안에 클로닝하여 pS243-A1302 플라스미드를 발생시킨다.
그 다음에 적합한 전이 유전자 발현 카세트를 pS243-A1302로 도입한다. 전이 유전자는, 예를 들어, eGFP, 인플루엔자 A 핵단백질, 또는 pBleuSK I-PI 플라스미드 단편의 I-CeuI 및 PI-SceI 부위를 통해 HIV-gag (예를 들어, pSh-HIV-short-gag (SEQ ID NO: 198)의 것)와 같은 리포터가 될 수도 있다. HIV gag short 서열을 I-CeuI 및 PI-SceI 부위를 통해 p2311 (SEQ ID NO: 391) 또는 p0621 (SEQ ID NO: 394))의 메가뉴클레아제 카세트로부터 얻을 수도 있다. 본원에서 설명되고 업계에 알려져 있는 추가적인 전이 유전자가 이 실시예 및 당업계의 기술과 일치하게 사용될 수도 있고 본원에서 고려된다.
HIV-gag 전이 유전자를 함유하는 제안된 E1 결실된 SAdV-A1302 클론을 SEQ ID NO: 104에서 확인하였다.
B. SAdV-A1320
E1 결실된 SAdV-A1320 클론 (SEQ ID NO: 206), p2870을 다음과 같이 제조하였고, 모든 단계를 표준 분자 생물학적 방법을 사용하여 실행하였다. 5' ITR에서 NheI 부위로의 야생형 A1320 서열 (SEQ ID NO: 25)의 5' (왼쪽 끝)을 Sma/NheI 부위에서 셔틀 플라스미드 pSRJ (SEQ ID NO: 202)로 삽입하였다. SEQ ID NO: 25 (E1a, E1b 19k, 및 E1b의 ~75%에 대한 암호화 서열)의 NdeI/EcoRV 단편을 메가뉴클레아제 클로닝 카세트 (EcoRV/EcoRV 제한 부위)로 대체하였다. 그 다음에 NheI 부위에서 3' ITR로의 야생형 A1320 서열 (SEQ ID NO: 25)의 3' (오른쪽 끝)을 셔틀 플라스미드 (NheI/EcoRV 단편를 대체함)로 삽입하였다. 그 다음에 아데노바이러스 게놈 (SEQ ID NO: 25)의 나머지 중간 섹션 (NheI/NheI)을 NheI 부위를 통해 셔틀 플라스미드에 추가하였다.
HIVgag(short) 서열을 가진 E1 결실된 SAdV-A1320 클론을 또한 제조하였다 (SEQ ID NO: 246; p2876). E1 결실된 SAdV-A1320 클론 (SEQ ID NO: 206), p2870을 I-CeuI 및 PI-SceI로 분해하였고, 제거된 단편을 I-CeuI 및 PI-SceI 부위를 통해 p0621 (SEQ ID NO: 394)의 메가뉴클레아제 카세트로 대체하였다.
C. SAdV-A1331
E1 결실된 SAdV-A1331 클론을 pSR5 플라스미드 (SEQ ID NO: 201)를 SmaI + SpeI로 분해함으로써 제조하고 끝에 CIP를 처리하고, 여러 단편을 생산하기 위해 야생형 SAdV-A1331 서열 (SEQ ID NO: 50)에 SpeI를 처리한다. ~10,629 bp 단편은 플라스미드에 통합된다. 결과의 플라스미드 (pS230-1331)를 BsiWI + NdeI 또는 SnaBI + NdeI으로 분해하고, ICeuPIScel 메가뉴클레아제 카세트(들) (SEQ ID NO: 205)를 SnaIB (BsiWI) + NdeI 부위를 통해 그 안에 클로닝한다. 그 다음에 결과의 플라스미드 (pS231-1331)를 EcoRV + SpeI로 분해하고, SpeI로 분해된 야생형 SAdV-A1331 서열 (SEQ ID NO: 50)의 ~1301 bp 단편을 그 안에 클로닝하며 pS232-Al 331 플라스미드를 발생시킨다. 그 다음에 pS232-A1331을 SpeI로 분해하고 CIP를 처리하고, SpeI로 분해된 야생형 SAdV-A1331 서열 (SEQ ID NO: 50)의 ~24,718 bp 단편을 그 안에 클로닝하며 pS233-A1331 플라스미드를 발생시킨다.
그 다음에 적합한 전이 유전자 발현 카세트를 pS233-A1331 플라스미드로 도입한다. 전이 유전자는, 예를 들어, 메가뉴클레아제 카세트의 I-CeuI 및 PI-SceI 부위를 통해 eGFP, 인플루엔자 A 핵단백질, 또는 HIV-gag (예를 들어, pSh-HIV-short-gag (SEQ ID NO: 198)의 것)와 같은 리포터가 될 수도 있다. HIV gag short 서열을 또한 I-CeuI 및 PI-SceI 부위를 통해 p2311 (SEQ ID NO: 391) 또는 p0621 (SEQ ID NO: 394)의 메가뉴클레아제 카세트로부터 얻을 수도 있다. 본원에서 설명되고 업계에 알려져 있는 추가적인 전이 유전자가 이 실시예 및 당업계의 기술과 일치하게 사용될 수도 있고 본원에서 고려된다.
HIV-gag 전이 유전자를 함유하는 제안된 E1 결실된 SAdV-A1331 클론을 SEQ ID NO: 151에서 확인하였다.
D. SAdV-A1337
E1 결실된 SAdV-A1337 클론 (SEQ ID NO: 287), p2875을 다음과 같이 제조하였고, 모든 단계를 표준 분자 생물학적 방법을 사용하여 실행하였다. 5' ITR에서 NdeI 부위로의 야생형 A1337 서열 (SEQ ID NO: 77)의 5' (왼쪽 끝)을 SnaBI/NdeI 부위에서 셔틀 플라스미드 pSR7 (SEQ ID NO: 202)로 삽입하였다. SEQ ID NO: 77 (E1a, E1b 19k, 및 E1b의 ~50%에 대한 암호화 서열)의 SnaBI/SmaI 단편을 메가뉴클레아제 클로닝 카세트 (EcoRV/EcoRV 제한 부위)로 대체하였고 E1b로부터 400bp를 더 결실하기 위해 PI-Scel/NdeI 단편을 PI-Scel/NdeI 결합자로 대체하였다. 그 다음에 NdeI 부위에서 3' ITR로의 야생형 A1337 서열 (SEQ ID NO: 77)의 3' (오른쪽 끝)을 셔틀 플라스미드 (NdeI/EcoRV 단편을 대체함)로 삽입하였다. 그 다음에 아데노바이러스 게놈 (SEQ ID NO: 77)의 나머지 중간 섹션 (NdeI/NdeI)을 NdeI 부위를 통해 셔틀 플라스미드에 추가하였다.
HIVgag(short) 서열을 가진 E1 결실된 SAdV-A1337 클론을 또한 제조하였다 (SEQ ID NO: 336; p2878). E1 결실된 SAdV-A1337 클론 (SEQ ID NO: 287), p2875를 I-CeuI 및 PI-SceI로 분해하였고, 제거된 단편을 I-CeuI 및 PI-SceI 부위를 통해 p0621 (SEQ ID NO: 394))의 메가뉴클레아제 카세트로 대체하였다.
실시예 5 - 벡터 확장 및 초기 특성화
HIVgag(short) 서열 (SEQ ID NO: 246; p2876)을 갖는 E1 결실된 SAdV-A1320 클론 및 HIVgag(short) 서열 (SEQ ID NO: 336; p2878) 을 갖는 E1 결실된 SAdV-A1337을 실시예 4, B. 및 D에서 설명된 바오 k같이 제조하였다. 클론들을 구조하였고 벡터를 통상적인 기술에 다라 확장하였다. 구조시 특성화는 두 개의 벡터가 세포 변성 효과 (CPE)를 보여준다는 것을 나타냈다. A1320 및 A1337 벡터 각각에 대하여 mL 당 5.26 x 1012 및 5.55 x 1012 입자의 역가를 얻었다. 내독소를 생산하지 않고 두 벡터를 생산하였다.
실시예 6 - 벡터 특성화 - 감염성 역가 비율
A. 과정
각 벡터에 대한 감염성 역가 비율을 Taqman TCID50™ 검정을 사용하여 결정하였다. 민감도, 재현 가능성 및 순환 시간을 개선하기 위해, 아데노바이러스 벡터에 대한 감염성 검정을 개발하였고 플라크 검정과 같은 표준 기술에 대한 대안으로 사용하였다. Taqman TCID50™ 검정은 벡터의 제한 희석 및 양성 웰의 민감성, 정량적 콜링(calling)에 대하여 실시간 PC를 사용하는 바이러스 DNA 복제의 50% 종료점 결정을 기반으로 한다. 간략히 말하면, 벡터를 단계적으로 희석하고 (10배 희석) 96-웰 플레이트 포맷에서 293 세포를 감염시키는데 사용하였다 (희석액 당 8개의 복제 웰). 3일 배양 기간 후, 복제된 DNA를 추출하고 전이 유전자 발현 카세트 (예를 들어, 폴리 A)에 특이적인 실시간 PCR 프라이머-프로브 세트를 사용하여 정량한다. 50% 종료점 결정을 카버스(Karbers) 공식을 기반으로 하는 기본적인 컴퓨터 프로그램에 의해 수행한다. 검정의 확인은 역가 (IU/ml) 및 입자 대 감염성 (P:I) 비율의 훌륭한 재현 가능성을 나타냈다 (데이터 미도시). P:I 비율은 더 감염성인 벡터 프렙(prep)을 나타내는 낮은 P:I 비율의 조제물의 감염성 측정값으로서 사용된다. 검정은 일관되게 플라크 검정 또는 세포 변성 효과 (CPE)의 관찰에 기초한 TCID50 검정으로 성취된 것들보다 훨씬 더 낮은 P:I 비율로 돌려놓는다. Taqman TCID50 유래된 P:I 비율이 벡터 서브타입 내에서 많은 일관성의 측정값으로서 가장 유용하다.
B. 결과
HIVgag(short) 서열 (SEQ ID NO: 246; p2876)을 가진 E1 결실된 SAdV-A1320 클론을 상기 A의 과정에 따라 테스트하였다. 8617의 감염성 역가 비율이 발견되었다.
HIVgag(short) 서열 (SEQ ID NO: 336; p2878)을 가진 E1 결실된 SAdV-A1337 클론을 상기 A의 과정에 따라 테스트하였다. 278의 감염성 역가 비율이 발견되었다.
실시예 7 - T-세포 유발
HIVgag(short) 서열 (SEQ ID NO: 246; p2876)을 가진 E1 결실된 SAdV-A1320 클론 및 HIVgag(short) 서열 (SEQ ID NO: 336; p2878)을 가진 E1 결실된 SAdV-A1337 클론을 실시예 4, B 및 D에서 설명된 바와 같이 제조한다. 클론을 구조하고 벡터를 통상적인 기술에 따라 확장하였다. Roy et al. ["Partial protection against H5N1 influenza in mice with a single dose of a chimpanzee adenovirus vector expressing nucleoprotein", Vaccine 25:6845-6851 (August 6, 2007)]에 포함된 프로토콜은, 본원에서 참고로 포함되며, 결과의 재조합 아데노바이러스의 T 세포 유발을 평가하기 위해 활용될 수도 있다.
HIV-1-gag-short 전이 유전자를 가지고 있는 대조군 벡터로서 HAdV5와 함께, 각 벡터의 1 x 1010개의 입자를 BALBc 마우스로 근육 내 주사한다. 동물을 벡터 투여 후 제7 일 또는 제8 일 및 제14 일에 희생시킨다. HIV-1 gag-short에 대한 T 세포 반응을 IFN-γ ELISPOT 검정으로 분석한다. T 세포 반응은 검출 가능하며, 제7 일 또는 제8 일에서 제14 일까지 증가한다.
실시예 8 - 시토킨 유발
A. 본원에서 설명된 아데노바이러스 벡터에 대한 시토킨 반응의 특성화를 Lin, et al., J Virol. 2007 November; 81(21): 11840-11849 (Vaccines Based on Novel Adeno-Associated Virus Vectors Elicit Aberrant CD8+ T-Cell Responses in Mice), 및 Lin, et al, Hum. Gene Ther. 2008 July; 19(7): 663-669 (Impact of Preexisting Vector Immunity on the Efficacy of Adeno-Associated Virus -Based HIV-1 Gag Vaccines)의 방법에 따라 수행하며, 효소-결합 면역 흡착 검정(Enzyme-linked immunosorbent assay), 인터페론-γ 효소-결합 면역 스폿 검정(Interferon-γ enzyme-linked immunospot assay), 및 세포 내 시토킨 염색(Intracellular cytokine staining; ICCS)을 포함한다.
특성화는 벡터 투여 후 유익한 시토킨 프로파일을 반영할 것으로 예상된다.
B. HadV5, SAdV36, SAdV1295, SAdV1309 및 SAdV1321 벡터와 함께, SAdV-A1320 (도 1의 "SAdV1320") 및 SAdV-A1337 (도 1의 "SAdV1337") 벡터의 1 x 1010개의 입자를 BALB 마우스로 근육 내 주사하였고 HIV-1 gag-short에 대한 T 세포 반응을 제8 일 및 제14 일에 IFN-γ ELISPOT으로 분석하였다. T 세포 반응을 면역 우성 HIVgag short CD8 T 세포 에피토프 AMQMLKETI (SEQ ID NO: 410)를 사용하여 분석하였다. 이 펩티드를 Mimotopes (호주 빅토리아 클레이튼)로 합성하였고 2 mg/ml로 디메틸 술폭시드 (DMSO)에 용해시켰다. 펩티드를 모든 실험에서 2 μg/ml의 농도로 사용하였고 DMSO 농도를 모든 최종 검정 혼합물에서 0.1 부피% 이하로 유지하였다. 벡터 및 시점 당 세 마리의 BALB/c 마우스에 해당 벡터를 주사하였다. 제8 일 및 제14 일의 T 세포 데이터의 요약은 도 1에서 제공된다.
상기 인용된 모든 문서, 서열 목록, 및 2012년 5월 18일에 출원된 미국 가특허 출원 번호 제61/649,007호, 및 2013년 3월 14일에 출원된 미국 가특허 출원 번호 제61/784,142호 전부는 본원에 참고로 포함된다. 많은 변형 및 변종이 상기-확인된 명세서의 범위에 포함되고 당업자에게 명백한 것으로 예상된다. 다른 꼬마유전자의 선택 또는 벡터 또는 면역 조절자의 선택 또는 투약과 같이, 조성물 및 공정에 대한 이러한 변형 및 변화는 본원에 첨부된 청구항의 범위 내에 있는 것으로 생각된다.
(서열 목록 무료 텍스트) 숫자 식별자 <223> 하에 무료 텍스트를 함유하는 서열에 대하여 다음 정보가 제공된다.
SEQ ID NO:
(무료 텍스트 포함)
<223> 하의 무료 텍스트
1 원숭이 아데노바이러스 A1302
2 합성 구조
3 합성 구조
4 합성 구조
5 합성 구조
6 합성 구조
7 합성 구조
8 합성 구조
9 합성 구조
10 합성 구조
11 합성 구조
12 합성 구조
13 합성 구조
14 합성 구조
15 합성 구조
16 합성 구조
17 합성 구조
18 합성 구조
19 합성 구조
20 원숭이 아데노바이러스 A1302
21 합성 구조
22 합성 구조
23 합성 구조
24 합성 구조
24 합성 구조
25 원숭이 아데노바이러스 A1320
26 합성 구조
27 합성 구조
28 합성 구조
29 합성 구조
30 합성 구조
31 합성 구조
32 합성 구조
33 합성 구조
34 합성 구조
35 합성 구조
36 합성 구조
37 합성 구조
38 합성 구조
39 합성 구조
40 합성 구조
41 합성 구조
42 합성 구조
43 합성 구조
44 합성 구조
45 원숭이 아데노바이러스 A1320
46 합성 구조
47 합성 구조
48 합성 구조
49 합성 구조
50 원숭이 아데노바이러스 A1331
51 합성 구조
52 합성 구조
53 합성 구조
54 합성 구조
55 합성 구조
56 합성 구조
57 합성 구조
58 합성 구조
59 합성 구조
60 합성 구조
61 합성 구조
62 합성 구조
63 합성 구조
64 합성 구조
65 합성 구조
66 합성 구조
67 합성 구조
68 합성 구조
69 합성 구조
70 원숭이 아데노바이러스 A1331
71 합성 구조
72 합성 구조
73 합성 구조
74 합성 구조
75 원숭이 아데노바이러스 A1331
76 합성 구조
77 원숭이 아데노바이러스 A1337
78 합성 구조
79 합성 구조
80 합성 구조
81 합성 구조
82 합성 구조
83 합성 구조
84 합성 구조
85 합성 구조
86 합성 구조
87 합성 구조
88 합성 구조
89 합성 구조
90 합성 구조
91 합성 구조
92 합성 구조
93 합성 구조
94 합성 구조
95 합성 구조
96 합성 구조
97 원숭이 아데노바이러스 A1337
98 합성 구조
99 합성 구조
100 합성 구조
101 합성 구조
102 원숭이 아데노바이러스 A1337
103 합성 구조
104 원숭이 아데노바이러스 A1302 클론
105 합성 구조
106 합성 구조
107 합성 구조
108 합성 구조
109 합성 구조
110 합성 구조
111 합성 구조
112 합성 구조
113 합성 구조
114 합성 구조
115 합성 구조
116 합성 구조
117 합성 구조
118 합성 구조
119 합성 구조
120 합성 구조
121 합성 구조
122 합성 구조
123 원숭이 아데노바이러스 A1302 클론
124 합성 구조
125 합성 구조
126 합성 구조
127 원숭이 아데노바이러스 A1320 클론
128 합성 구조
129 합성 구조
130 합성 구조
131 합성 구조
132 합성 구조
133 합성 구조
134 합성 구조
135 합성 구조
136 합성 구조
137 합성 구조
138 합성 구조
139 합성 구조
140 합성 구조
141 합성 구조
142 합성 구조
143 합성 구조
144 합성 구조
145 합성 구조
146 합성 구조
147 원숭이 아데노바이러스 A1320 클론
148 합성 구조
149 합성 구조
150 합성 구조
151 원숭이 아데노바이러스 A1331클론
152 합성 구조
153 합성 구조
154 합성 구조
155 합성 구조
156 합성 구조
157 합성 구조
158 합성 구조
159 합성 구조
160 합성 구조
161 합성 구조
162 합성 구조
163 합성 구조
164 합성 구조
165 합성 구조
166 합성 구조
167 합성 구조
168 합성 구조
169 합성 구조
170 합성 구조
171 원숭이 아데노바이러스 A1331 클론
172 합성 구조
173 합성 구조
174 합성 구조
175 원숭이 아데노바이러스 A1337 클론
176 합성 구조
177 합성 구조
178 합성 구조
179 합성 구조
180 합성 구조
181 합성 구조
182 합성 구조
183 합성 구조
184 합성 구조
185 합성 구조
186 합성 구조
187 합성 구조
188 합성 구조
189 합성 구조
190 합성 구조
191 합성 구조
192 합성 구조
193 합성 구조
194 원숭이 아데노바이러스 A1337 클론
195 합성 구조
196 합성 구조
197 합성 구조
198 pSh-HIV-short-gag-HIV 기반
199 합성 구조
200 pSh-HIV-short-gag-HIV 기반
201 pSR5-대장균 기반
202 pSR7 - 대장균 기반
203 pBleuSK I-PI - 대장균 기반
204 합성 구조 카세트
205 사카로미세스 세레비시애 기반
ICeuPISceI 카세트
206 p2870 - E1 결실된 분자적 클론, 원숭이 아데노바이러스 A1320 기반
207 합성 구조
208 합성 구조
209 합성 구조
210 합성 구조
211 합성 구조
212 합성 구조
213 합성 구조
214 합성 구조
215 합성 구조
216 합성 구조
217 합성 구조
218 합성 구조
219 합성 구조
220 합성 구조
221 합성 구조
222 합성 구조
223 합성 구조
224 합성 구조
225 합성 구조
226 합성 구조
227 합성 구조
228 합성 구조
229 합성 구조
230 합성 구조
231 합성 구조
232 합성 구조
233 합성 구조
234 합성 구조
235 합성 구조
236 합성 구조
237 합성 구조
238 p2870 - E1 결실된 분자적 클론, 원숭이 아데노바이러스 A1320 기반
R 클론, 원숭이 아데노바이러스 A1320 기반
239 합성 구조
240 합성 구조
241 합성 구조
242 합성 구조
243 합성 구조
244 합성 구조
245 합성 구조
246 HIVgagshort 삽입된 p2876 - E1 결실된 분자적 클론, 원숭이 아데노바이러스 A1320 기반
247 합성 구조
248 합성 구조
249 합성 구조
250 합성 구조
251 합성 구조
252 합성 구조
253 합성 구조
254 합성 구조
255 합성 구조
256 합성 구조
257 합성 구조
258 합성 구조
259 합성 구조
260 합성 구조
261 합성 구조
262 합성 구조
263 합성 구조
264 합성 구조
265 합성 구조
266 합성 구조
267 합성 구조
268 합성 구조
269 합성 구조
270 합성 구조
271 합성 구조
272 합성 구조
273 합성 구조
274 합성 구조
275 합성 구조
276 합성 구조
277 합성 구조
278 합성 구조
279 HIVgagshort 삽입된 p2876 - E1 결실된 분자적 클론, 원숭이 아데노바이러스 A1320 기반
280 합성 구조
281 합성 구조
282 합성 구조
283 합성 구조
284 합성 구조
285 합성 구조
286 합성 구조
287 p2875 - E1 결실된 분자적 클론, 원숭이 아데노바이러스 A1337 기반
288 합성 구조
289 합성 구조
290 합성 구조
291 합성 구조
292 합성 구조
293 합성 구조
294 합성 구조
295 합성 구조
296 합성 구조
297 합성 구조
298 합성 구조
299 합성 구조
300 합성 구조
301 합성 구조
302 합성 구조
303 합성 구조
304 합성 구조
305 합성 구조
306 합성 구조
307 합성 구조
308 합성 구조
309 합성 구조
310 합성 구조
311 합성 구조
312 합성 구조
313 합성 구조
314 합성 구조
315 합성 구조
316 합성 구조
317 합성 구조
318 합성 구조
319 합성 구조
320 합성 구조
321 합성 구조
322 합성 구조
323 합성 구조
324 합성 구조
325 합성 구조
326 합성 구조
327 p2875 - E1 결실된 분자적 클론, 원숭이 아데노바이러스 A1337 기반
328 합성 구조
329 합성 구조
330 합성 구조
331 합성 구조
332 합성 구조
333 합성 구조
334 합성 구조
335 합성 구조
336 HIVgagshort 삽입된 p2878 - E1 결실된 분자적 클론, 원숭이 아데노바이러스 A1337 기반
337 합성 구조
338 합성 구조
339 합성 구조
340 합성 구조
341 합성 구조
342 합성 구조
343 합성 구조
344 합성 구조
345 합성 구조
346 합성 구조
347 합성 구조
348 합성 구조
349 합성 구조
350 합성 구조
351 합성 구조
352 합성 구조
353 합성 구조
354 합성 구조
355 합성 구조
356 합성 구조
357 합성 구조
358 합성 구조
359 합성 구조
360 합성 구조
361 합성 구조
362 합성 구조
363 합성 구조
364 합성 구조
365 합성 구조
366 합성 구조
367 합성 구조
368 합성 구조
369 합성 구조
370 합성 구조
371 합성 구조
372 합성 구조
373 합성 구조
374 합성 구조
375 합성 구조
376 합성 구조
377 합성 구조
378 HIVgagshort 삽입된 p2878 - E1 결실된 분자적 클론, 원숭이 아데노바이러스 A1337 기반
379 합성 구조
380 합성 구조
381 합성 구조
382 합성 구조
383 합성 구조
384 합성 구조
385 합성 구조
386 합성 구조
387 합성 구조
388 합성 구조
389 합성 구조
390 합성 구조
391 p2311-HIV 기반 벡터
392 합성 구조
393 합성 구조
394 p0621-HIV 기반 벡터
395 합성 구조
396 합성 구조
397 합성 구조
398 합성 구조
399 합성 구조
400 합성 구조
401 합성 구조
402 합성 구조
403 합성 구조
404 합성 구조
405 합성 구조
406 합성 구조
407 합성 구조
408 합성 구조
409 합성 구조
410 HIVgag short CD8 T 세포 에피토프
SEQUENCE LISTING <110> THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA <120> Subfamily E Simian Adenoviruses A1302, A1320, A1331 and A1337 and Uses Thereof <130> UPN-Y6334PCT <150> US 61/649,007 <151> 2012-05-18 <150> US 61/784,142 <151> 2013-03-14 <160> 410 <170> PatentIn version 3.5 <210> 1 <211> 36430 <212> DNA <213> Unknown <220> <223> Simian adenovirus A1302 <220> <221> CDS <222> (1590)..(2168) <223> E1b\19K <220> <221> misc_feature <222> (3983)..(5604) <223> IVa2 complement (3983..5313,5593..5604) <220> <221> misc_feature <222> (5593)..(13883) <223> pol complement (5593..8652,13825..13883) <220> <221> misc_feature <222> (6483)..(6483) <223> is g or c <220> <221> misc_feature <222> (8560)..(13833) <223> pTP complement (8560..10391,13825..13833) <220> <221> CDS <222> (10828)..(12006) <223> 52K <220> <221> CDS <222> (12033)..(13790) <223> pIIIa <220> <221> CDS <222> (13873)..(15456) <223> penton <220> <221> CDS <222> (16092)..(17123) <223> V <220> <221> CDS <222> (17149)..(17379) <223> pX <220> <221> CDS <222> (17451)..(18173) <223> pVI <220> <221> CDS <222> (18217)..(21066) <223> hexon <220> <221> CDS <222> (21085)..(21711) <223> protease <220> <221> misc_feature <222> (21796)..(23328) <223> DBP complement (21796..23328) <220> <221> CDS <222> (23354)..(25744) <223> 100K <220> <221> misc_feature <222> (25720)..(25720) <223> is a or g <220> <221> CDS <222> (26367)..(27047) <223> pVIII <220> <221> CDS <222> (27051)..(27368) <223> E3\12.5K <220> <221> CDS <222> (27930)..(28457) <223> E3\gp19K <220> <221> CDS <222> (28490)..(29083) <223> E3\CR1-beta <220> <221> CDS <222> (29099)..(29707) <223> E3\CR1-gamma <220> <221> CDS <222> (29725)..(30597) <223> E3\CR1-delta <220> <221> CDS <222> (30889)..(31317) <223> E3\RID-beta <220> <221> CDS <222> (32014)..(33333) <223> fiber <220> <221> misc_feature <222> (32502)..(32502) <223> is a or c <220> <221> misc_feature <222> (33431)..(34764) <223> E4\orf6/7 complement (33431..33681,34414..34764) <220> <221> misc_feature <222> (33682)..(34584) <223> E4\orf6 complement (33682..34584) <220> <221> misc_feature <222> (34493)..(34855) <223> E4\orf4 complement (34493..34855) <220> <221> misc_feature <222> (34868)..(35218) <223> E4\orf3 complement (34868..35218) <220> <221> misc_feature <222> (35218)..(35604) <223> E4\orf2 complement (35218..35604) <400> 1 catcatcaat aatatacctc aaactttttg tgcgtgttaa tatgcaaatg aggcgtttga 60 atttggggct gcggggctgt gattggctgc gggagcggcg accgttaggg gcggggcggg 120 tgacgtttcg atgacgtgac gtgaggcgga gccggtttgc aagttctcgt gggaaaagtg 180 acgtcaaacg aggtgtggtt tgaacacgga aatactcaat tttcccgcgc tctctgacag 240 gaaatgaggt gtttctgggc ggatgcaagt gaaaacgggc cattttcgcg cgaaaactaa 300 atgaggaagt gaaaatctga gtaattccgc gtttatggca gggaggagta tttgccgagg 360 gccgagtaga ctttgaccga ttacgtgggg gtttcgatta ccgtattttt cacctaaatt 420 tccgcgtacg gtgtcaaagt ccggtgtttt tacgtaggcg tcagctgatc gccagggtat 480 ttaaacctgc gctctctagt caagaggcca ctcttgagtg ccagcgagta gagttttctc 540 ctccgcgccg cgagtcagat ctacactttg aaagatgagg cacctgagag acctgcccgg 600 taatgttttc ctggctactg ggaacgagat tctggaactg gtggtggacg ccatgatggg 660 tgacgaccct cctgagcccc ctaccccatt tgaggcgcct tcgctgtacg atttgtatga 720 tctggaggtg gatgtgcccg agaacgaccc caacgaggag gcggtgaatg atttgtttag 780 cgatgccgcg ctgctggctg ccgagcaggc taatacggac tctggctcag acagcgattc 840 ttctctccat accccgagac ctggcagagg tgagaaaaag attcccgagc ttaaagggga 900 agagctggac ctgcgctgct atgaggaatg cttgcctccg agcgatgatg aggaggacga 960 ggaggcgatc cgagctgcgg cgaaccaggg agtgaaagct gcgggcgaga gctttagcct 1020 ggactgtcct actctgcccg gacacggctg taagtcttgt gaatttcatc gcatgaatac 1080 tggagataag aatgtgatgt gtgccctgtg ctatatgaga gcttacaacc attgtgttta 1140 cagtaagtgt gattaacttt agttgggaag gcagagggtg actgggtgct gactggttta 1200 tttatgtata tgttttttta tgtgtaggtc ccgtctctga cgtagatgag acccccactt 1260 cagagtgcat ttcatcaccc ccagaaattg gcgaggaacc gcccgaagat attattcata 1320 gaccagttgc agtgagagtc accgggcgta gagcagctgt ggagagtttg gatgacttgc 1380 tacagggtgg ggatgaacct ttggacttgt gtacccggaa acgccccagg cactaagtgc 1440 cacacatgtg tgtttactta aggtgatgtc agtatttata gggtgtggag tgcaataaaa 1500 tccgtgttga ctttaagtgc gtggtttatg actcaggggt gggtatataa gcaggtgcag 1560 acctgtgtgg tcagttcaga gcaggactc atg gag atc tgg acg gtc ttg gaa 1613 Met Glu Ile Trp Thr Val Leu Glu 1 5 gac ttt cac cag act aga cag ctg cta gag aac tca tcg gag gaa gtc 1661 Asp Phe His Gln Thr Arg Gln Leu Leu Glu Asn Ser Ser Glu Glu Val 10 15 20 tct tac ctg tgg aga ttt tgc ttc ggt ggg gct cta gct aag cta gtc 1709 Ser Tyr Leu Trp Arg Phe Cys Phe Gly Gly Ala Leu Ala Lys Leu Val 25 30 35 40 cat agg gcc aaa cag gat tat aag gat caa ttt gag gat att ttg aga 1757 His Arg Ala Lys Gln Asp Tyr Lys Asp Gln Phe Glu Asp Ile Leu Arg 45 50 55 gag tgt cct ggt att ttt gac tct ctc aac ttg ggc cat cag tct cac 1805 Glu Cys Pro Gly Ile Phe Asp Ser Leu Asn Leu Gly His Gln Ser His 60 65 70 ttt aac cag agt att ctg aga gcc ctt gac ttt tct act cct ggc aga 1853 Phe Asn Gln Ser Ile Leu Arg Ala Leu Asp Phe Ser Thr Pro Gly Arg 75 80 85 act acc gcc gcg gta gcc ttt ttt gcc ttt att ctt gac aaa tgg agt 1901 Thr Thr Ala Ala Val Ala Phe Phe Ala Phe Ile Leu Asp Lys Trp Ser 90 95 100 caa gaa acc cat ttc agc agg gat tac cgt ctg gac tgc tta gca gta 1949 Gln Glu Thr His Phe Ser Arg Asp Tyr Arg Leu Asp Cys Leu Ala Val 105 110 115 120 gct ttg tgg aga aca tgg agg tgc cag cgc ctg aat gca atc tcc ggc 1997 Ala Leu Trp Arg Thr Trp Arg Cys Gln Arg Leu Asn Ala Ile Ser Gly 125 130 135 tac ttg cca gta cag ccg gta gac acg ctg agg atc ctg agt ctc cag 2045 Tyr Leu Pro Val Gln Pro Val Asp Thr Leu Arg Ile Leu Ser Leu Gln 140 145 150 tca ccc cag gaa cac caa cgc cgc cag cag ccg cag cag gag cag cag 2093 Ser Pro Gln Glu His Gln Arg Arg Gln Gln Pro Gln Gln Glu Gln Gln 155 160 165 caa gag gag gag gag gag gac cga gaa gag aac ccg aga gcc ggt ctg 2141 Gln Glu Glu Glu Glu Glu Asp Arg Glu Glu Asn Pro Arg Ala Gly Leu 170 175 180 gac cct ccg gtg gcg gag gag gag gag tagctgactt gtttcccgag 2188 Asp Pro Pro Val Ala Glu Glu Glu Glu 185 190 ctgcgccggg tgctgactag gtcttccagt ggacgggaga gggggattaa gcgggagagg 2248 catgaggaga ctagtcacag aactgaactg actgtcagtc tgatgagccg caggcgccca 2308 gaatcggtgt ggtggcatga ggtgcagtcg caggggatag atgaggtctc agtgatgcat 2368 gagaaatatt ccctagaaca agtcaagact tgttggttgg agcccgagga tgattgggag 2428 gtagccatca ggaattatgc caagctggct ctgaagccag acaagaagta caagattacc 2488 aaactgatta atatcagaaa ttcctgctac atttcaggga atggggccga ggtggagatc 2548 agtacccagg agagggtggc cttcagatgc tgcatgatga atatgtaccc gggggtggtg 2608 ggcatggagg gagtcacctt tatgaacgcg aggttcaggg gcgatgggta taatggggtg 2668 gtctttatgg ccaacaccaa gctgacagtg cacggatgct ccttctttgg cttcaataac 2728 atgtgcatcg aggcctgggg cagtgtttca gtgaggggat gcagcttttc agccaactgg 2788 atgggggtcg tgggcagaac caagagcaag gtgtcagtga agaaatgcct gttcgagagg 2848 tgccacatgg gggtgatgag cgagggcgaa gccaaagtca aacactgcgc ctctaccgag 2908 acgggctgct ttgtgctgat caagggcaat gcccaagtca agcataacat gatctgtggg 2968 gcctcggatg agcgcggcta ccagatgctg acctgtgccg gtgggaacag ccatatgctg 3028 gccaccgtgc atgtggcctc gcacccccgc aagacatggc ccgagttcga gcataacgtc 3088 atgacccgct gcaatgtgca cctgggctcc cgccgaggca tgttcatgcc ctaccagtgc 3148 aacatgcaat ttgtgaaggt gctgctggag cccgatgcca tgtccagagt gagtctgacg 3208 ggggtgtttg acatgaatgt ggagatgtgg aaaattctga gatatgatga atccaagacc 3268 aggtgccggg cctgcgaatg cggaggcaaa cacgccaggc ttcagcccgt gtgtgtggag 3328 gtgacggagg acctgcgacc cgatcatttg gtgttgtcct gcaacgggac ggagttcggc 3388 tccagcgggg aagaatctga ctagagtgag tagtgtttgg ggctgggtgg gagcctgcat 3448 gatgggcaga atgactaaaa tctgtgtttt tctgcgcagc atcatgagcg gaagcgcctc 3508 ctttgaggga ggggtattca gcccttatct gacggggcgt ctcccctcct gggcgggagt 3568 gcgtcagaat gtgatgggat ccacggtgga cggccggccc gtgcagcccg cgaactcttc 3628 aaccctgacc tacgcgaccc tgagctcctc gtccgtagac gcagctgccg ccgcagctgc 3688 tgcttccgcc gccagcgccg tgcgcggaat ggccctgggc gccggctact acagctctct 3748 ggtggccaac tcgagttcca ccaataatcc cgccagcctg aacgaggaga agctgctgct 3808 gctgatggcc cagctcgagg ccctgaccca gcgcctgggc gagctgaccc agcaggtggc 3868 tcagctgcag gcggagacgc gggccgcggt tgccacggtg aaaaccaaat aaaaaatgaa 3928 tcaataaata aacggagacg gttgttgatt ttaacacaga gtcttgaatc tttatttgat 3988 ttttcgcgcg cggtaggccc tggaccaccg gtctcgatca ttgagcaccc ggtggatttt 4048 ttccaggacc cggtagaggt gggcttggat gttgaggtac atgggcatga gcccgtcccg 4108 ggggtggagg tagctccatt gcagggcctc gtgctcgggg gtggtgttgt aaatcaccca 4168 gtcatagcag gggcgcaggg cgtggtgctg cacgatgtcc ttgaggagga gactgatggc 4228 cacgggcagc cccttggtgt aggtgttgac gaacctgttg agctgggagg gatgcatgcg 4288 gggggagatg agatgcatct tggcctggat cttgagattg gcgatgttcc cgcccagatc 4348 ccgccggggg ttcatgttgt gcaggaccac cagcacggtg tatccggtgc acttggggaa 4408 tttgtcatgc aacttggaag ggaaggcgtg aaagaatttg gagacgccct tgtgaccgcc 4468 caggttttcc atgcactcat ccatgatgat ggcgatgggc ccgtgggcgg cggcctgggc 4528 aaagacgttt cgggggtcgg acacatcgta gttgtggtcc tgggtgagct cgtcataggc 4588 cattttaatg aatttggggc ggagggtgcc cgactggggg acaaaggtgc cctcgatccc 4648 gggggcgtag tttccctcgc agatctgcat ctcccaggcc ttgagctcgg agggggggat 4708 catgtccacc tgcggggcga tgaaaaaaac ggtttccggg gcgggggaga tgagctgggc 4768 cgaaagcagg ttccggagca gctgggactt gccgcagccg gtggggccgt agatgacccc 4828 gatgaccggc tgcaggtggt agttgaggga gagacagctg ccgtcctcgc ggaggagggg 4888 ggccacctcg ttcatcatct cgcgcacatg catgttctcg cgcacgagtt ccgccaggag 4948 gcgctcgccc cccagcgaga ggagctcttg cagcgaggcg aagtttttca gcggtttgag 5008 cccgtcggcc atgggcattt tggagagggt ctgttgcaag agttccagac ggtcccagag 5068 ctcggtgatg tgctctaggg catctcgatc cagcagacct cctcgtttcg cgggttgggg 5128 cgactgcggg agtagggcac caggcgatgg gcgtccagcg aggccagggt ccggtccttc 5188 caggggcgca gggtccgcgt cagcgtggtc tccgtcacgg tgaaggggtg cgcgccgggc 5248 tgggcgcttg cgagggtgcg cttcaggctc atccggctgg tcgagaaccg ctcccggtcg 5308 gcgccctgcg cgtcggccag gtagcaattg agcatgagtt cgtagttgag cgcctcggcc 5368 gcgtggccct tggcgcggag cttacctttg gaagtgtgtc cgcagacggg acagaggagg 5428 gacttgaggg cgtagagctt gggggcgagg aagacggact cgggggcgta ggcgtccgcg 5488 ccgcagctgg cgcagacggt ctcgcactcc acgagccagg tgaggtcggg gcggtcgggg 5548 tcaaaaacga ggtttcctcc gtgctttttg atgcgtttct tacctctggt ctccatgagc 5608 tcgtgtcccc gctgggtgac aaagaggctg tccgtgtccc cgtagaccga ctttatgggc 5668 cggtcctcga gcggggtgcc gcggtcctcg tcgtagagga accccgccca ctccgagacg 5728 aaggcccggg tccaggccag cacgaaggag gccacgtggg aggggtagcg gtcgttgtcc 5788 accagcgggt ccaccttctc cagggtatgc aagcacatgt ccccctcgtc cacatccagg 5848 aaggtgattg gcttgtaagt gtaggccacg tgaccggggg tcccggccgg gggggtataa 5908 aagggggcgg gcccctgctc gtcctcactg tcttccggat cgctgtccag gagcgccagc 5968 tgttggggta ggtattccct ctcgaaggcg ggcatgacct cggcactcag gttgtcagtt 6028 tctagaaacg aggaggattt gatattgacg gtgccgttgg agacgccttt catgagcccc 6088 tcgtccatct ggtcagaaaa gacgatcttt ttgttgtcga gcttggtggc gaaggagccg 6148 tagagggcat tggagaggag cttggcgatg gagcgcatgg tctggttctt ttccttgtcg 6208 gcgcgctcct tggcggcgat gttgagctgc acgtactcgc gcgccacgca cttccattcg 6268 gggaagacgg tggtgagctc gtcgggcacg attctgaccc gccagccgcg gttgtgcagg 6328 gtgatgaggt ccacgctggt ggccacctcg ccgcgcaggg gctcgttggt ccagcagagg 6388 cgcccgccct tgcgcgagca gaaggggggc agcgggtcca gcatgagctc gtcggggggg 6448 tcggcgtcca cggtgaagat gccgggcagg agctcggggt cgaagtagct gatgcaggtg 6508 cccagatcgt ccagcgccgc ttgccagtcg cgcacggcca gcgcgcgctc gtaggggctg 6568 aggggcgtgc cccagggcat ggggtgcgtg agcgcggagg cgtacatgcc gcagatgtcg 6628 tagacgtaga ggggctcctc gaggacgccg atgtaggtgg ggtagcagcg ccccccgcgg 6688 atgctggcgc gcacgtagtc gtacagctcg tgcgagggcg cgaggagccc cgcgccgagg 6748 ttggagcgct gcggcttttc ggcgcggtag acgatctggc ggaagatggc gtgggagttg 6808 gaggagatgg tgggcctctg gaagatgttg aagtgggcgt ggggcaggcc gaccgagtcc 6868 ctgatgaagt gggcgtagga gtcctgcagc ttggcgacga gctcggcggt gacgaggacg 6928 tccagggcgc agtagtcgag ggtctcttgg atgatgtcgt acttgagctg gcccttctgc 6988 ttccacagct cgcggttgag aaggaactct tcgcggtcct tccagtactc ttcgaggggg 7048 aacccgtcct gatcggcacg gtaagagccc accatgtaga actggttgac ggccttgtag 7108 gcgcagcagc ccttctccac ggggagggca taagcttgcg cggccttgcg cagggaggtg 7168 tgggtgaggg cgaaggtgtc gcgcaccatg accttgagga actggtgctt gaagtcgagg 7228 tcgtcgcagc cgccctgctc ccagagttgg aagtccgtgc gcttcttgta ggcggggttg 7288 ggcaaagcga aagtaacatc gttgaagagg atcttgcccg cgcggggcat gaagttgcga 7348 gtgatgcgga aaggctgggg cacctcggcc cggttgttga tgacctgggc ggcgaggacg 7408 atctcgtcga agccgttgat gttgtgcccg acgatgtaga gttccacgaa tcgcgggcgg 7468 cccttgacgt ggggcagctt cttgagctcg tcgtaggtga gctcggcggg gtcgctgagt 7528 ccgtgctgct caagggccca gtcggcgacg tgggggttgg cgctgaggaa ggaagtccag 7588 agatccacgg ccagggcggt ttgcaagcgg tcccggtact gacggaactg ctggcccacg 7648 gccatttttt cgggggtgat gcagtagaag gtgcgggggt cgccgtgcca gcggtcccac 7708 ttgagctgga gggcgaggtc gtgggcgagc tcgacgagcg gcgggtcccc ggagagtttc 7768 atgaccagca tgaaggggac gagctgcttg ccgaaggacc ccatccaggt gtaggtttcc 7828 acatcgtagg tgaggaagag cctttcggtg cgaggatgcg agccgatggg gaagaactgg 7888 atctcctgcc accagttgga ggaatggctg ttgatgtgat ggaagtagaa atgccgacgg 7948 cgcgccgagc actcgtgctt gtgtttatac aagcgtccgc agtgctcgca acgctgcacg 8008 ggatgcacgt gctgcacgag ctgtacctga gttcctttga cgaggaattt cagtgggcag 8068 tggagcgctg gcggctgcat ctggtgctgt actacgtcct ggccatcggc gtggccatcg 8128 tctgcctcga tggtggtcat gctgacgagc ccgcgcggga ggcaggtcca gacctcgact 8188 cggacgggtc ggagagcgag gacgagggcg cgcaggccgg agctgtccag ggtcctgaga 8248 cgctgcggag tcaggtcagt gggcagcggc ggcgcgcggt tgacttgcag gagcttttcc 8308 agggcgcgcg ggaggtccag atggtacttg atctccacgg cgccgttggt ggcgacgtcc 8368 acggcttgca gggtcccgtg cccctggggc gccaccaccg tgccccgttt cttcttgggc 8428 gctggcgttg gcgctgcttc catgtcggtc agaagcggcg gcgaggacgc gcgccgggcg 8488 gcaggggcgg ctcggggccc ggaggcaggg gcggcagggg cacgtcggcg ccgcgcgcgg 8548 gcaggttctg gtactgcgcc cggagaagac tggcgtgagc gacgacgcga cggttgacgt 8608 cctggatctg acgcctctgg gtgaaggcca cgggacccgt gagtttgaac ctgaaagaga 8668 gttcgacaga atcaatctcg gtatcgttga cggcggcctg ccgcaggatc tcttgcacgt 8728 cgcccgagtt gtcctggtag gcgatctcgg tcatgaactg ctcgatctcc tcctcctgaa 8788 ggtctccgcg gccggcgcgc tccacggtgg ccgcgaggtc gttggagatg cggcccatga 8848 gctgcgagaa ggcgttcatg cccgcctcgt tccagacgcg gctgtagacc acgacgccct 8908 cgggatcgcg ggcgcgcatg accacctggg cgaggttgag ctccacgtgg cgcgtgaaga 8968 ccgcgtagtt gcagaggcgc tggtagaggt agttgagcgt ggtggcgatg tgctcggtga 9028 cgaagaaata catgatccag cggcggagcg gcatctcgct gacgtcgccc agcgcctcca 9088 agcgttccat ggcctcgtaa aagtccacgg cgaagttgaa aaactgggag ttgcgcgccg 9148 agacggtcaa ctcctcctcc agaagacgga tgagctcggc gatggtggcg cgcacctcgc 9208 gctcgaaggc ccccgggagt tcctccactt cctcttcttc ttcctcctcc actaacatct 9268 cttctacttc ctcctcaggc ggtggtggcg ggggaggggg cctgcgtcgc cggcggcgca 9328 cgggcagacg gtcgatgaag cgctcgatgg tctcgccgcg ccggcgtcgc atggtctcgg 9388 tgacggcgcg cccgtcctcg cggggccgca gcgtgaagac gccgccgcgc atctccaggt 9448 ggccgggggg gtccccgttg ggcagggaga gggcgctgac gatgcatctt atcaattgcc 9508 ccgtagggac tccgcgcaag gacctgagcg tctcgagatc cacgggatct gaaaaccgtt 9568 gaacgaaggc ttcgagccag tcgcagtcgc aaggtaggct gagcacggtt tcttctggcg 9628 ggtcatgttg gttggaggga gcggggcggg cgatgctgct ggtgatgaag ttgaaatagg 9688 cggttctgag acggcggatg gtggcgagga gcaccaggtc tttgggcccg gcttgctgga 9748 tgcgcagacg gtcggccatg ccccaggcgt ggtcctgaca cctggccagg tccttgtagt 9808 agtcctgcat gagccgctcc acgggcacct cctcctcgcc cgcgcggccg tgcatgcgcg 9868 tgagcccgaa cccgcgctgc ggctggacga gcgccaggtc ggcgacgacg cgctcggcga 9928 ggatggcctg ctggatctgg gtgagggtgg tctggaagtc gtcaaagtcg acgaagcggt 9988 ggtaggctcc ggtgttgatg gtgtaggagc agttggccat gacggaccag ttgacggtct 10048 ggtggcccgg acgcacgagc tcgtggtact tgaggcgcga gtaggcgcgc gtgtcgaaga 10108 tgtagtcgtt gcaggtgcgc accaggtatt ggtagccgat gaggaagtgc ggcggcggct 10168 ggcggtagag cggccatcgc tcggtggcgg gggcgccggg cgcgaggtcc tcgagcatga 10228 ggcggtggta gccgtagatg tacctggaca tccaggtgat gccggcggcg gtggtggagg 10288 cgcgcgggaa ctcgcggacg cggttccaga tgttgcgcag cggcaggaag tagttcatgg 10348 tggccgcggt ctggcccgtg aggcgcgcgc agtcgtggat gctctagaca tacgggcaaa 10408 aacgaaagcg gtcagcggct cgactccgtg gcctggaggc taagcgaacg ggttgggctg 10468 cgcgtgtacc ccggttcgaa tctcgaatca ggctggagcc gcagctaacg tggtactggc 10528 actcccgtct cgacccaagc ctgctaacga aacctccagg atacggaggc gggtcgtttt 10588 ggcatttttc gtcaggccgg aaatgaaact agtaagcgcg gaaagcggcc gaccgcgatg 10648 gctcgctgcc gtagtctgga gaagaatcgc cagggttgcg ttgcggtgtg ccccggttcg 10708 aggccggccg gattccgcgg ctaacgaggg cgtggctgcc ccgtcgtttc caagacccct 10768 agccagccga cttctccagt tacggagcga gcccctcttt tgttttttgt ttttgccag 10827 atg cat ccc gta ctg cgg cag atg cgc ccc cac cac cct cca ccg caa 10875 Met His Pro Val Leu Arg Gln Met Arg Pro His His Pro Pro Pro Gln 195 200 205 caa cag ccc cct cca cag ccg gcg ctt ctg ccc ccg ccc cag cag cag 10923 Gln Gln Pro Pro Pro Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln 210 215 220 225 cag caa ctt cca gcc acg acc gcc gcg gcc gcc gtg agc ggg gct gga 10971 Gln Gln Leu Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala Gly 230 235 240 cag agt tat gac cac cag ctg gcc ttg gaa gag ggc gag ggg ctg gcg 11019 Gln Ser Tyr Asp His Gln Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala 245 250 255 cgg ctg ggg gcg tcg tcg ccg gag cgg cac ccg cgc gtg cag atg aaa 11067 Arg Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys 260 265 270 agg gac gct cgc gag gcc tac gtg ccc aag cag aac ctg ttc aga gac 11115 Arg Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp 275 280 285 agg agc ggc gag gag ccc gag gag atg cgc gcc tcc cgc ttc cac gcg 11163 Arg Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ser Arg Phe His Ala 290 295 300 305 ggg cgg gag ctg cgg cgc ggc ctg gac cga aag cgg gtg ctg agg gac 11211 Gly Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp 310 315 320 gag gat ttc gag gcg gac gag ctg acg ggg atc agc ccc gcg cgc gcg 11259 Glu Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala 325 330 335 cac gtg gcc gcg gcc aac ctg gtc acg gcg tac gag cag acc gtg aag 11307 His Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys 340 345 350 gag gag agc aac ttc caa aaa tcc ttc aac aac cac gtg cgc acc ttg 11355 Glu Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu 355 360 365 atc gcg cgc gag gag gtg acc ctg ggc ctg atg cac ctg tgg gac ctg 11403 Ile Ala Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu 370 375 380 385 ctg gag gcc atc gtg cag aac ccc acg agc aag ccg ctg acg gcg cag 11451 Leu Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln 390 395 400 ctg ttt ctg gtg gtg cag cac agt cgg gac aac gag acg ttc agg gag 11499 Leu Phe Leu Val Val Gln His Ser Arg Asp Asn Glu Thr Phe Arg Glu 405 410 415 gcg ctg ctg aat atc acc gag ccc gag ggc cgt tgg ctc ctg gac ctg 11547 Ala Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu 420 425 430 gtg aac att ctg cag agc atc gtg gtg cag gag cgc ggg ctg ccg ctg 11595 Val Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu 435 440 445 tcc gag aag ctg gcg gcc atc aac ttc tcg gtg ctg agc ctg ggc aag 11643 Ser Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys 450 455 460 465 tac tac gct agg aag atc tac aag acc ccg tac gtg ccc ata gac aag 11691 Tyr Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys 470 475 480 gag gtg aag atc gat ggg ttt tac atg cgc atg acc ctg aaa gtg ctg 11739 Glu Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu 485 490 495 acc ctg agc gac gat ctg ggg gtg tac cgc aac gac agg atg cac cgc 11787 Thr Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg 500 505 510 gcg gtg agc gcc agc cgc cgg cgc gag ctg agc gac cag gag ctg atg 11835 Ala Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met 515 520 525 cac agc ctg cag cgg gcc ctg acc ggg gcc ggg acc gag ggg gag agc 11883 His Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser 530 535 540 545 tac ttt gac atg ggc gcg gac ctg cgc tgg cag ccc agc cgc cgg gcc 11931 Tyr Phe Asp Met Gly Ala Asp Leu Arg Trp Gln Pro Ser Arg Arg Ala 550 555 560 ttg gaa gct gcc ggc ggc gtg ccc tac gtg gag gag gtg gac gat gag 11979 Leu Glu Ala Ala Gly Gly Val Pro Tyr Val Glu Glu Val Asp Asp Glu 565 570 575 gag gag gag ggc gag tac ctg gaa gac tgatggcgcg accgtatttt tgctag 12032 Glu Glu Glu Gly Glu Tyr Leu Glu Asp 580 585 atg cag caa cag cca ccg cct cct gat ccc gcg atg cgg gcg gcg ctg 12080 Met Gln Gln Gln Pro Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu 590 595 600 cag agc cag ccg tcc ggc att aac tcc tcg gac gat tgg acc cag gcc 12128 Gln Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala 605 610 615 atg caa cgc atc atg gcg ctg acg acc cgc aat ccc gaa gcc ttt aga 12176 Met Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg 620 625 630 cag cag cct cag gcc aac cgg ctc tcg gcc atc ctg gag gcc gtg gtg 12224 Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val 635 640 645 650 ccc tcg cgc tcg aac ccc acg cac gag aag gtg ctg gcc atc gtg aac 12272 Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn 655 660 665 gcg ctg gtg gag aac aag gcc atc cgc ggc gac gag gcc ggg ctg gtg 12320 Ala Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val 670 675 680 tac aac gcg ctg ctg gag cgc gtg gcc cgc tac aac agc acc aac gtg 12368 Tyr Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val 685 690 695 cag acg aac ctg gac cgc atg gtg acc gac gtg cgc gag gcg gtg tcg 12416 Gln Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ser 700 705 710 cag cgc gag cgg ttc cac cgc gag tcg aac ctg ggc tcc atg gtg gcg 12464 Gln Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala 715 720 725 730 ctg aac gcc ttc ctg agc acg cag ccc gcc aac gtg ccc cgg ggc cag 12512 Leu Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln 735 740 745 gag gac tac acc aac ttc atc agc gcg ctg cgg ctg atg gtg gcc gag 12560 Glu Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Ala Glu 750 755 760 gtg ccc cag agc gag gtg tac cag tcg ggg ccg gac tac ttc ttc cag 12608 Val Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln 765 770 775 acc agt cgc cag ggc ttg cag acc gtg aac ctg agc cag gct ttc aag 12656 Thr Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys 780 785 790 aac ttg cag gga ctg tgg ggc gtg cag gcc ccg gtc ggg gac cgc gcg 12704 Asn Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala 795 800 805 810 acg gtg tcg agc ctg ctg acg ccg aac tcg cgc ctg ctg ctg ctg ctg 12752 Thr Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu 815 820 825 gtg gcg ccc ttc acg gac agc ggc agc gtg agc cgc gac tcg tac ctg 12800 Val Ala Pro Phe Thr Asp Ser Gly Ser Val Ser Arg Asp Ser Tyr Leu 830 835 840 ggc tac ctg ctt aac ctg tac cgc gag gcc atc ggg cag gcg cac gtg 12848 Gly Tyr Leu Leu Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val 845 850 855 gac gag cag acc tac cag gag atc acc cac gtg agc cgc gcg ctg ggg 12896 Asp Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly 860 865 870 cag gag gac ccg ggc aac ctg gag gcc acc ctg aac ttc ctg ctg acc 12944 Gln Glu Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr 875 880 885 890 aac cgg tcg cag aag atc ccg ccc cag tac gcg ctg agc acc gag gag 12992 Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu 895 900 905 gag cgc atc ctg cgc tac gtg cag cag agc gtg ggg ctg ttc ctg atg 13040 Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met 910 915 920 cag gag ggg gcc acg ccc agc gcc gcg ctc gac atg acc gcg cgc aac 13088 Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn 925 930 935 atg gag ccc agc atg tac gcc cgc aac cgc ccg ttc atc aat aag ctg 13136 Met Glu Pro Ser Met Tyr Ala Arg Asn Arg Pro Phe Ile Asn Lys Leu 940 945 950 atg gac tac ttg cat cgg gcg gcc gcc atg aac tcg gac tac ttt acc 13184 Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr 955 960 965 970 aac gcc atc ttg aac ccg cac tgg ctc ccg ccg ccc ggg ttc tac acg 13232 Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr 975 980 985 ggc gag tac gac atg ccc gac ccc aac gac ggg ttc ctg tgg gac gac 13280 Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp 990 995 1000 gtg gac agc agc gtg ttc tcg ccg cgc ccc acc acc acc gtg tgg 13325 Val Asp Ser Ser Val Phe Ser Pro Arg Pro Thr Thr Thr Val Trp 1005 1010 1015 aag aaa gag ggc ggg gac cgg cgg ccg tcc tcg gcg ctg tcc ggt 13370 Lys Lys Glu Gly Gly Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly 1020 1025 1030 cgc gcg ggt gct gcc gcg gcg gtg ccc gag gcc gcc agc ccc ttc 13415 Arg Ala Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe 1035 1040 1045 ccg agc ctg ccc ttt tcg ctg aac agc gtg cgc agc agc gag ctg 13460 Pro Ser Leu Pro Phe Ser Leu Asn Ser Val Arg Ser Ser Glu Leu 1050 1055 1060 ggt cgg ctg acg cgg ccg cgc ctg ctg ggc gag gag gag tac ctg 13505 Gly Arg Leu Thr Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu 1065 1070 1075 aac gac tcc ttg ttg agg ccc gag cgc gag aaa aac ttc ccc aat 13550 Asn Asp Ser Leu Leu Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn 1080 1085 1090 aac ggg ata gag agc ctg gtg gac aag atg agc cgc tgg aag acg 13595 Asn Gly Ile Glu Ser Leu Val Asp Lys Met Ser Arg Trp Lys Thr 1095 1100 1105 tac gcg cac gag cac agg gac gag ccc cga gct agc agc agc acc 13640 Tyr Ala His Glu His Arg Asp Glu Pro Arg Ala Ser Ser Ser Thr 1110 1115 1120 ggc gcc cgt aga cgc cag cgg cac gac agg cag cgg gga ctg gtg 13685 Gly Ala Arg Arg Arg Gln Arg His Asp Arg Gln Arg Gly Leu Val 1125 1130 1135 tgg gac gat gag gat tcc gcc gac gac agc agc gtg ttg gac ttg 13730 Trp Asp Asp Glu Asp Ser Ala Asp Asp Ser Ser Val Leu Asp Leu 1140 1145 1150 ggt ggg agt ggt ggt ggt aac ccg ttc gct cac ctg cgc ccc cgt 13775 Gly Gly Ser Gly Gly Gly Asn Pro Phe Ala His Leu Arg Pro Arg 1155 1160 1165 atc ggg cgc ctg atg taagaatctg aaaaaataaa aaaacggtac tcaccaaggc 13830 Ile Gly Arg Leu Met 1170 catggcgacc agcgtgcgtt cttctctgtt gtttgtagta gt atg atg agg cgc 13884 Met Met Arg Arg 1175 gtg tac ccg gag ggt cct cct ccc tcg tac gag agc gtg atg cag 13929 Val Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser Val Met Gln 1180 1185 1190 cag gcg gtg gcg gcg gcg atg cag ccc ccg ctg gag gcg cct tac 13974 Gln Ala Val Ala Ala Ala Met Gln Pro Pro Leu Glu Ala Pro Tyr 1195 1200 1205 gtg ccc ccg cgg tac ctg gcg cct acg gag ggg cgg aac agc att 14019 Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg Asn Ser Ile 1210 1215 1220 cgt tac tcg gag ctg gca ccc ttg tac gat acc acc cgg ttg tac 14064 Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg Leu Tyr 1225 1230 1235 ctg gtg gac aac aag tcg gcg gac atc gcc tcg ctg aac tac cag 14109 Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr Gln 1240 1245 1250 aac gac cac agc aac ttc ctg acc acc gtg gtg cag aac aac gat 14154 Asn Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp 1255 1260 1265 ttc acc ccc acg gag gcc agc acc cag acc atc aac ttt gac gag 14199 Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu 1270 1275 1280 cgc tcg cgg tgg ggc ggc cag ctg aaa acc atc atg cac acc aac 14244 Arg Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn 1285 1290 1295 atg ccc aac gtg aac gag ttc atg tac agc aac aag ttc aag gcg 14289 Met Pro Asn Val Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala 1300 1305 1310 cgg gtg atg gtc tcg cgc aag acc ccc aac ggg gtc aca gta aca 14334 Arg Val Met Val Ser Arg Lys Thr Pro Asn Gly Val Thr Val Thr 1315 1320 1325 gat ggt agt cag gac gag ctg acc tac gag tgg gtg gag ttt gag 14379 Asp Gly Ser Gln Asp Glu Leu Thr Tyr Glu Trp Val Glu Phe Glu 1330 1335 1340 ctg ccc gag ggc aac ttc tcg gtg acc atg acc atc gat ctg atg 14424 Leu Pro Glu Gly Asn Phe Ser Val Thr Met Thr Ile Asp Leu Met 1345 1350 1355 aac aac gcc atc atc gac aac tac ttg gcg gtg gga cgg cag aac 14469 Asn Asn Ala Ile Ile Asp Asn Tyr Leu Ala Val Gly Arg Gln Asn 1360 1365 1370 ggg gtg ctg gag agc gac atc ggc gtg aag ttc gac acg cgc aac 14514 Gly Val Leu Glu Ser Asp Ile Gly Val Lys Phe Asp Thr Arg Asn 1375 1380 1385 ttc cgg ctg ggc tgg gac ccc gtg acc gag ctg gtg atg ccg ggc 14559 Phe Arg Leu Gly Trp Asp Pro Val Thr Glu Leu Val Met Pro Gly 1390 1395 1400 gtg tac acc aac gag gcc ttc cac ccc gac att gtc ctg ctg ccc 14604 Val Tyr Thr Asn Glu Ala Phe His Pro Asp Ile Val Leu Leu Pro 1405 1410 1415 ggc tgc ggc gtg gac ttc acc gag agc cgc ctc agc aac ctg ctg 14649 Gly Cys Gly Val Asp Phe Thr Glu Ser Arg Leu Ser Asn Leu Leu 1420 1425 1430 ggc atc cgc aag cgg cag ccc ttc cag gag ggc ttc cag atc ctg 14694 Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly Phe Gln Ile Leu 1435 1440 1445 tac gag gac ctg gag ggg ggc aac atc ccc gcg ctg ctg gac gtg 14739 Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp Val 1450 1455 1460 gac gcc tac gag aaa agc aag gag gag agc gcc gcc gcg gcg acc 14784 Asp Ala Tyr Glu Lys Ser Lys Glu Glu Ser Ala Ala Ala Ala Thr 1465 1470 1475 gca gcc gtg gcc acc gcc tct acc gag gtg cgg ggc gat aat ttt 14829 Ala Ala Val Ala Thr Ala Ser Thr Glu Val Arg Gly Asp Asn Phe 1480 1485 1490 gct agc gcc gcg gca gtg gcc gag gcg gct gaa acc gaa agt aag 14874 Ala Ser Ala Ala Ala Val Ala Glu Ala Ala Glu Thr Glu Ser Lys 1495 1500 1505 ata gtg atc cag ccg gtg gag aag gac agc aag gac agg agc tac 14919 Ile Val Ile Gln Pro Val Glu Lys Asp Ser Lys Asp Arg Ser Tyr 1510 1515 1520 aac gtg ctc gcg gac aag aaa aac acc gcc tac cgc agc tgg tac 14964 Asn Val Leu Ala Asp Lys Lys Asn Thr Ala Tyr Arg Ser Trp Tyr 1525 1530 1535 ctg gcc tac aac tac ggc gac ccc gag aag ggc gtg cgc tcc tgg 15009 Leu Ala Tyr Asn Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp 1540 1545 1550 acg ctg ctc acc acc tcg gac gtc acc tgc ggc gtg gag caa gtc 15054 Thr Leu Leu Thr Thr Ser Asp Val Thr Cys Gly Val Glu Gln Val 1555 1560 1565 tac tgg tcg ctg ccc gac atg atg caa gac ccg gtc acc ttc cgc 15099 Tyr Trp Ser Leu Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg 1570 1575 1580 tcc acg cga caa gtt agc aac tac ccg gtg gtg ggc gcc gag ctc 15144 Ser Thr Arg Gln Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu 1585 1590 1595 ctg ccc gtc tac tcc aag agc ttc ttc aac gag cag gcc gtc tac 15189 Leu Pro Val Tyr Ser Lys Ser Phe Phe Asn Glu Gln Ala Val Tyr 1600 1605 1610 tcg cag cag ctg cgc gcc ttc acc tcg ctc acg cac gtc ttc aac 15234 Ser Gln Gln Leu Arg Ala Phe Thr Ser Leu Thr His Val Phe Asn 1615 1620 1625 cgc ttc ccc gag aac cag atc ctc gtc cgc ccg ccc gcg ccc acc 15279 Arg Phe Pro Glu Asn Gln Ile Leu Val Arg Pro Pro Ala Pro Thr 1630 1635 1640 att acc acc gtc agt gaa aac gtt cct gct ctc aca gat cac ggg 15324 Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly 1645 1650 1655 acc ctg ccg ctg cgc agc agt atc cgg gga gtc cag cgc gtg acc 15369 Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val Thr 1660 1665 1670 gtc act gac gcc aga cgc cgc acc tgc ccc tac gtc tac aag gcc 15414 Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala 1675 1680 1685 ctg ggc gta gtc gcg ccg cgc gtc ctc tcg agc cgc acc ttc 15456 Leu Gly Val Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 1690 1695 1700 taaaaaatgt ccattctcat ctcgcccagt aataacaccg gttggggcct gcgcgcgccc 15516 agcaagatgt acggaggcgc tcgccaacgc tccacgcaac accccgtgcg cgtgcgcggg 15576 cacttccgcg ctccctgggg cgccctcaag ggtcgcgtgc gctcgcgcac caccgtcgac 15636 gacgtgatcg accaggtggt ggccgacgcg cgcaactaca cgcccgccgc cgcgcccgcc 15696 tccaccgtgg acgccgtcat cgacagcgtg gtggccgacg cgcgccggta cgcccgcgcc 15756 aagagccggc ggcggcgcat cgcccggcgg caccggagca cccccgccat gcgcgcggcg 15816 cgagccttgc tgcgcagggc caggcgcacg ggacgcaggg ccatgctcag ggcggccaga 15876 cgcgcggcct ccggcagcag cagcgccggc aggacccgca gacgcgcggc cacggcggcg 15936 gcggcggcca tcgccagcat gtcccgcccg cggcgcggca acgtgtactg ggtgcgcgac 15996 gccgccaccg gtgtgcgcgt gcccgtgcgc acccgccccc ctcgcacttg aagatgctga 16056 cttcgcgatg ttgatgtgtc ccagcggcga ggagg atg tcc aag cgc aaa ttc 16109 Met Ser Lys Arg Lys Phe 1705 aag gaa gag atg ctc cag gtc atc gcg cct gag atc tac ggc ccc 16154 Lys Glu Glu Met Leu Gln Val Ile Ala Pro Glu Ile Tyr Gly Pro 1710 1715 1720 gcg gcg gcg gtg aag gag gaa aga aag ccc cgc aaa ctg aag cgg 16199 Ala Ala Ala Val Lys Glu Glu Arg Lys Pro Arg Lys Leu Lys Arg 1725 1730 1735 gtc aaa aag gac aaa aag gaa gaa gat gtg gac gat atg gtg gag 16244 Val Lys Lys Asp Lys Lys Glu Glu Asp Val Asp Asp Met Val Glu 1740 1745 1750 ttt gtg cgc gag ttc gcc ccc cgg cgg cgc gtg cag tgg cgc ggg 16289 Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp Arg Gly 1755 1760 1765 cgg aag gtg cgc ccg gtg ctg aga ccc ggc acc acg gtg gtc ttc 16334 Arg Lys Val Arg Pro Val Leu Arg Pro Gly Thr Thr Val Val Phe 1770 1775 1780 acg ccc gga gag cgc tct ggc acc gcc tcc aag cgc tcc tac gac 16379 Thr Pro Gly Glu Arg Ser Gly Thr Ala Ser Lys Arg Ser Tyr Asp 1785 1790 1795 gag gtg tac ggg gat gat gat att ctg gag cag gcg gcc gag cgc 16424 Glu Val Tyr Gly Asp Asp Asp Ile Leu Glu Gln Ala Ala Glu Arg 1800 1805 1810 ctg ggc gag ttt gct tac ggc aag cgc agc cgc ccc gcg ccc ttg 16469 Leu Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Pro Ala Pro Leu 1815 1820 1825 aaa gag gag gcg gtg tcc atc ccg ctg gac cac ggc aac ccc acg 16514 Lys Glu Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr 1830 1835 1840 ccg agc ctg aag ccg gtg acc ctg cag cag gtg ctg cca gcc gcg 16559 Pro Ser Leu Lys Pro Val Thr Leu Gln Gln Val Leu Pro Ala Ala 1845 1850 1855 gcg ccg cgc cgg ggg ttc aag cgc gag ggc gag gat ctg tac ccc 16604 Ala Pro Arg Arg Gly Phe Lys Arg Glu Gly Glu Asp Leu Tyr Pro 1860 1865 1870 acc atg cag ctg atg gtg ccc aag cgc cag aag ctg gag gac gtg 16649 Thr Met Gln Leu Met Val Pro Lys Arg Gln Lys Leu Glu Asp Val 1875 1880 1885 ctg gag cac atg aag gtg gac ccg gac gtg cag ccc gag gtc aag 16694 Leu Glu His Met Lys Val Asp Pro Asp Val Gln Pro Glu Val Lys 1890 1895 1900 gtg cgg ccc atc aag cag gtg gcc ccg ggc ctg ggc gtg cag acc 16739 Val Arg Pro Ile Lys Gln Val Ala Pro Gly Leu Gly Val Gln Thr 1905 1910 1915 gtg gac atc aag atc ccc acg gag ccc atg gaa acg cag act gag 16784 Val Asp Ile Lys Ile Pro Thr Glu Pro Met Glu Thr Gln Thr Glu 1920 1925 1930 ccc gtg aag ccc agc acc agc acc atg gag gtg cag acg gat ccc 16829 Pro Val Lys Pro Ser Thr Ser Thr Met Glu Val Gln Thr Asp Pro 1935 1940 1945 tgg atg cca gcg gct tcc acc acc act cgc cga aga cgc aag tac 16874 Trp Met Pro Ala Ala Ser Thr Thr Thr Arg Arg Arg Arg Lys Tyr 1950 1955 1960 ggc gcg gcc agc ctg ctg atg ccc aac tac gcg ctg cat cct tcc 16919 Gly Ala Ala Ser Leu Leu Met Pro Asn Tyr Ala Leu His Pro Ser 1965 1970 1975 atc atc ccc acg ccg ggc tac cgc ggc acg cgc ttc tac cgc ggc 16964 Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg Phe Tyr Arg Gly 1980 1985 1990 tac acc agc agc cgc cgc cgc aag acc acc acc cgc cgc cgc cgt 17009 Tyr Thr Ser Ser Arg Arg Arg Lys Thr Thr Thr Arg Arg Arg Arg 1995 2000 2005 cgt cgc agc cgc cgc agc agc acc gcg act tcc gcc ttg gtg cgg 17054 Arg Arg Ser Arg Arg Ser Ser Thr Ala Thr Ser Ala Leu Val Arg 2010 2015 2020 aga gtg tac cgc agc ggg cgc gag cct ctg acc ctg ccg cgc gcg 17099 Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu Thr Leu Pro Arg Ala 2025 2030 2035 cgc tac cac ccg agc atc gcc att taactaccgc ctcctacttg cagat atg 17151 Arg Tyr His Pro Ser Ile Ala Ile Met 2040 2045 gcc ctc aca tgc cgc ctc cgc gtc ccc att acg ggc tac cga gga 17196 Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 2050 2055 2060 aga aag ccg cgc cgt aga agg ctg acg ggg aac ggg ctg cgt cgc 17241 Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly Asn Gly Leu Arg Arg 2065 2070 2075 cat cac cac cgg cgg cgg cgc gcc atc agc aag cgg ttg ggg gga 17286 His His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly 2080 2085 2090 ggc ttc ctg ccc gcg ctg atc ccc atc atc gcc gcg gcg atc ggg 17331 Gly Phe Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly 2095 2100 2105 gcg atc ccc ggc ata gct tcc gtg gcg gtg cag gcc tct cag cgc 17376 Ala Ile Pro Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg 2110 2115 2120 cac tgagacacag cttggaaaat ttgtaataaa aaatggactg acgctcctgg 17429 His tcctgtgatg tgtgttttta g atg gaa gac atc aat ttt tcg tcc ctg gca 17480 Met Glu Asp Ile Asn Phe Ser Ser Leu Ala 2125 2130 ccg cga cac ggc acg cgg ccg ttt atg ggc acc tgg agc gac atc 17525 Pro Arg His Gly Thr Arg Pro Phe Met Gly Thr Trp Ser Asp Ile 2135 2140 2145 ggc aac agc caa ctg aac ggg ggc gcc ttc aat tgg agc agt ctc 17570 Gly Asn Ser Gln Leu Asn Gly Gly Ala Phe Asn Trp Ser Ser Leu 2150 2155 2160 tgg agc ggg ctt aag aat ttc ggg tcc acg ctc aaa acc tat ggc 17615 Trp Ser Gly Leu Lys Asn Phe Gly Ser Thr Leu Lys Thr Tyr Gly 2165 2170 2175 aac aag gcg tgg aac agc agc aca ggg cag gcg ctg agg gaa aag 17660 Asn Lys Ala Trp Asn Ser Ser Thr Gly Gln Ala Leu Arg Glu Lys 2180 2185 2190 ctg aaa gag cag aac ttc cag cag aag gtg gtc gat ggc ctg gcc 17705 Leu Lys Glu Gln Asn Phe Gln Gln Lys Val Val Asp Gly Leu Ala 2195 2200 2205 tcg ggc atc aac ggg gtg gtg gac ctg gcc aac cag gcc gtg cag 17750 Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn Gln Ala Val Gln 2210 2215 2220 aaa cag atc aac agc cgc ctg gac gcg gtc ccg ccc gcg ggg tcc 17795 Lys Gln Ile Asn Ser Arg Leu Asp Ala Val Pro Pro Ala Gly Ser 2225 2230 2235 gtg gac atg ccc cag gtg gag gag gag ctg cct ccc ctg gac aag 17840 Val Asp Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu Asp Lys 2240 2245 2250 cgc ggc gac aag cga ccg cgt ccc gac gct gag gag acg ctg ctg 17885 Arg Gly Asp Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu Leu 2255 2260 2265 acg cac acg gac gag ccg ccc ccg tac gag gag gcg gtg aaa ctg 17930 Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu 2270 2275 2280 ggt ctg ccc acc acg cgg ccc gtg gcg cct ctg gcc acc ggg gtg 17975 Gly Leu Pro Thr Thr Arg Pro Val Ala Pro Leu Ala Thr Gly Val 2285 2290 2295 ctg aaa ccc agc agc agc agc agc cag ccc gcg acc ctg gac ttg 18020 Leu Lys Pro Ser Ser Ser Ser Ser Gln Pro Ala Thr Leu Asp Leu 2300 2305 2310 cct cca cct cgc ccc tcc aca gtg gct aag ccc ctg ccg ccg gtg 18065 Pro Pro Pro Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val 2315 2320 2325 gcc gtc gcg tcg cgc gcc ccc cga ggc cgc ccc cag gcg aac tgg 18110 Ala Val Ala Ser Arg Ala Pro Arg Gly Arg Pro Gln Ala Asn Trp 2330 2335 2340 cag agc act ctg aac agc atc gtg ggt ctg gga gtg cag agt gtg 18155 Gln Ser Thr Leu Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val 2345 2350 2355 aag cgc cgc cgc tgc tat taaaagacac tgtagcgctt aacttgcttg 18203 Lys Arg Arg Arg Cys Tyr 2360 tctgtgtgtg tat atg tat gtc cgc cga cca gaa gga gga aga ggc gcg 18252 Met Tyr Val Arg Arg Pro Glu Gly Gly Arg Gly Ala 2365 2370 tcg ccg agt tgc aag atg gcc acc cca tcg atg ctg ccc cag tgg 18297 Ser Pro Ser Cys Lys Met Ala Thr Pro Ser Met Leu Pro Gln Trp 2375 2380 2385 gcg tac atg cac atc gcc gga cag gac gct tcg gag tac ctg agt 18342 Ala Tyr Met His Ile Ala Gly Gln Asp Ala Ser Glu Tyr Leu Ser 2390 2395 2400 ccg ggt ctg gtg cag ttc gcc cgc gcc aca gac acc tac ttc agt 18387 Pro Gly Leu Val Gln Phe Ala Arg Ala Thr Asp Thr Tyr Phe Ser 2405 2410 2415 ctg ggg aac aag ttt agg aac ccc acg gtg gcg ccc acg cac gat 18432 Leu Gly Asn Lys Phe Arg Asn Pro Thr Val Ala Pro Thr His Asp 2420 2425 2430 gtg acc acc gac cgc agc cag cgg ctg acg ctg cgc ttc gtg ccc 18477 Val Thr Thr Asp Arg Ser Gln Arg Leu Thr Leu Arg Phe Val Pro 2435 2440 2445 gtg gac cgc gag gac aac acc tac tcg tac aaa gtg cgc tac acg 18522 Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr Lys Val Arg Tyr Thr 2450 2455 2460 ctg gcc gtg ggc gac aac cgc gtg ctg gac atg gcc agc acc tac 18567 Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met Ala Ser Thr Tyr 2465 2470 2475 ttt gac atc cgc ggc gtg ctg gat cgg ggc ccc agc ttc aaa ccc 18612 Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser Phe Lys Pro 2480 2485 2490 tac tcc ggc acc gcc tac aac agc ctg gct ccc aag gga gcg ccc 18657 Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly Ala Pro 2495 2500 2505 aac acc tca caa tgg ata acc aaa gac aag aca tac agt ttt gga 18702 Asn Thr Ser Gln Trp Ile Thr Lys Asp Lys Thr Tyr Ser Phe Gly 2510 2515 2520 aat gct cca gtc aga gga ttg gac att aca gaa gag ggt ctc caa 18747 Asn Ala Pro Val Arg Gly Leu Asp Ile Thr Glu Glu Gly Leu Gln 2525 2530 2535 ata gta acc gat gag tca ggg ggt gaa agc aag aaa att ttt gca 18792 Ile Val Thr Asp Glu Ser Gly Gly Glu Ser Lys Lys Ile Phe Ala 2540 2545 2550 gac aaa acc tat cag cct gaa cct cag ctt gga gat gag gaa tgg 18837 Asp Lys Thr Tyr Gln Pro Glu Pro Gln Leu Gly Asp Glu Glu Trp 2555 2560 2565 cat gat act att gga gct gaa gac aag tat gga ggc aga gcg ctt 18882 His Asp Thr Ile Gly Ala Glu Asp Lys Tyr Gly Gly Arg Ala Leu 2570 2575 2580 aaa cct gcc acc aac atg aaa ccc tgc tat ggg tct ttc gcc aag 18927 Lys Pro Ala Thr Asn Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys 2585 2590 2595 cca act aat gct aag gga ggt cag gct aaa agc aga acc aag gac 18972 Pro Thr Asn Ala Lys Gly Gly Gln Ala Lys Ser Arg Thr Lys Asp 2600 2605 2610 gat ggc act act gag cct gat att gac atg gcc ttt ttt gac gat 19017 Asp Gly Thr Thr Glu Pro Asp Ile Asp Met Ala Phe Phe Asp Asp 2615 2620 2625 cgc agt cag caa gct agt ttc agt cca gaa ctt gtt ttg tat act 19062 Arg Ser Gln Gln Ala Ser Phe Ser Pro Glu Leu Val Leu Tyr Thr 2630 2635 2640 gag aat gtc gat ctg gac acc ccg gat acc cac att att tac aaa 19107 Glu Asn Val Asp Leu Asp Thr Pro Asp Thr His Ile Ile Tyr Lys 2645 2650 2655 cct ggc act gat gaa aca agt tct tct ttc aac ttg ggt cag cag 19152 Pro Gly Thr Asp Glu Thr Ser Ser Ser Phe Asn Leu Gly Gln Gln 2660 2665 2670 tcc atg ccc aac aga ccc aat tac att ggc ttc aga gac aac ttt 19197 Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe 2675 2680 2685 atc gga ctc atg tac tac aac agc act ggc aat atg ggt gta ctg 19242 Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu 2690 2695 2700 gct gga cag gcc tcc cag ctg aat gct gtg gtg gac ttg cag gac 19287 Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp 2705 2710 2715 aga aac acc gaa ctg tcc tac cag ctc ttg ctt gac tct ctg ggc 19332 Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly 2720 2725 2730 gac aga acc agg tat ttc agt atg tgg aat cag gcg gtg gac agc 19377 Asp Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser 2735 2740 2745 tat gac ccc gat gtg cgc att att gaa aat cac ggt gtg gag gat 19422 Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp 2750 2755 2760 gaa ctt ccc aac tat tgc ttc cct ttg aat ggt gtg ggc ttt aca 19467 Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asn Gly Val Gly Phe Thr 2765 2770 2775 gat tca ttc cag gga att aag gtt aaa act acc aat aac gga aca 19512 Asp Ser Phe Gln Gly Ile Lys Val Lys Thr Thr Asn Asn Gly Thr 2780 2785 2790 gca aac gct aca gag tgg gaa tct gat acc tct gtc aat aat gct 19557 Ala Asn Ala Thr Glu Trp Glu Ser Asp Thr Ser Val Asn Asn Ala 2795 2800 2805 aat gag att gcc aag ggc aat cct ttc gcc atg gag atc aac atc 19602 Asn Glu Ile Ala Lys Gly Asn Pro Phe Ala Met Glu Ile Asn Ile 2810 2815 2820 cag gcc aac ctg tgg cgg aac ttc ctc tac gcg aac gtg gcg ctg 19647 Gln Ala Asn Leu Trp Arg Asn Phe Leu Tyr Ala Asn Val Ala Leu 2825 2830 2835 tac ctg ccc gac tcc tac aag tac acg ccg gcc aac atc acg ctg 19692 Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr Pro Ala Asn Ile Thr Leu 2840 2845 2850 ccc acc aac acc aac acc tac gat tac atg aac ggc cgc gtg gtg 19737 Pro Thr Asn Thr Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val Val 2855 2860 2865 gcg ccc tcg ctg gtg gac gcc tac atc aac atc ggg gcg cgc tgg 19782 Ala Pro Ser Leu Val Asp Ala Tyr Ile Asn Ile Gly Ala Arg Trp 2870 2875 2880 tcg ctg gac ccc atg gac aac gtc aac ccc ttc aac cac cac cgc 19827 Ser Leu Asp Pro Met Asp Asn Val Asn Pro Phe Asn His His Arg 2885 2890 2895 aac gcg ggc ctg cga tac cgc tcc atg ctc ctg ggc aac ggg cgc 19872 Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg 2900 2905 2910 tac gtg ccc ttc cac atc cag gtg ccc caa aag ttt ttc gcc atc 19917 Tyr Val Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile 2915 2920 2925 aag agc ctc ctg ctc ctg ccc ggg tcc tac acc tac gag tgg aac 19962 Lys Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn 2930 2935 2940 ttc cgc aag gac gtc aac atg atc ctg cag agc tcc ctc ggc aac 20007 Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn 2945 2950 2955 gac ctg cgc acg gac ggg gcc tcc atc tcc ttc acc agc atc aac 20052 Asp Leu Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn 2960 2965 2970 ctc tac gcc acc ttc ttc ccc atg gcg cac aac acg gcc tcc acg 20097 Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr 2975 2980 2985 ctc gag gcc atg ctg cgc aac gac acc aac gac cag tcc ttc aac 20142 Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn 2990 2995 3000 gac tac ctc tcg gcg gcc aac atg ctc tac ccc atc ccg gcc aac 20187 Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn 3005 3010 3015 gcc acc aac gtg ccc atc tcc atc ccc tcg cgc aac tgg gcc gcc 20232 Ala Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala 3020 3025 3030 ttc cgc ggc tgg tcc ttc acg cgt ctc aag acc aag gag acg ccc 20277 Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro 3035 3040 3045 tcg ctg ggc tcc ggg ttc gac ccc tac ttc gtc tac tcg ggc tcc 20322 Ser Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser 3050 3055 3060 atc ccc tac ctc gac ggc acc ttc tac ctc aac cac acc ttc aag 20367 Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys 3065 3070 3075 aag gtc tcc atc acc ttc gac tcc tcc gtc agc tgg ccc ggc aac 20412 Lys Val Ser Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn 3080 3085 3090 gac cgc ctc ctg acg ccc aac gag ttc gaa atc aag cgc acc gtc 20457 Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val 3095 3100 3105 gac gga gag ggg tac aac gtg gcc cag tgc aac atg acc aag gac 20502 Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp 3110 3115 3120 tgg ttc ctg gtc cag atg ctg gcc cac tac aac atc ggc tac cag 20547 Trp Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln 3125 3130 3135 ggc ttc tac gtg ccc gag ggc tac aag gac cgc atg tac tcc ttc 20592 Gly Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe 3140 3145 3150 ttc cgc aac ttc cag ccc atg agc cgc cag gtc gtg gac gag gtc 20637 Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Val 3155 3160 3165 aac tac aag gac tac cag gcc gtc acc ctg gcc tac cag cac aac 20682 Asn Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn 3170 3175 3180 aac tcg ggc ttc gtc ggc tac ctc gcg ccc acc atg cgc cag ggg 20727 Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly 3185 3190 3195 cag ccc tac ccc gcc aac tac ccg tac ccg ctc atc ggc aag agc 20772 Gln Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser 3200 3205 3210 gcc gtc acc agc gtc acc cag aaa aag ttc ctc tgc gac cgg gtc 20817 Ala Val Thr Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val 3215 3220 3225 atg tgg cgc atc ccc ttc tcc agc aac ttc atg tcc atg ggc gcg 20862 Met Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala 3230 3235 3240 ctc acc gac ctc ggc cag aac atg ctc tat gcc aac tcc gcc cac 20907 Leu Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His 3245 3250 3255 gcg cta gac atg aat ttc gaa gtc gac ccc atg gat gag tcc acc 20952 Ala Leu Asp Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr 3260 3265 3270 ctt ctc tat gtt gtc ttc gaa gtc ttc gac gtc gtc cga gtg cac 20997 Leu Leu Tyr Val Val Phe Glu Val Phe Asp Val Val Arg Val His 3275 3280 3285 cag ccc cac cgc ggc gtc atc gag gcc gtc tac ctg cgc acc ccc 21042 Gln Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro 3290 3295 3300 ttc tcg gcc ggt aac gcc acc acc taagctcttg cttcttgc atg atg 21090 Phe Ser Ala Gly Asn Ala Thr Thr Met Met 3305 3310 gct gag ccc acg ggc tcc ggc gag cag gag ctc agg gcc atc atc 21135 Ala Glu Pro Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile 3315 3320 3325 cgc gac ctg ggc tgc ggg ccc tac ttc ctg ggc acc ttc gat aag 21180 Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys 3330 3335 3340 cgc ttc ccg gga ttc atg gcc ccg cac aag ctg gcc tgc gcc atc 21225 Arg Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile 3345 3350 3355 gtc aac acg gcc ggt cgc gag acc ggg ggc gag cac tgg ctg gcc 21270 Val Asn Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala 3360 3365 3370 ttc gcc tgg aac ccg cgc tcg aac acc tgc tac ctc ttc gac ccc 21315 Phe Ala Trp Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro 3375 3380 3385 ttc ggg ttc tcg gac gag cgc ctc aag cag atc tac cag ttc gag 21360 Phe Gly Phe Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu 3390 3395 3400 tac gag ggc ctg ctg cgc cgc agc gcc ctg gcc acc gag gac cgc 21405 Tyr Glu Gly Leu Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg 3405 3410 3415 tgc gtc acc ctg gaa aag tcc acc cag acc gtg cag ggt ccg cgc 21450 Cys Val Thr Leu Glu Lys Ser Thr Gln Thr Val Gln Gly Pro Arg 3420 3425 3430 tcg gcc gcc tgc ggg ctc ttc tgc tgc atg ttc ctg cac gcc ttc 21495 Ser Ala Ala Cys Gly Leu Phe Cys Cys Met Phe Leu His Ala Phe 3435 3440 3445 gtg cac tgg ccc gac cgc ccc atg gac aag aac ccc acc atg aac 21540 Val His Trp Pro Asp Arg Pro Met Asp Lys Asn Pro Thr Met Asn 3450 3455 3460 ttg ctg acg ggg gtg ccc aac ggc atg ctc cag tcg ccc cag gtg 21585 Leu Leu Thr Gly Val Pro Asn Gly Met Leu Gln Ser Pro Gln Val 3465 3470 3475 gaa ccc acc ctg cgc cgc aac cag gag gcg ctc tac cgc ttc ctc 21630 Glu Pro Thr Leu Arg Arg Asn Gln Glu Ala Leu Tyr Arg Phe Leu 3480 3485 3490 aac gcc cac tcc gcc tac ttt cgc tcc cac cgc gcg cgc atc gag 21675 Asn Ala His Ser Ala Tyr Phe Arg Ser His Arg Ala Arg Ile Glu 3495 3500 3505 aag gcc acc gcc ttc gac cgc atg aat caa gac atg taaaccgtgt 21721 Lys Ala Thr Ala Phe Asp Arg Met Asn Gln Asp Met 3510 3515 3520 gtgtatgtga atgctttatt cataataaac agcacatgtt tatgccacct tctctgaggc 21781 tctgacttta tttagaaatc gaaggggttc tgccggctct cggcgtgccc cgcgggcagg 21841 gatacgttgc ggaactggta cttgggcagc cacttgaact cggggatcag cagcttcggc 21901 acggggaggt cggggaacga gtcgctccac agcttgcgcg tgagttgcag ggcgcccagc 21961 aggtcgggcg cggagatctt gaaatcgcag ttgggacccg cgttctgcgc gcgagagttg 22021 cggtacacgg ggttgcagca ctggaacacc atcagggccg ggtgcttcac gctcgccagc 22081 accgtcgcgt cggtgatgcc ctccacgtcc agatcctcgg cgttggccat cccgaagggg 22141 gtcatcttgc aggtctgccg ccccatgctg ggcacgcagc cgggcttgtg gttgcaatcg 22201 cagtgcaggg ggatcagcat catctgggcc tgctcggagc tcatgcccgg gtacatggcc 22261 ttcatgaaag cctccagctg gcggaaggcc tgctgcgcct tgccgccctc ggtgaagaag 22321 accccgcagg acttgctaga gaactggttg gtagcgcagc ccgcgtcgtg cacgcagcag 22381 cgcgcgtcgt tgttggccag ctgcaccacg ctgcgccccc agcggttctg ggtgatcttg 22441 gcccggtcgg ggttctcctt cagcgcgcgc tgcccgttct cgctcgccac atccatctcg 22501 atcgtgtgct ccttctggat catcacggtc ccgtgcaggc accgcagctt gccctcggcc 22561 tcggtgcagc cgtgcagcca cagcgcgcag ccggtgctct cccagttctt gtgggcgatc 22621 tgggagtgcg agtgcacgaa gccctgcagg aagcggccca tcatcgcggt cagggtcttg 22681 ttgctggtga aggtcagcgg gatgccgcgg tgctcctcgt tcacatacag gtggcagatg 22741 cggcggtaca cctcgccctg ctcgggcatc agctggaagg cggacttcag gtcgctctcc 22801 acgcggtacc gctccatcag cagcgtcatc acttccatgc ccttctccca ggccgaaacg 22861 atcggcaggc tcagggggtt cttcaccgtc atcttagtcg ccgccgccga ggtcaggggg 22921 tcgttctcgt ccagggtctc aaacactcgc ttgccgtcct tctcggtgat gcgcacgggg 22981 gggaaggcga agcccacggc cgccagctcc tcctcggcct gcctttcgtc ctcgctgtcc 23041 tggctgatgt cttgcaaagg cacatgcttg gtcttgcggg gtttcttttt gggcggcaga 23101 ggcggcggcg gagacgtgct gggcgagcgc gagttctcgc tcaccacgac tatttcttct 23161 tcttggccgt cgtccgagac cacgcggcgg taggcatgcc tcttctgggg cagaggcgga 23221 ggcgacgggc tctcgcggtt cgacgggcgg ctggcagagc cccttccgcg ttcgggggtg 23281 cgctcctggc ggcgctgctc tgactgactt cctccgcggc cggccattgt gttctcctag 23341 ggagcaacaa gc atg gag act cag cca tcg tcg cca aca tcg cca tct 23389 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser 3525 3530 gcc ccc gcc gcc gcc gac gag aac cag cag cag cag aat gaa agc 23434 Ala Pro Ala Ala Ala Asp Glu Asn Gln Gln Gln Gln Asn Glu Ser 3535 3540 3545 tta acc gcc ccg ccg ccc agc ccc acc tcc gac gcc gcc gca gcc 23479 Leu Thr Ala Pro Pro Pro Ser Pro Thr Ser Asp Ala Ala Ala Ala 3550 3555 3560 cca gac atg caa gag atg gag gaa tcc atc gag att gac ctg ggc 23524 Pro Asp Met Gln Glu Met Glu Glu Ser Ile Glu Ile Asp Leu Gly 3565 3570 3575 tac gtg acg ccc gcg gag cac gag gag gag ctg gca gcg cgc ttt 23569 Tyr Val Thr Pro Ala Glu His Glu Glu Glu Leu Ala Ala Arg Phe 3580 3585 3590 tca gcc ccg gaa gag aac cac caa gag cag cca gag cag gaa gca 23614 Ser Ala Pro Glu Glu Asn His Gln Glu Gln Pro Glu Gln Glu Ala 3595 3600 3605 gag agc gag cag cag cag gct ggg ctc gag cat ggc gac tac ctg 23659 Glu Ser Glu Gln Gln Gln Ala Gly Leu Glu His Gly Asp Tyr Leu 3610 3615 3620 agc ggg gca gag gac gtg ctc atc aag cat ctg gcc cgc caa tgc 23704 Ser Gly Ala Glu Asp Val Leu Ile Lys His Leu Ala Arg Gln Cys 3625 3630 3635 atc atc gtc aag gac gcg ctg ctc gac cgc gcc gag gtg ccc ctc 23749 Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Ala Glu Val Pro Leu 3640 3645 3650 agc gtg gcg gag ctc agc cgc gcc tac gag cgc aac ctc ttc tcg 23794 Ser Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg Asn Leu Phe Ser 3655 3660 3665 ccg cgc gtg ccc ccc aag cgc cag ccc aac ggc acc tgc gag ccc 23839 Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys Glu Pro 3670 3675 3680 aac ccg cgc ctc aac ttc tac ccg gtc ttc gcg gtg ccc gag gcc 23884 Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu Ala 3685 3690 3695 ctg gcc acc tac cac ctc ttt ttc aag aac caa agg atc ccc gtc 23929 Leu Ala Thr Tyr His Leu Phe Phe Lys Asn Gln Arg Ile Pro Val 3700 3705 3710 tcc tgc cgc gcc aac cgc acc cgc gcc gac gcc ctg ctc aac ctg 23974 Ser Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Leu Asn Leu 3715 3720 3725 ggc ccc ggc gcc cgc cta cct gat atc gcc tcc ttg gaa gag gtt 24019 Gly Pro Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val 3730 3735 3740 ccc aag atc ttc gag ggt ctg ggc agc gac gag act cgg gcc gcg 24064 Pro Lys Ile Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala 3745 3750 3755 aac gct ctg caa gga agc gga gag gag cat gag cac cac agc gcc 24109 Asn Ala Leu Gln Gly Ser Gly Glu Glu His Glu His His Ser Ala 3760 3765 3770 ctg gtg gag ttg gaa ggc gac aac gcg cgc ctg gcg gtc ctc aag 24154 Leu Val Glu Leu Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys 3775 3780 3785 cgc acg gtc gag ctg acc cac ttc gcc tac cca gcg ctc aac ctg 24199 Arg Thr Val Glu Leu Thr His Phe Ala Tyr Pro Ala Leu Asn Leu 3790 3795 3800 ccc ccc aag gtc atg agc gcc gtc atg gac cag gtg ctc atc aag 24244 Pro Pro Lys Val Met Ser Ala Val Met Asp Gln Val Leu Ile Lys 3805 3810 3815 cgc gcc tcg ccc ctc tcg gag gag gag atg cag gac ccc gag agc 24289 Arg Ala Ser Pro Leu Ser Glu Glu Glu Met Gln Asp Pro Glu Ser 3820 3825 3830 tcg gac gag ggc aag ccc gtg gtc agc gac gag cag ctg gcg cgc 24334 Ser Asp Glu Gly Lys Pro Val Val Ser Asp Glu Gln Leu Ala Arg 3835 3840 3845 tgg ctg gga gcg agt agc acc ccc cag agc ctg gaa gag cgg cgc 24379 Trp Leu Gly Ala Ser Ser Thr Pro Gln Ser Leu Glu Glu Arg Arg 3850 3855 3860 aag ctc atg atg gcc gtg gtc ctg gtg acc gtg gag ctg gag tgt 24424 Lys Leu Met Met Ala Val Val Leu Val Thr Val Glu Leu Glu Cys 3865 3870 3875 ctg cgc cgc ttc ttt gcc gac gcg gag acc ctg cgc aag gtc gag 24469 Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu Arg Lys Val Glu 3880 3885 3890 gag aac ctg cac tac ctc ttc agg cac ggg ttc gtg cgc cag gcc 24514 Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val Arg Gln Ala 3895 3900 3905 tgc aag atc tcc aac gtg gag ctg acc aac ctg gtc tcc tac atg 24559 Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr Met 3910 3915 3920 ggc atc ctg cac gag aac cgc ctg ggg cag aac gtg ctg cac acc 24604 Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr 3925 3930 3935 acc ctg cgc ggg gag gcc cgc cgc gac tac atc cgc gac tgc gtc 24649 Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val 3940 3945 3950 tac ctg tac ctc tgc cac acc tgg cag acg ggc atg ggc gtg tgg 24694 Tyr Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp 3955 3960 3965 cag cag tgc ctg gag gag cag aac ctg aaa gag ctc tgc aag ctc 24739 Gln Gln Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu 3970 3975 3980 ctg cag aag aac ctc aag gcc ctg tgg acc ggg ttc gac gag cgc 24784 Leu Gln Lys Asn Leu Lys Ala Leu Trp Thr Gly Phe Asp Glu Arg 3985 3990 3995 acc acc gcc tcg gac ctg gcc gac ctc atc ttc ccc gag cgc ctg 24829 Thr Thr Ala Ser Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu 4000 4005 4010 cgg ctg acg ctg cgc aac ggg ctg ccc gac ttt atg agc caa agc 24874 Arg Leu Thr Leu Arg Asn Gly Leu Pro Asp Phe Met Ser Gln Ser 4015 4020 4025 atg ttg caa aac ttt cgc tct ttc atc ctc gaa cgc tcc ggg atc 24919 Met Leu Gln Asn Phe Arg Ser Phe Ile Leu Glu Arg Ser Gly Ile 4030 4035 4040 ctg ccc gcc acc tgc tcc gca ctg ccc tcg gac ttc gtg ccg ctg 24964 Leu Pro Ala Thr Cys Ser Ala Leu Pro Ser Asp Phe Val Pro Leu 4045 4050 4055 acc ttc cgc gag tgc ccc ccg ccg ctc tgg agc cac tgc tac ctg 25009 Thr Phe Arg Glu Cys Pro Pro Pro Leu Trp Ser His Cys Tyr Leu 4060 4065 4070 ctg cgc ctg gcc aac tac ctg gcc tac cac tcg gac gtg atc gag 25054 Leu Arg Leu Ala Asn Tyr Leu Ala Tyr His Ser Asp Val Ile Glu 4075 4080 4085 gac gtc agc ggc gag ggt ctg ctc gag tgc cac tgc cgc tgc aac 25099 Asp Val Ser Gly Glu Gly Leu Leu Glu Cys His Cys Arg Cys Asn 4090 4095 4100 ctc tgc acg ccg cac cgc tcc ctg gcc tgc aac ccc cag ctg ctg 25144 Leu Cys Thr Pro His Arg Ser Leu Ala Cys Asn Pro Gln Leu Leu 4105 4110 4115 agc gag acc cag atc atc ggc acc ttc gag ttg caa ggg ccc ggt 25189 Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln Gly Pro Gly 4120 4125 4130 gac ggc aag ggg ggt ctg aaa ctc acc ccg ggg ctg tgg acc tcg 25234 Asp Gly Lys Gly Gly Leu Lys Leu Thr Pro Gly Leu Trp Thr Ser 4135 4140 4145 gcc tac ttg cgc aag ttc gtg ccc gag gac tac cat ccc ttc gag 25279 Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr His Pro Phe Glu 4150 4155 4160 atc agg ttc tac gag gac caa tcc cag ccg ccc aag gcc gag ctg 25324 Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys Ala Glu Leu 4165 4170 4175 tcg gcc tgc gtc atc acc cag ggg gcc atc ctg gcc caa ttg caa 25369 Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala Gln Leu Gln 4180 4185 4190 gcc atc cag aaa tcc cgc caa gaa ttt ctg ctg aaa aag ggc cac 25414 Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly His 4195 4200 4205 ggg gtc tac ctg gac ccc cag acc gga gag gag ctc aac ccc agc 25459 Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro Ser 4210 4215 4220 ttc ccc cag gat gcc ccg agg aag cag caa gaa gct gaa agt gga 25504 Phe Pro Gln Asp Ala Pro Arg Lys Gln Gln Glu Ala Glu Ser Gly 4225 4230 4235 gct gcc gcc gga gga ttt gga gga aga ctg gga gag cag tca ggc 25549 Ala Ala Ala Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Ser Gly 4240 4245 4250 aga gga gat gga aga ctg gga cag cac tca ggc aga gga gga cag 25594 Arg Gly Asp Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln 4255 4260 4265 cct gca aga cag tct gga aga cga ggt gga gga gga ggc aga gga 25639 Pro Ala Arg Gln Ser Gly Arg Arg Gly Gly Gly Gly Gly Arg Gly 4270 4275 4280 aga agc agc cgc cgc cag acc gtc gtc ctc ggc gga gga gga gaa 25684 Arg Ser Ser Arg Arg Gln Thr Val Val Leu Gly Gly Gly Gly Glu 4285 4290 4295 agc aag cag cac gga tac cat ctc cgc tcc ggg tcr ggg tcg cgg 25729 Ser Lys Gln His Gly Tyr His Leu Arg Ser Gly Xaa Gly Ser Arg 4300 4305 4310 cgg ccg ggc cca cag taggtgggac gagaccgggc gcttcccgaa ccccaccacc 25784 Arg Pro Gly Pro Gln 4315 cagaccggta agaaggagcg gcagggatac aagtcctggc gggggcacaa aaacgccatc 25844 gtctcctgct tgcaagcctg cgggggcaac atctccttca cccggcgcta cctgctcttc 25904 caccgcgggg tgaacttccc ccgcaacatc ttgcattact accgtcacct ccacagcccc 25964 tactactgtt tccaagaaga ggcagaaacc cagcagcagc agaaaaccag cggcagctag 26024 aaaatccaca gcggcggcgg caggtggact gaggatcgcg gcgaacgagc cggcgcagac 26084 ccgggagctg aggaaccgga tctttcccac cctctatgcc atcttccagc agagtcgggg 26144 gcaggagcag gaactgaaag tcaagaaccg ttctctgcgc tcgctcaccc gcagttgtct 26204 gtatcacaag agcgaagacc aacttcagcg cactctcgag gacgccgagg ctctcttcaa 26264 caagtactgc gcgctcactc ttaaagagta gcccgcgccc gcccacacac ggaaaaaggc 26324 gggaattacg tcaccacctg cgcccttcgc ccgaccatca tc atg agc aaa gag 26378 Met Ser Lys Glu 4320 att ccc acg cct tac atg tgg agc tac cag ccc cag atg ggc ctg 26423 Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln Met Gly Leu 4325 4330 4335 gcc gcc ggc gcc gcc cag gac tac tcc acc cgc atg aac tgg ctc 26468 Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn Trp Leu 4340 4345 4350 agt gcc ggg ccc gcg atg atc tca cgg gtg aat gac atc cgc gcc 26513 Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg Ala 4355 4360 4365 cac cga aac cag ata ctc cta gaa cag tca gcg atc acc gcc acg 26558 His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr 4370 4375 4380 ccc cgc cat cac ctt aat ccg cgt aat tgg ccc gcc gcc ctg gtg 26603 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val 4385 4390 4395 tac cag gaa att ccc cag ccc acg acc gta cta ctt ccg cga gac 26648 Tyr Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp 4400 4405 4410 gcc cag gcc gaa gtc cag ctg act aac tca ggt gtc cag ctg gcc 26693 Ala Gln Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala 4415 4420 4425 ggc ggc gcc acc ctg tgt cgt cac cgc ccc gct cag ggt ata aag 26738 Gly Gly Ala Thr Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys 4430 4435 4440 cgg ctg gtg atc cga ggc aga ggc aca cag ctc aac gac gag gtg 26783 Arg Leu Val Ile Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val 4445 4450 4455 gtg agc tct tcg ctg ggt ctg cga cct gac gga gtc ttc caa ctc 26828 Val Ser Ser Ser Leu Gly Leu Arg Pro Asp Gly Val Phe Gln Leu 4460 4465 4470 gcc gga tcg ggg aga tct tcc ttc acg cct cgt cag gcc gtc ctg 26873 Ala Gly Ser Gly Arg Ser Ser Phe Thr Pro Arg Gln Ala Val Leu 4475 4480 4485 act ttg gag agt tcg tcc tca cag ccc cgc tcg ggc ggc atc ggc 26918 Thr Leu Glu Ser Ser Ser Ser Gln Pro Arg Ser Gly Gly Ile Gly 4490 4495 4500 act ctc cag ttc gtg gag gag ttc act ccc tcg gtc tac ttc aac 26963 Thr Leu Gln Phe Val Glu Glu Phe Thr Pro Ser Val Tyr Phe Asn 4505 4510 4515 ccc ttc tcc ggc tcc ccc ggc cac tac ccg gac gag ttc atc ccg 27008 Pro Phe Ser Gly Ser Pro Gly His Tyr Pro Asp Glu Phe Ile Pro 4520 4525 4530 aac ttc gac gcc atc agc gag tcg gtg gac ggc tac gat tga atg 27053 Asn Phe Asp Ala Ile Ser Glu Ser Val Asp Gly Tyr Asp Met 4535 4540 4545 tcc cat ggt ggc gtg gct gac cta gct cgg ctt cga cac ctg gac 27098 Ser His Gly Gly Val Ala Asp Leu Ala Arg Leu Arg His Leu Asp 4550 4555 4560 cac tgc cgc cgc ttc cgc tgc ttc gct cgg gat ctc gcc gag ttt 27143 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe 4565 4570 4575 gcc tac ttt gag ctg ccc gag gag cac cct cag ggc ccg gcc cac 27188 Ala Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His 4580 4585 4590 gga gtg cgg atc atc gtc gaa ggg ggt ctc gac tcc cac ctg ctt 27233 Gly Val Arg Ile Ile Val Glu Gly Gly Leu Asp Ser His Leu Leu 4595 4600 4605 cgg atc ttc agc cag cga ccg atc ctg gtc gag cgc gag caa gga 27278 Arg Ile Phe Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln Gly 4610 4615 4620 cag acc cgt ctg acc ctg tac tgc atc tgc aac cac ccc ggc ctg 27323 Gln Thr Arg Leu Thr Leu Tyr Cys Ile Cys Asn His Pro Gly Leu 4625 4630 4635 cat gaa agt ctt tgt tgt ctg ctg tgt act gag tat aat aaa agc 27368 His Glu Ser Leu Cys Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 4640 4645 4650 tgagatcagc gactactccg gactcgattg tggtgttcct gctatcaacc agtccctgtt 27428 cttcaccggg aacgagaccg agctccagct ccagtgtaag ccccacaaga agtatctcac 27488 ctggctgttc cagggctccc cgatcgccgt tgtcaaccac tgcgacaacg acggagtcct 27548 gctgagcggc cctgccaacc ttactttttc cacccgcaga agcaagctcc agctcttcca 27608 acccttcctc cccgggacct atcagtgcgt ctcgggaccc tgccatcaca ccttccacct 27668 gatcccgaat accacagcgc cgctccccgc tactaacaac caaactaccc accaacgcca 27728 ccgtcgcgac ctttcctctg aatctaatac cactaccgga ggtgagctcc gaggtcgacc 27788 aacctctggg atttactacg gcccctggga ggtggtgggg ttaatagcgc taggcctagt 27848 tgtgggtggg cttttggctc tctgctacct atacctccct tgctgttcgt acttagtggt 27908 gctgtgttgc tggtttaaga a atg ggg cag atc acc cta gtg agc tgc ggt 27959 Met Gly Gln Ile Thr Leu Val Ser Cys Gly 4655 4660 gtg ctg gtg gcg gtg ctt tcg att gtg gga ctg ggc ggc gcg gct 28004 Val Leu Val Ala Val Leu Ser Ile Val Gly Leu Gly Gly Ala Ala 4665 4670 4675 gta gtg aag gag gag aag gcc gat ccc tgc ttg cat ttc aat ccc 28049 Val Val Lys Glu Glu Lys Ala Asp Pro Cys Leu His Phe Asn Pro 4680 4685 4690 gac aaa tgc cag ctg agt ttt cag ccc gat ggc aat cgg tgc gcg 28094 Asp Lys Cys Gln Leu Ser Phe Gln Pro Asp Gly Asn Arg Cys Ala 4695 4700 4705 gtg ctg atc aag tgc gga tgg gaa tgc gag aac gtg aga atc gag 28139 Val Leu Ile Lys Cys Gly Trp Glu Cys Glu Asn Val Arg Ile Glu 4710 4715 4720 tac aat aac aag act cgg aac aat act ctc gcg tcc gtg tgg cag 28184 Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu Ala Ser Val Trp Gln 4725 4730 4735 ccc ggg gac ccc gag tgg tac acc gtc tct gtc ccc ggt gct gac 28229 Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val Pro Gly Ala Asp 4740 4745 4750 ggc tcc ccg cgc acc gtg aac aat act ttc att ttt gcg cac atg 28274 Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe Ala His Met 4755 4760 4765 tgc gac acg gtc atg tgg atg agc aag cag tac gat atg tgg ccc 28319 Cys Asp Thr Val Met Trp Met Ser Lys Gln Tyr Asp Met Trp Pro 4770 4775 4780 ccc acg aag gag aac atc gtg gtc ttc tcc atc gct tac agc ctg 28364 Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser Leu 4785 4790 4795 tgc acg gtg cta atc acc gct atc gtg tgc ctg agc att cac atg 28409 Cys Thr Val Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 4800 4805 4810 ctc atc gct att cgc ccc aga aat aat gcc gaa aaa gaa aaa cag 28454 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln 4815 4820 4825 cca taacacgttt tttcacacac ctttttcaga cc atg gcc tct gtt aaa ttt 28507 Pro Met Ala Ser Val Lys Phe 4830 ttg ctt tta ttt gcc agt ctc att act gtt ata agt aat gag aaa 28552 Leu Leu Leu Phe Ala Ser Leu Ile Thr Val Ile Ser Asn Glu Lys 4835 4840 4845 ctc act att tac att ggc act aac cac act cta gaa gga att cca 28597 Leu Thr Ile Tyr Ile Gly Thr Asn His Thr Leu Glu Gly Ile Pro 4850 4855 4860 aaa tcc tca tgg tat tgc tat ttt gat caa gat cca gac tta act 28642 Lys Ser Ser Trp Tyr Cys Tyr Phe Asp Gln Asp Pro Asp Leu Thr 4865 4870 4875 ata gaa ctg tgt ggt aac aat gga caa aat aca agc att cat tta 28687 Ile Glu Leu Cys Gly Asn Asn Gly Gln Asn Thr Ser Ile His Leu 4880 4885 4890 att aac ttt aaa tgc gga gac gat ttg aaa tta att aat atc act 28732 Ile Asn Phe Lys Cys Gly Asp Asp Leu Lys Leu Ile Asn Ile Thr 4895 4900 4905 aaa gag tat gga ggt atg tat tac tat gtt gca gaa aat aac aac 28777 Lys Glu Tyr Gly Gly Met Tyr Tyr Tyr Val Ala Glu Asn Asn Asn 4910 4915 4920 atg cag ttt tat gaa gtt act gta act aat ccc acc aca cct aga 28822 Met Gln Phe Tyr Glu Val Thr Val Thr Asn Pro Thr Thr Pro Arg 4925 4930 4935 aca aca aca acc acc aca aaa act aca cct gtt acc act atg cag 28867 Thr Thr Thr Thr Thr Thr Lys Thr Thr Pro Val Thr Thr Met Gln 4940 4945 4950 ctc gct acc aat aac att ttt gcc atg cgt caa atg gtc aac aat 28912 Leu Ala Thr Asn Asn Ile Phe Ala Met Arg Gln Met Val Asn Asn 4955 4960 4965 agc act caa ccc acc cca ccc agt gag gaa att ccc aaa tcc atg 28957 Ser Thr Gln Pro Thr Pro Pro Ser Glu Glu Ile Pro Lys Ser Met 4970 4975 4980 att ggc att att gtt gct gta gtg gtg tgc atg ttg atc atc gcc 29002 Ile Gly Ile Ile Val Ala Val Val Val Cys Met Leu Ile Ile Ala 4985 4990 4995 ttg tgc atg gtg tac tat gcc ttc tgc tac aga aag cac aga ctg 29047 Leu Cys Met Val Tyr Tyr Ala Phe Cys Tyr Arg Lys His Arg Leu 5000 5005 5010 aac gac aag ctg gaa cac tta cta agt gtt gaa ttt taatttttta 29093 Asn Asp Lys Leu Glu His Leu Leu Ser Val Glu Phe 5015 5020 5025 gaacc atg aag atc cta ggc ctt tta gtt ttt tct atc att acc tct 29140 Met Lys Ile Leu Gly Leu Leu Val Phe Ser Ile Ile Thr Ser 5030 5035 gct ctt tgt gaa tca gtg gat aaa gat gtt act att acc act ggt 29185 Ala Leu Cys Glu Ser Val Asp Lys Asp Val Thr Ile Thr Thr Gly 5040 5045 5050 tct aac tat aca ctg aaa ggg cca ccc tca ggt atg ctt tcg tgg 29230 Ser Asn Tyr Thr Leu Lys Gly Pro Pro Ser Gly Met Leu Ser Trp 5055 5060 5065 tat tgc tat ttt gga aat gac gca gag caa act gag ctt tgc aat 29275 Tyr Cys Tyr Phe Gly Asn Asp Ala Glu Gln Thr Glu Leu Cys Asn 5070 5075 5080 gca atg aaa ggc caa atg cca acc aca aaa att aaa cat aaa tgt 29320 Ala Met Lys Gly Gln Met Pro Thr Thr Lys Ile Lys His Lys Cys 5085 5090 5095 gat ggt agt gat cta ata cta ctc aat gtc acg aaa gca tat ggt 29365 Asp Gly Ser Asp Leu Ile Leu Leu Asn Val Thr Lys Ala Tyr Gly 5100 5105 5110 ggc agt tat tca tgc cct gct gcc aac act gag gat atg att ttt 29410 Gly Ser Tyr Ser Cys Pro Ala Ala Asn Thr Glu Asp Met Ile Phe 5115 5120 5125 tac aaa gtg gaa gtg gtt gat ccc act act cca cca ccc acc acc 29455 Tyr Lys Val Glu Val Val Asp Pro Thr Thr Pro Pro Pro Thr Thr 5130 5135 5140 aca act act cac acc aca cac aca gaa caa acc aca gca gag gag 29500 Thr Thr Thr His Thr Thr His Thr Glu Gln Thr Thr Ala Glu Glu 5145 5150 5155 gca gca aag tta gcc ttg cag gtc caa gac agt tca ttt gtt ggc 29545 Ala Ala Lys Leu Ala Leu Gln Val Gln Asp Ser Ser Phe Val Gly 5160 5165 5170 att acc cct aca ccc gat cag cgg tgt ccg ggg ctg ctc gtc agc 29590 Ile Thr Pro Thr Pro Asp Gln Arg Cys Pro Gly Leu Leu Val Ser 5175 5180 5185 ggc att gtc ggt gtg ctt tcg gga tta gca gtc ata atc atc tgc 29635 Gly Ile Val Gly Val Leu Ser Gly Leu Ala Val Ile Ile Ile Cys 5190 5195 5200 atg ttc att ttt gct tgc tgc tat aga agg ctt tac cga caa aaa 29680 Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr Arg Gln Lys 5205 5210 5215 tca gac cca ctg ctg aac ctc tat gtt taattttttc cagagcc atg aag 29730 Ser Asp Pro Leu Leu Asn Leu Tyr Val Met Lys 5220 5225 5230 gca gtt agc act cta att ttt tgt tct ttg att ggc act gtt ttt 29775 Ala Val Ser Thr Leu Ile Phe Cys Ser Leu Ile Gly Thr Val Phe 5235 5240 5245 agt gtt agc ttt ttg aaa caa att aat gtt act gag ggg gaa aat 29820 Ser Val Ser Phe Leu Lys Gln Ile Asn Val Thr Glu Gly Glu Asn 5250 5255 5260 gtg aca ctg gta ggc gta gaa ggt gct caa aat acc acc tgg aca 29865 Val Thr Leu Val Gly Val Glu Gly Ala Gln Asn Thr Thr Trp Thr 5265 5270 5275 aaa tac cac ctc gat ggg tgg aaa gat att tgc aat tgg agt gtc 29910 Lys Tyr His Leu Asp Gly Trp Lys Asp Ile Cys Asn Trp Ser Val 5280 5285 5290 att act tac aca tgt gag gga gtt aat ttg acc ata gtc aat gcc 29955 Ile Thr Tyr Thr Cys Glu Gly Val Asn Leu Thr Ile Val Asn Ala 5295 5300 5305 agc caa aat cag aag ggt tgg att aaa ggg caa tct gtt agt gtt 30000 Ser Gln Asn Gln Lys Gly Trp Ile Lys Gly Gln Ser Val Ser Val 5310 5315 5320 acc agc cag ggg tac tat acc cag cat act ctt att tat gac att 30045 Thr Ser Gln Gly Tyr Tyr Thr Gln His Thr Leu Ile Tyr Asp Ile 5325 5330 5335 gta gtt ata ccg ctg cca acg cct agc cca cct agc acc act aca 30090 Val Val Ile Pro Leu Pro Thr Pro Ser Pro Pro Ser Thr Thr Thr 5340 5345 5350 caa aca acc cac act aca cag aca acc aca tac agt aca tca aat 30135 Gln Thr Thr His Thr Thr Gln Thr Thr Thr Tyr Ser Thr Ser Asn 5355 5360 5365 caa cct acc acc act aca gca gca gag gtt gcc agc tcg tct ggg 30180 Gln Pro Thr Thr Thr Thr Ala Ala Glu Val Ala Ser Ser Ser Gly 5370 5375 5380 gtc cga gtg gca ttt ttg tta ttg gcc cca tct agc agt ccc act 30225 Val Arg Val Ala Phe Leu Leu Leu Ala Pro Ser Ser Ser Pro Thr 5385 5390 5395 gct agt acc aat gag cag act act gat ttt ttg tcc act gtc gag 30270 Ala Ser Thr Asn Glu Gln Thr Thr Asp Phe Leu Ser Thr Val Glu 5400 5405 5410 agc cac acc aca gct acc tcg agt gcc ttc tct agc acc gcc aat 30315 Ser His Thr Thr Ala Thr Ser Ser Ala Phe Ser Ser Thr Ala Asn 5415 5420 5425 ctc tcc tcg ctt tcc tct aca cca atc agt ccc gct act act cct 30360 Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro Ala Thr Thr Pro 5430 5435 5440 agc ccc gct cct ctt ccc act ccc ctg aag caa aca gac ggc ggc 30405 Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys Gln Thr Asp Gly Gly 5445 5450 5455 atg caa tgg cag atc acc ctg ctc att gtg atc ggg ttg gtc atc 30450 Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly Leu Val Ile 5460 5465 5470 ctg gcc gtg ttg ctc tac tac atc ttc tgc cgc cgc att ccc aac 30495 Leu Ala Val Leu Leu Tyr Tyr Ile Phe Cys Arg Arg Ile Pro Asn 5475 5480 5485 gcg cac cgc aag ccg gcc tac aag ccc atc gtt atc ggg cag ccg 30540 Ala His Arg Lys Pro Ala Tyr Lys Pro Ile Val Ile Gly Gln Pro 5490 5495 5500 gag ccg ctt cag gtg gaa ggg ggt cta agg aat ctt ctc ttc tct 30585 Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser 5505 5510 5515 ttt aca gta tgg tgattgaact atgattccta gacaattctt gatcactatt 30637 Phe Thr Val Trp cttatctgcc tcctccaagt ctgtgccacc ctcgctctgg tggccaacgc cagtccagac 30697 tgtattgggc ccttcgcctc ctacgtgctc tttgccttcg tcacctgcat ctgctgctgt 30757 agcatagtct gcctgcttat caccttcttc cagttcattg actggatctt tgtgcgcatc 30817 gcctacctgc gccaccaccc ccagtaccgc gaccagcgag tggcgcggct gctcaggctc 30877 ctctgataag c atg cgg gct ctg cta ctt ctc gcg ctt ctg ctg tta 30924 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu 5520 5525 5530 gtg ctc ccc cgt ccc gtc gac ccc cgg tcc ccc act cag tcc ccc 30969 Val Leu Pro Arg Pro Val Asp Pro Arg Ser Pro Thr Gln Ser Pro 5535 5540 5545 gag gag gtc cgc aaa tgc aaa ttc caa gaa ccc tgg aaa ttc ctc 31014 Glu Glu Val Arg Lys Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu 5550 5555 5560 aaa tgc tac cgc caa aaa tca gac atg cat ccc agc tgg atc atg 31059 Lys Cys Tyr Arg Gln Lys Ser Asp Met His Pro Ser Trp Ile Met 5565 5570 5575 atc att ggg atc gtg aac att ctg gcc tgc acc ctc atc tcc ttt 31104 Ile Ile Gly Ile Val Asn Ile Leu Ala Cys Thr Leu Ile Ser Phe 5580 5585 5590 gtg att tac ccc tac ttt gac ttt ggt tgg aac tcg cca gag gcg 31149 Val Ile Tyr Pro Tyr Phe Asp Phe Gly Trp Asn Ser Pro Glu Ala 5595 5600 5605 ctc tat ctc ccg cct gaa cct gac aca cca cca cag caa cct cag 31194 Leu Tyr Leu Pro Pro Glu Pro Asp Thr Pro Pro Gln Gln Pro Gln 5610 5615 5620 gca cac gca cta cca cca cca cag cct agg cca caa tac atg ccc 31239 Ala His Ala Leu Pro Pro Pro Gln Pro Arg Pro Gln Tyr Met Pro 5625 5630 5635 ata tta gac tat gag gcc gag cca cag cga ccc atg ctc ccc gct 31284 Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg Pro Met Leu Pro Ala 5640 5645 5650 att agt tac ttc aat cta acc ggc gga gat gac tgacccactg 31327 Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 5655 5660 gccaacaaca acgtcaacga ccttctcctg gacatggacg gccgcgcctc ggagcagcga 31387 ctcgcccaac ttcgcattcg ccagcagcag gagagagccg tcaaggagct gcaggacggc 31447 atagccatcc accagtgcaa gaaaggcatc ttctgcctgg tgaaacaggc caagatctcc 31507 tacgaggtca cccagaccga ccatcgcctc tcctacgagc tcctgcagca gcgccagaag 31567 ttcacctgcc tggtcggagt caaccccatc gtcatcaccc agcagtcggg agataccaag 31627 gggtgcatcc actgctcctg cgactccccc gactgcgtcc acactctgat caagaccctc 31687 tgcggcctcc gcgacctcct ccccatgaac taatcacccc cttatccagt gaaataaaga 31747 tcatattgat gattaaataa aaaaaataat catttgattt gaaataaaga tacaatcata 31807 ttgatgattt gagtttaata aaaataaaga atcacttact tgaaatctga taccaggtct 31867 ctgtccatgt tttctgccaa caccacttca ctcccctctt cccagctctg gtactgcagg 31927 ccccggcggg ctgcaaactt cctccacacc ctgaagggga tgtcaaattc ctcctgtccc 31987 tcaatcttca ttttatcttc tatcag atg tcc aaa aag cgc gtc cgg gtg 32037 Met Ser Lys Lys Arg Val Arg Val 5665 5670 gat gat gac ttc gac ccc gtc tac ccc tac gat gca gac aac gca 32082 Asp Asp Asp Phe Asp Pro Val Tyr Pro Tyr Asp Ala Asp Asn Ala 5675 5680 5685 ccg acc gtg ccc ttc atc aac ccc ccc ttc gtc tct tca gat gga 32127 Pro Thr Val Pro Phe Ile Asn Pro Pro Phe Val Ser Ser Asp Gly 5690 5695 5700 ttc caa gag aag ccc ctg ggg gtg ttg tcc ctg cga ctg gcc gac 32172 Phe Gln Glu Lys Pro Leu Gly Val Leu Ser Leu Arg Leu Ala Asp 5705 5710 5715 ccc gtc acc acc aag aac ggg gaa atc acc ctc aag ctg gga gag 32217 Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu Lys Leu Gly Glu 5720 5725 5730 ggg gtg gac ctc gac gac tcg gga aaa ctc atc tcc aaa aat gcc 32262 Gly Val Asp Leu Asp Asp Ser Gly Lys Leu Ile Ser Lys Asn Ala 5735 5740 5745 acc aag gcc act gcc cct ctc agt att tcc aac agc acc att tcc 32307 Thr Lys Ala Thr Ala Pro Leu Ser Ile Ser Asn Ser Thr Ile Ser 5750 5755 5760 ctt aac atg gat gcc cct ctt tac aac aac aat gga aag tta ggc 32352 Leu Asn Met Asp Ala Pro Leu Tyr Asn Asn Asn Gly Lys Leu Gly 5765 5770 5775 ata aga ata gga gca cct cta aag gta gta gac tta cta aac act 32397 Ile Arg Ile Gly Ala Pro Leu Lys Val Val Asp Leu Leu Asn Thr 5780 5785 5790 tta gct gta gcc tat gga tcg ggt cta ggt ctc aag aat aat gcc 32442 Leu Ala Val Ala Tyr Gly Ser Gly Leu Gly Leu Lys Asn Asn Ala 5795 5800 5805 ctt aca gtt cag tta gtt tct cca ctc act ttt gat aac aaa ggc 32487 Leu Thr Val Gln Leu Val Ser Pro Leu Thr Phe Asp Asn Lys Gly 5810 5815 5820 aat gta aaa att aam tta ggg aaa ggc cca tta aca gtt gcg gca 32532 Asn Val Lys Ile Xaa Leu Gly Lys Gly Pro Leu Thr Val Ala Ala 5825 5830 5835 aac cga ctg agt gtt acc tgc aaa aga ggt tta tat gtc act act 32577 Asn Arg Leu Ser Val Thr Cys Lys Arg Gly Leu Tyr Val Thr Thr 5840 5845 5850 aca gga gat gca ctc gaa agc aac ata agc tgg gct aaa ggt ata 32622 Thr Gly Asp Ala Leu Glu Ser Asn Ile Ser Trp Ala Lys Gly Ile 5855 5860 5865 aga ttt gaa gga aat gca ata gca gca aat att ggc aaa ggg ctt 32667 Arg Phe Glu Gly Asn Ala Ile Ala Ala Asn Ile Gly Lys Gly Leu 5870 5875 5880 gaa ttt ggt act act agt tca gag tca gat gtc agc aat gct tat 32712 Glu Phe Gly Thr Thr Ser Ser Glu Ser Asp Val Ser Asn Ala Tyr 5885 5890 5895 cct atc caa gta aaa cta ggt act ggt ctc acc ttt gac agc aca 32757 Pro Ile Gln Val Lys Leu Gly Thr Gly Leu Thr Phe Asp Ser Thr 5900 5905 5910 ggt gcc att gtt gct tgg aac aaa gag gat gac aag ctt aca ttg 32802 Gly Ala Ile Val Ala Trp Asn Lys Glu Asp Asp Lys Leu Thr Leu 5915 5920 5925 tgg acc aca gcc gac cca tcg cca aat tgc aaa ata tac tct gaa 32847 Trp Thr Thr Ala Asp Pro Ser Pro Asn Cys Lys Ile Tyr Ser Glu 5930 5935 5940 aag gat gca aaa ctt aca ctt tgc ttg aca aag tgt ggt agt caa 32892 Lys Asp Ala Lys Leu Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln 5945 5950 5955 ata ttg ggc act gtg aca gta ttg gct gtt aac aat ggg agc tta 32937 Ile Leu Gly Thr Val Thr Val Leu Ala Val Asn Asn Gly Ser Leu 5960 5965 5970 aac ccc att aca aac aca gtg agc act gca att gta tat ctc aag 32982 Asn Pro Ile Thr Asn Thr Val Ser Thr Ala Ile Val Tyr Leu Lys 5975 5980 5985 ttt gat gct aat gga gtc ttg cta agc aac tca aca cta aac aaa 33027 Phe Asp Ala Asn Gly Val Leu Leu Ser Asn Ser Thr Leu Asn Lys 5990 5995 6000 gaa tat tgg aat ttc aga aag gga gat gtt aca cct gcc gaa gca 33072 Glu Tyr Trp Asn Phe Arg Lys Gly Asp Val Thr Pro Ala Glu Ala 6005 6010 6015 tac act aat gct ata ggt ttt atg cct aac ata aag gcc tat cct 33117 Tyr Thr Asn Ala Ile Gly Phe Met Pro Asn Ile Lys Ala Tyr Pro 6020 6025 6030 aaa aac aca tct gca gct tca aaa agt cat att gtt ggc caa gtt 33162 Lys Asn Thr Ser Ala Ala Ser Lys Ser His Ile Val Gly Gln Val 6035 6040 6045 tac cta aat gga gat gaa acc aaa cct ctt atg cta att atc aca 33207 Tyr Leu Asn Gly Asp Glu Thr Lys Pro Leu Met Leu Ile Ile Thr 6050 6055 6060 ttt aat gaa act gat gat gca acc tgc acc tac tgc att act ttt 33252 Phe Asn Glu Thr Asp Asp Ala Thr Cys Thr Tyr Cys Ile Thr Phe 6065 6070 6075 caa tgg aaa tgg gat aat agt aag tac aca ggt gaa aca ctt gca 33297 Gln Trp Lys Trp Asp Asn Ser Lys Tyr Thr Gly Glu Thr Leu Ala 6080 6085 6090 acc agc tcc ttt ccc ttc tcc tac att gcc caa gaa taaaccaccc 33343 Thr Ser Ser Phe Pro Phe Ser Tyr Ile Ala Gln Glu 6095 6100 tgcatgacac cccttgtccc actgctctac aatggaaaac tctgaagcag aaaaataaag 33403 ttcaagtgtt ttattgattc aacagtttta caggactcga gcagttattt ttcctccacc 33463 ctcccaggac atggaataca ccaccctctc cccccgcaca gccttgaaca tctgaatgtc 33523 attggtgatg gacatgcttt tggtctccac gttccacaca gtttcagagc gagccagtct 33583 cgggtcggtc agggagatga aaccctccgg gcactcccgc atctgcacct cacagctcaa 33643 cagctgagga ttgtcctcgg tggtcgggat cacggttatc tggaagaagc agaagagcgg 33703 cggtgggaat catagtccgc gaacgggatc ggccggtggt gtcgcatcag gccccgcagc 33763 agtcgctgtc gccgccgctc cgtcaaactg ctgctcaggg ggtccgggtc cagggactcc 33823 ctcagcatga tgcccacggc cctcagcatc agtcgcctgg tgcggcgggc gcagcagcgc 33883 atgcggatct cgctcaggtc gctgcagtac gtgcaacaca ggaccaccag gttgttcaac 33943 agtccatagt tcaacacgct ccagccgaaa ctcatcgcgg gaaggatgct acccacgtgg 34003 ccgtcgtacc agatcctcag gtaaatcaag tggcgctccc tccagaacac gctgcccaca 34063 tacatgatct ccttgggcat gtggcggttc accacctccc ggtaccacat caccctctgg 34123 ttgaacatgc agccccggat gatcctgcgg aaccacaggg ccagcaccgc cccgcccgcc 34183 atgcagcgaa gagaccccgg gtcccggcaa tggcaatgga ggacccaccg ctcgtacccg 34243 tggatcatct gggagctgaa caagtctatg ttggcacagc acaggcacac gctcatgcat 34303 ctcttcagca ctctcagctc ctcgggggtc aaaaccatat cccagggcac ggggaactct 34363 tgcaggacag cgaaccccgc agaacagggc aatcctcgca cataacttac attgtgcatg 34423 gacagggtat cgcaatcagg cagcaccggg tgatcctcca ccagagaagc gcgggtctcg 34483 gtttcctcac agcgtggtaa gggggccggc cgatacgggt gatggcggga cgcggctgat 34543 cgtgttctcg accgtgtcat gatgcagttg ctttcggaca ttttcgtact tgctgtagca 34603 gaacctggtc cgggcgctgc acaccgatcg ccggcggcgg tctcggcgct tggaacgctc 34663 ggtgttgaaa ttgtaaaaca gccactctct cagaccgtgc agcagatcta gggcctcagg 34723 agtgatgaag atcccatcat gcctgatggc tctgatcaca tcgaccaccg tggaatgggc 34783 cagacccagc cagatgatgc aattttgttg ggtttcggtg acggcggggg agggaagaac 34843 aggaagaacc atgattaact tttaatccaa acggtctcgg agcacttcaa aatgaaggtc 34903 gcggagatgg cacctctcgc ccccgctgtg ttggtggaaa ataacagcca ggtcaaaggt 34963 gatacggttc tcgagatgtt ccacggtggc ttccagcaaa gcctccacgc gcacatccag 35023 aaacaagaca atagcgaaag cgggagggtt ctctaattcc tcaatcatca tgttacactc 35083 ctgcaccatc cccagataat tttcattttt ccagccttga atgattcgaa ctagttcctg 35143 aggtaaatcc aagccagcca tgataaagag ctcgcgcaga gcgccctcca ccggcattct 35203 taagcacacc ctcataattc caagatattc tgctcctggt tcacctgcag cagattgaca 35263 agcggaatat caaaatctct gccgcgatcc ctgagctcct ccctcagcaa taactgtaag 35323 tactctttca tatcctctcc aaaattttta gccataggac caccaggaat aagattagga 35383 caagccacag tacagataaa ccgaagtcct ccccagtgag cattgccaaa tgcaagactg 35443 ctataagcat gctggctaga cccggtgata tcttccagat aactggacag aaaatcgccc 35503 aggcaatttt taagaaaatc aacaaaagaa aaatcctcca ggtgcacgtt tagagcctcg 35563 ggaacaacga tggagtaaat gcaagcggtg cgttccagca tggttagtta gctgatctgt 35623 agaaaaaaca aaaatgaaca ttaaaccatg ctagcctggc gaacaggtgg gtaaatcgtt 35683 ctctccagca ccaggcaggc cacggggtct ccggcgcgac cctcgtaaaa attgtcgcta 35743 tgattgaaaa ccatcacaga gagacgttcc cggtggccgg cgtggatgat tcgacaagat 35803 gaatacaccc ccggaacatt ggcgtccgcg agtgaaaaaa agcgcccaag gaagcaataa 35863 ggcactacaa tgctcagtct caagtccagc aaagcgatgc catgcggatg aagcacaaaa 35923 ttctcaggtg cgtacaaaat gtaattactc ccctcctgca caggcagcaa agcccccgat 35983 ccctccagat acacatacaa agcctcagcg tccatagctt accgagcagc agcacacaac 36043 aggcgcaaga gtcagagaaa ggctgagctc taacctgtcc acccgctctc tgctcaatat 36103 atagcccaga tctacactga cgtaaaggcc aaagtctaaa aatacccgcc aaataatcac 36163 acacgcccaa cacacgccca gaaaccggtg acacactcag aaaaatacgc gcacttcctc 36223 aaacgcccaa actgccgtca tttccgggtt cccacgctac gtcatcagaa ttcgactttc 36283 aaattccgtc gaccgttaaa aacgtcaccc gccccgcccc taacggtcgc cgctcccgca 36343 gccaatcaca gccccgcagc cccaaattca aacgcctcat ttgcatatta acacgcacaa 36403 aaagtttgag gtatattatt gatgatg 36430 <210> 2 <211> 193 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 2 Met Glu Ile Trp Thr Val Leu Glu Asp Phe His Gln Thr Arg Gln Leu 1 5 10 15 Leu Glu Asn Ser Ser Glu Glu Val Ser Tyr Leu Trp Arg Phe Cys Phe 20 25 30 Gly Gly Ala Leu Ala Lys Leu Val His Arg Ala Lys Gln Asp Tyr Lys 35 40 45 Asp Gln Phe Glu Asp Ile Leu Arg Glu Cys Pro Gly Ile Phe Asp Ser 50 55 60 Leu Asn Leu Gly His Gln Ser His Phe Asn Gln Ser Ile Leu Arg Ala 65 70 75 80 Leu Asp Phe Ser Thr Pro Gly Arg Thr Thr Ala Ala Val Ala Phe Phe 85 90 95 Ala Phe Ile Leu Asp Lys Trp Ser Gln Glu Thr His Phe Ser Arg Asp 100 105 110 Tyr Arg Leu Asp Cys Leu Ala Val Ala Leu Trp Arg Thr Trp Arg Cys 115 120 125 Gln Arg Leu Asn Ala Ile Ser Gly Tyr Leu Pro Val Gln Pro Val Asp 130 135 140 Thr Leu Arg Ile Leu Ser Leu Gln Ser Pro Gln Glu His Gln Arg Arg 145 150 155 160 Gln Gln Pro Gln Gln Glu Gln Gln Gln Glu Glu Glu Glu Glu Asp Arg 165 170 175 Glu Glu Asn Pro Arg Ala Gly Leu Asp Pro Pro Val Ala Glu Glu Glu 180 185 190 Glu <210> 3 <211> 393 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 3 Met His Pro Val Leu Arg Gln Met Arg Pro His His Pro Pro Pro Gln 1 5 10 15 Gln Gln Pro Pro Pro Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln 20 25 30 Gln Gln Leu Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala Gly 35 40 45 Gln Ser Tyr Asp His Gln Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala 50 55 60 Arg Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys 65 70 75 80 Arg Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp 85 90 95 Arg Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ser Arg Phe His Ala 100 105 110 Gly Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp 115 120 125 Glu Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala 130 135 140 His Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys 145 150 155 160 Glu Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu 165 170 175 Ile Ala Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu 180 185 190 Leu Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln 195 200 205 Leu Phe Leu Val Val Gln His Ser Arg Asp Asn Glu Thr Phe Arg Glu 210 215 220 Ala Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu 225 230 235 240 Val Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu 245 250 255 Ser Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys 260 265 270 Tyr Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys 275 280 285 Glu Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu 290 295 300 Thr Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg 305 310 315 320 Ala Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met 325 330 335 His Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser 340 345 350 Tyr Phe Asp Met Gly Ala Asp Leu Arg Trp Gln Pro Ser Arg Arg Ala 355 360 365 Leu Glu Ala Ala Gly Gly Val Pro Tyr Val Glu Glu Val Asp Asp Glu 370 375 380 Glu Glu Glu Gly Glu Tyr Leu Glu Asp 385 390 <210> 4 <211> 586 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 4 Met Gln Gln Gln Pro Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu 1 5 10 15 Gln Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala 20 25 30 Met Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg 35 40 45 Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val 50 55 60 Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn 65 70 75 80 Ala Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val 85 90 95 Tyr Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val 100 105 110 Gln Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ser 115 120 125 Gln Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala 130 135 140 Leu Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln 145 150 155 160 Glu Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Ala Glu 165 170 175 Val Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln 180 185 190 Thr Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys 195 200 205 Asn Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala 210 215 220 Thr Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu 225 230 235 240 Val Ala Pro Phe Thr Asp Ser Gly Ser Val Ser Arg Asp Ser Tyr Leu 245 250 255 Gly Tyr Leu Leu Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val 260 265 270 Asp Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly 275 280 285 Gln Glu Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr 290 295 300 Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu 305 310 315 320 Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met 325 330 335 Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn 340 345 350 Met Glu Pro Ser Met Tyr Ala Arg Asn Arg Pro Phe Ile Asn Lys Leu 355 360 365 Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr 370 375 380 Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr 385 390 395 400 Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp 405 410 415 Val Asp Ser Ser Val Phe Ser Pro Arg Pro Thr Thr Thr Val Trp Lys 420 425 430 Lys Glu Gly Gly Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly Arg Ala 435 440 445 Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu 450 455 460 Pro Phe Ser Leu Asn Ser Val Arg Ser Ser Glu Leu Gly Arg Leu Thr 465 470 475 480 Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu 485 490 495 Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu 500 505 510 Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala His Glu His Arg Asp 515 520 525 Glu Pro Arg Ala Ser Ser Ser Thr Gly Ala Arg Arg Arg Gln Arg His 530 535 540 Asp Arg Gln Arg Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp Asp 545 550 555 560 Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe Ala 565 570 575 His Leu Arg Pro Arg Ile Gly Arg Leu Met 580 585 <210> 5 <211> 528 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 5 Met Met Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Val Ala Ala Ala Met Gln Pro Pro Leu Glu Ala 20 25 30 Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg Asn Ser 35 40 45 Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg Leu Tyr 50 55 60 Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr Gln Asn 65 70 75 80 Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp Phe Thr 85 90 95 Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg 100 105 110 Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro Asn Val 115 120 125 Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser 130 135 140 Arg Lys Thr Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln Asp Glu 145 150 155 160 Leu Thr Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn Phe Ser 165 170 175 Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr 180 185 190 Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val 195 200 205 Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val Thr Glu 210 215 220 Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro Asp Ile 225 230 235 240 Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg Leu Ser 245 250 255 Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly Phe Gln 260 265 270 Ile Leu Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp 275 280 285 Val Asp Ala Tyr Glu Lys Ser Lys Glu Glu Ser Ala Ala Ala Ala Thr 290 295 300 Ala Ala Val Ala Thr Ala Ser Thr Glu Val Arg Gly Asp Asn Phe Ala 305 310 315 320 Ser Ala Ala Ala Val Ala Glu Ala Ala Glu Thr Glu Ser Lys Ile Val 325 330 335 Ile Gln Pro Val Glu Lys Asp Ser Lys Asp Arg Ser Tyr Asn Val Leu 340 345 350 Ala Asp Lys Lys Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn 355 360 365 Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr 370 375 380 Ser Asp Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser Leu Pro Asp 385 390 395 400 Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn 405 410 415 Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser Phe 420 425 430 Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Ala Phe Thr Ser 435 440 445 Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Val Arg 450 455 460 Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu 465 470 475 480 Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln 485 490 495 Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr 500 505 510 Lys Ala Leu Gly Val Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 515 520 525 <210> 6 <211> 344 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 6 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys Glu Glu Arg Lys Pro Arg 20 25 30 Lys Leu Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Asp Val Asp Asp 35 40 45 Met Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp 50 55 60 Arg Gly Arg Lys Val Arg Pro Val Leu Arg Pro Gly Thr Thr Val Val 65 70 75 80 Phe Thr Pro Gly Glu Arg Ser Gly Thr Ala Ser Lys Arg Ser Tyr Asp 85 90 95 Glu Val Tyr Gly Asp Asp Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu 100 105 110 Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Pro Ala Pro Leu Lys Glu 115 120 125 Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu 130 135 140 Lys Pro Val Thr Leu Gln Gln Val Leu Pro Ala Ala Ala Pro Arg Arg 145 150 155 160 Gly Phe Lys Arg Glu Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met 165 170 175 Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu His Met Lys Val 180 185 190 Asp Pro Asp Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln Val 195 200 205 Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr Glu 210 215 220 Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr Met 225 230 235 240 Glu Val Gln Thr Asp Pro Trp Met Pro Ala Ala Ser Thr Thr Thr Arg 245 250 255 Arg Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn Tyr Ala 260 265 270 Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg Phe 275 280 285 Tyr Arg Gly Tyr Thr Ser Ser Arg Arg Arg Lys Thr Thr Thr Arg Arg 290 295 300 Arg Arg Arg Arg Ser Arg Arg Ser Ser Thr Ala Thr Ser Ala Leu Val 305 310 315 320 Arg Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu Thr Leu Pro Arg Ala 325 330 335 Arg Tyr His Pro Ser Ile Ala Ile 340 <210> 7 <211> 77 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 7 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly Asn Gly Leu Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 8 <211> 241 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 8 Met Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg 1 5 10 15 Pro Phe Met Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly 20 25 30 Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly 35 40 45 Ser Thr Leu Lys Thr Tyr Gly Asn Lys Ala Trp Asn Ser Ser Thr Gly 50 55 60 Gln Ala Leu Arg Glu Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val 65 70 75 80 Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn 85 90 95 Gln Ala Val Gln Lys Gln Ile Asn Ser Arg Leu Asp Ala Val Pro Pro 100 105 110 Ala Gly Ser Val Asp Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu 115 120 125 Asp Lys Arg Gly Asp Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu 130 135 140 Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu 145 150 155 160 Gly Leu Pro Thr Thr Arg Pro Val Ala Pro Leu Ala Thr Gly Val Leu 165 170 175 Lys Pro Ser Ser Ser Ser Ser Gln Pro Ala Thr Leu Asp Leu Pro Pro 180 185 190 Pro Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val Ala 195 200 205 Ser Arg Ala Pro Arg Gly Arg Pro Gln Ala Asn Trp Gln Ser Thr Leu 210 215 220 Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg Arg Arg Cys 225 230 235 240 Tyr <210> 9 <211> 950 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 9 Met Tyr Val Arg Arg Pro Glu Gly Gly Arg Gly Ala Ser Pro Ser Cys 1 5 10 15 Lys Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile 20 25 30 Ala Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe 35 40 45 Ala Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn 50 55 60 Pro Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg 65 70 75 80 Leu Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser 85 90 95 Tyr Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp 100 105 110 Met Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro 115 120 125 Ser Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys 130 135 140 Gly Ala Pro Asn Thr Ser Gln Trp Ile Thr Lys Asp Lys Thr Tyr Ser 145 150 155 160 Phe Gly Asn Ala Pro Val Arg Gly Leu Asp Ile Thr Glu Glu Gly Leu 165 170 175 Gln Ile Val Thr Asp Glu Ser Gly Gly Glu Ser Lys Lys Ile Phe Ala 180 185 190 Asp Lys Thr Tyr Gln Pro Glu Pro Gln Leu Gly Asp Glu Glu Trp His 195 200 205 Asp Thr Ile Gly Ala Glu Asp Lys Tyr Gly Gly Arg Ala Leu Lys Pro 210 215 220 Ala Thr Asn Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys Pro Thr Asn 225 230 235 240 Ala Lys Gly Gly Gln Ala Lys Ser Arg Thr Lys Asp Asp Gly Thr Thr 245 250 255 Glu Pro Asp Ile Asp Met Ala Phe Phe Asp Asp Arg Ser Gln Gln Ala 260 265 270 Ser Phe Ser Pro Glu Leu Val Leu Tyr Thr Glu Asn Val Asp Leu Asp 275 280 285 Thr Pro Asp Thr His Ile Ile Tyr Lys Pro Gly Thr Asp Glu Thr Ser 290 295 300 Ser Ser Phe Asn Leu Gly Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr 305 310 315 320 Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr 325 330 335 Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val 340 345 350 Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu 355 360 365 Asp Ser Leu Gly Asp Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala 370 375 380 Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Val 385 390 395 400 Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asn Gly Val Gly Phe 405 410 415 Thr Asp Ser Phe Gln Gly Ile Lys Val Lys Thr Thr Asn Asn Gly Thr 420 425 430 Ala Asn Ala Thr Glu Trp Glu Ser Asp Thr Ser Val Asn Asn Ala Asn 435 440 445 Glu Ile Ala Lys Gly Asn Pro Phe Ala Met Glu Ile Asn Ile Gln Ala 450 455 460 Asn Leu Trp Arg Asn Phe Leu Tyr Ala Asn Val Ala Leu Tyr Leu Pro 465 470 475 480 Asp Ser Tyr Lys Tyr Thr Pro Ala Asn Ile Thr Leu Pro Thr Asn Thr 485 490 495 Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val Val Ala Pro Ser Leu Val 500 505 510 Asp Ala Tyr Ile Asn Ile Gly Ala Arg Trp Ser Leu Asp Pro Met Asp 515 520 525 Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg 530 535 540 Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val 545 550 555 560 Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu Leu Leu Leu Pro Gly Ser 565 570 575 Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met Ile Leu Gln 580 585 590 Ser Ser Leu Gly Asn Asp Leu Arg Thr Asp Gly Ala Ser Ile Ser Phe 595 600 605 Thr Ser Ile Asn Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr 610 615 620 Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser 625 630 635 640 Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala 645 650 655 Asn Ala Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala 660 665 670 Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser 675 680 685 Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro 690 695 700 Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser 705 710 715 720 Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu 725 730 735 Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr 740 745 750 Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met 755 760 765 Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly 770 775 780 Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser 785 790 795 800 Arg Gln Val Val Asp Glu Val Asn Tyr Lys Asp Tyr Gln Ala Val Thr 805 810 815 Leu Ala Tyr Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro 820 825 830 Thr Met Arg Gln Gly Gln Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu 835 840 845 Ile Gly Lys Ser Ala Val Thr Ser Val Thr Gln Lys Lys Phe Leu Cys 850 855 860 Asp Arg Val Met Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met 865 870 875 880 Gly Ala Leu Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala 885 890 895 His Ala Leu Asp Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr 900 905 910 Leu Leu Tyr Val Val Phe Glu Val Phe Asp Val Val Arg Val His Gln 915 920 925 Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser 930 935 940 Ala Gly Asn Ala Thr Thr 945 950 <210> 10 <211> 209 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 10 Met Met Ala Glu Pro Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile 1 5 10 15 Ile Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys 20 25 30 Arg Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val 35 40 45 Asn Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala 50 55 60 Trp Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe 65 70 75 80 Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu 85 90 95 Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu 100 105 110 Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu 115 120 125 Phe Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro 130 135 140 Met Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly 145 150 155 160 Met Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu 165 170 175 Ala Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe Arg Ser His 180 185 190 Arg Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Gln Asp 195 200 205 Met <210> 11 <211> 797 <212> PRT <213> Unknown <220> <221> misc_feature <222> (789)..(789) <223> The 'Xaa' at location 789 stands for Ser. <220> <223> Synthetic Construct <400> 11 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ala 1 5 10 15 Ala Asp Glu Asn Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro 20 25 30 Pro Ser Pro Thr Ser Asp Ala Ala Ala Ala Pro Asp Met Gln Glu Met 35 40 45 Glu Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His 50 55 60 Glu Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln 65 70 75 80 Glu Gln Pro Glu Gln Glu Ala Glu Ser Glu Gln Gln Gln Ala Gly Leu 85 90 95 Glu His Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu Ile Lys His 100 105 110 Leu Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Ala 115 120 125 Glu Val Pro Leu Ser Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg Asn 130 135 140 Leu Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys 145 150 155 160 Glu Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu 165 170 175 Ala Leu Ala Thr Tyr His Leu Phe Phe Lys Asn Gln Arg Ile Pro Val 180 185 190 Ser Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Leu Asn Leu Gly 195 200 205 Pro Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro Lys 210 215 220 Ile Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu 225 230 235 240 Gln Gly Ser Gly Glu Glu His Glu His His Ser Ala Leu Val Glu Leu 245 250 255 Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu 260 265 270 Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser 275 280 285 Ala Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu 290 295 300 Glu Glu Met Gln Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val Val 305 310 315 320 Ser Asp Glu Gln Leu Ala Arg Trp Leu Gly Ala Ser Ser Thr Pro Gln 325 330 335 Ser Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr 340 345 350 Val Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu 355 360 365 Arg Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val 370 375 380 Arg Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser 385 390 395 400 Tyr Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His 405 410 415 Thr Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val 420 425 430 Tyr Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln 435 440 445 Gln Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln 450 455 460 Lys Asn Leu Lys Ala Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala 465 470 475 480 Ser Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu 485 490 495 Arg Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe 500 505 510 Arg Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser 515 520 525 Ala Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro 530 535 540 Pro Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala 545 550 555 560 Tyr His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu 565 570 575 Cys His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys 580 585 590 Asn Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu 595 600 605 Gln Gly Pro Gly Asp Gly Lys Gly Gly Leu Lys Leu Thr Pro Gly Leu 610 615 620 Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr His Pro 625 630 635 640 Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys Ala Glu 645 650 655 Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala Gln Leu Gln 660 665 670 Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly His Gly 675 680 685 Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro Ser Phe Pro 690 695 700 Gln Asp Ala Pro Arg Lys Gln Gln Glu Ala Glu Ser Gly Ala Ala Ala 705 710 715 720 Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly Asp Gly 725 730 735 Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln Pro Ala Arg Gln Ser 740 745 750 Gly Arg Arg Gly Gly Gly Gly Gly Arg Gly Arg Ser Ser Arg Arg Gln 755 760 765 Thr Val Val Leu Gly Gly Gly Gly Glu Ser Lys Gln His Gly Tyr His 770 775 780 Leu Arg Ser Gly Xaa Gly Ser Arg Arg Pro Gly Pro Gln 785 790 795 <210> 12 <211> 227 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 12 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr 50 55 60 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Thr Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 13 <211> 106 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 13 Met Ser His Gly Gly Val Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Ala 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Ile Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Arg Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asn His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 14 <211> 176 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 14 Met Gly Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val Leu 1 5 10 15 Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu Glu Lys Ala 20 25 30 Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Val Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Ala His Met Cys Asp Thr Val Met Trp Met Ser Lys Gln Tyr Asp Met 115 120 125 Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Leu Cys Thr Val Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 15 <211> 198 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 15 Met Ala Ser Val Lys Phe Leu Leu Leu Phe Ala Ser Leu Ile Thr Val 1 5 10 15 Ile Ser Asn Glu Lys Leu Thr Ile Tyr Ile Gly Thr Asn His Thr Leu 20 25 30 Glu Gly Ile Pro Lys Ser Ser Trp Tyr Cys Tyr Phe Asp Gln Asp Pro 35 40 45 Asp Leu Thr Ile Glu Leu Cys Gly Asn Asn Gly Gln Asn Thr Ser Ile 50 55 60 His Leu Ile Asn Phe Lys Cys Gly Asp Asp Leu Lys Leu Ile Asn Ile 65 70 75 80 Thr Lys Glu Tyr Gly Gly Met Tyr Tyr Tyr Val Ala Glu Asn Asn Asn 85 90 95 Met Gln Phe Tyr Glu Val Thr Val Thr Asn Pro Thr Thr Pro Arg Thr 100 105 110 Thr Thr Thr Thr Thr Lys Thr Thr Pro Val Thr Thr Met Gln Leu Ala 115 120 125 Thr Asn Asn Ile Phe Ala Met Arg Gln Met Val Asn Asn Ser Thr Gln 130 135 140 Pro Thr Pro Pro Ser Glu Glu Ile Pro Lys Ser Met Ile Gly Ile Ile 145 150 155 160 Val Ala Val Val Val Cys Met Leu Ile Ile Ala Leu Cys Met Val Tyr 165 170 175 Tyr Ala Phe Cys Tyr Arg Lys His Arg Leu Asn Asp Lys Leu Glu His 180 185 190 Leu Leu Ser Val Glu Phe 195 <210> 16 <211> 203 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 16 Met Lys Ile Leu Gly Leu Leu Val Phe Ser Ile Ile Thr Ser Ala Leu 1 5 10 15 Cys Glu Ser Val Asp Lys Asp Val Thr Ile Thr Thr Gly Ser Asn Tyr 20 25 30 Thr Leu Lys Gly Pro Pro Ser Gly Met Leu Ser Trp Tyr Cys Tyr Phe 35 40 45 Gly Asn Asp Ala Glu Gln Thr Glu Leu Cys Asn Ala Met Lys Gly Gln 50 55 60 Met Pro Thr Thr Lys Ile Lys His Lys Cys Asp Gly Ser Asp Leu Ile 65 70 75 80 Leu Leu Asn Val Thr Lys Ala Tyr Gly Gly Ser Tyr Ser Cys Pro Ala 85 90 95 Ala Asn Thr Glu Asp Met Ile Phe Tyr Lys Val Glu Val Val Asp Pro 100 105 110 Thr Thr Pro Pro Pro Thr Thr Thr Thr Thr His Thr Thr His Thr Glu 115 120 125 Gln Thr Thr Ala Glu Glu Ala Ala Lys Leu Ala Leu Gln Val Gln Asp 130 135 140 Ser Ser Phe Val Gly Ile Thr Pro Thr Pro Asp Gln Arg Cys Pro Gly 145 150 155 160 Leu Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly Leu Ala Val Ile 165 170 175 Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr Arg 180 185 190 Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 195 200 <210> 17 <211> 291 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 17 Met Lys Ala Val Ser Thr Leu Ile Phe Cys Ser Leu Ile Gly Thr Val 1 5 10 15 Phe Ser Val Ser Phe Leu Lys Gln Ile Asn Val Thr Glu Gly Glu Asn 20 25 30 Val Thr Leu Val Gly Val Glu Gly Ala Gln Asn Thr Thr Trp Thr Lys 35 40 45 Tyr His Leu Asp Gly Trp Lys Asp Ile Cys Asn Trp Ser Val Ile Thr 50 55 60 Tyr Thr Cys Glu Gly Val Asn Leu Thr Ile Val Asn Ala Ser Gln Asn 65 70 75 80 Gln Lys Gly Trp Ile Lys Gly Gln Ser Val Ser Val Thr Ser Gln Gly 85 90 95 Tyr Tyr Thr Gln His Thr Leu Ile Tyr Asp Ile Val Val Ile Pro Leu 100 105 110 Pro Thr Pro Ser Pro Pro Ser Thr Thr Thr Gln Thr Thr His Thr Thr 115 120 125 Gln Thr Thr Thr Tyr Ser Thr Ser Asn Gln Pro Thr Thr Thr Thr Ala 130 135 140 Ala Glu Val Ala Ser Ser Ser Gly Val Arg Val Ala Phe Leu Leu Leu 145 150 155 160 Ala Pro Ser Ser Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Asp 165 170 175 Phe Leu Ser Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe 180 185 190 Ser Ser Thr Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro 195 200 205 Ala Thr Thr Pro Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys Gln Thr 210 215 220 Asp Gly Gly Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly Leu 225 230 235 240 Val Ile Leu Ala Val Leu Leu Tyr Tyr Ile Phe Cys Arg Arg Ile Pro 245 250 255 Asn Ala His Arg Lys Pro Ala Tyr Lys Pro Ile Val Ile Gly Gln Pro 260 265 270 Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser Phe 275 280 285 Thr Val Trp 290 <210> 18 <211> 143 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 18 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu Val Leu Pro Arg 1 5 10 15 Pro Val Asp Pro Arg Ser Pro Thr Gln Ser Pro Glu Glu Val Arg Lys 20 25 30 Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys 35 40 45 Ser Asp Met His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile 50 55 60 Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Tyr Phe Asp Phe 65 70 75 80 Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr 85 90 95 Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Pro Gln Pro Arg 100 105 110 Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg Pro 115 120 125 Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 130 135 140 <210> 19 <211> 440 <212> PRT <213> Unknown <220> <221> misc_feature <222> (163)..(163) <223> The 'Xaa' at location 163 stands for Lys, or Asn. <220> <223> Synthetic Construct <400> 19 Met Ser Lys Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro Val Tyr 1 5 10 15 Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro 20 25 30 Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser 35 40 45 Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu 50 55 60 Lys Leu Gly Glu Gly Val Asp Leu Asp Asp Ser Gly Lys Leu Ile Ser 65 70 75 80 Lys Asn Ala Thr Lys Ala Thr Ala Pro Leu Ser Ile Ser Asn Ser Thr 85 90 95 Ile Ser Leu Asn Met Asp Ala Pro Leu Tyr Asn Asn Asn Gly Lys Leu 100 105 110 Gly Ile Arg Ile Gly Ala Pro Leu Lys Val Val Asp Leu Leu Asn Thr 115 120 125 Leu Ala Val Ala Tyr Gly Ser Gly Leu Gly Leu Lys Asn Asn Ala Leu 130 135 140 Thr Val Gln Leu Val Ser Pro Leu Thr Phe Asp Asn Lys Gly Asn Val 145 150 155 160 Lys Ile Xaa Leu Gly Lys Gly Pro Leu Thr Val Ala Ala Asn Arg Leu 165 170 175 Ser Val Thr Cys Lys Arg Gly Leu Tyr Val Thr Thr Thr Gly Asp Ala 180 185 190 Leu Glu Ser Asn Ile Ser Trp Ala Lys Gly Ile Arg Phe Glu Gly Asn 195 200 205 Ala Ile Ala Ala Asn Ile Gly Lys Gly Leu Glu Phe Gly Thr Thr Ser 210 215 220 Ser Glu Ser Asp Val Ser Asn Ala Tyr Pro Ile Gln Val Lys Leu Gly 225 230 235 240 Thr Gly Leu Thr Phe Asp Ser Thr Gly Ala Ile Val Ala Trp Asn Lys 245 250 255 Glu Asp Asp Lys Leu Thr Leu Trp Thr Thr Ala Asp Pro Ser Pro Asn 260 265 270 Cys Lys Ile Tyr Ser Glu Lys Asp Ala Lys Leu Thr Leu Cys Leu Thr 275 280 285 Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Thr Val Leu Ala Val Asn 290 295 300 Asn Gly Ser Leu Asn Pro Ile Thr Asn Thr Val Ser Thr Ala Ile Val 305 310 315 320 Tyr Leu Lys Phe Asp Ala Asn Gly Val Leu Leu Ser Asn Ser Thr Leu 325 330 335 Asn Lys Glu Tyr Trp Asn Phe Arg Lys Gly Asp Val Thr Pro Ala Glu 340 345 350 Ala Tyr Thr Asn Ala Ile Gly Phe Met Pro Asn Ile Lys Ala Tyr Pro 355 360 365 Lys Asn Thr Ser Ala Ala Ser Lys Ser His Ile Val Gly Gln Val Tyr 370 375 380 Leu Asn Gly Asp Glu Thr Lys Pro Leu Met Leu Ile Ile Thr Phe Asn 385 390 395 400 Glu Thr Asp Asp Ala Thr Cys Thr Tyr Cys Ile Thr Phe Gln Trp Lys 405 410 415 Trp Asp Asn Ser Lys Tyr Thr Gly Glu Thr Leu Ala Thr Ser Ser Phe 420 425 430 Pro Phe Ser Tyr Ile Ala Gln Glu 435 440 <210> 20 <211> 31740 <212> DNA <213> Unknown <220> <223> Simian adenovirus A1302 <220> <221> CDS <222> (1895)..(3409) <223> E1b\55K <220> <221> CDS <222> (25470)..(26021) <223> 22K <220> <221> CDS <222> (27325)..(27945) <223> E3\CR1-alpha <220> <221> CDS <222> (31313)..(31717) <223> E3\14.7K <400> 20 catcatcaat aatatacctc aaactttttg tgcgtgttaa tatgcaaatg aggcgtttga 60 atttggggct gcggggctgt gattggctgc gggagcggcg accgttaggg gcggggcggg 120 tgacgtttcg atgacgtgac gtgaggcgga gccggtttgc aagttctcgt gggaaaagtg 180 acgtcaaacg aggtgtggtt tgaacacgga aatactcaat tttcccgcgc tctctgacag 240 gaaatgaggt gtttctgggc ggatgcaagt gaaaacgggc cattttcgcg cgaaaactaa 300 atgaggaagt gaaaatctga gtaattccgc gtttatggca gggaggagta tttgccgagg 360 gccgagtaga ctttgaccga ttacgtgggg gtttcgatta ccgtattttt cacctaaatt 420 tccgcgtacg gtgtcaaagt ccggtgtttt tacgtaggcg tcagctgatc gccagggtat 480 ttaaacctgc gctctctagt caagaggcca ctcttgagtg ccagcgagta gagttttctc 540 ctccgcgccg cgagtcagat ctacactttg aaagatgagg cacctgagag acctgcccgg 600 taatgttttc ctggctactg ggaacgagat tctggaactg gtggtggacg ccatgatggg 660 tgacgaccct cctgagcccc ctaccccatt tgaggcgcct tcgctgtacg atttgtatga 720 tctggaggtg gatgtgcccg agaacgaccc caacgaggag gcggtgaatg atttgtttag 780 cgatgccgcg ctgctggctg ccgagcaggc taatacggac tctggctcag acagcgattc 840 ttctctccat accccgagac ctggcagagg tgagaaaaag attcccgagc ttaaagggga 900 agagctggac ctgcgctgct atgaggaatg cttgcctccg agcgatgatg aggaggacga 960 ggaggcgatc cgagctgcgg cgaaccaggg agtgaaagct gcgggcgaga gctttagcct 1020 ggactgtcct actctgcccg gacacggctg taagtcttgt gaatttcatc gcatgaatac 1080 tggagataag aatgtgatgt gtgccctgtg ctatatgaga gcttacaacc attgtgttta 1140 cagtaagtgt gattaacttt agttgggaag gcagagggtg actgggtgct gactggttta 1200 tttatgtata tgttttttta tgtgtaggtc ccgtctctga cgtagatgag acccccactt 1260 cagagtgcat ttcatcaccc ccagaaattg gcgaggaacc gcccgaagat attattcata 1320 gaccagttgc agtgagagtc accgggcgta gagcagctgt ggagagtttg gatgacttgc 1380 tacagggtgg ggatgaacct ttggacttgt gtacccggaa acgccccagg cactaagtgc 1440 cacacatgtg tgtttactta aggtgatgtc agtatttata gggtgtggag tgcaataaaa 1500 tccgtgttga ctttaagtgc gtggtttatg actcaggggt gggtatataa gcaggtgcag 1560 acctgtgtgg tcagttcaga gcaggactca tggagatctg gacggtcttg gaagactttc 1620 accagactag acagctgcta gagaactcat cggaggaagt ctcttacctg tggagatttt 1680 gcttcggtgg ggctctagct aagctagtcc atagggccaa acaggattat aaggatcaat 1740 ttgaggatat tttgagagag tgtcctggta tttttgactc tctcaacttg ggccatcagt 1800 ctcactttaa ccagagtatt ctgagagccc ttgacttttc tactcctggc agaactaccg 1860 ccgcggtagc cttttttgcc tttattcttg acaa atg gag tca aga aac cca ttt 1915 Met Glu Ser Arg Asn Pro Phe 1 5 cag cag gga tta ccg tct gga ctg ctt agc agt agc ttt gtg gag aac 1963 Gln Gln Gly Leu Pro Ser Gly Leu Leu Ser Ser Ser Phe Val Glu Asn 10 15 20 atg gag gtg cca gcg cct gaa tgc aat ctc cgg cta ctt gcc agt aca 2011 Met Glu Val Pro Ala Pro Glu Cys Asn Leu Arg Leu Leu Ala Ser Thr 25 30 35 gcc ggt aga cac gct gag gat cct gag tct cca gtc acc cca gga aca 2059 Ala Gly Arg His Ala Glu Asp Pro Glu Ser Pro Val Thr Pro Gly Thr 40 45 50 55 cca acg ccg cca gca gcc gca gca gga gca gca gca aga gga gga gga 2107 Pro Thr Pro Pro Ala Ala Ala Ala Gly Ala Ala Ala Arg Gly Gly Gly 60 65 70 gga gga ccg aga aga gaa ccc gag agc cgg tct gga ccc tcc ggt ggc 2155 Gly Gly Pro Arg Arg Glu Pro Glu Ser Arg Ser Gly Pro Ser Gly Gly 75 80 85 gga gga gga gga gta gct gac ttg ttt ccc gag ctg cgc cgg gtg ctg 2203 Gly Gly Gly Gly Val Ala Asp Leu Phe Pro Glu Leu Arg Arg Val Leu 90 95 100 act agg tct tcc agt gga cgg gag agg ggg att aag cgg gag agg cat 2251 Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly Ile Lys Arg Glu Arg His 105 110 115 gag gag act agt cac aga act gaa ctg act gtc agt ctg atg agc cgc 2299 Glu Glu Thr Ser His Arg Thr Glu Leu Thr Val Ser Leu Met Ser Arg 120 125 130 135 agg cgc cca gaa tcg gtg tgg tgg cat gag gtg cag tcg cag ggg ata 2347 Arg Arg Pro Glu Ser Val Trp Trp His Glu Val Gln Ser Gln Gly Ile 140 145 150 gat gag gtc tca gtg atg cat gag aaa tat tcc cta gaa caa gtc aag 2395 Asp Glu Val Ser Val Met His Glu Lys Tyr Ser Leu Glu Gln Val Lys 155 160 165 act tgt tgg ttg gag ccc gag gat gat tgg gag gta gcc atc agg aat 2443 Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp Glu Val Ala Ile Arg Asn 170 175 180 tat gcc aag ctg gct ctg aag cca gac aag aag tac aag att acc aaa 2491 Tyr Ala Lys Leu Ala Leu Lys Pro Asp Lys Lys Tyr Lys Ile Thr Lys 185 190 195 ctg att aat atc aga aat tcc tgc tac att tca ggg aat ggg gcc gag 2539 Leu Ile Asn Ile Arg Asn Ser Cys Tyr Ile Ser Gly Asn Gly Ala Glu 200 205 210 215 gtg gag atc agt acc cag gag agg gtg gcc ttc aga tgc tgc atg atg 2587 Val Glu Ile Ser Thr Gln Glu Arg Val Ala Phe Arg Cys Cys Met Met 220 225 230 aat atg tac ccg ggg gtg gtg ggc atg gag gga gtc acc ttt atg aac 2635 Asn Met Tyr Pro Gly Val Val Gly Met Glu Gly Val Thr Phe Met Asn 235 240 245 gcg agg ttc agg ggc gat ggg tat aat ggg gtg gtc ttt atg gcc aac 2683 Ala Arg Phe Arg Gly Asp Gly Tyr Asn Gly Val Val Phe Met Ala Asn 250 255 260 acc aag ctg aca gtg cac gga tgc tcc ttc ttt ggc ttc aat aac atg 2731 Thr Lys Leu Thr Val His Gly Cys Ser Phe Phe Gly Phe Asn Asn Met 265 270 275 tgc atc gag gcc tgg ggc agt gtt tca gtg agg gga tgc agc ttt tca 2779 Cys Ile Glu Ala Trp Gly Ser Val Ser Val Arg Gly Cys Ser Phe Ser 280 285 290 295 gcc aac tgg atg ggg gtc gtg ggc aga acc aag agc aag gtg tca gtg 2827 Ala Asn Trp Met Gly Val Val Gly Arg Thr Lys Ser Lys Val Ser Val 300 305 310 aag aaa tgc ctg ttc gag agg tgc cac atg ggg gtg atg agc gag ggc 2875 Lys Lys Cys Leu Phe Glu Arg Cys His Met Gly Val Met Ser Glu Gly 315 320 325 gaa gcc aaa gtc aaa cac tgc gcc tct acc gag acg ggc tgc ttt gtg 2923 Glu Ala Lys Val Lys His Cys Ala Ser Thr Glu Thr Gly Cys Phe Val 330 335 340 ctg atc aag ggc aat gcc caa gtc aag cat aac atg atc tgt ggg gcc 2971 Leu Ile Lys Gly Asn Ala Gln Val Lys His Asn Met Ile Cys Gly Ala 345 350 355 tcg gat gag cgc ggc tac cag atg ctg acc tgt gcc ggt ggg aac agc 3019 Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr Cys Ala Gly Gly Asn Ser 360 365 370 375 cat atg ctg gcc acc gtg cat gtg gcc tcg cac ccc cgc aag aca tgg 3067 His Met Leu Ala Thr Val His Val Ala Ser His Pro Arg Lys Thr Trp 380 385 390 ccc gag ttc gag cat aac gtc atg acc cgc tgc aat gtg cac ctg ggc 3115 Pro Glu Phe Glu His Asn Val Met Thr Arg Cys Asn Val His Leu Gly 395 400 405 tcc cgc cga ggc atg ttc atg ccc tac cag tgc aac atg caa ttt gtg 3163 Ser Arg Arg Gly Met Phe Met Pro Tyr Gln Cys Asn Met Gln Phe Val 410 415 420 aag gtg ctg ctg gag ccc gat gcc atg tcc aga gtg agt ctg acg ggg 3211 Lys Val Leu Leu Glu Pro Asp Ala Met Ser Arg Val Ser Leu Thr Gly 425 430 435 gtg ttt gac atg aat gtg gag atg tgg aaa att ctg aga tat gat gaa 3259 Val Phe Asp Met Asn Val Glu Met Trp Lys Ile Leu Arg Tyr Asp Glu 440 445 450 455 tcc aag acc agg tgc cgg gcc tgc gaa tgc gga ggc aaa cac gcc agg 3307 Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys Gly Gly Lys His Ala Arg 460 465 470 ctt cag ccc gtg tgt gtg gag gtg acg gag gac ctg cga ccc gat cat 3355 Leu Gln Pro Val Cys Val Glu Val Thr Glu Asp Leu Arg Pro Asp His 475 480 485 ttg gtg ttg tcc tgc aac ggg acg gag ttc ggc tcc agc ggg gaa gaa 3403 Leu Val Leu Ser Cys Asn Gly Thr Glu Phe Gly Ser Ser Gly Glu Glu 490 495 500 tct gac tagagtgagt agtgtttggg gctgggtggg agcctgcatg atgggcagaa 3459 Ser Asp 505 tgactaaaat ctgtgttttt ctgcgcagca tcatgagcgg aagcgcctcc tttgagggag 3519 gggtattcag cccttatctg acggggcgtc tcccctcctg ggcgggagtg cgtcagaatg 3579 tgatgggatc cacggtggac ggccggcccg tgcagcccgc gaactcttca accctgacct 3639 acgcgaccct gagctcctcg tccgtagacg cagctgccgc cgcagctgct gcttccgccg 3699 ccagcgccgt gcgcggaatg gccctgggcg ccggctacta cagctctctg gtggccaact 3759 cgagttccac caataatccc gccagcctga acgaggagaa gctgctgctg ctgatggccc 3819 agctcgaggc cctgacccag cgcctgggcg agctgaccca gcaggtggct cagctgcagg 3879 cggagacgcg ggccgcggtt gccacggtga aaaccaaata aaaaatgaat caataaataa 3939 acggagacgg ttgttgattt taacacagag tcttgaatct ttatttgatt tttcgcgcgc 3999 ggtaggccct ggaccaccgg tctcgatcat tgagcacccg gtggattttt tccaggaccc 4059 ggtagaggtg ggcttggatg ttgaggtaca tgggcatgag cccgtcccgg gggtggaggt 4119 agctccattg cagggcctcg tgctcggggg tggtgttgta aatcacccag tcatagcagg 4179 ggcgcagggc gtggtgctgc acgatgtcct tgaggaggag actgatggcc acgggcagcc 4239 ccttggtgta ggtgttgacg aacctgttga gctgggaggg atgcatgcgg ggggagatga 4299 gatgcatctt ggcctggatc ttgagattgg cgatgttccc gcccagatcc cgccgggggt 4359 tcatgttgtg caggaccacc agcacggtgt atccggtgca cttggggaat ttgtcatgca 4419 acttggaagg gaaggcgtga aagaatttgg agacgccctt gtgaccgccc aggttttcca 4479 tgcactcatc catgatgatg gcgatgggcc cgtgggcggc ggcctgggca aagacgtttc 4539 gggggtcgga cacatcgtag ttgtggtcct gggtgagctc gtcataggcc attttaatga 4599 atttggggcg gagggtgccc gactggggga caaaggtgcc ctcgatcccg ggggcgtagt 4659 ttccctcgca gatctgcatc tcccaggcct tgagctcgga gggggggatc atgtccacct 4719 gcggggcgat gaaaaaaacg gtttccgggg cgggggagat gagctgggcc gaaagcaggt 4779 tccggagcag ctgggacttg ccgcagccgg tggggccgta gatgaccccg atgaccggct 4839 gcaggtggta gttgagggag agacagctgc cgtcctcgcg gaggaggggg gccacctcgt 4899 tcatcatctc gcgcacatgc atgttctcgc gcacgagttc cgccaggagg cgctcgcccc 4959 ccagcgagag gagctcttgc agcgaggcga agtttttcag cggtttgagc ccgtcggcca 5019 tgggcatttt ggagagggtc tgttgcaaga gttccagacg gtcccagagc tcggtgatgt 5079 gctctagggc atctcgatcc agcagacctc ctcgtttcgc gggttggggc gactgcggga 5139 gtagggcacc aggcgatggg cgtccagcga ggccagggtc cggtccttcc aggggcgcag 5199 ggtccgcgtc agcgtggtct ccgtcacggt gaaggggtgc gcgccgggct gggcgcttgc 5259 gagggtgcgc ttcaggctca tccggctggt cgagaaccgc tcccggtcgg cgccctgcgc 5319 gtcggccagg tagcaattga gcatgagttc gtagttgagc gcctcggccg cgtggccctt 5379 ggcgcggagc ttacctttgg aagtgtgtcc gcagacggga cagaggaggg acttgagggc 5439 gtagagcttg ggggcgagga agacggactc gggggcgtag gcgtccgcgc cgcagctggc 5499 gcagacggtc tcgcactcca cgagccaggt gaggtcgggg cggtcggggt caaaaacgag 5559 gtttcctccg tgctttttga tgcgtttctt acctctggtc tccatgagct cgtgtccccg 5619 ctgggtgaca aagaggctgt ccgtgtcccc gtagaccgac tttatgggcc ggtcctcgag 5679 cggggtgccg cggtcctcgt cgtagaggaa ccccgcccac tccgagacga aggcccgggt 5739 ccaggccagc acgaaggagg ccacgtggga ggggtagcgg tcgttgtcca ccagcgggtc 5799 caccttctcc agggtatgca agcacatgtc cccctcgtcc acatccagga aggtgattgg 5859 cttgtaagtg taggccacgt gaccgggggt cccggccggg ggggtataaa agggggcggg 5919 cccctgctcg tcctcactgt cttccggatc gctgtccagg agcgccagct gttggggtag 5979 gtattccctc tcgaaggcgg gcatgacctc ggcactcagg ttgtcagttt ctagaaacga 6039 ggaggatttg atattgacgg tgccgttgga gacgcctttc atgagcccct cgtccatctg 6099 gtcagaaaag acgatctttt tgttgtcgag cttggtggcg aaggagccgt agagggcatt 6159 ggagaggagc ttggcgatgg agcgcatggt ctggttcttt tccttgtcgg cgcgctcctt 6219 ggcggcgatg ttgagctgca cgtactcgcg cgccacgcac ttccattcgg ggaagacggt 6279 ggtgagctcg tcgggcacga ttctgacccg ccagccgcgg ttgtgcaggg tgatgaggtc 6339 cacgctggtg gccacctcgc cgcgcagggg ctcgttggtc cagcagaggc gcccgccctt 6399 gcgcgagcag aaggggggca gcgggtccag catgagctcg tcgggggggt cggcgtccac 6459 ggtgaagatg ccgggcagga gctcggggtc gaagtagctg atgcaggtgc ccagatcgtc 6519 cagcgccgct tgccagtcgc gcacggccag cgcgcgctcg taggggctga ggggcgtgcc 6579 ccagggcatg gggtgcgtga gcgcggaggc gtacatgccg cagatgtcgt agacgtagag 6639 gggctcctcg aggacgccga tgtaggtggg gtagcagcgc cccccgcgga tgctggcgcg 6699 cacgtagtcg tacagctcgt gcgagggcgc gaggagcccc gcgccgaggt tggagcgctg 6759 cggcttttcg gcgcggtaga cgatctggcg gaagatggcg tgggagttgg aggagatggt 6819 gggcctctgg aagatgttga agtgggcgtg gggcaggccg accgagtccc tgatgaagtg 6879 ggcgtaggag tcctgcagct tggcgacgag ctcggcggtg acgaggacgt ccagggcgca 6939 gtagtcgagg gtctcttgga tgatgtcgta cttgagctgg cccttctgct tccacagctc 6999 gcggttgaga aggaactctt cgcggtcctt ccagtactct tcgaggggga acccgtcctg 7059 atcggcacgg taagagccca ccatgtagaa ctggttgacg gccttgtagg cgcagcagcc 7119 cttctccacg gggagggcat aagcttgcgc ggccttgcgc agggaggtgt gggtgagggc 7179 gaaggtgtcg cgcaccatga ccttgaggaa ctggtgcttg aagtcgaggt cgtcgcagcc 7239 gccctgctcc cagagttgga agtccgtgcg cttcttgtag gcggggttgg gcaaagcgaa 7299 agtaacatcg ttgaagagga tcttgcccgc gcggggcatg aagttgcgag tgatgcggaa 7359 aggctggggc acctcggccc ggttgttgat gacctgggcg gcgaggacga tctcgtcgaa 7419 gccgttgatg ttgtgcccga cgatgtagag ttccacgaat cgcgggcggc ccttgacgtg 7479 gggcagcttc ttgagctcgt cgtaggtgag ctcggcgggg tcgctgagtc cgtgctgctc 7539 aagggcccag tcggcgacgt gggggttggc gctgaggaag gaagtccaga gatccacggc 7599 cagggcggtt tgcaagcggt cccggtactg acggaactgc tggcccacgg ccattttttc 7659 gggggtgatg cagtagaagg tgcgggggtc gccgtgccag cggtcccact tgagctggag 7719 ggcgaggtcg tgggcgagct cgacgagcgg cgggtccccg gagagtttca tgaccagcat 7779 gaaggggacg agctgcttgc cgaaggaccc catccaggtg taggtttcca catcgtaggt 7839 gaggaagagc ctttcggtgc gaggatgcga gccgatgggg aagaactgga tctcctgcca 7899 ccagttggag gaatggctgt tgatgtgatg gaagtagaaa tgccgacggc gcgccgagca 7959 ctcgtgcttg tgtttataca agcgtccgca gtgctcgcaa cgctgcacgg gatgcacgtg 8019 ctgcacgagc tgtacctgag ttcctttgac gaggaatttc agtgggcagt ggagcgctgg 8079 cggctgcatc tggtgctgta ctacgtcctg gccatcggcg tggccatcgt ctgcctcgat 8139 ggtggtcatg ctgacgagcc cgcgcgggag gcaggtccag acctcgactc ggacgggtcg 8199 gagagcgagg acgagggcgc gcaggccgga gctgtccagg gtcctgagac gctgcggagt 8259 caggtcagtg ggcagcggcg gcgcgcggtt gacttgcagg agcttttcca gggcgcgcgg 8319 gaggtccaga tggtacttga tctccacggc gccgttggtg gcgacgtcca cggcttgcag 8379 ggtcccgtgc ccctggggcg ccaccaccgt gccccgtttc ttcttgggcg ctggcgttgg 8439 cgctgcttcc atgtcggtca gaagcggcgg cgaggacgcg cgccgggcgg caggggcggc 8499 tcggggcccg gaggcagggg cggcaggggc acgtcggcgc cgcgcgcggg caggttctgg 8559 tactgcgccc ggagaagact ggcgtgagcg acgacgcgac ggttgacgtc ctggatctga 8619 cgcctctggg tgaaggccac gggacccgtg agtttgaacc tgaaagagag ttcgacagaa 8679 tcaatctcgg tatcgttgac ggcggcctgc cgcaggatct cttgcacgtc gcccgagttg 8739 tcctggtagg cgatctcggt catgaactgc tcgatctcct cctcctgaag gtctccgcgg 8799 ccggcgcgct ccacggtggc cgcgaggtcg ttggagatgc ggcccatgag ctgcgagaag 8859 gcgttcatgc ccgcctcgtt ccagacgcgg ctgtagacca cgacgccctc gggatcgcgg 8919 gcgcgcatga ccacctgggc gaggttgagc tccacgtggc gcgtgaagac cgcgtagttg 8979 cagaggcgct ggtagaggta gttgagcgtg gtggcgatgt gctcggtgac gaagaaatac 9039 atgatccagc ggcggagcgg catctcgctg acgtcgccca gcgcctccaa gcgttccatg 9099 gcctcgtaaa agtccacggc gaagttgaaa aactgggagt tgcgcgccga gacggtcaac 9159 tcctcctcca gaagacggat gagctcggcg atggtggcgc gcacctcgcg ctcgaaggcc 9219 cccgggagtt cctccacttc ctcttcttct tcctcctcca ctaacatctc ttctacttcc 9279 tcctcaggcg gtggtggcgg gggagggggc ctgcgtcgcc ggcggcgcac gggcagacgg 9339 tcgatgaagc gctcgatggt ctcgccgcgc cggcgtcgca tggtctcggt gacggcgcgc 9399 ccgtcctcgc ggggccgcag cgtgaagacg ccgccgcgca tctccaggtg gccggggggg 9459 tccccgttgg gcagggagag ggcgctgacg atgcatctta tcaattgccc cgtagggact 9519 ccgcgcaagg acctgagcgt ctcgagatcc acgggatctg aaaaccgttg aacgaaggct 9579 tcgagccagt cgcagtcgca aggtaggctg agcacggttt cttctggcgg gtcatgttgg 9639 ttggagggag cggggcgggc gatgctgctg gtgatgaagt tgaaataggc ggttctgaga 9699 cggcggatgg tggcgaggag caccaggtct ttgggcccgg cttgctggat gcgcagacgg 9759 tcggccatgc cccaggcgtg gtcctgacac ctggccaggt ccttgtagta gtcctgcatg 9819 agccgctcca cgggcacctc ctcctcgccc gcgcggccgt gcatgcgcgt gagcccgaac 9879 ccgcgctgcg gctggacgag cgccaggtcg gcgacgacgc gctcggcgag gatggcctgc 9939 tggatctggg tgagggtggt ctggaagtcg tcaaagtcga cgaagcggtg gtaggctccg 9999 gtgttgatgg tgtaggagca gttggccatg acggaccagt tgacggtctg gtggcccgga 10059 cgcacgagct cgtggtactt gaggcgcgag taggcgcgcg tgtcgaagat gtagtcgttg 10119 caggtgcgca ccaggtattg gtagccgatg aggaagtgcg gcggcggctg gcggtagagc 10179 ggccatcgct cggtggcggg ggcgccgggc gcgaggtcct cgagcatgag gcggtggtag 10239 ccgtagatgt acctggacat ccaggtgatg ccggcggcgg tggtggaggc gcgcgggaac 10299 tcgcggacgc ggttccagat gttgcgcagc ggcaggaagt agttcatggt ggccgcggtc 10359 tggcccgtga ggcgcgcgca gtcgtggatg ctctagacat acgggcaaaa acgaaagcgg 10419 tcagcggctc gactccgtgg cctggaggct aagcgaacgg gttgggctgc gcgtgtaccc 10479 cggttcgaat ctcgaatcag gctggagccg cagctaacgt ggtactggca ctcccgtctc 10539 gacccaagcc tgctaacgaa acctccagga tacggaggcg ggtcgttttg gcatttttcg 10599 tcaggccgga aatgaaacta gtaagcgcgg aaagcggccg accgcgatgg ctcgctgccg 10659 tagtctggag aagaatcgcc agggttgcgt tgcggtgtgc cccggttcga ggccggccgg 10719 attccgcggc taacgagggc gtggctgccc cgtcgtttcc aagaccccta gccagccgac 10779 ttctccagtt acggagcgag cccctctttt gttttttgtt tttgccagat gcatcccgta 10839 ctgcggcaga tgcgccccca ccaccctcca ccgcaacaac agccccctcc acagccggcg 10899 cttctgcccc cgccccagca gcagcagcaa cttccagcca cgaccgccgc ggccgccgtg 10959 agcggggctg gacagagtta tgaccaccag ctggccttgg aagagggcga ggggctggcg 11019 cggctggggg cgtcgtcgcc ggagcggcac ccgcgcgtgc agatgaaaag ggacgctcgc 11079 gaggcctacg tgcccaagca gaacctgttc agagacagga gcggcgagga gcccgaggag 11139 atgcgcgcct cccgcttcca cgcggggcgg gagctgcggc gcggcctgga ccgaaagcgg 11199 gtgctgaggg acgaggattt cgaggcggac gagctgacgg ggatcagccc cgcgcgcgcg 11259 cacgtggccg cggccaacct ggtcacggcg tacgagcaga ccgtgaagga ggagagcaac 11319 ttccaaaaat ccttcaacaa ccacgtgcgc accttgatcg cgcgcgagga ggtgaccctg 11379 ggcctgatgc acctgtggga cctgctggag gccatcgtgc agaaccccac gagcaagccg 11439 ctgacggcgc agctgtttct ggtggtgcag cacagtcggg acaacgagac gttcagggag 11499 gcgctgctga atatcaccga gcccgagggc cgttggctcc tggacctggt gaacattctg 11559 cagagcatcg tggtgcagga gcgcgggctg ccgctgtccg agaagctggc ggccatcaac 11619 ttctcggtgc tgagcctggg caagtactac gctaggaaga tctacaagac cccgtacgtg 11679 cccatagaca aggaggtgaa gatcgatggg ttttacatgc gcatgaccct gaaagtgctg 11739 accctgagcg acgatctggg ggtgtaccgc aacgacagga tgcaccgcgc ggtgagcgcc 11799 agccgccggc gcgagctgag cgaccaggag ctgatgcaca gcctgcagcg ggccctgacc 11859 ggggccggga ccgaggggga gagctacttt gacatgggcg cggacctgcg ctggcagccc 11919 agccgccggg ccttggaagc tgccggcggc gtgccctacg tggaggaggt ggacgatgag 11979 gaggaggagg gcgagtacct ggaagactga tggcgcgacc gtatttttgc tagatgcagc 12039 aacagccacc gcctcctgat cccgcgatgc gggcggcgct gcagagccag ccgtccggca 12099 ttaactcctc ggacgattgg acccaggcca tgcaacgcat catggcgctg acgacccgca 12159 atcccgaagc ctttagacag cagcctcagg ccaaccggct ctcggccatc ctggaggccg 12219 tggtgccctc gcgctcgaac cccacgcacg agaaggtgct ggccatcgtg aacgcgctgg 12279 tggagaacaa ggccatccgc ggcgacgagg ccgggctggt gtacaacgcg ctgctggagc 12339 gcgtggcccg ctacaacagc accaacgtgc agacgaacct ggaccgcatg gtgaccgacg 12399 tgcgcgaggc ggtgtcgcag cgcgagcggt tccaccgcga gtcgaacctg ggctccatgg 12459 tggcgctgaa cgccttcctg agcacgcagc ccgccaacgt gccccggggc caggaggact 12519 acaccaactt catcagcgcg ctgcggctga tggtggccga ggtgccccag agcgaggtgt 12579 accagtcggg gccggactac ttcttccaga ccagtcgcca gggcttgcag accgtgaacc 12639 tgagccaggc tttcaagaac ttgcagggac tgtggggcgt gcaggccccg gtcggggacc 12699 gcgcgacggt gtcgagcctg ctgacgccga actcgcgcct gctgctgctg ctggtggcgc 12759 ccttcacgga cagcggcagc gtgagccgcg actcgtacct gggctacctg cttaacctgt 12819 accgcgaggc catcgggcag gcgcacgtgg acgagcagac ctaccaggag atcacccacg 12879 tgagccgcgc gctggggcag gaggacccgg gcaacctgga ggccaccctg aacttcctgc 12939 tgaccaaccg gtcgcagaag atcccgcccc agtacgcgct gagcaccgag gaggagcgca 12999 tcctgcgcta cgtgcagcag agcgtggggc tgttcctgat gcaggagggg gccacgccca 13059 gcgccgcgct cgacatgacc gcgcgcaaca tggagcccag catgtacgcc cgcaaccgcc 13119 cgttcatcaa taagctgatg gactacttgc atcgggcggc cgccatgaac tcggactact 13179 ttaccaacgc catcttgaac ccgcactggc tcccgccgcc cgggttctac acgggcgagt 13239 acgacatgcc cgaccccaac gacgggttcc tgtgggacga cgtggacagc agcgtgttct 13299 cgccgcgccc caccaccacc gtgtggaaga aagagggcgg ggaccggcgg ccgtcctcgg 13359 cgctgtccgg tcgcgcgggt gctgccgcgg cggtgcccga ggccgccagc cccttcccga 13419 gcctgccctt ttcgctgaac agcgtgcgca gcagcgagct gggtcggctg acgcggccgc 13479 gcctgctggg cgaggaggag tacctgaacg actccttgtt gaggcccgag cgcgagaaaa 13539 acttccccaa taacgggata gagagcctgg tggacaagat gagccgctgg aagacgtacg 13599 cgcacgagca cagggacgag ccccgagcta gcagcagcac cggcgcccgt agacgccagc 13659 ggcacgacag gcagcgggga ctggtgtggg acgatgagga ttccgccgac gacagcagcg 13719 tgttggactt gggtgggagt ggtggtggta acccgttcgc tcacctgcgc ccccgtatcg 13779 ggcgcctgat gtaagaatct gaaaaaataa aaaaacggta ctcaccaagg ccatggcgac 13839 cagcgtgcgt tcttctctgt tgtttgtagt agtatgatga ggcgcgtgta cccggagggt 13899 cctcctccct cgtacgagag cgtgatgcag caggcggtgg cggcggcgat gcagcccccg 13959 ctggaggcgc cttacgtgcc cccgcggtac ctggcgccta cggaggggcg gaacagcatt 14019 cgttactcgg agctggcacc cttgtacgat accacccggt tgtacctggt ggacaacaag 14079 tcggcggaca tcgcctcgct gaactaccag aacgaccaca gcaacttcct gaccaccgtg 14139 gtgcagaaca acgatttcac ccccacggag gccagcaccc agaccatcaa ctttgacgag 14199 cgctcgcggt ggggcggcca gctgaaaacc atcatgcaca ccaacatgcc caacgtgaac 14259 gagttcatgt acagcaacaa gttcaaggcg cgggtgatgg tctcgcgcaa gacccccaac 14319 ggggtcacag taacagatgg tagtcaggac gagctgacct acgagtgggt ggagtttgag 14379 ctgcccgagg gcaacttctc ggtgaccatg accatcgatc tgatgaacaa cgccatcatc 14439 gacaactact tggcggtggg acggcagaac ggggtgctgg agagcgacat cggcgtgaag 14499 ttcgacacgc gcaacttccg gctgggctgg gaccccgtga ccgagctggt gatgccgggc 14559 gtgtacacca acgaggcctt ccaccccgac attgtcctgc tgcccggctg cggcgtggac 14619 ttcaccgaga gccgcctcag caacctgctg ggcatccgca agcggcagcc cttccaggag 14679 ggcttccaga tcctgtacga ggacctggag gggggcaaca tccccgcgct gctggacgtg 14739 gacgcctacg agaaaagcaa ggaggagagc gccgccgcgg cgaccgcagc cgtggccacc 14799 gcctctaccg aggtgcgggg cgataatttt gctagcgccg cggcagtggc cgaggcggct 14859 gaaaccgaaa gtaagatagt gatccagccg gtggagaagg acagcaagga caggagctac 14919 aacgtgctcg cggacaagaa aaacaccgcc taccgcagct ggtacctggc ctacaactac 14979 ggcgaccccg agaagggcgt gcgctcctgg acgctgctca ccacctcgga cgtcacctgc 15039 ggcgtggagc aagtctactg gtcgctgccc gacatgatgc aagacccggt caccttccgc 15099 tccacgcgac aagttagcaa ctacccggtg gtgggcgccg agctcctgcc cgtctactcc 15159 aagagcttct tcaacgagca ggccgtctac tcgcagcagc tgcgcgcctt cacctcgctc 15219 acgcacgtct tcaaccgctt ccccgagaac cagatcctcg tccgcccgcc cgcgcccacc 15279 attaccaccg tcagtgaaaa cgttcctgct ctcacagatc acgggaccct gccgctgcgc 15339 agcagtatcc ggggagtcca gcgcgtgacc gtcactgacg ccagacgccg cacctgcccc 15399 tacgtctaca aggccctggg cgtagtcgcg ccgcgcgtcc tctcgagccg caccttctaa 15459 aaaatgtcca ttctcatctc gcccagtaat aacaccggtt ggggcctgcg cgcgcccagc 15519 aagatgtacg gaggcgctcg ccaacgctcc acgcaacacc ccgtgcgcgt gcgcgggcac 15579 ttccgcgctc cctggggcgc cctcaagggt cgcgtgcgct cgcgcaccac cgtcgacgac 15639 gtgatcgacc aggtggtggc cgacgcgcgc aactacacgc ccgccgccgc gcccgcctcc 15699 accgtggacg ccgtcatcga cagcgtggtg gccgacgcgc gccggtacgc ccgcgccaag 15759 agccggcggc ggcgcatcgc ccggcggcac cggagcaccc ccgccatgcg cgcggcgcga 15819 gccttgctgc gcagggccag gcgcacggga cgcagggcca tgctcagggc ggccagacgc 15879 gcggcctccg gcagcagcag cgccggcagg acccgcagac gcgcggccac ggcggcggcg 15939 gcggccatcg ccagcatgtc ccgcccgcgg cgcggcaacg tgtactgggt gcgcgacgcc 15999 gccaccggtg tgcgcgtgcc cgtgcgcacc cgcccccctc gcacttgaag atgctgactt 16059 cgcgatgttg atgtgtccca gcggcgagga ggatgtccaa gcgcaaattc aaggaagaga 16119 tgctccaggt catcgcgcct gagatctacg gccccgcggc ggcggtgaag gaggaaagaa 16179 agccccgcaa actgaagcgg gtcaaaaagg acaaaaagga agaagatgtg gacgatatgg 16239 tggagtttgt gcgcgagttc gccccccggc ggcgcgtgca gtggcgcggg cggaaggtgc 16299 gcccggtgct gagacccggc accacggtgg tcttcacgcc cggagagcgc tctggcaccg 16359 cctccaagcg ctcctacgac gaggtgtacg gggatgatga tattctggag caggcggccg 16419 agcgcctggg cgagtttgct tacggcaagc gcagccgccc cgcgcccttg aaagaggagg 16479 cggtgtccat cccgctggac cacggcaacc ccacgccgag cctgaagccg gtgaccctgc 16539 agcaggtgct gccagccgcg gcgccgcgcc gggggttcaa gcgcgagggc gaggatctgt 16599 accccaccat gcagctgatg gtgcccaagc gccagaagct ggaggacgtg ctggagcaca 16659 tgaaggtgga cccggacgtg cagcccgagg tcaaggtgcg gcccatcaag caggtggccc 16719 cgggcctggg cgtgcagacc gtggacatca agatccccac ggagcccatg gaaacgcaga 16779 ctgagcccgt gaagcccagc accagcacca tggaggtgca gacggatccc tggatgccag 16839 cggcttccac caccactcgc cgaagacgca agtacggcgc ggccagcctg ctgatgccca 16899 actacgcgct gcatccttcc atcatcccca cgccgggcta ccgcggcacg cgcttctacc 16959 gcggctacac cagcagccgc cgccgcaaga ccaccacccg ccgccgccgt cgtcgcagcc 17019 gccgcagcag caccgcgact tccgccttgg tgcggagagt gtaccgcagc gggcgcgagc 17079 ctctgaccct gccgcgcgcg cgctaccacc cgagcatcgc catttaacta ccgcctccta 17139 cttgcagata tggccctcac atgccgcctc cgcgtcccca ttacgggcta ccgaggaaga 17199 aagccgcgcc gtagaaggct gacggggaac gggctgcgtc gccatcacca ccggcggcgg 17259 cgcgccatca gcaagcggtt ggggggaggc ttcctgcccg cgctgatccc catcatcgcc 17319 gcggcgatcg gggcgatccc cggcatagct tccgtggcgg tgcaggcctc tcagcgccac 17379 tgagacacag cttggaaaat ttgtaataaa aaatggactg acgctcctgg tcctgtgatg 17439 tgtgttttta gatggaagac atcaattttt cgtccctggc accgcgacac ggcacgcggc 17499 cgtttatggg cacctggagc gacatcggca acagccaact gaacgggggc gccttcaatt 17559 ggagcagtct ctggagcggg cttaagaatt tcgggtccac gctcaaaacc tatggcaaca 17619 aggcgtggaa cagcagcaca gggcaggcgc tgagggaaaa gctgaaagag cagaacttcc 17679 agcagaaggt ggtcgatggc ctggcctcgg gcatcaacgg ggtggtggac ctggccaacc 17739 aggccgtgca gaaacagatc aacagccgcc tggacgcggt cccgcccgcg gggtccgtgg 17799 acatgcccca ggtggaggag gagctgcctc ccctggacaa gcgcggcgac aagcgaccgc 17859 gtcccgacgc tgaggagacg ctgctgacgc acacggacga gccgcccccg tacgaggagg 17919 cggtgaaact gggtctgccc accacgcggc ccgtggcgcc tctggccacc ggggtgctga 17979 aacccagcag cagcagcagc cagcccgcga ccctggactt gcctccacct cgcccctcca 18039 cagtggctaa gcccctgccg ccggtggccg tcgcgtcgcg cgccccccga ggccgccccc 18099 aggcgaactg gcagagcact ctgaacagca tcgtgggtct gggagtgcag agtgtgaagc 18159 gccgccgctg ctattaaaag acactgtagc gcttaacttg cttgtctgtg tgtgtatatg 18219 tatgtccgcc gaccagaagg aggaagaggc gcgtcgccga gttgcaagat ggccacccca 18279 tcgatgctgc cccagtgggc gtacatgcac atcgccggac aggacgcttc ggagtacctg 18339 agtccgggtc tggtgcagtt cgcccgcgcc acagacacct acttcagtct ggggaacaag 18399 tttaggaacc ccacggtggc gcccacgcac gatgtgacca ccgaccgcag ccagcggctg 18459 acgctgcgct tcgtgcccgt ggaccgcgag gacaacacct actcgtacaa agtgcgctac 18519 acgctggccg tgggcgacaa ccgcgtgctg gacatggcca gcacctactt tgacatccgc 18579 ggcgtgctgg atcggggccc cagcttcaaa ccctactccg gcaccgccta caacagcctg 18639 gctcccaagg gagcgcccaa cacctcacaa tggataacca aagacaagac atacagtttt 18699 ggaaatgctc cagtcagagg attggacatt acagaagagg gtctccaaat agtaaccgat 18759 gagtcagggg gtgaaagcaa gaaaattttt gcagacaaaa cctatcagcc tgaacctcag 18819 cttggagatg aggaatggca tgatactatt ggagctgaag acaagtatgg aggcagagcg 18879 cttaaacctg ccaccaacat gaaaccctgc tatgggtctt tcgccaagcc aactaatgct 18939 aagggaggtc aggctaaaag cagaaccaag gacgatggca ctactgagcc tgatattgac 18999 atggcctttt ttgacgatcg cagtcagcaa gctagtttca gtccagaact tgttttgtat 19059 actgagaatg tcgatctgga caccccggat acccacatta tttacaaacc tggcactgat 19119 gaaacaagtt cttctttcaa cttgggtcag cagtccatgc ccaacagacc caattacatt 19179 ggcttcagag acaactttat cggactcatg tactacaaca gcactggcaa tatgggtgta 19239 ctggctggac aggcctccca gctgaatgct gtggtggact tgcaggacag aaacaccgaa 19299 ctgtcctacc agctcttgct tgactctctg ggcgacagaa ccaggtattt cagtatgtgg 19359 aatcaggcgg tggacagcta tgaccccgat gtgcgcatta ttgaaaatca cggtgtggag 19419 gatgaacttc ccaactattg cttccctttg aatggtgtgg gctttacaga ttcattccag 19479 ggaattaagg ttaaaactac caataacgga acagcaaacg ctacagagtg ggaatctgat 19539 acctctgtca ataatgctaa tgagattgcc aagggcaatc ctttcgccat ggagatcaac 19599 atccaggcca acctgtggcg gaacttcctc tacgcgaacg tggcgctgta cctgcccgac 19659 tcctacaagt acacgccggc caacatcacg ctgcccacca acaccaacac ctacgattac 19719 atgaacggcc gcgtggtggc gccctcgctg gtggacgcct acatcaacat cggggcgcgc 19779 tggtcgctgg accccatgga caacgtcaac cccttcaacc accaccgcaa cgcgggcctg 19839 cgataccgct ccatgctcct gggcaacggg cgctacgtgc ccttccacat ccaggtgccc 19899 caaaagtttt tcgccatcaa gagcctcctg ctcctgcccg ggtcctacac ctacgagtgg 19959 aacttccgca aggacgtcaa catgatcctg cagagctccc tcggcaacga cctgcgcacg 20019 gacggggcct ccatctcctt caccagcatc aacctctacg ccaccttctt ccccatggcg 20079 cacaacacgg cctccacgct cgaggccatg ctgcgcaacg acaccaacga ccagtccttc 20139 aacgactacc tctcggcggc caacatgctc taccccatcc cggccaacgc caccaacgtg 20199 cccatctcca tcccctcgcg caactgggcc gccttccgcg gctggtcctt cacgcgtctc 20259 aagaccaagg agacgccctc gctgggctcc gggttcgacc cctacttcgt ctactcgggc 20319 tccatcccct acctcgacgg caccttctac ctcaaccaca ccttcaagaa ggtctccatc 20379 accttcgact cctccgtcag ctggcccggc aacgaccgcc tcctgacgcc caacgagttc 20439 gaaatcaagc gcaccgtcga cggagagggg tacaacgtgg cccagtgcaa catgaccaag 20499 gactggttcc tggtccagat gctggcccac tacaacatcg gctaccaggg cttctacgtg 20559 cccgagggct acaaggaccg catgtactcc ttcttccgca acttccagcc catgagccgc 20619 caggtcgtgg acgaggtcaa ctacaaggac taccaggccg tcaccctggc ctaccagcac 20679 aacaactcgg gcttcgtcgg ctacctcgcg cccaccatgc gccaggggca gccctacccc 20739 gccaactacc cgtacccgct catcggcaag agcgccgtca ccagcgtcac ccagaaaaag 20799 ttcctctgcg accgggtcat gtggcgcatc cccttctcca gcaacttcat gtccatgggc 20859 gcgctcaccg acctcggcca gaacatgctc tatgccaact ccgcccacgc gctagacatg 20919 aatttcgaag tcgaccccat ggatgagtcc acccttctct atgttgtctt cgaagtcttc 20979 gacgtcgtcc gagtgcacca gccccaccgc ggcgtcatcg aggccgtcta cctgcgcacc 21039 cccttctcgg ccggtaacgc caccacctaa gctcttgctt cttgcatgat ggctgagccc 21099 acgggctccg gcgagcagga gctcagggcc atcatccgcg acctgggctg cgggccctac 21159 ttcctgggca ccttcgataa gcgcttcccg ggattcatgg ccccgcacaa gctggcctgc 21219 gccatcgtca acacggccgg tcgcgagacc gggggcgagc actggctggc cttcgcctgg 21279 aacccgcgct cgaacacctg ctacctcttc gaccccttcg ggttctcgga cgagcgcctc 21339 aagcagatct accagttcga gtacgagggc ctgctgcgcc gcagcgccct ggccaccgag 21399 gaccgctgcg tcaccctgga aaagtccacc cagaccgtgc agggtccgcg ctcggccgcc 21459 tgcgggctct tctgctgcat gttcctgcac gccttcgtgc actggcccga ccgccccatg 21519 gacaagaacc ccaccatgaa cttgctgacg ggggtgccca acggcatgct ccagtcgccc 21579 caggtggaac ccaccctgcg ccgcaaccag gaggcgctct accgcttcct caacgcccac 21639 tccgcctact ttcgctccca ccgcgcgcgc atcgagaagg ccaccgcctt cgaccgcatg 21699 aatcaagaca tgtaaaccgt gtgtgtatgt gaatgcttta ttcataataa acagcacatg 21759 tttatgccac cttctctgag gctctgactt tatttagaaa tcgaaggggt tctgccggct 21819 ctcggcgtgc cccgcgggca gggatacgtt gcggaactgg tacttgggca gccacttgaa 21879 ctcggggatc agcagcttcg gcacggggag gtcggggaac gagtcgctcc acagcttgcg 21939 cgtgagttgc agggcgccca gcaggtcggg cgcggagatc ttgaaatcgc agttgggacc 21999 cgcgttctgc gcgcgagagt tgcggtacac ggggttgcag cactggaaca ccatcagggc 22059 cgggtgcttc acgctcgcca gcaccgtcgc gtcggtgatg ccctccacgt ccagatcctc 22119 ggcgttggcc atcccgaagg gggtcatctt gcaggtctgc cgccccatgc tgggcacgca 22179 gccgggcttg tggttgcaat cgcagtgcag ggggatcagc atcatctggg cctgctcgga 22239 gctcatgccc gggtacatgg ccttcatgaa agcctccagc tggcggaagg cctgctgcgc 22299 cttgccgccc tcggtgaaga agaccccgca ggacttgcta gagaactggt tggtagcgca 22359 gcccgcgtcg tgcacgcagc agcgcgcgtc gttgttggcc agctgcacca cgctgcgccc 22419 ccagcggttc tgggtgatct tggcccggtc ggggttctcc ttcagcgcgc gctgcccgtt 22479 ctcgctcgcc acatccatct cgatcgtgtg ctccttctgg atcatcacgg tcccgtgcag 22539 gcaccgcagc ttgccctcgg cctcggtgca gccgtgcagc cacagcgcgc agccggtgct 22599 ctcccagttc ttgtgggcga tctgggagtg cgagtgcacg aagccctgca ggaagcggcc 22659 catcatcgcg gtcagggtct tgttgctggt gaaggtcagc gggatgccgc ggtgctcctc 22719 gttcacatac aggtggcaga tgcggcggta cacctcgccc tgctcgggca tcagctggaa 22779 ggcggacttc aggtcgctct ccacgcggta ccgctccatc agcagcgtca tcacttccat 22839 gcccttctcc caggccgaaa cgatcggcag gctcaggggg ttcttcaccg tcatcttagt 22899 cgccgccgcc gaggtcaggg ggtcgttctc gtccagggtc tcaaacactc gcttgccgtc 22959 cttctcggtg atgcgcacgg gggggaaggc gaagcccacg gccgccagct cctcctcggc 23019 ctgcctttcg tcctcgctgt cctggctgat gtcttgcaaa ggcacatgct tggtcttgcg 23079 gggtttcttt ttgggcggca gaggcggcgg cggagacgtg ctgggcgagc gcgagttctc 23139 gctcaccacg actatttctt cttcttggcc gtcgtccgag accacgcggc ggtaggcatg 23199 cctcttctgg ggcagaggcg gaggcgacgg gctctcgcgg ttcgacgggc ggctggcaga 23259 gccccttccg cgttcggggg tgcgctcctg gcggcgctgc tctgactgac ttcctccgcg 23319 gccggccatt gtgttctcct agggagcaac aagcatggag actcagccat cgtcgccaac 23379 atcgccatct gcccccgccg ccgccgacga gaaccagcag cagcagaatg aaagcttaac 23439 cgccccgccg cccagcccca cctccgacgc cgccgcagcc ccagacatgc aagagatgga 23499 ggaatccatc gagattgacc tgggctacgt gacgcccgcg gagcacgagg aggagctggc 23559 agcgcgcttt tcagccccgg aagagaacca ccaagagcag ccagagcagg aagcagagag 23619 cgagcagcag caggctgggc tcgagcatgg cgactacctg agcggggcag aggacgtgct 23679 catcaagcat ctggcccgcc aatgcatcat cgtcaaggac gcgctgctcg accgcgccga 23739 ggtgcccctc agcgtggcgg agctcagccg cgcctacgag cgcaacctct tctcgccgcg 23799 cgtgcccccc aagcgccagc ccaacggcac ctgcgagccc aacccgcgcc tcaacttcta 23859 cccggtcttc gcggtgcccg aggccctggc cacctaccac ctctttttca agaaccaaag 23919 gatccccgtc tcctgccgcg ccaaccgcac ccgcgccgac gccctgctca acctgggccc 23979 cggcgcccgc ctacctgata tcgcctcctt ggaagaggtt cccaagatct tcgagggtct 24039 gggcagcgac gagactcggg ccgcgaacgc tctgcaagga agcggagagg agcatgagca 24099 ccacagcgcc ctggtggagt tggaaggcga caacgcgcgc ctggcggtcc tcaagcgcac 24159 ggtcgagctg acccacttcg cctacccagc gctcaacctg ccccccaagg tcatgagcgc 24219 cgtcatggac caggtgctca tcaagcgcgc ctcgcccctc tcggaggagg agatgcagga 24279 ccccgagagc tcggacgagg gcaagcccgt ggtcagcgac gagcagctgg cgcgctggct 24339 gggagcgagt agcacccccc agagcctgga agagcggcgc aagctcatga tggccgtggt 24399 cctggtgacc gtggagctgg agtgtctgcg ccgcttcttt gccgacgcgg agaccctgcg 24459 caaggtcgag gagaacctgc actacctctt caggcacggg ttcgtgcgcc aggcctgcaa 24519 gatctccaac gtggagctga ccaacctggt ctcctacatg ggcatcctgc acgagaaccg 24579 cctggggcag aacgtgctgc acaccaccct gcgcggggag gcccgccgcg actacatccg 24639 cgactgcgtc tacctgtacc tctgccacac ctggcagacg ggcatgggcg tgtggcagca 24699 gtgcctggag gagcagaacc tgaaagagct ctgcaagctc ctgcagaaga acctcaaggc 24759 cctgtggacc gggttcgacg agcgcaccac cgcctcggac ctggccgacc tcatcttccc 24819 cgagcgcctg cggctgacgc tgcgcaacgg gctgcccgac tttatgagcc aaagcatgtt 24879 gcaaaacttt cgctctttca tcctcgaacg ctccgggatc ctgcccgcca cctgctccgc 24939 actgccctcg gacttcgtgc cgctgacctt ccgcgagtgc cccccgccgc tctggagcca 24999 ctgctacctg ctgcgcctgg ccaactacct ggcctaccac tcggacgtga tcgaggacgt 25059 cagcggcgag ggtctgctcg agtgccactg ccgctgcaac ctctgcacgc cgcaccgctc 25119 cctggcctgc aacccccagc tgctgagcga gacccagatc atcggcacct tcgagttgca 25179 agggcccggt gacggcaagg ggggtctgaa actcaccccg gggctgtgga cctcggccta 25239 cttgcgcaag ttcgtgcccg aggactacca tcccttcgag atcaggttct acgaggacca 25299 atcccagccg cccaaggccg agctgtcggc ctgcgtcatc acccaggggg ccatcctggc 25359 ccaattgcaa gccatccaga aatcccgcca agaatttctg ctgaaaaagg gccacggggt 25419 ctacctggac ccccagaccg gagaggagct caaccccagc ttcccccagg atg ccc 25475 Met Pro cga gga agc agc aag aag ctg aaa gtg gag ctg ccg ccg gag gat ttg 25523 Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Pro Glu Asp Leu 510 515 520 gag gaa gac tgg gag agc agt cag gca gag gag atg gaa gac tgg gac 25571 Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Met Glu Asp Trp Asp 525 530 535 agc act cag gca gag gag gac agc ctg caa gac agt ctg gaa gac gag 25619 Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser Leu Glu Asp Glu 540 545 550 555 gtg gag gag gag gca gag gaa gaa gca gcc gcc gcc aga ccg tcg tcc 25667 Val Glu Glu Glu Ala Glu Glu Glu Ala Ala Ala Ala Arg Pro Ser Ser 560 565 570 tcg gcg gag gag gag aaa gca agc agc acg gat acc atc tcc gct ccg 25715 Ser Ala Glu Glu Glu Lys Ala Ser Ser Thr Asp Thr Ile Ser Ala Pro 575 580 585 ggt crg ggt cgc ggc ggc cgg gcc cac agt agg tgg gac gag acc ggg 25763 Gly Xaa Gly Arg Gly Gly Arg Ala His Ser Arg Trp Asp Glu Thr Gly 590 595 600 cgc ttc ccg aac ccc acc acc cag acc ggt aag aag gag cgg cag gga 25811 Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys Glu Arg Gln Gly 605 610 615 tac aag tcc tgg cgg ggg cac aaa aac gcc atc gtc tcc tgc ttg caa 25859 Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser Cys Leu Gln 620 625 630 635 gcc tgc ggg ggc aac atc tcc ttc acc cgg cgc tac ctg ctc ttc cac 25907 Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu Leu Phe His 640 645 650 cgc ggg gtg aac ttc ccc cgc aac atc ttg cat tac tac cgt cac ctc 25955 Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr Arg His Leu 655 660 665 cac agc ccc tac tac tgt ttc caa gaa gag gca gaa acc cag cag cag 26003 His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu Ala Glu Thr Gln Gln Gln 670 675 680 cag aaa acc agc ggc agc tagaaaatcc acagcggcgg cggcaggtgg 26051 Gln Lys Thr Ser Gly Ser 685 actgaggatc gcggcgaacg agccggcgca gacccgggag ctgaggaacc ggatctttcc 26111 caccctctat gccatcttcc agcagagtcg ggggcaggag caggaactga aagtcaagaa 26171 ccgttctctg cgctcgctca cccgcagttg tctgtatcac aagagcgaag accaacttca 26231 gcgcactctc gaggacgccg aggctctctt caacaagtac tgcgcgctca ctcttaaaga 26291 gtagcccgcg cccgcccaca cacggaaaaa ggcgggaatt acgtcaccac ctgcgccctt 26351 cgcccgacca tcatcatgag caaagagatt cccacgcctt acatgtggag ctaccagccc 26411 cagatgggcc tggccgccgg cgccgcccag gactactcca cccgcatgaa ctggctcagt 26471 gccgggcccg cgatgatctc acgggtgaat gacatccgcg cccaccgaaa ccagatactc 26531 ctagaacagt cagcgatcac cgccacgccc cgccatcacc ttaatccgcg taattggccc 26591 gccgccctgg tgtaccagga aattccccag cccacgaccg tactacttcc gcgagacgcc 26651 caggccgaag tccagctgac taactcaggt gtccagctgg ccggcggcgc caccctgtgt 26711 cgtcaccgcc ccgctcaggg tataaagcgg ctggtgatcc gaggcagagg cacacagctc 26771 aacgacgagg tggtgagctc ttcgctgggt ctgcgacctg acggagtctt ccaactcgcc 26831 ggatcgggga gatcttcctt cacgcctcgt caggccgtcc tgactttgga gagttcgtcc 26891 tcacagcccc gctcgggcgg catcggcact ctccagttcg tggaggagtt cactccctcg 26951 gtctacttca accccttctc cggctccccc ggccactacc cggacgagtt catcccgaac 27011 ttcgacgcca tcagcgagtc ggtggacggc tacgattgaa tgtcccatgg tggcgtggct 27071 gacctagctc ggcttcgaca cctggaccac tgccgccgct tccgctgctt cgctcgggat 27131 ctcgccgagt ttgcctactt tgagctgccc gaggagcacc ctcagggccc ggcccacgga 27191 gtgcggatca tcgtcgaagg gggtctcgac tcccacctgc ttcggatctt cagccagcga 27251 ccgatcctgg tcgagcgcga gcaaggacag acccgtctga ccctgtactg catctgcaac 27311 caccccggcc tgc atg aaa gtc ttt gtt gtc tgc tgt gta ctg agt ata 27360 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile 690 695 700 ata aaa gct gag atc agc gac tac tcc gga ctc gat tgt ggt gtt cct 27408 Ile Lys Ala Glu Ile Ser Asp Tyr Ser Gly Leu Asp Cys Gly Val Pro 705 710 715 gct atc aac cag tcc ctg ttc ttc acc ggg aac gag acc gag ctc cag 27456 Ala Ile Asn Gln Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln 720 725 730 ctc cag tgt aag ccc cac aag aag tat ctc acc tgg ctg ttc cag ggc 27504 Leu Gln Cys Lys Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly 735 740 745 tcc ccg atc gcc gtt gtc aac cac tgc gac aac gac gga gtc ctg ctg 27552 Ser Pro Ile Ala Val Val Asn His Cys Asp Asn Asp Gly Val Leu Leu 750 755 760 765 agc ggc cct gcc aac ctt act ttt tcc acc cgc aga agc aag ctc cag 27600 Ser Gly Pro Ala Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln 770 775 780 ctc ttc caa ccc ttc ctc ccc ggg acc tat cag tgc gtc tcg gga ccc 27648 Leu Phe Gln Pro Phe Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro 785 790 795 tgc cat cac acc ttc cac ctg atc ccg aat acc aca gcg ccg ctc ccc 27696 Cys His His Thr Phe His Leu Ile Pro Asn Thr Thr Ala Pro Leu Pro 800 805 810 gct act aac aac caa act acc cac caa cgc cac cgt cgc gac ctt tcc 27744 Ala Thr Asn Asn Gln Thr Thr His Gln Arg His Arg Arg Asp Leu Ser 815 820 825 tct gaa tct aat acc act acc gga ggt gag ctc cga ggt cga cca acc 27792 Ser Glu Ser Asn Thr Thr Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr 830 835 840 845 tct ggg att tac tac ggc ccc tgg gag gtg gtg ggg tta ata gcg cta 27840 Ser Gly Ile Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu 850 855 860 ggc cta gtt gtg ggt ggg ctt ttg gct ctc tgc tac cta tac ctc cct 27888 Gly Leu Val Val Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro 865 870 875 tgc tgt tcg tac tta gtg gtg ctg tgt tgc tgg ttt aag aaa tgg ggc 27936 Cys Cys Ser Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly 880 885 890 aga tca ccc tagtgagctg cggtgtgctg gtggcggtgc tttcgattgt 27985 Arg Ser Pro 895 gggactgggc ggcgcggctg tagtgaagga ggagaaggcc gatccctgct tgcatttcaa 28045 tcccgacaaa tgccagctga gttttcagcc cgatggcaat cggtgcgcgg tgctgatcaa 28105 gtgcggatgg gaatgcgaga acgtgagaat cgagtacaat aacaagactc ggaacaatac 28165 tctcgcgtcc gtgtggcagc ccggggaccc cgagtggtac accgtctctg tccccggtgc 28225 tgacggctcc ccgcgcaccg tgaacaatac tttcattttt gcgcacatgt gcgacacggt 28285 catgtggatg agcaagcagt acgatatgtg gccccccacg aaggagaaca tcgtggtctt 28345 ctccatcgct tacagcctgt gcacggtgct aatcaccgct atcgtgtgcc tgagcattca 28405 catgctcatc gctattcgcc ccagaaataa tgccgaaaaa gaaaaacagc cataacacgt 28465 tttttcacac acctttttca gaccatggcc tctgttaaat ttttgctttt atttgccagt 28525 ctcattactg ttataagtaa tgagaaactc actatttaca ttggcactaa ccacactcta 28585 gaaggaattc caaaatcctc atggtattgc tattttgatc aagatccaga cttaactata 28645 gaactgtgtg gtaacaatgg acaaaataca agcattcatt taattaactt taaatgcgga 28705 gacgatttga aattaattaa tatcactaaa gagtatggag gtatgtatta ctatgttgca 28765 gaaaataaca acatgcagtt ttatgaagtt actgtaacta atcccaccac acctagaaca 28825 acaacaacca ccacaaaaac tacacctgtt accactatgc agctcgctac caataacatt 28885 tttgccatgc gtcaaatggt caacaatagc actcaaccca ccccacccag tgaggaaatt 28945 cccaaatcca tgattggcat tattgttgct gtagtggtgt gcatgttgat catcgccttg 29005 tgcatggtgt actatgcctt ctgctacaga aagcacagac tgaacgacaa gctggaacac 29065 ttactaagtg ttgaatttta attttttaga accatgaaga tcctaggcct tttagttttt 29125 tctatcatta cctctgctct ttgtgaatca gtggataaag atgttactat taccactggt 29185 tctaactata cactgaaagg gccaccctca ggtatgcttt cgtggtattg ctattttgga 29245 aatgacgcag agcaaactga gctttgcaat gcaatgaaag gccaaatgcc aaccacaaaa 29305 attaaacata aatgtgatgg tagtgatcta atactactca atgtcacgaa agcatatggt 29365 ggcagttatt catgccctgc tgccaacact gaggatatga ttttttacaa agtggaagtg 29425 gttgatccca ctactccacc acccaccacc acaactactc acaccacaca cacagaacaa 29485 accacagcag aggaggcagc aaagttagcc ttgcaggtcc aagacagttc atttgttggc 29545 attaccccta cacccgatca gcggtgtccg gggctgctcg tcagcggcat tgtcggtgtg 29605 ctttcgggat tagcagtcat aatcatctgc atgttcattt ttgcttgctg ctatagaagg 29665 ctttaccgac aaaaatcaga cccactgctg aacctctatg tttaattttt tccagagcca 29725 tgaaggcagt tagcactcta attttttgtt ctttgattgg cactgttttt agtgttagct 29785 ttttgaaaca aattaatgtt actgaggggg aaaatgtgac actggtaggc gtagaaggtg 29845 ctcaaaatac cacctggaca aaataccacc tcgatgggtg gaaagatatt tgcaattgga 29905 gtgtcattac ttacacatgt gagggagtta atttgaccat agtcaatgcc agccaaaatc 29965 agaagggttg gattaaaggg caatctgtta gtgttaccag ccaggggtac tatacccagc 30025 atactcttat ttatgacatt gtagttatac cgctgccaac gcctagccca cctagcacca 30085 ctacacaaac aacccacact acacagacaa ccacatacag tacatcaaat caacctacca 30145 ccactacagc agcagaggtt gccagctcgt ctggggtccg agtggcattt ttgttattgg 30205 ccccatctag cagtcccact gctagtacca atgagcagac tactgatttt ttgtccactg 30265 tcgagagcca caccacagct acctcgagtg ccttctctag caccgccaat ctctcctcgc 30325 tttcctctac accaatcagt cccgctacta ctcctagccc cgctcctctt cccactcccc 30385 tgaagcaaac agacggcggc atgcaatggc agatcaccct gctcattgtg atcgggttgg 30445 tcatcctggc cgtgttgctc tactacatct tctgccgccg cattcccaac gcgcaccgca 30505 agccggccta caagcccatc gttatcgggc agccggagcc gcttcaggtg gaagggggtc 30565 taaggaatct tctcttctct tttacagtat ggtgattgaa ctatgattcc tagacaattc 30625 ttgatcacta ttcttatctg cctcctccaa gtctgtgcca ccctcgctct ggtggccaac 30685 gccagtccag actgtattgg gcccttcgcc tcctacgtgc tctttgcctt cgtcacctgc 30745 atctgctgct gtagcatagt ctgcctgctt atcaccttct tccagttcat tgactggatc 30805 tttgtgcgca tcgcctacct gcgccaccac ccccagtacc gcgaccagcg agtggcgcgg 30865 ctgctcaggc tcctctgata agcatgcggg ctctgctact tctcgcgctt ctgctgttag 30925 tgctcccccg tcccgtcgac ccccggtccc ccactcagtc ccccgaggag gtccgcaaat 30985 gcaaattcca agaaccctgg aaattcctca aatgctaccg ccaaaaatca gacatgcatc 31045 ccagctggat catgatcatt gggatcgtga acattctggc ctgcaccctc atctcctttg 31105 tgatttaccc ctactttgac tttggttgga actcgccaga ggcgctctat ctcccgcctg 31165 aacctgacac accaccacag caacctcagg cacacgcact accaccacca cagcctaggc 31225 cacaatacat gcccatatta gactatgagg ccgagccaca gcgacccatg ctccccgcta 31285 ttagttactt caatctaacc ggcggag atg act gac cca ctg gcc aac aac aac 31339 Met Thr Asp Pro Leu Ala Asn Asn Asn 900 905 gtc aac gac ctt ctc ctg gac atg gac ggc cgc gcc tcg gag cag cga 31387 Val Asn Asp Leu Leu Leu Asp Met Asp Gly Arg Ala Ser Glu Gln Arg 910 915 920 ctc gcc caa ctt cgc att cgc cag cag cag gag aga gcc gtc aag gag 31435 Leu Ala Gln Leu Arg Ile Arg Gln Gln Gln Glu Arg Ala Val Lys Glu 925 930 935 ctg cag gac ggc ata gcc atc cac cag tgc aag aaa ggc atc ttc tgc 31483 Leu Gln Asp Gly Ile Ala Ile His Gln Cys Lys Lys Gly Ile Phe Cys 940 945 950 ctg gtg aaa cag gcc aag atc tcc tac gag gtc acc cag acc gac cat 31531 Leu Val Lys Gln Ala Lys Ile Ser Tyr Glu Val Thr Gln Thr Asp His 955 960 965 cgc ctc tcc tac gag ctc ctg cag cag cgc cag aag ttc acc tgc ctg 31579 Arg Leu Ser Tyr Glu Leu Leu Gln Gln Arg Gln Lys Phe Thr Cys Leu 970 975 980 985 gtc gga gtc aac ccc atc gtc atc acc cag cag tcg gga gat acc aag 31627 Val Gly Val Asn Pro Ile Val Ile Thr Gln Gln Ser Gly Asp Thr Lys 990 995 1000 ggg tgc atc cac tgc tcc tgc gac tcc ccc gac tgc gtc cac act 31672 Gly Cys Ile His Cys Ser Cys Asp Ser Pro Asp Cys Val His Thr 1005 1010 1015 ctg atc aag acc ctc tgc ggc ctc cgc gac ctc ctc ccc atg aac 31717 Leu Ile Lys Thr Leu Cys Gly Leu Arg Asp Leu Leu Pro Met Asn 1020 1025 1030 taatcacccc cttatccagt gaa 31740 <210> 21 <211> 505 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 21 Met Glu Ser Arg Asn Pro Phe Gln Gln Gly Leu Pro Ser Gly Leu Leu 1 5 10 15 Ser Ser Ser Phe Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn 20 25 30 Leu Arg Leu Leu Ala Ser Thr Ala Gly Arg His Ala Glu Asp Pro Glu 35 40 45 Ser Pro Val Thr Pro Gly Thr Pro Thr Pro Pro Ala Ala Ala Ala Gly 50 55 60 Ala Ala Ala Arg Gly Gly Gly Gly Gly Pro Arg Arg Glu Pro Glu Ser 65 70 75 80 Arg Ser Gly Pro Ser Gly Gly Gly Gly Gly Gly Val Ala Asp Leu Phe 85 90 95 Pro Glu Leu Arg Arg Val Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg 100 105 110 Gly Ile Lys Arg Glu Arg His Glu Glu Thr Ser His Arg Thr Glu Leu 115 120 125 Thr Val Ser Leu Met Ser Arg Arg Arg Pro Glu Ser Val Trp Trp His 130 135 140 Glu Val Gln Ser Gln Gly Ile Asp Glu Val Ser Val Met His Glu Lys 145 150 155 160 Tyr Ser Leu Glu Gln Val Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp 165 170 175 Trp Glu Val Ala Ile Arg Asn Tyr Ala Lys Leu Ala Leu Lys Pro Asp 180 185 190 Lys Lys Tyr Lys Ile Thr Lys Leu Ile Asn Ile Arg Asn Ser Cys Tyr 195 200 205 Ile Ser Gly Asn Gly Ala Glu Val Glu Ile Ser Thr Gln Glu Arg Val 210 215 220 Ala Phe Arg Cys Cys Met Met Asn Met Tyr Pro Gly Val Val Gly Met 225 230 235 240 Glu Gly Val Thr Phe Met Asn Ala Arg Phe Arg Gly Asp Gly Tyr Asn 245 250 255 Gly Val Val Phe Met Ala Asn Thr Lys Leu Thr Val His Gly Cys Ser 260 265 270 Phe Phe Gly Phe Asn Asn Met Cys Ile Glu Ala Trp Gly Ser Val Ser 275 280 285 Val Arg Gly Cys Ser Phe Ser Ala Asn Trp Met Gly Val Val Gly Arg 290 295 300 Thr Lys Ser Lys Val Ser Val Lys Lys Cys Leu Phe Glu Arg Cys His 305 310 315 320 Met Gly Val Met Ser Glu Gly Glu Ala Lys Val Lys His Cys Ala Ser 325 330 335 Thr Glu Thr Gly Cys Phe Val Leu Ile Lys Gly Asn Ala Gln Val Lys 340 345 350 His Asn Met Ile Cys Gly Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu 355 360 365 Thr Cys Ala Gly Gly Asn Ser His Met Leu Ala Thr Val His Val Ala 370 375 380 Ser His Pro Arg Lys Thr Trp Pro Glu Phe Glu His Asn Val Met Thr 385 390 395 400 Arg Cys Asn Val His Leu Gly Ser Arg Arg Gly Met Phe Met Pro Tyr 405 410 415 Gln Cys Asn Met Gln Phe Val Lys Val Leu Leu Glu Pro Asp Ala Met 420 425 430 Ser Arg Val Ser Leu Thr Gly Val Phe Asp Met Asn Val Glu Met Trp 435 440 445 Lys Ile Leu Arg Tyr Asp Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu 450 455 460 Cys Gly Gly Lys His Ala Arg Leu Gln Pro Val Cys Val Glu Val Thr 465 470 475 480 Glu Asp Leu Arg Pro Asp His Leu Val Leu Ser Cys Asn Gly Thr Glu 485 490 495 Phe Gly Ser Ser Gly Glu Glu Ser Asp 500 505 <210> 22 <211> 184 <212> PRT <213> Unknown <220> <221> misc_feature <222> (84)..(84) <223> The 'Xaa' at location 84 stands for Arg, or Gln. <220> <223> Synthetic Construct <400> 22 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Pro Glu 1 5 10 15 Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Met Glu Asp 20 25 30 Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser Leu Glu 35 40 45 Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala Ala Ala Ala Arg Pro 50 55 60 Ser Ser Ser Ala Glu Glu Glu Lys Ala Ser Ser Thr Asp Thr Ile Ser 65 70 75 80 Ala Pro Gly Xaa Gly Arg Gly Gly Arg Ala His Ser Arg Trp Asp Glu 85 90 95 Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys Glu Arg 100 105 110 Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser Cys 115 120 125 Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu Leu 130 135 140 Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr Arg 145 150 155 160 His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu Ala Glu Thr Gln 165 170 175 Gln Gln Gln Lys Thr Ser Gly Ser 180 <210> 23 <211> 207 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 23 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Asp Cys Gly Val Pro Ala Ile Asn Gln 20 25 30 Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys 35 40 45 Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala 50 55 60 Val Val Asn His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala 65 70 75 80 Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro 85 90 95 Phe Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro Cys His His Thr 100 105 110 Phe His Leu Ile Pro Asn Thr Thr Ala Pro Leu Pro Ala Thr Asn Asn 115 120 125 Gln Thr Thr His Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser Asn 130 135 140 Thr Thr Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile Tyr 145 150 155 160 Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val Val 165 170 175 Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser Tyr 180 185 190 Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 195 200 205 <210> 24 <211> 135 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 24 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu Leu Leu Asp 1 5 10 15 Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg 20 25 30 Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Gly Ile Ala Ile 35 40 45 His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile 50 55 60 Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser Tyr Glu Leu Leu 65 70 75 80 Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val 85 90 95 Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys 100 105 110 Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu 115 120 125 Arg Asp Leu Leu Pro Met Asn 130 135 <210> 25 <211> 36603 <212> DNA <213> Unknown <220> <223> Simian adenovirus A1320 <220> <221> CDS <222> (1599)..(2174) <223> E1b\19K <220> <221> misc_feature <222> (3989)..(5610) <223> IVa2 complement (3989..5319,5599..5610) <220> <221> misc_feature <222> (5599)..(13864) <223> pol complement (5599..8661,13856..13864) <220> <221> misc_feature <222> (6489)..(6489) <223> is c or g <220> <221> misc_feature <222> (8469)..(13864) <223> pTP complement (8469..10406,13856..13864) <220> <221> CDS <222> (10862)..(12034) <223> 52K <220> <221> CDS <222> (12061)..(13821) <223> pIIIa <220> <221> CDS <222> (13904)..(15529) <223> penton <220> <221> CDS <222> (15536)..(16117) <223> pVII <220> <221> CDS <222> (16165)..(17208) <223> V <220> <221> CDS <222> (17236)..(17466) <223> pX <220> <221> CDS <222> (17539)..(18270) <223> pVI <220> <221> CDS <222> (18377)..(21205) <223> hexon <220> <221> CDS <222> (21227)..(21850) <223> protease <220> <221> misc_feature <222> (21935)..(23470) <223> DBP complement (21935..23470) <220> <221> CDS <222> (23499)..(25892) <223> 100K <220> <221> CDS <222> (26518)..(27198) <223> pVIII <220> <221> CDS <222> (27202)..(27519) <223> E3\12.5K <220> <221> CDS <222> (28081)..(28608) <223> E3\gp19K <220> <221> CDS <222> (28641)..(29240) <223> E3\CR1-beta <220> <221> CDS <222> (29257)..(29868) <223> E3\CR1-gamma <220> <221> CDS <222> (29886)..(30761) <223> E3\CR1-delta <220> <221> CDS <222> (31053)..(31481) <223> E3\RID-beta <220> <221> CDS <222> (32178)..(33512) <223> fiber <220> <221> misc_feature <222> (33605)..(34938) <223> E4\orf6/7 complement (33605..33855,34588..34938) <220> <221> misc_feature <222> (33856)..(34758) <223> E4\orf6 complement (33856..34758) <220> <221> misc_feature <222> (34667)..(35029) <223> E4\orf4 complement (34667..35029) <220> <221> misc_feature <222> (34919)..(34938) <223> end of E4\orf6/7 <400> 25 catcatcaat aatatacctc aaactttttg tgcgcgttaa tatgcaaatg aggcgtttga 60 atttggggat gcggggcggt gattggctgt gggaaaggcg accgttaggg gcggggcggg 120 tgacgttttg atgacgtgtt tgtgaggcgg agccggtttg caagttctcg tgggaaaagt 180 gacgtcaaac gaggtgtggt ttgaacacgg aaatactcaa ttttcccgcg ctctctgaca 240 ggaaatgagg tgtttctggg cggatgcaag tgaaaacggg ccattttcgc gcgaaaactg 300 aatgaggaag tgaaaatctg agtaatttcg cgtttatggc agggaggagt atttgccgag 360 ggccgagtag actttgaccg attacgtggg ggtttcgatt accgtgtttt tcacctaaat 420 ttccgcgtac ggtgtcaaag tccggtgttt ttacgtaggt gtcagctgat cgccagggta 480 tttaaacctg cgctctccag tcaagaggcc actcttgagt gccagcgaga agagttttct 540 cctccgcgcc gcgagtcaga tctacacttt gaaagatgag gcacctgaga gacctgcccg 600 gtaatgtttt cctggctact gggaacgaga ttctggaact ggtggtggac gccatgatgg 660 gtgacgaccc tcctgagccc cctaccccat ttgaggcgcc ttcgctgtac gatttgtatg 720 atctggaggt ggatgtgccc gagaacgacc ccaacgagga ggcggtgaat gatttgttta 780 gcgatgccgc gctgctggcc gccgagcagg ctaatacgga ctctggctca gacagcgatt 840 cctctctcca taccacgaga cccggcagag gtgagaaaaa gatccccgag cttaaagggg 900 aagagctcga cctgcgctgc tatgaggaat gcttgcctcc gagcgatgat gaggaggacg 960 aggaggcgat tcgagctgca gcgagcgagg gagtgaaagc tgcgggcgag agctttagcc 1020 tggactgtcc tactctgccc ggacacggct gtaagtcttg tgaatttcat cgcatgaata 1080 ctggagataa gaatgtgatg tgtgccctgt gctatatgag agcttacaac cattgtgttt 1140 acagtaagtg tgattaactt tagctgggaa ggcagagggt gactgggtgc tgactggttt 1200 atttatgtat gtattcttta tgtgtaggtc ccgtctctga cgtagatgag acccccactt 1260 cagagtgcat ttcatcaccc ccagaaattg gcgaggaacc gcccgaagat attattcata 1320 gaccagttgc agtgagagtc accgggcgga gagcagctgt ggagagtttg gatgacttgc 1380 tacagggtgg ggatgaacct ttggacttgt gtacccggaa acgccccagg cactaagtgc 1440 cacacatgtg tgtttactta aggtgatgtc agtatttata gggtgtggag tgcaataaaa 1500 tccgtgttga ctttaagtgc gtggtttatg actcaggggt ggggactgtg ggtatataag 1560 caggtgcaga cctgtgtggt cagttcagag caggactc atg gag atc tgg acg gtc 1616 Met Glu Ile Trp Thr Val 1 5 ttg gaa gac ttt cac cag act aga cag ctg cta gag aac tca tcg gag 1664 Leu Glu Asp Phe His Gln Thr Arg Gln Leu Leu Glu Asn Ser Ser Glu 10 15 20 gga gtc tct tac ctg tgg aga ttc tgc ttc ggt ggg cct cta gct aag 1712 Gly Val Ser Tyr Leu Trp Arg Phe Cys Phe Gly Gly Pro Leu Ala Lys 25 30 35 cta gtc tat agg gcc aaa cag gat tat aag gat caa ttt gag gat att 1760 Leu Val Tyr Arg Ala Lys Gln Asp Tyr Lys Asp Gln Phe Glu Asp Ile 40 45 50 ttg aga gag tgt cct gat att ttt gac tct ctc aac ttg ggc cat cag 1808 Leu Arg Glu Cys Pro Asp Ile Phe Asp Ser Leu Asn Leu Gly His Gln 55 60 65 70 tct cac ttt aac cag agt att ctg aga gcc ctt gac ttt tct act cct 1856 Ser His Phe Asn Gln Ser Ile Leu Arg Ala Leu Asp Phe Ser Thr Pro 75 80 85 ggc aga act acc gcc gcg gta gcc ttt ttt gcc ttt atc ctt gac aaa 1904 Gly Arg Thr Thr Ala Ala Val Ala Phe Phe Ala Phe Ile Leu Asp Lys 90 95 100 tgg agt caa gaa acc cat ttc agc agg gat tac cgt ctg gac tgc tta 1952 Trp Ser Gln Glu Thr His Phe Ser Arg Asp Tyr Arg Leu Asp Cys Leu 105 110 115 gca gta gct ttg tgg aga aca tgg agg tgc cag cgc ctg aat gca atc 2000 Ala Val Ala Leu Trp Arg Thr Trp Arg Cys Gln Arg Leu Asn Ala Ile 120 125 130 tcc ggc tac ttg cca gta cag ccg gta gac acg ctg agg atc ctg agt 2048 Ser Gly Tyr Leu Pro Val Gln Pro Val Asp Thr Leu Arg Ile Leu Ser 135 140 145 150 ctc cag tca ccc cag gaa cac caa cgc cgc cag cag ccg cag cag gag 2096 Leu Gln Ser Pro Gln Glu His Gln Arg Arg Gln Gln Pro Gln Gln Glu 155 160 165 cag cag caa gag gag gag gag gac cga gaa gag aac ccg aga gcc ggt 2144 Gln Gln Gln Glu Glu Glu Glu Asp Arg Glu Glu Asn Pro Arg Ala Gly 170 175 180 ctg gac cct ccg gtg gcg gag gag gag gag tagctgactt gtttcccgag 2194 Leu Asp Pro Pro Val Ala Glu Glu Glu Glu 185 190 ctgcgccggg tgctgactag gtcttccagt ggacgggaga gggggattaa gcgggagagg 2254 catgaggaga ctagtcacag aactgaactg actgtcagtc tgatgagccg caggcgccca 2314 gaatcggtgt ggtggcatga ggttcagtcg caggggatag atgaggtctc ggtaatgcat 2374 gagaaatatt ccctagaaca agtcaagact tgttggttgg agcccgagga tgattgggag 2434 gtagccatca ggaattatgc caagttggct ctgaagccag acaagaagta caagattacc 2494 aagttgatta atatcagaaa ttcctgctac atttcgggga atggggccga ggtggagatc 2554 agtacccagg agagggtggc cttcagatgc tgcatgatga atatgtaccc gggggtggtg 2614 ggcatggagg gagttacctt tatgaacgcg aggtttaggg gtgatgggta taatggggtg 2674 gtctttatgg ccaacaccaa gctgacagtg cacggatgct ccttctttgg cttcaataac 2734 atgtgcatcg aggcctgggg cagtgtttca gtgaggggat gcagcttttc agccaactgg 2794 atgggggtcg tgggcagaac caagagcaag gtgtcagtga agaaatgcct gttcgagagg 2854 tgccacctgg gggtgatgag cgagggcgaa gccaaagtta aacactgcgc ctctaccgag 2914 acgggctgct ttgtgctgat caagggcaat gcccaagtca agcataacat gatctgtggg 2974 gcctcggatg agcgcggcta ccagatgctg acctgcgccg gtgggaacag ccatatgctg 3034 gccaccgtgc atgtggcctc gcacccccgc aagacatggc ccgagttcga gcacaacgtc 3094 atgacccgct gcaatgtgca cctgggctcc cgccgaggca tgttcatgcc ataccagtgc 3154 aacatgcaat ttgtgaaggt gctgctggag cccgatgcca tgtccagagt gagcctgacg 3214 ggggtgtttg acatgaatgt ggagctgtgg aaaattctga gatatgatga atccaagacc 3274 aggtgccggg cctgcgaatg cggaggcaag cacgccaggc ttcagcccgt gtgtgtggag 3334 gtgacggagg acctgcgacc cgatcatttg gtgttgtcct gcaacgggac ggagttcggc 3394 tccagcgggg aagaatctga ctagagtgag tagtgtttgg gggtgggtgg gagcctgcat 3454 gatgggcaga atgactaaaa tctgtgtttt tctgcgcagc agcatgagcg gaagcgcctc 3514 ctttgaggga ggggtattca gcccttatct gacggggcgt ctcccctcct gggctggagt 3574 gcgtcagaat gtgatgggat ccacggtgga cggccggccc gtgcagcccg cgaactcttc 3634 aaccctgacc tacgcgaccc tgagctcctc gtccgtggac gcagctgccg ccgcagctgc 3694 tgcttccgcc gccagcgccg tgcgcggaat ggccctgggt gccggctact acagctctct 3754 ggtggccaac tcgagttccg ccaataatcc cgccagcctg aacgaggaga agctgctgct 3814 gctgatggcc cagctcgagg ccctgaccca gcgcctgggc gagctgaccc agcaggtggc 3874 tcagctgcag gcggagacgc gggccgcggt tgccacggtg aaaaccaaat aaaaaatgaa 3934 tcaataaata aacggaaacg gttgttgatt ttaacacaga gtcttgaatc tttatttgat 3994 ttttcgcgcg cggtaggccc tggaccaccg gtctcgatca ttgagcaccc ggtggatctt 4054 ttccaggacc cggtagaggt gggcttggat gttgaggtac atgggcatga gcccgtcccg 4114 ggggtggagg tagctccact gcagggcctc gtgctcgggg gtggtgttgt aaatcaccca 4174 gtcatagcag gggcgcaggg cgtggtgctg cacgatgtcc ttgaggagga gactgatggc 4234 cacgggcagt cccttggtgt aggtgttgac gaacctgttg agctgggagg gatgcatgcg 4294 gggggagatg agatgcatct tggcctggat cttgagattg gcgatgttcc cacccagatc 4354 ccgccggggg ttcatgttgt gcaggaccac cagcacggtg tatccggtgc acttggggaa 4414 tttgtcatgc aacttggaag ggaaggcgtg aaagaatttg gagacgccct tgtgaccgcc 4474 caggttttcc atgcactcat ccatgatgat ggcgatgggc ccgtgggcgg cggcctgggc 4534 aaagacgttt cgggggtcgg acacatcgta gttgtggtcc tgggtgagct cgtcataggc 4594 cattttaatg aatttggggc ggagggtgcc cgactggggg acaaaggtgc cctcgatccc 4654 gggggcgtag ttgccctcgc agatctgcat ctcccaggcc ttgagctcgg agggggggat 4714 catgtccacc tgcggggcga tgaaaaaaac ggtttccggg gcgggggaga tgagctgggc 4774 cgaaagcagg ttccggagca gctgggactt gccgcagccg gtggggccgt agatgacccc 4834 gatgaccggc tgcaggtggt agttgaggga gagacagctg ccgtcctcgc ggaggagggg 4894 ggccacctcg ttcatcatct cgcgcacatg catgttctcg cgcacgagtt ccgccaggag 4954 gcgctcgccc cccagcgaga ggagctcttg cagcgaggcg aagtttttca gcggcttgag 5014 tccgtcggcc atgggcattt tggagagggt ctgttgcaag agttccagac ggtcccagag 5074 ctcggtgatg tgctctaggg catctcgatc cagcagacct cctcgtttcg cgggttgggg 5134 cggctgcggg agtagggcac caggcgatgg gcgtccagcg aggccagggt ccggtccttc 5194 cagggtcgca gggtccgcgt cagcgtggtc tccgtcacgg tgaaggggtg cgcgccgggc 5254 tgggcgcttg cgagggtgcg cttcaggctc atccggctgg tcgagaaccg ctcccggtcg 5314 gtgccctgcg cgtcggccag gtagcaattg agcatgagtt cgtagttgag cgcctcggcc 5374 gcgtggccct tggcgcggag cttacctttg gaagtgtgtc cgcagacggg acagaggagg 5434 gacttgaggg cgtagagctt gggggcgagg aagacggact cgggggcgta ggcgtccgcg 5494 ccgcagctgg cgcagacggt ctcgcactcc acgagccagg tgaggtcggg gcggtcgggg 5554 tcaaaaacga ggtttcctcc gtgctttttg atgcgtttct tacctctggt ctccatgagc 5614 tcgtgtcccc gctgggtgac aaagaggctg tccgtgtccc cgtagaccga ctttatgggc 5674 cggtcctcga gcggggtgcc gcggtcctcg tcgtagagga accccgccca ctccgagacg 5734 aaggcccggg tccaggccag cacgaaggag gccacgtggg aggggtagcg gtcgttgtcc 5794 accagcgggt ccaccttctc cagggtatgc aagcacatgt ccccctcgtc cacatccagg 5854 aaggtgattg gcttgtaagt gtaggccacg tgaccggggg tcccggccgg gggggtataa 5914 aagggggcgg gcccctgctc gtcctcactg tcttccggat cgctgtccag gagcgccagc 5974 tgttggggta ggtattccct ctcgaaggcg ggcatgacct cggcactcag gttgtcagtt 6034 tctagaaacg aggaggattt gatattgacg gtgccgttgg agacgccttt catgagcccc 6094 tcgtccatct ggtcagaaaa gacgatcttt ttgttgtcga gcttggtggc gaaggagccg 6154 tagagggcat tggagaggag cttggcgatg gagcgcatgg tctggttctt ttccttgtcg 6214 gcgcgctcct tggcggcgat gttgagctgc acgtactcgc gcgccacgca cttccattcg 6274 gggaagacgg tggtgagctc gtcgggcacg attctgaccc gccagccgcg gttgtgcagg 6334 gtgatgaggt ccacgctggt ggccacctcg ccgcgcaggg gctcgttggt ccagcagagg 6394 cgcccgccct tgcgcgagca gaaggggggc agcgggtcca gcatgagctc gtcggggggg 6454 tcggcgtcca cggtgaagat gccgggcagg agctcggggt cgaagtagct gatgcaggtg 6514 cccagatcgt ccagcgccgc ttgccagtcg cgcacggcca gcgcgcgctc gtaggggctg 6574 aggggcgtgc cccagggcat ggggtgcgtg agcgcggagg cgtacatgcc gcagatgtcg 6634 tagacgtaga ggggctcctc gaggacgccg atgtaggtgg ggtagcagcg ccccccgcgg 6694 atgctggcgc gcacgtagtc gtacagctcg tgcgagggcg cgaggagccc cgcgccgagg 6754 ttggagcgct gcggcttttc ggcgcggtag acgatctggc ggaagatggc gtgggagttg 6814 gaggagatgg tgggcctctg gaagatgttg aagtgggcgt ggggcaggcc gaccgagtcc 6874 ctgatgaagt gggcgtagga gtcctgcagc ttggcgacga gctcggcggt gacgaggacg 6934 tccagggcgc agtagtcgag ggtctcttgg atgatgtcgt acttgagctg gcccttctgc 6994 ttccacagct cgcggttgag aaggaactct tcgcggtcct tccagtactc ttcgaggggg 7054 aacccgtcct gatcggcacg gtaagagccc accatgtaga actggttgac ggccttgtag 7114 gcgcagcagc ccttctccac ggggagggca taagcttgcg cggccttgcg cagggaggtg 7174 tgggtgaggg cgaaggtgtc gcgcaccatg accttgagga actggtgctt gaagtcgagg 7234 tcgtcgcagc cgccctgctc ccagagttgg aagtccgtgc gcttcttgta ggcggggttg 7294 ggcaaagcga aagtaacatc gttgaagagg atcttgcccg cgcggggcat gaagttgcga 7354 gtgatgcgga aaggctgggg cacctcggcc cggttgttga tgacctgggc ggcgaggacg 7414 atctcgtcga agccgttgat gttgtgcccg acgatgtaga gttccacgaa tcgcgggcgg 7474 cccttgacgt ggggcagctt cttgagctcg tcgtaggtga gctcggcggg gtcgctgagt 7534 ccgtgctgct caagggccca gtcggcgacg tgggggttgg cgctgaggaa ggaagtccag 7594 agatccacgg ccagggcggt ttgcaagcgg tcccggtact gacggaactg ctggcccacg 7654 gccatttttt cgggggtgat gcagtagaag gtgcgggggt cgccgtgcca gcggtcccac 7714 ttgagctgga gggcgaggtc gtgggcgagc tcgacaagcg gcgggtcccc ggagagtttc 7774 atgaccagca tgaaggggac gagctgcttg ccgaaggacc ccatccaggt gtaggtttcc 7834 acatcgtagg tgaggaagag cctttcggtg cgaggatgcg agccgatggg gaagaactgg 7894 atctcctgcc accagttgga ggaatggctg ttgatgtgat ggaagtagaa atgccgacgg 7954 cgcgccgagc actcgtgctt gtgtttatac aagcgtccgc agtgctcgca acgctgcacg 8014 ggatgcacgt gctgcacgag ctgtacctga gttcctttga cgaggaattt cagtgggcag 8074 tggagcgctg gcggctgcat ctggtgctgt actacgtcct ggccatcggc gtggccatcg 8134 tctgcctcga tggtggtcat gctgacgagc ccgcgcggga ggcaggtcca gacctcggct 8194 cggacgggtc ggagagcgag gacgagggcg cgcaggccgg agctgtccag ggtcctgaga 8254 cgctgcggag tcaggtcagt gggcagcggc ggcgcgcggt tgacttgcag gagcttttcc 8314 agggcgcgcg ggaggtccag atggtacttg atctccacgg cgccgttggt ggcgacgtcc 8374 acggcttgca gggtcccgtg cccctggggc gccaccaccg tgccccgttt cttcttgggc 8434 gctggcggcg ttggcgctgg ttccatgtcg gtcagaagcg gcggcgagga cgcgcgccgg 8494 gcggcagggg cggctcgggg cccggaggca ggggcggcag gggcacgtcg gcgccgcgcg 8554 cgggcaggtt ctggtactgc gcccggagaa gactggcgtg agcgacgacg cgacggttga 8614 cgtcctggat ctgacgcctc tgggtgaagg ccacgggacc cgtgagtttg aacctgaaag 8674 agagttcgac agaatcaatc tcggtatcgt tgacggcggc ctgccgcagg atctcttgca 8734 cgtcgcccga gttgtcctgg taggcgatct cggtcatgaa ctgctcgatc tcctcctcct 8794 gaaggtctcc gcggccggcg cgctcgacgg tggccgcgag gtcgttggag atgcgggcca 8854 tgagctgcga gaaggcgttc atgccggcct cgttccagac gcggctgtag accacggctc 8914 cgtcggggtc gcgcgcgcgc atgaccacct gggcaaggtt gagctcgacg tggcgcgtga 8974 agaccgcgta gttgcagagg cgctggtaga ggtagttgag cgtggtggcg atgtgctcgg 9034 tgacgaagaa gtacatgatc cagcggcgga gcggcatctc gctgacgtcg cccagggctt 9094 ccaagcgctc catggcctcg tagaagtcca cggcgaagtt gaaaaactgg gagttgcgcg 9154 ccgagacggt caactcctcc tccagaagac ggatgagctc tgcgatggtg gcgcgcacct 9214 cgcgctcgaa ggccccgggg ggctcctctt cttccatctc ctcctcctct tcctcctcca 9274 ctaacatctc ttctacttcc tcctcaggcg gtggtggcgg gggagggggc ctgcgtcgcc 9334 ggcggcgcac gggcagacgg tcgatgaagc gctcgatggt ctcgccgcgc cggcgtcgca 9394 tggtctcggt gacggcgcgc ccgtcctcgc ggggccgcag cgtgaagacg ccgccgcgca 9454 tctccaggtg gccggggggg tccccgttgg gcagggagag ggcgctgacg atgcatctta 9514 tcaattgccc cgtagggact ccgcgcaagg acctgagcgt ctcgagatcc acgggatctg 9574 aaaaccgttg aacgaaggct tcgagccagt cgcagtcgca aggtaggctg agcacggttt 9634 cttctggcgg gtcatgttgg ttggagggag cggggcgggc gatgctgctg gtgatgaagt 9694 tgaaataggc ggttctgaga cggcggatgg tggcgaggag caccaggtct ttgggcccgg 9754 cttgctggat gcgcagacgg tcggccatgc cccaggcgtg gtcctgacac ctggccaggt 9814 ccttgtagta gtcctgcatg agccgctcca cgggcacctc ctcctcgccc gcgcggccgt 9874 gcatgcgcgt gagcccgaag ccgcgctggg gctggacgag cgccaggtcg gcgacgacgc 9934 gctcggcgag gatggcctgc tggacctggg tgagggtggt ctggaagtcg tcgaagtcga 9994 cgaagcggtg gtaggctccg gtgttgatgg tgtaggagca gttggccatg acggaccagt 10054 tgacggtctg gtggccgggg cgcacgagct cgtggtactt gaggcgcgag taggcgcgcg 10114 tgtcgaagat gtagtcgttg caggtgcgca cgaggtactg gtatccgacg aggaagtgcg 10174 gcggcggctg gcggtagagc ggccatcgct cggtggcggg ggcgccgggc gcgaggtcct 10234 cgagcatgag gcggtggtag ccgtagatgt acctggacat ccaggtgatg ccggcggcgg 10294 tggtggaggc gcgcgggaac tcgcggacgc ggttccagat gttgcgcagc ggcaggaagt 10354 agttcatggt ggccgcggtc tggcccgtga ggcgcgcgca gtcgtggatg ctctagacat 10414 acgggcaaaa acgaaagcgg tcagcggctc gactccgtgg cctggaggct aagcgaacgg 10474 gttgggctgc gcgtgtaccc cggttcgagt ctctgctcga atcaggctgg agccgcagct 10534 aacgtggtac tggcactccc gtctcgaccc aagcctgcta acgaaacctc caggatacgg 10594 aggcgggtcg ttttttggcc ttggtcactg gtcatgaaaa actagtaagc gcggaaagcg 10654 gccgcccgcg atggctcgct gccgtagtct ggagaaagaa tcgccagggt tgcgttgcgg 10714 tgtgccccgg ttcgagactc agcgctcggc gccggccgga ttccgcggct aacgtgggcg 10774 tggctgcccc gtcgtttcca agacccctta gccagccgac ttctccagtt acggagcgag 10834 cccctctttt tcttgtgttt ttgccag atg cat ccc gta ctg cgg cag atg cgc 10888 Met His Pro Val Leu Arg Gln Met Arg 195 200 ccc cac cct cca cca caa ccg ccc cta ccg ccg cag cag cag caa cag 10936 Pro His Pro Pro Pro Gln Pro Pro Leu Pro Pro Gln Gln Gln Gln Gln 205 210 215 ccg gcg ctt ctg ccc ccg ccc cag cag cag cca gcc act acc gcg gcg 10984 Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln Pro Ala Thr Thr Ala Ala 220 225 230 gcc gcc gtg agc gga gcc ggc gtt cag tat gac ctg gcc ttg gaa gag 11032 Ala Ala Val Ser Gly Ala Gly Val Gln Tyr Asp Leu Ala Leu Glu Glu 235 240 245 ggc gag ggg ctg gcg cgg ctg ggg gcg tcg tcg ccg gag cgg cac ccg 11080 Gly Glu Gly Leu Ala Arg Leu Gly Ala Ser Ser Pro Glu Arg His Pro 250 255 260 265 cgc gtg cag atg aaa agg gac gct cgc gag gcc tac gtg ccc aag cag 11128 Arg Val Gln Met Lys Arg Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln 270 275 280 aac ctg ttc aga gac agg agc ggc gag gag ccc gag gag atg cgc gcc 11176 Asn Leu Phe Arg Asp Arg Ser Gly Glu Glu Pro Glu Glu Met Arg Ala 285 290 295 tcc cgc ttc cac gcg ggg cgg gag ctg cgg cgc ggc ctg gac cga aag 11224 Ser Arg Phe His Ala Gly Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys 300 305 310 cgg gtg ctg agg gac gag gat ttc gag gcg gac gag ctg acg ggg atc 11272 Arg Val Leu Arg Asp Glu Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile 315 320 325 agc ccc gcg cgc gcg cac gtg gcc gcg gcc aac ctg gtc acg gcg tac 11320 Ser Pro Ala Arg Ala His Val Ala Ala Ala Asn Leu Val Thr Ala Tyr 330 335 340 345 gag cag acc gtg aag gag gag agc aac ttc caa aaa tcc ttc aac aac 11368 Glu Gln Thr Val Lys Glu Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn 350 355 360 cac gtg cgc acg ctg atc gcg cgc gag gag gtg acc ctg ggc ctg atg 11416 His Val Arg Thr Leu Ile Ala Arg Glu Glu Val Thr Leu Gly Leu Met 365 370 375 cat ctg tgg gac ctg ttg gag gcc atc gtg cag aac ccc acg agc aag 11464 His Leu Trp Asp Leu Leu Glu Ala Ile Val Gln Asn Pro Thr Ser Lys 380 385 390 ccg ctg acg gcg cag ctg ttt ctg gtg gtg cag cac agt cgg gac aac 11512 Pro Leu Thr Ala Gln Leu Phe Leu Val Val Gln His Ser Arg Asp Asn 395 400 405 gag acg ttc agg gag gcg ctg ctg aat atc acc gag ccc gag ggc cgc 11560 Glu Thr Phe Arg Glu Ala Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg 410 415 420 425 tgg ctc ctg gac ctg gtg aac att ctg cag agc atc gtg gtg cag gag 11608 Trp Leu Leu Asp Leu Val Asn Ile Leu Gln Ser Ile Val Val Gln Glu 430 435 440 cgc ggg ctg ccg ctg tcc gag aag ctg gcg gcc atc aac ttc tcg gtg 11656 Arg Gly Leu Pro Leu Ser Glu Lys Leu Ala Ala Ile Asn Phe Ser Val 445 450 455 ctg agc ctg ggc aag tac tac gct agg aag atc tac aag acc ccg tac 11704 Leu Ser Leu Gly Lys Tyr Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr 460 465 470 gtg ccc ata gac aag gag gtg aag atc gac ggg ttt tac atg cgc atg 11752 Val Pro Ile Asp Lys Glu Val Lys Ile Asp Gly Phe Tyr Met Arg Met 475 480 485 acc ctg aaa gtg ctg acc ctg agc gac gat ctg ggg gtg tac cgc aac 11800 Thr Leu Lys Val Leu Thr Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn 490 495 500 505 gac agg atg cac cgc gcg gtg agc gcc agc cgc cgg cgc gag ctg agc 11848 Asp Arg Met His Arg Ala Val Ser Ala Ser Arg Arg Arg Glu Leu Ser 510 515 520 gac cag gag ctg atg cac agc ctg cag cgg gcc ctg acc ggg gcc ggg 11896 Asp Gln Glu Leu Met His Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly 525 530 535 acc gag ggg gag agc tac ttt gac atg ggc gcg gac ctg cgc tgg cag 11944 Thr Glu Gly Glu Ser Tyr Phe Asp Met Gly Ala Asp Leu Arg Trp Gln 540 545 550 ccc agc cgc cgg gct tta gag gca gcc ggc ggc gtg ccc tac gtg gag 11992 Pro Ser Arg Arg Ala Leu Glu Ala Ala Gly Gly Val Pro Tyr Val Glu 555 560 565 gag gtg gac gat gat gag gag gag ggc gag tac ctg gaa gac 12034 Glu Val Asp Asp Asp Glu Glu Glu Gly Glu Tyr Leu Glu Asp 570 575 580 tgatggcgcg accgtatttt tgctag atg cag caa cag cca ccg cct cct gat 12087 Met Gln Gln Gln Pro Pro Pro Pro Asp 585 590 ccc gcg atg cgg gcg gcg ctg cag agc cag ccg tcc ggc att aac tcc 12135 Pro Ala Met Arg Ala Ala Leu Gln Ser Gln Pro Ser Gly Ile Asn Ser 595 600 605 tcg gac gat tgg acc cag gcc atg caa cgc atc atg gcg ctg acg acc 12183 Ser Asp Asp Trp Thr Gln Ala Met Gln Arg Ile Met Ala Leu Thr Thr 610 615 620 cgc aat ccc gaa gcc ttt aga cag cag cct cag gcc aac cgg ctc tcg 12231 Arg Asn Pro Glu Ala Phe Arg Gln Gln Pro Gln Ala Asn Arg Leu Ser 625 630 635 640 gcc atc ctg gag gcc gtg gtg ccc tcg cgc tcg aac ccc acg cac gag 12279 Ala Ile Leu Glu Ala Val Val Pro Ser Arg Ser Asn Pro Thr His Glu 645 650 655 aag gtg ctg gcc atc gtg aac gcg ctg gtg gag aac aag gcc atc cgc 12327 Lys Val Leu Ala Ile Val Asn Ala Leu Val Glu Asn Lys Ala Ile Arg 660 665 670 ggc gac gag gcc ggg ctg gtg tac aac gcg ctg ctg gag cgc gtg gcc 12375 Gly Asp Glu Ala Gly Leu Val Tyr Asn Ala Leu Leu Glu Arg Val Ala 675 680 685 cgc tac aac agc acc aac gtg cag acg aac ctg gac cgc atg gtg acc 12423 Arg Tyr Asn Ser Thr Asn Val Gln Thr Asn Leu Asp Arg Met Val Thr 690 695 700 gac gtg cgc gag gcg gtg tcg cag cgc gag cgg ttc cac cgc gag tcg 12471 Asp Val Arg Glu Ala Val Ser Gln Arg Glu Arg Phe His Arg Glu Ser 705 710 715 720 aac ctg ggc tcc atg gtg gcg ctg aac gcc ttc ctg agc acg cag ccc 12519 Asn Leu Gly Ser Met Val Ala Leu Asn Ala Phe Leu Ser Thr Gln Pro 725 730 735 gcc aac gtg ccc cgg ggc cag gag gac tac acc aac ttt atc agc gcg 12567 Ala Asn Val Pro Arg Gly Gln Glu Asp Tyr Thr Asn Phe Ile Ser Ala 740 745 750 ctg cgg ctg atg gtg gcc gag gtg ccc cag agc gag gtg tac cag tcg 12615 Leu Arg Leu Met Val Ala Glu Val Pro Gln Ser Glu Val Tyr Gln Ser 755 760 765 ggg ccg gac tac ttc ttc cag acc agt cgc cag ggc ttg cag acc gtg 12663 Gly Pro Asp Tyr Phe Phe Gln Thr Ser Arg Gln Gly Leu Gln Thr Val 770 775 780 aac ctg agc cag gct ttc aag aac ttg cag gga ctg tgg ggc gtg cag 12711 Asn Leu Ser Gln Ala Phe Lys Asn Leu Gln Gly Leu Trp Gly Val Gln 785 790 795 800 gcc ccg gtc ggg gac cgc gcg acg gtg tcg agc ctg ctg acg ccg aac 12759 Ala Pro Val Gly Asp Arg Ala Thr Val Ser Ser Leu Leu Thr Pro Asn 805 810 815 tcg cgc ctg ctg ctg ctg ctg gtg gcg ccc ttc acg gac agc ggc agc 12807 Ser Arg Leu Leu Leu Leu Leu Val Ala Pro Phe Thr Asp Ser Gly Ser 820 825 830 gtg agc cgc gac tcg tac ctg ggc tac ctg ctt aac ctg tac cgc gag 12855 Val Ser Arg Asp Ser Tyr Leu Gly Tyr Leu Leu Asn Leu Tyr Arg Glu 835 840 845 gcc atc ggg cag gcg cac gtg gac gag cag acc tac cag gag atc acc 12903 Ala Ile Gly Gln Ala His Val Asp Glu Gln Thr Tyr Gln Glu Ile Thr 850 855 860 cac gtg agc cgc gcg ctg ggc cag gag gac ccg ggc aac ctg gag gcc 12951 His Val Ser Arg Ala Leu Gly Gln Glu Asp Pro Gly Asn Leu Glu Ala 865 870 875 880 acc ctg aac ttc ctg ctg acc aac cgg tcg cag aag atc ccg ccc cag 12999 Thr Leu Asn Phe Leu Leu Thr Asn Arg Ser Gln Lys Ile Pro Pro Gln 885 890 895 tac gcg ctg agc acc gag gag gag cgc atc ctg cgc tac gtg cag cag 13047 Tyr Ala Leu Ser Thr Glu Glu Glu Arg Ile Leu Arg Tyr Val Gln Gln 900 905 910 agc gtg ggg ctg ttc ctg atg cag gag ggg gcc acg ccc agc gcc gcg 13095 Ser Val Gly Leu Phe Leu Met Gln Glu Gly Ala Thr Pro Ser Ala Ala 915 920 925 ctc gac atg acc gcg cgc aac atg gag ccc agc atg tac gcc cgc aac 13143 Leu Asp Met Thr Ala Arg Asn Met Glu Pro Ser Met Tyr Ala Arg Asn 930 935 940 cgc ccg ttc atc aat aag ctg atg gac tac ttg cat cgg gcg gcc gcc 13191 Arg Pro Phe Ile Asn Lys Leu Met Asp Tyr Leu His Arg Ala Ala Ala 945 950 955 960 atg aac tcg gac tac ttt acc aac gcc atc ttg aac ccg cac tgg ctc 13239 Met Asn Ser Asp Tyr Phe Thr Asn Ala Ile Leu Asn Pro His Trp Leu 965 970 975 ccg ccg ccc ggg ttc tac acg ggc gag tac gac atg ccc gac ccc aac 13287 Pro Pro Pro Gly Phe Tyr Thr Gly Glu Tyr Asp Met Pro Asp Pro Asn 980 985 990 gac ggg ttc ctg tgg gac gac gtg gac agc agc gtg ttc tcg ccg cgc 13335 Asp Gly Phe Leu Trp Asp Asp Val Asp Ser Ser Val Phe Ser Pro Arg 995 1000 1005 ccc acc acc acc gtg tgg aag aaa gag ggc ggg gac cgg cgg ccg 13380 Pro Thr Thr Thr Val Trp Lys Lys Glu Gly Gly Asp Arg Arg Pro 1010 1015 1020 tcc tcg gcg ctg tcc ggt cgc gcg ggt gct gcc gcg gcg gtg ccc 13425 Ser Ser Ala Leu Ser Gly Arg Ala Gly Ala Ala Ala Ala Val Pro 1025 1030 1035 gag gcc gcc agc ccc ttc ccg agc ctg ccc ttt tcg ctg aac agc 13470 Glu Ala Ala Ser Pro Phe Pro Ser Leu Pro Phe Ser Leu Asn Ser 1040 1045 1050 gtg cgc agc agc gag ctg ggt cgg ctg acg cgg ccg cgc ctg ctg 13515 Val Arg Ser Ser Glu Leu Gly Arg Leu Thr Arg Pro Arg Leu Leu 1055 1060 1065 ggc gag gag gag tac ctg aac gac tcc ttg ttg agg ccc gag cgc 13560 Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu Arg Pro Glu Arg 1070 1075 1080 gag aaa aac ttc ccc aat aac ggg ata gag agc ctg gtg gac aag 13605 Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu Val Asp Lys 1085 1090 1095 atg agc cgc tgg aag acg tac gcg cac gag cac agg gac gag ccc 13650 Met Ser Arg Trp Lys Thr Tyr Ala His Glu His Arg Asp Glu Pro 1100 1105 1110 cga gct agc agc agc gcc ggc gcc acc cgt aga cgc cag cgg cac 13695 Arg Ala Ser Ser Ser Ala Gly Ala Thr Arg Arg Arg Gln Arg His 1115 1120 1125 gac agg cag cgg gga ctg gtg tgg gac gat gag gat tcc gcc gac 13740 Asp Arg Gln Arg Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp 1130 1135 1140 gac agc agc gtg ttg gac ttg ggt ggg agt ggt ggt ggt aac ccg 13785 Asp Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro 1145 1150 1155 ttc gct cac ttg cgc ccc cgt atc ggg cgc ctg atg taagaatctg 13831 Phe Ala His Leu Arg Pro Arg Ile Gly Arg Leu Met 1160 1165 1170 aaaaaataaa aaaacggtac tcaccaaggc catggcgacc agcgtgcgtt cttctctgtt 13891 gtttgtagta gt atg atg agg cgc gtg tac ccg gag ggt cct cct ccc 13939 Met Met Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro 1175 1180 tcg tac gag agc gtg atg cag cag gcg gtg gcg gcg gcg atg cag 13984 Ser Tyr Glu Ser Val Met Gln Gln Ala Val Ala Ala Ala Met Gln 1185 1190 1195 ccc ccg ctg gag gcg cct tac gtg ccc ccg cgg tac ctg gcg cct 14029 Pro Pro Leu Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro 1200 1205 1210 acg gag ggg cgg aac agc att cgt tac tcg gag ctg gca ccc ttg 14074 Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu 1215 1220 1225 tac gat acc acc cgg ttg tac ctg gtg gac aac aag tcg gcg gac 14119 Tyr Asp Thr Thr Arg Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp 1230 1235 1240 atc gcc tcg ctg aac tac cag aac gac cac agc aac ttc ctg acc 14164 Ile Ala Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr 1245 1250 1255 acc gtg gtg cag aac aac gat ttc acc ccc acg gag gcc agc acc 14209 Thr Val Val Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr 1260 1265 1270 cag acc atc aac ttt gac gag cgc tcg cgg tgg ggc ggc cag ctg 14254 Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu 1275 1280 1285 aaa acc atc atg cac acc aac atg ccc aac gtg aac gag ttc atg 14299 Lys Thr Ile Met His Thr Asn Met Pro Asn Val Asn Glu Phe Met 1290 1295 1300 tac agc aac aag ttc aag gcg cgg gtg atg gtc tcg cgc aag acc 14344 Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser Arg Lys Thr 1305 1310 1315 ccc aac ggg gtg acg gtg gat gag aat tat gat ggt agt cag gac 14389 Pro Asn Gly Val Thr Val Asp Glu Asn Tyr Asp Gly Ser Gln Asp 1320 1325 1330 gag ctg acc tac gag tgg gtg gag ttt gag ctg ccc gag ggc aac 14434 Glu Leu Thr Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn 1335 1340 1345 ttc tcg gtg acc atg acc atc gat ctg atg aac aac gcc atc atc 14479 Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile 1350 1355 1360 gac aac tac ttg gcg gtg gga cgg cag aac ggg gtg ctg gag agc 14524 Asp Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser 1365 1370 1375 gac atc ggc gtg aag ttc gac acg cgc aac ttc cgg ctg ggc tgg 14569 Asp Ile Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp 1380 1385 1390 gac ccc gtg acc gag ctg gtg atg ccg ggc gtg tac acc aac gag 14614 Asp Pro Val Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu 1395 1400 1405 gcc ttc cac ccc gac atc gtc ctg ctg ccc ggc tgc ggc gtg gac 14659 Ala Phe His Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp 1410 1415 1420 ttc acc gag agc cgc ctc agc aac ctg ctg ggc atc cgc aag cgg 14704 Phe Thr Glu Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg 1425 1430 1435 cag ccc ttc cag gag ggc ttc cag atc ctg tac gag gac ctg gag 14749 Gln Pro Phe Gln Glu Gly Phe Gln Ile Leu Tyr Glu Asp Leu Glu 1440 1445 1450 ggg ggc aac atc ccc gcg ctg ctg gac gtc gaa gcc tac gag aaa 14794 Gly Gly Asn Ile Pro Ala Leu Leu Asp Val Glu Ala Tyr Glu Lys 1455 1460 1465 agc aag gag gag gcc gcc gca gcg gcg acc gcg gcc gtg gct acc 14839 Ser Lys Glu Glu Ala Ala Ala Ala Ala Thr Ala Ala Val Ala Thr 1470 1475 1480 gct gcg acc acc gat gca gat gca gct act act acc agg ggc gat 14884 Ala Ala Thr Thr Asp Ala Asp Ala Ala Thr Thr Thr Arg Gly Asp 1485 1490 1495 aca ttc gcc acc cag gcg gag gaa gca gcc gcc cta gcg gcg acc 14929 Thr Phe Ala Thr Gln Ala Glu Glu Ala Ala Ala Leu Ala Ala Thr 1500 1505 1510 gat gat agt gaa agt aag ata gtc atc aag ccg gtg gag aag gac 14974 Asp Asp Ser Glu Ser Lys Ile Val Ile Lys Pro Val Glu Lys Asp 1515 1520 1525 agc aag gac agg agc tac aac gtt cta tcg gat gga aag aac acc 15019 Ser Lys Asp Arg Ser Tyr Asn Val Leu Ser Asp Gly Lys Asn Thr 1530 1535 1540 gcc tac cgc agc tgg tac ctg gcc tac aac tac ggc gac cct gag 15064 Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly Asp Pro Glu 1545 1550 1555 aag ggc gtg cgc tcc tgg acg ctg ctc acc acc tcg gac gtc acc 15109 Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp Val Thr 1560 1565 1570 tgc ggc gtg gag caa gtc tac tgg tcg ctg ccc gac atg atg caa 15154 Cys Gly Val Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met Gln 1575 1580 1585 gac ccg gtc acc ttc cgc tcc acg cgt caa gtt agc aac tac ccg 15199 Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn Tyr Pro 1590 1595 1600 gtg gtg ggc gcc gag ctc ctg ccc gtc tac tcc aag agc ttc ttc 15244 Val Val Gly Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser Phe Phe 1605 1610 1615 aac gag cag gcc gtc tac tcg cag cag ctg cgc gcc ttc acc tcg 15289 Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Ala Phe Thr Ser 1620 1625 1630 ctc acg cac gtc ttc aac cgc ttc ccc gag aac cag atc ctc gtc 15334 Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Val 1635 1640 1645 cgc ccg ccc gcg ccc acc att acc acc gtc agt gaa aac gtt cct 15379 Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro 1650 1655 1660 gct ctc aca gat cac ggg acc ctg ccg ctg cgc agc agt atc cgg 15424 Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg 1665 1670 1675 gga gtc cag cgc gtg acc gtc act gac gcc aga cgc cgc acc tgc 15469 Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys 1680 1685 1690 ccc tac gtc tac aag gcc ctg ggc gta gtc gcg ccg cgc gtc ctc 15514 Pro Tyr Val Tyr Lys Ala Leu Gly Val Val Ala Pro Arg Val Leu 1695 1700 1705 tcg agc cgc acc ttc taaaaa atg tcc att ctc atc tcg ccc agt aat 15562 Ser Ser Arg Thr Phe Met Ser Ile Leu Ile Ser Pro Ser Asn 1710 1715 1720 aac acc ggt tgg ggc ctg cgc gcg ccc agc aag atg tac gga ggc 15607 Asn Thr Gly Trp Gly Leu Arg Ala Pro Ser Lys Met Tyr Gly Gly 1725 1730 1735 gct cgc caa cgc tcc acg caa cac ccc gtg cgc gtg cgc ggg cac 15652 Ala Arg Gln Arg Ser Thr Gln His Pro Val Arg Val Arg Gly His 1740 1745 1750 ttc cgc gct ccc tgg ggc gcc ctc aag ggc cgc gtg cgc tcg cgc 15697 Phe Arg Ala Pro Trp Gly Ala Leu Lys Gly Arg Val Arg Ser Arg 1755 1760 1765 acc acc gtc gac gac gtg atc gac cag gtg gtg gcc gac gcg cgc 15742 Thr Thr Val Asp Asp Val Ile Asp Gln Val Val Ala Asp Ala Arg 1770 1775 1780 aac tac acg ccc gcc gcc gcg ccc gcc tcc acc gtg gac gcc gtc 15787 Asn Tyr Thr Pro Ala Ala Ala Pro Ala Ser Thr Val Asp Ala Val 1785 1790 1795 atc gac agc gtg gtg gcc gac gcg cgc cgg tac gcc cgc gcc aag 15832 Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala Arg Ala Lys 1800 1805 1810 agc cgg cgg cgg cgc atc gcc cgg cgg cac cgg agc acc ccc gcc 15877 Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr Pro Ala 1815 1820 1825 atg cgc gcg gcg cga gcc ttg ctg cgc agg gcc agg cgc acg gga 15922 Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr Gly 1830 1835 1840 cgc agg gcc atg ctc agg gcg gcc aga cgc gcg gcc tcc ggc agc 15967 Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ser 1845 1850 1855 agc agc gcc ggc agg acc cgc aga cgc gcg gcc acg gcg gcg gcg 16012 Ser Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala 1860 1865 1870 gcg gcc atc gcc agc atg tcc cgc ccg cgg cgc ggc aac gtg tac 16057 Ala Ala Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr 1875 1880 1885 tgg gtg cgc gac gcc gcc acc ggt gtg cgc gtg ccc gtg cgc acc 16102 Trp Val Arg Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr 1890 1895 1900 cgc ccc cct cgc act tgaagatgct gacttcgcga tgttgatgtg tcccagcggc 16157 Arg Pro Pro Arg Thr 1905 gaggagg atg tcc aag cgc aaa ttc aag gaa gag atg ctc cag gtc 16203 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val 1910 1915 atc gcg cct gag atc tac ggc ccc gcg gcg gcg gtg aag gag gaa 16248 Ile Ala Pro Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys Glu Glu 1920 1925 1930 aga aag ccc cgc aaa ctg aag cgg gtc aaa aag gac aaa aag gag 16293 Arg Lys Pro Arg Lys Leu Lys Arg Val Lys Lys Asp Lys Lys Glu 1935 1940 1945 gag gaa gat gac gga ctg gtg gag ttt gtg cgc gag ttc gcc ccc 16338 Glu Glu Asp Asp Gly Leu Val Glu Phe Val Arg Glu Phe Ala Pro 1950 1955 1960 cgg cgg cgc gtg cag tgg cgc ggg cgg aaa gtg aaa ccg gtg ctg 16383 Arg Arg Arg Val Gln Trp Arg Gly Arg Lys Val Lys Pro Val Leu 1965 1970 1975 cgg ccc ggc acc acg gtg gtc ttc acg ccc ggc gag cgt tcc ggc 16428 Arg Pro Gly Thr Thr Val Val Phe Thr Pro Gly Glu Arg Ser Gly 1980 1985 1990 tcc gcc tcc aag cgc tcc tac gac gag gtg tac ggg gac gag gac 16473 Ser Ala Ser Lys Arg Ser Tyr Asp Glu Val Tyr Gly Asp Glu Asp 1995 2000 2005 atc ctc gag cag gcg gcc gag cgt ctg ggc gag ttt gct tac ggc 16518 Ile Leu Glu Gln Ala Ala Glu Arg Leu Gly Glu Phe Ala Tyr Gly 2010 2015 2020 aag cgc agc cgc ccc gcg ccc ttg aaa gag gag gcg gtg tcc atc 16563 Lys Arg Ser Arg Pro Ala Pro Leu Lys Glu Glu Ala Val Ser Ile 2025 2030 2035 ccg ctg gac cac ggc aac ccc acg ccg agc ctg aag ccg gtg acc 16608 Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu Lys Pro Val Thr 2040 2045 2050 ctg cag cag gtg ctg ccg agc gcg gcg ccg cgc cgg ggc ttc aag 16653 Leu Gln Gln Val Leu Pro Ser Ala Ala Pro Arg Arg Gly Phe Lys 2055 2060 2065 cgc gag ggc ggc gag gat ctg tac ccg acc atg cag ctg atg gtg 16698 Arg Glu Gly Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met Val 2070 2075 2080 ccc aag cgc cag aag ctg gag gac gtg ctg gag cac atg aag gtg 16743 Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu His Met Lys Val 2085 2090 2095 gac ccc gag gtg cag ccc gag gtc aag gtg cgg ccc atc aag cag 16788 Asp Pro Glu Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln 2100 2105 2110 gtg gcc ccg ggc ctg ggc gtg cag acc gtg gac atc aag atc ccc 16833 Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro 2115 2120 2125 acg gag ccc atg gaa acg cag acc gag ccc gtg aag ccc agc acc 16878 Thr Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr 2130 2135 2140 agc acc atg gag gtg cag acg gat ccc tgg atg ccg gcg ccg gct 16923 Ser Thr Met Glu Val Gln Thr Asp Pro Trp Met Pro Ala Pro Ala 2145 2150 2155 tcc acc acc acc acc acc cgc cga aga cgc aag tac ggc gcg gcc 16968 Ser Thr Thr Thr Thr Thr Arg Arg Arg Arg Lys Tyr Gly Ala Ala 2160 2165 2170 agc ctg ctg atg ccc aac tac gcg ctg cat cct tcc atc atc ccc 17013 Ser Leu Leu Met Pro Asn Tyr Ala Leu His Pro Ser Ile Ile Pro 2175 2180 2185 acg ccg ggc tac cgc ggc acg cgc ttc tac cgc ggc tac agc agc 17058 Thr Pro Gly Tyr Arg Gly Thr Arg Phe Tyr Arg Gly Tyr Ser Ser 2190 2195 2200 cgc cgc aag acc acc acc cgc cgc cgc cgt cgc cgc acc cgc cgc 17103 Arg Arg Lys Thr Thr Thr Arg Arg Arg Arg Arg Arg Thr Arg Arg 2205 2210 2215 agc acc acc gcg act tcc gcc gcc gcc ttg gtg cgg aga gtg tac 17148 Ser Thr Thr Ala Thr Ser Ala Ala Ala Leu Val Arg Arg Val Tyr 2220 2225 2230 cgc agc ggg cgt gag cct ctg acc ctg ccg cgc gcg cgc tac cac 17193 Arg Ser Gly Arg Glu Pro Leu Thr Leu Pro Arg Ala Arg Tyr His 2235 2240 2245 ccg agc atc gcc att taactctgcc gtcgcctcct tgcagat atg gcc ctc 17244 Pro Ser Ile Ala Ile Met Ala Leu 2250 2255 aca tgc cgc ctc cgc gtc ccc att acg ggc tac cga gga aga aag 17289 Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly Arg Lys 2260 2265 2270 ccg cgc cgt aga agg ctg acg ggg aac ggg ctg cgt cgc cat cac 17334 Pro Arg Arg Arg Arg Leu Thr Gly Asn Gly Leu Arg Arg His His 2275 2280 2285 cac cgg cgg cgg cgc gcc atc agc aag cgg ttg ggg gga ggc ttc 17379 His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 2290 2295 2300 ctg ccc gcg ctg atc ccc atc atc gcc gcg gcg atc ggg gcg atc 17424 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile 2305 2310 2315 ccc ggc ata gct tcc gtg gcg gtg cag gcc tct cag cgc cac 17466 Pro Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 2320 2325 2330 tgagacacag cttggaaaat ttgtaataaa aaaatggact gacgctcctg gtcctgtgat 17526 gtgtgttttt ag atg gaa gac atc aat ttt tcg tcc ctg gca ccg cga 17574 Met Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg 2335 2340 cac ggc acg cgg ccg ttt atg ggc acc tgg agc gac atc ggc aac 17619 His Gly Thr Arg Pro Phe Met Gly Thr Trp Ser Asp Ile Gly Asn 2345 2350 2355 agc caa ctg aac ggg ggc gcc ttc aat tgg agc agt ctc tgg agc 17664 Ser Gln Leu Asn Gly Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser 2360 2365 2370 ggg ctt aag aat ttc ggg tcc acg ctc aaa acc tat ggc agc aag 17709 Gly Leu Lys Asn Phe Gly Ser Thr Leu Lys Thr Tyr Gly Ser Lys 2375 2380 2385 gcg tgg aac agc acc aca ggg cag gcg ctg agg gat aag ctg aaa 17754 Ala Trp Asn Ser Thr Thr Gly Gln Ala Leu Arg Asp Lys Leu Lys 2390 2395 2400 gag cag aac ttc cag cag aag gtg gtc gat ggg ctc gct tcg ggc 17799 Glu Gln Asn Phe Gln Gln Lys Val Val Asp Gly Leu Ala Ser Gly 2405 2410 2415 atc aac ggg gtg gtg gac ctg gcc aac cag gcc gtg cag cgg cag 17844 Ile Asn Gly Val Val Asp Leu Ala Asn Gln Ala Val Gln Arg Gln 2420 2425 2430 atc aac agc cgc ctg gac ccg gtg ccg ccc gcc ggc tcc gtg gag 17889 Ile Asn Ser Arg Leu Asp Pro Val Pro Pro Ala Gly Ser Val Glu 2435 2440 2445 atg ccg cag gtg gag gag gag ctg cct ccc ctg gac aag cgg ggc 17934 Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu Asp Lys Arg Gly 2450 2455 2460 gag aag cga ccc cgc ccc gac gcg gag gag acg ctg ctg acg cac 17979 Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu Leu Thr His 2465 2470 2475 acg gac gag ccg ccc ccg tac gag gag gcg gtg aaa ctg ggt ctg 18024 Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu Gly Leu 2480 2485 2490 ccc acc acg cgg ccc att gcg ccc cta gcc acc ggg gtg ctg aaa 18069 Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu Lys 2495 2500 2505 ccc gag agt aat aag ccc gcg acc ctg gac ttg cct cct ccc cag 18114 Pro Glu Ser Asn Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Gln 2510 2515 2520 cct tcc cgc ccc tcc aca gtg gct aag ccc ctg ccg ccg gtg gcc 18159 Pro Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala 2525 2530 2535 gtg gcc cgc gcg cga ccc ggg ggc tcc gcc cgc cct cat gcg aac 18204 Val Ala Arg Ala Arg Pro Gly Gly Ser Ala Arg Pro His Ala Asn 2540 2545 2550 tgg cag agc act ctg aac agc atc gtg ggt ctg gga gtg cag agt 18249 Trp Gln Ser Thr Leu Asn Ser Ile Val Gly Leu Gly Val Gln Ser 2555 2560 2565 gtg aag cgc cgc cgc tgc tat taaacctacc gtagcgctta acttgcttgt 18300 Val Lys Arg Arg Arg Cys Tyr 2570 2575 ctgtgtgtgt atgtattatg tcgccgccgc tgtccgccag aaggaggagt gaagaggcgc 18360 gtcgccgagt tgcaag atg gcc acc cca tcg atg ctg ccc cag tgg gcg 18409 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala 2580 2585 tac atg cac atc gcc gga cag gac gct tcg gag tac ctg agt ccg 18454 Tyr Met His Ile Ala Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro 2590 2595 2600 ggt ctg gtg cag ttc gcc cgc gcc aca gac acc tac ttc agt ctg 18499 Gly Leu Val Gln Phe Ala Arg Ala Thr Asp Thr Tyr Phe Ser Leu 2605 2610 2615 ggg aac aag ttt agg aac ccc acg gtg gcg ccc acg cac gat gtg 18544 Gly Asn Lys Phe Arg Asn Pro Thr Val Ala Pro Thr His Asp Val 2620 2625 2630 acc acc gac cgc agc cag cgg ctg acg ctg cgc ttc gtg ccc gtg 18589 Thr Thr Asp Arg Ser Gln Arg Leu Thr Leu Arg Phe Val Pro Val 2635 2640 2645 gac cgc gag gac aac acc tac tcg tac aaa gtg cgc tac acg ctg 18634 Asp Arg Glu Asp Asn Thr Tyr Ser Tyr Lys Val Arg Tyr Thr Leu 2650 2655 2660 gcc gtg ggc gac aac cgc gtg ctg gac atg gcc agc acc tac ttt 18679 Ala Val Gly Asp Asn Arg Val Leu Asp Met Ala Ser Thr Tyr Phe 2665 2670 2675 gac atc cgc ggc gtg ctg gac cgg ggc cct agc ttc aaa ccc tac 18724 Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser Phe Lys Pro Tyr 2680 2685 2690 tcc ggc acc gcc tac aac agc ctg gct ccc aag gga gcg ccc aat 18769 Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly Ala Pro Asn 2695 2700 2705 tcc agc cag tgg gag cga gct aag aca aac aat aac gga gcc acg 18814 Ser Ser Gln Trp Glu Arg Ala Lys Thr Asn Asn Asn Gly Ala Thr 2710 2715 2720 gaa tct gtt acc ttt ggt gtg gct gcc atg ggg ggt ata gat att 18859 Glu Ser Val Thr Phe Gly Val Ala Ala Met Gly Gly Ile Asp Ile 2725 2730 2735 aca aaa gag ggt ctc cag att gga act gat gaa act aaa gct gat 18904 Thr Lys Glu Gly Leu Gln Ile Gly Thr Asp Glu Thr Lys Ala Asp 2740 2745 2750 agt aaa gaa att tat gca gac aaa acc tac caa cct gaa cct cag 18949 Ser Lys Glu Ile Tyr Ala Asp Lys Thr Tyr Gln Pro Glu Pro Gln 2755 2760 2765 ata gga gag gag aac tgg caa gaa aca ttc tcc tat tat ggc ggc 18994 Ile Gly Glu Glu Asn Trp Gln Glu Thr Phe Ser Tyr Tyr Gly Gly 2770 2775 2780 aga gct ctt aaa aaa gat acc aag atg aag cca tgc tac ggc tcc 19039 Arg Ala Leu Lys Lys Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser 2785 2790 2795 ttt gct aaa cca acg aat gtc aaa gga ggt cag gcc aaa ttt aaa 19084 Phe Ala Lys Pro Thr Asn Val Lys Gly Gly Gln Ala Lys Phe Lys 2800 2805 2810 gtt cag gac ggt caa caa act aca gaa tat gat atc gac tta gct 19129 Val Gln Asp Gly Gln Gln Thr Thr Glu Tyr Asp Ile Asp Leu Ala 2815 2820 2825 ttc ttt gat att cca aac tct gga aca gga ggg aat ggc acg aat 19174 Phe Phe Asp Ile Pro Asn Ser Gly Thr Gly Gly Asn Gly Thr Asn 2830 2835 2840 gtt aat tat gat cca gat atg gtc atg tac act gaa aat gtg gat 19219 Val Asn Tyr Asp Pro Asp Met Val Met Tyr Thr Glu Asn Val Asp 2845 2850 2855 ttg gag acc cct gat acc cac att gtt tac aaa cca ggg act tcc 19264 Leu Glu Thr Pro Asp Thr His Ile Val Tyr Lys Pro Gly Thr Ser 2860 2865 2870 gat gac agt tct gaa gca aac ttg ctt cag cag tcc atg cct aac 19309 Asp Asp Ser Ser Glu Ala Asn Leu Leu Gln Gln Ser Met Pro Asn 2875 2880 2885 aga ccc aac tat att ggg ttt aga gac aac ttt atc ggt ctc atg 19354 Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met 2890 2895 2900 tac tac aac agt act ggc aat atg ggt gtg ctg gct ggt cag gcc 19399 Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala 2905 2910 2915 tcc cag ctg aat gct gtg gtc gac ttg caa gac aga aac acc gag 19444 Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu 2920 2925 2930 cta tcc tac cag ctc ttg ctt gac tct ctg ggc gat aga acc cgg 19489 Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp Arg Thr Arg 2935 2940 2945 tat ttc agt atg tgg aac cag gcg gtg gac agt tat gac cct gat 19534 Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp 2950 2955 2960 gtg cgc att att gaa aac cat ggt gtg gaa gat gaa ctt ccc aac 19579 Val Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn 2965 2970 2975 tat tgc ttc cca ttg gat gga gct ggt act aat gct gtc tat cag 19624 Tyr Cys Phe Pro Leu Asp Gly Ala Gly Thr Asn Ala Val Tyr Gln 2980 2985 2990 ggt gtt aaa gca aaa act aat gga ggc gca gcc aat gga gat tgg 19669 Gly Val Lys Ala Lys Thr Asn Gly Gly Ala Ala Asn Gly Asp Trp 2995 3000 3005 gag caa gat aca gac gtg tca aac att aac cag ata tgc aag ggg 19714 Glu Gln Asp Thr Asp Val Ser Asn Ile Asn Gln Ile Cys Lys Gly 3010 3015 3020 aac atc tat gcc atg gaa atc aac ctc caa gcc aac ctg tgg aga 19759 Asn Ile Tyr Ala Met Glu Ile Asn Leu Gln Ala Asn Leu Trp Arg 3025 3030 3035 agt ttc ctc tac tcg aac gtg gcc ctg tac ctg ccc gat tct tac 19804 Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr 3040 3045 3050 aag tac acg ccg gcc aac atc acc ttg ccc acg aat acc aac acc 19849 Lys Tyr Thr Pro Ala Asn Ile Thr Leu Pro Thr Asn Thr Asn Thr 3055 3060 3065 tat gat tac atg aat ggg aga gtg gcg cct ccc tcg ttg gtg gat 19894 Tyr Asp Tyr Met Asn Gly Arg Val Ala Pro Pro Ser Leu Val Asp 3070 3075 3080 gcc tac atc aac atc ggg gcg cgc tgg tcg ctg gac ccc atg gac 19939 Ala Tyr Ile Asn Ile Gly Ala Arg Trp Ser Leu Asp Pro Met Asp 3085 3090 3095 aac gtc aat ccc ttc aac cac cac cgc aac gcg ggg ctg cgc tac 19984 Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr 3100 3105 3110 cgc tcc atg ctt ctg ggc aac ggg cgc ttc gtg ccc ttc cac atc 20029 Arg Ser Met Leu Leu Gly Asn Gly Arg Phe Val Pro Phe His Ile 3115 3120 3125 cag gtg ccc cag aaa ttt ttc gcc atc aag agc ctc ctg ctc ctg 20074 Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu Leu Leu Leu 3130 3135 3140 ccc ggg tcc tac acc tac gag tgg aac ttc cgc aag gac gtc aac 20119 Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn 3145 3150 3155 atg atc ctg cag agc tcc ctc ggc aac gac ctg cgc acg gac ggg 20164 Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Thr Asp Gly 3160 3165 3170 gcc tcc atc tcc ttc acc agc atc aac ctc tac gcc acc ttc ttc 20209 Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala Thr Phe Phe 3175 3180 3185 ccc atg gcg cac aac acg gcc tcc acg ctc gag gcc atg ctg cgc 20254 Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg 3190 3195 3200 aac gac acc aac gac cag tcc ttc aac gac tac ctc tcg gcg gcc 20299 Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala Ala 3205 3210 3215 aac atg ctc tac ccc atc cca gcc aac gcc acc aac gtg ccc atc 20344 Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Val Pro Ile 3220 3225 3230 tcc atc ccc tcg cgc aac tgg gcc gcc ttc cgc ggc tgg tcc ttc 20389 Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe 3235 3240 3245 acg cgt ctc aag acc aag gag acg ccc tcg ctg ggc tcc ggg ttc 20434 Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe 3250 3255 3260 gac ccc tac ttc gtc tac tcg ggc tcc atc ccc tac ctc gac ggc 20479 Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly 3265 3270 3275 acc ttc tac ctc aac cac acc ttc aag aag gtc tcc atc acc ttc 20524 Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe 3280 3285 3290 gac tcc tcc gtc agc tgg ccc ggc aac gac cgg ctc ctg acg ccc 20569 Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro 3295 3300 3305 aac gag ttc gaa atc aag cgc acc gtc gac ggc gag ggc tac aac 20614 Asn Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn 3310 3315 3320 gtg gcc cag tgc aac atg acc aag gac tgg ttc ctg gtc cag atg 20659 Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met 3325 3330 3335 ctg gcc cac tac aac atc ggc tac cag ggc ttc tac gtg ccc gag 20704 Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu 3340 3345 3350 ggc tac aag gac cgc atg tac tcc ttc ttc cgc aac ttc cag ccc 20749 Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro 3355 3360 3365 atg agc cgc cag gtg gtg gac gag gtc aac tac aag gac tac cag 20794 Met Ser Arg Gln Val Val Asp Glu Val Asn Tyr Lys Asp Tyr Gln 3370 3375 3380 gcc gtc acc ctg gcc tac cag cac aac aac tcg ggc ttc gtc ggc 20839 Ala Val Thr Leu Ala Tyr Gln His Asn Asn Ser Gly Phe Val Gly 3385 3390 3395 tac ctc gcg ccc acc atg cgc cag ggc cag ccc tac ccc gcc aac 20884 Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln Pro Tyr Pro Ala Asn 3400 3405 3410 tac ccg tac ccg ctc atc ggc aag agc gcc gtc acc agc gtc acc 20929 Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val Thr Ser Val Thr 3415 3420 3425 cag aaa aag ttc ctc tgc gac agg gtc atg tgg cgc atc ccc ttc 20974 Gln Lys Lys Phe Leu Cys Asp Arg Val Met Trp Arg Ile Pro Phe 3430 3435 3440 tcc agc aac ttc atg tcc atg ggc gcg ctc acc gac ctc ggc cag 21019 Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln 3445 3450 3455 aac atg ctc tat gcc aac tcc gcc cac gcg cta gac atg aat ttc 21064 Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Asn Phe 3460 3465 3470 gaa gtc gac ccc atg gat gag tcc acc ctt ctc tat gtt gtc ttc 21109 Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr Val Val Phe 3475 3480 3485 gaa gtc ttc gac gtc gtc cga gtg cac cag ccc cac cgc ggc gtc 21154 Glu Val Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val 3490 3495 3500 atc gag gcc gtc tac ctg cgc acc ccc ttc tcg gcc ggt aac gcc 21199 Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala 3505 3510 3515 acc acc taagctcttg cttcttgcaa g atg gct gag ccc acg ggc tcc ggc 21250 Thr Thr Met Ala Glu Pro Thr Gly Ser Gly 3520 3525 gag cag gag ctc agg gcc atc atc cgc gac ctg ggc tgc ggg ccc 21295 Glu Gln Glu Leu Arg Ala Ile Ile Arg Asp Leu Gly Cys Gly Pro 3530 3535 3540 tac ttc ctg ggc acc ttc gat aag cgc ttc ccg gga ttc atg gcc 21340 Tyr Phe Leu Gly Thr Phe Asp Lys Arg Phe Pro Gly Phe Met Ala 3545 3550 3555 ccg cac aag ctg gcc tgc gcc atc gtc aac acg gcc ggc cgc gag 21385 Pro His Lys Leu Ala Cys Ala Ile Val Asn Thr Ala Gly Arg Glu 3560 3565 3570 acc ggg ggc gag cac tgg ctg gcc ttc gcc tgg aac ccg cgc tcg 21430 Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp Asn Pro Arg Ser 3575 3580 3585 aac acc tgc tac ctc ttc gac ccc ttc ggg ttc tcg gac gag cgc 21475 Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser Asp Glu Arg 3590 3595 3600 ctc aag cag atc tac cag ttc gag tac gag ggc ctg ctg cgc cgc 21520 Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu Leu Arg Arg 3605 3610 3615 agc gcc ctg gcc acc gag gac cgc tgc gtc acc ctg gaa aag tcc 21565 Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu Lys Ser 3620 3625 3630 acc cag acc gtg cag ggt ccg cgc tcg gcc gcc tgc ggg ctc ttt 21610 Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu Phe 3635 3640 3645 tgc tgc atg ttc ctg cac gcc ttc gtg cac tgg ccc gac cgc ccc 21655 Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro 3650 3655 3660 atg gac aag aac ccc acc atg aac ttg ctg acg ggg gtg ccc aac 21700 Met Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn 3665 3670 3675 ggc atg ctc cag tcg ccc cag gtg gaa ccc acc ctg cgc cgc aac 21745 Gly Met Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn 3680 3685 3690 cag gag gcg ctc tac cgc ttc ctc aac gcc cac tcc gcc tac ttt 21790 Gln Glu Ala Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe 3695 3700 3705 cgc tcc cac cgc gcg cgc atc gag aag gcc acc gcc ttc gac cgc 21835 Arg Ser His Arg Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg 3710 3715 3720 atg aat caa gac atg taaaccgtgt gtgtatgtga atgctttatt cataataaac 21890 Met Asn Gln Asp Met 3725 agcacatgtt tatgccacct tctctgaggc tctgacttta tttagaaatc gaaggggttc 21950 tgccggctct cggcgtgccc cgcgggcagg gatacgttgc ggaactggta cttgggcagc 22010 cacttgaact cggggatcag cagcttcggc acggggaggt cggggaacga gtcgctccac 22070 agcttgcgcg tgagttgcag ggcgcccagc aggtcgggcg cggagatctt gaaatcgcag 22130 ttgggacccg cgttctgcgc gcgagagttg cggtacacgg ggttgcagca ctggaacacc 22190 atcagggccg ggtgcttcac gctcgccagc accgtcgcgt cggtgatgcc ctccacgtcc 22250 agatcctcgg cgttggccat cccgaagggg gtcatcttgc aggtctgccg ccccatgctg 22310 ggcacgcagc cgggcttgtg gttgcaatcg cagtgcaggg ggatcagcat catctgggcc 22370 tgctcggagc tcatgcccgg gtacatggcc ttcatgaaag cctccagctg gcggaaggcc 22430 tgctgcgcct tgccgccctc ggtgaagaag accccgcagg acttgctaga gaactggttg 22490 gtagcgcagc ccgcgtcgtg cacgcagcag cgcgcgtcgt tgttggccag ctgcaccacg 22550 ctgcgccccc agcggttctg ggtgatcttg gcccggtcgg ggttctcctt cagcgcgcgc 22610 tgcccgttct cgctcgccac atccatctcg atcgtgtgct ccttctggat catcacggtc 22670 ccgtgcaggc accgcagctt gccctcggcc tcggtgcagc cgtgcagcca cagcgcgcag 22730 ccggtgctct cccagttctt gtgggcgatc tgggagtgcg agtgcacgaa gccctgcagg 22790 aagcggccca tcatcgcggt cagggtcttg ttgctggtga aggtcagcgg gatgccgcgg 22850 tgctcctcgt tcacatacag gtggcagatg cggcggtaca cctcgccctg ctcgggcatc 22910 agctggaagg cggacttcag gtcgctctcc acgcggtacc ggtccatcag cagcgtcatc 22970 acttccatgc ccttctccca ggccgaaacg atcggcaggc tcagggggtt cttcaccgtc 23030 atcttagtcg ccgccgccga agtcaggggg tcgttctcgt ccagggtctc aaacactcgc 23090 ttgccgtcct tctcggtgat gcgcacgggg gggaaggcga agcccacggc cgccagctcc 23150 tcctcggcct gcctttcgtc ctcgctgtcc tggctgatgt cttgcaaagg cacatgcttg 23210 gtcttgcggg gtttcttttt gggcggcaga ggcggcggcg gcggagacgt gctgggcgag 23270 cgcgagttct cgctcaccac gactatttct tcttcttggc cgtcgtccga gaccacgcgg 23330 cggtaggcat gcctcttctg gggcagaggc ggaggcgacg ggctctcgcg gttcggcggg 23390 cggctggcag agccccttcc gcgttcgggg gtgcgctcct ggcggcgctg ctctgactga 23450 cttcctccgc ggccggccat tgtgttctcc tagggagcaa caacaagc atg gag act 23507 Met Glu Thr cag cca tcg tcg cca aca tcg cca tct gcc ccc gcc gcc gcc gac 23552 Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ala Ala Asp 3730 3735 3740 gag aac cag cag cag cag aat gaa agc tta acc gcc ccg ccg ccc 23597 Glu Asn Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro Pro 3745 3750 3755 agc ccc acc tcc gac gcc gcg gcc cca gac atg caa gag atg gag 23642 Ser Pro Thr Ser Asp Ala Ala Ala Pro Asp Met Gln Glu Met Glu 3760 3765 3770 gaa tcc atc gag att gac ctg ggc tac gtg acg ccc gcg gag cac 23687 Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His 3775 3780 3785 gag gag gag ctg gca gcg cgc ttt tca gcc ccg gaa gag aac cac 23732 Glu Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His 3790 3795 3800 caa gag cag cca gag cag gaa gca gag agc gag cag agc cag gct 23777 Gln Glu Gln Pro Glu Gln Glu Ala Glu Ser Glu Gln Ser Gln Ala 3805 3810 3815 ggg ctc gag cat ggc gac tac ctg agc ggg gca gag gac gtg ctc 23822 Gly Leu Glu His Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu 3820 3825 3830 atc aag cat ctg gcc cgc caa tgc atc atc gtc aag gac gcg ctg 23867 Ile Lys His Leu Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu 3835 3840 3845 ctc gac cgc gcc gag gtg ccc ctc agc gtg gcg gag ctc agc cgc 23912 Leu Asp Arg Ala Glu Val Pro Leu Ser Val Ala Glu Leu Ser Arg 3850 3855 3860 gcc tac gag cgc aac ctc ttc tcg ccg cgc gtg ccc ccc aag cgc 23957 Ala Tyr Glu Arg Asn Leu Phe Ser Pro Arg Val Pro Pro Lys Arg 3865 3870 3875 cag ccc aac ggc acc tgc gag ccc aac ccg cgc ctc aac ttc tac 24002 Gln Pro Asn Gly Thr Cys Glu Pro Asn Pro Arg Leu Asn Phe Tyr 3880 3885 3890 ccg gtc ttc gcg gtg ccc gag gcc ctg gcc acc tac cac ctc ttt 24047 Pro Val Phe Ala Val Pro Glu Ala Leu Ala Thr Tyr His Leu Phe 3895 3900 3905 ttc aag aac caa agg atc ccc gtc tcc tgc cgc gcc aac cgc acc 24092 Phe Lys Asn Gln Arg Ile Pro Val Ser Cys Arg Ala Asn Arg Thr 3910 3915 3920 cgc gcc gac gcc ctg ctc aac ctg ggc ccc ggc gcc cgc cta cct 24137 Arg Ala Asp Ala Leu Leu Asn Leu Gly Pro Gly Ala Arg Leu Pro 3925 3930 3935 gat atc gcc tcc ttg gaa gag gtt ccc aag atc ttc gag ggt ctg 24182 Asp Ile Ala Ser Leu Glu Glu Val Pro Lys Ile Phe Glu Gly Leu 3940 3945 3950 ggc agc gac gag act cgg gcc gcg aac gct ctg caa gga agc gga 24227 Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu Gln Gly Ser Gly 3955 3960 3965 gag gag cat gag cac cac agc gcc ctg gtg gag ttg gaa ggc gac 24272 Glu Glu His Glu His His Ser Ala Leu Val Glu Leu Glu Gly Asp 3970 3975 3980 aac gcg cgc ctg gcg gtc ctc aag cgc acg gtc gag ctg acc cac 24317 Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu Thr His 3985 3990 3995 ttc gcc tac ccg gcg ctc aac ctg ccc ccc aag gtc atg agc gcc 24362 Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser Ala 4000 4005 4010 gtc atg gac cag gtg ctc atc aag cgc gcc tcg ccc ctc tcg gag 24407 Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu 4015 4020 4025 gag gag atg cag gac ccc gag agc tcg gac gag ggc aag ccc gtg 24452 Glu Glu Met Gln Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val 4030 4035 4040 gtc agc gac gag cag ctg gcg cgc tgg ctg gga acg agt agc acc 24497 Val Ser Asp Glu Gln Leu Ala Arg Trp Leu Gly Thr Ser Ser Thr 4045 4050 4055 ccc cag agt ctg gaa gag cgg cgc aag ctc atg atg gcc gtg gtc 24542 Pro Gln Ser Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val 4060 4065 4070 ctg gtg acc gtg gag ctt gag tgt ctg cgc cgc ttc ttc gcc gac 24587 Leu Val Thr Val Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp 4075 4080 4085 gcg gag acc ctg cgc aag gtc gag gag aac ctg cac tac ctc ttc 24632 Ala Glu Thr Leu Arg Lys Val Glu Glu Asn Leu His Tyr Leu Phe 4090 4095 4100 agg cac ggg ttc gtg cgc cag gcc tgc aag atc tcc aac gtg gag 24677 Arg His Gly Phe Val Arg Gln Ala Cys Lys Ile Ser Asn Val Glu 4105 4110 4115 ctg acc aac ctg gtc tcc tac atg ggc atc ctg cac gag aac cgc 24722 Leu Thr Asn Leu Val Ser Tyr Met Gly Ile Leu His Glu Asn Arg 4120 4125 4130 ctg ggg cag aac gtg ctg cac acc acc ctg cgc ggg gag gcc cgc 24767 Leu Gly Gln Asn Val Leu His Thr Thr Leu Arg Gly Glu Ala Arg 4135 4140 4145 cgc gac tac atc cgc gac tgc gtc tac ctg tac ctc tgc cac acc 24812 Arg Asp Tyr Ile Arg Asp Cys Val Tyr Leu Tyr Leu Cys His Thr 4150 4155 4160 tgg cag acg ggc atg ggc gtg tgg cag cag tgc ctg gag gag cag 24857 Trp Gln Thr Gly Met Gly Val Trp Gln Gln Cys Leu Glu Glu Gln 4165 4170 4175 aac ctg aaa gag ctc tgc aag ctc ctg cag aag aac ctg aag gcc 24902 Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys Asn Leu Lys Ala 4180 4185 4190 ctg tgg acc ggg ttc gac gag cgt acc acc gcc tcg gac ctg gcc 24947 Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser Asp Leu Ala 4195 4200 4205 gac ctc atc ttc ccc gag cgc ctg cgg ctg acg ctg cgc aac ggg 24992 Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg Asn Gly 4210 4215 4220 ctg ccc gac ttt atg agc caa agc atg ttg caa aac ttt cgc tct 25037 Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg Ser 4225 4230 4235 ttc atc ctc gaa cgc tcc ggg atc ctg ccc gcc acc tgc tcc gcg 25082 Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala 4240 4245 4250 ctg ccc tcg gac ttc gtg ccg ctg acc ttc cgc gag tgc ccc ccg 25127 Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro 4255 4260 4265 ccg ctc tgg agc cac tgc tac ttg ctg cgc ctg gcc aac tac ctg 25172 Pro Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu 4270 4275 4280 gcc tac cac tcg gac gtg atc gag gac gtc agc ggc gag ggt ctg 25217 Ala Tyr His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu 4285 4290 4295 ctc gag tgc cac tgc cgc tgc aac ctc tgc acg ccg cac cgc tcc 25262 Leu Glu Cys His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser 4300 4305 4310 ctg gcc tgc aac ccc cag ctg ctg agc gag acc cag atc atc ggc 25307 Leu Ala Cys Asn Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly 4315 4320 4325 acc ttc gag ttg caa ggc ccc ggc gag gag ggc aag ggg ggt ctg 25352 Thr Phe Glu Leu Gln Gly Pro Gly Glu Glu Gly Lys Gly Gly Leu 4330 4335 4340 aaa ctc acc ccg ggg ctg tgg acc tcg gcc tac ttg cgc aag ttc 25397 Lys Leu Thr Pro Gly Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe 4345 4350 4355 gtg ccc gag gac tac cat ccc ttc gag atc agg ttc tac gag gac 25442 Val Pro Glu Asp Tyr His Pro Phe Glu Ile Arg Phe Tyr Glu Asp 4360 4365 4370 caa tcc cag ccg ccc aag gcc gag ctg tcg gcc tgc gtc atc acc 25487 Gln Ser Gln Pro Pro Lys Ala Glu Leu Ser Ala Cys Val Ile Thr 4375 4380 4385 cag ggg gcc atc ctg gcc caa ttg caa gcc atc cag aaa tcc cgc 25532 Gln Gly Ala Ile Leu Ala Gln Leu Gln Ala Ile Gln Lys Ser Arg 4390 4395 4400 caa gaa ttt ctg ctg aaa aag ggc cac ggg gtc tac ttg gac ccc 25577 Gln Glu Phe Leu Leu Lys Lys Gly His Gly Val Tyr Leu Asp Pro 4405 4410 4415 cag acc gga gag gag ctc aac ccc agc ttc ccc cag gat gcc cag 25622 Gln Thr Gly Glu Glu Leu Asn Pro Ser Phe Pro Gln Asp Ala Gln 4420 4425 4430 agg aag cag caa gaa gct gaa agt gga gct gcc gct gcc gcc gga 25667 Arg Lys Gln Gln Glu Ala Glu Ser Gly Ala Ala Ala Ala Ala Gly 4435 4440 4445 gga ttt gga gga aga ctg gga gag cag tca ggc aga gga gga gga 25712 Gly Phe Gly Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly Gly Gly 4450 4455 4460 gat gga aga ctg gga cag cac tca ggc aga gga gga cag cct gca 25757 Asp Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln Pro Ala 4465 4470 4475 aga cag tct gga aga cga ggt gga gga ggc aga gga aga agc agc 25802 Arg Gln Ser Gly Arg Arg Gly Gly Gly Gly Arg Gly Arg Ser Ser 4480 4485 4490 cgc cgc cag acc gtc gtc ctc ggc gga gaa agc aag cag cac gga 25847 Arg Arg Gln Thr Val Val Leu Gly Gly Glu Ser Lys Gln His Gly 4495 4500 4505 tac cat ctc cgc tcc ggg tcg ggg tct cgg cgg ccg ggc cca cag 25892 Tyr His Leu Arg Ser Gly Ser Gly Ser Arg Arg Pro Gly Pro Gln 4510 4515 4520 tagatgggac gagaccgggc gcttcccgaa ccccaccacc cagaccggta agaaggagcg 25952 gcagggatac aagtcctggc gggggcacaa aaacgccatc gtctcctgct tgcaagcctg 26012 cgggggcaac atctccttca cccggcgcta cctgctcttc caccgcgggg tgaacttccc 26072 ccgcaacatc ttgcattact accgtcacct ccacagcccc tactactgtt tccaagaaga 26132 ggcagaaacc cagcagcagc agaaaaccag cagcagctag aaaatccaca gcggcggcgg 26192 cggcaggtgg actgaggatc gcggcgaacg agccggcgca gacccgggag ctgaggaacc 26252 ggatctttcc caccctctat gccatcttcc agcagagtcg ggggcaggag caggaactga 26312 aagtcaagaa ccgttctctg cgctcgctca cccgcagttg tctgtatcac aagagcgaag 26372 accaacttca gcgcactctc gaggacgccg aggctctctt caacaagtac tgcgcgctca 26432 ctcttaaaga gtagcccgcg cccgcccaca cacggaaaaa ggcgggaatt acgtcaccac 26492 ctgcgccctt cgcccgacca tcatc atg agc aaa gag att ccc acg cct tac 26544 Met Ser Lys Glu Ile Pro Thr Pro Tyr 4525 4530 atg tgg agc tac cag ccc cag atg ggc ctg gcc gcc ggc gcc gcc 26589 Met Trp Ser Tyr Gln Pro Gln Met Gly Leu Ala Ala Gly Ala Ala 4535 4540 4545 cag gac tac tcc acc cgc atg aac tgg ctc agt gcc ggg ccc gcg 26634 Gln Asp Tyr Ser Thr Arg Met Asn Trp Leu Ser Ala Gly Pro Ala 4550 4555 4560 atg atc tca cgg gtg aat gac atc cgc gcc cac cga aac cag ata 26679 Met Ile Ser Arg Val Asn Asp Ile Arg Ala His Arg Asn Gln Ile 4565 4570 4575 ctc cta gaa cag tca gcg atc acc gcc acg ccc cgc cat cac ctt 26724 Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr Pro Arg His His Leu 4580 4585 4590 aat ccg cgt aat tgg ccc gcc gcc ctg gtg tac cag gaa att ccc 26769 Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr Gln Glu Ile Pro 4595 4600 4605 cag ccc acg acc gta cta ctt ccg cga gac gcc cag gcc gaa gtc 26814 Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln Ala Glu Val 4610 4615 4620 cag ctg act aac tca ggt gtc cag ctg gcc ggc ggc gcc gcc ctg 26859 Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala Ala Leu 4625 4630 4635 tgt cgt cac cgc ccc gct cag ggt ata aag cgg ctg gtg atc cga 26904 Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile Arg 4640 4645 4650 ggc aga ggc aca cag ctc aac gac gag gtg gtg agc tct tcg ctg 26949 Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 4655 4660 4665 ggt ctg cga cct gac gga gtc ttc caa ctc gcc gga tcg ggg aga 26994 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg 4670 4675 4680 tct tcc ttc acg cct cgt cag gcc gtc ctg act ttg gag agt tcg 27039 Ser Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser 4685 4690 4695 tcc tcg cag ccc cgc tcg ggt ggc atc ggc act ctc cag ttc gtg 27084 Ser Ser Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val 4700 4705 4710 gag gag ttc act ccc tcg gtc tac ttc aac ccc ttc tcc ggc tcc 27129 Glu Glu Phe Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser 4715 4720 4725 ccc ggc cac tac ccg gac gag ttc atc ccg aac ttc gac gcc atc 27174 Pro Gly His Tyr Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile 4730 4735 4740 agc gag tcg gtg gac ggc tac gat tga atg tcc cat ggt ggc gcg 27219 Ser Glu Ser Val Asp Gly Tyr Asp Met Ser His Gly Gly Ala 4745 4750 4755 gct gac cta gct cgg ctt cga cac ctg gac cac tgc cgc cgc ttc 27264 Ala Asp Leu Ala Arg Leu Arg His Leu Asp His Cys Arg Arg Phe 4760 4765 4770 cgc tgc ttc gct cgg gat ctc gcc gag ttt gcc tac ttt gag ctg 27309 Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Ala Tyr Phe Glu Leu 4775 4780 4785 ccc gag gag cac cct cag ggc ccg gcc cac gga gtg cgg atc atc 27354 Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val Arg Ile Ile 4790 4795 4800 gtc gaa ggg ggc ctc gac tcc cac ctg ctt cgg atc ttc agc cag 27399 Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe Ser Gln 4805 4810 4815 cgt ccg atc ctg gtc gag cgc gag caa gga cag acc cgt ctg acc 27444 Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Arg Leu Thr 4820 4825 4830 ctg tac tgc atc tgc aac cac ccc ggc ctg cat gaa agt ctt tgt 27489 Leu Tyr Cys Ile Cys Asn His Pro Gly Leu His Glu Ser Leu Cys 4835 4840 4845 tgt ctg ctg tgt act gag tat aat aaa agc tgagatcagc gactactccg 27539 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 4850 4855 gacttccgtg tgttcctgaa tccatcaacc agtccctgtt cttcaccggg aacgagaccg 27599 agctccagct ccagtgtaag ccccacaaga agtacctcac ctggctgttc cagggctccc 27659 cgatcgccgt tgtcaaccac tgcgacaacg acggagtcct gctgagcggc cctgccaacc 27719 ttactttttc cacccgcaga agcaagctcc agctcttcca acccttcctc cccgggacct 27779 atcagtgcgt ctcgggaccc tgccatcaca ccttccacct gatcccgaat accacagcgt 27839 cgctccccgc tactaacaac caaactaccc accaacgcca ccgtcgcgac ctttcctctg 27899 aatctaatac cactaccgga ggtgagctcc gaggtcgacc aacctctggg atttactacg 27959 gcccctggga ggtggtgggg ttaatagcgc taggcctagt tgtgggtggg cttttggctc 28019 tctgctacct atacctccct tgctgttcgt acttagtggt gctgtgttgc tggtttaaga 28079 a atg ggg cag atc acc cta gtg agc tgc ggt gtg ctg gtg gcg gtg 28125 Met Gly Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val 4860 4865 4870 gtg ctt tcg att gtg gga ctg ggc ggc gcg gct gta gtg aag gag 28170 Val Leu Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu 4875 4880 4885 aag gcc gat ccc tgc ttg cat ttc aat ccc gat aaa tgc cag ctg 28215 Lys Ala Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu 4890 4895 4900 agt ttt cag ccc gat ggc aat cgg tgc gcg gtg ctg atc aag tgc 28260 Ser Phe Gln Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys 4905 4910 4915 gga tgg gaa tgc gag aac gtg aga atc gag tac aat aac aag act 28305 Gly Trp Glu Cys Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr 4920 4925 4930 cgg aac aat act ctc gcg tcc acg tgg cag ccc ggg gac ccc gag 28350 Arg Asn Asn Thr Leu Ala Ser Thr Trp Gln Pro Gly Asp Pro Glu 4935 4940 4945 tgg tac acc gtc tct gtc ccc ggt gct gac ggc tcc ccg cgc acc 28395 Trp Tyr Thr Val Ser Val Pro Gly Ala Asp Gly Ser Pro Arg Thr 4950 4955 4960 gtg aat aat act ttc att ttt gcg cac atg tgc gac acg gtc atg 28440 Val Asn Asn Thr Phe Ile Phe Ala His Met Cys Asp Thr Val Met 4965 4970 4975 tgg atg agc aag cag tac gat atg tgg ccc ccc acg aag gag aac 28485 Trp Met Ser Lys Gln Tyr Asp Met Trp Pro Pro Thr Lys Glu Asn 4980 4985 4990 atc gtg gtc ttc tcc atc gct tac agc ctg tgc acg gtg cta atc 28530 Ile Val Val Phe Ser Ile Ala Tyr Ser Leu Cys Thr Val Leu Ile 4995 5000 5005 acc gct atc gtg tgc ctg agc att cac atg ctc atc gct att cgc 28575 Thr Ala Ile Val Cys Leu Ser Ile His Met Leu Ile Ala Ile Arg 5010 5015 5020 ccc aga aat aat gcc gaa aaa gaa aaa cag cca taacacgttt 28618 Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 5025 5030 tttcacacac ctttttcaga cc atg gcc tct gtt aaa ttt ttg ctt tta 28667 Met Ala Ser Val Lys Phe Leu Leu Leu 5035 5040 ttt gcc agt ctc att act gtt ata agt aat gag aaa ctc act att 28712 Phe Ala Ser Leu Ile Thr Val Ile Ser Asn Glu Lys Leu Thr Ile 5045 5050 5055 tac att ggc act aac cac act cta gaa gga att cca aaa tcc tca 28757 Tyr Ile Gly Thr Asn His Thr Leu Glu Gly Ile Pro Lys Ser Ser 5060 5065 5070 tgg tat tgc tat ttt gat caa gat cca gac tta act ata gaa ctg 28802 Trp Tyr Cys Tyr Phe Asp Gln Asp Pro Asp Leu Thr Ile Glu Leu 5075 5080 5085 tgt ggt aac aag gga caa aat aca agc att cat tta att aac ttt 28847 Cys Gly Asn Lys Gly Gln Asn Thr Ser Ile His Leu Ile Asn Phe 5090 5095 5100 aaa tgc gga gac gat ttg aaa tta att aat atc act aaa gag tat 28892 Lys Cys Gly Asp Asp Leu Lys Leu Ile Asn Ile Thr Lys Glu Tyr 5105 5110 5115 gga ggt atg tat tac tat gtt aca gaa aat aac aac atg cag ttt 28937 Gly Gly Met Tyr Tyr Tyr Val Thr Glu Asn Asn Asn Met Gln Phe 5120 5125 5130 tat gaa gtt act gta act aat ccc acc acg cct aga aca aca aca 28982 Tyr Glu Val Thr Val Thr Asn Pro Thr Thr Pro Arg Thr Thr Thr 5135 5140 5145 acc acc aca aag act aca cct gtt acc act atg cag ctc act acc 29027 Thr Thr Thr Lys Thr Thr Pro Val Thr Thr Met Gln Leu Thr Thr 5150 5155 5160 aat aac att ttt gcc atg cgt cag aag gcc aac aat agc acc agc 29072 Asn Asn Ile Phe Ala Met Arg Gln Lys Ala Asn Asn Ser Thr Ser 5165 5170 5175 att caa ccc ccc cca ccc agt gag gaa att ccc aaa tcc atg att 29117 Ile Gln Pro Pro Pro Pro Ser Glu Glu Ile Pro Lys Ser Met Ile 5180 5185 5190 ggc att att gtt gct gta gtg gtg tgc atg ttg atc atc gcc ttg 29162 Gly Ile Ile Val Ala Val Val Val Cys Met Leu Ile Ile Ala Leu 5195 5200 5205 tgc atg gtg tac tat gcc ttc tgc tac aga aag cac aga ctg aac 29207 Cys Met Val Tyr Tyr Ala Phe Cys Tyr Arg Lys His Arg Leu Asn 5210 5215 5220 gac aag cta gaa cac tta cta agt gtt gaa ttt taattttttt agaacc 29256 Asp Lys Leu Glu His Leu Leu Ser Val Glu Phe 5225 5230 atg aag atc cta ggc ctt tta att ttt tct atc att acc tct gct 29301 Met Lys Ile Leu Gly Leu Leu Ile Phe Ser Ile Ile Thr Ser Ala 5235 5240 5245 cta tgc aat tct gac aat gag gac gtt act gtc gtt gtc gga tca 29346 Leu Cys Asn Ser Asp Asn Glu Asp Val Thr Val Val Val Gly Ser 5250 5255 5260 aat tat aca ctg aaa ggt cca gcg aag ggt atg ctt tcg tgg tat 29391 Asn Tyr Thr Leu Lys Gly Pro Ala Lys Gly Met Leu Ser Trp Tyr 5265 5270 5275 tgc tgg ttt gga act gac act gaa caa acc gaa tta tgc aat ctt 29436 Cys Trp Phe Gly Thr Asp Thr Glu Gln Thr Glu Leu Cys Asn Leu 5280 5285 5290 caa aat ggc aaa gtt cat aat tct aaa att tac aat tat ata tgc 29481 Gln Asn Gly Lys Val His Asn Ser Lys Ile Tyr Asn Tyr Ile Cys 5295 5300 5305 aat ggc act gat ttg ata ctc ctc aat atc acg aaa tca tat gct 29526 Asn Gly Thr Asp Leu Ile Leu Leu Asn Ile Thr Lys Ser Tyr Ala 5310 5315 5320 ggc agt tat tca tgc cct gga gat gat gct gac aat atg att ttt 29571 Gly Ser Tyr Ser Cys Pro Gly Asp Asp Ala Asp Asn Met Ile Phe 5325 5330 5335 tat aaa ttg caa gtg gtt gat ccc act act cca cct cca ccc acc 29616 Tyr Lys Leu Gln Val Val Asp Pro Thr Thr Pro Pro Pro Pro Thr 5340 5345 5350 aca act act cac acc aca cac aca gaa caa acc aca gca gag gag 29661 Thr Thr Thr His Thr Thr His Thr Glu Gln Thr Thr Ala Glu Glu 5355 5360 5365 gcg gca aag tta gct ttg cag gtc caa gac agt tca ttt gtt ggc 29706 Ala Ala Lys Leu Ala Leu Gln Val Gln Asp Ser Ser Phe Val Gly 5370 5375 5380 att acc cct aca ccc gat cag cgg tgt ccg ggg ctg ctc gtc agc 29751 Ile Thr Pro Thr Pro Asp Gln Arg Cys Pro Gly Leu Leu Val Ser 5385 5390 5395 ggc att gtc ggt gtg ctt tcg gga tta gca gtt ata atc atc tgc 29796 Gly Ile Val Gly Val Leu Ser Gly Leu Ala Val Ile Ile Ile Cys 5400 5405 5410 atg ttc att ttt gct tgc tgc tat aga agg ctt tac cga caa aaa 29841 Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr Arg Gln Lys 5415 5420 5425 tca gac cca ctg ctg aac ctc tat gtt taattttttc cagagcc atg aag 29891 Ser Asp Pro Leu Leu Asn Leu Tyr Val Met Lys 5430 5435 gca gtt agc gct cta gtt ttt tgt tct ttg att ggc act gtt ttt 29936 Ala Val Ser Ala Leu Val Phe Cys Ser Leu Ile Gly Thr Val Phe 5440 5445 5450 agt gtt agc ttt tta aaa caa att aat gtt act gag ggg gaa aat 29981 Ser Val Ser Phe Leu Lys Gln Ile Asn Val Thr Glu Gly Glu Asn 5455 5460 5465 gtg aca ctg gta ggc gta gaa ggt gct caa aat acc acc tgg aca 30026 Val Thr Leu Val Gly Val Glu Gly Ala Gln Asn Thr Thr Trp Thr 5470 5475 5480 aaa tac cac ctc gat ggg tgg aaa gat att tgc aat tgg agt gtc 30071 Lys Tyr His Leu Asp Gly Trp Lys Asp Ile Cys Asn Trp Ser Val 5485 5490 5495 att act tac aca tgt gag gga gtt aat ttg acc ata gtc aat gcc 30116 Ile Thr Tyr Thr Cys Glu Gly Val Asn Leu Thr Ile Val Asn Ala 5500 5505 5510 agc caa aat cag aag ggt tgg att aaa ggg caa tct gtt agt gtt 30161 Ser Gln Asn Gln Lys Gly Trp Ile Lys Gly Gln Ser Val Ser Val 5515 5520 5525 acc agt gag ggg tac tat acc cag cat act ctt atc tat gac att 30206 Thr Ser Glu Gly Tyr Tyr Thr Gln His Thr Leu Ile Tyr Asp Ile 5530 5535 5540 ata gtc ata ccg ctg cct acg cct agc cca cct agc act acc aca 30251 Ile Val Ile Pro Leu Pro Thr Pro Ser Pro Pro Ser Thr Thr Thr 5545 5550 5555 cag aca acc cac act aca caa aca acc aca tac agt aca tca aat 30296 Gln Thr Thr His Thr Thr Gln Thr Thr Thr Tyr Ser Thr Ser Asn 5560 5565 5570 cag cct acc acc act aca aca gca gag gtt gcc agc tcg tct ggg 30341 Gln Pro Thr Thr Thr Thr Thr Ala Glu Val Ala Ser Ser Ser Gly 5575 5580 5585 gtc cga gcg gca ttt ttg atg ttg gcc cca tct agc agt ccc act 30386 Val Arg Ala Ala Phe Leu Met Leu Ala Pro Ser Ser Ser Pro Thr 5590 5595 5600 gct agt acc aat gag cag act act gaa ttt ttg tcc act gtc gag 30431 Ala Ser Thr Asn Glu Gln Thr Thr Glu Phe Leu Ser Thr Val Glu 5605 5610 5615 agc cac acc aca gct acc tcg agt gcc ttc tct agc acc gcc aat 30476 Ser His Thr Thr Ala Thr Ser Ser Ala Phe Ser Ser Thr Ala Asn 5620 5625 5630 ctc tcc tcg ctt tcc tct aca cca atc agt ccc gct act act act 30521 Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro Ala Thr Thr Thr 5635 5640 5645 acc ccc gct att ctt ccc act ccc ctg aag caa act gag gac agc 30566 Thr Pro Ala Ile Leu Pro Thr Pro Leu Lys Gln Thr Glu Asp Ser 5650 5655 5660 ggc atg caa tgg cag atc acc ctg ctc att gtg atc ggg ttg gtc 30611 Gly Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly Leu Val 5665 5670 5675 atc cta gcc gtg ttg ctc tac tac atc ttc cgc cgc cgc att ccc 30656 Ile Leu Ala Val Leu Leu Tyr Tyr Ile Phe Arg Arg Arg Ile Pro 5680 5685 5690 aac gcg cac cgc aag ccg gtc tac aag ccc atc att gtc ggg cag 30701 Asn Ala His Arg Lys Pro Val Tyr Lys Pro Ile Ile Val Gly Gln 5695 5700 5705 ccg gag ccg ctt cag gtg gaa ggg ggt cta agg aat ctt ctc ttc 30746 Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe 5710 5715 5720 tct ttt aca gta tgg tgattgaact atgattccta gacaattctt gatcactatt 30801 Ser Phe Thr Val Trp 5725 cttatctgcc tcctccaagt ctgtgccacc ctcgctctgg tggccaacgc cagtccagac 30861 tgtattgggc ccttcgcctc ctacgtgctc tttgccttca tcacctgcat ctgctgctgt 30921 agcatagtct gcctgcttat caccttcttc cagttcattg actggatctt tgtgcgcatc 30981 gcctacctgc gccaccaccc ccagtaccgc gaccagcgag tggcgcagct gctcaggctc 31041 ctctgataag c atg cgg gct ctg cta ctt ctc gcg ctt ctg ctg tta 31088 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu 5730 5735 5740 gtg ctc ccc cgt ccc gtt gac ccc cgg ccc ccc act cag tcc ccc 31133 Val Leu Pro Arg Pro Val Asp Pro Arg Pro Pro Thr Gln Ser Pro 5745 5750 5755 gag gag gtc cgc aaa tgc aaa ttc caa gaa ccc tgg aaa ttc ctc 31178 Glu Glu Val Arg Lys Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu 5760 5765 5770 aaa tgc tac cgc caa aaa tca gac atg cat ccc agc tgg atc atg 31223 Lys Cys Tyr Arg Gln Lys Ser Asp Met His Pro Ser Trp Ile Met 5775 5780 5785 atc att ggg atc gtg aac att ctg gcc tgc acc ctc atc tcc ttt 31268 Ile Ile Gly Ile Val Asn Ile Leu Ala Cys Thr Leu Ile Ser Phe 5790 5795 5800 gtg att tac ccc tgc ttt gac ttt ggt tgg aac tcg cca gag gcg 31313 Val Ile Tyr Pro Cys Phe Asp Phe Gly Trp Asn Ser Pro Glu Ala 5805 5810 5815 ctc tat ctc ccg cct gaa cct gac aca cca cca cag caa cct cag 31358 Leu Tyr Leu Pro Pro Glu Pro Asp Thr Pro Pro Gln Gln Pro Gln 5820 5825 5830 gca cac gca cta cca cca cca cag cct agg cca caa tac atg ccc 31403 Ala His Ala Leu Pro Pro Pro Gln Pro Arg Pro Gln Tyr Met Pro 5835 5840 5845 ata tta gac tat gag gcc gag cca cag cga ccc atg ctc ccc gct 31448 Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg Pro Met Leu Pro Ala 5850 5855 5860 att agt tac ttc aat cta acc ggc gga gat gac tgacccactg 31491 Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 5865 5870 gccaacaaca acgtcaacga ccttctcctg gacatggacg gccgcgcctc ggagcagcga 31551 ctcgcccaac ttcgcattcg ccagcagcag gagagagccg tcaaggagct gcaggacggc 31611 atagccatcc accagtgcaa gaaaggcatc ttctgcctgg tgaaacaggc caagatctcc 31671 tacgaggtca cccagaccga ccatcgcctc tcctacgagc tcctgcagca gcgccagaag 31731 ttcacctgcc tggtcggagt caaccccatc gtcatcaccc agcagtcggg cgataccaag 31791 gggtgcatcc actgctcctg cgactccccc gactgcgtcc acactctgat caagaccctc 31851 tgcggcctcc gcgacctcct ccccatgaac taatcacccc cttatccagt gaaataaaga 31911 tcatattgat gattaaataa aaaaaataat catttgattt gaaataaaga tacaatcata 31971 ttgatgattt gagtttaata aaaataaaga atcacttact tgaaatctga taccaggtct 32031 ctgtccatgt tttctgccaa caccacttca ctcccctctt cccagctctg gtactgcagg 32091 ccccggcggg ctgcaaactt cctccacacc ctgaagggga tgtcaaattc ctcctgtccc 32151 tcaatcttca ttttatcttc tatcag atg tcc aaa aag cgc gtc cgg gtg 32201 Met Ser Lys Lys Arg Val Arg Val 5875 5880 gat gat gac ttc gac ccc gtc tac ccc tac gat gca gac aac gca 32246 Asp Asp Asp Phe Asp Pro Val Tyr Pro Tyr Asp Ala Asp Asn Ala 5885 5890 5895 ccg acc gtg ccc ttc atc aac ccc ccc ttc gtc tct tca gat gga 32291 Pro Thr Val Pro Phe Ile Asn Pro Pro Phe Val Ser Ser Asp Gly 5900 5905 5910 ttc caa gag aag ccc ctg ggg gtg ctg tcc ctg cgt ctg gcc gat 32336 Phe Gln Glu Lys Pro Leu Gly Val Leu Ser Leu Arg Leu Ala Asp 5915 5920 5925 ccc gtc acc acc aag aac ggg gaa atc acc ctc aag ctg gga gat 32381 Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu Lys Leu Gly Asp 5930 5935 5940 ggg gtg gac ctc gac tcc tcg gga aaa ctc atc tcc aac acg gcc 32426 Gly Val Asp Leu Asp Ser Ser Gly Lys Leu Ile Ser Asn Thr Ala 5945 5950 5955 acc aag gcc gcc gcc cct ctc agt ttt tcc aac aac acc att tcc 32471 Thr Lys Ala Ala Ala Pro Leu Ser Phe Ser Asn Asn Thr Ile Ser 5960 5965 5970 ctt aac atg gat acc cct ttt tac aac aac aat gga aag tta ggc 32516 Leu Asn Met Asp Thr Pro Phe Tyr Asn Asn Asn Gly Lys Leu Gly 5975 5980 5985 atg aaa gtc act gct cca ctg aag ata cta gac aca gac ttg cta 32561 Met Lys Val Thr Ala Pro Leu Lys Ile Leu Asp Thr Asp Leu Leu 5990 5995 6000 aaa aca ctt gtt gta gct tat gga caa ggt tta gga aca aac acc 32606 Lys Thr Leu Val Val Ala Tyr Gly Gln Gly Leu Gly Thr Asn Thr 6005 6010 6015 act ggt gcc ctt gtt gcc caa cta gca tcc cca ctt gct ttt gat 32651 Thr Gly Ala Leu Val Ala Gln Leu Ala Ser Pro Leu Ala Phe Asp 6020 6025 6030 agc aat agc aaa att gcc ctt aat tta ggc aat gga cca ttg aaa 32696 Ser Asn Ser Lys Ile Ala Leu Asn Leu Gly Asn Gly Pro Leu Lys 6035 6040 6045 gtg gat gca aat aga ctg aac atc aat tgc aat aga gga ctc tat 32741 Val Asp Ala Asn Arg Leu Asn Ile Asn Cys Asn Arg Gly Leu Tyr 6050 6055 6060 gtt act acc aca aaa gat gca ctg gaa gcc aat ata agt tgg gct 32786 Val Thr Thr Thr Lys Asp Ala Leu Glu Ala Asn Ile Ser Trp Ala 6065 6070 6075 aat gct atg aca ttt ata gga aat gcc atg ggt gtc aat att gat 32831 Asn Ala Met Thr Phe Ile Gly Asn Ala Met Gly Val Asn Ile Asp 6080 6085 6090 aca caa aaa ggc ttg caa ttt ggc acc act agt acc gtc gca gat 32876 Thr Gln Lys Gly Leu Gln Phe Gly Thr Thr Ser Thr Val Ala Asp 6095 6100 6105 gtt aaa aac gct tac ccc ata caa atc aaa ctt gga gct ggt ctc 32921 Val Lys Asn Ala Tyr Pro Ile Gln Ile Lys Leu Gly Ala Gly Leu 6110 6115 6120 aca ttt gac agc aca ggt gca att gtt gca tgg aac aaa gat gat 32966 Thr Phe Asp Ser Thr Gly Ala Ile Val Ala Trp Asn Lys Asp Asp 6125 6130 6135 gac aag ctt aca cta tgg acc aca gcc gac ccc tct cca aat tgt 33011 Asp Lys Leu Thr Leu Trp Thr Thr Ala Asp Pro Ser Pro Asn Cys 6140 6145 6150 cac ata tat tct gaa aag gat gct aag ctt aca ctt tgc ttg aca 33056 His Ile Tyr Ser Glu Lys Asp Ala Lys Leu Thr Leu Cys Leu Thr 6155 6160 6165 aag tgt ggc agt cag att ctg ggc act gtt tcc ctc ata gct gtt 33101 Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Ser Leu Ile Ala Val 6170 6175 6180 gat act ggc agt tta aat ccc ata aca gga aca gta acc act gct 33146 Asp Thr Gly Ser Leu Asn Pro Ile Thr Gly Thr Val Thr Thr Ala 6185 6190 6195 ctt gtc tca ctt aaa ttc gat gca aat gga gtt ttg caa agc agc 33191 Leu Val Ser Leu Lys Phe Asp Ala Asn Gly Val Leu Gln Ser Ser 6200 6205 6210 tca aca cta gac tca gac tat tgg aat ttc aga cag gga gat gtt 33236 Ser Thr Leu Asp Ser Asp Tyr Trp Asn Phe Arg Gln Gly Asp Val 6215 6220 6225 aca cct gct gaa gcc tat act aat gct ata ggt ttc atg ccc aat 33281 Thr Pro Ala Glu Ala Tyr Thr Asn Ala Ile Gly Phe Met Pro Asn 6230 6235 6240 cta aaa gca tac cct aaa aac aca agt gga gct gca aaa agt cac 33326 Leu Lys Ala Tyr Pro Lys Asn Thr Ser Gly Ala Ala Lys Ser His 6245 6250 6255 att gtt ggg aaa gtg tac cta cat ggg gat aca gac aaa cca ctg 33371 Ile Val Gly Lys Val Tyr Leu His Gly Asp Thr Asp Lys Pro Leu 6260 6265 6270 gac ctc att att act ttc aat gaa aca agt gat gaa tct tgc act 33416 Asp Leu Ile Ile Thr Phe Asn Glu Thr Ser Asp Glu Ser Cys Thr 6275 6280 6285 tac tgt att aac ttt caa tgg cag tgg ggg gct gat caa tat aaa 33461 Tyr Cys Ile Asn Phe Gln Trp Gln Trp Gly Ala Asp Gln Tyr Lys 6290 6295 6300 aat gaa aca ctt gcc gtc agt tca ttc acc ttt tcc tat att gct 33506 Asn Glu Thr Leu Ala Val Ser Ser Phe Thr Phe Ser Tyr Ile Ala 6305 6310 6315 aaa gaa taaaccccac tctgtacccc atctctgtct atggaaaaaa ctctgaaaca 33562 Lys Glu caaaataaaa taaagttcaa gtgttttatt gattcaacag ttttacagga ttcgagcagt 33622 tatttttcct ccaccctccc aggacatgga atacaccacc ctctcccccc gcacagcctt 33682 gaacatctga atgccattgg tgatggacat gcttttggtc tccacgttcc acacagtttc 33742 agagcgagcc agtctcgggt cggtcaggga gatgaaaccc tccgggcact cccgcatctg 33802 cacctcacag ctcaacagct gaggattgtc ctcggtggtc gggatcacgg ttatctggaa 33862 gaagcagaag agcggcggtg ggaatcatag tccgcgaacg ggatcggccg gtggtgtcgc 33922 atcaggcccc gcagcagtcg ctgtcgccgc cgctccgtca agctgctgct cagggggtcc 33982 gggtccaggg actccctcag catgatgccc acggccctca gcatcagtcg tctggtgcgg 34042 cgggcgcagc agcgcatgcg gatctcgctc aggtcgctgc agtacgtgca acacaggacc 34102 accaggttgt tcaacagtcc atagttcaac acgctccagc cgaaactcat cgcgggaagg 34162 atgctaccca cgtggccgtc gtaccagatc ctcaggtaaa tcaagtggcg ccccctccag 34222 aacacgctgc ccatgtacat gatctccttg ggcatgtggc ggttcaccac ctcccggtac 34282 cacatcaccc tctggttgaa catgcagccc cggatgatcc tgcggaacca cagggccagc 34342 accgccccgc ccgccatgca gcgaagagac cccgggtccc gacaatggca atggaggacc 34402 caccgctcgt acccgtggat catctgggag ctgaacaagt ctatgttggc acagcacagg 34462 catatgctca tgcatctctt cagcactctc agctcctcgg gggtcaaaac catatcccag 34522 ggcacgggga actcttgcag gacagcgaac cccgcagaac agggcaatcc tcgcacataa 34582 cttacattgt gcatggacag ggtatcgcaa tcaggcagca ccgggtgatc ctccaccaga 34642 gaagcgcggg tctcggtctc ctcacagcgt ggtaaggggg ccggccgata cgggtgatgg 34702 cgggacgcgg ctgatcgtgt tcgcgaccgt gtcatgatgc agttgctttc ggacattttc 34762 gtacttgctg tagcagaacc tggtccgggc gctgcacacc gatcgccggc ggcggtcccg 34822 gcgcttggaa cgctcggtgt tgaagttgta aaacagccac tctctcagac cgtgcagcag 34882 atctagggcc tcaggagtga tgaagatccc atcatgcctg atggctctaa tcacatcgac 34942 caccgtggaa tgggccagac ccagccagat gatgcaattt tgttgggttt cggtgacggc 35002 gggggaggga agaacaggaa gaaccatgat taacttttaa tccaaacggt ctcggagcac 35062 ttcaaaatga agatcgcgga gatggcacct ctcgcccccg ctgtgttggt ggaaaataac 35122 agccaggtca aaggtgatac ggttctcgag atgttccacg gtggcttcca gcaaagcctc 35182 cacgcgcaca tccagaaaca agacaatagc gaaagcggga gggttctcta attcctcaat 35242 catcatgtta cactcctgca ccatccccag ataattttca tttttccagc cttgaatgat 35302 tcgaactagt tcctgaggta aatccaagcc agccatgata aagagctcgc gcagagcgcc 35362 ctccaccggc attcttaagc acaccctcat aattccaaga tattctgctc ctggttcacc 35422 tgcagcagat tgacaagcgg aatatcaaaa tctctgccgc gatccctaag ctcctccctc 35482 agcaataact gtaagtactc tttcatatcc tctccgaaat ttttagccat aggaccgcca 35542 ggaatgagat taggacaagc cacattacag ataaaccgaa gtccccccca gtgagcattg 35602 ccaaatgtaa gattgaaata agcatgctgg ctagacccgg tgatatcttc cagataactg 35662 gacagaaaat cgcccaggca atttttaaga aaatcaacaa aagaaaaatc ttccaggtgc 35722 acgtttaggg cctcgggaac aacgatggag taagtgcaag gggtgcgttc cagcatggtt 35782 agttagctga tctgtaaaaa aacaaaaaat aaaacattaa accatgctag cctggcgaac 35842 aggtgggtaa atcgttctct ccagcaccag gcaggccacg gggtctccgg cgcgaccctc 35902 gtaaaaattg tcgctatgat tgaaaaccat cacagagaga cgttcccggt ggccggcgtg 35962 aatgattcga caagatgaat acacccccgg aacattggcg tccgcgagtg aaaaaaagcg 36022 gccgaggaag caataaggca ctacaatgct cagtctcaag tccagcaaag cgatgccatg 36082 cggatgaagc acaaaattct caggtgcgta caaaatgtaa ttactcccct cctgcacagg 36142 cagcaaagcc ccagatccct ccagatacac atacaaagcc tcagcgtcca tagcttaccg 36202 agcagcagca cacaacaggc gcaagagtca gagaaaggct gagctctaac ctgtcccccg 36262 ctctctgctc aatatatagc ccagatctac actgacgtaa aggccaaagt ctaaaaatac 36322 ccgccaaata atcacacacg cccagcacac gcccagaaac cggtgacaca ctcaaaaaaa 36382 tacgcgcact tcctcaaacg cccaaactgc cgtcatttcc gggttcccac gctacgtcat 36442 cagaattcga ctttcaaatc cgtcgaccgt taaacacgtc actcgccccg cccctaacgg 36502 tcgccctcct ctcggccaat cacagccccg catccccaaa ttcaaacgcc tcatttgcat 36562 attaacgcgc acaaaaagtt tgaggtatat tattgatgat g 36603 <210> 26 <211> 192 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 26 Met Glu Ile Trp Thr Val Leu Glu Asp Phe His Gln Thr Arg Gln Leu 1 5 10 15 Leu Glu Asn Ser Ser Glu Gly Val Ser Tyr Leu Trp Arg Phe Cys Phe 20 25 30 Gly Gly Pro Leu Ala Lys Leu Val Tyr Arg Ala Lys Gln Asp Tyr Lys 35 40 45 Asp Gln Phe Glu Asp Ile Leu Arg Glu Cys Pro Asp Ile Phe Asp Ser 50 55 60 Leu Asn Leu Gly His Gln Ser His Phe Asn Gln Ser Ile Leu Arg Ala 65 70 75 80 Leu Asp Phe Ser Thr Pro Gly Arg Thr Thr Ala Ala Val Ala Phe Phe 85 90 95 Ala Phe Ile Leu Asp Lys Trp Ser Gln Glu Thr His Phe Ser Arg Asp 100 105 110 Tyr Arg Leu Asp Cys Leu Ala Val Ala Leu Trp Arg Thr Trp Arg Cys 115 120 125 Gln Arg Leu Asn Ala Ile Ser Gly Tyr Leu Pro Val Gln Pro Val Asp 130 135 140 Thr Leu Arg Ile Leu Ser Leu Gln Ser Pro Gln Glu His Gln Arg Arg 145 150 155 160 Gln Gln Pro Gln Gln Glu Gln Gln Gln Glu Glu Glu Glu Asp Arg Glu 165 170 175 Glu Asn Pro Arg Ala Gly Leu Asp Pro Pro Val Ala Glu Glu Glu Glu 180 185 190 <210> 27 <211> 391 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 27 Met His Pro Val Leu Arg Gln Met Arg Pro His Pro Pro Pro Gln Pro 1 5 10 15 Pro Leu Pro Pro Gln Gln Gln Gln Gln Pro Ala Leu Leu Pro Pro Pro 20 25 30 Gln Gln Gln Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala Gly 35 40 45 Val Gln Tyr Asp Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala Arg Leu 50 55 60 Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys Arg Asp 65 70 75 80 Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp Arg Ser 85 90 95 Gly Glu Glu Pro Glu Glu Met Arg Ala Ser Arg Phe His Ala Gly Arg 100 105 110 Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp Glu Asp 115 120 125 Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala His Val 130 135 140 Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys Glu Glu 145 150 155 160 Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu Ile Ala 165 170 175 Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu Leu Glu 180 185 190 Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln Leu Phe 195 200 205 Leu Val Val Gln His Ser Arg Asp Asn Glu Thr Phe Arg Glu Ala Leu 210 215 220 Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu Val Asn 225 230 235 240 Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu Ser Glu 245 250 255 Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys Tyr Tyr 260 265 270 Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys Glu Val 275 280 285 Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu Thr Leu 290 295 300 Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg Ala Val 305 310 315 320 Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met His Ser 325 330 335 Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser Tyr Phe 340 345 350 Asp Met Gly Ala Asp Leu Arg Trp Gln Pro Ser Arg Arg Ala Leu Glu 355 360 365 Ala Ala Gly Gly Val Pro Tyr Val Glu Glu Val Asp Asp Asp Glu Glu 370 375 380 Glu Gly Glu Tyr Leu Glu Asp 385 390 <210> 28 <211> 587 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 28 Met Gln Gln Gln Pro Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu 1 5 10 15 Gln Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala 20 25 30 Met Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg 35 40 45 Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val 50 55 60 Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn 65 70 75 80 Ala Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val 85 90 95 Tyr Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val 100 105 110 Gln Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ser 115 120 125 Gln Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala 130 135 140 Leu Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln 145 150 155 160 Glu Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Ala Glu 165 170 175 Val Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln 180 185 190 Thr Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys 195 200 205 Asn Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala 210 215 220 Thr Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu 225 230 235 240 Val Ala Pro Phe Thr Asp Ser Gly Ser Val Ser Arg Asp Ser Tyr Leu 245 250 255 Gly Tyr Leu Leu Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val 260 265 270 Asp Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly 275 280 285 Gln Glu Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr 290 295 300 Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu 305 310 315 320 Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met 325 330 335 Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn 340 345 350 Met Glu Pro Ser Met Tyr Ala Arg Asn Arg Pro Phe Ile Asn Lys Leu 355 360 365 Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr 370 375 380 Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr 385 390 395 400 Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp 405 410 415 Val Asp Ser Ser Val Phe Ser Pro Arg Pro Thr Thr Thr Val Trp Lys 420 425 430 Lys Glu Gly Gly Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly Arg Ala 435 440 445 Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu 450 455 460 Pro Phe Ser Leu Asn Ser Val Arg Ser Ser Glu Leu Gly Arg Leu Thr 465 470 475 480 Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu 485 490 495 Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu 500 505 510 Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala His Glu His Arg Asp 515 520 525 Glu Pro Arg Ala Ser Ser Ser Ala Gly Ala Thr Arg Arg Arg Gln Arg 530 535 540 His Asp Arg Gln Arg Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp 545 550 555 560 Asp Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe 565 570 575 Ala His Leu Arg Pro Arg Ile Gly Arg Leu Met 580 585 <210> 29 <211> 542 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 29 Met Met Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Val Ala Ala Ala Met Gln Pro Pro Leu Glu Ala 20 25 30 Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg Asn Ser 35 40 45 Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg Leu Tyr 50 55 60 Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr Gln Asn 65 70 75 80 Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp Phe Thr 85 90 95 Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg 100 105 110 Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro Asn Val 115 120 125 Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser 130 135 140 Arg Lys Thr Pro Asn Gly Val Thr Val Asp Glu Asn Tyr Asp Gly Ser 145 150 155 160 Gln Asp Glu Leu Thr Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly 165 170 175 Asn Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile 180 185 190 Asp Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp 195 200 205 Ile Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro 210 215 220 Val Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His 225 230 235 240 Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser 245 250 255 Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu 260 265 270 Gly Phe Gln Ile Leu Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala 275 280 285 Leu Leu Asp Val Glu Ala Tyr Glu Lys Ser Lys Glu Glu Ala Ala Ala 290 295 300 Ala Ala Thr Ala Ala Val Ala Thr Ala Ala Thr Thr Asp Ala Asp Ala 305 310 315 320 Ala Thr Thr Thr Arg Gly Asp Thr Phe Ala Thr Gln Ala Glu Glu Ala 325 330 335 Ala Ala Leu Ala Ala Thr Asp Asp Ser Glu Ser Lys Ile Val Ile Lys 340 345 350 Pro Val Glu Lys Asp Ser Lys Asp Arg Ser Tyr Asn Val Leu Ser Asp 355 360 365 Gly Lys Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly 370 375 380 Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp 385 390 395 400 Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met 405 410 415 Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn Tyr Pro 420 425 430 Val Val Gly Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser Phe Phe Asn 435 440 445 Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Ala Phe Thr Ser Leu Thr 450 455 460 His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Val Arg Pro Pro 465 470 475 480 Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp 485 490 495 His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val 500 505 510 Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala 515 520 525 Leu Gly Val Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 530 535 540 <210> 30 <211> 194 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 30 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Ala Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ser 130 135 140 Ser Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala 145 150 155 160 Ala Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val 165 170 175 Arg Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro 180 185 190 Arg Thr <210> 31 <211> 348 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 31 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys Glu Glu Arg Lys Pro Arg 20 25 30 Lys Leu Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Glu Asp Asp Gly 35 40 45 Leu Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp 50 55 60 Arg Gly Arg Lys Val Lys Pro Val Leu Arg Pro Gly Thr Thr Val Val 65 70 75 80 Phe Thr Pro Gly Glu Arg Ser Gly Ser Ala Ser Lys Arg Ser Tyr Asp 85 90 95 Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu 100 105 110 Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Pro Ala Pro Leu Lys Glu 115 120 125 Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu 130 135 140 Lys Pro Val Thr Leu Gln Gln Val Leu Pro Ser Ala Ala Pro Arg Arg 145 150 155 160 Gly Phe Lys Arg Glu Gly Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu 165 170 175 Met Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu His Met Lys 180 185 190 Val Asp Pro Glu Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln 195 200 205 Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr 210 215 220 Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr 225 230 235 240 Met Glu Val Gln Thr Asp Pro Trp Met Pro Ala Pro Ala Ser Thr Thr 245 250 255 Thr Thr Thr Arg Arg Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met 260 265 270 Pro Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg 275 280 285 Gly Thr Arg Phe Tyr Arg Gly Tyr Ser Ser Arg Arg Lys Thr Thr Thr 290 295 300 Arg Arg Arg Arg Arg Arg Thr Arg Arg Ser Thr Thr Ala Thr Ser Ala 305 310 315 320 Ala Ala Leu Val Arg Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu Thr 325 330 335 Leu Pro Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 340 345 <210> 32 <211> 77 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 32 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly Asn Gly Leu Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 33 <211> 244 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 33 Met Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg 1 5 10 15 Pro Phe Met Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly 20 25 30 Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly 35 40 45 Ser Thr Leu Lys Thr Tyr Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly 50 55 60 Gln Ala Leu Arg Asp Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val 65 70 75 80 Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn 85 90 95 Gln Ala Val Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro 100 105 110 Ala Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu 115 120 125 Asp Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu 130 135 140 Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu 145 150 155 160 Gly Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu 165 170 175 Lys Pro Glu Ser Asn Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Gln 180 185 190 Pro Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val 195 200 205 Ala Arg Ala Arg Pro Gly Gly Ser Ala Arg Pro His Ala Asn Trp Gln 210 215 220 Ser Thr Leu Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg 225 230 235 240 Arg Arg Cys Tyr <210> 34 <211> 943 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 34 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Ser Ser Gln Trp Glu Arg Ala Lys Thr Asn Asn Asn Gly 130 135 140 Ala Thr Glu Ser Val Thr Phe Gly Val Ala Ala Met Gly Gly Ile Asp 145 150 155 160 Ile Thr Lys Glu Gly Leu Gln Ile Gly Thr Asp Glu Thr Lys Ala Asp 165 170 175 Ser Lys Glu Ile Tyr Ala Asp Lys Thr Tyr Gln Pro Glu Pro Gln Ile 180 185 190 Gly Glu Glu Asn Trp Gln Glu Thr Phe Ser Tyr Tyr Gly Gly Arg Ala 195 200 205 Leu Lys Lys Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys 210 215 220 Pro Thr Asn Val Lys Gly Gly Gln Ala Lys Phe Lys Val Gln Asp Gly 225 230 235 240 Gln Gln Thr Thr Glu Tyr Asp Ile Asp Leu Ala Phe Phe Asp Ile Pro 245 250 255 Asn Ser Gly Thr Gly Gly Asn Gly Thr Asn Val Asn Tyr Asp Pro Asp 260 265 270 Met Val Met Tyr Thr Glu Asn Val Asp Leu Glu Thr Pro Asp Thr His 275 280 285 Ile Val Tyr Lys Pro Gly Thr Ser Asp Asp Ser Ser Glu Ala Asn Leu 290 295 300 Leu Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp 305 310 315 320 Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val 325 330 335 Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp 340 345 350 Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp 355 360 365 Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp 370 375 380 Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro 385 390 395 400 Asn Tyr Cys Phe Pro Leu Asp Gly Ala Gly Thr Asn Ala Val Tyr Gln 405 410 415 Gly Val Lys Ala Lys Thr Asn Gly Gly Ala Ala Asn Gly Asp Trp Glu 420 425 430 Gln Asp Thr Asp Val Ser Asn Ile Asn Gln Ile Cys Lys Gly Asn Ile 435 440 445 Tyr Ala Met Glu Ile Asn Leu Gln Ala Asn Leu Trp Arg Ser Phe Leu 450 455 460 Tyr Ser Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr Pro 465 470 475 480 Ala Asn Ile Thr Leu Pro Thr Asn Thr Asn Thr Tyr Asp Tyr Met Asn 485 490 495 Gly Arg Val Ala Pro Pro Ser Leu Val Asp Ala Tyr Ile Asn Ile Gly 500 505 510 Ala Arg Trp Ser Leu Asp Pro Met Asp Asn Val Asn Pro Phe Asn His 515 520 525 His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly 530 535 540 Arg Phe Val Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile 545 550 555 560 Lys Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe 565 570 575 Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu 580 585 590 Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala 595 600 605 Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met 610 615 620 Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala 625 630 635 640 Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Val Pro Ile 645 650 655 Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr 660 665 670 Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro 675 680 685 Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr 690 695 700 Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe Asp Ser Ser Val 705 710 715 720 Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile 725 730 735 Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met 740 745 750 Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly 755 760 765 Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser 770 775 780 Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Val 785 790 795 800 Asn Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn Asn 805 810 815 Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln Pro 820 825 830 Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val Thr 835 840 845 Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met Trp Arg Ile 850 855 860 Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly 865 870 875 880 Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Asn Phe 885 890 895 Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr Val Val Phe Glu 900 905 910 Val Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu 915 920 925 Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 930 935 940 <210> 35 <211> 208 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 35 Met Ala Glu Pro Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile 1 5 10 15 Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg 20 25 30 Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn 35 40 45 Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp 50 55 60 Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser 65 70 75 80 Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu Leu 85 90 95 Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu Lys 100 105 110 Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu Phe 115 120 125 Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro Met 130 135 140 Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly Met 145 150 155 160 Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu Ala 165 170 175 Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe Arg Ser His Arg 180 185 190 Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Gln Asp Met 195 200 205 <210> 36 <211> 798 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 36 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ala 1 5 10 15 Ala Asp Glu Asn Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro 20 25 30 Pro Ser Pro Thr Ser Asp Ala Ala Ala Pro Asp Met Gln Glu Met Glu 35 40 45 Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu 50 55 60 Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln Glu 65 70 75 80 Gln Pro Glu Gln Glu Ala Glu Ser Glu Gln Ser Gln Ala Gly Leu Glu 85 90 95 His Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu Ile Lys His Leu 100 105 110 Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Ala Glu 115 120 125 Val Pro Leu Ser Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg Asn Leu 130 135 140 Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys Glu 145 150 155 160 Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu Ala 165 170 175 Leu Ala Thr Tyr His Leu Phe Phe Lys Asn Gln Arg Ile Pro Val Ser 180 185 190 Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Leu Asn Leu Gly Pro 195 200 205 Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro Lys Ile 210 215 220 Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu Gln 225 230 235 240 Gly Ser Gly Glu Glu His Glu His His Ser Ala Leu Val Glu Leu Glu 245 250 255 Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu Thr 260 265 270 His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser Ala 275 280 285 Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu Glu 290 295 300 Glu Met Gln Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val Val Ser 305 310 315 320 Asp Glu Gln Leu Ala Arg Trp Leu Gly Thr Ser Ser Thr Pro Gln Ser 325 330 335 Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr Val 340 345 350 Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu Arg 355 360 365 Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val Arg 370 375 380 Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr 385 390 395 400 Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr 405 410 415 Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr 420 425 430 Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln Gln 435 440 445 Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys 450 455 460 Asn Leu Lys Ala Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser 465 470 475 480 Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg 485 490 495 Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg 500 505 510 Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala 515 520 525 Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro 530 535 540 Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala Tyr 545 550 555 560 His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu Cys 565 570 575 His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys Asn 580 585 590 Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln 595 600 605 Gly Pro Gly Glu Glu Gly Lys Gly Gly Leu Lys Leu Thr Pro Gly Leu 610 615 620 Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr His Pro 625 630 635 640 Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys Ala Glu 645 650 655 Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala Gln Leu Gln 660 665 670 Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly His Gly 675 680 685 Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro Ser Phe Pro 690 695 700 Gln Asp Ala Gln Arg Lys Gln Gln Glu Ala Glu Ser Gly Ala Ala Ala 705 710 715 720 Ala Ala Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly 725 730 735 Gly Gly Asp Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln Pro 740 745 750 Ala Arg Gln Ser Gly Arg Arg Gly Gly Gly Gly Arg Gly Arg Ser Ser 755 760 765 Arg Arg Gln Thr Val Val Leu Gly Gly Glu Ser Lys Gln His Gly Tyr 770 775 780 His Leu Arg Ser Gly Ser Gly Ser Arg Arg Pro Gly Pro Gln 785 790 795 <210> 37 <211> 227 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 37 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr 50 55 60 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 38 <211> 106 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 38 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Ala 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Ile Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Arg Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asn His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 39 <211> 176 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 39 Met Gly Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val Val 1 5 10 15 Leu Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu Lys Ala 20 25 30 Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Thr Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Ala His Met Cys Asp Thr Val Met Trp Met Ser Lys Gln Tyr Asp Met 115 120 125 Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Leu Cys Thr Val Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 40 <211> 200 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 40 Met Ala Ser Val Lys Phe Leu Leu Leu Phe Ala Ser Leu Ile Thr Val 1 5 10 15 Ile Ser Asn Glu Lys Leu Thr Ile Tyr Ile Gly Thr Asn His Thr Leu 20 25 30 Glu Gly Ile Pro Lys Ser Ser Trp Tyr Cys Tyr Phe Asp Gln Asp Pro 35 40 45 Asp Leu Thr Ile Glu Leu Cys Gly Asn Lys Gly Gln Asn Thr Ser Ile 50 55 60 His Leu Ile Asn Phe Lys Cys Gly Asp Asp Leu Lys Leu Ile Asn Ile 65 70 75 80 Thr Lys Glu Tyr Gly Gly Met Tyr Tyr Tyr Val Thr Glu Asn Asn Asn 85 90 95 Met Gln Phe Tyr Glu Val Thr Val Thr Asn Pro Thr Thr Pro Arg Thr 100 105 110 Thr Thr Thr Thr Thr Lys Thr Thr Pro Val Thr Thr Met Gln Leu Thr 115 120 125 Thr Asn Asn Ile Phe Ala Met Arg Gln Lys Ala Asn Asn Ser Thr Ser 130 135 140 Ile Gln Pro Pro Pro Pro Ser Glu Glu Ile Pro Lys Ser Met Ile Gly 145 150 155 160 Ile Ile Val Ala Val Val Val Cys Met Leu Ile Ile Ala Leu Cys Met 165 170 175 Val Tyr Tyr Ala Phe Cys Tyr Arg Lys His Arg Leu Asn Asp Lys Leu 180 185 190 Glu His Leu Leu Ser Val Glu Phe 195 200 <210> 41 <211> 204 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 41 Met Lys Ile Leu Gly Leu Leu Ile Phe Ser Ile Ile Thr Ser Ala Leu 1 5 10 15 Cys Asn Ser Asp Asn Glu Asp Val Thr Val Val Val Gly Ser Asn Tyr 20 25 30 Thr Leu Lys Gly Pro Ala Lys Gly Met Leu Ser Trp Tyr Cys Trp Phe 35 40 45 Gly Thr Asp Thr Glu Gln Thr Glu Leu Cys Asn Leu Gln Asn Gly Lys 50 55 60 Val His Asn Ser Lys Ile Tyr Asn Tyr Ile Cys Asn Gly Thr Asp Leu 65 70 75 80 Ile Leu Leu Asn Ile Thr Lys Ser Tyr Ala Gly Ser Tyr Ser Cys Pro 85 90 95 Gly Asp Asp Ala Asp Asn Met Ile Phe Tyr Lys Leu Gln Val Val Asp 100 105 110 Pro Thr Thr Pro Pro Pro Pro Thr Thr Thr Thr His Thr Thr His Thr 115 120 125 Glu Gln Thr Thr Ala Glu Glu Ala Ala Lys Leu Ala Leu Gln Val Gln 130 135 140 Asp Ser Ser Phe Val Gly Ile Thr Pro Thr Pro Asp Gln Arg Cys Pro 145 150 155 160 Gly Leu Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly Leu Ala Val 165 170 175 Ile Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr 180 185 190 Arg Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 195 200 <210> 42 <211> 292 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 42 Met Lys Ala Val Ser Ala Leu Val Phe Cys Ser Leu Ile Gly Thr Val 1 5 10 15 Phe Ser Val Ser Phe Leu Lys Gln Ile Asn Val Thr Glu Gly Glu Asn 20 25 30 Val Thr Leu Val Gly Val Glu Gly Ala Gln Asn Thr Thr Trp Thr Lys 35 40 45 Tyr His Leu Asp Gly Trp Lys Asp Ile Cys Asn Trp Ser Val Ile Thr 50 55 60 Tyr Thr Cys Glu Gly Val Asn Leu Thr Ile Val Asn Ala Ser Gln Asn 65 70 75 80 Gln Lys Gly Trp Ile Lys Gly Gln Ser Val Ser Val Thr Ser Glu Gly 85 90 95 Tyr Tyr Thr Gln His Thr Leu Ile Tyr Asp Ile Ile Val Ile Pro Leu 100 105 110 Pro Thr Pro Ser Pro Pro Ser Thr Thr Thr Gln Thr Thr His Thr Thr 115 120 125 Gln Thr Thr Thr Tyr Ser Thr Ser Asn Gln Pro Thr Thr Thr Thr Thr 130 135 140 Ala Glu Val Ala Ser Ser Ser Gly Val Arg Ala Ala Phe Leu Met Leu 145 150 155 160 Ala Pro Ser Ser Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Glu 165 170 175 Phe Leu Ser Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe 180 185 190 Ser Ser Thr Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro 195 200 205 Ala Thr Thr Thr Thr Pro Ala Ile Leu Pro Thr Pro Leu Lys Gln Thr 210 215 220 Glu Asp Ser Gly Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly 225 230 235 240 Leu Val Ile Leu Ala Val Leu Leu Tyr Tyr Ile Phe Arg Arg Arg Ile 245 250 255 Pro Asn Ala His Arg Lys Pro Val Tyr Lys Pro Ile Ile Val Gly Gln 260 265 270 Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser 275 280 285 Phe Thr Val Trp 290 <210> 43 <211> 143 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 43 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu Val Leu Pro Arg 1 5 10 15 Pro Val Asp Pro Arg Pro Pro Thr Gln Ser Pro Glu Glu Val Arg Lys 20 25 30 Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys 35 40 45 Ser Asp Met His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile 50 55 60 Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Cys Phe Asp Phe 65 70 75 80 Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr 85 90 95 Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Pro Gln Pro Arg 100 105 110 Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg Pro 115 120 125 Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 130 135 140 <210> 44 <211> 445 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 44 Met Ser Lys Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro Val Tyr 1 5 10 15 Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro 20 25 30 Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser 35 40 45 Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu 50 55 60 Lys Leu Gly Asp Gly Val Asp Leu Asp Ser Ser Gly Lys Leu Ile Ser 65 70 75 80 Asn Thr Ala Thr Lys Ala Ala Ala Pro Leu Ser Phe Ser Asn Asn Thr 85 90 95 Ile Ser Leu Asn Met Asp Thr Pro Phe Tyr Asn Asn Asn Gly Lys Leu 100 105 110 Gly Met Lys Val Thr Ala Pro Leu Lys Ile Leu Asp Thr Asp Leu Leu 115 120 125 Lys Thr Leu Val Val Ala Tyr Gly Gln Gly Leu Gly Thr Asn Thr Thr 130 135 140 Gly Ala Leu Val Ala Gln Leu Ala Ser Pro Leu Ala Phe Asp Ser Asn 145 150 155 160 Ser Lys Ile Ala Leu Asn Leu Gly Asn Gly Pro Leu Lys Val Asp Ala 165 170 175 Asn Arg Leu Asn Ile Asn Cys Asn Arg Gly Leu Tyr Val Thr Thr Thr 180 185 190 Lys Asp Ala Leu Glu Ala Asn Ile Ser Trp Ala Asn Ala Met Thr Phe 195 200 205 Ile Gly Asn Ala Met Gly Val Asn Ile Asp Thr Gln Lys Gly Leu Gln 210 215 220 Phe Gly Thr Thr Ser Thr Val Ala Asp Val Lys Asn Ala Tyr Pro Ile 225 230 235 240 Gln Ile Lys Leu Gly Ala Gly Leu Thr Phe Asp Ser Thr Gly Ala Ile 245 250 255 Val Ala Trp Asn Lys Asp Asp Asp Lys Leu Thr Leu Trp Thr Thr Ala 260 265 270 Asp Pro Ser Pro Asn Cys His Ile Tyr Ser Glu Lys Asp Ala Lys Leu 275 280 285 Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Ser 290 295 300 Leu Ile Ala Val Asp Thr Gly Ser Leu Asn Pro Ile Thr Gly Thr Val 305 310 315 320 Thr Thr Ala Leu Val Ser Leu Lys Phe Asp Ala Asn Gly Val Leu Gln 325 330 335 Ser Ser Ser Thr Leu Asp Ser Asp Tyr Trp Asn Phe Arg Gln Gly Asp 340 345 350 Val Thr Pro Ala Glu Ala Tyr Thr Asn Ala Ile Gly Phe Met Pro Asn 355 360 365 Leu Lys Ala Tyr Pro Lys Asn Thr Ser Gly Ala Ala Lys Ser His Ile 370 375 380 Val Gly Lys Val Tyr Leu His Gly Asp Thr Asp Lys Pro Leu Asp Leu 385 390 395 400 Ile Ile Thr Phe Asn Glu Thr Ser Asp Glu Ser Cys Thr Tyr Cys Ile 405 410 415 Asn Phe Gln Trp Gln Trp Gly Ala Asp Gln Tyr Lys Asn Glu Thr Leu 420 425 430 Ala Val Ser Ser Phe Thr Phe Ser Tyr Ile Ala Lys Glu 435 440 445 <210> 45 <211> 31900 <212> DNA <213> Unknown <220> <223> Simian adenovirus A1320 <220> <221> CDS <222> (1904)..(3415) <223> E1b\55K <220> <221> CDS <222> (25615)..(26169) <223> 22K <220> <221> CDS <222> (27476)..(28096) <223> E3\CR1-alpha <220> <221> CDS <222> (31477)..(31881) <223> E3\14.7K <400> 45 catcatcaat aatatacctc aaactttttg tgcgcgttaa tatgcaaatg aggcgtttga 60 atttggggat gcggggcggt gattggctgt gggaaaggcg accgttaggg gcggggcggg 120 tgacgttttg atgacgtgtt tgtgaggcgg agccggtttg caagttctcg tgggaaaagt 180 gacgtcaaac gaggtgtggt ttgaacacgg aaatactcaa ttttcccgcg ctctctgaca 240 ggaaatgagg tgtttctggg cggatgcaag tgaaaacggg ccattttcgc gcgaaaactg 300 aatgaggaag tgaaaatctg agtaatttcg cgtttatggc agggaggagt atttgccgag 360 ggccgagtag actttgaccg attacgtggg ggtttcgatt accgtgtttt tcacctaaat 420 ttccgcgtac ggtgtcaaag tccggtgttt ttacgtaggt gtcagctgat cgccagggta 480 tttaaacctg cgctctccag tcaagaggcc actcttgagt gccagcgaga agagttttct 540 cctccgcgcc gcgagtcaga tctacacttt gaaagatgag gcacctgaga gacctgcccg 600 gtaatgtttt cctggctact gggaacgaga ttctggaact ggtggtggac gccatgatgg 660 gtgacgaccc tcctgagccc cctaccccat ttgaggcgcc ttcgctgtac gatttgtatg 720 atctggaggt ggatgtgccc gagaacgacc ccaacgagga ggcggtgaat gatttgttta 780 gcgatgccgc gctgctggcc gccgagcagg ctaatacgga ctctggctca gacagcgatt 840 cctctctcca taccacgaga cccggcagag gtgagaaaaa gatccccgag cttaaagggg 900 aagagctcga cctgcgctgc tatgaggaat gcttgcctcc gagcgatgat gaggaggacg 960 aggaggcgat tcgagctgca gcgagcgagg gagtgaaagc tgcgggcgag agctttagcc 1020 tggactgtcc tactctgccc ggacacggct gtaagtcttg tgaatttcat cgcatgaata 1080 ctggagataa gaatgtgatg tgtgccctgt gctatatgag agcttacaac cattgtgttt 1140 acagtaagtg tgattaactt tagctgggaa ggcagagggt gactgggtgc tgactggttt 1200 atttatgtat gtattcttta tgtgtaggtc ccgtctctga cgtagatgag acccccactt 1260 cagagtgcat ttcatcaccc ccagaaattg gcgaggaacc gcccgaagat attattcata 1320 gaccagttgc agtgagagtc accgggcgga gagcagctgt ggagagtttg gatgacttgc 1380 tacagggtgg ggatgaacct ttggacttgt gtacccggaa acgccccagg cactaagtgc 1440 cacacatgtg tgtttactta aggtgatgtc agtatttata gggtgtggag tgcaataaaa 1500 tccgtgttga ctttaagtgc gtggtttatg actcaggggt ggggactgtg ggtatataag 1560 caggtgcaga cctgtgtggt cagttcagag caggactcat ggagatctgg acggtcttgg 1620 aagactttca ccagactaga cagctgctag agaactcatc ggagggagtc tcttacctgt 1680 ggagattctg cttcggtggg cctctagcta agctagtcta tagggccaaa caggattata 1740 aggatcaatt tgaggatatt ttgagagagt gtcctgatat ttttgactct ctcaacttgg 1800 gccatcagtc tcactttaac cagagtattc tgagagccct tgacttttct actcctggca 1860 gaactaccgc cgcggtagcc ttttttgcct ttatccttga caa atg gag tca aga 1915 Met Glu Ser Arg 1 aac cca ttt cag cag gga tta ccg tct gga ctg ctt agc agt agc ttt 1963 Asn Pro Phe Gln Gln Gly Leu Pro Ser Gly Leu Leu Ser Ser Ser Phe 5 10 15 20 gtg gag aac atg gag gtg cca gcg cct gaa tgc aat ctc cgg cta ctt 2011 Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn Leu Arg Leu Leu 25 30 35 gcc agt aca gcc ggt aga cac gct gag gat cct gag tct cca gtc acc 2059 Ala Ser Thr Ala Gly Arg His Ala Glu Asp Pro Glu Ser Pro Val Thr 40 45 50 cca gga aca cca acg ccg cca gca gcc gca gca gga gca gca gca aga 2107 Pro Gly Thr Pro Thr Pro Pro Ala Ala Ala Ala Gly Ala Ala Ala Arg 55 60 65 gga gga gga gga ccg aga aga gaa ccc gag agc cgg tct gga ccc tcc 2155 Gly Gly Gly Gly Pro Arg Arg Glu Pro Glu Ser Arg Ser Gly Pro Ser 70 75 80 ggt ggc gga gga gga gga gta gct gac ttg ttt ccc gag ctg cgc cgg 2203 Gly Gly Gly Gly Gly Gly Val Ala Asp Leu Phe Pro Glu Leu Arg Arg 85 90 95 100 gtg ctg act agg tct tcc agt gga cgg gag agg ggg att aag cgg gag 2251 Val Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly Ile Lys Arg Glu 105 110 115 agg cat gag gag act agt cac aga act gaa ctg act gtc agt ctg atg 2299 Arg His Glu Glu Thr Ser His Arg Thr Glu Leu Thr Val Ser Leu Met 120 125 130 agc cgc agg cgc cca gaa tcg gtg tgg tgg cat gag gtt cag tcg cag 2347 Ser Arg Arg Arg Pro Glu Ser Val Trp Trp His Glu Val Gln Ser Gln 135 140 145 ggg ata gat gag gtc tcg gta atg cat gag aaa tat tcc cta gaa caa 2395 Gly Ile Asp Glu Val Ser Val Met His Glu Lys Tyr Ser Leu Glu Gln 150 155 160 gtc aag act tgt tgg ttg gag ccc gag gat gat tgg gag gta gcc atc 2443 Val Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp Glu Val Ala Ile 165 170 175 180 agg aat tat gcc aag ttg gct ctg aag cca gac aag aag tac aag att 2491 Arg Asn Tyr Ala Lys Leu Ala Leu Lys Pro Asp Lys Lys Tyr Lys Ile 185 190 195 acc aag ttg att aat atc aga aat tcc tgc tac att tcg ggg aat ggg 2539 Thr Lys Leu Ile Asn Ile Arg Asn Ser Cys Tyr Ile Ser Gly Asn Gly 200 205 210 gcc gag gtg gag atc agt acc cag gag agg gtg gcc ttc aga tgc tgc 2587 Ala Glu Val Glu Ile Ser Thr Gln Glu Arg Val Ala Phe Arg Cys Cys 215 220 225 atg atg aat atg tac ccg ggg gtg gtg ggc atg gag gga gtt acc ttt 2635 Met Met Asn Met Tyr Pro Gly Val Val Gly Met Glu Gly Val Thr Phe 230 235 240 atg aac gcg agg ttt agg ggt gat ggg tat aat ggg gtg gtc ttt atg 2683 Met Asn Ala Arg Phe Arg Gly Asp Gly Tyr Asn Gly Val Val Phe Met 245 250 255 260 gcc aac acc aag ctg aca gtg cac gga tgc tcc ttc ttt ggc ttc aat 2731 Ala Asn Thr Lys Leu Thr Val His Gly Cys Ser Phe Phe Gly Phe Asn 265 270 275 aac atg tgc atc gag gcc tgg ggc agt gtt tca gtg agg gga tgc agc 2779 Asn Met Cys Ile Glu Ala Trp Gly Ser Val Ser Val Arg Gly Cys Ser 280 285 290 ttt tca gcc aac tgg atg ggg gtc gtg ggc aga acc aag agc aag gtg 2827 Phe Ser Ala Asn Trp Met Gly Val Val Gly Arg Thr Lys Ser Lys Val 295 300 305 tca gtg aag aaa tgc ctg ttc gag agg tgc cac ctg ggg gtg atg agc 2875 Ser Val Lys Lys Cys Leu Phe Glu Arg Cys His Leu Gly Val Met Ser 310 315 320 gag ggc gaa gcc aaa gtt aaa cac tgc gcc tct acc gag acg ggc tgc 2923 Glu Gly Glu Ala Lys Val Lys His Cys Ala Ser Thr Glu Thr Gly Cys 325 330 335 340 ttt gtg ctg atc aag ggc aat gcc caa gtc aag cat aac atg atc tgt 2971 Phe Val Leu Ile Lys Gly Asn Ala Gln Val Lys His Asn Met Ile Cys 345 350 355 ggg gcc tcg gat gag cgc ggc tac cag atg ctg acc tgc gcc ggt ggg 3019 Gly Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr Cys Ala Gly Gly 360 365 370 aac agc cat atg ctg gcc acc gtg cat gtg gcc tcg cac ccc cgc aag 3067 Asn Ser His Met Leu Ala Thr Val His Val Ala Ser His Pro Arg Lys 375 380 385 aca tgg ccc gag ttc gag cac aac gtc atg acc cgc tgc aat gtg cac 3115 Thr Trp Pro Glu Phe Glu His Asn Val Met Thr Arg Cys Asn Val His 390 395 400 ctg ggc tcc cgc cga ggc atg ttc atg cca tac cag tgc aac atg caa 3163 Leu Gly Ser Arg Arg Gly Met Phe Met Pro Tyr Gln Cys Asn Met Gln 405 410 415 420 ttt gtg aag gtg ctg ctg gag ccc gat gcc atg tcc aga gtg agc ctg 3211 Phe Val Lys Val Leu Leu Glu Pro Asp Ala Met Ser Arg Val Ser Leu 425 430 435 acg ggg gtg ttt gac atg aat gtg gag ctg tgg aaa att ctg aga tat 3259 Thr Gly Val Phe Asp Met Asn Val Glu Leu Trp Lys Ile Leu Arg Tyr 440 445 450 gat gaa tcc aag acc agg tgc cgg gcc tgc gaa tgc gga ggc aag cac 3307 Asp Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys Gly Gly Lys His 455 460 465 gcc agg ctt cag ccc gtg tgt gtg gag gtg acg gag gac ctg cga ccc 3355 Ala Arg Leu Gln Pro Val Cys Val Glu Val Thr Glu Asp Leu Arg Pro 470 475 480 gat cat ttg gtg ttg tcc tgc aac ggg acg gag ttc ggc tcc agc ggg 3403 Asp His Leu Val Leu Ser Cys Asn Gly Thr Glu Phe Gly Ser Ser Gly 485 490 495 500 gaa gaa tct gac tagagtgagt agtgtttggg ggtgggtggg agcctgcatg 3455 Glu Glu Ser Asp atgggcagaa tgactaaaat ctgtgttttt ctgcgcagca gcatgagcgg aagcgcctcc 3515 tttgagggag gggtattcag cccttatctg acggggcgtc tcccctcctg ggctggagtg 3575 cgtcagaatg tgatgggatc cacggtggac ggccggcccg tgcagcccgc gaactcttca 3635 accctgacct acgcgaccct gagctcctcg tccgtggacg cagctgccgc cgcagctgct 3695 gcttccgccg ccagcgccgt gcgcggaatg gccctgggtg ccggctacta cagctctctg 3755 gtggccaact cgagttccgc caataatccc gccagcctga acgaggagaa gctgctgctg 3815 ctgatggccc agctcgaggc cctgacccag cgcctgggcg agctgaccca gcaggtggct 3875 cagctgcagg cggagacgcg ggccgcggtt gccacggtga aaaccaaata aaaaatgaat 3935 caataaataa acggaaacgg ttgttgattt taacacagag tcttgaatct ttatttgatt 3995 tttcgcgcgc ggtaggccct ggaccaccgg tctcgatcat tgagcacccg gtggatcttt 4055 tccaggaccc ggtagaggtg ggcttggatg ttgaggtaca tgggcatgag cccgtcccgg 4115 gggtggaggt agctccactg cagggcctcg tgctcggggg tggtgttgta aatcacccag 4175 tcatagcagg ggcgcagggc gtggtgctgc acgatgtcct tgaggaggag actgatggcc 4235 acgggcagtc ccttggtgta ggtgttgacg aacctgttga gctgggaggg atgcatgcgg 4295 ggggagatga gatgcatctt ggcctggatc ttgagattgg cgatgttccc acccagatcc 4355 cgccgggggt tcatgttgtg caggaccacc agcacggtgt atccggtgca cttggggaat 4415 ttgtcatgca acttggaagg gaaggcgtga aagaatttgg agacgccctt gtgaccgccc 4475 aggttttcca tgcactcatc catgatgatg gcgatgggcc cgtgggcggc ggcctgggca 4535 aagacgtttc gggggtcgga cacatcgtag ttgtggtcct gggtgagctc gtcataggcc 4595 attttaatga atttggggcg gagggtgccc gactggggga caaaggtgcc ctcgatcccg 4655 ggggcgtagt tgccctcgca gatctgcatc tcccaggcct tgagctcgga gggggggatc 4715 atgtccacct gcggggcgat gaaaaaaacg gtttccgggg cgggggagat gagctgggcc 4775 gaaagcaggt tccggagcag ctgggacttg ccgcagccgg tggggccgta gatgaccccg 4835 atgaccggct gcaggtggta gttgagggag agacagctgc cgtcctcgcg gaggaggggg 4895 gccacctcgt tcatcatctc gcgcacatgc atgttctcgc gcacgagttc cgccaggagg 4955 cgctcgcccc ccagcgagag gagctcttgc agcgaggcga agtttttcag cggcttgagt 5015 ccgtcggcca tgggcatttt ggagagggtc tgttgcaaga gttccagacg gtcccagagc 5075 tcggtgatgt gctctagggc atctcgatcc agcagacctc ctcgtttcgc gggttggggc 5135 ggctgcggga gtagggcacc aggcgatggg cgtccagcga ggccagggtc cggtccttcc 5195 agggtcgcag ggtccgcgtc agcgtggtct ccgtcacggt gaaggggtgc gcgccgggct 5255 gggcgcttgc gagggtgcgc ttcaggctca tccggctggt cgagaaccgc tcccggtcgg 5315 tgccctgcgc gtcggccagg tagcaattga gcatgagttc gtagttgagc gcctcggccg 5375 cgtggccctt ggcgcggagc ttacctttgg aagtgtgtcc gcagacggga cagaggaggg 5435 acttgagggc gtagagcttg ggggcgagga agacggactc gggggcgtag gcgtccgcgc 5495 cgcagctggc gcagacggtc tcgcactcca cgagccaggt gaggtcgggg cggtcggggt 5555 caaaaacgag gtttcctccg tgctttttga tgcgtttctt acctctggtc tccatgagct 5615 cgtgtccccg ctgggtgaca aagaggctgt ccgtgtcccc gtagaccgac tttatgggcc 5675 ggtcctcgag cggggtgccg cggtcctcgt cgtagaggaa ccccgcccac tccgagacga 5735 aggcccgggt ccaggccagc acgaaggagg ccacgtggga ggggtagcgg tcgttgtcca 5795 ccagcgggtc caccttctcc agggtatgca agcacatgtc cccctcgtcc acatccagga 5855 aggtgattgg cttgtaagtg taggccacgt gaccgggggt cccggccggg ggggtataaa 5915 agggggcggg cccctgctcg tcctcactgt cttccggatc gctgtccagg agcgccagct 5975 gttggggtag gtattccctc tcgaaggcgg gcatgacctc ggcactcagg ttgtcagttt 6035 ctagaaacga ggaggatttg atattgacgg tgccgttgga gacgcctttc atgagcccct 6095 cgtccatctg gtcagaaaag acgatctttt tgttgtcgag cttggtggcg aaggagccgt 6155 agagggcatt ggagaggagc ttggcgatgg agcgcatggt ctggttcttt tccttgtcgg 6215 cgcgctcctt ggcggcgatg ttgagctgca cgtactcgcg cgccacgcac ttccattcgg 6275 ggaagacggt ggtgagctcg tcgggcacga ttctgacccg ccagccgcgg ttgtgcaggg 6335 tgatgaggtc cacgctggtg gccacctcgc cgcgcagggg ctcgttggtc cagcagaggc 6395 gcccgccctt gcgcgagcag aaggggggca gcgggtccag catgagctcg tcgggggggt 6455 cggcgtccac ggtgaagatg ccgggcagga gctcggggtc gaagtagctg atgcaggtgc 6515 ccagatcgtc cagcgccgct tgccagtcgc gcacggccag cgcgcgctcg taggggctga 6575 ggggcgtgcc ccagggcatg gggtgcgtga gcgcggaggc gtacatgccg cagatgtcgt 6635 agacgtagag gggctcctcg aggacgccga tgtaggtggg gtagcagcgc cccccgcgga 6695 tgctggcgcg cacgtagtcg tacagctcgt gcgagggcgc gaggagcccc gcgccgaggt 6755 tggagcgctg cggcttttcg gcgcggtaga cgatctggcg gaagatggcg tgggagttgg 6815 aggagatggt gggcctctgg aagatgttga agtgggcgtg gggcaggccg accgagtccc 6875 tgatgaagtg ggcgtaggag tcctgcagct tggcgacgag ctcggcggtg acgaggacgt 6935 ccagggcgca gtagtcgagg gtctcttgga tgatgtcgta cttgagctgg cccttctgct 6995 tccacagctc gcggttgaga aggaactctt cgcggtcctt ccagtactct tcgaggggga 7055 acccgtcctg atcggcacgg taagagccca ccatgtagaa ctggttgacg gccttgtagg 7115 cgcagcagcc cttctccacg gggagggcat aagcttgcgc ggccttgcgc agggaggtgt 7175 gggtgagggc gaaggtgtcg cgcaccatga ccttgaggaa ctggtgcttg aagtcgaggt 7235 cgtcgcagcc gccctgctcc cagagttgga agtccgtgcg cttcttgtag gcggggttgg 7295 gcaaagcgaa agtaacatcg ttgaagagga tcttgcccgc gcggggcatg aagttgcgag 7355 tgatgcggaa aggctggggc acctcggccc ggttgttgat gacctgggcg gcgaggacga 7415 tctcgtcgaa gccgttgatg ttgtgcccga cgatgtagag ttccacgaat cgcgggcggc 7475 ccttgacgtg gggcagcttc ttgagctcgt cgtaggtgag ctcggcgggg tcgctgagtc 7535 cgtgctgctc aagggcccag tcggcgacgt gggggttggc gctgaggaag gaagtccaga 7595 gatccacggc cagggcggtt tgcaagcggt cccggtactg acggaactgc tggcccacgg 7655 ccattttttc gggggtgatg cagtagaagg tgcgggggtc gccgtgccag cggtcccact 7715 tgagctggag ggcgaggtcg tgggcgagct cgacaagcgg cgggtccccg gagagtttca 7775 tgaccagcat gaaggggacg agctgcttgc cgaaggaccc catccaggtg taggtttcca 7835 catcgtaggt gaggaagagc ctttcggtgc gaggatgcga gccgatgggg aagaactgga 7895 tctcctgcca ccagttggag gaatggctgt tgatgtgatg gaagtagaaa tgccgacggc 7955 gcgccgagca ctcgtgcttg tgtttataca agcgtccgca gtgctcgcaa cgctgcacgg 8015 gatgcacgtg ctgcacgagc tgtacctgag ttcctttgac gaggaatttc agtgggcagt 8075 ggagcgctgg cggctgcatc tggtgctgta ctacgtcctg gccatcggcg tggccatcgt 8135 ctgcctcgat ggtggtcatg ctgacgagcc cgcgcgggag gcaggtccag acctcggctc 8195 ggacgggtcg gagagcgagg acgagggcgc gcaggccgga gctgtccagg gtcctgagac 8255 gctgcggagt caggtcagtg ggcagcggcg gcgcgcggtt gacttgcagg agcttttcca 8315 gggcgcgcgg gaggtccaga tggtacttga tctccacggc gccgttggtg gcgacgtcca 8375 cggcttgcag ggtcccgtgc ccctggggcg ccaccaccgt gccccgtttc ttcttgggcg 8435 ctggcggcgt tggcgctggt tccatgtcgg tcagaagcgg cggcgaggac gcgcgccggg 8495 cggcaggggc ggctcggggc ccggaggcag gggcggcagg ggcacgtcgg cgccgcgcgc 8555 gggcaggttc tggtactgcg cccggagaag actggcgtga gcgacgacgc gacggttgac 8615 gtcctggatc tgacgcctct gggtgaaggc cacgggaccc gtgagtttga acctgaaaga 8675 gagttcgaca gaatcaatct cggtatcgtt gacggcggcc tgccgcagga tctcttgcac 8735 gtcgcccgag ttgtcctggt aggcgatctc ggtcatgaac tgctcgatct cctcctcctg 8795 aaggtctccg cggccggcgc gctcgacggt ggccgcgagg tcgttggaga tgcgggccat 8855 gagctgcgag aaggcgttca tgccggcctc gttccagacg cggctgtaga ccacggctcc 8915 gtcggggtcg cgcgcgcgca tgaccacctg ggcaaggttg agctcgacgt ggcgcgtgaa 8975 gaccgcgtag ttgcagaggc gctggtagag gtagttgagc gtggtggcga tgtgctcggt 9035 gacgaagaag tacatgatcc agcggcggag cggcatctcg ctgacgtcgc ccagggcttc 9095 caagcgctcc atggcctcgt agaagtccac ggcgaagttg aaaaactggg agttgcgcgc 9155 cgagacggtc aactcctcct ccagaagacg gatgagctct gcgatggtgg cgcgcacctc 9215 gcgctcgaag gccccggggg gctcctcttc ttccatctcc tcctcctctt cctcctccac 9275 taacatctct tctacttcct cctcaggcgg tggtggcggg ggagggggcc tgcgtcgccg 9335 gcggcgcacg ggcagacggt cgatgaagcg ctcgatggtc tcgccgcgcc ggcgtcgcat 9395 ggtctcggtg acggcgcgcc cgtcctcgcg gggccgcagc gtgaagacgc cgccgcgcat 9455 ctccaggtgg ccgggggggt ccccgttggg cagggagagg gcgctgacga tgcatcttat 9515 caattgcccc gtagggactc cgcgcaagga cctgagcgtc tcgagatcca cgggatctga 9575 aaaccgttga acgaaggctt cgagccagtc gcagtcgcaa ggtaggctga gcacggtttc 9635 ttctggcggg tcatgttggt tggagggagc ggggcgggcg atgctgctgg tgatgaagtt 9695 gaaataggcg gttctgagac ggcggatggt ggcgaggagc accaggtctt tgggcccggc 9755 ttgctggatg cgcagacggt cggccatgcc ccaggcgtgg tcctgacacc tggccaggtc 9815 cttgtagtag tcctgcatga gccgctccac gggcacctcc tcctcgcccg cgcggccgtg 9875 catgcgcgtg agcccgaagc cgcgctgggg ctggacgagc gccaggtcgg cgacgacgcg 9935 ctcggcgagg atggcctgct ggacctgggt gagggtggtc tggaagtcgt cgaagtcgac 9995 gaagcggtgg taggctccgg tgttgatggt gtaggagcag ttggccatga cggaccagtt 10055 gacggtctgg tggccggggc gcacgagctc gtggtacttg aggcgcgagt aggcgcgcgt 10115 gtcgaagatg tagtcgttgc aggtgcgcac gaggtactgg tatccgacga ggaagtgcgg 10175 cggcggctgg cggtagagcg gccatcgctc ggtggcgggg gcgccgggcg cgaggtcctc 10235 gagcatgagg cggtggtagc cgtagatgta cctggacatc caggtgatgc cggcggcggt 10295 ggtggaggcg cgcgggaact cgcggacgcg gttccagatg ttgcgcagcg gcaggaagta 10355 gttcatggtg gccgcggtct ggcccgtgag gcgcgcgcag tcgtggatgc tctagacata 10415 cgggcaaaaa cgaaagcggt cagcggctcg actccgtggc ctggaggcta agcgaacggg 10475 ttgggctgcg cgtgtacccc ggttcgagtc tctgctcgaa tcaggctgga gccgcagcta 10535 acgtggtact ggcactcccg tctcgaccca agcctgctaa cgaaacctcc aggatacgga 10595 ggcgggtcgt tttttggcct tggtcactgg tcatgaaaaa ctagtaagcg cggaaagcgg 10655 ccgcccgcga tggctcgctg ccgtagtctg gagaaagaat cgccagggtt gcgttgcggt 10715 gtgccccggt tcgagactca gcgctcggcg ccggccggat tccgcggcta acgtgggcgt 10775 ggctgccccg tcgtttccaa gaccccttag ccagccgact tctccagtta cggagcgagc 10835 ccctcttttt cttgtgtttt tgccagatgc atcccgtact gcggcagatg cgcccccacc 10895 ctccaccaca accgccccta ccgccgcagc agcagcaaca gccggcgctt ctgcccccgc 10955 cccagcagca gccagccact accgcggcgg ccgccgtgag cggagccggc gttcagtatg 11015 acctggcctt ggaagagggc gaggggctgg cgcggctggg ggcgtcgtcg ccggagcggc 11075 acccgcgcgt gcagatgaaa agggacgctc gcgaggccta cgtgcccaag cagaacctgt 11135 tcagagacag gagcggcgag gagcccgagg agatgcgcgc ctcccgcttc cacgcggggc 11195 gggagctgcg gcgcggcctg gaccgaaagc gggtgctgag ggacgaggat ttcgaggcgg 11255 acgagctgac ggggatcagc cccgcgcgcg cgcacgtggc cgcggccaac ctggtcacgg 11315 cgtacgagca gaccgtgaag gaggagagca acttccaaaa atccttcaac aaccacgtgc 11375 gcacgctgat cgcgcgcgag gaggtgaccc tgggcctgat gcatctgtgg gacctgttgg 11435 aggccatcgt gcagaacccc acgagcaagc cgctgacggc gcagctgttt ctggtggtgc 11495 agcacagtcg ggacaacgag acgttcaggg aggcgctgct gaatatcacc gagcccgagg 11555 gccgctggct cctggacctg gtgaacattc tgcagagcat cgtggtgcag gagcgcgggc 11615 tgccgctgtc cgagaagctg gcggccatca acttctcggt gctgagcctg ggcaagtact 11675 acgctaggaa gatctacaag accccgtacg tgcccataga caaggaggtg aagatcgacg 11735 ggttttacat gcgcatgacc ctgaaagtgc tgaccctgag cgacgatctg ggggtgtacc 11795 gcaacgacag gatgcaccgc gcggtgagcg ccagccgccg gcgcgagctg agcgaccagg 11855 agctgatgca cagcctgcag cgggccctga ccggggccgg gaccgagggg gagagctact 11915 ttgacatggg cgcggacctg cgctggcagc ccagccgccg ggctttagag gcagccggcg 11975 gcgtgcccta cgtggaggag gtggacgatg atgaggagga gggcgagtac ctggaagact 12035 gatggcgcga ccgtattttt gctagatgca gcaacagcca ccgcctcctg atcccgcgat 12095 gcgggcggcg ctgcagagcc agccgtccgg cattaactcc tcggacgatt ggacccaggc 12155 catgcaacgc atcatggcgc tgacgacccg caatcccgaa gcctttagac agcagcctca 12215 ggccaaccgg ctctcggcca tcctggaggc cgtggtgccc tcgcgctcga accccacgca 12275 cgagaaggtg ctggccatcg tgaacgcgct ggtggagaac aaggccatcc gcggcgacga 12335 ggccgggctg gtgtacaacg cgctgctgga gcgcgtggcc cgctacaaca gcaccaacgt 12395 gcagacgaac ctggaccgca tggtgaccga cgtgcgcgag gcggtgtcgc agcgcgagcg 12455 gttccaccgc gagtcgaacc tgggctccat ggtggcgctg aacgccttcc tgagcacgca 12515 gcccgccaac gtgccccggg gccaggagga ctacaccaac tttatcagcg cgctgcggct 12575 gatggtggcc gaggtgcccc agagcgaggt gtaccagtcg gggccggact acttcttcca 12635 gaccagtcgc cagggcttgc agaccgtgaa cctgagccag gctttcaaga acttgcaggg 12695 actgtggggc gtgcaggccc cggtcgggga ccgcgcgacg gtgtcgagcc tgctgacgcc 12755 gaactcgcgc ctgctgctgc tgctggtggc gcccttcacg gacagcggca gcgtgagccg 12815 cgactcgtac ctgggctacc tgcttaacct gtaccgcgag gccatcgggc aggcgcacgt 12875 ggacgagcag acctaccagg agatcaccca cgtgagccgc gcgctgggcc aggaggaccc 12935 gggcaacctg gaggccaccc tgaacttcct gctgaccaac cggtcgcaga agatcccgcc 12995 ccagtacgcg ctgagcaccg aggaggagcg catcctgcgc tacgtgcagc agagcgtggg 13055 gctgttcctg atgcaggagg gggccacgcc cagcgccgcg ctcgacatga ccgcgcgcaa 13115 catggagccc agcatgtacg cccgcaaccg cccgttcatc aataagctga tggactactt 13175 gcatcgggcg gccgccatga actcggacta ctttaccaac gccatcttga acccgcactg 13235 gctcccgccg cccgggttct acacgggcga gtacgacatg cccgacccca acgacgggtt 13295 cctgtgggac gacgtggaca gcagcgtgtt ctcgccgcgc cccaccacca ccgtgtggaa 13355 gaaagagggc ggggaccggc ggccgtcctc ggcgctgtcc ggtcgcgcgg gtgctgccgc 13415 ggcggtgccc gaggccgcca gccccttccc gagcctgccc ttttcgctga acagcgtgcg 13475 cagcagcgag ctgggtcggc tgacgcggcc gcgcctgctg ggcgaggagg agtacctgaa 13535 cgactccttg ttgaggcccg agcgcgagaa aaacttcccc aataacggga tagagagcct 13595 ggtggacaag atgagccgct ggaagacgta cgcgcacgag cacagggacg agccccgagc 13655 tagcagcagc gccggcgcca cccgtagacg ccagcggcac gacaggcagc ggggactggt 13715 gtgggacgat gaggattccg ccgacgacag cagcgtgttg gacttgggtg ggagtggtgg 13775 tggtaacccg ttcgctcact tgcgcccccg tatcgggcgc ctgatgtaag aatctgaaaa 13835 aataaaaaaa cggtactcac caaggccatg gcgaccagcg tgcgttcttc tctgttgttt 13895 gtagtagtat gatgaggcgc gtgtacccgg agggtcctcc tccctcgtac gagagcgtga 13955 tgcagcaggc ggtggcggcg gcgatgcagc ccccgctgga ggcgccttac gtgcccccgc 14015 ggtacctggc gcctacggag gggcggaaca gcattcgtta ctcggagctg gcacccttgt 14075 acgataccac ccggttgtac ctggtggaca acaagtcggc ggacatcgcc tcgctgaact 14135 accagaacga ccacagcaac ttcctgacca ccgtggtgca gaacaacgat ttcaccccca 14195 cggaggccag cacccagacc atcaactttg acgagcgctc gcggtggggc ggccagctga 14255 aaaccatcat gcacaccaac atgcccaacg tgaacgagtt catgtacagc aacaagttca 14315 aggcgcgggt gatggtctcg cgcaagaccc ccaacggggt gacggtggat gagaattatg 14375 atggtagtca ggacgagctg acctacgagt gggtggagtt tgagctgccc gagggcaact 14435 tctcggtgac catgaccatc gatctgatga acaacgccat catcgacaac tacttggcgg 14495 tgggacggca gaacggggtg ctggagagcg acatcggcgt gaagttcgac acgcgcaact 14555 tccggctggg ctgggacccc gtgaccgagc tggtgatgcc gggcgtgtac accaacgagg 14615 ccttccaccc cgacatcgtc ctgctgcccg gctgcggcgt ggacttcacc gagagccgcc 14675 tcagcaacct gctgggcatc cgcaagcggc agcccttcca ggagggcttc cagatcctgt 14735 acgaggacct ggaggggggc aacatccccg cgctgctgga cgtcgaagcc tacgagaaaa 14795 gcaaggagga ggccgccgca gcggcgaccg cggccgtggc taccgctgcg accaccgatg 14855 cagatgcagc tactactacc aggggcgata cattcgccac ccaggcggag gaagcagccg 14915 ccctagcggc gaccgatgat agtgaaagta agatagtcat caagccggtg gagaaggaca 14975 gcaaggacag gagctacaac gttctatcgg atggaaagaa caccgcctac cgcagctggt 15035 acctggccta caactacggc gaccctgaga agggcgtgcg ctcctggacg ctgctcacca 15095 cctcggacgt cacctgcggc gtggagcaag tctactggtc gctgcccgac atgatgcaag 15155 acccggtcac cttccgctcc acgcgtcaag ttagcaacta cccggtggtg ggcgccgagc 15215 tcctgcccgt ctactccaag agcttcttca acgagcaggc cgtctactcg cagcagctgc 15275 gcgccttcac ctcgctcacg cacgtcttca accgcttccc cgagaaccag atcctcgtcc 15335 gcccgcccgc gcccaccatt accaccgtca gtgaaaacgt tcctgctctc acagatcacg 15395 ggaccctgcc gctgcgcagc agtatccggg gagtccagcg cgtgaccgtc actgacgcca 15455 gacgccgcac ctgcccctac gtctacaagg ccctgggcgt agtcgcgccg cgcgtcctct 15515 cgagccgcac cttctaaaaa atgtccattc tcatctcgcc cagtaataac accggttggg 15575 gcctgcgcgc gcccagcaag atgtacggag gcgctcgcca acgctccacg caacaccccg 15635 tgcgcgtgcg cgggcacttc cgcgctccct ggggcgccct caagggccgc gtgcgctcgc 15695 gcaccaccgt cgacgacgtg atcgaccagg tggtggccga cgcgcgcaac tacacgcccg 15755 ccgccgcgcc cgcctccacc gtggacgccg tcatcgacag cgtggtggcc gacgcgcgcc 15815 ggtacgcccg cgccaagagc cggcggcggc gcatcgcccg gcggcaccgg agcacccccg 15875 ccatgcgcgc ggcgcgagcc ttgctgcgca gggccaggcg cacgggacgc agggccatgc 15935 tcagggcggc cagacgcgcg gcctccggca gcagcagcgc cggcaggacc cgcagacgcg 15995 cggccacggc ggcggcggcg gccatcgcca gcatgtcccg cccgcggcgc ggcaacgtgt 16055 actgggtgcg cgacgccgcc accggtgtgc gcgtgcccgt gcgcacccgc ccccctcgca 16115 cttgaagatg ctgacttcgc gatgttgatg tgtcccagcg gcgaggagga tgtccaagcg 16175 caaattcaag gaagagatgc tccaggtcat cgcgcctgag atctacggcc ccgcggcggc 16235 ggtgaaggag gaaagaaagc cccgcaaact gaagcgggtc aaaaaggaca aaaaggagga 16295 ggaagatgac ggactggtgg agtttgtgcg cgagttcgcc ccccggcggc gcgtgcagtg 16355 gcgcgggcgg aaagtgaaac cggtgctgcg gcccggcacc acggtggtct tcacgcccgg 16415 cgagcgttcc ggctccgcct ccaagcgctc ctacgacgag gtgtacgggg acgaggacat 16475 cctcgagcag gcggccgagc gtctgggcga gtttgcttac ggcaagcgca gccgccccgc 16535 gcccttgaaa gaggaggcgg tgtccatccc gctggaccac ggcaacccca cgccgagcct 16595 gaagccggtg accctgcagc aggtgctgcc gagcgcggcg ccgcgccggg gcttcaagcg 16655 cgagggcggc gaggatctgt acccgaccat gcagctgatg gtgcccaagc gccagaagct 16715 ggaggacgtg ctggagcaca tgaaggtgga ccccgaggtg cagcccgagg tcaaggtgcg 16775 gcccatcaag caggtggccc cgggcctggg cgtgcagacc gtggacatca agatccccac 16835 ggagcccatg gaaacgcaga ccgagcccgt gaagcccagc accagcacca tggaggtgca 16895 gacggatccc tggatgccgg cgccggcttc caccaccacc accacccgcc gaagacgcaa 16955 gtacggcgcg gccagcctgc tgatgcccaa ctacgcgctg catccttcca tcatccccac 17015 gccgggctac cgcggcacgc gcttctaccg cggctacagc agccgccgca agaccaccac 17075 ccgccgccgc cgtcgccgca cccgccgcag caccaccgcg acttccgccg ccgccttggt 17135 gcggagagtg taccgcagcg ggcgtgagcc tctgaccctg ccgcgcgcgc gctaccaccc 17195 gagcatcgcc atttaactct gccgtcgcct ccttgcagat atggccctca catgccgcct 17255 ccgcgtcccc attacgggct accgaggaag aaagccgcgc cgtagaaggc tgacggggaa 17315 cgggctgcgt cgccatcacc accggcggcg gcgcgccatc agcaagcggt tggggggagg 17375 cttcctgccc gcgctgatcc ccatcatcgc cgcggcgatc ggggcgatcc ccggcatagc 17435 ttccgtggcg gtgcaggcct ctcagcgcca ctgagacaca gcttggaaaa tttgtaataa 17495 aaaaatggac tgacgctcct ggtcctgtga tgtgtgtttt tagatggaag acatcaattt 17555 ttcgtccctg gcaccgcgac acggcacgcg gccgtttatg ggcacctgga gcgacatcgg 17615 caacagccaa ctgaacgggg gcgccttcaa ttggagcagt ctctggagcg ggcttaagaa 17675 tttcgggtcc acgctcaaaa cctatggcag caaggcgtgg aacagcacca cagggcaggc 17735 gctgagggat aagctgaaag agcagaactt ccagcagaag gtggtcgatg ggctcgcttc 17795 gggcatcaac ggggtggtgg acctggccaa ccaggccgtg cagcggcaga tcaacagccg 17855 cctggacccg gtgccgcccg ccggctccgt ggagatgccg caggtggagg aggagctgcc 17915 tcccctggac aagcggggcg agaagcgacc ccgccccgac gcggaggaga cgctgctgac 17975 gcacacggac gagccgcccc cgtacgagga ggcggtgaaa ctgggtctgc ccaccacgcg 18035 gcccattgcg cccctagcca ccggggtgct gaaacccgag agtaataagc ccgcgaccct 18095 ggacttgcct cctccccagc cttcccgccc ctccacagtg gctaagcccc tgccgccggt 18155 ggccgtggcc cgcgcgcgac ccgggggctc cgcccgccct catgcgaact ggcagagcac 18215 tctgaacagc atcgtgggtc tgggagtgca gagtgtgaag cgccgccgct gctattaaac 18275 ctaccgtagc gcttaacttg cttgtctgtg tgtgtatgta ttatgtcgcc gccgctgtcc 18335 gccagaagga ggagtgaaga ggcgcgtcgc cgagttgcaa gatggccacc ccatcgatgc 18395 tgccccagtg ggcgtacatg cacatcgccg gacaggacgc ttcggagtac ctgagtccgg 18455 gtctggtgca gttcgcccgc gccacagaca cctacttcag tctggggaac aagtttagga 18515 accccacggt ggcgcccacg cacgatgtga ccaccgaccg cagccagcgg ctgacgctgc 18575 gcttcgtgcc cgtggaccgc gaggacaaca cctactcgta caaagtgcgc tacacgctgg 18635 ccgtgggcga caaccgcgtg ctggacatgg ccagcaccta ctttgacatc cgcggcgtgc 18695 tggaccgggg ccctagcttc aaaccctact ccggcaccgc ctacaacagc ctggctccca 18755 agggagcgcc caattccagc cagtgggagc gagctaagac aaacaataac ggagccacgg 18815 aatctgttac ctttggtgtg gctgccatgg ggggtataga tattacaaaa gagggtctcc 18875 agattggaac tgatgaaact aaagctgata gtaaagaaat ttatgcagac aaaacctacc 18935 aacctgaacc tcagatagga gaggagaact ggcaagaaac attctcctat tatggcggca 18995 gagctcttaa aaaagatacc aagatgaagc catgctacgg ctcctttgct aaaccaacga 19055 atgtcaaagg aggtcaggcc aaatttaaag ttcaggacgg tcaacaaact acagaatatg 19115 atatcgactt agctttcttt gatattccaa actctggaac aggagggaat ggcacgaatg 19175 ttaattatga tccagatatg gtcatgtaca ctgaaaatgt ggatttggag acccctgata 19235 cccacattgt ttacaaacca gggacttccg atgacagttc tgaagcaaac ttgcttcagc 19295 agtccatgcc taacagaccc aactatattg ggtttagaga caactttatc ggtctcatgt 19355 actacaacag tactggcaat atgggtgtgc tggctggtca ggcctcccag ctgaatgctg 19415 tggtcgactt gcaagacaga aacaccgagc tatcctacca gctcttgctt gactctctgg 19475 gcgatagaac ccggtatttc agtatgtgga accaggcggt ggacagttat gaccctgatg 19535 tgcgcattat tgaaaaccat ggtgtggaag atgaacttcc caactattgc ttcccattgg 19595 atggagctgg tactaatgct gtctatcagg gtgttaaagc aaaaactaat ggaggcgcag 19655 ccaatggaga ttgggagcaa gatacagacg tgtcaaacat taaccagata tgcaagggga 19715 acatctatgc catggaaatc aacctccaag ccaacctgtg gagaagtttc ctctactcga 19775 acgtggccct gtacctgccc gattcttaca agtacacgcc ggccaacatc accttgccca 19835 cgaataccaa cacctatgat tacatgaatg ggagagtggc gcctccctcg ttggtggatg 19895 cctacatcaa catcggggcg cgctggtcgc tggaccccat ggacaacgtc aatcccttca 19955 accaccaccg caacgcgggg ctgcgctacc gctccatgct tctgggcaac gggcgcttcg 20015 tgcccttcca catccaggtg ccccagaaat ttttcgccat caagagcctc ctgctcctgc 20075 ccgggtccta cacctacgag tggaacttcc gcaaggacgt caacatgatc ctgcagagct 20135 ccctcggcaa cgacctgcgc acggacgggg cctccatctc cttcaccagc atcaacctct 20195 acgccacctt cttccccatg gcgcacaaca cggcctccac gctcgaggcc atgctgcgca 20255 acgacaccaa cgaccagtcc ttcaacgact acctctcggc ggccaacatg ctctacccca 20315 tcccagccaa cgccaccaac gtgcccatct ccatcccctc gcgcaactgg gccgccttcc 20375 gcggctggtc cttcacgcgt ctcaagacca aggagacgcc ctcgctgggc tccgggttcg 20435 acccctactt cgtctactcg ggctccatcc cctacctcga cggcaccttc tacctcaacc 20495 acaccttcaa gaaggtctcc atcaccttcg actcctccgt cagctggccc ggcaacgacc 20555 ggctcctgac gcccaacgag ttcgaaatca agcgcaccgt cgacggcgag ggctacaacg 20615 tggcccagtg caacatgacc aaggactggt tcctggtcca gatgctggcc cactacaaca 20675 tcggctacca gggcttctac gtgcccgagg gctacaagga ccgcatgtac tccttcttcc 20735 gcaacttcca gcccatgagc cgccaggtgg tggacgaggt caactacaag gactaccagg 20795 ccgtcaccct ggcctaccag cacaacaact cgggcttcgt cggctacctc gcgcccacca 20855 tgcgccaggg ccagccctac cccgccaact acccgtaccc gctcatcggc aagagcgccg 20915 tcaccagcgt cacccagaaa aagttcctct gcgacagggt catgtggcgc atccccttct 20975 ccagcaactt catgtccatg ggcgcgctca ccgacctcgg ccagaacatg ctctatgcca 21035 actccgccca cgcgctagac atgaatttcg aagtcgaccc catggatgag tccacccttc 21095 tctatgttgt cttcgaagtc ttcgacgtcg tccgagtgca ccagccccac cgcggcgtca 21155 tcgaggccgt ctacctgcgc acccccttct cggccggtaa cgccaccacc taagctcttg 21215 cttcttgcaa gatggctgag cccacgggct ccggcgagca ggagctcagg gccatcatcc 21275 gcgacctggg ctgcgggccc tacttcctgg gcaccttcga taagcgcttc ccgggattca 21335 tggccccgca caagctggcc tgcgccatcg tcaacacggc cggccgcgag accgggggcg 21395 agcactggct ggccttcgcc tggaacccgc gctcgaacac ctgctacctc ttcgacccct 21455 tcgggttctc ggacgagcgc ctcaagcaga tctaccagtt cgagtacgag ggcctgctgc 21515 gccgcagcgc cctggccacc gaggaccgct gcgtcaccct ggaaaagtcc acccagaccg 21575 tgcagggtcc gcgctcggcc gcctgcgggc tcttttgctg catgttcctg cacgccttcg 21635 tgcactggcc cgaccgcccc atggacaaga accccaccat gaacttgctg acgggggtgc 21695 ccaacggcat gctccagtcg ccccaggtgg aacccaccct gcgccgcaac caggaggcgc 21755 tctaccgctt cctcaacgcc cactccgcct actttcgctc ccaccgcgcg cgcatcgaga 21815 aggccaccgc cttcgaccgc atgaatcaag acatgtaaac cgtgtgtgta tgtgaatgct 21875 ttattcataa taaacagcac atgtttatgc caccttctct gaggctctga ctttatttag 21935 aaatcgaagg ggttctgccg gctctcggcg tgccccgcgg gcagggatac gttgcggaac 21995 tggtacttgg gcagccactt gaactcgggg atcagcagct tcggcacggg gaggtcgggg 22055 aacgagtcgc tccacagctt gcgcgtgagt tgcagggcgc ccagcaggtc gggcgcggag 22115 atcttgaaat cgcagttggg acccgcgttc tgcgcgcgag agttgcggta cacggggttg 22175 cagcactgga acaccatcag ggccgggtgc ttcacgctcg ccagcaccgt cgcgtcggtg 22235 atgccctcca cgtccagatc ctcggcgttg gccatcccga agggggtcat cttgcaggtc 22295 tgccgcccca tgctgggcac gcagccgggc ttgtggttgc aatcgcagtg cagggggatc 22355 agcatcatct gggcctgctc ggagctcatg cccgggtaca tggccttcat gaaagcctcc 22415 agctggcgga aggcctgctg cgccttgccg ccctcggtga agaagacccc gcaggacttg 22475 ctagagaact ggttggtagc gcagcccgcg tcgtgcacgc agcagcgcgc gtcgttgttg 22535 gccagctgca ccacgctgcg cccccagcgg ttctgggtga tcttggcccg gtcggggttc 22595 tccttcagcg cgcgctgccc gttctcgctc gccacatcca tctcgatcgt gtgctccttc 22655 tggatcatca cggtcccgtg caggcaccgc agcttgccct cggcctcggt gcagccgtgc 22715 agccacagcg cgcagccggt gctctcccag ttcttgtggg cgatctggga gtgcgagtgc 22775 acgaagccct gcaggaagcg gcccatcatc gcggtcaggg tcttgttgct ggtgaaggtc 22835 agcgggatgc cgcggtgctc ctcgttcaca tacaggtggc agatgcggcg gtacacctcg 22895 ccctgctcgg gcatcagctg gaaggcggac ttcaggtcgc tctccacgcg gtaccggtcc 22955 atcagcagcg tcatcacttc catgcccttc tcccaggccg aaacgatcgg caggctcagg 23015 gggttcttca ccgtcatctt agtcgccgcc gccgaagtca gggggtcgtt ctcgtccagg 23075 gtctcaaaca ctcgcttgcc gtccttctcg gtgatgcgca cgggggggaa ggcgaagccc 23135 acggccgcca gctcctcctc ggcctgcctt tcgtcctcgc tgtcctggct gatgtcttgc 23195 aaaggcacat gcttggtctt gcggggtttc tttttgggcg gcagaggcgg cggcggcgga 23255 gacgtgctgg gcgagcgcga gttctcgctc accacgacta tttcttcttc ttggccgtcg 23315 tccgagacca cgcggcggta ggcatgcctc ttctggggca gaggcggagg cgacgggctc 23375 tcgcggttcg gcgggcggct ggcagagccc cttccgcgtt cgggggtgcg ctcctggcgg 23435 cgctgctctg actgacttcc tccgcggccg gccattgtgt tctcctaggg agcaacaaca 23495 agcatggaga ctcagccatc gtcgccaaca tcgccatctg cccccgccgc cgccgacgag 23555 aaccagcagc agcagaatga aagcttaacc gccccgccgc ccagccccac ctccgacgcc 23615 gcggccccag acatgcaaga gatggaggaa tccatcgaga ttgacctggg ctacgtgacg 23675 cccgcggagc acgaggagga gctggcagcg cgcttttcag ccccggaaga gaaccaccaa 23735 gagcagccag agcaggaagc agagagcgag cagagccagg ctgggctcga gcatggcgac 23795 tacctgagcg gggcagagga cgtgctcatc aagcatctgg cccgccaatg catcatcgtc 23855 aaggacgcgc tgctcgaccg cgccgaggtg cccctcagcg tggcggagct cagccgcgcc 23915 tacgagcgca acctcttctc gccgcgcgtg ccccccaagc gccagcccaa cggcacctgc 23975 gagcccaacc cgcgcctcaa cttctacccg gtcttcgcgg tgcccgaggc cctggccacc 24035 taccacctct ttttcaagaa ccaaaggatc cccgtctcct gccgcgccaa ccgcacccgc 24095 gccgacgccc tgctcaacct gggccccggc gcccgcctac ctgatatcgc ctccttggaa 24155 gaggttccca agatcttcga gggtctgggc agcgacgaga ctcgggccgc gaacgctctg 24215 caaggaagcg gagaggagca tgagcaccac agcgccctgg tggagttgga aggcgacaac 24275 gcgcgcctgg cggtcctcaa gcgcacggtc gagctgaccc acttcgccta cccggcgctc 24335 aacctgcccc ccaaggtcat gagcgccgtc atggaccagg tgctcatcaa gcgcgcctcg 24395 cccctctcgg aggaggagat gcaggacccc gagagctcgg acgagggcaa gcccgtggtc 24455 agcgacgagc agctggcgcg ctggctggga acgagtagca ccccccagag tctggaagag 24515 cggcgcaagc tcatgatggc cgtggtcctg gtgaccgtgg agcttgagtg tctgcgccgc 24575 ttcttcgccg acgcggagac cctgcgcaag gtcgaggaga acctgcacta cctcttcagg 24635 cacgggttcg tgcgccaggc ctgcaagatc tccaacgtgg agctgaccaa cctggtctcc 24695 tacatgggca tcctgcacga gaaccgcctg gggcagaacg tgctgcacac caccctgcgc 24755 ggggaggccc gccgcgacta catccgcgac tgcgtctacc tgtacctctg ccacacctgg 24815 cagacgggca tgggcgtgtg gcagcagtgc ctggaggagc agaacctgaa agagctctgc 24875 aagctcctgc agaagaacct gaaggccctg tggaccgggt tcgacgagcg taccaccgcc 24935 tcggacctgg ccgacctcat cttccccgag cgcctgcggc tgacgctgcg caacgggctg 24995 cccgacttta tgagccaaag catgttgcaa aactttcgct ctttcatcct cgaacgctcc 25055 gggatcctgc ccgccacctg ctccgcgctg ccctcggact tcgtgccgct gaccttccgc 25115 gagtgccccc cgccgctctg gagccactgc tacttgctgc gcctggccaa ctacctggcc 25175 taccactcgg acgtgatcga ggacgtcagc ggcgagggtc tgctcgagtg ccactgccgc 25235 tgcaacctct gcacgccgca ccgctccctg gcctgcaacc cccagctgct gagcgagacc 25295 cagatcatcg gcaccttcga gttgcaaggc cccggcgagg agggcaaggg gggtctgaaa 25355 ctcaccccgg ggctgtggac ctcggcctac ttgcgcaagt tcgtgcccga ggactaccat 25415 cccttcgaga tcaggttcta cgaggaccaa tcccagccgc ccaaggccga gctgtcggcc 25475 tgcgtcatca cccagggggc catcctggcc caattgcaag ccatccagaa atcccgccaa 25535 gaatttctgc tgaaaaaggg ccacggggtc tacttggacc cccagaccgg agaggagctc 25595 aaccccagct tcccccagg atg ccc aga gga agc agc aag aag ctg aaa gtg 25647 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val 505 510 515 gag ctg ccg ctg ccg ccg gag gat ttg gag gaa gac tgg gag agc agt 25695 Glu Leu Pro Leu Pro Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser 520 525 530 cag gca gag gag gag gag atg gaa gac tgg gac agc act cag gca gag 25743 Gln Ala Glu Glu Glu Glu Met Glu Asp Trp Asp Ser Thr Gln Ala Glu 535 540 545 gag gac agc ctg caa gac agt ctg gaa gac gag gtg gag gag gca gag 25791 Glu Asp Ser Leu Gln Asp Ser Leu Glu Asp Glu Val Glu Glu Ala Glu 550 555 560 gaa gaa gca gcc gcc gcc aga ccg tcg tcc tcg gcg gag aaa gca agc 25839 Glu Glu Ala Ala Ala Ala Arg Pro Ser Ser Ser Ala Glu Lys Ala Ser 565 570 575 agc acg gat acc atc tcc gct ccg ggt cgg ggt ctc ggc ggc cgg gcc 25887 Ser Thr Asp Thr Ile Ser Ala Pro Gly Arg Gly Leu Gly Gly Arg Ala 580 585 590 595 cac agt aga tgg gac gag acc ggg cgc ttc ccg aac ccc acc acc cag 25935 His Ser Arg Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln 600 605 610 acc ggt aag aag gag cgg cag gga tac aag tcc tgg cgg ggg cac aaa 25983 Thr Gly Lys Lys Glu Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys 615 620 625 aac gcc atc gtc tcc tgc ttg caa gcc tgc ggg ggc aac atc tcc ttc 26031 Asn Ala Ile Val Ser Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe 630 635 640 acc cgg cgc tac ctg ctc ttc cac cgc ggg gtg aac ttc ccc cgc aac 26079 Thr Arg Arg Tyr Leu Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn 645 650 655 atc ttg cat tac tac cgt cac ctc cac agc ccc tac tac tgt ttc caa 26127 Ile Leu His Tyr Tyr Arg His Leu His Ser Pro Tyr Tyr Cys Phe Gln 660 665 670 675 gaa gag gca gaa acc cag cag cag cag aaa acc agc agc agc 26169 Glu Glu Ala Glu Thr Gln Gln Gln Gln Lys Thr Ser Ser Ser 680 685 tagaaaatcc acagcggcgg cggcggcagg tggactgagg atcgcggcga acgagccggc 26229 gcagacccgg gagctgagga accggatctt tcccaccctc tatgccatct tccagcagag 26289 tcgggggcag gagcaggaac tgaaagtcaa gaaccgttct ctgcgctcgc tcacccgcag 26349 ttgtctgtat cacaagagcg aagaccaact tcagcgcact ctcgaggacg ccgaggctct 26409 cttcaacaag tactgcgcgc tcactcttaa agagtagccc gcgcccgccc acacacggaa 26469 aaaggcggga attacgtcac cacctgcgcc cttcgcccga ccatcatcat gagcaaagag 26529 attcccacgc cttacatgtg gagctaccag ccccagatgg gcctggccgc cggcgccgcc 26589 caggactact ccacccgcat gaactggctc agtgccgggc ccgcgatgat ctcacgggtg 26649 aatgacatcc gcgcccaccg aaaccagata ctcctagaac agtcagcgat caccgccacg 26709 ccccgccatc accttaatcc gcgtaattgg cccgccgccc tggtgtacca ggaaattccc 26769 cagcccacga ccgtactact tccgcgagac gcccaggccg aagtccagct gactaactca 26829 ggtgtccagc tggccggcgg cgccgccctg tgtcgtcacc gccccgctca gggtataaag 26889 cggctggtga tccgaggcag aggcacacag ctcaacgacg aggtggtgag ctcttcgctg 26949 ggtctgcgac ctgacggagt cttccaactc gccggatcgg ggagatcttc cttcacgcct 27009 cgtcaggccg tcctgacttt ggagagttcg tcctcgcagc cccgctcggg tggcatcggc 27069 actctccagt tcgtggagga gttcactccc tcggtctact tcaacccctt ctccggctcc 27129 cccggccact acccggacga gttcatcccg aacttcgacg ccatcagcga gtcggtggac 27189 ggctacgatt gaatgtccca tggtggcgcg gctgacctag ctcggcttcg acacctggac 27249 cactgccgcc gcttccgctg cttcgctcgg gatctcgccg agtttgccta ctttgagctg 27309 cccgaggagc accctcaggg cccggcccac ggagtgcgga tcatcgtcga agggggcctc 27369 gactcccacc tgcttcggat cttcagccag cgtccgatcc tggtcgagcg cgagcaagga 27429 cagacccgtc tgaccctgta ctgcatctgc aaccaccccg gcctgc atg aaa gtc 27484 Met Lys Val 690 ttt gtt gtc tgc tgt gta ctg agt ata ata aaa gct gag atc agc gac 27532 Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu Ile Ser Asp 695 700 705 tac tcc gga ctt ccg tgt gtt cct gaa tcc atc aac cag tcc ctg ttc 27580 Tyr Ser Gly Leu Pro Cys Val Pro Glu Ser Ile Asn Gln Ser Leu Phe 710 715 720 ttc acc ggg aac gag acc gag ctc cag ctc cag tgt aag ccc cac aag 27628 Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys Pro His Lys 725 730 735 740 aag tac ctc acc tgg ctg ttc cag ggc tcc ccg atc gcc gtt gtc aac 27676 Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala Val Val Asn 745 750 755 cac tgc gac aac gac gga gtc ctg ctg agc ggc cct gcc aac ctt act 27724 His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala Asn Leu Thr 760 765 770 ttt tcc acc cgc aga agc aag ctc cag ctc ttc caa ccc ttc ctc ccc 27772 Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro Phe Leu Pro 775 780 785 ggg acc tat cag tgc gtc tcg gga ccc tgc cat cac acc ttc cac ctg 27820 Gly Thr Tyr Gln Cys Val Ser Gly Pro Cys His His Thr Phe His Leu 790 795 800 atc ccg aat acc aca gcg tcg ctc ccc gct act aac aac caa act acc 27868 Ile Pro Asn Thr Thr Ala Ser Leu Pro Ala Thr Asn Asn Gln Thr Thr 805 810 815 820 cac caa cgc cac cgt cgc gac ctt tcc tct gaa tct aat acc act acc 27916 His Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser Asn Thr Thr Thr 825 830 835 gga ggt gag ctc cga ggt cga cca acc tct ggg att tac tac ggc ccc 27964 Gly Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile Tyr Tyr Gly Pro 840 845 850 tgg gag gtg gtg ggg tta ata gcg cta ggc cta gtt gtg ggt ggg ctt 28012 Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val Val Gly Gly Leu 855 860 865 ttg gct ctc tgc tac cta tac ctc cct tgc tgt tcg tac tta gtg gtg 28060 Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser Tyr Leu Val Val 870 875 880 ctg tgt tgc tgg ttt aag aaa tgg ggc aga tca ccc tagtgagctg 28106 Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 885 890 895 cggtgtgctg gtggcggtgg tgctttcgat tgtgggactg ggcggcgcgg ctgtagtgaa 28166 ggagaaggcc gatccctgct tgcatttcaa tcccgataaa tgccagctga gttttcagcc 28226 cgatggcaat cggtgcgcgg tgctgatcaa gtgcggatgg gaatgcgaga acgtgagaat 28286 cgagtacaat aacaagactc ggaacaatac tctcgcgtcc acgtggcagc ccggggaccc 28346 cgagtggtac accgtctctg tccccggtgc tgacggctcc ccgcgcaccg tgaataatac 28406 tttcattttt gcgcacatgt gcgacacggt catgtggatg agcaagcagt acgatatgtg 28466 gccccccacg aaggagaaca tcgtggtctt ctccatcgct tacagcctgt gcacggtgct 28526 aatcaccgct atcgtgtgcc tgagcattca catgctcatc gctattcgcc ccagaaataa 28586 tgccgaaaaa gaaaaacagc cataacacgt tttttcacac acctttttca gaccatggcc 28646 tctgttaaat ttttgctttt atttgccagt ctcattactg ttataagtaa tgagaaactc 28706 actatttaca ttggcactaa ccacactcta gaaggaattc caaaatcctc atggtattgc 28766 tattttgatc aagatccaga cttaactata gaactgtgtg gtaacaaggg acaaaataca 28826 agcattcatt taattaactt taaatgcgga gacgatttga aattaattaa tatcactaaa 28886 gagtatggag gtatgtatta ctatgttaca gaaaataaca acatgcagtt ttatgaagtt 28946 actgtaacta atcccaccac gcctagaaca acaacaacca ccacaaagac tacacctgtt 29006 accactatgc agctcactac caataacatt tttgccatgc gtcagaaggc caacaatagc 29066 accagcattc aacccccccc acccagtgag gaaattccca aatccatgat tggcattatt 29126 gttgctgtag tggtgtgcat gttgatcatc gccttgtgca tggtgtacta tgccttctgc 29186 tacagaaagc acagactgaa cgacaagcta gaacacttac taagtgttga attttaattt 29246 ttttagaacc atgaagatcc taggcctttt aattttttct atcattacct ctgctctatg 29306 caattctgac aatgaggacg ttactgtcgt tgtcggatca aattatacac tgaaaggtcc 29366 agcgaagggt atgctttcgt ggtattgctg gtttggaact gacactgaac aaaccgaatt 29426 atgcaatctt caaaatggca aagttcataa ttctaaaatt tacaattata tatgcaatgg 29486 cactgatttg atactcctca atatcacgaa atcatatgct ggcagttatt catgccctgg 29546 agatgatgct gacaatatga ttttttataa attgcaagtg gttgatccca ctactccacc 29606 tccacccacc acaactactc acaccacaca cacagaacaa accacagcag aggaggcggc 29666 aaagttagct ttgcaggtcc aagacagttc atttgttggc attaccccta cacccgatca 29726 gcggtgtccg gggctgctcg tcagcggcat tgtcggtgtg ctttcgggat tagcagttat 29786 aatcatctgc atgttcattt ttgcttgctg ctatagaagg ctttaccgac aaaaatcaga 29846 cccactgctg aacctctatg tttaattttt tccagagcca tgaaggcagt tagcgctcta 29906 gttttttgtt ctttgattgg cactgttttt agtgttagct ttttaaaaca aattaatgtt 29966 actgaggggg aaaatgtgac actggtaggc gtagaaggtg ctcaaaatac cacctggaca 30026 aaataccacc tcgatgggtg gaaagatatt tgcaattgga gtgtcattac ttacacatgt 30086 gagggagtta atttgaccat agtcaatgcc agccaaaatc agaagggttg gattaaaggg 30146 caatctgtta gtgttaccag tgaggggtac tatacccagc atactcttat ctatgacatt 30206 atagtcatac cgctgcctac gcctagccca cctagcacta ccacacagac aacccacact 30266 acacaaacaa ccacatacag tacatcaaat cagcctacca ccactacaac agcagaggtt 30326 gccagctcgt ctggggtccg agcggcattt ttgatgttgg ccccatctag cagtcccact 30386 gctagtacca atgagcagac tactgaattt ttgtccactg tcgagagcca caccacagct 30446 acctcgagtg ccttctctag caccgccaat ctctcctcgc tttcctctac accaatcagt 30506 cccgctacta ctactacccc cgctattctt cccactcccc tgaagcaaac tgaggacagc 30566 ggcatgcaat ggcagatcac cctgctcatt gtgatcgggt tggtcatcct agccgtgttg 30626 ctctactaca tcttccgccg ccgcattccc aacgcgcacc gcaagccggt ctacaagccc 30686 atcattgtcg ggcagccgga gccgcttcag gtggaagggg gtctaaggaa tcttctcttc 30746 tcttttacag tatggtgatt gaactatgat tcctagacaa ttcttgatca ctattcttat 30806 ctgcctcctc caagtctgtg ccaccctcgc tctggtggcc aacgccagtc cagactgtat 30866 tgggcccttc gcctcctacg tgctctttgc cttcatcacc tgcatctgct gctgtagcat 30926 agtctgcctg cttatcacct tcttccagtt cattgactgg atctttgtgc gcatcgccta 30986 cctgcgccac cacccccagt accgcgacca gcgagtggcg cagctgctca ggctcctctg 31046 ataagcatgc gggctctgct acttctcgcg cttctgctgt tagtgctccc ccgtcccgtt 31106 gacccccggc cccccactca gtcccccgag gaggtccgca aatgcaaatt ccaagaaccc 31166 tggaaattcc tcaaatgcta ccgccaaaaa tcagacatgc atcccagctg gatcatgatc 31226 attgggatcg tgaacattct ggcctgcacc ctcatctcct ttgtgattta cccctgcttt 31286 gactttggtt ggaactcgcc agaggcgctc tatctcccgc ctgaacctga cacaccacca 31346 cagcaacctc aggcacacgc actaccacca ccacagccta ggccacaata catgcccata 31406 ttagactatg aggccgagcc acagcgaccc atgctccccg ctattagtta cttcaatcta 31466 accggcggag atg act gac cca ctg gcc aac aac aac gtc aac gac ctt 31515 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu 900 905 ctc ctg gac atg gac ggc cgc gcc tcg gag cag cga ctc gcc caa ctt 31563 Leu Leu Asp Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu 910 915 920 925 cgc att cgc cag cag cag gag aga gcc gtc aag gag ctg cag gac ggc 31611 Arg Ile Arg Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Gly 930 935 940 ata gcc atc cac cag tgc aag aaa ggc atc ttc tgc ctg gtg aaa cag 31659 Ile Ala Ile His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys Gln 945 950 955 gcc aag atc tcc tac gag gtc acc cag acc gac cat cgc ctc tcc tac 31707 Ala Lys Ile Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser Tyr 960 965 970 gag ctc ctg cag cag cgc cag aag ttc acc tgc ctg gtc gga gtc aac 31755 Glu Leu Leu Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn 975 980 985 ccc atc gtc atc acc cag cag tcg ggc gat acc aag ggg tgc atc cac 31803 Pro Ile Val Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His 990 995 1000 1005 tgc tcc tgc gac tcc ccc gac tgc gtc cac act ctg atc aag acc 31848 Cys Ser Cys Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr 1010 1015 1020 ctc tgc ggc ctc cgc gac ctc ctc ccc atg aac taatcacccc 31891 Leu Cys Gly Leu Arg Asp Leu Leu Pro Met Asn 1025 1030 cttatccag 31900 <210> 46 <211> 504 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 46 Met Glu Ser Arg Asn Pro Phe Gln Gln Gly Leu Pro Ser Gly Leu Leu 1 5 10 15 Ser Ser Ser Phe Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn 20 25 30 Leu Arg Leu Leu Ala Ser Thr Ala Gly Arg His Ala Glu Asp Pro Glu 35 40 45 Ser Pro Val Thr Pro Gly Thr Pro Thr Pro Pro Ala Ala Ala Ala Gly 50 55 60 Ala Ala Ala Arg Gly Gly Gly Gly Pro Arg Arg Glu Pro Glu Ser Arg 65 70 75 80 Ser Gly Pro Ser Gly Gly Gly Gly Gly Gly Val Ala Asp Leu Phe Pro 85 90 95 Glu Leu Arg Arg Val Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly 100 105 110 Ile Lys Arg Glu Arg His Glu Glu Thr Ser His Arg Thr Glu Leu Thr 115 120 125 Val Ser Leu Met Ser Arg Arg Arg Pro Glu Ser Val Trp Trp His Glu 130 135 140 Val Gln Ser Gln Gly Ile Asp Glu Val Ser Val Met His Glu Lys Tyr 145 150 155 160 Ser Leu Glu Gln Val Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp 165 170 175 Glu Val Ala Ile Arg Asn Tyr Ala Lys Leu Ala Leu Lys Pro Asp Lys 180 185 190 Lys Tyr Lys Ile Thr Lys Leu Ile Asn Ile Arg Asn Ser Cys Tyr Ile 195 200 205 Ser Gly Asn Gly Ala Glu Val Glu Ile Ser Thr Gln Glu Arg Val Ala 210 215 220 Phe Arg Cys Cys Met Met Asn Met Tyr Pro Gly Val Val Gly Met Glu 225 230 235 240 Gly Val Thr Phe Met Asn Ala Arg Phe Arg Gly Asp Gly Tyr Asn Gly 245 250 255 Val Val Phe Met Ala Asn Thr Lys Leu Thr Val His Gly Cys Ser Phe 260 265 270 Phe Gly Phe Asn Asn Met Cys Ile Glu Ala Trp Gly Ser Val Ser Val 275 280 285 Arg Gly Cys Ser Phe Ser Ala Asn Trp Met Gly Val Val Gly Arg Thr 290 295 300 Lys Ser Lys Val Ser Val Lys Lys Cys Leu Phe Glu Arg Cys His Leu 305 310 315 320 Gly Val Met Ser Glu Gly Glu Ala Lys Val Lys His Cys Ala Ser Thr 325 330 335 Glu Thr Gly Cys Phe Val Leu Ile Lys Gly Asn Ala Gln Val Lys His 340 345 350 Asn Met Ile Cys Gly Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr 355 360 365 Cys Ala Gly Gly Asn Ser His Met Leu Ala Thr Val His Val Ala Ser 370 375 380 His Pro Arg Lys Thr Trp Pro Glu Phe Glu His Asn Val Met Thr Arg 385 390 395 400 Cys Asn Val His Leu Gly Ser Arg Arg Gly Met Phe Met Pro Tyr Gln 405 410 415 Cys Asn Met Gln Phe Val Lys Val Leu Leu Glu Pro Asp Ala Met Ser 420 425 430 Arg Val Ser Leu Thr Gly Val Phe Asp Met Asn Val Glu Leu Trp Lys 435 440 445 Ile Leu Arg Tyr Asp Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys 450 455 460 Gly Gly Lys His Ala Arg Leu Gln Pro Val Cys Val Glu Val Thr Glu 465 470 475 480 Asp Leu Arg Pro Asp His Leu Val Leu Ser Cys Asn Gly Thr Glu Phe 485 490 495 Gly Ser Ser Gly Glu Glu Ser Asp 500 <210> 47 <211> 185 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 47 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Leu Pro 1 5 10 15 Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu 20 25 30 Glu Met Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln 35 40 45 Asp Ser Leu Glu Asp Glu Val Glu Glu Ala Glu Glu Glu Ala Ala Ala 50 55 60 Ala Arg Pro Ser Ser Ser Ala Glu Lys Ala Ser Ser Thr Asp Thr Ile 65 70 75 80 Ser Ala Pro Gly Arg Gly Leu Gly Gly Arg Ala His Ser Arg Trp Asp 85 90 95 Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys Glu 100 105 110 Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser 115 120 125 Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu 130 135 140 Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr 145 150 155 160 Arg His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu Ala Glu Thr 165 170 175 Gln Gln Gln Gln Lys Thr Ser Ser Ser 180 185 <210> 48 <211> 207 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 48 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Pro Cys Val Pro Glu Ser Ile Asn Gln 20 25 30 Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys 35 40 45 Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala 50 55 60 Val Val Asn His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala 65 70 75 80 Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro 85 90 95 Phe Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro Cys His His Thr 100 105 110 Phe His Leu Ile Pro Asn Thr Thr Ala Ser Leu Pro Ala Thr Asn Asn 115 120 125 Gln Thr Thr His Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser Asn 130 135 140 Thr Thr Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile Tyr 145 150 155 160 Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val Val 165 170 175 Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser Tyr 180 185 190 Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 195 200 205 <210> 49 <211> 135 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 49 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu Leu Leu Asp 1 5 10 15 Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg 20 25 30 Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Gly Ile Ala Ile 35 40 45 His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile 50 55 60 Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser Tyr Glu Leu Leu 65 70 75 80 Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val 85 90 95 Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys 100 105 110 Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu 115 120 125 Arg Asp Leu Leu Pro Met Asn 130 135 <210> 50 <211> 36647 <212> DNA <213> Unknown <220> <223> Simian adenovirus A1331 <220> <221> repeat_region <222> (1)..(129) <223> ITR <220> <221> CDS <222> (1601)..(2173) <223> E1b\19K <220> <221> misc_feature <222> (3988)..(5609) <223> IVa2 complement (3988..5318,5598..5609) <220> <221> misc_feature <222> (5091)..(13857) <223> pol complement (5091..8657,13849..13857) <220> <221> misc_feature <222> (8465)..(13857) <223> pTP complement (8465..10399,13849..13857) <220> <221> CDS <222> (10855)..(12030) <223> 52K <220> <221> CDS <222> (12057)..(13814) <223> pIIIa <220> <221> CDS <222> (13897)..(15513) <223> penton <220> <221> CDS <222> (15520)..(16101) <223> pVII <220> <221> CDS <222> (16149)..(17186) <223> V <220> <221> CDS <222> (17214)..(17444) <223> pX <220> <221> CDS <222> (17517)..(18233) <223> pVI <220> <221> CDS <222> (18337)..(21168) <223> hexon <220> <221> CDS <222> (21190)..(21813) <223> protease <220> <221> misc_feature <222> (21894)..(23429) <223> DBP complement (21894..23429) <220> <221> CDS <222> (23458)..(25866) <223> 100K <220> <221> CDS <222> (26474)..(27154) <223> pVIII <220> <221> CDS <222> (27158)..(27475) <223> E3\12.5K <220> <221> CDS <222> (28040)..(28567) <223> E3\gp19K <220> <221> CDS <222> (28604)..(29287) <223> E3\CR1-beta <220> <221> CDS <222> (29303)..(29911) <223> E3\CR1-gamma <220> <221> CDS <222> (29929)..(30792) <223> E3\CR1-delta <220> <221> CDS <222> (31084)..(31515) <223> E3\RID-beta <220> <221> CDS <222> (32212)..(33546) <223> fiber <220> <221> misc_feature <222> (33644)..(34797) <223> E4\orf6/7 complement (33644..33894,34627..34797) <220> <221> misc_feature <222> (33895)..(34797) <223> E4\orf6 complement (33895..34797) <220> <221> misc_feature <222> (34706)..(35068) <223> E4\orf4 complement (34706..35068) <220> <221> misc_feature <222> (35081)..(35431) <223> E4\orf3 complement (35081..35431) <220> <221> misc_feature <222> (35431)..(35817) <223> E4\orf2 complement (35431..35817) <220> <221> misc_feature <222> (35870)..(36241) <223> E4\orf1 complement (35870..36241) <220> <221> repeat_region <222> (36519)..(36647) <223> ITR <400> 50 cwwymtmwat aatatacctc aaacttttgg tgcgcgttaa tatgcaaatg agccgtttga 60 atttggggat ggaggaaggt gattggctgt gggagcggcg accgttaggg gcggggcggg 120 tgacgttttg atgacgtggc catgaggcgg agccggtttg caagttctcg tgggaaaagt 180 gacgtcaaac gaggtgtggt ttgaacacgg aaatactcaa ttttcccgcg ctctctgaca 240 ggaaatgagg tgtttctggg cggatgcaag tgaaaacggg ccattttcgc gcgaaaactg 300 aatgaggaag tgaaaatctg agtaattccg cgtttatggc agggaggagt atttgccgag 360 ggccgagtag actttgaccg attacgtggg ggtttcgatt accgtatttt tcacctaaat 420 ttccgcgtac ggtgtcaaag tccggtgttt ttacgtaggt gtcagctgat cgccagggta 480 tttaaacctg cgctctctag tcaagaggcc actcttgagt gccagcgagt agagttttct 540 cctccgcgcc gcgagtcaga tctacacttt gaaagatgag gcacctgaga gacctgcccg 600 gtaatgtttt cctggctact gggaacgaga ttctggaact ggtggtggac gccatgatgg 660 gtgacgaccc tcccgagccc cctaccccat ttgaggcgcc ttcgctgtac gatttgtatg 720 atctggaggt ggatgtgtcc gagaacgacc ccaacgagga ggcggtgaat gatttgttta 780 gcgatgccgc gctgctggct gccgagcagg ctaatacgga ctctggctca gacagcgatt 840 cctctctcca taccccgaga cccggcagag gtgagaaaaa gatccccgag cttaaagggg 900 aagagctcga cctgcgctgc tatgaggaat gcttgcctcc gagcgatgat gaggaggacg 960 aggaggcgat tcgagctgca gcgagcgagg gagtgaaagt tgcgggcgag agctttagcc 1020 tggactgtcc tactctgccc ggacacggct gtaagtcttg tgaatttcat cgcatgaata 1080 ctggagataa gaatgtgatg tgtgccctgt gctatatgag agcttacaac cattgtgttt 1140 acagtaagtg tgattaactt tagttgggaa aggcagaggg tgactgggtg ctgactggtt 1200 tatttatgta tatgtttttt atgtgtaggt cccgtctctg acgcagatga gacccccact 1260 tcagagtgca tttcatcacc cccagaaatt ggcgaggaac cgcccgaaga tattattcat 1320 agaccagttg cagtgagagt caccgggcgg agagcagctg tggagagttt ggatgacttg 1380 ctacagggtg gggatgaacc tttggacttg tgtacccgga aacgccccag gcactaagtg 1440 ccacacatgt gtgtttactt aaggtgatgt cagtatttat agggtgtgga gtgcaataaa 1500 aatatgtgtt gactttaagt gcgtgtttta tgactcaggg gtggggactg tgggtatata 1560 agcaggtgca gacctgtgtg gtcagttcag agcaggactc atg gag atc tgg aca 1615 Met Glu Ile Trp Thr 1 5 gtc ttg gaa gac ttt cac cag act aga cag ctg cta gag aac tca tcg 1663 Val Leu Glu Asp Phe His Gln Thr Arg Gln Leu Leu Glu Asn Ser Ser 10 15 20 gag gga gtc tct tac ctg tgg aga ttc tgc ttc gct ggg cct cta gct 1711 Glu Gly Val Ser Tyr Leu Trp Arg Phe Cys Phe Ala Gly Pro Leu Ala 25 30 35 aag cta gtc tat agg gcc aag cag gat tat agg gaa caa ttt gag gat 1759 Lys Leu Val Tyr Arg Ala Lys Gln Asp Tyr Arg Glu Gln Phe Glu Asp 40 45 50 att ttg aga gag tgt cct ggt att ttt gac tct ctc aac ttg ggc cat 1807 Ile Leu Arg Glu Cys Pro Gly Ile Phe Asp Ser Leu Asn Leu Gly His 55 60 65 cag tct cac ttt aac cag agt att ctg aga gcc ctt gac ttt tct act 1855 Gln Ser His Phe Asn Gln Ser Ile Leu Arg Ala Leu Asp Phe Ser Thr 70 75 80 85 cct ggc aga act acc gcc gcg gta gcc ttt ttt gcc ttt atc ctt gac 1903 Pro Gly Arg Thr Thr Ala Ala Val Ala Phe Phe Ala Phe Ile Leu Asp 90 95 100 aaa tgg agt caa gaa acc cat ttc agc agg gat tac cgt ctg gac tgc 1951 Lys Trp Ser Gln Glu Thr His Phe Ser Arg Asp Tyr Arg Leu Asp Cys 105 110 115 tta gca gta gct ttg tgg aga aca tgg agg tgc cag cgc ctg aat gca 1999 Leu Ala Val Ala Leu Trp Arg Thr Trp Arg Cys Gln Arg Leu Asn Ala 120 125 130 atc tcc ggc tac ttg cca gta cag ccg gta gac acg ctg agg atc ctg 2047 Ile Ser Gly Tyr Leu Pro Val Gln Pro Val Asp Thr Leu Arg Ile Leu 135 140 145 agt ctc cag tca ccc cag gaa cac caa cgc cgc cag cag ccg cag cag 2095 Ser Leu Gln Ser Pro Gln Glu His Gln Arg Arg Gln Gln Pro Gln Gln 150 155 160 165 gag cag cag caa gag gag gag gac cga gaa gag aac ccg aga gcc ggt 2143 Glu Gln Gln Gln Glu Glu Glu Asp Arg Glu Glu Asn Pro Arg Ala Gly 170 175 180 ctg gac cct ccg gtg gcg gag gag gag gag tagctgactt gtttcccgag 2193 Leu Asp Pro Pro Val Ala Glu Glu Glu Glu 185 190 ctgcgccggg tgctgactag gtcttccagt ggacgggaga gggggattaa gcgggagagg 2253 catgaggaga ctagccacag aactgaactg actgtcagtc tgatgagccg caggcgccca 2313 gaatcggtgt ggtggcatga ggttcagtcg cagggggtag atgaggtctc ggtgatgcat 2373 gagaaatatt ccctagaaca agtcaagact tgttggttgg agcccgagga tgattgggag 2433 gtagccatca ggaattatgc caagctggct ctgaggccag acaagaagta caagattacc 2493 aaactgatta atatcagaaa ttcctgctac atttcaggga atggggccga ggtggagatc 2553 agtacccagg agagggtggc tttcagatgc tgcatgatga atatgtaccc gggggtggtg 2613 ggcatggagg gagtcacctt tatgaacgcg aggttcaggg gtgatgggta taatggggtg 2673 gtctttatgg ccaacaccaa gctgacagtg cacggatgct ccttctttgg cttcaataac 2733 atgtgcatcg aggcctgggg cagtgtttca gtgaggggat gcagcttttc agccaactgg 2793 atgggggtcg tgggcagaac caagagcaag gtgtcagtga agaaatgcct gttcgagagg 2853 tgccacctgg gggtgatgag cgagggcgaa gccaaagtca aacactgcgc ctctaccgag 2913 acgggctgct ttgtgtgtat caagggcaat gcccaagtca agcataacat gatctgtggg 2973 gcctcggatg agcgcggcta ccagatgctg acctgcgccg gtgggaacag ccatatgctg 3033 gccaccgtgc atgtggcctc gcacccccgc aagacatggc ccgagttcga gcacaacgtc 3093 atgacccgct gcaatgtgca cctgggctcc cgccgaggca tgttcatgcc ataccagtgc 3153 aacatgcaat ttgtgaaggt gctgctggag cccgatgcca tgtccagagt gagcctggcg 3213 ggggtgtttg acatgaatgt ggagctgtgg aaaattctga gatatgatga atccaagacc 3273 aggtgccggg cctgcgaatg cggaggcaag cacgccaggc ttcagcccgt gtgtgtggag 3333 gtgacggagg acctgcgacc cgatcatttg gtgttgtcct gcaacgggac ggagttcggc 3393 tccagcgggg aagaatctga ctagagtgag tagtgtttgg gggcgggtgg gagcctgcat 3453 gaggggcaga atgactaaaa tctgtgtttt tctgtgcagc agcatgagcg gaagcgcctc 3513 ctttgaggga ggggtattca gcccttatct gacggggcgt ctcccctcct gggcgggagt 3573 gcgtcagaat gtgatgggat ctacggtgga cggccggccc gtgcagcccg cgaactcttc 3633 aaccctgacc tacgcgaccc tgagctcctc gtccgtggac gcagctgccg ccgcagctgc 3693 tgcttccgcc gccagcgccg tgcgcggaat ggccctgggc gccggctact acagctctct 3753 ggtggccaac tcgagttcca ccaataatcc cgccagcctg aacgaggaga agctgctgct 3813 gctgatggcc cagctcgagg ccctgaccca gcgcctgggc gagctgaccc agcaggtggc 3873 tcagctgcag gcggagacgc gggccgcggt tgccacggtg aaaaccaaat aaaaaatgaa 3933 tcaataaata aacggagacg gttgttgatt ttaacacaga gtcttgaatc tttatttgat 3993 ttttcgcgcg cggtaggccc tggaccaccg gtctcgatca ttgagcaccc ggtggatctt 4053 ttccaggacc cggtagaggt gggcttggat gttgaggtac atgggcatga gcccgtcccg 4113 ggggtggagg tagctccatt gcagggcctc gtgctcgggg gtggtgttgt aaatcaccca 4173 gtcatagcag gggcgcagtg cgtggtgctg cacgatgtcc ttgaggagga gactgatggc 4233 cacgggcagc cccttggtgt aggtgttgac gaacctgttg agctgggagg gatgcatgcg 4293 gggggagatg agatgcatct tggcctggat cttgagattg gcgatgttcc cgcccagatc 4353 ccgccggggg ttcatgttgt gcaggaccac cagcacggtg tatccggtgc acttggggaa 4413 tttgtcatgc aacttggaag ggaaggcgtg aaagaatttg gagacgccct tgtgaccgcc 4473 caggttttcc atgcactcat ccatgatgat ggcgatgggc ccgtgggcgg cggcctgggc 4533 aaagacgttt cgggggtcgg acacatcgta gttgtggtcc tgggtgagct cgtcataggc 4593 cattttaatg aatttggggc ggagggtgcc cgactggggg acgaaggtgc cttcgatccc 4653 gggggcgtag ttgccctcgc agatctgcat ctcccaggcc ttgagctcgg agggggggat 4713 catgtccacc tgcggggcga tgaaaaaaac ggtttccggg gcgggggaga tgagctgcgc 4773 cgaaagcagg ttccggagca gctgggactt gccgcagccg gtggggccgt agatgacccc 4833 gatgaccggc tgcaggtggt agttgaggga gagacagctg ccgtcctcgc gtaggagggg 4893 ggccacctcg ttcatcatct cgcgcacatg catgttctcg cgcacgagtt ccgccaggag 4953 gcgctcgccc cccagcgaga ggagctcttg cagcgaggcg aagtttttca gcggcttgag 5013 cccgtcggcc atgggcattt tggagagggt ctgttgcaag agttccagac ggtcccagag 5073 ctcggtgatg tgctctacgg catctcgatc cagcagacct cctcgtttcg cgggttggga 5133 cgactgcggg agtagggcac cagacgatgg gcgtccagcg cagccagggt ccggtccttc 5193 cagggtcgca gcgtccgcgt cagcgtggtc tccgtcacgg tgaaggggtg cgcgccgggc 5253 tgggcgcttg cgagggtgcg cttcaggctc atccggctgg tcgagaaccg ctcccgatcg 5313 gcgccctgcg cgtcggccag gtagcaattg accatgagtt cgtagttgag cgcctcggcc 5373 gcgtggcctt tggcgcggag cttacctttg gaagtctgcc cgcaggcggg acagaggagg 5433 gacttgaggg cgtagagctt gggggcgagg aagacggact cgggggcgta ggcgtccgcg 5493 ccgcagtggg cgcagacggt ctcgcactcc acaagccagg tgaggtcggg ctggtcgggg 5553 tcaaaaacca gttttccgcc gttctttttg atgcgtttct tacctttggt ctccatgagc 5613 tcgtgtcccc gctgggtgac aaagaggctg tccgtgtccc cgtagaccga ctttatgggc 5673 cggtcctcga gcggtgtgcc acggtcctcc tcgtagagga accccgccca ctccgagacg 5733 aaagcccggg tccaggccag cacgaaggag gccacgtggg acgggtagcg gtcgttgtcc 5793 accagcgggt ccactttctc cagggtatgc aaacacatgt ccccctcgtc cacatccagg 5853 aaggtgattg gcttgtaagt gtaggccacg tgaccggggg tcccggccgg gggggtataa 5913 aagggggcgg gcccctgctc gtcctcactg tcttccggat cgctgtccag gagcgccagc 5973 tgttggggta ggtattccct ctcgaaggcg ggcatgacct cggcactcag gttgtcagtt 6033 tctagaaacg aggaggattt gatattgacg gtgccgttgg agacgccttt catgagcccc 6093 tcgtccatct ggtcagaaaa gacgatcttt ttgttgtcga gcttggtggc gaaggagccg 6153 tagagggcgt tggagagcag cttggcgatg gagcgcatgg tctggttctt ttccttgtcg 6213 gcgcgctcct tggcggcgat gttgagctgc acgtactcgc gcgccacgca cttccattcg 6273 gggaagacgg tggtgagctc gtcgggcacg attctgaccc gccagccgcg gttgtgcagg 6333 gtgatgaggt ccacgctggt ggccacctcg ccgcgcaggg gctcgttggt ccagcagagg 6393 cgcccgccct tgcgcgagca gaaggggggc agcgggtcca gcatgagctc gtcggggggg 6453 tcggcgtcca cggtgaagat gccgggcagg agctcggggt cgaagtagct gatgcaggtg 6513 cccagatcgt ccagcgccgc ttgccagtcg cgcacggcca gcgcgcgctc gtaggggctg 6573 aggggcgtgc cccagggcat ggggtgcgtg agcgcggagg cgtacatgcc gcagatgtcg 6633 tagacgtaga ggggctcctc gaggacgccg atgtaggtgg ggtagcagcg ccccccgcgg 6693 atgctggcgc gcacgtagtc gtacagctcg tgcgagggcg cgaggagccc cgcgccgagg 6753 ttggagcgct gcggcttttc ggcgcggtag acgatctggc ggaagatggc gtgggagttg 6813 gaggagatgg tgggcctctg gaagatgttg aagtgggcgt ggggcaggcc gaccgagtcc 6873 ctgatgaagt gggcgtagga gtcctgcagc ttggcgacga gctcggcggt gacgaggacg 6933 tccagggcgc agtagtcgag ggtctcttgg atgatgtcgt acttgagctg gcccttctgc 6993 ttccacagct cgcggttgag aaggaactct tcgcggtcct tccagtactc ttcgaggggg 7053 aacccgtcct gatcggcacg gtaagagccc accatgtaga actggttgac ggccttgtag 7113 gcgcagcagc ccttctccac ggggagggcg taagcttgcg cggccttgcg cagggaggtg 7173 tgggtgaggg cgaaggtgtc gcgcaccatg accttgagga actggtgctt gaagtcgagg 7233 tcgtcgcagc cgccctgctc ccagagttgg aagtccgtgc gcttcttgta ggcggggttg 7293 ggcaaagcga aagtaacatc gttgaagagg atcttgcccg cgcggggcat gaagttgcga 7353 gtgatgcgga aaggctgggg cacctcggcc cggttgttga tgacctgggc ggcgaggacg 7413 atctcgtcga agccgttgat gttgtgcccg acgatgtaga gttccacgaa tcgcgggcgg 7473 cccttgacgt ggggcagctt cttgagctcg tcgtaggtga gctcggcggg gtcgctgagc 7533 ccgtgctgct caagggccca gtcggcgacg tgggggttgg cgctgaggaa ggaagtccag 7593 agatccacgg ccagggcggt ttgcaagcgg tcccggtact gacggaactg ctggcccacg 7653 gccatttttt cgggggtgat gcagtagaag gtgcgggggt cgccgtgcca gcggtcccac 7713 ttgagctgga gggcgaggtc gtgggcgagc tcgacgagcg gcgggtcccc ggagagtttc 7773 atgaccagca tgaaggggac gagctgcttg ccgaaggacc ccatccaggt gtaggtttcc 7833 acatcgtagg tgaggaagag cctttcggtg cgaggatgcg agccgatggg gaagaactgg 7893 atctcctgcc accagttgga ggaatggctg ttgatgtgat ggaagtagaa atgccgacgg 7953 cgcgccgagc actcgtgctt gtgtttatac aagcgtccgc agtgctcgca acgctgcacg 8013 ggatgcacgt gctgcacgag ctgtacctgg gttcctttga cgaggaattt cagtgggcag 8073 tggagcgctg gcggctgcat ctggtgctgt actacgtcct ggccatcggc gtggccatcg 8133 tctgcctcga tggtggtcat gctgacgagc ccgcgcggga ggcaggtcca gacctcggct 8193 cggacgggtc ggagagcgag gacgagggcg cgcaggccgg agctgtccag ggtcctgaga 8253 cgctgcggag tcaggtcagt gggcagcggc ggcgcgcggt tgacttgcag gagcttttcc 8313 agggcgcgcg ggaggtccag atggtacttg atctccacgg cgccgttggt ggcgacgtcc 8373 acggcttgca gggtcccgtg cccctggggc gccaccaccg tgccccgttt cttcttgggc 8433 gctggcgttg gcgctgcttc catgtcggtc agaagcggcg gcgaggacgc gcgccgggcg 8493 gcaggggcgg ctcggggccc ggaggcaggg gcggcagggg cacgtcggcg ccgcgcgcgg 8553 gcaggttctg gtactgcgcc cggagaagac tggcgtgagc gacgacgcga cggttgacgt 8613 cctggatctg acgcctctgg gtgaaggcca cgggacccgt gagtttgaac ctgaaagaga 8673 gttcgacaga atcaatctcg gtatcgttga cggcggcctg ccgcaggatc tcttgcacgt 8733 cgcccgagtt gtcctggtag gcgatctcgg tcatgaactg ctcgatctcc tcctcctgaa 8793 ggtctccgcg gccggcgcgc tcgacggtgg ccgcgaggtc gttggagatg cggcccatga 8853 gctgcgagaa ggcgttcatg ccggcctcgt tccagacgcg gctgtagacc acggatccgt 8913 cggggtcgcg cgcgcgcatg accacctggg cgaggttgag ctccacgtgg cgcgtgaaga 8973 ccgcgtagtt gcagaggcgc tggtagaggt agttgagcgt ggtggcgatg tgctcggtga 9033 cgaagaagta catgatccag cggcggagcg gcatctcgct gacgtcgccc agggcttcca 9093 agcgctccat ggcctcgtag aagtccacgg cgaagttgaa aaactgggag ttgcgcgccg 9153 agacggtcaa ctcctcctcc agaagacgga tgagctcggc gatggtggcg cgcacctcgc 9213 gctcgaaggc cccggggggc tcctcttcca tctcctcctc ttcttcctcc tccactaaca 9273 tctcttctac ttcctcctca ggaggcggcg gcgggggagg gggcctgcgt cgccggcggc 9333 gcacgggcag acggtcgatg aagcgctcga tggtctcccc gcgccggcga cgcatggtct 9393 cggtgacggc gcgcccgtcc tcgcggggcc gcagcgtgaa gacgccgccg cgcatctcca 9453 ggtggccgcc gggggggtct ccgttgggca gggagagggc gctgacgatg catcttatca 9513 attgacccgt agggactccg cgcaaggacc tgagcgtctc gagatccacg ggatccgaaa 9573 accgctgaac gaaggcttcg agccagtcgc agtcgcaagg taggctgagc ccggtttctt 9633 cttcggggat ttgctggtcg ggaggcgggc gggcgatgct gctggtgatg aagttgaagt 9693 aggcggtcct gagacggcgg atggtggcga ggagcaccag gtccttgggc ccggcttgct 9753 ggatgcgcag acggtcggcc atgccccagg cgtggtcctg acacctggcg aggtccttgt 9813 agtagtcctg catgagccgc tccacgggca cctcctcctc gcccgcgcgg ccgtgcatgc 9873 gcgtgagccc gaacccgcgc tggggctgga cgagcgccag gtcggcgacg acgcgctcgg 9933 cgaggatggc ctgctggatc tgggtgaggg tggtctggaa gtcgtcgaag tcgacgaagc 9993 ggtggtaggc tccggtgttg atggtgtagg agcagttggc catgacggac cagttgacgg 10053 tctggtggcc ggggcgcacg agctcgtggt acttgaggcg cgagtaggcg cgcgtgtcga 10113 agatgtagtc gttgcaggtg cgcacgaggt actggtatcc gacgaggaag tgaggcggcg 10173 gctggcggta gagcggccat cgctcggtgg cgggggcgcc gggcgcgagg tcttcgagca 10233 tgaggcggtg gtagccgtag atgtacctgg acatccaggt gatgccagcg gcggtggtgg 10293 aggcgcgcgg gaactcgcgg acgcggttcc agatgttgcg cagcggcagg aagtagttca 10353 tggtggccgc ggtctggccc gtgaggcgcg cgcagtcgtg gatgctctag acatacgggc 10413 aaaaacgaaa gcggtcagcg gctcgactcc gtggcctgga ggctaagcga acgggttggg 10473 ctgcgcgtgt accccggttc gagtccctgc tcgaatcagg ctggagccgc agctaacgtg 10533 gtactggcac tcccgtctcg acccaagcct gctaacgaaa cctccaggat acggaggcgg 10593 gtcgtttttt ggccttggtc actggtcatg aaaaactagt aagcgcggaa agcggccgcc 10653 cgcgatggct cgctgccgta gtctggagaa agaatcgcca gggttgcgtt gcggtgtgcc 10713 ccggttcgag cctcagcgct cggcgccggc cggattccgc ggctaacgtg ggcgtggctg 10773 ccccgtcgtt tccaagaccc cttagccagc cgacttctcc agttacggag cgagcccctc 10833 tttttcttgt gtttttgcca g atg cat ccc gta ctg cgg cag atg cgc ccc 10884 Met His Pro Val Leu Arg Gln Met Arg Pro 195 200 cac cct cca cct caa ccg ccc cta ccg cag cag cag caa cag ccg gcg 10932 His Pro Pro Pro Gln Pro Pro Leu Pro Gln Gln Gln Gln Gln Pro Ala 205 210 215 ctt ttg ccc ccg ccc cag cag cag cag cag cca gcc act acc gcg gcg 10980 Leu Leu Pro Pro Pro Gln Gln Gln Gln Gln Pro Ala Thr Thr Ala Ala 220 225 230 gcc gcc gtg agc gga gcc ggc gtt caa tat gac ctg gcc ttg gaa gag 11028 Ala Ala Val Ser Gly Ala Gly Val Gln Tyr Asp Leu Ala Leu Glu Glu 235 240 245 ggc gag ggg ctg gcg cgg ctg ggg gcg tcg tcg ccg gag cgg cac ccg 11076 Gly Glu Gly Leu Ala Arg Leu Gly Ala Ser Ser Pro Glu Arg His Pro 250 255 260 265 cgc gtg cag atg aaa agg gac gct cgc gag gcc tac gtg ccc aag cag 11124 Arg Val Gln Met Lys Arg Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln 270 275 280 aac ctg ttc aga gac agg agc ggc gag gag ccc gag gag atg cgc gcc 11172 Asn Leu Phe Arg Asp Arg Ser Gly Glu Glu Pro Glu Glu Met Arg Ala 285 290 295 tcc cgc ttc cac gcg ggg cgg gag ctg cgg cgc ggc ctg gac cga aag 11220 Ser Arg Phe His Ala Gly Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys 300 305 310 cgg gtg ctg agg gac gag gat ttc gag gcg gac gag ctg acg ggg atc 11268 Arg Val Leu Arg Asp Glu Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile 315 320 325 agc ccc gcg cgc gcg cac gtg gcc gcg gcc aac ctg gtc acg gcg tac 11316 Ser Pro Ala Arg Ala His Val Ala Ala Ala Asn Leu Val Thr Ala Tyr 330 335 340 345 gag cag acc gtg aag gag gag agc aac ttc caa aaa tcc ttc aac aac 11364 Glu Gln Thr Val Lys Glu Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn 350 355 360 cac gtg cgc acg ctg atc gcg cgc gag gag gtg acc ctg ggc ctg atg 11412 His Val Arg Thr Leu Ile Ala Arg Glu Glu Val Thr Leu Gly Leu Met 365 370 375 cac ctg tgg gac ctg ctg gag gcc atc gtg cag aac ccc acg agc aag 11460 His Leu Trp Asp Leu Leu Glu Ala Ile Val Gln Asn Pro Thr Ser Lys 380 385 390 ccg ctg acg gcg cag ctg ttc ctg gtg gtg cag cac agt cgg gac aac 11508 Pro Leu Thr Ala Gln Leu Phe Leu Val Val Gln His Ser Arg Asp Asn 395 400 405 gag acg ttc agg gag gcg ctg ctg aat atc acc gag ccc gag ggc cgc 11556 Glu Thr Phe Arg Glu Ala Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg 410 415 420 425 tgg ctc ctg gac ctg gtg aac att ctg cag agc atc gtg gtg cag gag 11604 Trp Leu Leu Asp Leu Val Asn Ile Leu Gln Ser Ile Val Val Gln Glu 430 435 440 cgc ggg ctg ccg ctg tcc gag aag ctg gcg gcc atc aac ttc tcg gtg 11652 Arg Gly Leu Pro Leu Ser Glu Lys Leu Ala Ala Ile Asn Phe Ser Val 445 450 455 ctg agc ctg ggc aag tac tac gct agg aag atc tac aag acc ccg tac 11700 Leu Ser Leu Gly Lys Tyr Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr 460 465 470 gtg ccc ata gac aag gag gtg aag atc gat ggg ttt tac atg cgc atg 11748 Val Pro Ile Asp Lys Glu Val Lys Ile Asp Gly Phe Tyr Met Arg Met 475 480 485 acc ctg aaa gtg ctg acc ctg agc gac gat ctg ggg gtg tac cgc aac 11796 Thr Leu Lys Val Leu Thr Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn 490 495 500 505 gac agg atg cac cgc gcg gtg agc gcc agc cgc cgg cgc gag ctg agc 11844 Asp Arg Met His Arg Ala Val Ser Ala Ser Arg Arg Arg Glu Leu Ser 510 515 520 gac cag gag ctg atg cac agc ctg cag cgg gcc ctg acc ggg gcc ggg 11892 Asp Gln Glu Leu Met His Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly 525 530 535 acc gag ggg gag agc tac ttt gac atg ggc gcg gac ctg cgc tgg cag 11940 Thr Glu Gly Glu Ser Tyr Phe Asp Met Gly Ala Asp Leu Arg Trp Gln 540 545 550 ccc agc cgc cgg gcc ttg gaa gct gcc ggc ggc gtg ccc tac gtg gag 11988 Pro Ser Arg Arg Ala Leu Glu Ala Ala Gly Gly Val Pro Tyr Val Glu 555 560 565 gag gtg gac gat gag gag gag gag ggc gag tac ctg gaa gac 12030 Glu Val Asp Asp Glu Glu Glu Glu Gly Glu Tyr Leu Glu Asp 570 575 580 tgatggcgcg accgtatttt tgctag atg cag caa cag cca ccg cct cct gat 12083 Met Gln Gln Gln Pro Pro Pro Pro Asp 585 590 ccc gcg atg cgg gcg gcg ctg cag agc cag ccg tcc ggc att aac tcc 12131 Pro Ala Met Arg Ala Ala Leu Gln Ser Gln Pro Ser Gly Ile Asn Ser 595 600 605 tcg gac gat tgg acc cag gcc atg caa cgc atc atg gcg ctg acg acc 12179 Ser Asp Asp Trp Thr Gln Ala Met Gln Arg Ile Met Ala Leu Thr Thr 610 615 620 cgc aat ccc gaa gcc ttt aga cag cag cct cag gcc aac cgg ctc tcg 12227 Arg Asn Pro Glu Ala Phe Arg Gln Gln Pro Gln Ala Asn Arg Leu Ser 625 630 635 640 gcc atc ctg gag gcc gtg gtg ccc tcg cgc tcg aac ccc acg cac gag 12275 Ala Ile Leu Glu Ala Val Val Pro Ser Arg Ser Asn Pro Thr His Glu 645 650 655 aag gtg ctg gcc atc gtg aac gcg ctg gtg gag aac aag gcc atc cgc 12323 Lys Val Leu Ala Ile Val Asn Ala Leu Val Glu Asn Lys Ala Ile Arg 660 665 670 ggc gac gag gcc ggg ctg gtg tac aac gcg ctg ctg gag cgc gtg gcc 12371 Gly Asp Glu Ala Gly Leu Val Tyr Asn Ala Leu Leu Glu Arg Val Ala 675 680 685 cgc tac aac agc acc aac gtg cag acg aac ctg gac cgc atg gtg acc 12419 Arg Tyr Asn Ser Thr Asn Val Gln Thr Asn Leu Asp Arg Met Val Thr 690 695 700 gac gtg cgc gag gcg gtg tcg cag cgc gag cgg ttc cac cgc gag tcg 12467 Asp Val Arg Glu Ala Val Ser Gln Arg Glu Arg Phe His Arg Glu Ser 705 710 715 720 aac ctg ggc tcc atg gtg gcg ctg aac gcc ttc ctg agc acg cag ccc 12515 Asn Leu Gly Ser Met Val Ala Leu Asn Ala Phe Leu Ser Thr Gln Pro 725 730 735 gcc aac gtg ccc cgg ggc cag gag gac tac acc aac ttc atc agc gcg 12563 Ala Asn Val Pro Arg Gly Gln Glu Asp Tyr Thr Asn Phe Ile Ser Ala 740 745 750 ctg cgg ctg atg gtg gcc gag gtg ccc cag agc gag gtg tac cag tcg 12611 Leu Arg Leu Met Val Ala Glu Val Pro Gln Ser Glu Val Tyr Gln Ser 755 760 765 ggg ccg gac tac ttc ttc cag acc agt cgc cag ggc ttg cag acc gtg 12659 Gly Pro Asp Tyr Phe Phe Gln Thr Ser Arg Gln Gly Leu Gln Thr Val 770 775 780 aac ctg agc cag gct ttc aag aac ttg cag gga ctg tgg ggc gtg cag 12707 Asn Leu Ser Gln Ala Phe Lys Asn Leu Gln Gly Leu Trp Gly Val Gln 785 790 795 800 gcc ccg gtc ggg gac cgc gcg acg gtg tcg agc ctg ctg acg ccg aac 12755 Ala Pro Val Gly Asp Arg Ala Thr Val Ser Ser Leu Leu Thr Pro Asn 805 810 815 tcg cgc ctg ctg ctg ctg ctg gtg gcg ccc ttc acg gac agc ggc agc 12803 Ser Arg Leu Leu Leu Leu Leu Val Ala Pro Phe Thr Asp Ser Gly Ser 820 825 830 gtg agc cgc gac tcg tac ctg ggc tac ctg ctt aac ctg tac cgc gag 12851 Val Ser Arg Asp Ser Tyr Leu Gly Tyr Leu Leu Asn Leu Tyr Arg Glu 835 840 845 gcc atc ggg cag gcg cac gtg gac gag cag acc tac cag gag atc acc 12899 Ala Ile Gly Gln Ala His Val Asp Glu Gln Thr Tyr Gln Glu Ile Thr 850 855 860 cac gtg agc cgc gcg ctg ggc cag gag gac ccg ggc aac ctg gag gcc 12947 His Val Ser Arg Ala Leu Gly Gln Glu Asp Pro Gly Asn Leu Glu Ala 865 870 875 880 acc ctg aac ttc ctg ctg acc aac cgg tcg cag aag atc ccg ccc cag 12995 Thr Leu Asn Phe Leu Leu Thr Asn Arg Ser Gln Lys Ile Pro Pro Gln 885 890 895 tac gcg ctg agc acc gag gag gag cgc atc ctg cgc tac gtg cag cag 13043 Tyr Ala Leu Ser Thr Glu Glu Glu Arg Ile Leu Arg Tyr Val Gln Gln 900 905 910 agc gtg ggg ctg ttc ctg atg cag gag ggg gcc acg ccc agc gcc gcg 13091 Ser Val Gly Leu Phe Leu Met Gln Glu Gly Ala Thr Pro Ser Ala Ala 915 920 925 ctc gac atg acc gcg cgc aac atg gag ccc agc atg tac gcc cgc aac 13139 Leu Asp Met Thr Ala Arg Asn Met Glu Pro Ser Met Tyr Ala Arg Asn 930 935 940 cgc ccg ttc atc aat aag ctg atg gac tac ttg cat cgg gcg gcc gcc 13187 Arg Pro Phe Ile Asn Lys Leu Met Asp Tyr Leu His Arg Ala Ala Ala 945 950 955 960 atg aac tcg gac tac ttt acc aac gcc atc ttg aac ccg cac tgg ctc 13235 Met Asn Ser Asp Tyr Phe Thr Asn Ala Ile Leu Asn Pro His Trp Leu 965 970 975 ccg ccg ccc ggg ttc tac acg ggc gag tac gac atg ccc gac ccc aac 13283 Pro Pro Pro Gly Phe Tyr Thr Gly Glu Tyr Asp Met Pro Asp Pro Asn 980 985 990 gac ggg ttc ctg tgg gac gac gtg gac agc agc gtg ttc tcg ccg cgc 13331 Asp Gly Phe Leu Trp Asp Asp Val Asp Ser Ser Val Phe Ser Pro Arg 995 1000 1005 ccc acc acc acc gtg tgg aag aaa gag ggc ggg gac cgg cgg ccg 13376 Pro Thr Thr Thr Val Trp Lys Lys Glu Gly Gly Asp Arg Arg Pro 1010 1015 1020 tcc tcg gcg ctg tcc ggt cgc gcg ggt gct gcc gcg gcg gtg ccc 13421 Ser Ser Ala Leu Ser Gly Arg Ala Gly Ala Ala Ala Ala Val Pro 1025 1030 1035 gag gcc gcc agc ccc ttc ccg agc ctg ccc ttt tcg ctg aac agc 13466 Glu Ala Ala Ser Pro Phe Pro Ser Leu Pro Phe Ser Leu Asn Ser 1040 1045 1050 gtg cgc agc agc gat ctg ggt cgg ctg acg cgg ccg cgc ctg ctg 13511 Val Arg Ser Ser Asp Leu Gly Arg Leu Thr Arg Pro Arg Leu Leu 1055 1060 1065 ggc gag gag gag tac ctg aac gac tcc ttg ttg agg ccc gag cgc 13556 Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu Arg Pro Glu Arg 1070 1075 1080 gag aaa aac ttc ccc aat aac ggg ata gag agc ctg gtg gac aag 13601 Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu Val Asp Lys 1085 1090 1095 atg agc cgc tgg aag acg tac gcg cac gag cac agg gac gag ccc 13646 Met Ser Arg Trp Lys Thr Tyr Ala His Glu His Arg Asp Glu Pro 1100 1105 1110 cga gct agc agc agc acc ggc gcc cgt aga cgc cag cgg cac gac 13691 Arg Ala Ser Ser Ser Thr Gly Ala Arg Arg Arg Gln Arg His Asp 1115 1120 1125 agg cag cgg gga ctg gtg tgg gac gat gag gat tcc gcc gac gac 13736 Arg Gln Arg Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp Asp 1130 1135 1140 agc agc gtg ttg gac ttg ggt ggg agt ggt ggt ggt aac ccg ttc 13781 Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe 1145 1150 1155 gct cac ctg cgc ccc cgt atc ggg cgc ctg atg taagaatctg 13824 Ala His Leu Arg Pro Arg Ile Gly Arg Leu Met 1160 1165 aaaaaataaa aaaacggtac tcaccaaggc catggcgacc agcgtgcgtt cttctctgtt 13884 gtttgtagta gt atg atg agg cgc gtg tac ccg gag ggt cct cct ccc 13932 Met Met Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro 1170 1175 1180 tcg tac gag agc gtg atg cag cag gcg gtg gcg gcg gcg atg cag 13977 Ser Tyr Glu Ser Val Met Gln Gln Ala Val Ala Ala Ala Met Gln 1185 1190 1195 ccc ccg ctg gag gcg cct tac gtg ccc ccg cgg tac ctg gcg cct 14022 Pro Pro Leu Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro 1200 1205 1210 acg gag ggg cgg aac agc att cgt tac tcg gag ctg gca ccc ttg 14067 Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu 1215 1220 1225 tac gat acc acc cgg ttg tac ctg gtg gac aac aag tcg gcg gac 14112 Tyr Asp Thr Thr Arg Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp 1230 1235 1240 atc gcc tcg ctg aac tac cag aac gac cac agc aac ttc ctg acc 14157 Ile Ala Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr 1245 1250 1255 acc gtg gtg cag aac aac gat ttc acc ccc acg gag gcc agc acc 14202 Thr Val Val Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr 1260 1265 1270 cag acc atc aac ttt gac gag cgc tcg cgg tgg ggc ggc cag ctg 14247 Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu 1275 1280 1285 aaa acc atc atg cac acc aac atg ccc aac gtg aac gag ttc atg 14292 Lys Thr Ile Met His Thr Asn Met Pro Asn Val Asn Glu Phe Met 1290 1295 1300 tac agc aac aag ttc aag gcg cgg gtg atg gtc tcg cgc aag acc 14337 Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser Arg Lys Thr 1305 1310 1315 ccc aac ggg gtc aca gta aca gat ggt agt cag gac gag ctg acc 14382 Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln Asp Glu Leu Thr 1320 1325 1330 tac gag tgg gtg gag ttt gag ctg ccc gag ggc aac ttc tcg gtg 14427 Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn Phe Ser Val 1335 1340 1345 acc atg acc atc gat ctg atg aac aac gcc atc atc gac aac tac 14472 Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr 1350 1355 1360 ttg gcg gtg gga cgg cag aac ggg gtg ctg gag agc gac atc ggc 14517 Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly 1365 1370 1375 gtg aag ttc gac acg cgc aac ttc cgg ctg ggc tgg gac ccc gtg 14562 Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val 1380 1385 1390 acc gag ctg gtg atg ccg ggc gtg tac acc aac gag gcc ttc cac 14607 Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His 1395 1400 1405 ccc gac atc gtc ctg ctg ccc ggc tgc ggc gtg gac ttc acc gag 14652 Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu 1410 1415 1420 agc cgc ctc agc aac ctg ctg ggc atc cgc aag cgg cag ccc ttc 14697 Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe 1425 1430 1435 cag gag ggc ttc cag atc ctg tac gag gac ctg gag ggg ggc aac 14742 Gln Glu Gly Phe Gln Ile Leu Tyr Glu Asp Leu Glu Gly Gly Asn 1440 1445 1450 atc ccc gcg ctg ctg gac gtc gaa gcc tac gag aaa agc aag gag 14787 Ile Pro Ala Leu Leu Asp Val Glu Ala Tyr Glu Lys Ser Lys Glu 1455 1460 1465 gag gcc gcc gca gcg gcg acc gcg gcc gtg gct acc gct gcg acc 14832 Glu Ala Ala Ala Ala Ala Thr Ala Ala Val Ala Thr Ala Ala Thr 1470 1475 1480 acc gat gca gat gca gct act act acc agg ggc gat aca ttc gcc 14877 Thr Asp Ala Asp Ala Ala Thr Thr Thr Arg Gly Asp Thr Phe Ala 1485 1490 1495 acc cag gcg gag gaa gca gcc gcc cta gcg gcg acc gat gat agt 14922 Thr Gln Ala Glu Glu Ala Ala Ala Leu Ala Ala Thr Asp Asp Ser 1500 1505 1510 gaa agt aag ata gtc atc aag ccg gtg gag aag gac agc aag gac 14967 Glu Ser Lys Ile Val Ile Lys Pro Val Glu Lys Asp Ser Lys Asp 1515 1520 1525 agg agc tac aac gtt cta tcg gat gga aag aac acc gcc tac cgc 15012 Arg Ser Tyr Asn Val Leu Ser Asp Gly Lys Asn Thr Ala Tyr Arg 1530 1535 1540 agc tgg tac ctg gcc tac aac tac ggc gac cct gag aag ggc gtg 15057 Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly Asp Pro Glu Lys Gly Val 1545 1550 1555 cgc tcc tgg acg ctg ctc acc acc tcg gac gtc acc tgc ggc gtg 15102 Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp Val Thr Cys Gly Val 1560 1565 1570 gag caa gtc tac tgg tcg ctg ccc gac atg atg caa gac ccg gtc 15147 Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met Gln Asp Pro Val 1575 1580 1585 acc ttc cgc tcc acg cgt caa gtt agc aac tac ccg gtg gtg ggc 15192 Thr Phe Arg Ser Thr Arg Gln Val Ser Asn Tyr Pro Val Val Gly 1590 1595 1600 gcc gag ctc ctg ccc gtc tac tcc aag agc ttc ttc aac gag cag 15237 Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser Phe Phe Asn Glu Gln 1605 1610 1615 gcc gtc tac tcg cag cag ctg cgc gcc ttc acc tcg ctc acg cac 15282 Ala Val Tyr Ser Gln Gln Leu Arg Ala Phe Thr Ser Leu Thr His 1620 1625 1630 gtc ttc aac cgc ttc ccc gag aac cag atc ctc gtc cgc ccg ccc 15327 Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Val Arg Pro Pro 1635 1640 1645 gcg ccc acc att acc acc gtc agt gaa aac gtt cct gct ctc aca 15372 Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr 1650 1655 1660 gat cac ggg acc ctg ccg ctg cgc agc agt atc cgg gga gtc cag 15417 Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln 1665 1670 1675 cgc gtg acc gtc act gac gcc aga cgc cgc acc tgc ccc tac gtc 15462 Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val 1680 1685 1690 tac aag gcc ctg ggc gta gtc gcg ccg cgc gtc ctc tcg agc cgc 15507 Tyr Lys Ala Leu Gly Val Val Ala Pro Arg Val Leu Ser Ser Arg 1695 1700 1705 acc ttc taaaaa atg tcc att ctc atc tcg ccc agt aat aac acc ggt 15555 Thr Phe Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly 1710 1715 1720 tgg ggc ctg cgc gcg ccc agc aag atg tac gga ggc gct cgc caa 15600 Trp Gly Leu Arg Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln 1725 1730 1735 cgc tcc acg caa cac ccc gtg cgc gtg cgc ggg cac ttc cgc gct 15645 Arg Ser Thr Gln His Pro Val Arg Val Arg Gly His Phe Arg Ala 1740 1745 1750 ccc tgg ggc gcc ctc aag ggc cgc gtg cgc tcg cgc acc acc gtc 15690 Pro Trp Gly Ala Leu Lys Gly Arg Val Arg Ser Arg Thr Thr Val 1755 1760 1765 gac gac gtg atc gac cag gtg gtg gcc gac gcg cgc aac tac acg 15735 Asp Asp Val Ile Asp Gln Val Val Ala Asp Ala Arg Asn Tyr Thr 1770 1775 1780 ccc gcc gcc gcg ccc gcc tcc acc gtg gac gcc gtc atc gac agc 15780 Pro Ala Ala Ala Pro Ala Ser Thr Val Asp Ala Val Ile Asp Ser 1785 1790 1795 gtg gtg gcc gac gcg cgc cgg tac gcc cgc gcc aag agc cgg cgg 15825 Val Val Ala Asp Ala Arg Arg Tyr Ala Arg Ala Lys Ser Arg Arg 1800 1805 1810 cgg cgc atc gcc cgg cgg cac cgg agc acc ccc gcc atg cgc gcg 15870 Arg Arg Ile Ala Arg Arg His Arg Ser Thr Pro Ala Met Arg Ala 1815 1820 1825 gcg cga gcc ttg ctg cgc agg gcc agg cgc acg gga cgc agg gcc 15915 Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr Gly Arg Arg Ala 1830 1835 1840 atg ctc agg gcg gcc aga cgc gcg gcc tcc ggc agc agc agc gcc 15960 Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ser Ser Ser Ala 1845 1850 1855 ggc agg acc cgc aga cgc gcg gcc acg gcg gcg gcg gcg gcc atc 16005 Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala Ala Ile 1860 1865 1870 gcc agc atg tcc cgc ccg cgg cgc ggc aac gtg tac tgg gtg cgc 16050 Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val Arg 1875 1880 1885 gac gcc gcc acc ggt gtg cgc gtg ccc gtg cgc acc cgc ccc cct 16095 Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro 1890 1895 1900 cgc act tgaagatgct gacttcgcga tgttgatgtg tcccagcggc gaggagg atg 16151 Arg Thr Met tcc aag cgc aaa ttc aag gaa gag atg ctc cag gtc atc gcg cct 16196 Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1905 1910 1915 gag atc tac ggc ccc gcg gcg gcg gtg aag gag gaa aga aag ccc 16241 Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys Glu Glu Arg Lys Pro 1920 1925 1930 cgc aaa ctg aag cgg gtc aaa aag gac aaa aag gag gag gaa gat 16286 Arg Lys Leu Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Glu Asp 1935 1940 1945 gac gga ctg gtg gag ttt gtg cgc gag ttc gcc ccc cgg cgg cgc 16331 Asp Gly Leu Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg 1950 1955 1960 gtg cag tgg cgc ggg cgg aaa gtg aaa ccg gtg ctg cgg ccc ggc 16376 Val Gln Trp Arg Gly Arg Lys Val Lys Pro Val Leu Arg Pro Gly 1965 1970 1975 acc acg gtg gtc ttc acg ccc ggc gag cgt tcc ggc tcc gcc tcc 16421 Thr Thr Val Val Phe Thr Pro Gly Glu Arg Ser Gly Ser Ala Ser 1980 1985 1990 aag cgc tcc tac gac gag gtg tac ggg gac gag gac atc ctc gag 16466 Lys Arg Ser Tyr Asp Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu 1995 2000 2005 cag gcg gca gag cgt ctg ggc gag ttt gct tac ggc aag cgc agc 16511 Gln Ala Ala Glu Arg Leu Gly Glu Phe Ala Tyr Gly Lys Arg Ser 2010 2015 2020 cgc ccc gcg ccc ttg aaa gag gag gcg gtg tcc atc ccg ctg gac 16556 Arg Pro Ala Pro Leu Lys Glu Glu Ala Val Ser Ile Pro Leu Asp 2025 2030 2035 cac ggc aac ccc acg ccg agc ctg aag ccg gtg acc ctg cag cag 16601 His Gly Asn Pro Thr Pro Ser Leu Lys Pro Val Thr Leu Gln Gln 2040 2045 2050 gtg ctg ccg agc gcg gcg ccg cgc cgg ggc ttc aag cgc gag ggc 16646 Val Leu Pro Ser Ala Ala Pro Arg Arg Gly Phe Lys Arg Glu Gly 2055 2060 2065 ggc gag gat ctg tac ccg acc atg cag ctg atg gtg ccc aag cgc 16691 Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met Val Pro Lys Arg 2070 2075 2080 cag aag ctg gag gac gtg ctg gag cac atg aag gtg gac ccc gag 16736 Gln Lys Leu Glu Asp Val Leu Glu His Met Lys Val Asp Pro Glu 2085 2090 2095 gtg cag ccc gag gtc aag gtg cgg ccc atc aag cag gtg gcc ccg 16781 Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln Val Ala Pro 2100 2105 2110 ggc ctg ggc gtg cag acc gtg gac atc aag atc ccc acg gag ccc 16826 Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr Glu Pro 2115 2120 2125 atg gaa acg cag acc gag ccc gtg aag ccc agc acc agc acc atg 16871 Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr Met 2130 2135 2140 gag gtg cag acg gat ccc tgg atg ccg gcg ccg gct tcc acc acc 16916 Glu Val Gln Thr Asp Pro Trp Met Pro Ala Pro Ala Ser Thr Thr 2145 2150 2155 act cgc cga aga cgc aag tac ggc gcg gcc agc ctg ctg atg ccc 16961 Thr Arg Arg Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro 2160 2165 2170 aac tac gcg ctg cat cct tcc atc atc ccc acg ccg ggc tac cgc 17006 Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg 2175 2180 2185 ggc acg cgc ttc tac cgc ggc tac agc agc cgc cgc aag acc acc 17051 Gly Thr Arg Phe Tyr Arg Gly Tyr Ser Ser Arg Arg Lys Thr Thr 2190 2195 2200 acc cgc cgc cgc cgt cgc cgc acc cgc cgc agc acc acc gcg act 17096 Thr Arg Arg Arg Arg Arg Arg Thr Arg Arg Ser Thr Thr Ala Thr 2205 2210 2215 tcc gcc gcc gcc ttg gtg cgg aga gtg tac cgc agc ggg cgt gag 17141 Ser Ala Ala Ala Leu Val Arg Arg Val Tyr Arg Ser Gly Arg Glu 2220 2225 2230 cct ctg acc ctg ccg cgc gcg cgc tac cac ccg agc atc gcc att 17186 Pro Leu Thr Leu Pro Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 2235 2240 2245 taactctgcc gtcgcctcct tgcagat atg gcc ctc aca tgc cgc ctc cgc 17237 Met Ala Leu Thr Cys Arg Leu Arg 2250 2255 gtc ccc att acg ggc tac cga gga aga aag ccg cgc cgt aga agg 17282 Val Pro Ile Thr Gly Tyr Arg Gly Arg Lys Pro Arg Arg Arg Arg 2260 2265 2270 ctg acg ggg aac ggg ctg cgt cgc cat cac cac cgg cgg cgg cgc 17327 Leu Thr Gly Asn Gly Leu Arg Arg His His His Arg Arg Arg Arg 2275 2280 2285 gcc atc agc aag cgg ttg ggg gga ggc ttc ctg ccc gcg ctg atc 17372 Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe Leu Pro Ala Leu Ile 2290 2295 2300 ccc atc atc gcc gcg gcg atc ggg gcg atc ccc ggc ata gct tcc 17417 Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro Gly Ile Ala Ser 2305 2310 2315 gtg gcg gtg cag gcc tct cag cgc cac tgagacacag cttggaaaat 17464 Val Ala Val Gln Ala Ser Gln Arg His 2320 2325 ttgtaataaa aaaatggact gacgctcctg gtcctgtgat gtgtgttttt ag atg gaa 17522 Met Glu gac atc aat ttt tcg tcc ctg gca ccg cga cac ggc acg cgg ccg 17567 Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg Pro 2330 2335 2340 ttt atg ggc acc tgg agc gac atc ggc aac agc caa ctg aac ggg 17612 Phe Met Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly 2345 2350 2355 ggc gcc ttc aat tgg agc agt ctc tgg agc ggg ctt aag aat ttc 17657 Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe 2360 2365 2370 ggg tcc acg ctc aaa acc tat ggc aac aag gcg tgg aac agc agc 17702 Gly Ser Thr Leu Lys Thr Tyr Gly Asn Lys Ala Trp Asn Ser Ser 2375 2380 2385 aca ggg cag gcg ctg agg gaa aag ctg aaa gag cag aac ttc cag 17747 Thr Gly Gln Ala Leu Arg Glu Lys Leu Lys Glu Gln Asn Phe Gln 2390 2395 2400 cag aag gtg gtc gat ggc ctg gcc tcg ggc atc aac ggg gtg gtg 17792 Gln Lys Val Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val 2405 2410 2415 gac ctg gcc aac cag gcc gtg cag aaa cag atc aac agc cgc ctg 17837 Asp Leu Ala Asn Gln Ala Val Gln Lys Gln Ile Asn Ser Arg Leu 2420 2425 2430 gac gcg gtc ccg ccc gcg ggg tcc gtg gag atg ccc cag gtg gag 17882 Asp Ala Val Pro Pro Ala Gly Ser Val Glu Met Pro Gln Val Glu 2435 2440 2445 gag gag ctg cct ccc ctg gac aag cgc ggc gac aag cga ccg cgt 17927 Glu Glu Leu Pro Pro Leu Asp Lys Arg Gly Asp Lys Arg Pro Arg 2450 2455 2460 ccc gac gcg gag gag acg ctg ctg acg cac acg gac gag ccg ccc 17972 Pro Asp Ala Glu Glu Thr Leu Leu Thr His Thr Asp Glu Pro Pro 2465 2470 2475 ccg tac gag gag gcg gtg aaa ctg ggt ctg ccc acc acg cgg ccc 18017 Pro Tyr Glu Glu Ala Val Lys Leu Gly Leu Pro Thr Thr Arg Pro 2480 2485 2490 atc gcg ccc ctg gcc acc ggg gtg ctg aaa ccc gag tct aag ccc 18062 Ile Ala Pro Leu Ala Thr Gly Val Leu Lys Pro Glu Ser Lys Pro 2495 2500 2505 gcg acc ctg gac ttg cct cct ccc ccg acc tcc cgc ccc tcc aca 18107 Ala Thr Leu Asp Leu Pro Pro Pro Pro Thr Ser Arg Pro Ser Thr 2510 2515 2520 gtg gct aag ccc ctg ccg ccg gtg gcc cgc gcg cga ccc ggg agc 18152 Val Ala Lys Pro Leu Pro Pro Val Ala Arg Ala Arg Pro Gly Ser 2525 2530 2535 cgc ccg cag gcg aac tgg cag agc act ctg aac agc atc gtg ggt 18197 Arg Pro Gln Ala Asn Trp Gln Ser Thr Leu Asn Ser Ile Val Gly 2540 2545 2550 ctg gga gtg cag agt gtg aag cgc cgc cgc tgc tat taaacatacc 18243 Leu Gly Val Gln Ser Val Lys Arg Arg Arg Cys Tyr 2555 2560 gtagcgctta acttgcttgt ctgtgtgtgt atgtattatg tcgccgccgc tgtccagaag 18303 gaggagtgaa gaggcgcgtc gccgagttgc aag atg gcc acc cca tcg atg 18354 Met Ala Thr Pro Ser Met 2565 2570 ctg ccc cag tgg gcg tac atg cac atc gcc gga cag gac gct tcg 18399 Leu Pro Gln Trp Ala Tyr Met His Ile Ala Gly Gln Asp Ala Ser 2575 2580 2585 gag tac ctg agt ccg ggt ctg gtg cag ttc gcc cgc gcc aca gac 18444 Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala Arg Ala Thr Asp 2590 2595 2600 acc tac ttc agt ctg ggg aac aag ttt agg aac ccc acg gtg gcg 18489 Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro Thr Val Ala 2605 2610 2615 ccc acg cac gat gtg acc acc gac cgc agc cag cgg ctg acg ctg 18534 Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu Thr Leu 2620 2625 2630 cgc ttc gtg ccc gtg gac cgc gag gac aac acc tac tcg tac aaa 18579 Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr Lys 2635 2640 2645 gtg cgc tac acg ctg gcc gtg ggc gac aac cgc gtg ctg gac atg 18624 Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 2650 2655 2660 gcc agc acc tac ttt gac atc cgc ggc gtg ctg gac cgg ggc cct 18669 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro 2665 2670 2675 agc ttc aaa ccc tac tcc ggc acc gcc tac aac agc ctg gcc ccc 18714 Ser Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro 2680 2685 2690 aag gga gct ccc aat tcc agt cag tgg gag cag acg gag aac ggg 18759 Lys Gly Ala Pro Asn Ser Ser Gln Trp Glu Gln Thr Glu Asn Gly 2695 2700 2705 ggc gga cag gct acg act aaa aca cac acc tat gga gtt gcc cca 18804 Gly Gly Gln Ala Thr Thr Lys Thr His Thr Tyr Gly Val Ala Pro 2710 2715 2720 atg ggt gga act aat att aca gtc gac gga cta caa att gga act 18849 Met Gly Gly Thr Asn Ile Thr Val Asp Gly Leu Gln Ile Gly Thr 2725 2730 2735 gac gct aca gct gat acg gaa aaa cca att tat gct gat aaa aca 18894 Asp Ala Thr Ala Asp Thr Glu Lys Pro Ile Tyr Ala Asp Lys Thr 2740 2745 2750 ttc caa cct gag cct cag ata gga gag gaa aac tgg caa gaa act 18939 Phe Gln Pro Glu Pro Gln Ile Gly Glu Glu Asn Trp Gln Glu Thr 2755 2760 2765 gaa agc ttt tat ggc ggt agg gct ctt aag aaa gac aca aac atg 18984 Glu Ser Phe Tyr Gly Gly Arg Ala Leu Lys Lys Asp Thr Asn Met 2770 2775 2780 aag cct tgt tat ggc tca ttt gcc aga cct acc aat gaa aag gga 19029 Lys Pro Cys Tyr Gly Ser Phe Ala Arg Pro Thr Asn Glu Lys Gly 2785 2790 2795 ggt caa gct aaa ctt aaa gtt gga gct gat ggg ctg ccg acc aaa 19074 Gly Gln Ala Lys Leu Lys Val Gly Ala Asp Gly Leu Pro Thr Lys 2800 2805 2810 gaa ttt gac ata gac cta gca ttc ttt gat act cct ggt ggc act 19119 Glu Phe Asp Ile Asp Leu Ala Phe Phe Asp Thr Pro Gly Gly Thr 2815 2820 2825 gtg acc gga ggt aca gag gag tat aaa gca gat att gtt atg tat 19164 Val Thr Gly Gly Thr Glu Glu Tyr Lys Ala Asp Ile Val Met Tyr 2830 2835 2840 acc gaa aac acg tat ctg gaa act cca gac aca cat gtg gtg tat 19209 Thr Glu Asn Thr Tyr Leu Glu Thr Pro Asp Thr His Val Val Tyr 2845 2850 2855 aaa cca ggc aag gat aac aca agt tct aaa att aac ctg gtc cag 19254 Lys Pro Gly Lys Asp Asn Thr Ser Ser Lys Ile Asn Leu Val Gln 2860 2865 2870 cag tct atg ccc aac agg ccc aac tac att ggg ttt agg gac aac 19299 Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn 2875 2880 2885 ttt att ggg ctc atg tat tac aac agc act ggc aat atg ggt gtg 19344 Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val 2890 2895 2900 ctg gcc ggt cag gct tct cag ttg aat gct gtg gtt gac ttg caa 19389 Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln 2905 2910 2915 gac aga aac act gaa ctg tct tac cag ctc ttg ctt gac tct ttg 19434 Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu 2920 2925 2930 ggt gac aga acc agg tat ttc agt atg tgg aat cag gcg gtg gac 19479 Gly Asp Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp 2935 2940 2945 agt tat gat cct gat gtg cgc att att gaa aac cat ggt gtg gaa 19524 Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu 2950 2955 2960 gat gaa ctt ccc aac tat tgc ttc ccc ctg gat ggg tct ggc act 19569 Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asp Gly Ser Gly Thr 2965 2970 2975 aac gcc gct tac caa ggt gtg aaa gta aaa aat ggt caa gat ggt 19614 Asn Ala Ala Tyr Gln Gly Val Lys Val Lys Asn Gly Gln Asp Gly 2980 2985 2990 gat gtt gag agc gaa tgg gaa aaa gat gat act gtc gca gct cga 19659 Asp Val Glu Ser Glu Trp Glu Lys Asp Asp Thr Val Ala Ala Arg 2995 3000 3005 aat caa tta tgc aag ggc aac att ttt gcc atg gag atc aat ctc 19704 Asn Gln Leu Cys Lys Gly Asn Ile Phe Ala Met Glu Ile Asn Leu 3010 3015 3020 cag gcc aac ctg tgg aga agt ttt ctc tac tcg aac gtg gcc ctg 19749 Gln Ala Asn Leu Trp Arg Ser Phe Leu Tyr Ser Asn Val Ala Leu 3025 3030 3035 tac ctg ccc gat tct tac aag tac acg ccg gcc aac atc acc ctg 19794 Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr Pro Ala Asn Ile Thr Leu 3040 3045 3050 ccc acc aac acc aac acc tac gat tac atg aac ggg aga gtg gtg 19839 Pro Thr Asn Thr Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val Val 3055 3060 3065 cct ccc tcg ctg gtg gac gcc tac atc aac atc ggg gcg cgc tgg 19884 Pro Pro Ser Leu Val Asp Ala Tyr Ile Asn Ile Gly Ala Arg Trp 3070 3075 3080 tcg ctg gac ccc atg gac aac gtc aat ccc ttc aac cac cat cgc 19929 Ser Leu Asp Pro Met Asp Asn Val Asn Pro Phe Asn His His Arg 3085 3090 3095 aac gcg ggg ctg cgc tac cgc tcc atg ctc ctg ggc aac ggg cgc 19974 Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg 3100 3105 3110 tac gtg ccc ttc cac atc cag gtg ccc cag aaa ttt ttc gcc att 20019 Tyr Val Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile 3115 3120 3125 aag agc ctc ctg ctc ctg ccc ggg tcc tac acc tac gag tgg aac 20064 Lys Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn 3130 3135 3140 ttc cgc aag gac gtc aac atg atc ctg cag agc tcc ctc ggc aac 20109 Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn 3145 3150 3155 gac ctg cgc acg gac ggg gcc tcc atc tcc ttc acc agc atc aac 20154 Asp Leu Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn 3160 3165 3170 ctc tac gcc acc ttc ttc ccc atg gcg cac aac acc gcc tcc acg 20199 Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr 3175 3180 3185 ctc gag gcc atg ctg cgc aac gac acc aac gac cag tcc ttc aac 20244 Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn 3190 3195 3200 gac tac ctc tcg gcg gcc aac atg ctc tac ccc atc ccg gcc aac 20289 Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn 3205 3210 3215 gcc acc aac gtg ccc atc tcc atc ccc tcg cgc aac tgg gcc gcc 20334 Ala Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala 3220 3225 3230 ttc cgc ggc tgg tcc ttc acg cgc ctc aag acc aag gag acg ccc 20379 Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro 3235 3240 3245 tcg ctg ggc tcc ggg ttc gac ccc tac ttc gtc tac tcg ggc tcc 20424 Ser Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser 3250 3255 3260 atc ccc tac ctc gac ggc acc ttc tac ctc aac cac acc ttc aag 20469 Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys 3265 3270 3275 aag gtc tcc atc acc ttc gac tcc tcc gtc agc tgg ccc ggc aac 20514 Lys Val Ser Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn 3280 3285 3290 gac cgg ctc ctg acg ccc aac gag ttc gaa atc aag cgc acc gtc 20559 Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val 3295 3300 3305 gac ggc gag ggc tac aac gtg gcc cag tgc aac atg acc aag gac 20604 Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp 3310 3315 3320 tgg ttc ctg gtc cag atg ctg gcc cac tac aac atc ggc tac cag 20649 Trp Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln 3325 3330 3335 ggc ttc tac gtg ccc gag ggc tac aag gac cgc atg tac tcc ttc 20694 Gly Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe 3340 3345 3350 ttc cgc aac ttc cag ccc atg agc cgc cag gtg gtg gac gag gtc 20739 Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Val 3355 3360 3365 aac tac aag gac tac cag gcc gtc acc ctg gcc tac cag cac aac 20784 Asn Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn 3370 3375 3380 aac tcg ggc ttc gtc ggc tac ctc gcg ccc acc atg cgc cag ggc 20829 Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly 3385 3390 3395 cag ccc tac ccc gcc aac tac ccg tac ccg ctc atc ggc aag agc 20874 Gln Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser 3400 3405 3410 gcc gtc acc agc gtc acc cag aaa aag ttc ctc tgc gac agg gtc 20919 Ala Val Thr Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val 3415 3420 3425 atg tgg cgc atc ccc ttc tcc agc aac ttc atg tcc atg ggc gcg 20964 Met Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala 3430 3435 3440 ctc acc gac ctc ggc cag aac atg ctc tat gcc aac tcc gcc cac 21009 Leu Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His 3445 3450 3455 gcg cta gac atg aat ttc gaa gtc gac ccc atg gat gag tcc acc 21054 Ala Leu Asp Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr 3460 3465 3470 ctt ctc tat gtt gtc ttc gaa gtc ttc gac gtc gtc cga gtg cac 21099 Leu Leu Tyr Val Val Phe Glu Val Phe Asp Val Val Arg Val His 3475 3480 3485 cag ccc cac cgc ggc gtc atc gag gcc gtc tac ctg cgc acc ccc 21144 Gln Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro 3490 3495 3500 ttc tcg gcc ggt aac gcc acc acc taagctcttg cttcttgcaa g atg gct 21195 Phe Ser Ala Gly Asn Ala Thr Thr Met Ala 3505 3510 gag ccc acg ggc tcc ggc gag cag gag ctc agg gcc atc atc cgc 21240 Glu Pro Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile Arg 3515 3520 3525 gac ctg ggc tgc ggg ccc tac ttc ctg ggc acc ttc gat aag cgc 21285 Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg 3530 3535 3540 ttc ccg gga ttc atg gcc ccg cac aag ctg gcc tgc gcc atc gtc 21330 Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val 3545 3550 3555 aac acg gcc ggc cgc gag acc ggg ggc gag cac tgg ctg gcc ttc 21375 Asn Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe 3560 3565 3570 gcc tgg aac ccg cgc tcg aac acc tgc tac ctc ttc gac ccc ttc 21420 Ala Trp Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe 3575 3580 3585 ggg ttc tcg gac gag cgc ctc aag cag atc tac cag ttc gag tac 21465 Gly Phe Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr 3590 3595 3600 gag ggc ctg ctg cgc cgc agc gcc ctg gcc acc gag gac cgc tgc 21510 Glu Gly Leu Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys 3605 3610 3615 gtc acc ctg gaa aag tcc acc cag acc gtg cag ggt ccg cgc tcg 21555 Val Thr Leu Glu Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser 3620 3625 3630 gcc gcc tgc ggg ctc ttt tgc tgc atg ttc ctg cac gcc ttc gtg 21600 Ala Ala Cys Gly Leu Phe Cys Cys Met Phe Leu His Ala Phe Val 3635 3640 3645 cac tgg ccc gac cgc ccc atg gac aag aac ccc acc atg aac ttg 21645 His Trp Pro Asp Arg Pro Met Asp Lys Asn Pro Thr Met Asn Leu 3650 3655 3660 ctg acg ggg gtg ccc aac ggc atg ctc cag tcg ccc cag gtg gaa 21690 Leu Thr Gly Val Pro Asn Gly Met Leu Gln Ser Pro Gln Val Glu 3665 3670 3675 ccc acc ctg cgc cgc aac cag gag gcg ctc tac cgc ttc ctc aac 21735 Pro Thr Leu Arg Arg Asn Gln Glu Ala Leu Tyr Arg Phe Leu Asn 3680 3685 3690 gcc cac tcc gcc tac ttt cgc tcc cac cgc gcg cgc atc gag aag 21780 Ala His Ser Ala Tyr Phe Arg Ser His Arg Ala Arg Ile Glu Lys 3695 3700 3705 gcc acc gcc ttc gac cgc atg aat caa gac atg taaaccgtgt 21823 Ala Thr Ala Phe Asp Arg Met Asn Gln Asp Met 3710 3715 gtgtgtatgt taaaatgtct ttaataaaca gcactttcat gttacacatg catctgagat 21883 gatttattta gaaatcgaaa gggttctgcc gggtctcggc atggcccgcg ggcagggaca 21943 cgttgcggaa ctggtacttg gccagccact tgaactcggg gatcagcagt ttcggcagcg 22003 gggtgtcggg gaaggagtcg gtccacagct tccgcgtcag ttgcagggcg cccagcaggt 22063 cgggcgcgga gatcttgaaa tcgcagttgg gacccgcgtt ctgcgcgcga gagttgcggt 22123 acacggggtt gcagcactgg aacaccatca gggccgggtg cttcacgctc gccagcaccg 22183 tcgcgtcggt gatgccctcc acgtccagat cctcggcgtt ggccatcccg aagggggtca 22243 tcttgcaggt ctgccgcccc atgctgggca cgcagccggg cttgtggttg caatcgcagt 22303 gcagggggat cagcatcatc tgggcctgct cggagctcat gcccgggtac atggccttca 22363 tgaaagcctc cagctggcgg aaggcctgct gcgccttgcc gccctcggtg aagaagaccc 22423 cgcaggactt gctagagaac tggttggtag cgcagcccgc gtcgtgcacg cagcagcgcg 22483 cgtcgttgtt ggccagctgc accacgctgc gcccccagcg gttctgggtg atcttggccc 22543 ggtcggggtt ctccttcagc gcgcgctgcc cgttctcgct cgccacatcc atctcgatcg 22603 tgtgctcctt ctggatcatc acggtcccgt gcaggcaccg cagcttgccc tcggcctcgg 22663 tgcagccgtg cagccacagc gcgcagccgg tgctctccca gttcttgtgg gcgatctggg 22723 agtgcgagtg cacgaagccc tgcaggaagc ggcccatcat cgcggtcagg gtcttgttgc 22783 tggtgaaggt cagcgggatg ccgcggtgct cctcgttcac atacaggtgg cagatgcggc 22843 ggtacacctc gccctgctcg ggcatcagct ggaaggcgga cttcaggtcg ctctccacgc 22903 ggtaccggtc catcagcagc gtcatcactt ccatgccctt ctcccaggcc gagacgatcg 22963 gcaggctcag ggggttcttc accgccattg tcatcttagt cgccgccgcc gaggtcaggg 23023 ggtcgttctc gtccagggtc tcaaacactc gcttgccgtc cttctcgatg atgcgcacgg 23083 ggggaaagct gaagcccacg gccgccagct cctcctcggc ctgcctttcg tcctcgctgt 23143 cctggctgat gtcttgcaaa ggcacatgct tggtcttgcg gggtttcttt ttgggcggca 23203 gaggcggcgg cgatgtgctg ggcgagcgcg agttctcgct caccacgact atttcttctc 23263 cttggccgtc gtccgagacc acgcggcggt aggcatgcct cttctggggc agaggcggag 23323 gcgacgggct ctcgcggttc ggcgggcggc tggcagagcc ccttccgcgt tcgggggtgc 23383 gctcctggcg gcgctgctct gactgacttc ctccgcggcc ggccattgtg ttctcctagg 23443 gagcaacaac aagc atg gag act cag cca tcg tcg cca aca tcg cca tct 23493 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser 3720 3725 gcc ccc gcc tcc acc gcc gac gag aac cag cag cag aat gaa agc 23538 Ala Pro Ala Ser Thr Ala Asp Glu Asn Gln Gln Gln Asn Glu Ser 3730 3735 3740 tta acc gcc ccg ccg ccc agc ccc acc tcc gac gcc gcg gcc cca 23583 Leu Thr Ala Pro Pro Pro Ser Pro Thr Ser Asp Ala Ala Ala Pro 3745 3750 3755 gac atg caa gag atg gag gaa tcc atc gag att gac ctg ggc tac 23628 Asp Met Gln Glu Met Glu Glu Ser Ile Glu Ile Asp Leu Gly Tyr 3760 3765 3770 gtg acg ccc gcg gag cac gag gag gag ctg gca gcg cgc ttt tca 23673 Val Thr Pro Ala Glu His Glu Glu Glu Leu Ala Ala Arg Phe Ser 3775 3780 3785 gcc ccg gaa gag aac cac caa gag cag cca gag cag gaa gca gag 23718 Ala Pro Glu Glu Asn His Gln Glu Gln Pro Glu Gln Glu Ala Glu 3790 3795 3800 aac gag cag aac cag gct ggg cac gag cat ggc gac tac ctg agc 23763 Asn Glu Gln Asn Gln Ala Gly His Glu His Gly Asp Tyr Leu Ser 3805 3810 3815 ggg gca gag gac gtg ctc atc aag cat ctg gcc cgc caa tgc atc 23808 Gly Ala Glu Asp Val Leu Ile Lys His Leu Ala Arg Gln Cys Ile 3820 3825 3830 atc gtc aag gac gcg ctg ctc gac cgc gcc gag gtg ccc ctc agc 23853 Ile Val Lys Asp Ala Leu Leu Asp Arg Ala Glu Val Pro Leu Ser 3835 3840 3845 gtg gcg gag ctc agc cgc gcc tac gag cgc aac ctc ttc tcg ccg 23898 Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg Asn Leu Phe Ser Pro 3850 3855 3860 cgc gtg ccc ccc aag cgc cag ccc aac ggc acc tgt gag ccc aac 23943 Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys Glu Pro Asn 3865 3870 3875 ccg cgc ctc aac ttc tac ccg gtc ttc gcg gtg ccc gag gcc ctg 23988 Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu Ala Leu 3880 3885 3890 gcc acc tac cac ctc ttt ttc aag aac caa aga atc ccc gtc tcc 24033 Ala Thr Tyr His Leu Phe Phe Lys Asn Gln Arg Ile Pro Val Ser 3895 3900 3905 tgc cgc gcc aac cgc acc cgc gcc gac gcc ctt ttc aac ctg ggc 24078 Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Phe Asn Leu Gly 3910 3915 3920 ccc ggc gcc cgc cta cct gat atc gcc tcc ttg gaa gag gtt ccc 24123 Pro Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro 3925 3930 3935 aag atc ttc gag ggt ctg ggc agc gac gag act cgg gcc gcg aac 24168 Lys Ile Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn 3940 3945 3950 gct ctg caa gga gaa gga gga gag cat gag cac cac agc gcc ctg 24213 Ala Leu Gln Gly Glu Gly Gly Glu His Glu His His Ser Ala Leu 3955 3960 3965 gtc gag ttg gaa ggc gac aac gcg cgg ctg gcg gtg ctc aaa cgc 24258 Val Glu Leu Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg 3970 3975 3980 acg gtc gag ctg acc cat ttc gcc tac ccg gct ctg aac ctg ccc 24303 Thr Val Glu Leu Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro 3985 3990 3995 ccc aaa gtc atg agc gcc gtc atg gac cag gtg ctc atc aag cgc 24348 Pro Lys Val Met Ser Ala Val Met Asp Gln Val Leu Ile Lys Arg 4000 4005 4010 gcg tcg ccc atc tcc gag gac gag ggc atg caa gac ccc gag agc 24393 Ala Ser Pro Ile Ser Glu Asp Glu Gly Met Gln Asp Pro Glu Ser 4015 4020 4025 acc gag gat ggc aag ccc gtg gtc agc gac gag cag ctg gcc cgg 24438 Thr Glu Asp Gly Lys Pro Val Val Ser Asp Glu Gln Leu Ala Arg 4030 4035 4040 tgg ctg ggt cct aat gct agt ccc cag agt ttg gaa gag cgg cgc 24483 Trp Leu Gly Pro Asn Ala Ser Pro Gln Ser Leu Glu Glu Arg Arg 4045 4050 4055 aag ctc atg atg gcc gtg gtc ctg gtg acc gtg gag ctg gag tgc 24528 Lys Leu Met Met Ala Val Val Leu Val Thr Val Glu Leu Glu Cys 4060 4065 4070 ctg cgc cgc ttc ttc gcc gac gcg gag acc ctg cgc aag gtc gag 24573 Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu Arg Lys Val Glu 4075 4080 4085 gag aac ctg cac tac ctc ttc agg cac ggg ttc gtg cgc cag gcc 24618 Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val Arg Gln Ala 4090 4095 4100 tgc aag atc tcc aac gtg gag ctg acc aac ctg gtc tcc tac atg 24663 Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr Met 4105 4110 4115 ggc atc ttg cac gag aac cgt ctg ggg cag aac gtg ctg cac acc 24708 Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr 4120 4125 4130 acc ctg cgc ggg gag gcc cgc cgc gac tac atc cgc gac tgc gtc 24753 Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val 4135 4140 4145 tac ctc tac ctc tgc cac acc tgg cag acg ggc atg ggc gtg tgg 24798 Tyr Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp 4150 4155 4160 cag cag tgc ctg gag gag cag aac ctg aaa gag ctc tgc aag ctc 24843 Gln Gln Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu 4165 4170 4175 ctg cag aag aac ctc aag ggt ctg tgg acc ggg ttc gac gag cgg 24888 Leu Gln Lys Asn Leu Lys Gly Leu Trp Thr Gly Phe Asp Glu Arg 4180 4185 4190 acc acc gcc tcg gat ctg gcc gac ctc atc ttc ccc gag cgc ctc 24933 Thr Thr Ala Ser Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu 4195 4200 4205 agg ctg acg ctg cgc aac ggc ctg ccc gac ttt atg agc caa agc 24978 Arg Leu Thr Leu Arg Asn Gly Leu Pro Asp Phe Met Ser Gln Ser 4210 4215 4220 atg ttg caa aac ttt cgc tct ttc atc ctc gaa cgc tcc gga atc 25023 Met Leu Gln Asn Phe Arg Ser Phe Ile Leu Glu Arg Ser Gly Ile 4225 4230 4235 ctg ccc gcc acc tgc tcc gcg ctg ccc tcg gac ttc gtg ccg ctg 25068 Leu Pro Ala Thr Cys Ser Ala Leu Pro Ser Asp Phe Val Pro Leu 4240 4245 4250 acc ttc cgc gag tgc ccc ccg ccg ctg tgg agc cac tgc tac ctg 25113 Thr Phe Arg Glu Cys Pro Pro Pro Leu Trp Ser His Cys Tyr Leu 4255 4260 4265 ctg cgc ctg gcc aac tac ctg gcc tac cac tcg gac gtg atc gag 25158 Leu Arg Leu Ala Asn Tyr Leu Ala Tyr His Ser Asp Val Ile Glu 4270 4275 4280 gac gtc agc ggc gag ggc ctg ctc gag tgc cac tgc cgc tgc aac 25203 Asp Val Ser Gly Glu Gly Leu Leu Glu Cys His Cys Arg Cys Asn 4285 4290 4295 ctc tgc acg ccg cac cgc tcc ctg gcc tgc aac ccc cag ctg ctg 25248 Leu Cys Thr Pro His Arg Ser Leu Ala Cys Asn Pro Gln Leu Leu 4300 4305 4310 agc gag acc cag atc atc ggc acc ttc gag ttg caa ggg ccc agc 25293 Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln Gly Pro Ser 4315 4320 4325 gat gag ggt tcc gcc gcc aag ggg ggt ctg aaa ctc acc ccg ggg 25338 Asp Glu Gly Ser Ala Ala Lys Gly Gly Leu Lys Leu Thr Pro Gly 4330 4335 4340 ctg tgg acc tcg gcc tac ttg cgc aag ttc gtg ccc gag gac tac 25383 Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr 4345 4350 4355 cat ccc ttc gag atc agg ttc tac gag gac caa tcc cag ccg ccc 25428 His Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro 4360 4365 4370 aag gcc gag ctg tcg gcc tgc gtc atc acc cag ggg gcg atc ctg 25473 Lys Ala Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu 4375 4380 4385 gcc caa ttg caa gcc atc cag aaa tcc cgc caa gaa ttc ttg ctg 25518 Ala Gln Leu Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu 4390 4395 4400 aaa aag ggc cgc ggg gtc tac ctc gac ccc cag acc ggt gag gag 25563 Lys Lys Gly Arg Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu 4405 4410 4415 ctc aac ccc ggc ttc ccc cag gat gcc ccg agg aaa caa gaa gct 25608 Leu Asn Pro Gly Phe Pro Gln Asp Ala Pro Arg Lys Gln Glu Ala 4420 4425 4430 gaa agt gga gct gcc gcc cgt gga gga ttt gga gga aga ctg gga 25653 Glu Ser Gly Ala Ala Ala Arg Gly Gly Phe Gly Gly Arg Leu Gly 4435 4440 4445 gaa cag cag tca ggc aga gga gga gga gat gga gga aga ctg gga 25698 Glu Gln Gln Ser Gly Arg Gly Gly Gly Asp Gly Gly Arg Leu Gly 4450 4455 4460 cag cac tca ggc aga gga gga cag cct gca aga cag tct gga gga 25743 Gln His Ser Gly Arg Gly Gly Gln Pro Ala Arg Gln Ser Gly Gly 4465 4470 4475 aga cga gga gga ggc aga ggt gga aga agc agc cgc cgc cag acc 25788 Arg Arg Gly Gly Gly Arg Gly Gly Arg Ser Ser Arg Arg Gln Thr 4480 4485 4490 gtc gtc ctc ggc ggg gga gaa agc aag cag cac gga tac cat ctc 25833 Val Val Leu Gly Gly Gly Glu Ser Lys Gln His Gly Tyr His Leu 4495 4500 4505 cgc tcc ggg tcg ggg tcc cgc tcg gcc cca cag tagatgggac 25876 Arg Ser Gly Ser Gly Ser Arg Ser Ala Pro Gln 4510 4515 gagaccgggc gattcccgaa ccccaccacc cagaccggta agaaggagcg gcagggatac 25936 aagtcctggc gggggcacaa aaacgccatc gtctcctgct tgcaggcctg cgggggcaac 25996 atctccttca cccggcgcta cctgctcttc caccgcgggg tgaacttccc ccgcaacatc 26056 ttgcattact accgtcacct ccacagcccc tactacttcc aagaagaggc agcagaaaaa 26116 gaccagaaaa ccagctagaa aatccacagc ggcggcagca ggtggactga ggatcgcggc 26176 gaacgagccg gcgcagaccc gggagctgag gaaccggatc tttcccaccc tctatgccat 26236 cttccagcag agtcgggggc aggagcagga actgaaagtc aagaaccgtt ctctgcgctc 26296 gctcacccgc agttgtctgt atcacaagag cgaagaccaa cttcagcgca ctctcgagga 26356 cgccgaggct ctcttcaaca agtactgcgc gctcactctt aaagagtagc ccgcgcccgc 26416 ccacacacgg aaaaaggcgg gaattacgtc accacctgcg cccttcgccc gaccatc 26473 atg agc aaa gag att ccc acg cct tac atg tgg agc tac cag ccc 26518 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro 4520 4525 4530 cag atg ggc ctg gcc gcc ggc gcc gcc cag gac tac tcc acc cgc 26563 Gln Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg 4535 4540 4545 atg aac tgg ctc agt gcc ggg ccc gcg atg atc tca cgg gtg aat 26608 Met Asn Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn 4550 4555 4560 gac atc cgc gcc cgc cga aac cag ata ctc cta gaa cag tca gcg 26653 Asp Ile Arg Ala Arg Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala 4565 4570 4575 atc gcc gcc acg ccc cgc cat cac ctt aat ccg cgt aat tgg ccc 26698 Ile Ala Ala Thr Pro Arg His His Leu Asn Pro Arg Asn Trp Pro 4580 4585 4590 gcc gcc ctg gtg tac cag gaa att ccc cag ccc acg acc gta cta 26743 Ala Ala Leu Val Tyr Gln Glu Ile Pro Gln Pro Thr Thr Val Leu 4595 4600 4605 ctt ccg cga gac gcc cag gcc gaa gtc cag ctg act aac tca ggt 26788 Leu Pro Arg Asp Ala Gln Ala Glu Val Gln Leu Thr Asn Ser Gly 4610 4615 4620 gtc cag ctg gcc ggc ggc gcc gcc ctg tgt cgt cac cgc ccc gct 26833 Val Gln Leu Ala Gly Gly Ala Ala Leu Cys Arg His Arg Pro Ala 4625 4630 4635 cag ggt ata aag cgg ctg gtg atc cga ggc aga ggc aca cag ctc 26878 Gln Gly Ile Lys Arg Leu Val Ile Arg Gly Arg Gly Thr Gln Leu 4640 4645 4650 aac gac gag gtg gtg agc tct tcg ctg ggt ctg cga cct gac gga 26923 Asn Asp Glu Val Val Ser Ser Ser Leu Gly Leu Arg Pro Asp Gly 4655 4660 4665 gtc ttc caa ctc gcc gga tcg ggg aga tct tcc ttc acg cct cgt 26968 Val Phe Gln Leu Ala Gly Ser Gly Arg Ser Ser Phe Thr Pro Arg 4670 4675 4680 cag gcc gtc ctg act ttg gag agt tcg tcc tcg cag ccc cgc tcg 27013 Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser Gln Pro Arg Ser 4685 4690 4695 ggc ggc atc ggc act ctc cag ttc gtg gag gag ttc act ccc tcg 27058 Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe Thr Pro Ser 4700 4705 4710 gtc tac ttc aac ccc ttc tcc ggc tcc ccc ggc cac tac ccg gac 27103 Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr Pro Asp 4715 4720 4725 gag ttc atc ccg aac ttc gac gcc atc agc gag tcg gtg gac ggc 27148 Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp Gly 4730 4735 4740 tac gat tga atg tcc cat ggt ggc gca gct gac cta gct cgg ctt 27193 Tyr Asp Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu 4745 4750 4755 cga cac ctg gac cac tgc cgc cgc ttc cgc tgc ttc gct cgg gat 27238 Arg His Leu Asp His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp 4760 4765 4770 ctc gcc gag ttt gcc tac ttt gag ctg ccc gag gag cac cct cag 27283 Leu Ala Glu Phe Ala Tyr Phe Glu Leu Pro Glu Glu His Pro Gln 4775 4780 4785 ggc cca gcc cac gga gtg cgg atc atc gtc gaa ggg ggc ctc gac 27328 Gly Pro Ala His Gly Val Arg Ile Ile Val Glu Gly Gly Leu Asp 4790 4795 4800 tcc cac ctg ctt cgg atc ttc agc cag cga ccg atc ctg gtc gag 27373 Ser His Leu Leu Arg Ile Phe Ser Gln Arg Pro Ile Leu Val Glu 4805 4810 4815 cgc gaa caa gga cag acc cgt ctg acc ctg tac tgc atc tgc aac 27418 Arg Glu Gln Gly Gln Thr Arg Leu Thr Leu Tyr Cys Ile Cys Asn 4820 4825 4830 cac ccc ggc ctg cat gaa agt ctt tgt tgt ctg ctg tgt act gag 27463 His Pro Gly Leu His Glu Ser Leu Cys Cys Leu Leu Cys Thr Glu 4835 4840 4845 tat aat aaa agc tgagatcagc gactactccg gactcgattg tggtgttcct 27515 Tyr Asn Lys Ser 4850 gctatcaacc ggtccctgtt cttcaccggg aacgaaaccg agctccagct ccagtgtaag 27575 ccccacaaga agtacctcac ctggctgttc cagggctccc ccatcgccgt tgtcaaccac 27635 tgcgacaacg acggagtcct gctgagcggc cctgccaacc ttactttttc cacccgcaga 27695 agcaagctcc agctcttcca acccttcctc cccgggacct atcagtgcgt ctcgggaccc 27755 tgccatcaca ccttccacct gatcccgaat accacagcgc cgctccccgc tactaacaac 27815 caaactaacc tccaccaacg ccaccgtcgc gacctttcct ctgaatctaa taccactacc 27875 ggaggtgagc tccgaggtcg accaacctct gggatttact acggcccctg ggaggtggtg 27935 gggttaatag cgctaggcct agttgtgggt gggcttttgg ctctctgcta cctatacctc 27995 ccttgctgtt cgtacttagt ggtgctgtgt tgctggttta agaa atg ggg cag atc 28051 Met Gly Gln Ile 4855 acc cta gtg agc tgc ggt gtg ctg gtg gcg gtg ctt tcg att gtg 28096 Thr Leu Val Ser Cys Gly Val Leu Val Ala Val Leu Ser Ile Val 4860 4865 4870 gga ctg ggc ggc gcg gct gta gtg aag gag gag aag gcc gat ccc 28141 Gly Leu Gly Gly Ala Ala Val Val Lys Glu Glu Lys Ala Asp Pro 4875 4880 4885 tgc ttg cat ttc aat ccc gac aaa tgc cag ctg agt ttt cag ccc 28186 Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe Gln Pro 4890 4895 4900 gat ggc aat cgg tgc gcg gtg ctg atc aag tgc gga tgg gaa tgc 28231 Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys 4905 4910 4915 gag aac gtg aga atc gag tac aat aac aag act cgg aac aat act 28276 Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr 4920 4925 4930 ctc gcg tcc gtg tgg cag ccc ggg gac ccc gag tgg tac acc gtc 28321 Leu Ala Ser Val Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val 4935 4940 4945 tct gtc ccc ggt gct gac ggc tcc ccg cgc acc gtg aat aat act 28366 Ser Val Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr 4950 4955 4960 ttc att ttt gcg cac atg tgc aac acg gtc atg tgg atg agc aag 28411 Phe Ile Phe Ala His Met Cys Asn Thr Val Met Trp Met Ser Lys 4965 4970 4975 cag tac gat atg tgg ccc ccc acg aag gag aac atc gtg gtc ttc 28456 Gln Tyr Asp Met Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe 4980 4985 4990 tcc atc gct tac agc ctg tgc acg gcg cta atc acc gct atc gtg 28501 Ser Ile Ala Tyr Ser Leu Cys Thr Ala Leu Ile Thr Ala Ile Val 4995 5000 5005 tgc ctg agc att cac atg ctc atc gct att cgc ccc aga aat aat 28546 Cys Leu Ser Ile His Met Leu Ile Ala Ile Arg Pro Arg Asn Asn 5010 5015 5020 gcc gag aaa gag aaa cag cca taacacgttt tttcacacac cttgttttta 28597 Ala Glu Lys Glu Lys Gln Pro 5025 cagaca atg cgt ctg tta aat ttt tta aac att gtg ctc agt att gct 28645 Met Arg Leu Leu Asn Phe Leu Asn Ile Val Leu Ser Ile Ala 5030 5035 5040 tat gcc tct ggt tat gca aac ata cag aaa acc ctt tat gta gga 28690 Tyr Ala Ser Gly Tyr Ala Asn Ile Gln Lys Thr Leu Tyr Val Gly 5045 5050 5055 tct gat ggt aca cta gag ggt acc caa tca caa gcc aag gtt gca 28735 Ser Asp Gly Thr Leu Glu Gly Thr Gln Ser Gln Ala Lys Val Ala 5060 5065 5070 tgg tat ttt tat aga acc aac act gat cca gtt aaa ctt tgt aag 28780 Trp Tyr Phe Tyr Arg Thr Asn Thr Asp Pro Val Lys Leu Cys Lys 5075 5080 5085 ggt gaa ttg ccg cgt aca cat aaa act cca ctt aca ttt agt tgc 28825 Gly Glu Leu Pro Arg Thr His Lys Thr Pro Leu Thr Phe Ser Cys 5090 5095 5100 agc aat aat aat ctt aca ctt ttt tca att aca aaa caa tat act 28870 Ser Asn Asn Asn Leu Thr Leu Phe Ser Ile Thr Lys Gln Tyr Thr 5105 5110 5115 ggt act tat tac agt aca aac ttt cat aca gga caa gat aaa tat 28915 Gly Thr Tyr Tyr Ser Thr Asn Phe His Thr Gly Gln Asp Lys Tyr 5120 5125 5130 tat act gtt aag gta gaa aat cct acc act cct aga act acc acc 28960 Tyr Thr Val Lys Val Glu Asn Pro Thr Thr Pro Arg Thr Thr Thr 5135 5140 5145 acc acc acc act act gca aag ccc act gtg aaa act aca act agg 29005 Thr Thr Thr Thr Thr Ala Lys Pro Thr Val Lys Thr Thr Thr Arg 5150 5155 5160 acc acc aca act aca gaa acc acc acc agc aca aca ctt gct gca 29050 Thr Thr Thr Thr Thr Glu Thr Thr Thr Ser Thr Thr Leu Ala Ala 5165 5170 5175 act aca cac aca cac act aag cta acc tta cag acc act aat gat 29095 Thr Thr His Thr His Thr Lys Leu Thr Leu Gln Thr Thr Asn Asp 5180 5185 5190 ttg atc gcc ctg ctg caa aag ggg gat aac agc acc act tcc aat 29140 Leu Ile Ala Leu Leu Gln Lys Gly Asp Asn Ser Thr Thr Ser Asn 5195 5200 5205 gag gag ata ccc aaa tcc atg att ggc att att gtt gct gta gtg 29185 Glu Glu Ile Pro Lys Ser Met Ile Gly Ile Ile Val Ala Val Val 5210 5215 5220 gtg tgc atg ttg atc atc gcc ttg tgc atg gtg tac tat gcc ttc 29230 Val Cys Met Leu Ile Ile Ala Leu Cys Met Val Tyr Tyr Ala Phe 5225 5230 5235 tgc tac aga aag cac aga ctg aac gac aag ctg gaa cac tta cta 29275 Cys Tyr Arg Lys His Arg Leu Asn Asp Lys Leu Glu His Leu Leu 5240 5245 5250 agt gtt gaa ttt taatttttta gaacc atg aag atc cta ggc ctt ttt 29323 Ser Val Glu Phe Met Lys Ile Leu Gly Leu Phe 5255 5260 agt ttt tct atc att acc tct gct ctt tgt gaa tca gtg gat aga 29368 Ser Phe Ser Ile Ile Thr Ser Ala Leu Cys Glu Ser Val Asp Arg 5265 5270 5275 gat gtt act att acc act ggt tct aat tat aca ctg aaa ggg cca 29413 Asp Val Thr Ile Thr Thr Gly Ser Asn Tyr Thr Leu Lys Gly Pro 5280 5285 5290 ccc tca ggt atg ctt tcg tgg tat tgc tat ttt gga act gac act 29458 Pro Ser Gly Met Leu Ser Trp Tyr Cys Tyr Phe Gly Thr Asp Thr 5295 5300 5305 gat caa act gaa tta tgc aat ttt caa aaa ggc aaa acc tca aac 29503 Asp Gln Thr Glu Leu Cys Asn Phe Gln Lys Gly Lys Thr Ser Asn 5310 5315 5320 tct aaa atc tct aat tat caa tgc aat ggc act gat ctg ata cta 29548 Ser Lys Ile Ser Asn Tyr Gln Cys Asn Gly Thr Asp Leu Ile Leu 5325 5330 5335 ctc aat gtc acg aaa gca tat ggt ggc agt tat tat tgc cct gga 29593 Leu Asn Val Thr Lys Ala Tyr Gly Gly Ser Tyr Tyr Cys Pro Gly 5340 5345 5350 caa aac act gaa gaa atg att ttt tac aaa gtg gaa gtg gtt gat 29638 Gln Asn Thr Glu Glu Met Ile Phe Tyr Lys Val Glu Val Val Asp 5355 5360 5365 ccc act aca cca ccc acc acc aca act att cat acc aca cac aca 29683 Pro Thr Thr Pro Pro Thr Thr Thr Thr Ile His Thr Thr His Thr 5370 5375 5380 gaa caa aca cca gag gca aca gaa gca gag ttg gcc ttc cag gtt 29728 Glu Gln Thr Pro Glu Ala Thr Glu Ala Glu Leu Ala Phe Gln Val 5385 5390 5395 cac gga gat tcc ttt gct gtc aat acc cct aca ccc gat cag cgg 29773 His Gly Asp Ser Phe Ala Val Asn Thr Pro Thr Pro Asp Gln Arg 5400 5405 5410 tgt ccg ggg ccg cta gtc agc ggc att gtc ggt gtg ctt tcg gga 29818 Cys Pro Gly Pro Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly 5415 5420 5425 tta gca gtc ata atc atc tgc atg ttc att ttt gct tgc tgc tat 29863 Leu Ala Val Ile Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr 5430 5435 5440 aga agg ctt tac cga caa aaa tca gac cca ctg ctg aac ctc tat 29908 Arg Arg Leu Tyr Arg Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr 5445 5450 5455 gtt taattttttc cagagcc atg aag gca gtt agc gct cta gtt ttt tgt 29958 Val Met Lys Ala Val Ser Ala Leu Val Phe Cys 5460 5465 tct ttg att gac att gtt ttt aat agt aaa att acc aaa gtt agc 30003 Ser Leu Ile Asp Ile Val Phe Asn Ser Lys Ile Thr Lys Val Ser 5470 5475 5480 ttt att aaa cat gtt aat gta act gaa gga gat aac atc aca cta 30048 Phe Ile Lys His Val Asn Val Thr Glu Gly Asp Asn Ile Thr Leu 5485 5490 5495 gca ggt gta gaa ggt gct caa aac acc acc tgg aca aaa tac cat 30093 Ala Gly Val Glu Gly Ala Gln Asn Thr Thr Trp Thr Lys Tyr His 5500 5505 5510 cta gga tgg aga gat att tgc acc tgg aat gta act tat tat tgc 30138 Leu Gly Trp Arg Asp Ile Cys Thr Trp Asn Val Thr Tyr Tyr Cys 5515 5520 5525 ata gga att aat ctt acc att gtt aac gct aac caa tct cag aat 30183 Ile Gly Ile Asn Leu Thr Ile Val Asn Ala Asn Gln Ser Gln Asn 5530 5535 5540 ggg tta att aaa gga cag agt gtt agt gtg acc agt gat ggg tac 30228 Gly Leu Ile Lys Gly Gln Ser Val Ser Val Thr Ser Asp Gly Tyr 5545 5550 5555 tat acc cag cat agt ttt aac tac aac att act gtc ata cca ctg 30273 Tyr Thr Gln His Ser Phe Asn Tyr Asn Ile Thr Val Ile Pro Leu 5560 5565 5570 cct acg cct agc cca cct agc act acc aca cag aca acc aca tac 30318 Pro Thr Pro Ser Pro Pro Ser Thr Thr Thr Gln Thr Thr Thr Tyr 5575 5580 5585 agt aca tca aat cag cct acc acc act aca gca gca gag gtt gcc 30363 Ser Thr Ser Asn Gln Pro Thr Thr Thr Thr Ala Ala Glu Val Ala 5590 5595 5600 agc tcg tct ggg gtc cga gtg gca ttt ttg atg ttg gcc cca tct 30408 Ser Ser Ser Gly Val Arg Val Ala Phe Leu Met Leu Ala Pro Ser 5605 5610 5615 agc agt ccc act gct agt acc aat gag cag act act gaa ttt ttg 30453 Ser Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Glu Phe Leu 5620 5625 5630 tcc act gtc gag agc cac acc aca gct acc tcc agt gcc ttc tct 30498 Ser Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe Ser 5635 5640 5645 agc acc gcc aat ctc tcc tcg ctt tcc tct aca cca atc agc ccc 30543 Ser Thr Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro 5650 5655 5660 gct act act cct agc ccc gct cct ctt ccc act ccc ctg aag caa 30588 Ala Thr Thr Pro Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys Gln 5665 5670 5675 aca gac ggc ggc atg caa tgg cag atc acc ctg ctc att gtg atc 30633 Thr Asp Gly Gly Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile 5680 5685 5690 ggg ttg gtc atc ctg gcc gtg ttg ctc tac tac atc ttc tgc cgc 30678 Gly Leu Val Ile Leu Ala Val Leu Leu Tyr Tyr Ile Phe Cys Arg 5695 5700 5705 cgc att ccc aac gcg cac cgc aag ccg gcc tac aag ccc atc gtt 30723 Arg Ile Pro Asn Ala His Arg Lys Pro Ala Tyr Lys Pro Ile Val 5710 5715 5720 atc ggg cag ccg gag ccg ctt cag gtg gaa ggg ggt cta agg aat 30768 Ile Gly Gln Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn 5725 5730 5735 ctt ctc ttc tct ttt aca gta tgg tgattgaact atgattccta 30812 Leu Leu Phe Ser Phe Thr Val Trp 5740 5745 gacaattctt gatcactatt cttatctgcc tcctccaagt ctgtgccacc ctcgctctgg 30872 tggccaacgc cagtccagac tgtattgggc ccttcgcctc ctacgtgctc tttgccttca 30932 tcacctgcat ctgctgctgt agcatagtct gcctgcttat caccttcttc cagttcattg 30992 actggatctt tgtgcgcatc gcctacctgc gccaccaccc ccagtaccgc gaccagcgag 31052 tggcgcagct gctcaggctc ctctgataag c atg cgg gct ctg cta ctt ctc 31104 Met Arg Ala Leu Leu Leu Leu 5750 gca ctt ctg ctg tta gtg ctc ccc cgt ccc gtt gac ccc cgg ccc 31149 Ala Leu Leu Leu Leu Val Leu Pro Arg Pro Val Asp Pro Arg Pro 5755 5760 5765 ccc act cag tcc ccc gag gag gtc cgc aaa tgc aaa ttc caa gaa 31194 Pro Thr Gln Ser Pro Glu Glu Val Arg Lys Cys Lys Phe Gln Glu 5770 5775 5780 ccc tgg aaa ttc ctc aaa tgc tac cgc caa aaa tca gac atg cat 31239 Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys Ser Asp Met His 5785 5790 5795 ccc agc tgg atc atg atc att ggg atc gtg aac att ctg gcc tgc 31284 Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile Leu Ala Cys 5800 5805 5810 acc ctc atc tcc ttt gtg att tac ccc tgc ttt gac ttt ggt tgg 31329 Thr Leu Ile Ser Phe Val Ile Tyr Pro Cys Phe Asp Phe Gly Trp 5815 5820 5825 aac tcg cca gag gcg ctc tat ctc ccg cct gaa cct gac aca cca 31374 Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr Pro 5830 5835 5840 cca cag caa cct cag gca cac gca cta cca cca cca cca cag cct 31419 Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Pro Pro Gln Pro 5845 5850 5855 agg cca caa tac atg ccc ata tta gac tat gag gcc gag cca cag 31464 Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln 5860 5865 5870 cga ccc atg ctc ccc gct att agt tac ttc aat cta acc ggc gga 31509 Arg Pro Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly 5875 5880 5885 gat gac tgacccactg gccaacaaca acgtcaacga ccttctcctg gacatggacg 31565 Asp Asp 5890 gccgcgcctc ggagcagcga ctcgcccaac ttcgcattcg ccagcagcag gagagagccg 31625 tcaaggagct gcaggacggc atagccatcc accagtgcaa gaaaggcatc ttctgcctgg 31685 tgaaacaggc caagatctcc tacgaggtca cccagaccga ccatcgcctc tcctacgagc 31745 tcctgcagca gcgccagaag ttcacctgcc tggtcggagt caaccccatc gtcatcaccc 31805 agcagtcggg cgataccaag gggtgcatcc actgctcctg cgactccccc gactgcgtcc 31865 acactctgat caagaccctc tgcggcctcc gcgacctcct ccccatgaac taatcacccc 31925 cttatccagt gaaataaaga tcatattgat gattaaataa aaaaaataat catttgattt 31985 gaaataaaga tacaatcata ttgatgattt gagtttaata aaaataaaga atcacttact 32045 tgaaatctga taccaggtct ctgtccatgt tttctgccaa caccacttca ctcccctctt 32105 cccagctctg gtactgcagg ccccggcggg ctgcaaactt cctccacacc ctgaagggga 32165 tgtcaaattc ctcctgtccc tcaatcttca ttttatcttc tatcag atg tcc aaa 32220 Met Ser Lys aag cgc gtc cgg gtg gat gat gac ttc gac ccc gtc tac ccc tac 32265 Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro Val Tyr Pro Tyr 5895 5900 5905 gat gca gac aac gca ccg acc gtg ccc ttc atc aac ccc ccc ttc 32310 Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro Phe 5910 5915 5920 gtc tct tca gat gga ttc caa gag aag ccc ctg ggg gtg ctg tcc 32355 Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser 5925 5930 5935 ctg cgt ctg gcc gat ccc gtc acc acc aag aac ggg gaa atc acc 32400 Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Glu Ile Thr 5940 5945 5950 ctc aag ctg gga gat ggg gtg gac ctc gac gac tcg gga aaa ctc 32445 Leu Lys Leu Gly Asp Gly Val Asp Leu Asp Asp Ser Gly Lys Leu 5955 5960 5965 atc tcc aac acg gcc acc aag gcc gcc gcc cct ctc agt ttt tcc 32490 Ile Ser Asn Thr Ala Thr Lys Ala Ala Ala Pro Leu Ser Phe Ser 5970 5975 5980 aac aac acc att tcc ctt aac atg gat acc cct ctt tac aac aac 32535 Asn Asn Thr Ile Ser Leu Asn Met Asp Thr Pro Leu Tyr Asn Asn 5985 5990 5995 aat gga aag cta ggt atg aag gta acc gca cca tta aag ata tta 32580 Asn Gly Lys Leu Gly Met Lys Val Thr Ala Pro Leu Lys Ile Leu 6000 6005 6010 gac aca gat cta cta aaa aca ctt gtt gtt gct tat ggg cag gga 32625 Asp Thr Asp Leu Leu Lys Thr Leu Val Val Ala Tyr Gly Gln Gly 6015 6020 6025 tta gga aca aac acc aat ggt gct ctt gtt gcc caa cta gca tac 32670 Leu Gly Thr Asn Thr Asn Gly Ala Leu Val Ala Gln Leu Ala Tyr 6030 6035 6040 cca ctt gtt ttt aat acc gct agc aaa att gcc ctt aat tta ggc 32715 Pro Leu Val Phe Asn Thr Ala Ser Lys Ile Ala Leu Asn Leu Gly 6045 6050 6055 aat gga cca tta aaa gtg gat gca aat aga ctg aac att aat tgc 32760 Asn Gly Pro Leu Lys Val Asp Ala Asn Arg Leu Asn Ile Asn Cys 6060 6065 6070 aaa aga ggt atc tat gtc act acc aca aaa gat gca ctg gag att 32805 Lys Arg Gly Ile Tyr Val Thr Thr Thr Lys Asp Ala Leu Glu Ile 6075 6080 6085 aat atc agt tgg gca aat gct atg aca ttt ata gga aat gcc att 32850 Asn Ile Ser Trp Ala Asn Ala Met Thr Phe Ile Gly Asn Ala Ile 6090 6095 6100 ggt gtc aat att gac aca aaa aaa ggc cta cag ttc ggc act tca 32895 Gly Val Asn Ile Asp Thr Lys Lys Gly Leu Gln Phe Gly Thr Ser 6105 6110 6115 agc act gaa aca gat gtt aaa aat gct ttt cca ctc caa gta aaa 32940 Ser Thr Glu Thr Asp Val Lys Asn Ala Phe Pro Leu Gln Val Lys 6120 6125 6130 ctt gga gct ggt ctt aca ttt gac agc aca ggt gcc att gtt gct 32985 Leu Gly Ala Gly Leu Thr Phe Asp Ser Thr Gly Ala Ile Val Ala 6135 6140 6145 tgg aac aaa gaa gat gac aaa ctt aca ctg tgg acc aca gcc gat 33030 Trp Asn Lys Glu Asp Asp Lys Leu Thr Leu Trp Thr Thr Ala Asp 6150 6155 6160 cca tct cca aac tgt cac ata tat tct gca aag gat gct aag ctt 33075 Pro Ser Pro Asn Cys His Ile Tyr Ser Ala Lys Asp Ala Lys Leu 6165 6170 6175 aca ctc tgc ttg aca aag tgt ggt agt cag ata ctg ggc act gtt 33120 Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly Thr Val 6180 6185 6190 tct ctc ata gct gtt gat act ggt agc tta aat cca ata aca gga 33165 Ser Leu Ile Ala Val Asp Thr Gly Ser Leu Asn Pro Ile Thr Gly 6195 6200 6205 caa gta acc act gct ctt gtt tca ctt aaa ttc gat gcc aat gga 33210 Gln Val Thr Thr Ala Leu Val Ser Leu Lys Phe Asp Ala Asn Gly 6210 6215 6220 gtt ttg caa acc agt tca aca ttg gac aaa gaa tat tgg aat ttt 33255 Val Leu Gln Thr Ser Ser Thr Leu Asp Lys Glu Tyr Trp Asn Phe 6225 6230 6235 aga aaa gga gat gtg aca cct gct gag cca tat act aat gct ata 33300 Arg Lys Gly Asp Val Thr Pro Ala Glu Pro Tyr Thr Asn Ala Ile 6240 6245 6250 ggt ttt atg ccc aat ata aag gca tat ccg aaa aac aca aat tca 33345 Gly Phe Met Pro Asn Ile Lys Ala Tyr Pro Lys Asn Thr Asn Ser 6255 6260 6265 gct gca aaa agt cac att gtg gga aaa gta tac cta cat ggg gaa 33390 Ala Ala Lys Ser His Ile Val Gly Lys Val Tyr Leu His Gly Glu 6270 6275 6280 gta agc aag cca cta gac ttg ata att aca ttt aat gaa acc agt 33435 Val Ser Lys Pro Leu Asp Leu Ile Ile Thr Phe Asn Glu Thr Ser 6285 6290 6295 aat gaa acc tgt acc tat tgc att aac ttt cag tgg cag tgg gga 33480 Asn Glu Thr Cys Thr Tyr Cys Ile Asn Phe Gln Trp Gln Trp Gly 6300 6305 6310 act gac aaa tat aaa aat gaa acg ctt gct gtc agt tca ttc acc 33525 Thr Asp Lys Tyr Lys Asn Glu Thr Leu Ala Val Ser Ser Phe Thr 6315 6320 6325 ttt tcc tac att gcc caa gaa taaacccgcc ctgcatgtca accccattgt 33576 Phe Ser Tyr Ile Ala Gln Glu 6330 6335 tcccaccact atggaaaact ctgaagcaga aaaataaagt tcaagtgttt tattgattca 33636 acagttttca cagaattcga gtagttattt ttcctccacc ctcccaggac atggaataca 33696 ccaccctctc cccccgcaca gccttgaaca tctgaatgtc attggtgatg gacatgcttt 33756 tggtctccac attccacaca gtttcagagc gagccagtct cgggtcggtc agggagatga 33816 aaccctccgg gcactcccgc atctgcacct caaagttcag tagctgaggg ctgtcctcgg 33876 tggtcgggat cacggttatc tggaagaagc agaagagcgg cggtgggaat catagtccgc 33936 gaacgggatc ggccggtggt gtcgcatcag gccccgcagc agtcgctgtc gccgccgctc 33996 cgtcaaactg ctgctcaggg ggtccgggtc cagggactcc ctcagcatga tgcccacggc 34056 cctcagcatc agtcgcctgg tgcggcgggc gcagcagcgc atgcggatct cgctcaggtc 34116 gctgcagtac gtgcaacaca ggaccaccag gttgttcaac agtccatagt tcaacacgct 34176 ccagccgaaa ctcatcgcgg gaaggatgct acccacgtgg ccgtcgtacc agatcctcag 34236 gtaaatcaag tggcgctccc tccagaacac gctgcccaca tacatgatct ccttgggcat 34296 gtggtggttc accacctccc ggtaccacat caccctctgg ttgaacatgc agccccggat 34356 gatcctgcgg aaccacaggg ccagcaccgc cccgcccgcc atgcagcgaa gagaccccgg 34416 gtcccggcaa tggcaatgga ggacccaccg ctcgtacccg tggatcatct gggagctgaa 34476 caagtctatg ttggcacagc acaggcacac gctcatgcat ctcttcagca ctctcagctc 34536 ctcgggggtc aaaaccatat cccagggcac ggggaactct tgcaggacag cgaaccccgc 34596 agaacagggc aatcctcgca cataacttac attgtgcatg gacagggtat cgcaatcagg 34656 cagcaccggg tgatcctcca ccagagaagc gcgggtctcg gtttcctcac agcgtggtaa 34716 gggggccggc cgatacgggt gatggcggga cgcggctgat cgtgttctcg accgtgtcat 34776 gatgcagttg ctttcggaca ttttcgtact tgctgtagca gaacctggtc cgggcgctgc 34836 acaccgatcg ccggcggcgg tctcggcgct tggaacgctc ggtgttgaaa ttgtaaaaca 34896 gccactctct cagaccgtgc agcagatcta gggcctcagg agtgatgaag atcccatcat 34956 gcctgatggc tctgatcaca tcgaccaccg tggaatgggc cagacccagc cagatgatgc 35016 aattttgttg ggtttcggtg acggcggggg agggaagaac aggaagaacc atgattaact 35076 tttaatccaa acggtctcgg agcacttcaa aatgaaggtc gcggagatgg cacctctcgc 35136 ccccgctgtg ttggtggaaa ataacagcca ggtcaaaggt gatacggttc tcgagatgtt 35196 ccacggtggc ttccagcaaa gcctccacgc gcacatccag aaacaagaca atagcgaaag 35256 cgggagggtt ctctaattcc tcaatcatca tgttacactc ctgcaccatc cccagataat 35316 tttcattttt ccagccttga atgattcgaa ctagttcctg aggtaaatcc aagccagcca 35376 tgataaagag ctcgcgcaga gcgccctcca ccggcattct taagcacacc ctcataattc 35436 caagagattc tgctcctggt tcacctgcag cagattaaca aggggaatat caaaatctct 35496 gccgcgatct ctaagctcct ccctcagcaa taactgcaag tactctttca tatcttctcc 35556 gaaattttta gccatagggc cgccaggaat gagagcaggg caagccacat tacagataaa 35616 gcgaagtcct ccccagtgag cattgccaaa tgtaagattg aaataagcat gctggctaga 35676 cccggtgata tcttccagat aactggacag aaaatcaggc aagcaatttt taagaaaatc 35736 aacaaaagaa aagtcgtcca ggtgcaagtt tagagcctca ggaacaacga tggaataagt 35796 gcaaggagtg cgttccagca tggttagtgt ttttttggtg atctgtagaa caaaaaataa 35856 acatgcaata ttaaaccatg ctagcctggc gaacaggtgg gtaaatcact ctttccagca 35916 ccaggcaggc tacggggtct ccggcgcgac cctcgtagaa gctgtcgcca tgattgaaaa 35976 gcatcaccga aagactttcc cggtggccgg catggatgat tcgcgaagac gcgtacactc 36036 cgggaacatt ggcatccgtg agtgaaaaaa atcgccccaa gaagccccga ggcactacaa 36096 tgctcaacct taattccagc agagcgaccc catgcggatg aagcacaaaa ttggtaggtg 36156 cgtaaaaaat gtaattactc ccctcctgca caggcagcaa agcccccgct ccctccagaa 36216 acacatacaa agcctcagcg tccatagctt accgagcacg gcaggcgcaa gattcagaga 36276 aaaggctgag ctctaacctg actgcccgct cctgagctca atatatagcc ctaacctaca 36336 ctgacgtaaa ggccaaagtc taaaaatacc cgccaaaatg acacacacgc ccagcacacg 36396 cccagaaacc ggtgacacac tcaaaaaaat acgtgcgctt cctcaaacgc ccaaaccggc 36456 gtcatttccg ggttcccacg ctacgtcacc gctcagcgac tttcaaattt cgtcgaccgt 36516 taaacacgtc actcgccccg cccctaacgg tcgccgctcc cacagccaat caccttcctc 36576 catccccaaa ttcaaacggc tcatttgcat attaacgcgc accaaaagtt tgaggtatat 36636 tatwkakrww g 36647 <210> 51 <211> 191 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 51 Met Glu Ile Trp Thr Val Leu Glu Asp Phe His Gln Thr Arg Gln Leu 1 5 10 15 Leu Glu Asn Ser Ser Glu Gly Val Ser Tyr Leu Trp Arg Phe Cys Phe 20 25 30 Ala Gly Pro Leu Ala Lys Leu Val Tyr Arg Ala Lys Gln Asp Tyr Arg 35 40 45 Glu Gln Phe Glu Asp Ile Leu Arg Glu Cys Pro Gly Ile Phe Asp Ser 50 55 60 Leu Asn Leu Gly His Gln Ser His Phe Asn Gln Ser Ile Leu Arg Ala 65 70 75 80 Leu Asp Phe Ser Thr Pro Gly Arg Thr Thr Ala Ala Val Ala Phe Phe 85 90 95 Ala Phe Ile Leu Asp Lys Trp Ser Gln Glu Thr His Phe Ser Arg Asp 100 105 110 Tyr Arg Leu Asp Cys Leu Ala Val Ala Leu Trp Arg Thr Trp Arg Cys 115 120 125 Gln Arg Leu Asn Ala Ile Ser Gly Tyr Leu Pro Val Gln Pro Val Asp 130 135 140 Thr Leu Arg Ile Leu Ser Leu Gln Ser Pro Gln Glu His Gln Arg Arg 145 150 155 160 Gln Gln Pro Gln Gln Glu Gln Gln Gln Glu Glu Glu Asp Arg Glu Glu 165 170 175 Asn Pro Arg Ala Gly Leu Asp Pro Pro Val Ala Glu Glu Glu Glu 180 185 190 <210> 52 <211> 392 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 52 Met His Pro Val Leu Arg Gln Met Arg Pro His Pro Pro Pro Gln Pro 1 5 10 15 Pro Leu Pro Gln Gln Gln Gln Gln Pro Ala Leu Leu Pro Pro Pro Gln 20 25 30 Gln Gln Gln Gln Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala 35 40 45 Gly Val Gln Tyr Asp Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala Arg 50 55 60 Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys Arg 65 70 75 80 Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp Arg 85 90 95 Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ser Arg Phe His Ala Gly 100 105 110 Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp Glu 115 120 125 Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala His 130 135 140 Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys Glu 145 150 155 160 Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu Ile 165 170 175 Ala Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu Leu 180 185 190 Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln Leu 195 200 205 Phe Leu Val Val Gln His Ser Arg Asp Asn Glu Thr Phe Arg Glu Ala 210 215 220 Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu Val 225 230 235 240 Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu Ser 245 250 255 Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys Tyr 260 265 270 Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys Glu 275 280 285 Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu Thr 290 295 300 Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg Ala 305 310 315 320 Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met His 325 330 335 Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser Tyr 340 345 350 Phe Asp Met Gly Ala Asp Leu Arg Trp Gln Pro Ser Arg Arg Ala Leu 355 360 365 Glu Ala Ala Gly Gly Val Pro Tyr Val Glu Glu Val Asp Asp Glu Glu 370 375 380 Glu Glu Gly Glu Tyr Leu Glu Asp 385 390 <210> 53 <211> 586 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 53 Met Gln Gln Gln Pro Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu 1 5 10 15 Gln Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala 20 25 30 Met Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg 35 40 45 Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val 50 55 60 Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn 65 70 75 80 Ala Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val 85 90 95 Tyr Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val 100 105 110 Gln Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ser 115 120 125 Gln Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala 130 135 140 Leu Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln 145 150 155 160 Glu Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Ala Glu 165 170 175 Val Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln 180 185 190 Thr Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys 195 200 205 Asn Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala 210 215 220 Thr Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu 225 230 235 240 Val Ala Pro Phe Thr Asp Ser Gly Ser Val Ser Arg Asp Ser Tyr Leu 245 250 255 Gly Tyr Leu Leu Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val 260 265 270 Asp Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly 275 280 285 Gln Glu Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr 290 295 300 Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu 305 310 315 320 Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met 325 330 335 Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn 340 345 350 Met Glu Pro Ser Met Tyr Ala Arg Asn Arg Pro Phe Ile Asn Lys Leu 355 360 365 Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr 370 375 380 Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr 385 390 395 400 Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp 405 410 415 Val Asp Ser Ser Val Phe Ser Pro Arg Pro Thr Thr Thr Val Trp Lys 420 425 430 Lys Glu Gly Gly Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly Arg Ala 435 440 445 Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu 450 455 460 Pro Phe Ser Leu Asn Ser Val Arg Ser Ser Asp Leu Gly Arg Leu Thr 465 470 475 480 Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu 485 490 495 Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu 500 505 510 Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala His Glu His Arg Asp 515 520 525 Glu Pro Arg Ala Ser Ser Ser Thr Gly Ala Arg Arg Arg Gln Arg His 530 535 540 Asp Arg Gln Arg Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp Asp 545 550 555 560 Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe Ala 565 570 575 His Leu Arg Pro Arg Ile Gly Arg Leu Met 580 585 <210> 54 <211> 539 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 54 Met Met Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Val Ala Ala Ala Met Gln Pro Pro Leu Glu Ala 20 25 30 Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg Asn Ser 35 40 45 Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg Leu Tyr 50 55 60 Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr Gln Asn 65 70 75 80 Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp Phe Thr 85 90 95 Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg 100 105 110 Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro Asn Val 115 120 125 Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser 130 135 140 Arg Lys Thr Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln Asp Glu 145 150 155 160 Leu Thr Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn Phe Ser 165 170 175 Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr 180 185 190 Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val 195 200 205 Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val Thr Glu 210 215 220 Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro Asp Ile 225 230 235 240 Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg Leu Ser 245 250 255 Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly Phe Gln 260 265 270 Ile Leu Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp 275 280 285 Val Glu Ala Tyr Glu Lys Ser Lys Glu Glu Ala Ala Ala Ala Ala Thr 290 295 300 Ala Ala Val Ala Thr Ala Ala Thr Thr Asp Ala Asp Ala Ala Thr Thr 305 310 315 320 Thr Arg Gly Asp Thr Phe Ala Thr Gln Ala Glu Glu Ala Ala Ala Leu 325 330 335 Ala Ala Thr Asp Asp Ser Glu Ser Lys Ile Val Ile Lys Pro Val Glu 340 345 350 Lys Asp Ser Lys Asp Arg Ser Tyr Asn Val Leu Ser Asp Gly Lys Asn 355 360 365 Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly Asp Pro Glu 370 375 380 Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp Val Thr Cys 385 390 395 400 Gly Val Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met Gln Asp Pro 405 410 415 Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn Tyr Pro Val Val Gly 420 425 430 Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser Phe Phe Asn Glu Gln Ala 435 440 445 Val Tyr Ser Gln Gln Leu Arg Ala Phe Thr Ser Leu Thr His Val Phe 450 455 460 Asn Arg Phe Pro Glu Asn Gln Ile Leu Val Arg Pro Pro Ala Pro Thr 465 470 475 480 Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr 485 490 495 Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val Thr Val Thr 500 505 510 Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Val 515 520 525 Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 530 535 <210> 55 <211> 194 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 55 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Ala Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ser 130 135 140 Ser Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala 145 150 155 160 Ala Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val 165 170 175 Arg Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro 180 185 190 Arg Thr <210> 56 <211> 346 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 56 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys Glu Glu Arg Lys Pro Arg 20 25 30 Lys Leu Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Glu Asp Asp Gly 35 40 45 Leu Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp 50 55 60 Arg Gly Arg Lys Val Lys Pro Val Leu Arg Pro Gly Thr Thr Val Val 65 70 75 80 Phe Thr Pro Gly Glu Arg Ser Gly Ser Ala Ser Lys Arg Ser Tyr Asp 85 90 95 Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu 100 105 110 Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Pro Ala Pro Leu Lys Glu 115 120 125 Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu 130 135 140 Lys Pro Val Thr Leu Gln Gln Val Leu Pro Ser Ala Ala Pro Arg Arg 145 150 155 160 Gly Phe Lys Arg Glu Gly Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu 165 170 175 Met Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu His Met Lys 180 185 190 Val Asp Pro Glu Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln 195 200 205 Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr 210 215 220 Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr 225 230 235 240 Met Glu Val Gln Thr Asp Pro Trp Met Pro Ala Pro Ala Ser Thr Thr 245 250 255 Thr Arg Arg Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn 260 265 270 Tyr Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr 275 280 285 Arg Phe Tyr Arg Gly Tyr Ser Ser Arg Arg Lys Thr Thr Thr Arg Arg 290 295 300 Arg Arg Arg Arg Thr Arg Arg Ser Thr Thr Ala Thr Ser Ala Ala Ala 305 310 315 320 Leu Val Arg Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu Thr Leu Pro 325 330 335 Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 340 345 <210> 57 <211> 77 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 57 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly Asn Gly Leu Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 58 <211> 239 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 58 Met Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg 1 5 10 15 Pro Phe Met Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly 20 25 30 Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly 35 40 45 Ser Thr Leu Lys Thr Tyr Gly Asn Lys Ala Trp Asn Ser Ser Thr Gly 50 55 60 Gln Ala Leu Arg Glu Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val 65 70 75 80 Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn 85 90 95 Gln Ala Val Gln Lys Gln Ile Asn Ser Arg Leu Asp Ala Val Pro Pro 100 105 110 Ala Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu 115 120 125 Asp Lys Arg Gly Asp Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu 130 135 140 Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu 145 150 155 160 Gly Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu 165 170 175 Lys Pro Glu Ser Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Pro Thr 180 185 190 Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Arg Ala 195 200 205 Arg Pro Gly Ser Arg Pro Gln Ala Asn Trp Gln Ser Thr Leu Asn Ser 210 215 220 Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg Arg Arg Cys Tyr 225 230 235 <210> 59 <211> 944 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 59 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Ser Ser Gln Trp Glu Gln Thr Glu Asn Gly Gly Gly Gln 130 135 140 Ala Thr Thr Lys Thr His Thr Tyr Gly Val Ala Pro Met Gly Gly Thr 145 150 155 160 Asn Ile Thr Val Asp Gly Leu Gln Ile Gly Thr Asp Ala Thr Ala Asp 165 170 175 Thr Glu Lys Pro Ile Tyr Ala Asp Lys Thr Phe Gln Pro Glu Pro Gln 180 185 190 Ile Gly Glu Glu Asn Trp Gln Glu Thr Glu Ser Phe Tyr Gly Gly Arg 195 200 205 Ala Leu Lys Lys Asp Thr Asn Met Lys Pro Cys Tyr Gly Ser Phe Ala 210 215 220 Arg Pro Thr Asn Glu Lys Gly Gly Gln Ala Lys Leu Lys Val Gly Ala 225 230 235 240 Asp Gly Leu Pro Thr Lys Glu Phe Asp Ile Asp Leu Ala Phe Phe Asp 245 250 255 Thr Pro Gly Gly Thr Val Thr Gly Gly Thr Glu Glu Tyr Lys Ala Asp 260 265 270 Ile Val Met Tyr Thr Glu Asn Thr Tyr Leu Glu Thr Pro Asp Thr His 275 280 285 Val Val Tyr Lys Pro Gly Lys Asp Asn Thr Ser Ser Lys Ile Asn Leu 290 295 300 Val Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp 305 310 315 320 Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val 325 330 335 Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp 340 345 350 Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp 355 360 365 Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp 370 375 380 Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro 385 390 395 400 Asn Tyr Cys Phe Pro Leu Asp Gly Ser Gly Thr Asn Ala Ala Tyr Gln 405 410 415 Gly Val Lys Val Lys Asn Gly Gln Asp Gly Asp Val Glu Ser Glu Trp 420 425 430 Glu Lys Asp Asp Thr Val Ala Ala Arg Asn Gln Leu Cys Lys Gly Asn 435 440 445 Ile Phe Ala Met Glu Ile Asn Leu Gln Ala Asn Leu Trp Arg Ser Phe 450 455 460 Leu Tyr Ser Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr 465 470 475 480 Pro Ala Asn Ile Thr Leu Pro Thr Asn Thr Asn Thr Tyr Asp Tyr Met 485 490 495 Asn Gly Arg Val Val Pro Pro Ser Leu Val Asp Ala Tyr Ile Asn Ile 500 505 510 Gly Ala Arg Trp Ser Leu Asp Pro Met Asp Asn Val Asn Pro Phe Asn 515 520 525 His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn 530 535 540 Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala 545 550 555 560 Ile Lys Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn 565 570 575 Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp 580 585 590 Leu Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr 595 600 605 Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala 610 615 620 Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser 625 630 635 640 Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Val Pro 645 650 655 Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe 660 665 670 Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp 675 680 685 Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe 690 695 700 Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe Asp Ser Ser 705 710 715 720 Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu 725 730 735 Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn 740 745 750 Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile 755 760 765 Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr 770 775 780 Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu 785 790 795 800 Val Asn Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn 805 810 815 Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln 820 825 830 Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val 835 840 845 Thr Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met Trp Arg 850 855 860 Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu 865 870 875 880 Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Asn 885 890 895 Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr Val Val Phe 900 905 910 Glu Val Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile 915 920 925 Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 930 935 940 <210> 60 <211> 208 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 60 Met Ala Glu Pro Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile 1 5 10 15 Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg 20 25 30 Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn 35 40 45 Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp 50 55 60 Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser 65 70 75 80 Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu Leu 85 90 95 Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu Lys 100 105 110 Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu Phe 115 120 125 Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro Met 130 135 140 Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly Met 145 150 155 160 Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu Ala 165 170 175 Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe Arg Ser His Arg 180 185 190 Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Gln Asp Met 195 200 205 <210> 61 <211> 803 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 61 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ser 1 5 10 15 Thr Ala Asp Glu Asn Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro 20 25 30 Pro Ser Pro Thr Ser Asp Ala Ala Ala Pro Asp Met Gln Glu Met Glu 35 40 45 Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu 50 55 60 Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln Glu 65 70 75 80 Gln Pro Glu Gln Glu Ala Glu Asn Glu Gln Asn Gln Ala Gly His Glu 85 90 95 His Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu Ile Lys His Leu 100 105 110 Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Ala Glu 115 120 125 Val Pro Leu Ser Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg Asn Leu 130 135 140 Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys Glu 145 150 155 160 Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu Ala 165 170 175 Leu Ala Thr Tyr His Leu Phe Phe Lys Asn Gln Arg Ile Pro Val Ser 180 185 190 Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Phe Asn Leu Gly Pro 195 200 205 Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro Lys Ile 210 215 220 Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu Gln 225 230 235 240 Gly Glu Gly Gly Glu His Glu His His Ser Ala Leu Val Glu Leu Glu 245 250 255 Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu Thr 260 265 270 His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser Ala 275 280 285 Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Ile Ser Glu Asp 290 295 300 Glu Gly Met Gln Asp Pro Glu Ser Thr Glu Asp Gly Lys Pro Val Val 305 310 315 320 Ser Asp Glu Gln Leu Ala Arg Trp Leu Gly Pro Asn Ala Ser Pro Gln 325 330 335 Ser Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr 340 345 350 Val Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu 355 360 365 Arg Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val 370 375 380 Arg Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser 385 390 395 400 Tyr Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His 405 410 415 Thr Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val 420 425 430 Tyr Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln 435 440 445 Gln Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln 450 455 460 Lys Asn Leu Lys Gly Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala 465 470 475 480 Ser Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu 485 490 495 Arg Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe 500 505 510 Arg Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser 515 520 525 Ala Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro 530 535 540 Pro Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala 545 550 555 560 Tyr His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu 565 570 575 Cys His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys 580 585 590 Asn Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu 595 600 605 Gln Gly Pro Ser Asp Glu Gly Ser Ala Ala Lys Gly Gly Leu Lys Leu 610 615 620 Thr Pro Gly Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu 625 630 635 640 Asp Tyr His Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro 645 650 655 Pro Lys Ala Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu 660 665 670 Ala Gln Leu Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys 675 680 685 Lys Gly Arg Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn 690 695 700 Pro Gly Phe Pro Gln Asp Ala Pro Arg Lys Gln Glu Ala Glu Ser Gly 705 710 715 720 Ala Ala Ala Arg Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Gln Ser 725 730 735 Gly Arg Gly Gly Gly Asp Gly Gly Arg Leu Gly Gln His Ser Gly Arg 740 745 750 Gly Gly Gln Pro Ala Arg Gln Ser Gly Gly Arg Arg Gly Gly Gly Arg 755 760 765 Gly Gly Arg Ser Ser Arg Arg Gln Thr Val Val Leu Gly Gly Gly Glu 770 775 780 Ser Lys Gln His Gly Tyr His Leu Arg Ser Gly Ser Gly Ser Arg Ser 785 790 795 800 Ala Pro Gln <210> 62 <211> 227 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 62 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala Arg Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Ala Ala Thr 50 55 60 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 63 <211> 106 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 63 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Ala 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Ile Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Arg Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asn His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 64 <211> 176 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 64 Met Gly Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val Leu 1 5 10 15 Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu Glu Lys Ala 20 25 30 Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Val Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Ala His Met Cys Asn Thr Val Met Trp Met Ser Lys Gln Tyr Asp Met 115 120 125 Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Leu Cys Thr Ala Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 65 <211> 228 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 65 Met Arg Leu Leu Asn Phe Leu Asn Ile Val Leu Ser Ile Ala Tyr Ala 1 5 10 15 Ser Gly Tyr Ala Asn Ile Gln Lys Thr Leu Tyr Val Gly Ser Asp Gly 20 25 30 Thr Leu Glu Gly Thr Gln Ser Gln Ala Lys Val Ala Trp Tyr Phe Tyr 35 40 45 Arg Thr Asn Thr Asp Pro Val Lys Leu Cys Lys Gly Glu Leu Pro Arg 50 55 60 Thr His Lys Thr Pro Leu Thr Phe Ser Cys Ser Asn Asn Asn Leu Thr 65 70 75 80 Leu Phe Ser Ile Thr Lys Gln Tyr Thr Gly Thr Tyr Tyr Ser Thr Asn 85 90 95 Phe His Thr Gly Gln Asp Lys Tyr Tyr Thr Val Lys Val Glu Asn Pro 100 105 110 Thr Thr Pro Arg Thr Thr Thr Thr Thr Thr Thr Thr Ala Lys Pro Thr 115 120 125 Val Lys Thr Thr Thr Arg Thr Thr Thr Thr Thr Glu Thr Thr Thr Ser 130 135 140 Thr Thr Leu Ala Ala Thr Thr His Thr His Thr Lys Leu Thr Leu Gln 145 150 155 160 Thr Thr Asn Asp Leu Ile Ala Leu Leu Gln Lys Gly Asp Asn Ser Thr 165 170 175 Thr Ser Asn Glu Glu Ile Pro Lys Ser Met Ile Gly Ile Ile Val Ala 180 185 190 Val Val Val Cys Met Leu Ile Ile Ala Leu Cys Met Val Tyr Tyr Ala 195 200 205 Phe Cys Tyr Arg Lys His Arg Leu Asn Asp Lys Leu Glu His Leu Leu 210 215 220 Ser Val Glu Phe 225 <210> 66 <211> 203 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 66 Met Lys Ile Leu Gly Leu Phe Ser Phe Ser Ile Ile Thr Ser Ala Leu 1 5 10 15 Cys Glu Ser Val Asp Arg Asp Val Thr Ile Thr Thr Gly Ser Asn Tyr 20 25 30 Thr Leu Lys Gly Pro Pro Ser Gly Met Leu Ser Trp Tyr Cys Tyr Phe 35 40 45 Gly Thr Asp Thr Asp Gln Thr Glu Leu Cys Asn Phe Gln Lys Gly Lys 50 55 60 Thr Ser Asn Ser Lys Ile Ser Asn Tyr Gln Cys Asn Gly Thr Asp Leu 65 70 75 80 Ile Leu Leu Asn Val Thr Lys Ala Tyr Gly Gly Ser Tyr Tyr Cys Pro 85 90 95 Gly Gln Asn Thr Glu Glu Met Ile Phe Tyr Lys Val Glu Val Val Asp 100 105 110 Pro Thr Thr Pro Pro Thr Thr Thr Thr Ile His Thr Thr His Thr Glu 115 120 125 Gln Thr Pro Glu Ala Thr Glu Ala Glu Leu Ala Phe Gln Val His Gly 130 135 140 Asp Ser Phe Ala Val Asn Thr Pro Thr Pro Asp Gln Arg Cys Pro Gly 145 150 155 160 Pro Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly Leu Ala Val Ile 165 170 175 Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr Arg 180 185 190 Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 195 200 <210> 67 <211> 288 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 67 Met Lys Ala Val Ser Ala Leu Val Phe Cys Ser Leu Ile Asp Ile Val 1 5 10 15 Phe Asn Ser Lys Ile Thr Lys Val Ser Phe Ile Lys His Val Asn Val 20 25 30 Thr Glu Gly Asp Asn Ile Thr Leu Ala Gly Val Glu Gly Ala Gln Asn 35 40 45 Thr Thr Trp Thr Lys Tyr His Leu Gly Trp Arg Asp Ile Cys Thr Trp 50 55 60 Asn Val Thr Tyr Tyr Cys Ile Gly Ile Asn Leu Thr Ile Val Asn Ala 65 70 75 80 Asn Gln Ser Gln Asn Gly Leu Ile Lys Gly Gln Ser Val Ser Val Thr 85 90 95 Ser Asp Gly Tyr Tyr Thr Gln His Ser Phe Asn Tyr Asn Ile Thr Val 100 105 110 Ile Pro Leu Pro Thr Pro Ser Pro Pro Ser Thr Thr Thr Gln Thr Thr 115 120 125 Thr Tyr Ser Thr Ser Asn Gln Pro Thr Thr Thr Thr Ala Ala Glu Val 130 135 140 Ala Ser Ser Ser Gly Val Arg Val Ala Phe Leu Met Leu Ala Pro Ser 145 150 155 160 Ser Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Glu Phe Leu Ser 165 170 175 Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe Ser Ser Thr 180 185 190 Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro Ala Thr Thr 195 200 205 Pro Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys Gln Thr Asp Gly Gly 210 215 220 Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly Leu Val Ile Leu 225 230 235 240 Ala Val Leu Leu Tyr Tyr Ile Phe Cys Arg Arg Ile Pro Asn Ala His 245 250 255 Arg Lys Pro Ala Tyr Lys Pro Ile Val Ile Gly Gln Pro Glu Pro Leu 260 265 270 Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser Phe Thr Val Trp 275 280 285 <210> 68 <211> 144 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 68 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu Val Leu Pro Arg 1 5 10 15 Pro Val Asp Pro Arg Pro Pro Thr Gln Ser Pro Glu Glu Val Arg Lys 20 25 30 Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys 35 40 45 Ser Asp Met His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile 50 55 60 Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Cys Phe Asp Phe 65 70 75 80 Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr 85 90 95 Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Pro Pro Gln Pro 100 105 110 Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg 115 120 125 Pro Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 130 135 140 <210> 69 <211> 445 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 69 Met Ser Lys Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro Val Tyr 1 5 10 15 Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro 20 25 30 Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser 35 40 45 Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu 50 55 60 Lys Leu Gly Asp Gly Val Asp Leu Asp Asp Ser Gly Lys Leu Ile Ser 65 70 75 80 Asn Thr Ala Thr Lys Ala Ala Ala Pro Leu Ser Phe Ser Asn Asn Thr 85 90 95 Ile Ser Leu Asn Met Asp Thr Pro Leu Tyr Asn Asn Asn Gly Lys Leu 100 105 110 Gly Met Lys Val Thr Ala Pro Leu Lys Ile Leu Asp Thr Asp Leu Leu 115 120 125 Lys Thr Leu Val Val Ala Tyr Gly Gln Gly Leu Gly Thr Asn Thr Asn 130 135 140 Gly Ala Leu Val Ala Gln Leu Ala Tyr Pro Leu Val Phe Asn Thr Ala 145 150 155 160 Ser Lys Ile Ala Leu Asn Leu Gly Asn Gly Pro Leu Lys Val Asp Ala 165 170 175 Asn Arg Leu Asn Ile Asn Cys Lys Arg Gly Ile Tyr Val Thr Thr Thr 180 185 190 Lys Asp Ala Leu Glu Ile Asn Ile Ser Trp Ala Asn Ala Met Thr Phe 195 200 205 Ile Gly Asn Ala Ile Gly Val Asn Ile Asp Thr Lys Lys Gly Leu Gln 210 215 220 Phe Gly Thr Ser Ser Thr Glu Thr Asp Val Lys Asn Ala Phe Pro Leu 225 230 235 240 Gln Val Lys Leu Gly Ala Gly Leu Thr Phe Asp Ser Thr Gly Ala Ile 245 250 255 Val Ala Trp Asn Lys Glu Asp Asp Lys Leu Thr Leu Trp Thr Thr Ala 260 265 270 Asp Pro Ser Pro Asn Cys His Ile Tyr Ser Ala Lys Asp Ala Lys Leu 275 280 285 Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Ser 290 295 300 Leu Ile Ala Val Asp Thr Gly Ser Leu Asn Pro Ile Thr Gly Gln Val 305 310 315 320 Thr Thr Ala Leu Val Ser Leu Lys Phe Asp Ala Asn Gly Val Leu Gln 325 330 335 Thr Ser Ser Thr Leu Asp Lys Glu Tyr Trp Asn Phe Arg Lys Gly Asp 340 345 350 Val Thr Pro Ala Glu Pro Tyr Thr Asn Ala Ile Gly Phe Met Pro Asn 355 360 365 Ile Lys Ala Tyr Pro Lys Asn Thr Asn Ser Ala Ala Lys Ser His Ile 370 375 380 Val Gly Lys Val Tyr Leu His Gly Glu Val Ser Lys Pro Leu Asp Leu 385 390 395 400 Ile Ile Thr Phe Asn Glu Thr Ser Asn Glu Thr Cys Thr Tyr Cys Ile 405 410 415 Asn Phe Gln Trp Gln Trp Gly Thr Asp Lys Tyr Lys Asn Glu Thr Leu 420 425 430 Ala Val Ser Ser Phe Thr Phe Ser Tyr Ile Ala Gln Glu 435 440 445 <210> 70 <211> 31920 <212> DNA <213> Unknown <220> <223> Simian adenovirus A1331 <220> <221> CDS <222> (1906)..(3414) <223> E1b\55K <220> <221> CDS <222> (25586)..(26131) <223> 22K <220> <221> CDS <222> (27432)..(28055) <223> E3\CR1-alpha <220> <221> CDS <222> (31511)..(31915) <223> E3\14.7K <400> 70 cwwymtmwat aatatacctc aaacttttgg tgcgcgttaa tatgcaaatg agccgtttga 60 atttggggat ggaggaaggt gattggctgt gggagcggcg accgttaggg gcggggcggg 120 tgacgttttg atgacgtggc catgaggcgg agccggtttg caagttctcg tgggaaaagt 180 gacgtcaaac gaggtgtggt ttgaacacgg aaatactcaa ttttcccgcg ctctctgaca 240 ggaaatgagg tgtttctggg cggatgcaag tgaaaacggg ccattttcgc gcgaaaactg 300 aatgaggaag tgaaaatctg agtaattccg cgtttatggc agggaggagt atttgccgag 360 ggccgagtag actttgaccg attacgtggg ggtttcgatt accgtatttt tcacctaaat 420 ttccgcgtac ggtgtcaaag tccggtgttt ttacgtaggt gtcagctgat cgccagggta 480 tttaaacctg cgctctctag tcaagaggcc actcttgagt gccagcgagt agagttttct 540 cctccgcgcc gcgagtcaga tctacacttt gaaagatgag gcacctgaga gacctgcccg 600 gtaatgtttt cctggctact gggaacgaga ttctggaact ggtggtggac gccatgatgg 660 gtgacgaccc tcccgagccc cctaccccat ttgaggcgcc ttcgctgtac gatttgtatg 720 atctggaggt ggatgtgtcc gagaacgacc ccaacgagga ggcggtgaat gatttgttta 780 gcgatgccgc gctgctggct gccgagcagg ctaatacgga ctctggctca gacagcgatt 840 cctctctcca taccccgaga cccggcagag gtgagaaaaa gatccccgag cttaaagggg 900 aagagctcga cctgcgctgc tatgaggaat gcttgcctcc gagcgatgat gaggaggacg 960 aggaggcgat tcgagctgca gcgagcgagg gagtgaaagt tgcgggcgag agctttagcc 1020 tggactgtcc tactctgccc ggacacggct gtaagtcttg tgaatttcat cgcatgaata 1080 ctggagataa gaatgtgatg tgtgccctgt gctatatgag agcttacaac cattgtgttt 1140 acagtaagtg tgattaactt tagttgggaa aggcagaggg tgactgggtg ctgactggtt 1200 tatttatgta tatgtttttt atgtgtaggt cccgtctctg acgcagatga gacccccact 1260 tcagagtgca tttcatcacc cccagaaatt ggcgaggaac cgcccgaaga tattattcat 1320 agaccagttg cagtgagagt caccgggcgg agagcagctg tggagagttt ggatgacttg 1380 ctacagggtg gggatgaacc tttggacttg tgtacccgga aacgccccag gcactaagtg 1440 ccacacatgt gtgtttactt aaggtgatgt cagtatttat agggtgtgga gtgcaataaa 1500 aatatgtgtt gactttaagt gcgtgtttta tgactcaggg gtggggactg tgggtatata 1560 agcaggtgca gacctgtgtg gtcagttcag agcaggactc atggagatct ggacagtctt 1620 ggaagacttt caccagacta gacagctgct agagaactca tcggagggag tctcttacct 1680 gtggagattc tgcttcgctg ggcctctagc taagctagtc tatagggcca agcaggatta 1740 tagggaacaa tttgaggata ttttgagaga gtgtcctggt atttttgact ctctcaactt 1800 gggccatcag tctcacttta accagagtat tctgagagcc cttgactttt ctactcctgg 1860 cagaactacc gccgcggtag ccttttttgc ctttatcctt gacaa atg gag tca aga 1917 Met Glu Ser Arg 1 aac cca ttt cag cag gga tta ccg tct gga ctg ctt agc agt agc ttt 1965 Asn Pro Phe Gln Gln Gly Leu Pro Ser Gly Leu Leu Ser Ser Ser Phe 5 10 15 20 gtg gag aac atg gag gtg cca gcg cct gaa tgc aat ctc cgg cta ctt 2013 Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn Leu Arg Leu Leu 25 30 35 gcc agt aca gcc ggt aga cac gct gag gat cct gag tct cca gtc acc 2061 Ala Ser Thr Ala Gly Arg His Ala Glu Asp Pro Glu Ser Pro Val Thr 40 45 50 cca gga aca cca acg ccg cca gca gcc gca gca gga gca gca gca aga 2109 Pro Gly Thr Pro Thr Pro Pro Ala Ala Ala Ala Gly Ala Ala Ala Arg 55 60 65 gga gga gga ccg aga aga gaa ccc gag agc cgg tct gga ccc tcc ggt 2157 Gly Gly Gly Pro Arg Arg Glu Pro Glu Ser Arg Ser Gly Pro Ser Gly 70 75 80 ggc gga gga gga gga gta gct gac ttg ttt ccc gag ctg cgc cgg gtg 2205 Gly Gly Gly Gly Gly Val Ala Asp Leu Phe Pro Glu Leu Arg Arg Val 85 90 95 100 ctg act agg tct tcc agt gga cgg gag agg ggg att aag cgg gag agg 2253 Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly Ile Lys Arg Glu Arg 105 110 115 cat gag gag act agc cac aga act gaa ctg act gtc agt ctg atg agc 2301 His Glu Glu Thr Ser His Arg Thr Glu Leu Thr Val Ser Leu Met Ser 120 125 130 cgc agg cgc cca gaa tcg gtg tgg tgg cat gag gtt cag tcg cag ggg 2349 Arg Arg Arg Pro Glu Ser Val Trp Trp His Glu Val Gln Ser Gln Gly 135 140 145 gta gat gag gtc tcg gtg atg cat gag aaa tat tcc cta gaa caa gtc 2397 Val Asp Glu Val Ser Val Met His Glu Lys Tyr Ser Leu Glu Gln Val 150 155 160 aag act tgt tgg ttg gag ccc gag gat gat tgg gag gta gcc atc agg 2445 Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp Glu Val Ala Ile Arg 165 170 175 180 aat tat gcc aag ctg gct ctg agg cca gac aag aag tac aag att acc 2493 Asn Tyr Ala Lys Leu Ala Leu Arg Pro Asp Lys Lys Tyr Lys Ile Thr 185 190 195 aaa ctg att aat atc aga aat tcc tgc tac att tca ggg aat ggg gcc 2541 Lys Leu Ile Asn Ile Arg Asn Ser Cys Tyr Ile Ser Gly Asn Gly Ala 200 205 210 gag gtg gag atc agt acc cag gag agg gtg gct ttc aga tgc tgc atg 2589 Glu Val Glu Ile Ser Thr Gln Glu Arg Val Ala Phe Arg Cys Cys Met 215 220 225 atg aat atg tac ccg ggg gtg gtg ggc atg gag gga gtc acc ttt atg 2637 Met Asn Met Tyr Pro Gly Val Val Gly Met Glu Gly Val Thr Phe Met 230 235 240 aac gcg agg ttc agg ggt gat ggg tat aat ggg gtg gtc ttt atg gcc 2685 Asn Ala Arg Phe Arg Gly Asp Gly Tyr Asn Gly Val Val Phe Met Ala 245 250 255 260 aac acc aag ctg aca gtg cac gga tgc tcc ttc ttt ggc ttc aat aac 2733 Asn Thr Lys Leu Thr Val His Gly Cys Ser Phe Phe Gly Phe Asn Asn 265 270 275 atg tgc atc gag gcc tgg ggc agt gtt tca gtg agg gga tgc agc ttt 2781 Met Cys Ile Glu Ala Trp Gly Ser Val Ser Val Arg Gly Cys Ser Phe 280 285 290 tca gcc aac tgg atg ggg gtc gtg ggc aga acc aag agc aag gtg tca 2829 Ser Ala Asn Trp Met Gly Val Val Gly Arg Thr Lys Ser Lys Val Ser 295 300 305 gtg aag aaa tgc ctg ttc gag agg tgc cac ctg ggg gtg atg agc gag 2877 Val Lys Lys Cys Leu Phe Glu Arg Cys His Leu Gly Val Met Ser Glu 310 315 320 ggc gaa gcc aaa gtc aaa cac tgc gcc tct acc gag acg ggc tgc ttt 2925 Gly Glu Ala Lys Val Lys His Cys Ala Ser Thr Glu Thr Gly Cys Phe 325 330 335 340 gtg tgt atc aag ggc aat gcc caa gtc aag cat aac atg atc tgt ggg 2973 Val Cys Ile Lys Gly Asn Ala Gln Val Lys His Asn Met Ile Cys Gly 345 350 355 gcc tcg gat gag cgc ggc tac cag atg ctg acc tgc gcc ggt ggg aac 3021 Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr Cys Ala Gly Gly Asn 360 365 370 agc cat atg ctg gcc acc gtg cat gtg gcc tcg cac ccc cgc aag aca 3069 Ser His Met Leu Ala Thr Val His Val Ala Ser His Pro Arg Lys Thr 375 380 385 tgg ccc gag ttc gag cac aac gtc atg acc cgc tgc aat gtg cac ctg 3117 Trp Pro Glu Phe Glu His Asn Val Met Thr Arg Cys Asn Val His Leu 390 395 400 ggc tcc cgc cga ggc atg ttc atg cca tac cag tgc aac atg caa ttt 3165 Gly Ser Arg Arg Gly Met Phe Met Pro Tyr Gln Cys Asn Met Gln Phe 405 410 415 420 gtg aag gtg ctg ctg gag ccc gat gcc atg tcc aga gtg agc ctg gcg 3213 Val Lys Val Leu Leu Glu Pro Asp Ala Met Ser Arg Val Ser Leu Ala 425 430 435 ggg gtg ttt gac atg aat gtg gag ctg tgg aaa att ctg aga tat gat 3261 Gly Val Phe Asp Met Asn Val Glu Leu Trp Lys Ile Leu Arg Tyr Asp 440 445 450 gaa tcc aag acc agg tgc cgg gcc tgc gaa tgc gga ggc aag cac gcc 3309 Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys Gly Gly Lys His Ala 455 460 465 agg ctt cag ccc gtg tgt gtg gag gtg acg gag gac ctg cga ccc gat 3357 Arg Leu Gln Pro Val Cys Val Glu Val Thr Glu Asp Leu Arg Pro Asp 470 475 480 cat ttg gtg ttg tcc tgc aac ggg acg gag ttc ggc tcc agc ggg gaa 3405 His Leu Val Leu Ser Cys Asn Gly Thr Glu Phe Gly Ser Ser Gly Glu 485 490 495 500 gaa tct gac tagagtgagt agtgtttggg ggcgggtggg agcctgcatg 3454 Glu Ser Asp aggggcagaa tgactaaaat ctgtgttttt ctgtgcagca gcatgagcgg aagcgcctcc 3514 tttgagggag gggtattcag cccttatctg acggggcgtc tcccctcctg ggcgggagtg 3574 cgtcagaatg tgatgggatc tacggtggac ggccggcccg tgcagcccgc gaactcttca 3634 accctgacct acgcgaccct gagctcctcg tccgtggacg cagctgccgc cgcagctgct 3694 gcttccgccg ccagcgccgt gcgcggaatg gccctgggcg ccggctacta cagctctctg 3754 gtggccaact cgagttccac caataatccc gccagcctga acgaggagaa gctgctgctg 3814 ctgatggccc agctcgaggc cctgacccag cgcctgggcg agctgaccca gcaggtggct 3874 cagctgcagg cggagacgcg ggccgcggtt gccacggtga aaaccaaata aaaaatgaat 3934 caataaataa acggagacgg ttgttgattt taacacagag tcttgaatct ttatttgatt 3994 tttcgcgcgc ggtaggccct ggaccaccgg tctcgatcat tgagcacccg gtggatcttt 4054 tccaggaccc ggtagaggtg ggcttggatg ttgaggtaca tgggcatgag cccgtcccgg 4114 gggtggaggt agctccattg cagggcctcg tgctcggggg tggtgttgta aatcacccag 4174 tcatagcagg ggcgcagtgc gtggtgctgc acgatgtcct tgaggaggag actgatggcc 4234 acgggcagcc ccttggtgta ggtgttgacg aacctgttga gctgggaggg atgcatgcgg 4294 ggggagatga gatgcatctt ggcctggatc ttgagattgg cgatgttccc gcccagatcc 4354 cgccgggggt tcatgttgtg caggaccacc agcacggtgt atccggtgca cttggggaat 4414 ttgtcatgca acttggaagg gaaggcgtga aagaatttgg agacgccctt gtgaccgccc 4474 aggttttcca tgcactcatc catgatgatg gcgatgggcc cgtgggcggc ggcctgggca 4534 aagacgtttc gggggtcgga cacatcgtag ttgtggtcct gggtgagctc gtcataggcc 4594 attttaatga atttggggcg gagggtgccc gactggggga cgaaggtgcc ttcgatcccg 4654 ggggcgtagt tgccctcgca gatctgcatc tcccaggcct tgagctcgga gggggggatc 4714 atgtccacct gcggggcgat gaaaaaaacg gtttccgggg cgggggagat gagctgcgcc 4774 gaaagcaggt tccggagcag ctgggacttg ccgcagccgg tggggccgta gatgaccccg 4834 atgaccggct gcaggtggta gttgagggag agacagctgc cgtcctcgcg taggaggggg 4894 gccacctcgt tcatcatctc gcgcacatgc atgttctcgc gcacgagttc cgccaggagg 4954 cgctcgcccc ccagcgagag gagctcttgc agcgaggcga agtttttcag cggcttgagc 5014 ccgtcggcca tgggcatttt ggagagggtc tgttgcaaga gttccagacg gtcccagagc 5074 tcggtgatgt gctctacggc atctcgatcc agcagacctc ctcgtttcgc gggttgggac 5134 gactgcggga gtagggcacc agacgatggg cgtccagcgc agccagggtc cggtccttcc 5194 agggtcgcag cgtccgcgtc agcgtggtct ccgtcacggt gaaggggtgc gcgccgggct 5254 gggcgcttgc gagggtgcgc ttcaggctca tccggctggt cgagaaccgc tcccgatcgg 5314 cgccctgcgc gtcggccagg tagcaattga ccatgagttc gtagttgagc gcctcggccg 5374 cgtggccttt ggcgcggagc ttacctttgg aagtctgccc gcaggcggga cagaggaggg 5434 acttgagggc gtagagcttg ggggcgagga agacggactc gggggcgtag gcgtccgcgc 5494 cgcagtgggc gcagacggtc tcgcactcca caagccaggt gaggtcgggc tggtcggggt 5554 caaaaaccag ttttccgccg ttctttttga tgcgtttctt acctttggtc tccatgagct 5614 cgtgtccccg ctgggtgaca aagaggctgt ccgtgtcccc gtagaccgac tttatgggcc 5674 ggtcctcgag cggtgtgcca cggtcctcct cgtagaggaa ccccgcccac tccgagacga 5734 aagcccgggt ccaggccagc acgaaggagg ccacgtggga cgggtagcgg tcgttgtcca 5794 ccagcgggtc cactttctcc agggtatgca aacacatgtc cccctcgtcc acatccagga 5854 aggtgattgg cttgtaagtg taggccacgt gaccgggggt cccggccggg ggggtataaa 5914 agggggcggg cccctgctcg tcctcactgt cttccggatc gctgtccagg agcgccagct 5974 gttggggtag gtattccctc tcgaaggcgg gcatgacctc ggcactcagg ttgtcagttt 6034 ctagaaacga ggaggatttg atattgacgg tgccgttgga gacgcctttc atgagcccct 6094 cgtccatctg gtcagaaaag acgatctttt tgttgtcgag cttggtggcg aaggagccgt 6154 agagggcgtt ggagagcagc ttggcgatgg agcgcatggt ctggttcttt tccttgtcgg 6214 cgcgctcctt ggcggcgatg ttgagctgca cgtactcgcg cgccacgcac ttccattcgg 6274 ggaagacggt ggtgagctcg tcgggcacga ttctgacccg ccagccgcgg ttgtgcaggg 6334 tgatgaggtc cacgctggtg gccacctcgc cgcgcagggg ctcgttggtc cagcagaggc 6394 gcccgccctt gcgcgagcag aaggggggca gcgggtccag catgagctcg tcgggggggt 6454 cggcgtccac ggtgaagatg ccgggcagga gctcggggtc gaagtagctg atgcaggtgc 6514 ccagatcgtc cagcgccgct tgccagtcgc gcacggccag cgcgcgctcg taggggctga 6574 ggggcgtgcc ccagggcatg gggtgcgtga gcgcggaggc gtacatgccg cagatgtcgt 6634 agacgtagag gggctcctcg aggacgccga tgtaggtggg gtagcagcgc cccccgcgga 6694 tgctggcgcg cacgtagtcg tacagctcgt gcgagggcgc gaggagcccc gcgccgaggt 6754 tggagcgctg cggcttttcg gcgcggtaga cgatctggcg gaagatggcg tgggagttgg 6814 aggagatggt gggcctctgg aagatgttga agtgggcgtg gggcaggccg accgagtccc 6874 tgatgaagtg ggcgtaggag tcctgcagct tggcgacgag ctcggcggtg acgaggacgt 6934 ccagggcgca gtagtcgagg gtctcttgga tgatgtcgta cttgagctgg cccttctgct 6994 tccacagctc gcggttgaga aggaactctt cgcggtcctt ccagtactct tcgaggggga 7054 acccgtcctg atcggcacgg taagagccca ccatgtagaa ctggttgacg gccttgtagg 7114 cgcagcagcc cttctccacg gggagggcgt aagcttgcgc ggccttgcgc agggaggtgt 7174 gggtgagggc gaaggtgtcg cgcaccatga ccttgaggaa ctggtgcttg aagtcgaggt 7234 cgtcgcagcc gccctgctcc cagagttgga agtccgtgcg cttcttgtag gcggggttgg 7294 gcaaagcgaa agtaacatcg ttgaagagga tcttgcccgc gcggggcatg aagttgcgag 7354 tgatgcggaa aggctggggc acctcggccc ggttgttgat gacctgggcg gcgaggacga 7414 tctcgtcgaa gccgttgatg ttgtgcccga cgatgtagag ttccacgaat cgcgggcggc 7474 ccttgacgtg gggcagcttc ttgagctcgt cgtaggtgag ctcggcgggg tcgctgagcc 7534 cgtgctgctc aagggcccag tcggcgacgt gggggttggc gctgaggaag gaagtccaga 7594 gatccacggc cagggcggtt tgcaagcggt cccggtactg acggaactgc tggcccacgg 7654 ccattttttc gggggtgatg cagtagaagg tgcgggggtc gccgtgccag cggtcccact 7714 tgagctggag ggcgaggtcg tgggcgagct cgacgagcgg cgggtccccg gagagtttca 7774 tgaccagcat gaaggggacg agctgcttgc cgaaggaccc catccaggtg taggtttcca 7834 catcgtaggt gaggaagagc ctttcggtgc gaggatgcga gccgatgggg aagaactgga 7894 tctcctgcca ccagttggag gaatggctgt tgatgtgatg gaagtagaaa tgccgacggc 7954 gcgccgagca ctcgtgcttg tgtttataca agcgtccgca gtgctcgcaa cgctgcacgg 8014 gatgcacgtg ctgcacgagc tgtacctggg ttcctttgac gaggaatttc agtgggcagt 8074 ggagcgctgg cggctgcatc tggtgctgta ctacgtcctg gccatcggcg tggccatcgt 8134 ctgcctcgat ggtggtcatg ctgacgagcc cgcgcgggag gcaggtccag acctcggctc 8194 ggacgggtcg gagagcgagg acgagggcgc gcaggccgga gctgtccagg gtcctgagac 8254 gctgcggagt caggtcagtg ggcagcggcg gcgcgcggtt gacttgcagg agcttttcca 8314 gggcgcgcgg gaggtccaga tggtacttga tctccacggc gccgttggtg gcgacgtcca 8374 cggcttgcag ggtcccgtgc ccctggggcg ccaccaccgt gccccgtttc ttcttgggcg 8434 ctggcgttgg cgctgcttcc atgtcggtca gaagcggcgg cgaggacgcg cgccgggcgg 8494 caggggcggc tcggggcccg gaggcagggg cggcaggggc acgtcggcgc cgcgcgcggg 8554 caggttctgg tactgcgccc ggagaagact ggcgtgagcg acgacgcgac ggttgacgtc 8614 ctggatctga cgcctctggg tgaaggccac gggacccgtg agtttgaacc tgaaagagag 8674 ttcgacagaa tcaatctcgg tatcgttgac ggcggcctgc cgcaggatct cttgcacgtc 8734 gcccgagttg tcctggtagg cgatctcggt catgaactgc tcgatctcct cctcctgaag 8794 gtctccgcgg ccggcgcgct cgacggtggc cgcgaggtcg ttggagatgc ggcccatgag 8854 ctgcgagaag gcgttcatgc cggcctcgtt ccagacgcgg ctgtagacca cggatccgtc 8914 ggggtcgcgc gcgcgcatga ccacctgggc gaggttgagc tccacgtggc gcgtgaagac 8974 cgcgtagttg cagaggcgct ggtagaggta gttgagcgtg gtggcgatgt gctcggtgac 9034 gaagaagtac atgatccagc ggcggagcgg catctcgctg acgtcgccca gggcttccaa 9094 gcgctccatg gcctcgtaga agtccacggc gaagttgaaa aactgggagt tgcgcgccga 9154 gacggtcaac tcctcctcca gaagacggat gagctcggcg atggtggcgc gcacctcgcg 9214 ctcgaaggcc ccggggggct cctcttccat ctcctcctct tcttcctcct ccactaacat 9274 ctcttctact tcctcctcag gaggcggcgg cgggggaggg ggcctgcgtc gccggcggcg 9334 cacgggcaga cggtcgatga agcgctcgat ggtctccccg cgccggcgac gcatggtctc 9394 ggtgacggcg cgcccgtcct cgcggggccg cagcgtgaag acgccgccgc gcatctccag 9454 gtggccgccg ggggggtctc cgttgggcag ggagagggcg ctgacgatgc atcttatcaa 9514 ttgacccgta gggactccgc gcaaggacct gagcgtctcg agatccacgg gatccgaaaa 9574 ccgctgaacg aaggcttcga gccagtcgca gtcgcaaggt aggctgagcc cggtttcttc 9634 ttcggggatt tgctggtcgg gaggcgggcg ggcgatgctg ctggtgatga agttgaagta 9694 ggcggtcctg agacggcgga tggtggcgag gagcaccagg tccttgggcc cggcttgctg 9754 gatgcgcaga cggtcggcca tgccccaggc gtggtcctga cacctggcga ggtccttgta 9814 gtagtcctgc atgagccgct ccacgggcac ctcctcctcg cccgcgcggc cgtgcatgcg 9874 cgtgagcccg aacccgcgct ggggctggac gagcgccagg tcggcgacga cgcgctcggc 9934 gaggatggcc tgctggatct gggtgagggt ggtctggaag tcgtcgaagt cgacgaagcg 9994 gtggtaggct ccggtgttga tggtgtagga gcagttggcc atgacggacc agttgacggt 10054 ctggtggccg gggcgcacga gctcgtggta cttgaggcgc gagtaggcgc gcgtgtcgaa 10114 gatgtagtcg ttgcaggtgc gcacgaggta ctggtatccg acgaggaagt gaggcggcgg 10174 ctggcggtag agcggccatc gctcggtggc gggggcgccg ggcgcgaggt cttcgagcat 10234 gaggcggtgg tagccgtaga tgtacctgga catccaggtg atgccagcgg cggtggtgga 10294 ggcgcgcggg aactcgcgga cgcggttcca gatgttgcgc agcggcagga agtagttcat 10354 ggtggccgcg gtctggcccg tgaggcgcgc gcagtcgtgg atgctctaga catacgggca 10414 aaaacgaaag cggtcagcgg ctcgactccg tggcctggag gctaagcgaa cgggttgggc 10474 tgcgcgtgta ccccggttcg agtccctgct cgaatcaggc tggagccgca gctaacgtgg 10534 tactggcact cccgtctcga cccaagcctg ctaacgaaac ctccaggata cggaggcggg 10594 tcgttttttg gccttggtca ctggtcatga aaaactagta agcgcggaaa gcggccgccc 10654 gcgatggctc gctgccgtag tctggagaaa gaatcgccag ggttgcgttg cggtgtgccc 10714 cggttcgagc ctcagcgctc ggcgccggcc ggattccgcg gctaacgtgg gcgtggctgc 10774 cccgtcgttt ccaagacccc ttagccagcc gacttctcca gttacggagc gagcccctct 10834 ttttcttgtg tttttgccag atgcatcccg tactgcggca gatgcgcccc caccctccac 10894 ctcaaccgcc cctaccgcag cagcagcaac agccggcgct tttgcccccg ccccagcagc 10954 agcagcagcc agccactacc gcggcggccg ccgtgagcgg agccggcgtt caatatgacc 11014 tggccttgga agagggcgag gggctggcgc ggctgggggc gtcgtcgccg gagcggcacc 11074 cgcgcgtgca gatgaaaagg gacgctcgcg aggcctacgt gcccaagcag aacctgttca 11134 gagacaggag cggcgaggag cccgaggaga tgcgcgcctc ccgcttccac gcggggcggg 11194 agctgcggcg cggcctggac cgaaagcggg tgctgaggga cgaggatttc gaggcggacg 11254 agctgacggg gatcagcccc gcgcgcgcgc acgtggccgc ggccaacctg gtcacggcgt 11314 acgagcagac cgtgaaggag gagagcaact tccaaaaatc cttcaacaac cacgtgcgca 11374 cgctgatcgc gcgcgaggag gtgaccctgg gcctgatgca cctgtgggac ctgctggagg 11434 ccatcgtgca gaaccccacg agcaagccgc tgacggcgca gctgttcctg gtggtgcagc 11494 acagtcggga caacgagacg ttcagggagg cgctgctgaa tatcaccgag cccgagggcc 11554 gctggctcct ggacctggtg aacattctgc agagcatcgt ggtgcaggag cgcgggctgc 11614 cgctgtccga gaagctggcg gccatcaact tctcggtgct gagcctgggc aagtactacg 11674 ctaggaagat ctacaagacc ccgtacgtgc ccatagacaa ggaggtgaag atcgatgggt 11734 tttacatgcg catgaccctg aaagtgctga ccctgagcga cgatctgggg gtgtaccgca 11794 acgacaggat gcaccgcgcg gtgagcgcca gccgccggcg cgagctgagc gaccaggagc 11854 tgatgcacag cctgcagcgg gccctgaccg gggccgggac cgagggggag agctactttg 11914 acatgggcgc ggacctgcgc tggcagccca gccgccgggc cttggaagct gccggcggcg 11974 tgccctacgt ggaggaggtg gacgatgagg aggaggaggg cgagtacctg gaagactgat 12034 ggcgcgaccg tatttttgct agatgcagca acagccaccg cctcctgatc ccgcgatgcg 12094 ggcggcgctg cagagccagc cgtccggcat taactcctcg gacgattgga cccaggccat 12154 gcaacgcatc atggcgctga cgacccgcaa tcccgaagcc tttagacagc agcctcaggc 12214 caaccggctc tcggccatcc tggaggccgt ggtgccctcg cgctcgaacc ccacgcacga 12274 gaaggtgctg gccatcgtga acgcgctggt ggagaacaag gccatccgcg gcgacgaggc 12334 cgggctggtg tacaacgcgc tgctggagcg cgtggcccgc tacaacagca ccaacgtgca 12394 gacgaacctg gaccgcatgg tgaccgacgt gcgcgaggcg gtgtcgcagc gcgagcggtt 12454 ccaccgcgag tcgaacctgg gctccatggt ggcgctgaac gccttcctga gcacgcagcc 12514 cgccaacgtg ccccggggcc aggaggacta caccaacttc atcagcgcgc tgcggctgat 12574 ggtggccgag gtgccccaga gcgaggtgta ccagtcgggg ccggactact tcttccagac 12634 cagtcgccag ggcttgcaga ccgtgaacct gagccaggct ttcaagaact tgcagggact 12694 gtggggcgtg caggccccgg tcggggaccg cgcgacggtg tcgagcctgc tgacgccgaa 12754 ctcgcgcctg ctgctgctgc tggtggcgcc cttcacggac agcggcagcg tgagccgcga 12814 ctcgtacctg ggctacctgc ttaacctgta ccgcgaggcc atcgggcagg cgcacgtgga 12874 cgagcagacc taccaggaga tcacccacgt gagccgcgcg ctgggccagg aggacccggg 12934 caacctggag gccaccctga acttcctgct gaccaaccgg tcgcagaaga tcccgcccca 12994 gtacgcgctg agcaccgagg aggagcgcat cctgcgctac gtgcagcaga gcgtggggct 13054 gttcctgatg caggaggggg ccacgcccag cgccgcgctc gacatgaccg cgcgcaacat 13114 ggagcccagc atgtacgccc gcaaccgccc gttcatcaat aagctgatgg actacttgca 13174 tcgggcggcc gccatgaact cggactactt taccaacgcc atcttgaacc cgcactggct 13234 cccgccgccc gggttctaca cgggcgagta cgacatgccc gaccccaacg acgggttcct 13294 gtgggacgac gtggacagca gcgtgttctc gccgcgcccc accaccaccg tgtggaagaa 13354 agagggcggg gaccggcggc cgtcctcggc gctgtccggt cgcgcgggtg ctgccgcggc 13414 ggtgcccgag gccgccagcc ccttcccgag cctgcccttt tcgctgaaca gcgtgcgcag 13474 cagcgatctg ggtcggctga cgcggccgcg cctgctgggc gaggaggagt acctgaacga 13534 ctccttgttg aggcccgagc gcgagaaaaa cttccccaat aacgggatag agagcctggt 13594 ggacaagatg agccgctgga agacgtacgc gcacgagcac agggacgagc cccgagctag 13654 cagcagcacc ggcgcccgta gacgccagcg gcacgacagg cagcggggac tggtgtggga 13714 cgatgaggat tccgccgacg acagcagcgt gttggacttg ggtgggagtg gtggtggtaa 13774 cccgttcgct cacctgcgcc cccgtatcgg gcgcctgatg taagaatctg aaaaaataaa 13834 aaaacggtac tcaccaaggc catggcgacc agcgtgcgtt cttctctgtt gtttgtagta 13894 gtatgatgag gcgcgtgtac ccggagggtc ctcctccctc gtacgagagc gtgatgcagc 13954 aggcggtggc ggcggcgatg cagcccccgc tggaggcgcc ttacgtgccc ccgcggtacc 14014 tggcgcctac ggaggggcgg aacagcattc gttactcgga gctggcaccc ttgtacgata 14074 ccacccggtt gtacctggtg gacaacaagt cggcggacat cgcctcgctg aactaccaga 14134 acgaccacag caacttcctg accaccgtgg tgcagaacaa cgatttcacc cccacggagg 14194 ccagcaccca gaccatcaac tttgacgagc gctcgcggtg gggcggccag ctgaaaacca 14254 tcatgcacac caacatgccc aacgtgaacg agttcatgta cagcaacaag ttcaaggcgc 14314 gggtgatggt ctcgcgcaag acccccaacg gggtcacagt aacagatggt agtcaggacg 14374 agctgaccta cgagtgggtg gagtttgagc tgcccgaggg caacttctcg gtgaccatga 14434 ccatcgatct gatgaacaac gccatcatcg acaactactt ggcggtggga cggcagaacg 14494 gggtgctgga gagcgacatc ggcgtgaagt tcgacacgcg caacttccgg ctgggctggg 14554 accccgtgac cgagctggtg atgccgggcg tgtacaccaa cgaggccttc caccccgaca 14614 tcgtcctgct gcccggctgc ggcgtggact tcaccgagag ccgcctcagc aacctgctgg 14674 gcatccgcaa gcggcagccc ttccaggagg gcttccagat cctgtacgag gacctggagg 14734 ggggcaacat ccccgcgctg ctggacgtcg aagcctacga gaaaagcaag gaggaggccg 14794 ccgcagcggc gaccgcggcc gtggctaccg ctgcgaccac cgatgcagat gcagctacta 14854 ctaccagggg cgatacattc gccacccagg cggaggaagc agccgcccta gcggcgaccg 14914 atgatagtga aagtaagata gtcatcaagc cggtggagaa ggacagcaag gacaggagct 14974 acaacgttct atcggatgga aagaacaccg cctaccgcag ctggtacctg gcctacaact 15034 acggcgaccc tgagaagggc gtgcgctcct ggacgctgct caccacctcg gacgtcacct 15094 gcggcgtgga gcaagtctac tggtcgctgc ccgacatgat gcaagacccg gtcaccttcc 15154 gctccacgcg tcaagttagc aactacccgg tggtgggcgc cgagctcctg cccgtctact 15214 ccaagagctt cttcaacgag caggccgtct actcgcagca gctgcgcgcc ttcacctcgc 15274 tcacgcacgt cttcaaccgc ttccccgaga accagatcct cgtccgcccg cccgcgccca 15334 ccattaccac cgtcagtgaa aacgttcctg ctctcacaga tcacgggacc ctgccgctgc 15394 gcagcagtat ccggggagtc cagcgcgtga ccgtcactga cgccagacgc cgcacctgcc 15454 cctacgtcta caaggccctg ggcgtagtcg cgccgcgcgt cctctcgagc cgcaccttct 15514 aaaaaatgtc cattctcatc tcgcccagta ataacaccgg ttggggcctg cgcgcgccca 15574 gcaagatgta cggaggcgct cgccaacgct ccacgcaaca ccccgtgcgc gtgcgcgggc 15634 acttccgcgc tccctggggc gccctcaagg gccgcgtgcg ctcgcgcacc accgtcgacg 15694 acgtgatcga ccaggtggtg gccgacgcgc gcaactacac gcccgccgcc gcgcccgcct 15754 ccaccgtgga cgccgtcatc gacagcgtgg tggccgacgc gcgccggtac gcccgcgcca 15814 agagccggcg gcggcgcatc gcccggcggc accggagcac ccccgccatg cgcgcggcgc 15874 gagccttgct gcgcagggcc aggcgcacgg gacgcagggc catgctcagg gcggccagac 15934 gcgcggcctc cggcagcagc agcgccggca ggacccgcag acgcgcggcc acggcggcgg 15994 cggcggccat cgccagcatg tcccgcccgc ggcgcggcaa cgtgtactgg gtgcgcgacg 16054 ccgccaccgg tgtgcgcgtg cccgtgcgca cccgcccccc tcgcacttga agatgctgac 16114 ttcgcgatgt tgatgtgtcc cagcggcgag gaggatgtcc aagcgcaaat tcaaggaaga 16174 gatgctccag gtcatcgcgc ctgagatcta cggccccgcg gcggcggtga aggaggaaag 16234 aaagccccgc aaactgaagc gggtcaaaaa ggacaaaaag gaggaggaag atgacggact 16294 ggtggagttt gtgcgcgagt tcgccccccg gcggcgcgtg cagtggcgcg ggcggaaagt 16354 gaaaccggtg ctgcggcccg gcaccacggt ggtcttcacg cccggcgagc gttccggctc 16414 cgcctccaag cgctcctacg acgaggtgta cggggacgag gacatcctcg agcaggcggc 16474 agagcgtctg ggcgagtttg cttacggcaa gcgcagccgc cccgcgccct tgaaagagga 16534 ggcggtgtcc atcccgctgg accacggcaa ccccacgccg agcctgaagc cggtgaccct 16594 gcagcaggtg ctgccgagcg cggcgccgcg ccggggcttc aagcgcgagg gcggcgagga 16654 tctgtacccg accatgcagc tgatggtgcc caagcgccag aagctggagg acgtgctgga 16714 gcacatgaag gtggaccccg aggtgcagcc cgaggtcaag gtgcggccca tcaagcaggt 16774 ggccccgggc ctgggcgtgc agaccgtgga catcaagatc cccacggagc ccatggaaac 16834 gcagaccgag cccgtgaagc ccagcaccag caccatggag gtgcagacgg atccctggat 16894 gccggcgccg gcttccacca ccactcgccg aagacgcaag tacggcgcgg ccagcctgct 16954 gatgcccaac tacgcgctgc atccttccat catccccacg ccgggctacc gcggcacgcg 17014 cttctaccgc ggctacagca gccgccgcaa gaccaccacc cgccgccgcc gtcgccgcac 17074 ccgccgcagc accaccgcga cttccgccgc cgccttggtg cggagagtgt accgcagcgg 17134 gcgtgagcct ctgaccctgc cgcgcgcgcg ctaccacccg agcatcgcca tttaactctg 17194 ccgtcgcctc cttgcagata tggccctcac atgccgcctc cgcgtcccca ttacgggcta 17254 ccgaggaaga aagccgcgcc gtagaaggct gacggggaac gggctgcgtc gccatcacca 17314 ccggcggcgg cgcgccatca gcaagcggtt ggggggaggc ttcctgcccg cgctgatccc 17374 catcatcgcc gcggcgatcg gggcgatccc cggcatagct tccgtggcgg tgcaggcctc 17434 tcagcgccac tgagacacag cttggaaaat ttgtaataaa aaaatggact gacgctcctg 17494 gtcctgtgat gtgtgttttt agatggaaga catcaatttt tcgtccctgg caccgcgaca 17554 cggcacgcgg ccgtttatgg gcacctggag cgacatcggc aacagccaac tgaacggggg 17614 cgccttcaat tggagcagtc tctggagcgg gcttaagaat ttcgggtcca cgctcaaaac 17674 ctatggcaac aaggcgtgga acagcagcac agggcaggcg ctgagggaaa agctgaaaga 17734 gcagaacttc cagcagaagg tggtcgatgg cctggcctcg ggcatcaacg gggtggtgga 17794 cctggccaac caggccgtgc agaaacagat caacagccgc ctggacgcgg tcccgcccgc 17854 ggggtccgtg gagatgcccc aggtggagga ggagctgcct cccctggaca agcgcggcga 17914 caagcgaccg cgtcccgacg cggaggagac gctgctgacg cacacggacg agccgccccc 17974 gtacgaggag gcggtgaaac tgggtctgcc caccacgcgg cccatcgcgc ccctggccac 18034 cggggtgctg aaacccgagt ctaagcccgc gaccctggac ttgcctcctc ccccgacctc 18094 ccgcccctcc acagtggcta agcccctgcc gccggtggcc cgcgcgcgac ccgggagccg 18154 cccgcaggcg aactggcaga gcactctgaa cagcatcgtg ggtctgggag tgcagagtgt 18214 gaagcgccgc cgctgctatt aaacataccg tagcgcttaa cttgcttgtc tgtgtgtgta 18274 tgtattatgt cgccgccgct gtccagaagg aggagtgaag aggcgcgtcg ccgagttgca 18334 agatggccac cccatcgatg ctgccccagt gggcgtacat gcacatcgcc ggacaggacg 18394 cttcggagta cctgagtccg ggtctggtgc agttcgcccg cgccacagac acctacttca 18454 gtctggggaa caagtttagg aaccccacgg tggcgcccac gcacgatgtg accaccgacc 18514 gcagccagcg gctgacgctg cgcttcgtgc ccgtggaccg cgaggacaac acctactcgt 18574 acaaagtgcg ctacacgctg gccgtgggcg acaaccgcgt gctggacatg gccagcacct 18634 actttgacat ccgcggcgtg ctggaccggg gccctagctt caaaccctac tccggcaccg 18694 cctacaacag cctggccccc aagggagctc ccaattccag tcagtgggag cagacggaga 18754 acgggggcgg acaggctacg actaaaacac acacctatgg agttgcccca atgggtggaa 18814 ctaatattac agtcgacgga ctacaaattg gaactgacgc tacagctgat acggaaaaac 18874 caatttatgc tgataaaaca ttccaacctg agcctcagat aggagaggaa aactggcaag 18934 aaactgaaag cttttatggc ggtagggctc ttaagaaaga cacaaacatg aagccttgtt 18994 atggctcatt tgccagacct accaatgaaa agggaggtca agctaaactt aaagttggag 19054 ctgatgggct gccgaccaaa gaatttgaca tagacctagc attctttgat actcctggtg 19114 gcactgtgac cggaggtaca gaggagtata aagcagatat tgttatgtat accgaaaaca 19174 cgtatctgga aactccagac acacatgtgg tgtataaacc aggcaaggat aacacaagtt 19234 ctaaaattaa cctggtccag cagtctatgc ccaacaggcc caactacatt gggtttaggg 19294 acaactttat tgggctcatg tattacaaca gcactggcaa tatgggtgtg ctggccggtc 19354 aggcttctca gttgaatgct gtggttgact tgcaagacag aaacactgaa ctgtcttacc 19414 agctcttgct tgactctttg ggtgacagaa ccaggtattt cagtatgtgg aatcaggcgg 19474 tggacagtta tgatcctgat gtgcgcatta ttgaaaacca tggtgtggaa gatgaacttc 19534 ccaactattg cttccccctg gatgggtctg gcactaacgc cgcttaccaa ggtgtgaaag 19594 taaaaaatgg tcaagatggt gatgttgaga gcgaatggga aaaagatgat actgtcgcag 19654 ctcgaaatca attatgcaag ggcaacattt ttgccatgga gatcaatctc caggccaacc 19714 tgtggagaag ttttctctac tcgaacgtgg ccctgtacct gcccgattct tacaagtaca 19774 cgccggccaa catcaccctg cccaccaaca ccaacaccta cgattacatg aacgggagag 19834 tggtgcctcc ctcgctggtg gacgcctaca tcaacatcgg ggcgcgctgg tcgctggacc 19894 ccatggacaa cgtcaatccc ttcaaccacc atcgcaacgc ggggctgcgc taccgctcca 19954 tgctcctggg caacgggcgc tacgtgccct tccacatcca ggtgccccag aaatttttcg 20014 ccattaagag cctcctgctc ctgcccgggt cctacaccta cgagtggaac ttccgcaagg 20074 acgtcaacat gatcctgcag agctccctcg gcaacgacct gcgcacggac ggggcctcca 20134 tctccttcac cagcatcaac ctctacgcca ccttcttccc catggcgcac aacaccgcct 20194 ccacgctcga ggccatgctg cgcaacgaca ccaacgacca gtccttcaac gactacctct 20254 cggcggccaa catgctctac cccatcccgg ccaacgccac caacgtgccc atctccatcc 20314 cctcgcgcaa ctgggccgcc ttccgcggct ggtccttcac gcgcctcaag accaaggaga 20374 cgccctcgct gggctccggg ttcgacccct acttcgtcta ctcgggctcc atcccctacc 20434 tcgacggcac cttctacctc aaccacacct tcaagaaggt ctccatcacc ttcgactcct 20494 ccgtcagctg gcccggcaac gaccggctcc tgacgcccaa cgagttcgaa atcaagcgca 20554 ccgtcgacgg cgagggctac aacgtggccc agtgcaacat gaccaaggac tggttcctgg 20614 tccagatgct ggcccactac aacatcggct accagggctt ctacgtgccc gagggctaca 20674 aggaccgcat gtactccttc ttccgcaact tccagcccat gagccgccag gtggtggacg 20734 aggtcaacta caaggactac caggccgtca ccctggccta ccagcacaac aactcgggct 20794 tcgtcggcta cctcgcgccc accatgcgcc agggccagcc ctaccccgcc aactacccgt 20854 acccgctcat cggcaagagc gccgtcacca gcgtcaccca gaaaaagttc ctctgcgaca 20914 gggtcatgtg gcgcatcccc ttctccagca acttcatgtc catgggcgcg ctcaccgacc 20974 tcggccagaa catgctctat gccaactccg cccacgcgct agacatgaat ttcgaagtcg 21034 accccatgga tgagtccacc cttctctatg ttgtcttcga agtcttcgac gtcgtccgag 21094 tgcaccagcc ccaccgcggc gtcatcgagg ccgtctacct gcgcaccccc ttctcggccg 21154 gtaacgccac cacctaagct cttgcttctt gcaagatggc tgagcccacg ggctccggcg 21214 agcaggagct cagggccatc atccgcgacc tgggctgcgg gccctacttc ctgggcacct 21274 tcgataagcg cttcccggga ttcatggccc cgcacaagct ggcctgcgcc atcgtcaaca 21334 cggccggccg cgagaccggg ggcgagcact ggctggcctt cgcctggaac ccgcgctcga 21394 acacctgcta cctcttcgac cccttcgggt tctcggacga gcgcctcaag cagatctacc 21454 agttcgagta cgagggcctg ctgcgccgca gcgccctggc caccgaggac cgctgcgtca 21514 ccctggaaaa gtccacccag accgtgcagg gtccgcgctc ggccgcctgc gggctctttt 21574 gctgcatgtt cctgcacgcc ttcgtgcact ggcccgaccg ccccatggac aagaacccca 21634 ccatgaactt gctgacgggg gtgcccaacg gcatgctcca gtcgccccag gtggaaccca 21694 ccctgcgccg caaccaggag gcgctctacc gcttcctcaa cgcccactcc gcctactttc 21754 gctcccaccg cgcgcgcatc gagaaggcca ccgccttcga ccgcatgaat caagacatgt 21814 aaaccgtgtg tgtgtatgtt aaaatgtctt taataaacag cactttcatg ttacacatgc 21874 atctgagatg atttatttag aaatcgaaag ggttctgccg ggtctcggca tggcccgcgg 21934 gcagggacac gttgcggaac tggtacttgg ccagccactt gaactcgggg atcagcagtt 21994 tcggcagcgg ggtgtcgggg aaggagtcgg tccacagctt ccgcgtcagt tgcagggcgc 22054 ccagcaggtc gggcgcggag atcttgaaat cgcagttggg acccgcgttc tgcgcgcgag 22114 agttgcggta cacggggttg cagcactgga acaccatcag ggccgggtgc ttcacgctcg 22174 ccagcaccgt cgcgtcggtg atgccctcca cgtccagatc ctcggcgttg gccatcccga 22234 agggggtcat cttgcaggtc tgccgcccca tgctgggcac gcagccgggc ttgtggttgc 22294 aatcgcagtg cagggggatc agcatcatct gggcctgctc ggagctcatg cccgggtaca 22354 tggccttcat gaaagcctcc agctggcgga aggcctgctg cgccttgccg ccctcggtga 22414 agaagacccc gcaggacttg ctagagaact ggttggtagc gcagcccgcg tcgtgcacgc 22474 agcagcgcgc gtcgttgttg gccagctgca ccacgctgcg cccccagcgg ttctgggtga 22534 tcttggcccg gtcggggttc tccttcagcg cgcgctgccc gttctcgctc gccacatcca 22594 tctcgatcgt gtgctccttc tggatcatca cggtcccgtg caggcaccgc agcttgccct 22654 cggcctcggt gcagccgtgc agccacagcg cgcagccggt gctctcccag ttcttgtggg 22714 cgatctggga gtgcgagtgc acgaagccct gcaggaagcg gcccatcatc gcggtcaggg 22774 tcttgttgct ggtgaaggtc agcgggatgc cgcggtgctc ctcgttcaca tacaggtggc 22834 agatgcggcg gtacacctcg ccctgctcgg gcatcagctg gaaggcggac ttcaggtcgc 22894 tctccacgcg gtaccggtcc atcagcagcg tcatcacttc catgcccttc tcccaggccg 22954 agacgatcgg caggctcagg gggttcttca ccgccattgt catcttagtc gccgccgccg 23014 aggtcagggg gtcgttctcg tccagggtct caaacactcg cttgccgtcc ttctcgatga 23074 tgcgcacggg gggaaagctg aagcccacgg ccgccagctc ctcctcggcc tgcctttcgt 23134 cctcgctgtc ctggctgatg tcttgcaaag gcacatgctt ggtcttgcgg ggtttctttt 23194 tgggcggcag aggcggcggc gatgtgctgg gcgagcgcga gttctcgctc accacgacta 23254 tttcttctcc ttggccgtcg tccgagacca cgcggcggta ggcatgcctc ttctggggca 23314 gaggcggagg cgacgggctc tcgcggttcg gcgggcggct ggcagagccc cttccgcgtt 23374 cgggggtgcg ctcctggcgg cgctgctctg actgacttcc tccgcggccg gccattgtgt 23434 tctcctaggg agcaacaaca agcatggaga ctcagccatc gtcgccaaca tcgccatctg 23494 cccccgcctc caccgccgac gagaaccagc agcagaatga aagcttaacc gccccgccgc 23554 ccagccccac ctccgacgcc gcggccccag acatgcaaga gatggaggaa tccatcgaga 23614 ttgacctggg ctacgtgacg cccgcggagc acgaggagga gctggcagcg cgcttttcag 23674 ccccggaaga gaaccaccaa gagcagccag agcaggaagc agagaacgag cagaaccagg 23734 ctgggcacga gcatggcgac tacctgagcg gggcagagga cgtgctcatc aagcatctgg 23794 cccgccaatg catcatcgtc aaggacgcgc tgctcgaccg cgccgaggtg cccctcagcg 23854 tggcggagct cagccgcgcc tacgagcgca acctcttctc gccgcgcgtg ccccccaagc 23914 gccagcccaa cggcacctgt gagcccaacc cgcgcctcaa cttctacccg gtcttcgcgg 23974 tgcccgaggc cctggccacc taccacctct ttttcaagaa ccaaagaatc cccgtctcct 24034 gccgcgccaa ccgcacccgc gccgacgccc ttttcaacct gggccccggc gcccgcctac 24094 ctgatatcgc ctccttggaa gaggttccca agatcttcga gggtctgggc agcgacgaga 24154 ctcgggccgc gaacgctctg caaggagaag gaggagagca tgagcaccac agcgccctgg 24214 tcgagttgga aggcgacaac gcgcggctgg cggtgctcaa acgcacggtc gagctgaccc 24274 atttcgccta cccggctctg aacctgcccc ccaaagtcat gagcgccgtc atggaccagg 24334 tgctcatcaa gcgcgcgtcg cccatctccg aggacgaggg catgcaagac cccgagagca 24394 ccgaggatgg caagcccgtg gtcagcgacg agcagctggc ccggtggctg ggtcctaatg 24454 ctagtcccca gagtttggaa gagcggcgca agctcatgat ggccgtggtc ctggtgaccg 24514 tggagctgga gtgcctgcgc cgcttcttcg ccgacgcgga gaccctgcgc aaggtcgagg 24574 agaacctgca ctacctcttc aggcacgggt tcgtgcgcca ggcctgcaag atctccaacg 24634 tggagctgac caacctggtc tcctacatgg gcatcttgca cgagaaccgt ctggggcaga 24694 acgtgctgca caccaccctg cgcggggagg cccgccgcga ctacatccgc gactgcgtct 24754 acctctacct ctgccacacc tggcagacgg gcatgggcgt gtggcagcag tgcctggagg 24814 agcagaacct gaaagagctc tgcaagctcc tgcagaagaa cctcaagggt ctgtggaccg 24874 ggttcgacga gcggaccacc gcctcggatc tggccgacct catcttcccc gagcgcctca 24934 ggctgacgct gcgcaacggc ctgcccgact ttatgagcca aagcatgttg caaaactttc 24994 gctctttcat cctcgaacgc tccggaatcc tgcccgccac ctgctccgcg ctgccctcgg 25054 acttcgtgcc gctgaccttc cgcgagtgcc ccccgccgct gtggagccac tgctacctgc 25114 tgcgcctggc caactacctg gcctaccact cggacgtgat cgaggacgtc agcggcgagg 25174 gcctgctcga gtgccactgc cgctgcaacc tctgcacgcc gcaccgctcc ctggcctgca 25234 acccccagct gctgagcgag acccagatca tcggcacctt cgagttgcaa gggcccagcg 25294 atgagggttc cgccgccaag gggggtctga aactcacccc ggggctgtgg acctcggcct 25354 acttgcgcaa gttcgtgccc gaggactacc atcccttcga gatcaggttc tacgaggacc 25414 aatcccagcc gcccaaggcc gagctgtcgg cctgcgtcat cacccagggg gcgatcctgg 25474 cccaattgca agccatccag aaatcccgcc aagaattctt gctgaaaaag ggccgcgggg 25534 tctacctcga cccccagacc ggtgaggagc tcaaccccgg cttcccccag g atg ccc 25591 Met Pro 505 cga gga aac aag aag ctg aaa gtg gag ctg ccg ccc gtg gag gat ttg 25639 Arg Gly Asn Lys Lys Leu Lys Val Glu Leu Pro Pro Val Glu Asp Leu 510 515 520 gag gaa gac tgg gag aac agc agt cag gca gag gag gag gag atg gag 25687 Glu Glu Asp Trp Glu Asn Ser Ser Gln Ala Glu Glu Glu Glu Met Glu 525 530 535 gaa gac tgg gac agc act cag gca gag gag gac agc ctg caa gac agt 25735 Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser 540 545 550 ctg gag gaa gac gag gag gag gca gag gtg gaa gaa gca gcc gcc gcc 25783 Leu Glu Glu Asp Glu Glu Glu Ala Glu Val Glu Glu Ala Ala Ala Ala 555 560 565 aga ccg tcg tcc tcg gcg ggg gag aaa gca agc agc acg gat acc atc 25831 Arg Pro Ser Ser Ser Ala Gly Glu Lys Ala Ser Ser Thr Asp Thr Ile 570 575 580 585 tcc gct ccg ggt cgg ggt ccc gct cgg ccc cac agt aga tgg gac gag 25879 Ser Ala Pro Gly Arg Gly Pro Ala Arg Pro His Ser Arg Trp Asp Glu 590 595 600 acc ggg cga ttc ccg aac ccc acc acc cag acc ggt aag aag gag cgg 25927 Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys Glu Arg 605 610 615 cag gga tac aag tcc tgg cgg ggg cac aaa aac gcc atc gtc tcc tgc 25975 Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser Cys 620 625 630 ttg cag gcc tgc ggg ggc aac atc tcc ttc acc cgg cgc tac ctg ctc 26023 Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu Leu 635 640 645 ttc cac cgc ggg gtg aac ttc ccc cgc aac atc ttg cat tac tac cgt 26071 Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr Arg 650 655 660 665 cac ctc cac agc ccc tac tac ttc caa gaa gag gca gca gaa aaa gac 26119 His Leu His Ser Pro Tyr Tyr Phe Gln Glu Glu Ala Ala Glu Lys Asp 670 675 680 cag aaa acc agc tagaaaatcc acagcggcgg cagcaggtgg actgaggatc 26171 Gln Lys Thr Ser 685 gcggcgaacg agccggcgca gacccgggag ctgaggaacc ggatctttcc caccctctat 26231 gccatcttcc agcagagtcg ggggcaggag caggaactga aagtcaagaa ccgttctctg 26291 cgctcgctca cccgcagttg tctgtatcac aagagcgaag accaacttca gcgcactctc 26351 gaggacgccg aggctctctt caacaagtac tgcgcgctca ctcttaaaga gtagcccgcg 26411 cccgcccaca cacggaaaaa ggcgggaatt acgtcaccac ctgcgccctt cgcccgacca 26471 tcatgagcaa agagattccc acgccttaca tgtggagcta ccagccccag atgggcctgg 26531 ccgccggcgc cgcccaggac tactccaccc gcatgaactg gctcagtgcc gggcccgcga 26591 tgatctcacg ggtgaatgac atccgcgccc gccgaaacca gatactccta gaacagtcag 26651 cgatcgccgc cacgccccgc catcacctta atccgcgtaa ttggcccgcc gccctggtgt 26711 accaggaaat tccccagccc acgaccgtac tacttccgcg agacgcccag gccgaagtcc 26771 agctgactaa ctcaggtgtc cagctggccg gcggcgccgc cctgtgtcgt caccgccccg 26831 ctcagggtat aaagcggctg gtgatccgag gcagaggcac acagctcaac gacgaggtgg 26891 tgagctcttc gctgggtctg cgacctgacg gagtcttcca actcgccgga tcggggagat 26951 cttccttcac gcctcgtcag gccgtcctga ctttggagag ttcgtcctcg cagccccgct 27011 cgggcggcat cggcactctc cagttcgtgg aggagttcac tccctcggtc tacttcaacc 27071 ccttctccgg ctcccccggc cactacccgg acgagttcat cccgaacttc gacgccatca 27131 gcgagtcggt ggacggctac gattgaatgt cccatggtgg cgcagctgac ctagctcggc 27191 ttcgacacct ggaccactgc cgccgcttcc gctgcttcgc tcgggatctc gccgagtttg 27251 cctactttga gctgcccgag gagcaccctc agggcccagc ccacggagtg cggatcatcg 27311 tcgaaggggg cctcgactcc cacctgcttc ggatcttcag ccagcgaccg atcctggtcg 27371 agcgcgaaca aggacagacc cgtctgaccc tgtactgcat ctgcaaccac cccggcctgc 27431 atg aaa gtc ttt gtt gtc tgc tgt gta ctg agt ata ata aaa gct gag 27479 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 690 695 700 atc agc gac tac tcc gga ctc gat tgt ggt gtt cct gct atc aac cgg 27527 Ile Ser Asp Tyr Ser Gly Leu Asp Cys Gly Val Pro Ala Ile Asn Arg 705 710 715 tcc ctg ttc ttc acc ggg aac gaa acc gag ctc cag ctc cag tgt aag 27575 Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys 720 725 730 ccc cac aag aag tac ctc acc tgg ctg ttc cag ggc tcc ccc atc gcc 27623 Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala 735 740 745 gtt gtc aac cac tgc gac aac gac gga gtc ctg ctg agc ggc cct gcc 27671 Val Val Asn His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala 750 755 760 765 aac ctt act ttt tcc acc cgc aga agc aag ctc cag ctc ttc caa ccc 27719 Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro 770 775 780 ttc ctc ccc ggg acc tat cag tgc gtc tcg gga ccc tgc cat cac acc 27767 Phe Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro Cys His His Thr 785 790 795 ttc cac ctg atc ccg aat acc aca gcg ccg ctc ccc gct act aac aac 27815 Phe His Leu Ile Pro Asn Thr Thr Ala Pro Leu Pro Ala Thr Asn Asn 800 805 810 caa act aac ctc cac caa cgc cac cgt cgc gac ctt tcc tct gaa tct 27863 Gln Thr Asn Leu His Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser 815 820 825 aat acc act acc gga ggt gag ctc cga ggt cga cca acc tct ggg att 27911 Asn Thr Thr Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile 830 835 840 845 tac tac ggc ccc tgg gag gtg gtg ggg tta ata gcg cta ggc cta gtt 27959 Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val 850 855 860 gtg ggt ggg ctt ttg gct ctc tgc tac cta tac ctc cct tgc tgt tcg 28007 Val Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser 865 870 875 tac tta gtg gtg ctg tgt tgc tgg ttt aag aaa tgg ggc aga tca ccc 28055 Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 880 885 890 tagtgagctg cggtgtgctg gtggcggtgc tttcgattgt gggactgggc ggcgcggctg 28115 tagtgaagga ggagaaggcc gatccctgct tgcatttcaa tcccgacaaa tgccagctga 28175 gttttcagcc cgatggcaat cggtgcgcgg tgctgatcaa gtgcggatgg gaatgcgaga 28235 acgtgagaat cgagtacaat aacaagactc ggaacaatac tctcgcgtcc gtgtggcagc 28295 ccggggaccc cgagtggtac accgtctctg tccccggtgc tgacggctcc ccgcgcaccg 28355 tgaataatac tttcattttt gcgcacatgt gcaacacggt catgtggatg agcaagcagt 28415 acgatatgtg gccccccacg aaggagaaca tcgtggtctt ctccatcgct tacagcctgt 28475 gcacggcgct aatcaccgct atcgtgtgcc tgagcattca catgctcatc gctattcgcc 28535 ccagaaataa tgccgagaaa gagaaacagc cataacacgt tttttcacac accttgtttt 28595 tacagacaat gcgtctgtta aattttttaa acattgtgct cagtattgct tatgcctctg 28655 gttatgcaaa catacagaaa accctttatg taggatctga tggtacacta gagggtaccc 28715 aatcacaagc caaggttgca tggtattttt atagaaccaa cactgatcca gttaaacttt 28775 gtaagggtga attgccgcgt acacataaaa ctccacttac atttagttgc agcaataata 28835 atcttacact tttttcaatt acaaaacaat atactggtac ttattacagt acaaactttc 28895 atacaggaca agataaatat tatactgtta aggtagaaaa tcctaccact cctagaacta 28955 ccaccaccac caccactact gcaaagccca ctgtgaaaac tacaactagg accaccacaa 29015 ctacagaaac caccaccagc acaacacttg ctgcaactac acacacacac actaagctaa 29075 ccttacagac cactaatgat ttgatcgccc tgctgcaaaa gggggataac agcaccactt 29135 ccaatgagga gatacccaaa tccatgattg gcattattgt tgctgtagtg gtgtgcatgt 29195 tgatcatcgc cttgtgcatg gtgtactatg ccttctgcta cagaaagcac agactgaacg 29255 acaagctgga acacttacta agtgttgaat tttaattttt tagaaccatg aagatcctag 29315 gcctttttag tttttctatc attacctctg ctctttgtga atcagtggat agagatgtta 29375 ctattaccac tggttctaat tatacactga aagggccacc ctcaggtatg ctttcgtggt 29435 attgctattt tggaactgac actgatcaaa ctgaattatg caattttcaa aaaggcaaaa 29495 cctcaaactc taaaatctct aattatcaat gcaatggcac tgatctgata ctactcaatg 29555 tcacgaaagc atatggtggc agttattatt gccctggaca aaacactgaa gaaatgattt 29615 tttacaaagt ggaagtggtt gatcccacta caccacccac caccacaact attcatacca 29675 cacacacaga acaaacacca gaggcaacag aagcagagtt ggccttccag gttcacggag 29735 attcctttgc tgtcaatacc cctacacccg atcagcggtg tccggggccg ctagtcagcg 29795 gcattgtcgg tgtgctttcg ggattagcag tcataatcat ctgcatgttc atttttgctt 29855 gctgctatag aaggctttac cgacaaaaat cagacccact gctgaacctc tatgtttaat 29915 tttttccaga gccatgaagg cagttagcgc tctagttttt tgttctttga ttgacattgt 29975 ttttaatagt aaaattacca aagttagctt tattaaacat gttaatgtaa ctgaaggaga 30035 taacatcaca ctagcaggtg tagaaggtgc tcaaaacacc acctggacaa aataccatct 30095 aggatggaga gatatttgca cctggaatgt aacttattat tgcataggaa ttaatcttac 30155 cattgttaac gctaaccaat ctcagaatgg gttaattaaa ggacagagtg ttagtgtgac 30215 cagtgatggg tactataccc agcatagttt taactacaac attactgtca taccactgcc 30275 tacgcctagc ccacctagca ctaccacaca gacaaccaca tacagtacat caaatcagcc 30335 taccaccact acagcagcag aggttgccag ctcgtctggg gtccgagtgg catttttgat 30395 gttggcccca tctagcagtc ccactgctag taccaatgag cagactactg aatttttgtc 30455 cactgtcgag agccacacca cagctacctc cagtgccttc tctagcaccg ccaatctctc 30515 ctcgctttcc tctacaccaa tcagccccgc tactactcct agccccgctc ctcttcccac 30575 tcccctgaag caaacagacg gcggcatgca atggcagatc accctgctca ttgtgatcgg 30635 gttggtcatc ctggccgtgt tgctctacta catcttctgc cgccgcattc ccaacgcgca 30695 ccgcaagccg gcctacaagc ccatcgttat cgggcagccg gagccgcttc aggtggaagg 30755 gggtctaagg aatcttctct tctcttttac agtatggtga ttgaactatg attcctagac 30815 aattcttgat cactattctt atctgcctcc tccaagtctg tgccaccctc gctctggtgg 30875 ccaacgccag tccagactgt attgggccct tcgcctccta cgtgctcttt gccttcatca 30935 cctgcatctg ctgctgtagc atagtctgcc tgcttatcac cttcttccag ttcattgact 30995 ggatctttgt gcgcatcgcc tacctgcgcc accaccccca gtaccgcgac cagcgagtgg 31055 cgcagctgct caggctcctc tgataagcat gcgggctctg ctacttctcg cacttctgct 31115 gttagtgctc ccccgtcccg ttgacccccg gccccccact cagtcccccg aggaggtccg 31175 caaatgcaaa ttccaagaac cctggaaatt cctcaaatgc taccgccaaa aatcagacat 31235 gcatcccagc tggatcatga tcattgggat cgtgaacatt ctggcctgca ccctcatctc 31295 ctttgtgatt tacccctgct ttgactttgg ttggaactcg ccagaggcgc tctatctccc 31355 gcctgaacct gacacaccac cacagcaacc tcaggcacac gcactaccac caccaccaca 31415 gcctaggcca caatacatgc ccatattaga ctatgaggcc gagccacagc gacccatgct 31475 ccccgctatt agttacttca atctaaccgg cggag atg act gac cca ctg gcc 31528 Met Thr Asp Pro Leu Ala 895 aac aac aac gtc aac gac ctt ctc ctg gac atg gac ggc cgc gcc tcg 31576 Asn Asn Asn Val Asn Asp Leu Leu Leu Asp Met Asp Gly Arg Ala Ser 900 905 910 915 gag cag cga ctc gcc caa ctt cgc att cgc cag cag cag gag aga gcc 31624 Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg Gln Gln Gln Glu Arg Ala 920 925 930 gtc aag gag ctg cag gac ggc ata gcc atc cac cag tgc aag aaa ggc 31672 Val Lys Glu Leu Gln Asp Gly Ile Ala Ile His Gln Cys Lys Lys Gly 935 940 945 atc ttc tgc ctg gtg aaa cag gcc aag atc tcc tac gag gtc acc cag 31720 Ile Phe Cys Leu Val Lys Gln Ala Lys Ile Ser Tyr Glu Val Thr Gln 950 955 960 acc gac cat cgc ctc tcc tac gag ctc ctg cag cag cgc cag aag ttc 31768 Thr Asp His Arg Leu Ser Tyr Glu Leu Leu Gln Gln Arg Gln Lys Phe 965 970 975 acc tgc ctg gtc gga gtc aac ccc atc gtc atc acc cag cag tcg ggc 31816 Thr Cys Leu Val Gly Val Asn Pro Ile Val Ile Thr Gln Gln Ser Gly 980 985 990 995 gat acc aag ggg tgc atc cac tgc tcc tgc gac tcc ccc gac tgc 31861 Asp Thr Lys Gly Cys Ile His Cys Ser Cys Asp Ser Pro Asp Cys 1000 1005 1010 gtc cac act ctg atc aag acc ctc tgc ggc ctc cgc gac ctc ctc 31906 Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu Arg Asp Leu Leu 1015 1020 1025 ccc atg aac taatc 31920 Pro Met Asn <210> 71 <211> 503 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 71 Met Glu Ser Arg Asn Pro Phe Gln Gln Gly Leu Pro Ser Gly Leu Leu 1 5 10 15 Ser Ser Ser Phe Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn 20 25 30 Leu Arg Leu Leu Ala Ser Thr Ala Gly Arg His Ala Glu Asp Pro Glu 35 40 45 Ser Pro Val Thr Pro Gly Thr Pro Thr Pro Pro Ala Ala Ala Ala Gly 50 55 60 Ala Ala Ala Arg Gly Gly Gly Pro Arg Arg Glu Pro Glu Ser Arg Ser 65 70 75 80 Gly Pro Ser Gly Gly Gly Gly Gly Gly Val Ala Asp Leu Phe Pro Glu 85 90 95 Leu Arg Arg Val Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly Ile 100 105 110 Lys Arg Glu Arg His Glu Glu Thr Ser His Arg Thr Glu Leu Thr Val 115 120 125 Ser Leu Met Ser Arg Arg Arg Pro Glu Ser Val Trp Trp His Glu Val 130 135 140 Gln Ser Gln Gly Val Asp Glu Val Ser Val Met His Glu Lys Tyr Ser 145 150 155 160 Leu Glu Gln Val Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp Glu 165 170 175 Val Ala Ile Arg Asn Tyr Ala Lys Leu Ala Leu Arg Pro Asp Lys Lys 180 185 190 Tyr Lys Ile Thr Lys Leu Ile Asn Ile Arg Asn Ser Cys Tyr Ile Ser 195 200 205 Gly Asn Gly Ala Glu Val Glu Ile Ser Thr Gln Glu Arg Val Ala Phe 210 215 220 Arg Cys Cys Met Met Asn Met Tyr Pro Gly Val Val Gly Met Glu Gly 225 230 235 240 Val Thr Phe Met Asn Ala Arg Phe Arg Gly Asp Gly Tyr Asn Gly Val 245 250 255 Val Phe Met Ala Asn Thr Lys Leu Thr Val His Gly Cys Ser Phe Phe 260 265 270 Gly Phe Asn Asn Met Cys Ile Glu Ala Trp Gly Ser Val Ser Val Arg 275 280 285 Gly Cys Ser Phe Ser Ala Asn Trp Met Gly Val Val Gly Arg Thr Lys 290 295 300 Ser Lys Val Ser Val Lys Lys Cys Leu Phe Glu Arg Cys His Leu Gly 305 310 315 320 Val Met Ser Glu Gly Glu Ala Lys Val Lys His Cys Ala Ser Thr Glu 325 330 335 Thr Gly Cys Phe Val Cys Ile Lys Gly Asn Ala Gln Val Lys His Asn 340 345 350 Met Ile Cys Gly Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr Cys 355 360 365 Ala Gly Gly Asn Ser His Met Leu Ala Thr Val His Val Ala Ser His 370 375 380 Pro Arg Lys Thr Trp Pro Glu Phe Glu His Asn Val Met Thr Arg Cys 385 390 395 400 Asn Val His Leu Gly Ser Arg Arg Gly Met Phe Met Pro Tyr Gln Cys 405 410 415 Asn Met Gln Phe Val Lys Val Leu Leu Glu Pro Asp Ala Met Ser Arg 420 425 430 Val Ser Leu Ala Gly Val Phe Asp Met Asn Val Glu Leu Trp Lys Ile 435 440 445 Leu Arg Tyr Asp Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys Gly 450 455 460 Gly Lys His Ala Arg Leu Gln Pro Val Cys Val Glu Val Thr Glu Asp 465 470 475 480 Leu Arg Pro Asp His Leu Val Leu Ser Cys Asn Gly Thr Glu Phe Gly 485 490 495 Ser Ser Gly Glu Glu Ser Asp 500 <210> 72 <211> 182 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 72 Met Pro Arg Gly Asn Lys Lys Leu Lys Val Glu Leu Pro Pro Val Glu 1 5 10 15 Asp Leu Glu Glu Asp Trp Glu Asn Ser Ser Gln Ala Glu Glu Glu Glu 20 25 30 Met Glu Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln 35 40 45 Asp Ser Leu Glu Glu Asp Glu Glu Glu Ala Glu Val Glu Glu Ala Ala 50 55 60 Ala Ala Arg Pro Ser Ser Ser Ala Gly Glu Lys Ala Ser Ser Thr Asp 65 70 75 80 Thr Ile Ser Ala Pro Gly Arg Gly Pro Ala Arg Pro His Ser Arg Trp 85 90 95 Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys 100 105 110 Glu Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val 115 120 125 Ser Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr 130 135 140 Leu Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr 145 150 155 160 Tyr Arg His Leu His Ser Pro Tyr Tyr Phe Gln Glu Glu Ala Ala Glu 165 170 175 Lys Asp Gln Lys Thr Ser 180 <210> 73 <211> 208 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 73 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Asp Cys Gly Val Pro Ala Ile Asn Arg 20 25 30 Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys 35 40 45 Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala 50 55 60 Val Val Asn His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala 65 70 75 80 Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro 85 90 95 Phe Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro Cys His His Thr 100 105 110 Phe His Leu Ile Pro Asn Thr Thr Ala Pro Leu Pro Ala Thr Asn Asn 115 120 125 Gln Thr Asn Leu His Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser 130 135 140 Asn Thr Thr Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile 145 150 155 160 Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val 165 170 175 Val Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser 180 185 190 Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 195 200 205 <210> 74 <211> 135 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 74 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu Leu Leu Asp 1 5 10 15 Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg 20 25 30 Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Gly Ile Ala Ile 35 40 45 His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile 50 55 60 Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser Tyr Glu Leu Leu 65 70 75 80 Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val 85 90 95 Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys 100 105 110 Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu 115 120 125 Arg Asp Leu Leu Pro Met Asn 130 135 <210> 75 <211> 1440 <212> DNA <213> Unknown <220> <223> Simian adenovirus A1331 <220> <221> CDS <222> (576)..(1154) <223> E1a <220> <221> CDS <222> (1231)..(1434) <223> E1a <400> 75 cwwymtmwat aatatacctc aaacttttgg tgcgcgttaa tatgcaaatg agccgtttga 60 atttggggat ggaggaaggt gattggctgt gggagcggcg accgttaggg gcggggcggg 120 tgacgttttg atgacgtggc catgaggcgg agccggtttg caagttctcg tgggaaaagt 180 gacgtcaaac gaggtgtggt ttgaacacgg aaatactcaa ttttcccgcg ctctctgaca 240 ggaaatgagg tgtttctggg cggatgcaag tgaaaacggg ccattttcgc gcgaaaactg 300 aatgaggaag tgaaaatctg agtaattccg cgtttatggc agggaggagt atttgccgag 360 ggccgagtag actttgaccg attacgtggg ggtttcgatt accgtatttt tcacctaaat 420 ttccgcgtac ggtgtcaaag tccggtgttt ttacgtaggt gtcagctgat cgccagggta 480 tttaaacctg cgctctctag tcaagaggcc actcttgagt gccagcgagt agagttttct 540 cctccgcgcc gcgagtcaga tctacacttt gaaag atg agg cac ctg aga gac 593 Met Arg His Leu Arg Asp 1 5 ctg ccc ggt aat gtt ttc ctg gct act ggg aac gag att ctg gaa ctg 641 Leu Pro Gly Asn Val Phe Leu Ala Thr Gly Asn Glu Ile Leu Glu Leu 10 15 20 gtg gtg gac gcc atg atg ggt gac gac cct ccc gag ccc cct acc cca 689 Val Val Asp Ala Met Met Gly Asp Asp Pro Pro Glu Pro Pro Thr Pro 25 30 35 ttt gag gcg cct tcg ctg tac gat ttg tat gat ctg gag gtg gat gtg 737 Phe Glu Ala Pro Ser Leu Tyr Asp Leu Tyr Asp Leu Glu Val Asp Val 40 45 50 tcc gag aac gac ccc aac gag gag gcg gtg aat gat ttg ttt agc gat 785 Ser Glu Asn Asp Pro Asn Glu Glu Ala Val Asn Asp Leu Phe Ser Asp 55 60 65 70 gcc gcg ctg ctg gct gcc gag cag gct aat acg gac tct ggc tca gac 833 Ala Ala Leu Leu Ala Ala Glu Gln Ala Asn Thr Asp Ser Gly Ser Asp 75 80 85 agc gat tcc tct ctc cat acc ccg aga ccc ggc aga ggt gag aaa aag 881 Ser Asp Ser Ser Leu His Thr Pro Arg Pro Gly Arg Gly Glu Lys Lys 90 95 100 atc ccc gag ctt aaa ggg gaa gag ctc gac ctg cgc tgc tat gag gaa 929 Ile Pro Glu Leu Lys Gly Glu Glu Leu Asp Leu Arg Cys Tyr Glu Glu 105 110 115 tgc ttg cct ccg agc gat gat gag gag gac gag gag gcg att cga gct 977 Cys Leu Pro Pro Ser Asp Asp Glu Glu Asp Glu Glu Ala Ile Arg Ala 120 125 130 gca gcg agc gag gga gtg aaa gtt gcg ggc gag agc ttt agc ctg gac 1025 Ala Ala Ser Glu Gly Val Lys Val Ala Gly Glu Ser Phe Ser Leu Asp 135 140 145 150 tgt cct act ctg ccc gga cac ggc tgt aag tct tgt gaa ttt cat cgc 1073 Cys Pro Thr Leu Pro Gly His Gly Cys Lys Ser Cys Glu Phe His Arg 155 160 165 atg aat act gga gat aag aat gtg atg tgt gcc ctg tgc tat atg aga 1121 Met Asn Thr Gly Asp Lys Asn Val Met Cys Ala Leu Cys Tyr Met Arg 170 175 180 gct tac aac cat tgt gtt tac agt aag tgt gat taactttagt tgggaaaggc 1174 Ala Tyr Asn His Cys Val Tyr Ser Lys Cys Asp 185 190 agagggtgac tgggtgctga ctggtttatt tatgtatatg ttttttatgt gtaggt ccc 1233 Pro gtc tct gac gca gat gag acc ccc act tca gag tgc att tca tca ccc 1281 Val Ser Asp Ala Asp Glu Thr Pro Thr Ser Glu Cys Ile Ser Ser Pro 195 200 205 210 cca gaa att ggc gag gaa ccg ccc gaa gat att att cat aga cca gtt 1329 Pro Glu Ile Gly Glu Glu Pro Pro Glu Asp Ile Ile His Arg Pro Val 215 220 225 gca gtg aga gtc acc ggg cgg aga gca gct gtg gag agt ttg gat gac 1377 Ala Val Arg Val Thr Gly Arg Arg Ala Ala Val Glu Ser Leu Asp Asp 230 235 240 ttg cta cag ggt ggg gat gaa cct ttg gac ttg tgt acc cgg aaa cgc 1425 Leu Leu Gln Gly Gly Asp Glu Pro Leu Asp Leu Cys Thr Arg Lys Arg 245 250 255 ccc agg cac taagtg 1440 Pro Arg His 260 <210> 76 <211> 261 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 76 Met Arg His Leu Arg Asp Leu Pro Gly Asn Val Phe Leu Ala Thr Gly 1 5 10 15 Asn Glu Ile Leu Glu Leu Val Val Asp Ala Met Met Gly Asp Asp Pro 20 25 30 Pro Glu Pro Pro Thr Pro Phe Glu Ala Pro Ser Leu Tyr Asp Leu Tyr 35 40 45 Asp Leu Glu Val Asp Val Ser Glu Asn Asp Pro Asn Glu Glu Ala Val 50 55 60 Asn Asp Leu Phe Ser Asp Ala Ala Leu Leu Ala Ala Glu Gln Ala Asn 65 70 75 80 Thr Asp Ser Gly Ser Asp Ser Asp Ser Ser Leu His Thr Pro Arg Pro 85 90 95 Gly Arg Gly Glu Lys Lys Ile Pro Glu Leu Lys Gly Glu Glu Leu Asp 100 105 110 Leu Arg Cys Tyr Glu Glu Cys Leu Pro Pro Ser Asp Asp Glu Glu Asp 115 120 125 Glu Glu Ala Ile Arg Ala Ala Ala Ser Glu Gly Val Lys Val Ala Gly 130 135 140 Glu Ser Phe Ser Leu Asp Cys Pro Thr Leu Pro Gly His Gly Cys Lys 145 150 155 160 Ser Cys Glu Phe His Arg Met Asn Thr Gly Asp Lys Asn Val Met Cys 165 170 175 Ala Leu Cys Tyr Met Arg Ala Tyr Asn His Cys Val Tyr Ser Lys Cys 180 185 190 Asp Pro Val Ser Asp Ala Asp Glu Thr Pro Thr Ser Glu Cys Ile Ser 195 200 205 Ser Pro Pro Glu Ile Gly Glu Glu Pro Pro Glu Asp Ile Ile His Arg 210 215 220 Pro Val Ala Val Arg Val Thr Gly Arg Arg Ala Ala Val Glu Ser Leu 225 230 235 240 Asp Asp Leu Leu Gln Gly Gly Asp Glu Pro Leu Asp Leu Cys Thr Arg 245 250 255 Lys Arg Pro Arg His 260 <210> 77 <211> 36639 <212> DNA <213> Unknown <220> <223> Simian adenovirus A1337 <220> <221> repeat_region <222> (7)..(129) <223> ITR <220> <221> CDS <222> (1601)..(2164) <223> E1b\19K <220> <221> misc_feature <222> (3983)..(5604) <223> IVa2 complement (3983..5313,5593..5604) <220> <221> misc_feature <222> (5593)..(13844) <223> pol complement (5593..8658,13836..13844) <220> <221> misc_feature <222> (8466)..(13844) <223> pTP complement (8466..10394,13836..13844) <220> <221> CDS <222> (10831)..(12012) <223> 52K <220> <221> CDS <222> (12039)..(13805) <223> pIIIa <220> <221> CDS <222> (13889)..(15484) <223> penton <220> <221> CDS <222> (15491)..(16069) <223> pVII <220> <221> CDS <222> (16114)..(17139) <223> V <220> <221> CDS <222> (17166)..(17396) <223> pX <220> <221> CDS <222> (17431)..(18207) <223> pVI <220> <221> CDS <222> (18313)..(21105) <223> hexon <220> <221> CDS <222> (21121)..(21750) <223> protease <220> <221> misc_feature <222> (21830)..(23365) <223> DBP complement (21830...23365) <220> <221> CDS <222> (23394)..(25796) <223> 100K <220> <221> CDS <222> (26418)..(27098) <223> pVIII <220> <221> CDS <222> (27102)..(27419) <223> E3\12.5K <220> <221> CDS <222> (27996)..(28523) <223> E3\gp19K <220> <221> CDS <222> (28562)..(29302) <223> E3\CR1-beta <220> <221> CDS <222> (29318)..(29941) <223> E3\CR1-gamma <220> <221> CDS <222> (29964)..(30836) <223> E3\CR1-delta <220> <221> CDS <222> (31123)..(31569) <223> E3\RID=beta <220> <221> CDS <222> (32078)..(33547) <223> fiber <220> <221> misc_feature <222> (33643)..(34970) <223> E4\orf6/7 complement (33643..33893,34617..34970) <220> <221> misc_feature <222> (33894)..(34790) <223> E4\orf6 complement (33894..34790) <220> <221> misc_feature <222> (34696)..(35061) <223> E4\orf4 complement (34696..35061) <220> <221> misc_feature <222> (35073)..(35423) <223> E4\orf3 complement (35073..35423) <220> <221> misc_feature <222> (35423)..(35809) <223> E4\orf2 complement (35423..35809) <220> <221> misc_feature <222> (35862)..(36233) <223> E4\orf1 complement (35862..36233) <220> <221> repeat_region <222> (36511)..(36633) <223> ITR complement (36400..36528) <400> 77 catcatcaat aatatacctc aaactttttg tgcgcgttaa tatgcaaatg aggcgtttga 60 atttgggaag ggaggaaggt gattggccga gagaagggcg accgttaggg gcggggcgag 120 tgacgttttg atgacgtggc cgcgaggagg agccagtttg caagttctcg tgggaaaagt 180 gacgtcaaac gaggtgtggt ttgaacacgg aaatactcaa ttttcccgcg ctctctgaca 240 ggaaatgagg tgtttttggg cggatgcaag ttaaaacggg ccattttcgc gcgaaaactg 300 aatgaggaag tgaaaatctg agtaatttcg cgtttatggc agggaggagt atttgccgag 360 ggccgagtag actttgaccg attacgtggg ggtttcgatt accgtgtttt tcacctaaat 420 ttccgcgtac ggtgtcaaag tccggtgttt ttacgtaggt gtcagctgat cgccagggta 480 tttaaacctg cgctctccag tcaagaggcc actcttgagt gccagcgaga agagttttct 540 cctccgcgcc gcgagtcaga tctacacttt gaaagatgag gcacctgaga gacctgcccg 600 atgagaaaat catcatcgct tccgggaacg agattctgga actggtggta aatgccatga 660 tgggcgacga ccctccggag ccccccaccc catttgaggt accttcgcta cacgatttgt 720 atgatctgga ggtggatgtg cccgaggacg accccaacga ggaggcggta aatgatttat 780 ttagcgatgc cgcgctgcta gctgccgagg aggcttcgag ccctagctca gacagcgact 840 cttcactgca tacccctaga cccggcagag gtgagaaaaa gatccccgag cttaaagggg 900 aagagatgga cttgcgctgc tatgaggaat gcttgccccc gagcgatgat gaggacgagc 960 aggcgatcca gaacgcagcg agccagggag tgcaagccgc cagcgagagc tttgcgctgg 1020 actgcccgcc tctgcccgga cacggctgta agtcttgtga atttcatcgc atgaatactg 1080 gagataaagc tgtgttatgt gcactttgct atatgagagc ttacaaccat tgtgtttaca 1140 gtaagtgtga ttaagttgaa ctttagaggg aggcagagag cagggtgact gggcgatgac 1200 tggtttattt atgtatatat gttctttata taggtcccgt ctctgacgca gatgatgaga 1260 cccccactac agagtccact tcgtcacccc cagaaattgg cacatctcca cctgagaata 1320 ttgttagacc agttcctgtt agagccactg ggaggagagc agctgtggaa tgtttggatg 1380 acttgctaca gggtggggat gaacctttgg acttgtgtac ccggaaacgc cccaggcact 1440 aagtgccaca catgtgtgtt tacttgaggt gatgtcagta tttatagggt gtggagtgca 1500 ataaaaaatg tgttgacttt aagtgcgtgg tttatgactc aggggtgggg actgtgggta 1560 tataagcagg tgcagacctg tgtggttagc tcagagcggc atg gag att tgg acg 1615 Met Glu Ile Trp Thr 1 5 gtc ttg gaa gac ttt cac aag act aga cag ctg cta gag aac gcc tcg 1663 Val Leu Glu Asp Phe His Lys Thr Arg Gln Leu Leu Glu Asn Ala Ser 10 15 20 aac gga gtc tct tac ctg tgg aga ttc tgc ttc ggt ggc gac cta gct 1711 Asn Gly Val Ser Tyr Leu Trp Arg Phe Cys Phe Gly Gly Asp Leu Ala 25 30 35 agg cta gtc tac agg gcc aaa cag gat tat agt gaa caa ttt gag gtt 1759 Arg Leu Val Tyr Arg Ala Lys Gln Asp Tyr Ser Glu Gln Phe Glu Val 40 45 50 att ttg aga gag tgt cct ggt ctt ttt gac gct ctt aac ttg ggc cat 1807 Ile Leu Arg Glu Cys Pro Gly Leu Phe Asp Ala Leu Asn Leu Gly His 55 60 65 cag tct cac ttt aac cag agg att tcg aga gcc ctt gac ttt act act 1855 Gln Ser His Phe Asn Gln Arg Ile Ser Arg Ala Leu Asp Phe Thr Thr 70 75 80 85 cct ggc aga acc act gca gca gta gcc ttt ttt gct ttt att ctt gac 1903 Pro Gly Arg Thr Thr Ala Ala Val Ala Phe Phe Ala Phe Ile Leu Asp 90 95 100 aaa tgg agt caa gaa acc cat ttc agc agg gat tac cag ctg gat ttc 1951 Lys Trp Ser Gln Glu Thr His Phe Ser Arg Asp Tyr Gln Leu Asp Phe 105 110 115 tta gca gta gct ttg tgg aga aca tgg aag tgc cag cgc ctg aat gca 1999 Leu Ala Val Ala Leu Trp Arg Thr Trp Lys Cys Gln Arg Leu Asn Ala 120 125 130 atc tcc ggc tac ttg ccg gta cag ccg cta gac act ctg agg atc ctg 2047 Ile Ser Gly Tyr Leu Pro Val Gln Pro Leu Asp Thr Leu Arg Ile Leu 135 140 145 aat ctc cag gag agt ccc agg gca cgc caa cgt cgc cag cag cag cag 2095 Asn Leu Gln Glu Ser Pro Arg Ala Arg Gln Arg Arg Gln Gln Gln Gln 150 155 160 165 cgg cag cag gag gag gat caa gaa gag aac ccg aga gcc ggc ctg gac 2143 Arg Gln Gln Glu Glu Asp Gln Glu Glu Asn Pro Arg Ala Gly Leu Asp 170 175 180 cct ccg gag gag gag gag gag tagctgacct gtttcctgaa ctgcgccggg 2194 Pro Pro Glu Glu Glu Glu Glu 185 tgctgactag gtcttcgagt ggtcgggaga gggggattaa gcgggagagg catgatgaga 2254 ctaatcacag aactgaactg actgtcagtc tgatgagccg caagcgccca gaaacagtgt 2314 ggtggcatga ggtgcagtcg actggcacag atgaggtgtc agtgatgcat gagaagtttt 2374 ctctagaaca agtcaagact tgttggttag agcctgagga tgattgggaa gtagccatca 2434 ggaattatgc caagctggct ctgatgccag acaagaagta caagattact aagctgataa 2494 atatcagaaa tgcctgctac atctcaggga atggggctga agtggagatt tgtctccagg 2554 atagagtggc tttcagatgc tgcatgatga atatgtaccc gggagtggtg ggcatggatg 2614 gggtcacctt tatgaacatg aggttcaggg gagatgggta taatggtacg gtctttatgg 2674 ccaataccaa gctgacagtc catggctgct ccttctttgg gtttaataac acttgcattg 2734 aggcctgggg ccaggtaggc gtgaggggct gcagtttttc agccaactgg atgggggtcg 2794 tgggcaggac caagagtatg ctgtccgtga agaaatgctt gtttgagagg tgccacctgg 2854 gggtgatgag cgagggcgaa gccagaatcc gccactgcgc ctctaccgag acgggctgct 2914 tcgtgctgtg caagggcaat gccaagatca agcataatat gatctgtgga gcctcggacg 2974 agcgcggcta ccagatgctg acctgtgccg gtgggaacag ccatatgctg gccaccgtgc 3034 atgtggcttc ccatgcccgc aagccctggc ccgagttcga gcacaatgtc atgaccaggt 3094 gcaatatgca tctggggtct cgccgaggca tgttcatgcc ctaccagtgc aacctgaatt 3154 atgtgaaggt gctgctggag cccgatgcca tgtccagagt gagcctgacg ggggtgtttg 3214 acatgaatgt ggaggtgtgg aagattctga gatatgatga atccaagacc aggtgccgag 3274 cctgcgagtg cggagggaag catgccaggt tccagcccgt gtgtgtggat gtgacggagg 3334 acctgcgacc cgatcatttg gtgttgtcct gcaccgggac ggagttcggt tccagcgggg 3394 aagaatctga ctagagtgag tagtgttctg gggcggggga ggacctgcat gagggccaga 3454 atgattgaaa tctgtgcttt tctgtgtgtt gcagcagcat gagcggaagc ggctcctttg 3514 agggaggggt attcagccct tatctgacgg ggcgtctccc ctcctgggcg ggagtgcgtc 3574 agaatgtgat gggatccacg gtggacggcc ggcccgtgca gcccgcgaac tcttcaaccc 3634 tgacctatgc aaccctgagc tcttcgtcgg tggacgcagc tgccgccgca gctgctgcat 3694 ctgccgccag cgccgtgcgc ggaatggcca tgggcgccgg ctactacggc actctggtgg 3754 ccaactcgag ttccaccaat aatcccgcca gcctgaacga ggagaagctg ctgctgctga 3814 tggcccagct cgaggccttg acccagcgcc tgggcgagct gacccagcag gtggctcagc 3874 tgcaggagca gacgcgggcc gcggttgcca cggtgaaatc caaataaaaa atgaatcaat 3934 aaataaacgg agacggttgt tgattttaac acagagtctg aatctttatt tgatttttcg 3994 cgcgcggtag gccctggacc accggtctcg atcattgagc actcggtgga tcttttccag 4054 gacccggtag aggtgggctt ggatgttgag gtacatgggc atgagcccgt cccgggggtg 4114 gaggtagctc cattgcaggg cctcgtgctc gggggtggtg ttgtaaatca cccagtcata 4174 gcaggggcgc agggcatggt gttgcacaat atctttgagg aggagactga tggccacggg 4234 cagccctttg gtgtaggtgt ttacaaatct gttgagctgg gagggatgca tgcgggggga 4294 gatgaggtgc atcttggcct ggatcttgag attggcgatg ttaccgccca gatcccgcct 4354 ggggttcatg ttgtgcagga ccaccagcac ggtgtatccg gtgcacttgg ggaatttatc 4414 atgcaacttg gaagggaagg cgtgaaagaa tttggcgacg cccttgtgcc cgcccaggtt 4474 ttccatgcac tcatccatga tgatggcgat ggggccgtgg gcggcggcct gggcaaaaac 4534 gtttcggggg tcggacacat catagttgtg gtcctgggtg agatcatcat aggccatttt 4594 aatgaatttg gggcggaggg tgccggactg ggggacaaag gtaccctcga tcccgggggc 4654 gtagttcccc tcacagatct gcatctccca ggctttgagc tcggaggggg ggatcatgtc 4714 cacctgcggg gcgataaaga acacggtttc cggggcggga gagatgagct gggccgaaag 4774 caagttccgg agcagctggg acttgccgca gccggtgggg ccgtagatga ccccgatgac 4834 cggttgcagg tggtagttga gggagagaca gctgccgtcc tcccggagga ggggggccac 4894 ctcgttcatc atctcgcgca cgtgcatgtt ctcgcgcacc agttccgcca ggaggcgctc 4954 tccccccagg gataggagct cctggagcga ggcgaagttt ttcagcggct tgagtccgtc 5014 ggccatgggc attttggaga gggtctgttg caagagttcc aagcggtccc agagctcggt 5074 gatgtgctct acggcatctc gatccagcag acctcctcgt ttcgcgggtt ggggcggctg 5134 cgggagtagg gcaccagacg atgggcgtcc agcgcagcca gggtccggtc cttccagggt 5194 cgcagcgtcc gcgtcagggt ggtctccgtc acggtgaagg ggtgcgcgcc gggctgggcg 5254 cttgcgaggg tgcgcttcag gctcatccgg ctggtcgaaa accgctcccg atcggcgccc 5314 tgcgcgtcgg ccaggtagca attgaccatg agttcgtaat tgagcgcctc ggccgcgtga 5374 cctttggcgc ggagcttacc tttggaagtc tgcccgcagg tgggacagag gagggacttg 5434 agggcgtaga gcttgggggc gaggaagacg gactcggggg cgtaggcgtc cgcgccgcag 5494 tgggcgcaga cggtctcgca ctccacgagc caggtgaggt cgggctggtc ggggtcaaaa 5554 accagtttcc cgccgttctt tttgatgcgt ttcttacctt tggtctccat gagctcgtgt 5614 ccccgctggg tgacaaagag gctgtccgtg tccccgtaga ccgactttat gggccggtcc 5674 tcgagcggtg tgccgcggtc ctcctcgtag aggaaccccg cccactccga gacgaaagcc 5734 cgggtccagg ccagcacgaa ggaggccacg tgggacgggt agcggtcgtt gtccaccagc 5794 gggtccacct tctccagggt atgcaaacac atgtccccct cgtccacatc caggaaggtg 5854 attggcttgt aagtgtaggc cacgtgaccg ggggtcccag ccgggggggt ataaaagggg 5914 gcgggcccct gctcgtcctc actgtcttcc ggatcgctgt ccaggagcgc cagctgttgg 5974 ggtaggtatt ccctctcgaa ggcgggcatg acctcggcac tcaggttgtc agtttctaga 6034 aacgaggagg atttgatatt gacggtgccg gcggagatgc ctttcaagag cccctcgtcc 6094 atctggtcag aaaagacgat ctttttgttg tcgagtttgg tggcgaagga gccgtagagg 6154 gcattggaga ggagcttggc gatagagcgc atggtctggt ttttttcctt gtcggcgcgc 6214 tccttggccg cgatgttgag ctgcacgtac tcgcgcgcca cgcacttcca ttcggggaag 6274 acggtggtca gctcgtcggg cacgattctg acttgccagc cccggttatg cagggtgatg 6334 aggtccacac tggtgcccac ctcgccgcgc aggggctcgt tggtccagca gagtcgaccg 6394 cccttgcgcg agcagaaggg gggcaggggg tccagcatga cctcgtcggg ggggtcggca 6454 tcgatggtga agatgcctgg caggagatcg gggtcgaagt agctgatgga agtggccaga 6514 tcgtccaggg cagcttgcca ttcgcgcacg gccagcgcgc gctcgtaggg actgaggggc 6574 gtgccccaag gcatggggtg tgtgagcgcg gaggcgtaca tgccgcagat gtcgtagacg 6634 tagaggggct cctcgaggat gccgatgtag gtggggtaac agcgcccccc gcggatgctg 6694 gcgcgcacgt agtcatacag ctcatgcgag ggggcgagga gccccgggcc caggttggtg 6754 cgactgggct tttcggcgcg gtagacgatc tggcgaaaga tggcatgcga gttggaggag 6814 atggtgggcc tttggaagat gttgaagtgg gcgtggggca gaccgaccga gtcgcggatg 6874 aagtgggcgt aggagtcttg cagtttggcg acgagctcgg cggtgacgag gacgtccaga 6934 gcgcagtagt cgagggtctc ctggatgatg tcatacttga gctggccctt ttgtttccac 6994 agctcgcggt tgagaaggaa ctcttcgcgg tccttccagt actcttcgag ggggaacccg 7054 tcctgatctg cacggtaaga gcctagcatg tagaactggt tgacggcctt gtaggcgcag 7114 cagcccttct ccacggggag ggcgtaggcc tgggcggcct tgcgcaggga ggtgtgcgtg 7174 agggcgaagg tgtccctgac catgaccttg aggaactggt gcttgaaatc gatatcgtcg 7234 cagcccccct gctcccagag ctggaagtcc gtgcgcttct tgtaggcggg gttgggcaaa 7294 gcgaaagtaa catcgttgaa aaggatcttg cccgcgcggg gcataaagtt gcgagtgatg 7354 cggaaaggct ggggcacctc ggcccggttg ttgatgacct gggcggcgag cacgatctcg 7414 tcgaaaccgt tgatgttgtg gcccacgatg tagagttcca cgaatcgcgg gcggcccttg 7474 acgtggggca gcttcttgag ctcctcgtag gtgagctcgt cggggtcgct gagaccgtgc 7534 tgctcgagcg cccagtcggc gagatggggg ttggcgcgga ggaaggaagt ccagagatcc 7594 acggccaggg cggtttgcag acggtcccgg tactgacgga actgctgccc gacggccatt 7654 ttttcggggg tgacgcagta gaaggtgcgg gggtccccgt gccagcggtc ccatttgagc 7714 tggagggcga gatcgagggc gagctcgacg aggcggtcgt ccccggagag tttcatgacc 7774 agcatgaagg ggacgagctg cttgccgaag gaccccatcc aggtgtaggt ttccacatcg 7834 taggtgagga agagcctttc ggtgcgagga tgcgagccga tggggaagaa ctggatctcc 7894 tgccaccaat tggaggaatg gctgttgatg tgatggaagt agaaatgccg acggcgcgcc 7954 gaacactcgt gcttgtgttt atacaagcgg ccacagtgct cgcaacgctg cacgggatgc 8014 acgtgctgca cgagctgtac ctgagttcct ttgacgagga atttcagtgg gaagtggagt 8074 cgtggcgcct gcatctcgtg ctgtactacg tcgtggtggt cggcctggcc ctcttctgcc 8134 tcgatggtgg tcatgctgac gagcccgcgc gggaggcagg tccagacctc ggcgcgagcg 8194 ggtcggagag cgaggacgag ggcgcgcagg ccggagctgt ccagggtcct gagacgctgc 8254 ggagtcaggt cagtgggcag cggcggcgcg cggttgactt gcaggagttt ttccagggcg 8314 cgcgggaggt ccagatggta cttgatctcc accgcgccgt tggtggcgac gtcgatggct 8374 tgcagggtcc cgtgcccctg gggtgtgacc accgtccccc gtttcttctt gggcggctgg 8434 ggcgacgggg gcggtgcctc ttccatggtt agaagcggcg gcgaggacgc gcgccgggcg 8494 gcagaggcgg ctcggggccc ggaggcaggg gcggcagggg cacgtcggcg ccgcgcgcgg 8554 gtaggttctg gtactgcgcc cggagaagac tggcgtgagc gacgacgcga cggttgacgt 8614 cctggatctg acgcctctgg gtgaaggcca cgggacccgt gagtttgaac ctgaaagaga 8674 gttcgacaga atcaatctcg gtatcgttga cggcggcctg ccgcaggatc tcttgcacgt 8734 cgcccgagtt gtcctggtag gcgatctcgg tcatgaactg ctcgatctcc tcctcctgaa 8794 ggtctccgcg gccggcgcgc tccacggtgg ccgcgaggtc gttggagatg cggcccatga 8854 gctgcgagaa ggcgttcatg cccgcctcgt tccagacgcg gctgtagacc acgacgccct 8914 cgggatcgcg ggcgcgcatg accacctggg cgaggttgag ctccacgtgg cgcgtgaaga 8974 ccgcgtagtt gcagaggcgc tggtagaggt agttgagcgt ggtggcgatg tgctcggtga 9034 cgaagaaata catgatccag cggcggagcg gcatctcgct gacgtcgccc agcgcctcca 9094 agcgttccat ggcctcgtaa aagtccacgg cgaagttgaa aaactgggag ttgcgcgccg 9154 agacggtcaa ctcctcctcc agaagacgga tgagctcggc gatggtggcg cgcacctcgc 9214 gctcgaaggc ccccgggagt tcctcctctt ccatctcctc ttcttcctcc tccactaaca 9274 tctcttctac ttcctcctca ggcggtggtg gcgggggagg gggcctgcgt cgccggcggc 9334 gcacgggcag acggtcgatg aagcgctcga tggtctcgcc gcgccggcgt cgcatggtct 9394 cggtgacggc gcgcccgtcc tcgcggggcc gcagcgtgaa gacgccgccg cgcatctcca 9454 ggtggccggg ggggtccccg ttgggcaggg agagggcgct gacgatgcat cttatcaatt 9514 gccccgtagg gactccgcgc aaggacctga gcgtctcgag atccacggga tctgaaaacc 9574 gttgaacgaa ggcttcgagc cagtcgcagt cgcaaggtag gctgagcacg gtttcttctg 9634 gcgggtcatg ttggggagcg gggcgggcga tgctgctggt gatgaagttg aaataggcgg 9694 ttctgagacg gcggatggtg gcgaggagca ccaggtcttt gggcccggct tgctggatgc 9754 gcagacggtc ggccatgccc caggcgtggt cctgacacct ggccaggtcc ttgtagtagt 9814 cctgcatgag ccgctccacg ggcacctcct cctcgcccgc gcggccgtgc atgcgcgtga 9874 gcccgaagcc gcgctggggc tggacgagcg ccaggtcggc gacgacgcgc tcggcgagga 9934 tggcctgctg gatctgggtg agggtggtct ggaagtcgtc aaagtcgacg aagcggtggt 9994 aggctccggt gttgatggtg taggagcagt tggccatgac ggaccagttg acggtctggt 10054 ggcccggacg cacgagctcg tggtacttga ggcgcgagta ggcgcgcgtg tcgaagatgt 10114 agtcgttgca ggtgcgcacc aggtactggt agccgatgag gaagtgcggc ggcggctggc 10174 ggtagagcgg ccatcgctcg gtggcggggg cgccgggcgc gaggtcctcg agcatggtgc 10234 ggtggtagcc gtagatgtac ctggacatcc aggtgatgcc ggcggcggtg gtggaggcgc 10294 gcgggaactc gcggacgcgg ttccagatgt tgcgcagcgg caggaagtag ttcatggtgg 10354 gcacggtctg gcccgtgagg cgcgcgcagt cgtggatgct ctatacgggc aaaaacgaaa 10414 gcggtcagcg gctcgactcc gtggcctgga ggctaagcga acgggttggg ctgcgcgtgt 10474 accccggttc gaatctcgaa tcaggctgga gccgcagcta acgtggtact ggcactcccg 10534 tctcgaccca agcctgcacc aaccctccag gatacggagg cgggtcgttt tgcaactttt 10594 tttcggaggc cggaaatgaa gactagtaag cgcggaaagc ggccgaccgc gatggctcgc 10654 tgccgtagtc tggagaagaa tcgccagggt tgcgttgcgg tgtgccccgg ttcgaggccg 10714 gccggattcc gcggctaacg agggcgtggc tgccccgtcg tttccaagac cccctagcca 10774 gccgacttct ccagttacgg agcgagcccc tcttttgttt tgtttgtttt tgccag atg 10833 Met cat ccc gta ctg cgg cag atg cgc ccc cac cac cct cca ccg caa caa 10881 His Pro Val Leu Arg Gln Met Arg Pro His His Pro Pro Pro Gln Gln 190 195 200 205 cag ccc cct cca cag ccg gcg ctt ctg ccc ccg ccc cag cag cag cag 10929 Gln Pro Pro Pro Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln Gln 210 215 220 caa ctt cca gcc acg acc gcc gcg gcc gcc gtg agc ggg gct gga cag 10977 Gln Leu Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala Gly Gln 225 230 235 act tct cag tat gac ctg gcc ttg gaa gag ggc gag ggg ctg gcg cgc 11025 Thr Ser Gln Tyr Asp Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala Arg 240 245 250 ctg ggg gcg tcg tcg ccg gag cgg cac ccg cgc gtg cag atg aaa agg 11073 Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys Arg 255 260 265 gac gct cgc gag gcc tac gtg ccc aag cag aac ctg ttc aga gac agg 11121 Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp Arg 270 275 280 285 agc ggc gag gag ccc gag gag atg cgc gcg gcc cgg ttc cac gcg ggg 11169 Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ala Arg Phe His Ala Gly 290 295 300 cgg gag ctg cgg cgc ggc ctg gac cga aag agg gtg ctg agg gac gag 11217 Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp Glu 305 310 315 gat ttc gag gcg gac gag ctg acg ggg atc agc ccc gcg cgc gcg cac 11265 Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala His 320 325 330 gtg gcc gcg gcc aac ctg gtc acg gcg tac gag cag acc gtg aag gag 11313 Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys Glu 335 340 345 gag agc aac ttc caa aaa tcc ttc aac aac cac gtg cgc acc ctg atc 11361 Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu Ile 350 355 360 365 gcg cgc gag gag gtg acc ctg ggc ctg atg cac ctg tgg gac ctg ctg 11409 Ala Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu Leu 370 375 380 gag gcc atc gtg cag aac ccc acc agc aag ccg ctg acg gcg cag ctg 11457 Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln Leu 385 390 395 ttc ctg gtg gtg cag cat agt cgg gac aac gag gcg ttc agg gag gcg 11505 Phe Leu Val Val Gln His Ser Arg Asp Asn Glu Ala Phe Arg Glu Ala 400 405 410 ctg ctg aat atc acc gag ccc gag ggc cgc tgg ctc ctg gac ctg gtg 11553 Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu Val 415 420 425 aac att ctg cag agc atc gtg gtg cag gag cgc ggg ctg ccg ctg tcc 11601 Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu Ser 430 435 440 445 gag aag ctg gcg gcc atc aac ttc tcg gtg ctg agt ctg ggc aag tac 11649 Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys Tyr 450 455 460 tac gct agg aag atc tac aag acc ccg tac gtg ccc ata gac aag gag 11697 Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys Glu 465 470 475 gtg aag atc gac ggg ttt tac atg cgc atg acc ctg aaa gtg ctg acc 11745 Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu Thr 480 485 490 ctg agc gac gat ctg ggg gtg tac cgc aac gac agg atg cac cgc gcg 11793 Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg Ala 495 500 505 gtg agc gcc agc agg cgg cgc gag ctg agc gac cag gag ctg atg cat 11841 Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met His 510 515 520 525 agt ctg cag cgg gcc ctg acc ggg gcc ggg acc gag ggg gag agc tac 11889 Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser Tyr 530 535 540 ttt gac atg ggc gcg gac ctg cac tgg cag ccc agc cgc cgg gcc ttg 11937 Phe Asp Met Gly Ala Asp Leu His Trp Gln Pro Ser Arg Arg Ala Leu 545 550 555 gag gcg gca ggc ggt ccc ccc tac ata gaa gag gtg gac gat gag gtg 11985 Glu Ala Ala Gly Gly Pro Pro Tyr Ile Glu Glu Val Asp Asp Glu Val 560 565 570 gac gag gag ggc gag tac ctg gaa gac tgatggcgcg accgtatttt tgctag 12038 Asp Glu Glu Gly Glu Tyr Leu Glu Asp 575 580 atg caa caa cag cca cct cct gat ccc gcg atg cgg gcg gcg ctg cag 12086 Met Gln Gln Gln Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu Gln 585 590 595 agc cag ccg tcc ggc att aac tcc tcg gac gat tgg acc cag gcc atg 12134 Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala Met 600 605 610 caa cgc atc atg gcg ctg acg acc cgc aac ccc gaa gcc ttt aga cag 12182 Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg Gln 615 620 625 630 cag ccc cag gcc aac cgg ctc tcg gcc atc ctg gag gcc gtg gtg ccc 12230 Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val Pro 635 640 645 tcg cgc tcc aac ccc acg cac gag aag gtc ctg gcc atc gtg aac gcg 12278 Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn Ala 650 655 660 ctg gtg gag aac aag gcc atc cgc ggc gac gag gcc ggc ctg gtg tac 12326 Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val Tyr 665 670 675 aac gcg ctg ctg gag cgc gtg gcc cgc tac aac agc acc aac gtg cag 12374 Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val Gln 680 685 690 acc aac ctg gac cgc atg gtg acc gac gtg cgc gag gcc gtg gcc cag 12422 Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ala Gln 695 700 705 710 cgc gag cgg ttc cac cgc gag tcc aac ctg gga tcc atg gtg gcg ctg 12470 Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala Leu 715 720 725 aac gcc ttc ctc agc acc cag ccc gcc aac gtg ccc cgg ggc cag gag 12518 Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln Glu 730 735 740 gac tac acc aac ttc atc agc gcc ctg cgc ctg atg gtg acc gag gtg 12566 Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Thr Glu Val 745 750 755 ccc cag agc gag gtg tac cag tcc ggg ccg gac tac ttc ttc cag acc 12614 Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr 760 765 770 agt cgc cag ggc ttg cag acc gtg aac ctg agc cag gcg ttc aag aac 12662 Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys Asn 775 780 785 790 ttg cag ggc ctg tgg ggc gtg cag gcc ccg gtc ggg gac cgc gcg acg 12710 Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala Thr 795 800 805 gtg tcg agc ctg ctg acg ccg aac tcg cgc ctg ctg ctg ctg ctg gtg 12758 Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu Val 810 815 820 gcc ccc ttc acg gac agc ggc agc atc aac cgc aac tcg tac ctg ggc 12806 Ala Pro Phe Thr Asp Ser Gly Ser Ile Asn Arg Asn Ser Tyr Leu Gly 825 830 835 tac ctg att aac ctg tac cgc gag gcc atc ggc cag gcg cac gtg gac 12854 Tyr Leu Ile Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp 840 845 850 gag cag acc tac cag gag atc acc cac gtg agc cgc gcc ctg ggc cag 12902 Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly Gln 855 860 865 870 gac gac ccg ggc aat ctg gaa gcc acc ctg aac ttt ttg ctg acc aac 12950 Asp Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr Asn 875 880 885 cgg tcg cag aag atc ccg ccc cag tac acg ctc agc gcc gag gag gag 12998 Arg Ser Gln Lys Ile Pro Pro Gln Tyr Thr Leu Ser Ala Glu Glu Glu 890 895 900 cgc atc ctg cga tac gtg cag cag agc gtg ggc ctg ttc ctg atg cag 13046 Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met Gln 905 910 915 gag ggg gcc acc ccc agc gcc gcg ctc gac atg acc gcg cgc aac atg 13094 Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn Met 920 925 930 gag ccc agc atg tac gcc agc aac cgc ccg ttc atc aat aaa ctg atg 13142 Glu Pro Ser Met Tyr Ala Ser Asn Arg Pro Phe Ile Asn Lys Leu Met 935 940 945 950 gac tac ttg cat cgg gcg gcc gcc atg aac tct gac tat ttc acc aac 13190 Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr Asn 955 960 965 gcc atc ctg aat ccc cac tgg ctc ccg ccg ccg ggg ttc tac acg ggc 13238 Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr Gly 970 975 980 gag tac gac atg ccc gac ccc aat gac ggg ttc ctg tgg gac gat gtg 13286 Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp Val 985 990 995 gac agc agc gtg ttc tcc ccc cga ccg ggt gct aac gag cgc ccc 13331 Asp Ser Ser Val Phe Ser Pro Arg Pro Gly Ala Asn Glu Arg Pro 1000 1005 1010 ttg tgg aag aag gaa ggc agc gac cga cgc ccg tcc tcg gcg ctg 13376 Leu Trp Lys Lys Glu Gly Ser Asp Arg Arg Pro Ser Ser Ala Leu 1015 1020 1025 tcc ggc cgc gag ggt gct gcc gcg gcg gtg ccc gag gcc gcc agt 13421 Ser Gly Arg Glu Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser 1030 1035 1040 cct ttc ccg agc ttg ccc ttc tcg ctg aac agt att cgc agc agc 13466 Pro Phe Pro Ser Leu Pro Phe Ser Leu Asn Ser Ile Arg Ser Ser 1045 1050 1055 gag ctg ggc agg atc acg cgc ccg cgc ttg ctg ggc gag gag gag 13511 Glu Leu Gly Arg Ile Thr Arg Pro Arg Leu Leu Gly Glu Glu Glu 1060 1065 1070 tac ttg aat gac tcg ctg ttg aga ccc gag cgg gag aag aac ttc 13556 Tyr Leu Asn Asp Ser Leu Leu Arg Pro Glu Arg Glu Lys Asn Phe 1075 1080 1085 ccc aat aac ggg ata gag agc ctg gtg gac aag atg agc cgc tgg 13601 Pro Asn Asn Gly Ile Glu Ser Leu Val Asp Lys Met Ser Arg Trp 1090 1095 1100 aag acg tat gcg cag gag cac agg gac gat ccg tcg cag ggg gcc 13646 Lys Thr Tyr Ala Gln Glu His Arg Asp Asp Pro Ser Gln Gly Ala 1105 1110 1115 acg agc cgg ggc agc gcc gcc cgt aaa cgc cgg tgg cac gac agg 13691 Thr Ser Arg Gly Ser Ala Ala Arg Lys Arg Arg Trp His Asp Arg 1120 1125 1130 cag cgg gga ctg atg tgg gac gat gag gat tcc gcc gac gac agc 13736 Gln Arg Gly Leu Met Trp Asp Asp Glu Asp Ser Ala Asp Asp Ser 1135 1140 1145 agc gtg ttg gac ttg ggt ggg agt ggt aac ccg ttc gct cac ctg 13781 Ser Val Leu Asp Leu Gly Gly Ser Gly Asn Pro Phe Ala His Leu 1150 1155 1160 cgc ccc cgc atc ggg cgc atg atg taagagaaac cgaaaataaa 13825 Arg Pro Arg Ile Gly Arg Met Met 1165 1170 tgatactcac caaggccatg gcgaccagcg tgcgttcgtt tcttctctgt tgttgtatct 13885 agt atg atg agg cgt gcg tac ccg gag ggt cct cct ccc tcg tac 13930 Met Met Arg Arg Ala Tyr Pro Glu Gly Pro Pro Pro Ser Tyr 1175 1180 1185 gag agc gtg atg cag cag gcg atg gcg gcg gcg gcg gcg atg cag 13975 Glu Ser Val Met Gln Gln Ala Met Ala Ala Ala Ala Ala Met Gln 1190 1195 1200 ccc ccg ctg gag gct cct tac gtg ccc ccg cgg tac ctg gcg cct 14020 Pro Pro Leu Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro 1205 1210 1215 acg gag ggg cgg aac agc att cgt tac tcg gag ctg gca ccc ttg 14065 Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu 1220 1225 1230 tac gat acc acc cgg ttg tac ctg gtg gac aac aag tcg gcg gac 14110 Tyr Asp Thr Thr Arg Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp 1235 1240 1245 atc gcc tcg ctg aac tac cag aac gac cac agc aac ttc ctg acc 14155 Ile Ala Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr 1250 1255 1260 acc gtg gtg cag aac aat gac ttc acc ccc acg gag gcc agc acc 14200 Thr Val Val Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr 1265 1270 1275 cag acc atc aac ttt gac gag cgc tcg cgg tgg ggc ggt cag ctg 14245 Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu 1280 1285 1290 aaa acc atc atg cac acc aac atg ccc aac gtg aac gag ttc atg 14290 Lys Thr Ile Met His Thr Asn Met Pro Asn Val Asn Glu Phe Met 1295 1300 1305 tac agc aac aag ttc aag gcg cgg gtg atg gtc tcc cgc aag acc 14335 Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser Arg Lys Thr 1310 1315 1320 ccc aac ggg gtg aca gtg aca gat ggt agt cag gat atc ttg gag 14380 Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln Asp Ile Leu Glu 1325 1330 1335 tat gaa tgg gtg gag ttt gag ctg ccc gaa ggc aac ttc tcg gtg 14425 Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn Phe Ser Val 1340 1345 1350 acc atg acc atc gac ctg atg aac aac gcc atc atc gac aat tac 14470 Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr 1355 1360 1365 ttg gcg gtg ggg cgg cag aac ggg gtc ctg gag agc gat atc ggc 14515 Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly 1370 1375 1380 gtg aag ttc gac act agg aac ttc agg ctg ggc tgg gac ccc gtg 14560 Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val 1385 1390 1395 acc gag ctg gtc atg ccc ggg gtg tac acc aac gag gcc ttc cac 14605 Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His 1400 1405 1410 ccc gat att gtc ttg ctg ccc ggc tgc ggg gtg gac ttc acc gag 14650 Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu 1415 1420 1425 agc cgc ctc agc aac ctg ctg ggc att cgc aag agg cag ccc ttc 14695 Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe 1430 1435 1440 cag gag ggc ttc cag atc atg tac gag gat ctg gag ggg ggc aac 14740 Gln Glu Gly Phe Gln Ile Met Tyr Glu Asp Leu Glu Gly Gly Asn 1445 1450 1455 atc ccc gcg ctc ctg gat gtc gac gcc tat gag aaa agc aag gag 14785 Ile Pro Ala Leu Leu Asp Val Asp Ala Tyr Glu Lys Ser Lys Glu 1460 1465 1470 gag agc gcc gcc gcg gcg act gca gct gta gcc acc gcc tct acc 14830 Glu Ser Ala Ala Ala Ala Thr Ala Ala Val Ala Thr Ala Ser Thr 1475 1480 1485 gag gtc agg ggc gat aat ttt gcc agc cct gca gca gtg gca gcg 14875 Glu Val Arg Gly Asp Asn Phe Ala Ser Pro Ala Ala Val Ala Ala 1490 1495 1500 gcc gag gcg gct gaa acc gaa agt aag ata gtc att cag ccg gtg 14920 Ala Glu Ala Ala Glu Thr Glu Ser Lys Ile Val Ile Gln Pro Val 1505 1510 1515 gag aag gat agc aag gac agg agc tac aac gtg ctg ccg gac aag 14965 Glu Lys Asp Ser Lys Asp Arg Ser Tyr Asn Val Leu Pro Asp Lys 1520 1525 1530 ata aac acc gcc tac cgc agc tgg tac ctg gcc tac aac tat ggc 15010 Ile Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly 1535 1540 1545 gac ccc gag aag ggc gtg cgc tcc tgg acg ctg ctc acc acc tcg 15055 Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr Ser 1550 1555 1560 gac gtc acc tgc ggc gtg gag caa gtc tac tgg tcg ctg ccc gac 15100 Asp Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser Leu Pro Asp 1565 1570 1575 atg atg caa gac ccg gtc acc ttc cgc tcc acg cgt caa gtt agc 15145 Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Ser 1580 1585 1590 aac tac ccg gtg gtg ggc gcc gag ctc ctg ccc gtc tac tcc aag 15190 Asn Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val Tyr Ser Lys 1595 1600 1605 agc ttc ttc aac gag cag gcc gtc tac tcg cag cag ctg cgc gcc 15235 Ser Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Ala 1610 1615 1620 ttc acc tcg ctc acg cac gtc ttc aac cgc ttc ccc gag aac cag 15280 Phe Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln 1625 1630 1635 atc ctc gtc cgc ccg ccc gcg ccc acc att acc acc gtc agt gaa 15325 Ile Leu Val Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu 1640 1645 1650 aac gtt cct gct ctc aca gat cac ggg acc ctg ccg ctg cgc agc 15370 Asn Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg Ser 1655 1660 1665 agt atc cgg gga gtc cag cgc gtg acc gtt act gac gcc aga cgc 15415 Ser Ile Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg 1670 1675 1680 cgc acc tgc ccc tac gtc tac aag gcc ctg ggc ata gtc gcg ccg 15460 Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val Ala Pro 1685 1690 1695 cgc gtc ctc tcg agc cgc acc ttc taaaaa atg tcc att ctc atc tcg 15508 Arg Val Leu Ser Ser Arg Thr Phe Met Ser Ile Leu Ile Ser 1700 1705 ccc agt aat aac acc ggt tgg ggc ctg cgc gcg ccc agc aag atg 15553 Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg Ala Pro Ser Lys Met 1710 1715 1720 tac gga ggc gct cgc caa cgc tcc acg caa cac ccc gtg cgc gtg 15598 Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His Pro Val Arg Val 1725 1730 1735 cgc ggg cac ttc cgc gct ccc tgg ggc gcc ctc aag ggc cgc gtg 15643 Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys Gly Arg Val 1740 1745 1750 cgg tcg cgc acc acc gtc gac gac gtg atc gac cag gtg gtg gcc 15688 Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val Val Ala 1755 1760 1765 gac gcg cgc aac tac acc ccc gcc gcc gcg ccc gtc tcc acc gtg 15733 Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Val Ser Thr Val 1770 1775 1780 gac gcc gtc atc gac agc gtg gtg gcc gac gcg cgc cgg tac gcc 15778 Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 1785 1790 1795 cgc gcc aag agc cgg cgg cgg cgc atc gcc cgg cgg cac cgg agc 15823 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser 1800 1805 1810 acc ccc gcc atg cgc gcg gcg cga gcc ttg ctg cgc agg gcc agg 15868 Thr Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg 1815 1820 1825 cgc acg gga cgc agg gcc atg ctc agg gcg gcc aga cgc gcg gcc 15913 Arg Thr Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala 1830 1835 1840 tca ggc gcc agc gcc ggc agg acc cgg aga cgc gcg gcc acg gcg 15958 Ser Gly Ala Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala 1845 1850 1855 gcg gca gcg gcc atc gcc agc atg tcc cgc ccg cgg cga ggg aac 16003 Ala Ala Ala Ala Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn 1860 1865 1870 gtg tac tgg gtg cgc gac gcc gcc acc ggt gtg cgc gtg ccc gtg 16048 Val Tyr Trp Val Arg Asp Ala Ala Thr Gly Val Arg Val Pro Val 1875 1880 1885 cgc acc cgc ccc cct cgc act tgaagatgtt cacttcgcga tgttgatgtg 16099 Arg Thr Arg Pro Pro Arg Thr 1890 1895 tcccagcggc gagg atg tcc aag cgc aaa ttc aag gaa gag atg ctc cag 16149 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln 1900 1905 gtc atc gcg cct gag atc tac ggc ccc gcg gtg gtg aag gag gaa 16194 Val Ile Ala Pro Glu Ile Tyr Gly Pro Ala Val Val Lys Glu Glu 1910 1915 1920 aga aag ccc cgc aaa atc aag cgg gtc aaa aag gac aaa aag gaa 16239 Arg Lys Pro Arg Lys Ile Lys Arg Val Lys Lys Asp Lys Lys Glu 1925 1930 1935 gaa gaa agt gat gtg gac gga ctg gtg gag ttt gtg cgc gag ttc 16284 Glu Glu Ser Asp Val Asp Gly Leu Val Glu Phe Val Arg Glu Phe 1940 1945 1950 gcc ccc cgg cgg cgc gtg cag tgg cgc ggg cgg aag gtg cgc ccg 16329 Ala Pro Arg Arg Arg Val Gln Trp Arg Gly Arg Lys Val Arg Pro 1955 1960 1965 gtg ctg aga cca ggc act acg gtg gtc ttc acg ccc ggc gag cgc 16374 Val Leu Arg Pro Gly Thr Thr Val Val Phe Thr Pro Gly Glu Arg 1970 1975 1980 tcc ggc acc gct tcc aag cgc tcc tac gac gag gtg tac ggg gac 16419 Ser Gly Thr Ala Ser Lys Arg Ser Tyr Asp Glu Val Tyr Gly Asp 1985 1990 1995 gag gac atc ctc gag cag gcg gcc gag cgc ctg ggc gag ttt gct 16464 Glu Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu Gly Glu Phe Ala 2000 2005 2010 tac ggc aag cgc agc cgc tcc gcg ccg aag gaa gag gcg gtg tcc 16509 Tyr Gly Lys Arg Ser Arg Ser Ala Pro Lys Glu Glu Ala Val Ser 2015 2020 2025 atc ccg ctg gac cac ggc aac ccc acg ccg agc ctc aag ccc gtg 16554 Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu Lys Pro Val 2030 2035 2040 acc ctg cag cag gtg ctg ccg acc gcg gcg ccg cgc cgg ggg ttc 16599 Thr Leu Gln Gln Val Leu Pro Thr Ala Ala Pro Arg Arg Gly Phe 2045 2050 2055 aag cgc gag ggc gag gat ctg tac ccc acc atg cag ctg atg gtg 16644 Lys Arg Glu Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met Val 2060 2065 2070 ccc aag cgc cag aag ctg gaa gac gtg ctg gag acc atg aag gtg 16689 Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu Thr Met Lys Val 2075 2080 2085 gac ccg gac gtg cag ccc gag gtc aag gtg cgg ccc atc aag cag 16734 Asp Pro Asp Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln 2090 2095 2100 gtg gcc ccg ggc ctg ggc gtg cag acc gtg gac atc aag atc ccc 16779 Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro 2105 2110 2115 acg gag ccc atg gaa acg cag acc gag ccc gtg aaa ccc agc acc 16824 Thr Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr 2120 2125 2130 agc acc atg gag gtg cag acg gat cct tgg atg cca tcg gct act 16869 Ser Thr Met Glu Val Gln Thr Asp Pro Trp Met Pro Ser Ala Thr 2135 2140 2145 agc cga aga ccc cgg cgc aag tac ggc gcg gcc agc ctg ctg atg 16914 Ser Arg Arg Pro Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met 2150 2155 2160 ccc aac tac gcg ctg cat cct tcc atc atc ccc acg ccg ggc tac 16959 Pro Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr 2165 2170 2175 cgc ggc acg cgc ttc tac cgc ggt cat aca agc cgc cgc cgc aag 17004 Arg Gly Thr Arg Phe Tyr Arg Gly His Thr Ser Arg Arg Arg Lys 2180 2185 2190 acc acc acc cgc cgc cgc cgt cgc cgc aca acc gct gct gca tct 17049 Thr Thr Thr Arg Arg Arg Arg Arg Arg Thr Thr Ala Ala Ala Ser 2195 2200 2205 acc cct gcc gcc ctg gtg cgg aga gtg tac cgc cgc ggc cgc gcg 17094 Thr Pro Ala Ala Leu Val Arg Arg Val Tyr Arg Arg Gly Arg Ala 2210 2215 2220 cct ctg acc ctg ccg cgc gcg cgc tac cac ccg agc att gcc att 17139 Pro Leu Thr Leu Pro Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 2225 2230 2235 taaactttcg cctgctttgc agatca atg gcc ctc aca tgc cgc ctc cgc 17189 Met Ala Leu Thr Cys Arg Leu Arg 2240 2245 gtt ccc att acg ggc tac cga gga aga aaa ccg cgc cgt aga agg 17234 Val Pro Ile Thr Gly Tyr Arg Gly Arg Lys Pro Arg Arg Arg Arg 2250 2255 2260 ctg gcg ggg aac ggg atg cgt cgc cac cac cac cgg cgg cgg cgc 17279 Leu Ala Gly Asn Gly Met Arg Arg His His His Arg Arg Arg Arg 2265 2270 2275 gcc atc agc aag cgg ttg ggg gga ggc ttc ctg ccc gcg ctg atc 17324 Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe Leu Pro Ala Leu Ile 2280 2285 2290 ccc atc atc gcc gcg gcg atc ggg gcg atc ccc ggc att gct tcc 17369 Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro Gly Ile Ala Ser 2295 2300 2305 gtg gcg gtg cag gcc tct cag cgc cac tgagacacac ttggaaacat 17416 Val Ala Val Gln Ala Ser Gln Arg His 2310 2315 cttgtaataa acca atg gac tct gac gct cct ggt cct gtg atg tgt ttt 17466 Met Asp Ser Asp Ala Pro Gly Pro Val Met Cys Phe 2320 2325 cgt aga cag atg gaa gac atc aat ttt tcg tcc ctg gct ccg cga 17511 Arg Arg Gln Met Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg 2330 2335 2340 cac ggc acg cgg ccg ttc atg ggc acc tgg agc gac atc ggc acc 17556 His Gly Thr Arg Pro Phe Met Gly Thr Trp Ser Asp Ile Gly Thr 2345 2350 2355 agc caa ctg aac ggg ggc gcc ttc aat tgg agc agt ctc tgg agc 17601 Ser Gln Leu Asn Gly Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser 2360 2365 2370 ggg ctt aag aat ttc ggg tcc acg ctt aaa acc tat ggc agc aag 17646 Gly Leu Lys Asn Phe Gly Ser Thr Leu Lys Thr Tyr Gly Ser Lys 2375 2380 2385 gcg tgg aac agc acc aca ggg cag gcg ctg agg gat aag ctg aaa 17691 Ala Trp Asn Ser Thr Thr Gly Gln Ala Leu Arg Asp Lys Leu Lys 2390 2395 2400 gag cag aac ttc cag cag aag gtg gtc gat ggc ctg gcc tcg ggc 17736 Glu Gln Asn Phe Gln Gln Lys Val Val Asp Gly Leu Ala Ser Gly 2405 2410 2415 atc aac ggg gtg gtg gac ctg gcc aac cag gcc gtg cag cgg cag 17781 Ile Asn Gly Val Val Asp Leu Ala Asn Gln Ala Val Gln Arg Gln 2420 2425 2430 atc aac agc cgc ctg gac ccg gtg ccg ccc gcc ggc tcc gtg gag 17826 Ile Asn Ser Arg Leu Asp Pro Val Pro Pro Ala Gly Ser Val Glu 2435 2440 2445 atg ccg cag gtg gag gag gag ctg cct ccc ctg gac aag cgg ggc 17871 Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu Asp Lys Arg Gly 2450 2455 2460 gag aag cga ccc cgc ccc gac gcg gag gag acg ctg ctg acg cac 17916 Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu Leu Thr His 2465 2470 2475 acg gac gag ccg ccc ccg tac gag gag gcg gtg aaa ctg ggc ctg 17961 Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu Gly Leu 2480 2485 2490 ccc acc acg cgg ccc atc gcg cct ctg gcc acc ggg gtg ctg aaa 18006 Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu Lys 2495 2500 2505 ccc gaa agt agt aag ccc gcg acc ctg gac ttg cct cct ccc cag 18051 Pro Glu Ser Ser Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Gln 2510 2515 2520 cct tcc cgc ccc tcc aca gtg gct aag cct ctg ccg ccg gtg gcc 18096 Pro Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala 2525 2530 2535 gtg gcc cgc gcg cga ccc ggg ggc acc gcc cgc cct cat gcg aac 18141 Val Ala Arg Ala Arg Pro Gly Gly Thr Ala Arg Pro His Ala Asn 2540 2545 2550 tgg cag agc act ctg aac agc atc gtg ggt ctg gga gtg cag agt 18186 Trp Gln Ser Thr Leu Asn Ser Ile Val Gly Leu Gly Val Gln Ser 2555 2560 2565 gtg aag cgc cgc cgc tgc tat taaacctacc gtagcgctta acttgcttgt 18237 Val Lys Arg Arg Arg Cys Tyr 2570 ctgtgtgtgt atgtattatg tcgccgccgc tgtcgccaga aggaggagtg aagaggcgcg 18297 tcgccgagtt gcaag atg gcc acc cca tcg atg ctg ccc cag tgg gcg 18345 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala 2575 2580 2585 tac atg cac atc gcc gga cag gac gct tcg gag tac ctg agt ccg 18390 Tyr Met His Ile Ala Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro 2590 2595 2600 ggt ctg gtg cag ttc gcc cgc gcc aca gac acc tac ttc agt ctg 18435 Gly Leu Val Gln Phe Ala Arg Ala Thr Asp Thr Tyr Phe Ser Leu 2605 2610 2615 ggg aac aag ttt agg aac ccc acg gtg gcg ccc acg cac gat gtg 18480 Gly Asn Lys Phe Arg Asn Pro Thr Val Ala Pro Thr His Asp Val 2620 2625 2630 acc acc gac cgc agc cag cgg ctg acg ctg cgc ttc gtg ccc gtg 18525 Thr Thr Asp Arg Ser Gln Arg Leu Thr Leu Arg Phe Val Pro Val 2635 2640 2645 gac cgc gag gac aac acc tac tcg tac aaa gtg cgc tac acg ctg 18570 Asp Arg Glu Asp Asn Thr Tyr Ser Tyr Lys Val Arg Tyr Thr Leu 2650 2655 2660 gcc gtg ggc gac aac cgc gtg ctg gac atg gcc agc acc tac ttt 18615 Ala Val Gly Asp Asn Arg Val Leu Asp Met Ala Ser Thr Tyr Phe 2665 2670 2675 gac atc cgc ggc gtg ctg gac cgg ggc cct agc ttc aaa ccc tac 18660 Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser Phe Lys Pro Tyr 2680 2685 2690 tcc ggc acc gcc tac aat gct ctg gcc ccc aag gga gca ccc aac 18705 Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly Ala Pro Asn 2695 2700 2705 act tgc cag tgg aca tac aca gat aag caa acc gaa aaa aca gcc 18750 Thr Cys Gln Trp Thr Tyr Thr Asp Lys Gln Thr Glu Lys Thr Ala 2710 2715 2720 acg tat ggg aat gcg cct gta caa ggc att gcc atc aca aaa gat 18795 Thr Tyr Gly Asn Ala Pro Val Gln Gly Ile Ala Ile Thr Lys Asp 2725 2730 2735 ggt att caa ctt gga act gac agt gat gga aat cct gta tat gct 18840 Gly Ile Gln Leu Gly Thr Asp Ser Asp Gly Asn Pro Val Tyr Ala 2740 2745 2750 caa aag aca ttt gaa ccc gaa cct caa gtg ggt gat gca gaa tgg 18885 Gln Lys Thr Phe Glu Pro Glu Pro Gln Val Gly Asp Ala Glu Trp 2755 2760 2765 cat gac act aca ggt aca gat gaa aag tat gga ggc agg gca ctt 18930 His Asp Thr Thr Gly Thr Asp Glu Lys Tyr Gly Gly Arg Ala Leu 2770 2775 2780 aag cct gac acc aaa atg aag cct tgc tat ggt tct ttt gcc aaa 18975 Lys Pro Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys 2785 2790 2795 ccc act aac aaa gaa ggt gga cag gca aag aac aga aca aaa act 19020 Pro Thr Asn Lys Glu Gly Gly Gln Ala Lys Asn Arg Thr Lys Thr 2800 2805 2810 gat gga act ggc gaa gag cct gat att gat atg gca ttt ttt gac 19065 Asp Gly Thr Gly Glu Glu Pro Asp Ile Asp Met Ala Phe Phe Asp 2815 2820 2825 ggc aga aat gca act aca gct ggt ttg gct cca gaa att gtt ttg 19110 Gly Arg Asn Ala Thr Thr Ala Gly Leu Ala Pro Glu Ile Val Leu 2830 2835 2840 tat act gag aat gtg gat ctg gag act cca gat acc cat att gta 19155 Tyr Thr Glu Asn Val Asp Leu Glu Thr Pro Asp Thr His Ile Val 2845 2850 2855 tac aaa gca ggc aca gat gac agc agc tct tcg att aat ttg ggg 19200 Tyr Lys Ala Gly Thr Asp Asp Ser Ser Ser Ser Ile Asn Leu Gly 2860 2865 2870 cag caa tcc atg ccc aac aga ccc aac tac att ggg ttc aga gac 19245 Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp 2875 2880 2885 aac ttt atc ggg ctc atg tac tac aac agc act ggc aat atg ggg 19290 Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly 2890 2895 2900 gtg ctg gcc ggt cag gct tct cag ctg aat gct gtg gtt gac ttg 19335 Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu 2905 2910 2915 caa gac aga aac acc gaa ctg tcc tac cag ctc ttg ctt gac tct 19380 Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser 2920 2925 2930 ctg ggc gac aga acc ctg tat ttc agt atg tgg aat cag gcg gtg 19425 Leu Gly Asp Arg Thr Leu Tyr Phe Ser Met Trp Asn Gln Ala Val 2935 2940 2945 gac agc tat gat cct gat gtg cgc att att gaa aac cat ggt gtg 19470 Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Val 2950 2955 2960 gaa gat gaa ctt ccc aac tat tgc ttc cct ctg gat gct gtt ggt 19515 Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asp Ala Val Gly 2965 2970 2975 agg aca gat act tat cag gga att aag ccc aat gga ggc gat cca 19560 Arg Thr Asp Thr Tyr Gln Gly Ile Lys Pro Asn Gly Gly Asp Pro 2980 2985 2990 gcc aca tgg gcc aaa gat gac agc gcc aat gat gct aat gaa atg 19605 Ala Thr Trp Ala Lys Asp Asp Ser Ala Asn Asp Ala Asn Glu Met 2995 3000 3005 ggc aag ggc aat cca ttc gcc atg gaa atc aac atc caa gcc aac 19650 Gly Lys Gly Asn Pro Phe Ala Met Glu Ile Asn Ile Gln Ala Asn 3010 3015 3020 ctg tgg agg aac ttc ctc tac gcc aac gtg gcc ctg tac cta ccc 19695 Leu Trp Arg Asn Phe Leu Tyr Ala Asn Val Ala Leu Tyr Leu Pro 3025 3030 3035 gat tct tac aag tac acg ccg gcc aac gtc acc ctg ccc acc aac 19740 Asp Ser Tyr Lys Tyr Thr Pro Ala Asn Val Thr Leu Pro Thr Asn 3040 3045 3050 acc aac acc tac gat tat atg aac ggc cgg gtg gtg gcg cct tcg 19785 Thr Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val Val Ala Pro Ser 3055 3060 3065 ctg gtg gac tcc tac atc aac atc ggg gcg cgc tgg tcg ctg gac 19830 Leu Val Asp Ser Tyr Ile Asn Ile Gly Ala Arg Trp Ser Leu Asp 3070 3075 3080 ccc atg gac aac gtc aat ccc ttc aac cac cac cgc aac gcg ggc 19875 Pro Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly 3085 3090 3095 ttg cgc tac cgc tcc atg ctc ctg ggc aac ggg cgc tac gtg ccc 19920 Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro 3100 3105 3110 ttc cac atc cag gtg ccc cag aaa ttt ttc gcc atc aag agc ctc 19965 Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu 3115 3120 3125 ctg ctc ctg ccc ggg tcc tac acc tac gag tgg aac ttc cgc aag 20010 Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys 3130 3135 3140 gac gtc aac atg atc ctg cag agc tcc ctc ggc aac gac ctg cgc 20055 Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg 3145 3150 3155 acg gac ggg gcc tcc atc tcc ttc acc agc atc aac ctc tac gcc 20100 Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala 3160 3165 3170 acc ttc ttc ccc atg gcg cac aac acg gcc tcc acg ctc gag gcc 20145 Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala 3175 3180 3185 atg ctg cgc aac gac acc aac gac cag tcc ttc aac gac tac ctc 20190 Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu 3190 3195 3200 tcg gcg gcc aac atg ctc tac ccc atc ccg gcc aac gcc acc aac 20235 Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn 3205 3210 3215 gtg ccc atc tcc atc ccc tcg cgc aac tgg gcc gcc ttc cgc ggc 20280 Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly 3220 3225 3230 tgg tcc ttc acg cgc ctc aag acc aag gag acg ccc tcg ctg ggc 20325 Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly 3235 3240 3245 tcc ggg ttc gac ccc tac ttc gtc tac tcg ggc tcc atc ccc tac 20370 Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr 3250 3255 3260 ctc gac ggc acc ttc tac ctc aac cac acc ttc aag aag gtc tcc 20415 Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser 3265 3270 3275 atc acc ttc gac tcc tcc gtc agc tgg ccc ggc aac gac cgg ctc 20460 Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu 3280 3285 3290 ctg acg ccc aac gag ttc gaa atc aag cgc acc gtc gac ggc gag 20505 Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu 3295 3300 3305 ggc tac aac gtg gcc cag tgc aac atg acc aag gac tgg ttc ctg 20550 Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu 3310 3315 3320 gtc cag atg ctg gcc cac tac aac atc ggc tac cag ggc ttc tac 20595 Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr 3325 3330 3335 gtg ccc gag ggc tac aag gac cgc atg tac tcc ttc ttc cgc aac 20640 Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn 3340 3345 3350 ttc cag ccc atg agc cgc cag gtg gtg gac gag gtc aac tac aag 20685 Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Val Asn Tyr Lys 3355 3360 3365 gac tac cag gcc gtc acc ctg gcc tac cag cac aac aac tcg ggc 20730 Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn Asn Ser Gly 3370 3375 3380 ttc gtc ggc tac ctc gcg ccc acc atg cgc cag ggc cag ccc tac 20775 Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln Pro Tyr 3385 3390 3395 ccc gcc aac tac ccg tac ccg ctc atc ggc aag agc gcc gtc acc 20820 Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val Thr 3400 3405 3410 agc gtc acc cag aaa aag ttc ctc tgc gac agg gtc atg tgg cgc 20865 Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met Trp Arg 3415 3420 3425 atc ccc ttc tcc agc aac ttc atg tcc atg ggc gcg ctc acc gac 20910 Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp 3430 3435 3440 ctc ggc cag aac atg ctc tat gcc aac tcc gcc cac gcg cta gac 20955 Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu Asp 3445 3450 3455 atg aat ttc gaa gtc gac ccc atg gat gag tcc acc ctt ctc tat 21000 Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr 3460 3465 3470 gtt gtc ttc gaa gtc ttc gac gtc gtc cga gtg cac cag ccc cac 21045 Val Val Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro His 3475 3480 3485 cgc ggc gtc atc gag gcc gtc tac ctg cgc acc ccc ttc tcg gcc 21090 Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala 3490 3495 3500 ggt aac gcc acc acc taaattgcta cttgc atg atg gct gag gcc gcg 21138 Gly Asn Ala Thr Thr Met Met Ala Glu Ala Ala 3505 3510 ggc tcc ggc gag cag gag ctc agg gcc atc atc cgc gac ctg ggc 21183 Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile Arg Asp Leu Gly 3515 3520 3525 tgc ggg ccc tac ttc ctg ggc acc ttc gat aag cgc ttc ccg gga 21228 Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg Phe Pro Gly 3530 3535 3540 ttc atg gcc ccg cac aag ctg gcc tgc gcc atc gtc aac acg gcc 21273 Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn Thr Ala 3545 3550 3555 ggt cgc gag acc ggg ggc gag cac tgg ctg gcc ttc gcc tgg aac 21318 Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp Asn 3560 3565 3570 ccg cgc tcg aac acc tgc tac ctc ttc gac ccc ttc ggg ttc tcg 21363 Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser 3575 3580 3585 gac gag cgc ctc aag cag atc tac cag ttc gag tac gag ggc ctg 21408 Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu 3590 3595 3600 ctg cgc cgc agc gcc ctg gcc acc gag gac cgc tgc gtc acc ctg 21453 Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu 3605 3610 3615 gaa aag tcc acc cag acc gtg cag ggt ccg cgc tcg gcc gcc tgc 21498 Glu Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys 3620 3625 3630 ggg ctc ttc tgc tgc atg ttc ctg cac gcc ttc gtg cac tgg ccc 21543 Gly Leu Phe Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro 3635 3640 3645 gac cgc ccc atg gac aag aac ccc acc atg aac ttg ctg acg ggg 21588 Asp Arg Pro Met Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly 3650 3655 3660 gtg ccc aac ggc atg ctc cag tcg ccc cag gtg gaa ccc acc ctg 21633 Val Pro Asn Gly Met Leu Gln Ser Pro Gln Val Glu Pro Thr Leu 3665 3670 3675 cgc cgc aac cag gag gcg ctc tac cgc ttc ctc aac tcc cac tcc 21678 Arg Arg Asn Gln Glu Ala Leu Tyr Arg Phe Leu Asn Ser His Ser 3680 3685 3690 gcc tac ttt cgc tcc cac cgc gcg cgc atc gag aag gcc acc gcc 21723 Ala Tyr Phe Arg Ser His Arg Ala Arg Ile Glu Lys Ala Thr Ala 3695 3700 3705 ttc gat cgc atg aac aat caa gac atg taaaccgtgt gtgtatgttt 21770 Phe Asp Arg Met Asn Asn Gln Asp Met 3710 3715 aaaatatctt ttaataaaca gcactttcat gttacacatg catctgagat gattatttag 21830 aaatcgaaag ggttctgccg ggtctcggca tggcccgcgg gcagggacac gttgcggaac 21890 tggtacttgg ccagccactt gaactcgggg atcagcagtt tcggcagcgg ggtgtcgggg 21950 aaggagtcgg tccacagctt ccgcgtcagt tgcagggcgc ccagcaggtc gggcgcggag 22010 atcttgaaat cgcagttggg acccgcgttc tgcgcgcgag agttgcggta cacggggttg 22070 cagcactgga acaccatcag ggccgggtgc ttcacgctcg ccagcaccgt cgcgtcggtg 22130 atgctctcca cgtcgaggtc ctcggcgttg gccatcccga agggggtcat cttgcaggtc 22190 tgccttccca tagtgggcac gcacccgggc ttgtggttgc aatcgcagtg cagggggatc 22250 agcatcatct gggcctggtc ggcgttcatc cccgggtaca tggccttcat gaaagcctcc 22310 aattgcctga aagcctgctg ggccttggct ccctcggtga agaagacccc gcaggacttg 22370 ctagagaact ggttggtagc gcacccggcg tcgtgcacgc agcagcgcgc gtcgttgttg 22430 gccagctgca ccacgctgcg cccccagcgg ttctgggtga tcttggcccg gtcggggttc 22490 tccttcagcg cgcgctgccc gttctcgctc gccacatcca tctcgatcat gtgctccttc 22550 tggatcatgg tggtcccgtg caggcaccgc agcttgccct cggtctcggt gcacccgtgc 22610 agccacagcg cgcacccggt gcactcccag ttcttgtggg cgatctggga atgcgcgtgc 22670 acgaacccct gcaggaagcg gcccatcatg gtggtcaggg tcttgttgct agtgaaggtc 22730 agcgggatgc cgcggtgctc ctcgttgatg tacaggtggc agatgcggcg gtacacctcg 22790 ccctgctcgg gcatcagctg gaagttggct ttcaggtcgg tctccacgcg gtagcggtcc 22850 atcagtatag tcatgatttc catacccttc tcccaggccg agacgatggg caggctcata 22910 gggttcttca ccatcatctt agcactagca gccgcggcca gggggtcgct ctcatccagg 22970 gtctcaaagc tccgcttgcc gtccttctcg gtgatccgca ccggggggta gctgaagccc 23030 acggccgcca gctcctcctc ggcctgcctt tcgtcctcgc tgtcctggct gacgtcctgc 23090 aggaccacat gcttggtctt gcggggtttc ttcttgggcg gcagcggcgg cggagatgct 23150 tgtggcgagg gggagcgcga gttctcgctc accactacta tctcttcctc ttcgtggtcc 23210 gaggccacgc ggcggtaggt atgtctcttc gggggcagag gcggaggcga cgggctctcg 23270 ccgccgcgac ttggcggatg gctggcagag ccccttccgc gatcgggggt gcgctcccgg 23330 cggcgctctg actgacttcc tccgcggccg gccattgtgt tctcctaggg aggaacaaca 23390 agc atg gag act cag cca tcg cca acc tcg cca tct gcc ccc acc 23435 Met Glu Thr Gln Pro Ser Pro Thr Ser Pro Ser Ala Pro Thr 3720 3725 acc gcc gac gag aag cag cag aat gaa agc tta acc gcc ccg ccg 23480 Thr Ala Asp Glu Lys Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro 3730 3735 3740 ccc agc ccc gcc acc tcc gac gca gcc gcg gtc cca gac atg caa 23525 Pro Ser Pro Ala Thr Ser Asp Ala Ala Ala Val Pro Asp Met Gln 3745 3750 3755 gag atg gag gaa tcc atc gag att gac ctg ggc tat gtg acg ccc 23570 Glu Met Glu Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro 3760 3765 3770 gcg gag cac gag gag gag ctg gca gtg cgc ttt caa tcg tca agc 23615 Ala Glu His Glu Glu Glu Leu Ala Val Arg Phe Gln Ser Ser Ser 3775 3780 3785 cag gaa gat aaa gaa cag cca gag cag gaa gca gaa aac gag cag 23660 Gln Glu Asp Lys Glu Gln Pro Glu Gln Glu Ala Glu Asn Glu Gln 3790 3795 3800 agt cag gct ggg ctc gag cat gac ggc gac tac ctc cac ctg agc 23705 Ser Gln Ala Gly Leu Glu His Asp Gly Asp Tyr Leu His Leu Ser 3805 3810 3815 ggg gag gag gac gcg ctc atc aag cat ctg gcc cgg cag gcc atc 23750 Gly Glu Glu Asp Ala Leu Ile Lys His Leu Ala Arg Gln Ala Ile 3820 3825 3830 atc gtc aag gat gcg ctg ctc gac cgc acc gag gtg ccc ctc agc 23795 Ile Val Lys Asp Ala Leu Leu Asp Arg Thr Glu Val Pro Leu Ser 3835 3840 3845 gtg gag gag ctc agc cgc gcc tac gag ctc aac ctc ttc tcg ccg 23840 Val Glu Glu Leu Ser Arg Ala Tyr Glu Leu Asn Leu Phe Ser Pro 3850 3855 3860 cgc gtg ccc ccc aag cgc cag ccc aac ggc acc tgc gag ccc aac 23885 Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys Glu Pro Asn 3865 3870 3875 ccg cgc ctc aac ttc tac ccg gtc ttc gcg gtg ccc gag gcc ctg 23930 Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu Ala Leu 3880 3885 3890 gcc acc tac cac atc ttt ttc aag aac caa aag atc ccc gtc tcc 23975 Ala Thr Tyr His Ile Phe Phe Lys Asn Gln Lys Ile Pro Val Ser 3895 3900 3905 tgt cgc gcc aac cgc acc cgc gcc gac gcc ctc ttc aac ctg ggc 24020 Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Phe Asn Leu Gly 3910 3915 3920 ccc ggc gcc cgc cta cct gat atc gcc tcc ttg gaa gag gtt ccc 24065 Pro Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro 3925 3930 3935 aag atc ttc gag ggt ctg ggc agc gac gag act cgg gcc gca aac 24110 Lys Ile Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn 3940 3945 3950 gct ctg caa gga gaa gga gga gag cat gag cac cac agc gcc ctg 24155 Ala Leu Gln Gly Glu Gly Gly Glu His Glu His His Ser Ala Leu 3955 3960 3965 gtc gag ttg gaa ggc gac aac gcg cgg ctg gcg gtg ctc aaa cgc 24200 Val Glu Leu Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg 3970 3975 3980 acg gtc gag ctg acc cat ttc gcc tac ccg gct ctg aac ctg ccc 24245 Thr Val Glu Leu Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro 3985 3990 3995 ccc aaa gtc atg agc gcg gtc atg gac cag gtg ctc atc aag cgc 24290 Pro Lys Val Met Ser Ala Val Met Asp Gln Val Leu Ile Lys Arg 4000 4005 4010 gcg tcg ccc atc tcc gag gac gag ggc atg caa gac tcc gag gat 24335 Ala Ser Pro Ile Ser Glu Asp Glu Gly Met Gln Asp Ser Glu Asp 4015 4020 4025 ggc aag ccc gtg gtc agc gac gag cag ctg gcc cgg tgg ctg ggt 24380 Gly Lys Pro Val Val Ser Asp Glu Gln Leu Ala Arg Trp Leu Gly 4030 4035 4040 cct aat gct agt ccc cag agt ttg gaa gag cgg cgc aag ctc atg 24425 Pro Asn Ala Ser Pro Gln Ser Leu Glu Glu Arg Arg Lys Leu Met 4045 4050 4055 atg gcc gtg gtc ctg gtg acc gtg gag ctg gag tgc ctg cgc cgc 24470 Met Ala Val Val Leu Val Thr Val Glu Leu Glu Cys Leu Arg Arg 4060 4065 4070 ttc ttc gcc gac gcg gag acc ctg cgc aag gtc gag gag aac ctg 24515 Phe Phe Ala Asp Ala Glu Thr Leu Arg Lys Val Glu Glu Asn Leu 4075 4080 4085 cac tac ctc ttc agg cac ggg ttc gtg cgc cag gcc tgc aag atc 24560 His Tyr Leu Phe Arg His Gly Phe Val Arg Gln Ala Cys Lys Ile 4090 4095 4100 tcc aac gtg gag ctg acc aac ctg gtc tcc tac atg ggc atc ttg 24605 Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr Met Gly Ile Leu 4105 4110 4115 cac gag aac cgc ctg ggg cag aac gtg ctg cac acc acc ctg cgc 24650 His Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr Thr Leu Arg 4120 4125 4130 ggg gag gcc cgc cgc gac tac atc cgc gac tgc gtc tac ctc tac 24695 Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr Leu Tyr 4135 4140 4145 ctc tgc cac acc tgg cag acg ggc atg ggc gtg tgg cag cag tgt 24740 Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln Gln Cys 4150 4155 4160 ctg gag gag cag aac ctg aaa gag ctc tgc aag ctc ctg cag aag 24785 Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys 4165 4170 4175 aac ctc aag ggt ctg tgg acc ggg ttc gac gag cgg acc acc gcc 24830 Asn Leu Lys Gly Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala 4180 4185 4190 tcg gac ctg gcc gac ctc atc ttc ccc gag cgc ctc agg ctg acg 24875 Ser Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr 4195 4200 4205 ctg cgc aac ggc ctg ccc gac ttt atg agc caa agc atg ttg caa 24920 Leu Arg Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln 4210 4215 4220 aac ttt cgc tct ttc atc ctc gaa cgc tcc gga atc ctg ccc gcc 24965 Asn Phe Arg Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala 4225 4230 4235 acc tgc tcc gcg ctg ccc tcg gac ttc gtg ccg ctg acc ttc cgc 25010 Thr Cys Ser Ala Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg 4240 4245 4250 gag tgc ccc ccg ccg ctg tgg agc cac tgc tac ctg ctg cgc ctg 25055 Glu Cys Pro Pro Pro Leu Trp Ser His Cys Tyr Leu Leu Arg Leu 4255 4260 4265 gcc aac tac ctg gcc tac cac tcg gac gtg atc gag gac gtc agc 25100 Ala Asn Tyr Leu Ala Tyr His Ser Asp Val Ile Glu Asp Val Ser 4270 4275 4280 ggc gag ggc ctg ctt gag tgc cac tgc cgc tgc aac ctc tgc acg 25145 Gly Glu Gly Leu Leu Glu Cys His Cys Arg Cys Asn Leu Cys Thr 4285 4290 4295 ccg cac cgc tcc ctg gcc tgc aac ccc cag ctg ctg agc gag acc 25190 Pro His Arg Ser Leu Ala Cys Asn Pro Gln Leu Leu Ser Glu Thr 4300 4305 4310 cag atc atc ggc acc ttc gag ttg caa ggg ccc agc gat gac ggc 25235 Gln Ile Ile Gly Thr Phe Glu Leu Gln Gly Pro Ser Asp Asp Gly 4315 4320 4325 gag gga gcc aag ggg ggt ctg aaa ctc acc ccg ggg ctg tgg acc 25280 Glu Gly Ala Lys Gly Gly Leu Lys Leu Thr Pro Gly Leu Trp Thr 4330 4335 4340 tcg gcc tac ttg cgc aag ttc gtg ccc gag gac tac cat ccc ttc 25325 Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr His Pro Phe 4345 4350 4355 gag atc agg ttc tac gag gac caa tcc cag ccg cct aag gcc gag 25370 Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys Ala Glu 4360 4365 4370 ctg tcg gcc tgc gtc atc acc cag ggg gcc atc ctg gcc caa ttg 25415 Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala Gln Leu 4375 4380 4385 caa gcc atc cag aaa tcc cgc caa gaa ttc ttg ctg aaa aag ggc 25460 Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly 4390 4395 4400 cgc ggg gtc tac ctc gac ccc cag acc ggt gag gag ctc aac ccc 25505 Arg Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro 4405 4410 4415 ggc ttc ccc cag gat gcc ccg agg aaa caa gaa gct gaa agt gga 25550 Gly Phe Pro Gln Asp Ala Pro Arg Lys Gln Glu Ala Glu Ser Gly 4420 4425 4430 gct gcc gcc cgt gga gga ttt gga gga aga ctg gga gaa cag cag 25595 Ala Ala Ala Arg Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Gln 4435 4440 4445 tca ggc aga gga gga gat gga gga aga ctg gga cag cac tca ggc 25640 Ser Gly Arg Gly Gly Asp Gly Gly Arg Leu Gly Gln His Ser Gly 4450 4455 4460 aga gga gga cag cct gca aga cag tct gga gga aga cga gga gga 25685 Arg Gly Gly Gln Pro Ala Arg Gln Ser Gly Gly Arg Arg Gly Gly 4465 4470 4475 ggc aga ggt gga aga agc agc cgc cgc cag acc gtc gtc ctc ggc 25730 Gly Arg Gly Gly Arg Ser Ser Arg Arg Gln Thr Val Val Leu Gly 4480 4485 4490 ggg gga gaa agc aag cag cac gga tac cat ctc cgc tcc ggg tcg 25775 Gly Gly Glu Ser Lys Gln His Gly Tyr His Leu Arg Ser Gly Ser 4495 4500 4505 ggg tcc cgc tcg gcc cca cag tagatgggac gagaccgggc gattcccgaa 25826 Gly Ser Arg Ser Ala Pro Gln 4510 4515 ccccaccatc cagaccggta agaaggagcg gcagggatac aagtcctggc gggggcacaa 25886 aaacgccatc gtctcctgct tgcaggcctg cgggggcaac atctccttca ccaggcgcta 25946 cctgctcttc caccgcgggg tgaacttccc ccgcaacatc ttgcattact accgtcacct 26006 ccacagcccc tactacttcc aagaagaggc agcagcagaa aaagaccagc agaaaaccag 26066 cagctagaaa atccacagcg gcagcaggtg gactgaggat cgcggcgaac gagccggcgc 26126 agacccggga gctgaggaac cggatctttc ccaccctcta tgccatcttc cagcagagtc 26186 gggggcagga gcaggaactg aaagtcaaga accgttctct gcgctcgctc acccgcagtt 26246 gtctgtatca caagagcgaa gaccaacttc agcgcactct cgaggacgcc gaggctctct 26306 tcaacaagta ctgcgcgctc actcttaaag agtagcccgc gcccgcccag tcgcagaaaa 26366 aggcgggaat tacgtcacct gtgcccttcg ccctagccgc ctccacccat c atg agc 26423 Met Ser aaa gag att ccc acg cct tac atg tgg agc tac cag ccc cag atg 26468 Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln Met 4520 4525 4530 ggc ctg gcc gcc ggc gcc gcc cag gac tac tcc acc cgc atg aat 26513 Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 4535 4540 4545 tgg ctc agc gcc ggg ccc gcg atg atc tca cgg gtg aat gac atc 26558 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile 4550 4555 4560 cgc gcc cac cga aac cag ata ctc cta gaa cag tca gcg ctc acc 26603 Arg Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Leu Thr 4565 4570 4575 gcc acg ccc cgc aat cac ctc aat ccg cgt aat tgg ccc gcc gcc 26648 Ala Thr Pro Arg Asn His Leu Asn Pro Arg Asn Trp Pro Ala Ala 4580 4585 4590 ctg gtg tac cag gaa att ccc cag ccc acg acc gta cta ctt ccg 26693 Leu Val Tyr Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro 4595 4600 4605 cga gac gcc cag gcc gaa gtc cag ctg act aac tca ggt gtc cag 26738 Arg Asp Ala Gln Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln 4610 4615 4620 ctg gcg ggc ggc gcc acc ctg tgt cgt cac cgc ccc gct cag ggt 26783 Leu Ala Gly Gly Ala Thr Leu Cys Arg His Arg Pro Ala Gln Gly 4625 4630 4635 ata aag cgg ctg gtg atc cgg ggc aga ggc aca cag ctc aac gac 26828 Ile Lys Arg Leu Val Ile Arg Gly Arg Gly Thr Gln Leu Asn Asp 4640 4645 4650 gag gtg gtg agc tct tcg ctg ggt ctg cga cct gac gga gtc ttc 26873 Glu Val Val Ser Ser Ser Leu Gly Leu Arg Pro Asp Gly Val Phe 4655 4660 4665 caa atc gcc gga tcg ggg aga tct tcc ttc acg cct cgt cag gcg 26918 Gln Ile Ala Gly Ser Gly Arg Ser Ser Phe Thr Pro Arg Gln Ala 4670 4675 4680 gtc ctg act ttg gag agt tcg tcc tcg cag ccc cgc tcg ggc ggc 26963 Val Leu Thr Leu Glu Ser Ser Ser Ser Gln Pro Arg Ser Gly Gly 4685 4690 4695 atc ggc act ctc cag ttc gtg gag gag ttc act ccc tcg gtc tac 27008 Ile Gly Thr Leu Gln Phe Val Glu Glu Phe Thr Pro Ser Val Tyr 4700 4705 4710 ttc aac ccc ttc tcc ggc tcc ccc ggc cac tac ccg gac gag ttc 27053 Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr Pro Asp Glu Phe 4715 4720 4725 atc ccg aac ttt gac gcc atc agc gag tcg gtg gac ggc tac gat 27098 Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp Gly Tyr Asp 4730 4735 4740 tga atg tcc cat ggt ggc gcg gct gac cta gct cgg ctt cga cac 27143 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His 4745 4750 4755 ctg gac cac tgc cgc cgc ttt cgc tgc ttc gct cgg gac ctc gcc 27188 Leu Asp His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala 4760 4765 4770 gag ttc acc tac ttc gag ctg ccc gag gag cat cct cag ggc ccg 27233 Glu Phe Thr Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro 4775 4780 4785 gcc cac gga gtg cgg atc gtc gtc gaa ggg ggc cta gac tcc cac 27278 Ala His Gly Val Arg Ile Val Val Glu Gly Gly Leu Asp Ser His 4790 4795 4800 ctg ctt cgg atc ttc agc cag cgc ccg atc ctg gtc gag cgc caa 27323 Leu Leu Arg Ile Phe Ser Gln Arg Pro Ile Leu Val Glu Arg Gln 4805 4810 4815 cag ggc aac acc ctc ctg acc ctc tac tgc atc tgc gac cac ccc 27368 Gln Gly Asn Thr Leu Leu Thr Leu Tyr Cys Ile Cys Asp His Pro 4820 4825 4830 ggc ctg cat gaa agt ctt tgt tgt ctg ctg tgt act gag tat aat 27413 Gly Leu His Glu Ser Leu Cys Cys Leu Leu Cys Thr Glu Tyr Asn 4835 4840 4845 aaa agc tgagatcagc gactactccg gactcaactg tggtgtttct gcatccatca 27469 Lys Ser accagtctct gaccttcacc gggaacgaga ccgagctcca gctccagtgt aagccccaca 27529 agaagtacct cacctggctg taccagggct ccccgatcgc cgttgttaac cactgcgacg 27589 acgacggagt cctgctgaac ggccccgcca accttacttt ttccacccgc agaagcaagc 27649 tactgctctt cagacccttc ctccccggga tctatcagtg catctcggga ccctgccatc 27709 acaccttcca cctgatcccg aataccacct cttccccagc accgctcccc actaacaacc 27769 aaactaacca ccaacgccac cgtcgagacc tttcctctga ttctaatacc actaccggag 27829 gtgagctccg aggtactaag aagtcctcac ctgggattta ttacggcccc tgggaggtgg 27889 tggggttaat agctttaggc ttagtagcgg gtgggctttt ggctctctgc tacctatacc 27949 tcccttgctg ttcctactta gtggtgcttt gttgctggtt taagaa atg ggg aag 28004 Met Gly Lys 4850 atc acc cta gtg tgc ggt gtg ctg gtg acg gtg gtg ctt tcg att 28049 Ile Thr Leu Val Cys Gly Val Leu Val Thr Val Val Leu Ser Ile 4855 4860 4865 ctg gga ggg gga agc gcg gct gta gtg acg gag aag aag gcc gat 28094 Leu Gly Gly Gly Ser Ala Ala Val Val Thr Glu Lys Lys Ala Asp 4870 4875 4880 ccc tgc ttg act ttc aat ccc gat aaa tgc cgg ctg agt ttt cag 28139 Pro Cys Leu Thr Phe Asn Pro Asp Lys Cys Arg Leu Ser Phe Gln 4885 4890 4895 cca gat ggc aat cgg tgc acg gtg ctg atc aag tgc gga tgg gaa 28184 Pro Asp Gly Asn Arg Cys Thr Val Leu Ile Lys Cys Gly Trp Glu 4900 4905 4910 tgc gag agc gtg gcg atc cag tat aaa aac aag acg cgg aac aat 28229 Cys Glu Ser Val Ala Ile Gln Tyr Lys Asn Lys Thr Arg Asn Asn 4915 4920 4925 act ctc gcg tcc aca tgg cag ccc ggg gac ccc gag tgg tac acc 28274 Thr Leu Ala Ser Thr Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr 4930 4935 4940 gtc tct gtc cct ggt gct gac ggc tcc ctc cac acg gtg aac aac 28319 Val Ser Val Pro Gly Ala Asp Gly Ser Leu His Thr Val Asn Asn 4945 4950 4955 act ttc att ttt gag cac atg tgc gaa acc gcc atg ttc atg agc 28364 Thr Phe Ile Phe Glu His Met Cys Glu Thr Ala Met Phe Met Ser 4960 4965 4970 aag cag tac ggt atg tgg ccc cca cga aaa gag aat atc gtg gtc 28409 Lys Gln Tyr Gly Met Trp Pro Pro Arg Lys Glu Asn Ile Val Val 4975 4980 4985 ttc tcc atc gct tac agc gcg tgc acg gtg cta atc acc gcg atc 28454 Phe Ser Ile Ala Tyr Ser Ala Cys Thr Val Leu Ile Thr Ala Ile 4990 4995 5000 gtg tgc ctg agc att cac atg ctc atc gct att cgc ccc aga aat 28499 Val Cys Leu Ser Ile His Met Leu Ile Ala Ile Arg Pro Arg Asn 5005 5010 5015 aat gcc gag aaa gag aaa cag cca taacacactt ttttcacaca 28543 Asn Ala Glu Lys Glu Lys Gln Pro 5020 5025 ccttgttttt tacagaca atg cgt ctg tta att ttt gtt atc att aca ctc 28594 Met Arg Leu Leu Ile Phe Val Ile Ile Thr Leu 5030 5035 agc ttt aac tat gcc cat ggc tat gca aat ata caa aaa acc ctc 28639 Ser Phe Asn Tyr Ala His Gly Tyr Ala Asn Ile Gln Lys Thr Leu 5040 5045 5050 tat gta ggc tct gac tct aca tta gaa ggt act caa tct caa gcc 28684 Tyr Val Gly Ser Asp Ser Thr Leu Glu Gly Thr Gln Ser Gln Ala 5055 5060 5065 agg gtt tca tgg tat ttt tat aaa ggc tct gat gac cca att act 28729 Arg Val Ser Trp Tyr Phe Tyr Lys Gly Ser Asp Asp Pro Ile Thr 5070 5075 5080 ctt tgc aaa ggt gat cag ggg cgc ata aca aag cca cct atc aca 28774 Leu Cys Lys Gly Asp Gln Gly Arg Ile Thr Lys Pro Pro Ile Thr 5085 5090 5095 ttt agc tgc acc aga aca aac ctc acg ctt tta tcc att aca aaa 28819 Phe Ser Cys Thr Arg Thr Asn Leu Thr Leu Leu Ser Ile Thr Lys 5100 5105 5110 gaa tat gct ggc act tat tac agc aca aat ttt cat cgt ggg caa 28864 Glu Tyr Ala Gly Thr Tyr Tyr Ser Thr Asn Phe His Arg Gly Gln 5115 5120 5125 gat aaa tat tat act gtt aag gta gaa aac cct acc acc cct aga 28909 Asp Lys Tyr Tyr Thr Val Lys Val Glu Asn Pro Thr Thr Pro Arg 5130 5135 5140 aca act aca aag ccc acc aca act aag aag ccc act aca cct aag 28954 Thr Thr Thr Lys Pro Thr Thr Thr Lys Lys Pro Thr Thr Pro Lys 5145 5150 5155 aag cct acc aca ccc aaa acc act aag aca aca act gct aag acc 28999 Lys Pro Thr Thr Pro Lys Thr Thr Lys Thr Thr Thr Ala Lys Thr 5160 5165 5170 act acc aca aag cca acc aca acc agc acc aca ctt gct ata act 29044 Thr Thr Thr Lys Pro Thr Thr Thr Ser Thr Thr Leu Ala Ile Thr 5175 5180 5185 aca cac aca cac act gag ctg acc tca cag gca act act gaa aat 29089 Thr His Thr His Thr Glu Leu Thr Ser Gln Ala Thr Thr Glu Asn 5190 5195 5200 gat ttg gtt gcc ctg ttg caa aag ggg gag aac agt agc agc agt 29134 Asp Leu Val Ala Leu Leu Gln Lys Gly Glu Asn Ser Ser Ser Ser 5205 5210 5215 cct ctg cct act acc ccc agt gag gaa ata ccc aag tcc atg gtt 29179 Pro Leu Pro Thr Thr Pro Ser Glu Glu Ile Pro Lys Ser Met Val 5220 5225 5230 ggc att atc gct gct gta gtg gtg tgt atg ctg att atc atc ttg 29224 Gly Ile Ile Ala Ala Val Val Val Cys Met Leu Ile Ile Ile Leu 5235 5240 5245 tgc atg atg tac tat gcc tgc tac tac aga aaa cac agg ctg aac 29269 Cys Met Met Tyr Tyr Ala Cys Tyr Tyr Arg Lys His Arg Leu Asn 5250 5255 5260 aac aaa ctg gac ccc tta ctg agt gtt gat ttt taatttttta gaacc 29317 Asn Lys Leu Asp Pro Leu Leu Ser Val Asp Phe 5265 5270 atg aag atc cta agc ctt ttt gtt ttt tct ata att att acc tct 29362 Met Lys Ile Leu Ser Leu Phe Val Phe Ser Ile Ile Ile Thr Ser 5275 5280 5285 gct att tgt gaa tca gtg gat aag gac gtt act gtc acc act ggc 29407 Ala Ile Cys Glu Ser Val Asp Lys Asp Val Thr Val Thr Thr Gly 5290 5295 5300 tct aat tat aca cta aaa ggg cct tcc tca ggt atg ctt tcg tgg 29452 Ser Asn Tyr Thr Leu Lys Gly Pro Ser Ser Gly Met Leu Ser Trp 5305 5310 5315 tat tgt tat ttt gga aat gat gat aaa cag aca gag cta tgt aac 29497 Tyr Cys Tyr Phe Gly Asn Asp Asp Lys Gln Thr Glu Leu Cys Asn 5320 5325 5330 ttt cag aac ggc aaa acc aaa aat tct aaa ata gat aac tat caa 29542 Phe Gln Asn Gly Lys Thr Lys Asn Ser Lys Ile Asp Asn Tyr Gln 5335 5340 5345 tgc cag ggt act aat tta gta ctg atg aat atc acg aaa gca tat 29587 Cys Gln Gly Thr Asn Leu Val Leu Met Asn Ile Thr Lys Ala Tyr 5350 5355 5360 gct ggc agt tat tcc tgt cct gga caa aac acc gag gaa atg att 29632 Ala Gly Ser Tyr Ser Cys Pro Gly Gln Asn Thr Glu Glu Met Ile 5365 5370 5375 ttt tac aaa tta att gta gtt gac cct act act cca gca cca ccc 29677 Phe Tyr Lys Leu Ile Val Val Asp Pro Thr Thr Pro Ala Pro Pro 5380 5385 5390 acc aca acc aag gca cat acc aca gac aca cag gaa acc act cca 29722 Thr Thr Thr Lys Ala His Thr Thr Asp Thr Gln Glu Thr Thr Pro 5395 5400 5405 gag gca gaa gta gca gag tta gca aag cag att cat gaa gat tca 29767 Glu Ala Glu Val Ala Glu Leu Ala Lys Gln Ile His Glu Asp Ser 5410 5415 5420 ttt gtt gcc aat acc ccc aca cac ccc gga ccg caa tgt cca ggg 29812 Phe Val Ala Asn Thr Pro Thr His Pro Gly Pro Gln Cys Pro Gly 5425 5430 5435 cca tta gtc agc ggc att gtc ggt gtg ctt tgc ggg tta gca gtt 29857 Pro Leu Val Ser Gly Ile Val Gly Val Leu Cys Gly Leu Ala Val 5440 5445 5450 ata atc atc tgc atg ttc att ttt gct tgc tgc tac aga agg ctt 29902 Ile Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu 5455 5460 5465 cac cga caa aaa tca gac cca ctg ctg aac ctc tat gtt taatttttga 29951 His Arg Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 5470 5475 5480 ttttccagag cc atg aag gca ctt agc act tta gta ttt ttg tcc ttg 29999 Met Lys Ala Leu Ser Thr Leu Val Phe Leu Ser Leu 5485 5490 att ggc att gtt ttc agt gct ggg ttt ttg aaa aat ctt acc att 30044 Ile Gly Ile Val Phe Ser Ala Gly Phe Leu Lys Asn Leu Thr Ile 5495 5500 5505 att gaa ggt gat aat gca aca ctg gta gga atc agc ggt cag aat 30089 Ile Glu Gly Asp Asn Ala Thr Leu Val Gly Ile Ser Gly Gln Asn 5510 5515 5520 gtt agt tgg cta aaa tat cat cta gat ggg tgg aaa cct att tgc 30134 Val Ser Trp Leu Lys Tyr His Leu Asp Gly Trp Lys Pro Ile Cys 5525 5530 5535 acc tgg aat gtc agt gtg tac aca tgc cat ggt gtt aac ctc acc 30179 Thr Trp Asn Val Ser Val Tyr Thr Cys His Gly Val Asn Leu Thr 5540 5545 5550 att acc aat gcc acc caa gat cag aat ggc agg ttt aag ggt cag 30224 Ile Thr Asn Ala Thr Gln Asp Gln Asn Gly Arg Phe Lys Gly Gln 5555 5560 5565 agt ttc act agc aac aat ggg tat gaa acc cat aac atg ttc atc 30269 Ser Phe Thr Ser Asn Asn Gly Tyr Glu Thr His Asn Met Phe Ile 5570 5575 5580 tat gat gtc act gtc ata tca aat aag act aca cct acc aca cag 30314 Tyr Asp Val Thr Val Ile Ser Asn Lys Thr Thr Pro Thr Thr Gln 5585 5590 5595 aca ccc act aca cat agc tca act cat gcc atg cag acc act cag 30359 Thr Pro Thr Thr His Ser Ser Thr His Ala Met Gln Thr Thr Gln 5600 5605 5610 aca acc aca tac act aca tct act gag tcc acc acc acc act aca 30404 Thr Thr Thr Tyr Thr Thr Ser Thr Glu Ser Thr Thr Thr Thr Thr 5615 5620 5625 gca gag gta tcc agc aca gcg cct cag ccc cag gca ttg gct ttg 30449 Ala Glu Val Ser Ser Thr Ala Pro Gln Pro Gln Ala Leu Ala Leu 5630 5635 5640 atg gct cag cct agc agc atg act gct aaa acc aat gag cag act 30494 Met Ala Gln Pro Ser Ser Met Thr Ala Lys Thr Asn Glu Gln Thr 5645 5650 5655 act gaa ttt ttg tcc act att cag agc agc acc aca gct acc tcg 30539 Thr Glu Phe Leu Ser Thr Ile Gln Ser Ser Thr Thr Ala Thr Ser 5660 5665 5670 agt gcc ttc tct agc acc gcc aat ctc acc tcg ctt tcc tct acg 30584 Ser Ala Phe Ser Ser Thr Ala Asn Leu Thr Ser Leu Ser Ser Thr 5675 5680 5685 cca atc agt aac gct act acc tcc ccc gct cct ctt ccc act cct 30629 Pro Ile Ser Asn Ala Thr Thr Ser Pro Ala Pro Leu Pro Thr Pro 5690 5695 5700 ctg aag caa tcc gag tct agc acg cag ctg cag atc acc ctg ctc 30674 Leu Lys Gln Ser Glu Ser Ser Thr Gln Leu Gln Ile Thr Leu Leu 5705 5710 5715 att gtg atc ggg gtg gtc atc ctg gca gtg ctg ctc tac ttt atc 30719 Ile Val Ile Gly Val Val Ile Leu Ala Val Leu Leu Tyr Phe Ile 5720 5725 5730 ttc tgc cgc cgc atc ccc aac gcg aaa ccg gcc tac aag ccc att 30764 Phe Cys Arg Arg Ile Pro Asn Ala Lys Pro Ala Tyr Lys Pro Ile 5735 5740 5745 gtt atc ggg acg ccg gag ccg ctt cag gtg gag gga ggt cta agg 30809 Val Ile Gly Thr Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg 5750 5755 5760 aat ctt ctc ttc tct ttt aca gta tgg tgatttgaac tatgattcct 30856 Asn Leu Leu Phe Ser Phe Thr Val Trp 5765 5770 agacatttca ttatcacttc tctaatctgt gtgctccaag tctgtgccac cctcgctctc 30916 gtggctaacg cgagtccaga ctgcattgga gcgttcgcct cctacgtgct ctttgccttc 30976 atcacctgca tctgctgctg tagcatagtc tgcctgctta tcaccttctt ccagttcgtt 31036 gactgggtct ttgtgcgcat cgcctacctg cgccaccacc cccagtaccg cgaccagaga 31096 gtggcgcaac tgttgagact catctg atg ata agc atg cgg gct ctg cta 31146 Met Ile Ser Met Arg Ala Leu Leu 5775 cta ctt ctc gcg ctt ctg cta gct ccc ctc gcc gcc ccc cta tcc 31191 Leu Leu Leu Ala Leu Leu Leu Ala Pro Leu Ala Ala Pro Leu Ser 5780 5785 5790 ctc aaa tcc ccc acc cag tcc cct gaa gag gtt cga aaa tgt aaa 31236 Leu Lys Ser Pro Thr Gln Ser Pro Glu Glu Val Arg Lys Cys Lys 5795 5800 5805 ttc caa gaa ccc tgg aaa ttc ctt tca tgc tac aaa ctc aaa tca 31281 Phe Gln Glu Pro Trp Lys Phe Leu Ser Cys Tyr Lys Leu Lys Ser 5810 5815 5820 gaa atg cac ccc agc tgg atc atg atc gtt gga atc gta aac atc 31326 Glu Met His Pro Ser Trp Ile Met Ile Val Gly Ile Val Asn Ile 5825 5830 5835 ctt gcc tgt acc ctc ttc tcc ttt gtg att tac ccc cgc ttt gac 31371 Leu Ala Cys Thr Leu Phe Ser Phe Val Ile Tyr Pro Arg Phe Asp 5840 5845 5850 ttt ggg tgg aac gca ccc gag gcg ctc tgg ctc ccg cct gat ccc 31416 Phe Gly Trp Asn Ala Pro Glu Ala Leu Trp Leu Pro Pro Asp Pro 5855 5860 5865 gac aca cca cca cag cag cag caa aat cag gca cag gca cat gca 31461 Asp Thr Pro Pro Gln Gln Gln Gln Asn Gln Ala Gln Ala His Ala 5870 5875 5880 cca cca cag cct agg cca caa tac atg ccc atc tta gac tat gag 31506 Pro Pro Gln Pro Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu 5885 5890 5895 gcc gag cca cag cga gcc atg ctt cct gct att agt tac ttc aat 31551 Ala Glu Pro Gln Arg Ala Met Leu Pro Ala Ile Ser Tyr Phe Asn 5900 5905 5910 cta acc ggc gga gat gac tgaccccatg gccaacaaca ccgtcaacga 31599 Leu Thr Gly Gly Asp Asp 5915 5920 cctcctggac atggacggcc gcgcctcgga gcagcgactc gcccaactcc gcatccgcca 31659 gcagcaggag agagccgtca aggagctgca ggacgcggtg gccatccacc agtgcaagag 31719 aggcatcttc tgcctggtga agcaggccaa gatctccttc gaggtcacgt ccaccgacca 31779 tcgcctctcc tacgagctcc tgcagcagcg ccagaagttc acctgcctgg tcggagtcaa 31839 ccccatcgtc atcacccagc agtctggcga taccaagggt tgcatccact gctcctgcga 31899 ctcccccgag tgcgttcaca ccctgatcaa gaccctctgc ggcctccgcg acctcctccc 31959 catgaactaa tcaactaacc ccctacccct ttaccctcca gtaaaaataa agattaaaaa 32019 tgattgaatt gatcaataaa gaatcactta cttgaaatct gaaaccaggt ctctgtcc 32077 atg ttt tct gtc agc agc act tca ctc ccc tct tcc caa ctc tgg 32122 Met Phe Ser Val Ser Ser Thr Ser Leu Pro Ser Ser Gln Leu Trp 5925 5930 5935 tac tgc agg ccc cgg cgg gct gca aac ttc ctc cac act ctg aag 32167 Tyr Cys Arg Pro Arg Arg Ala Ala Asn Phe Leu His Thr Leu Lys 5940 5945 5950 ggg atg tca aat tcc tcc tgt ccc tca atc ttc att ttt atc ttc 32212 Gly Met Ser Asn Ser Ser Cys Pro Ser Ile Phe Ile Phe Ile Phe 5955 5960 5965 tat cag atg tcc aaa aag cgc gcg cgg gtg gat gat ggc ttc gac 32257 Tyr Gln Met Ser Lys Lys Arg Ala Arg Val Asp Asp Gly Phe Asp 5970 5975 5980 ccc gtg tac ccc tac gat gca gac aac gca ccg act gtg ccc ttc 32302 Pro Val Tyr Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe 5985 5990 5995 atc aac cct ccc ttc gtc tct tca gat gga ttc caa gaa aag ccc 32347 Ile Asn Pro Pro Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro 6000 6005 6010 ctg ggg gtg ttg tcc ctg cga ctg gcc gac ccc gtc acc acc aag 32392 Leu Gly Val Leu Ser Leu Arg Leu Ala Asp Pro Val Thr Thr Lys 6015 6020 6025 aat ggg gct gtc acc ctc aag ctg ggg gag ggg gtg gac ctc gac 32437 Asn Gly Ala Val Thr Leu Lys Leu Gly Glu Gly Val Asp Leu Asp 6030 6035 6040 gac tcg gga aaa ctc atc tcc aaa aat gcc acc aag gcc act gcc 32482 Asp Ser Gly Lys Leu Ile Ser Lys Asn Ala Thr Lys Ala Thr Ala 6045 6050 6055 cct ctc agt att tcc aac ggc acc att tcc ctt aac atg gcc gcc 32527 Pro Leu Ser Ile Ser Asn Gly Thr Ile Ser Leu Asn Met Ala Ala 6060 6065 6070 cct ttt tac aac aac aat gga acg tta agt ctc aat gtt tct aca 32572 Pro Phe Tyr Asn Asn Asn Gly Thr Leu Ser Leu Asn Val Ser Thr 6075 6080 6085 cca tta gca gta ttt ccc act ttt aac act tta ggt atc agt ctt 32617 Pro Leu Ala Val Phe Pro Thr Phe Asn Thr Leu Gly Ile Ser Leu 6090 6095 6100 gga aac ggt ctt caa act tct aat aag ttg ctg act gta cag tta 32662 Gly Asn Gly Leu Gln Thr Ser Asn Lys Leu Leu Thr Val Gln Leu 6105 6110 6115 act cat cct ctt aca ttc agc tca aat agc atc aca gta aaa aca 32707 Thr His Pro Leu Thr Phe Ser Ser Asn Ser Ile Thr Val Lys Thr 6120 6125 6130 gac aaa gga ctc tat att aat tct agt gga aac aga ggg ctt gag 32752 Asp Lys Gly Leu Tyr Ile Asn Ser Ser Gly Asn Arg Gly Leu Glu 6135 6140 6145 gct aac ata agc cta aaa aga gga ctg att ttt gat ggt aat gct 32797 Ala Asn Ile Ser Leu Lys Arg Gly Leu Ile Phe Asp Gly Asn Ala 6150 6155 6160 att gca aca tac ctt gga agt ggt tta gac tat gga tcc tat gat 32842 Ile Ala Thr Tyr Leu Gly Ser Gly Leu Asp Tyr Gly Ser Tyr Asp 6165 6170 6175 agc gat ggg aaa aca aga ccc atc atc acc aaa att gga gca ggt 32887 Ser Asp Gly Lys Thr Arg Pro Ile Ile Thr Lys Ile Gly Ala Gly 6180 6185 6190 ttg aat ttt gat gct aat aat gcc atg gct gtg aag cta ggc aca 32932 Leu Asn Phe Asp Ala Asn Asn Ala Met Ala Val Lys Leu Gly Thr 6195 6200 6205 ggt tta agt ttt gac tct gcc ggt gcc tta aca gct gga aac aaa 32977 Gly Leu Ser Phe Asp Ser Ala Gly Ala Leu Thr Ala Gly Asn Lys 6210 6215 6220 gag gat gac aag cta aca ctt tgg act aca cct gac cca agc cct 33022 Glu Asp Asp Lys Leu Thr Leu Trp Thr Thr Pro Asp Pro Ser Pro 6225 6230 6235 aat tgt caa tta ctt tca gac aga gat gcc aaa ttt acc cta tgt 33067 Asn Cys Gln Leu Leu Ser Asp Arg Asp Ala Lys Phe Thr Leu Cys 6240 6245 6250 ctt aca aaa tgc ggt agt caa ata cta ggc act gtt gca gta gct 33112 Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Ala Val Ala 6255 6260 6265 gct gtt act gta ggt tca gca cta aat cca att aat gac aca gta 33157 Ala Val Thr Val Gly Ser Ala Leu Asn Pro Ile Asn Asp Thr Val 6270 6275 6280 aaa agc gcc ata gta ttc ctt aga ttt gac tct gac ggt gtg ctc 33202 Lys Ser Ala Ile Val Phe Leu Arg Phe Asp Ser Asp Gly Val Leu 6285 6290 6295 atg tca aac tca tca atg gta ggt gat tac tgg aac ttt agg gaa 33247 Met Ser Asn Ser Ser Met Val Gly Asp Tyr Trp Asn Phe Arg Glu 6300 6305 6310 gga cag acc acc caa agt gtg gcc tat aca aat gct gtg gga ttc 33292 Gly Gln Thr Thr Gln Ser Val Ala Tyr Thr Asn Ala Val Gly Phe 6315 6320 6325 atg ccc aat cta ggt gca tat cct aaa acc caa agc aaa aca cca 33337 Met Pro Asn Leu Gly Ala Tyr Pro Lys Thr Gln Ser Lys Thr Pro 6330 6335 6340 aaa aat agt ata gta agt cag gta tat tta aat gga gaa act act 33382 Lys Asn Ser Ile Val Ser Gln Val Tyr Leu Asn Gly Glu Thr Thr 6345 6350 6355 atg cca atg aca ctg aca ata act ttc aat ggc act gat gaa aaa 33427 Met Pro Met Thr Leu Thr Ile Thr Phe Asn Gly Thr Asp Glu Lys 6360 6365 6370 gac aca aca cct gtg agc act tac tcc atg act ttt aca tgg cag 33472 Asp Thr Thr Pro Val Ser Thr Tyr Ser Met Thr Phe Thr Trp Gln 6375 6380 6385 tgg act gga gac tat aag gac aag aat att acc ttt gct acc aac 33517 Trp Thr Gly Asp Tyr Lys Asp Lys Asn Ile Thr Phe Ala Thr Asn 6390 6395 6400 tcc ttt act ttc tcc tac atg gcc caa gaa taaaccctgc atgccaaccc 33567 Ser Phe Thr Phe Ser Tyr Met Ala Gln Glu 6405 6410 cattgttccc accactatgg aaaactctga agcagaaaaa aataaagttc aagtgtttta 33627 ttgattcaac agttttcaca gaattcgagt agttattttc cctcctccct cccaactcat 33687 ggaatacacc accctctccc cacgcacagc cttaaacatc tgaatgccat tggtaatgga 33747 catggttttg gtctccacat tccacacagt ttcagagcga gccagtctcg ggtcggtcag 33807 ggagatgaaa ccctccgggc actcctgcat ctgcacctca aagttcagta gctgagggct 33867 gtcctcggtg gtcgggatca cagttatctg gaagaagagc ggtgagagtc ataatccgcg 33927 aacgggatcg ggcggttgtg gcgcatcagg ccccgcagca gtcgctgtct gcgccgctcc 33987 gtcaagctgc tgctcaaggg gtctgggtcc agggactccc tgcgcatgat gccgatggcc 34047 ctgagcatca gtcgcctggt gcggcgggcg cagcagcgga tgcggatctc actcaggtcg 34107 gagcagtacg tgcagcacag cactaccaag ttgttcaaca gtccatagtt caacgtgctc 34167 cagccaaaac tcatctgtgg aactatgctg cccacatgtc catcgtacca gatcctgatg 34227 taaatcaggt ggcgccccct ccagaacaca ctgcccatgt acatgatctc cttgggcatg 34287 tgcaggttca ccacctcccg gtaccacatc acccgctggt tgaacatgca gccctggata 34347 atcctgcgga accagatggc cagcaccgcc ccgcccgcca tgcagcgcag ggaccccggg 34407 tcctggcaat ggcagtggag cacccaccgc tcacggccgt ggattaactg ggagctgaac 34467 aagtctatgt tggcacagca caggcacacg ctcatgcatg tcttcagcac tctcagttcc 34527 tcgggggtca ggaccatgtc ccagggcacg gggaactctt gcaggacagt gaacccggca 34587 gaacagggca gccctcgcac acaacttaca ttgtgcatgg acagggtatc gcaatcaggc 34647 agcaccggat gatcctccac cagagaagcg cgggtctcgg tctcctcaca gcgaggtaag 34707 ggggccggcg gttggtacgg atgatggcgg gatgacgcta atcgtgttct ggatcgtgtc 34767 atgatggagc tgtttcctga cattttcgta cttcacgaag cagaacctgg tacgggcact 34827 gcacaccgct cgccggcgac ggtctcggcg cttcgagcgc tcggtgttga agttatagaa 34887 cagccactcc ctcagagcgt gcagtatctc ctgagcctct tgggtgatga aaatcccatc 34947 cgctctgatg gctctgatca catcggccac ggtggaatgg gccagaccca gccagatgat 35007 gcaattttgt tgggtttcgg tgacggaggg agagggaaga acaggaagaa ccatgattaa 35067 ctttattcca aacggtctcg gagcacttca aaatgcaggt cccggaggtg gcacctctcg 35127 cccccactgt gttggtggaa aataacagcc aggtcaaagg tgacacggtt ctcgagatgt 35187 tccacggtgg cttccagcaa agcctccacg cgcacatcca gaaacaagag gacagcgaaa 35247 gcgggagcgt tttctaattc ctcaatcatc atattacact cctgcaccat ccccagataa 35307 ttttcatttt tccagccttg aatgattcgt attagttcct gaggtaaatc caagccagcc 35367 atgataaaaa gctcgcgcag agcgccctcc accggcattc ttaagcacac cctcataatt 35427 ccaagagatt ctgctcctgg ttcacctgca gcagattaac aatgggaata tcaaaatctc 35487 tgccgcgatc cctaagctcc tccctcaaca ataactgtat gtaatctttc atatcatctc 35547 cgaaattttt agccataggg ccgccaggaa taagagcagg gcaagccaca ttacagataa 35607 agcgaagtcc tccccagtga gcattgccaa atgtaagatt gaaataagca tgctggctag 35667 accctgtgat atcttccaga taactggaca gaaaatcagg caagcaattt ttaagaaaat 35727 caacaaaaga aaagtcgtcc aggtgcaggt ttagagcctc aggaacaacg atggaataag 35787 tgcaaggagt gcgttccagc atggttagtg tttttttggt gatctgtaga acaaaaaata 35847 aacatgcaat attaaaccat gctagcctgg cgaacaggtg ggtaaatcac tctttccagc 35907 accaggcagg ctacggggtc tccggcgcga ccctcgtaga agctgtcgcc atgattgaaa 35967 agcatcaccg agagaccttc ccggtggccg gcatggatga ttcgagaaga agcatacact 36027 ccgggaacat tggcatccgt gagtgaaaaa aagcgaccta taaagcctcg gggcactaca 36087 atgctcaatc tcaattccag caaagccacc ccatgcggat ggagcacaaa attggcaggt 36147 gcgtaaaaaa tgtaattact cccctcctgc acaggcagca aagcccccgc tccctccaga 36207 aacacataca aagcctcagc gtccatagct taccgagcac ggcaggcgca agagtcagag 36267 aaaaggctga gctctaacct gactgcccgc tcctgtgctc aatatatagc cctaacctac 36327 actgacgtaa aggccaaagt ctaaaaatac ccgccaaaat gacacacacg cccagcacac 36387 gcccagaaac cggtgacaca ctcaaaaaaa tacgtgcgct tcctcaaacg cccaaaccgg 36447 cgtcatttcc gggttcccac gctacgtcac cgctcagcga ctttcaaatt ccgtcgaccg 36507 ttaaaaacgt cactcgcccc gcccctaacg gtcgcccttc tctcggccaa tcaccttcct 36567 cccttcccaa attcaaacgc ctcatttgca tattaacgcg cacaaaaagt ttgaggtata 36627 ttattgatga tg 36639 <210> 78 <211> 188 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 78 Met Glu Ile Trp Thr Val Leu Glu Asp Phe His Lys Thr Arg Gln Leu 1 5 10 15 Leu Glu Asn Ala Ser Asn Gly Val Ser Tyr Leu Trp Arg Phe Cys Phe 20 25 30 Gly Gly Asp Leu Ala Arg Leu Val Tyr Arg Ala Lys Gln Asp Tyr Ser 35 40 45 Glu Gln Phe Glu Val Ile Leu Arg Glu Cys Pro Gly Leu Phe Asp Ala 50 55 60 Leu Asn Leu Gly His Gln Ser His Phe Asn Gln Arg Ile Ser Arg Ala 65 70 75 80 Leu Asp Phe Thr Thr Pro Gly Arg Thr Thr Ala Ala Val Ala Phe Phe 85 90 95 Ala Phe Ile Leu Asp Lys Trp Ser Gln Glu Thr His Phe Ser Arg Asp 100 105 110 Tyr Gln Leu Asp Phe Leu Ala Val Ala Leu Trp Arg Thr Trp Lys Cys 115 120 125 Gln Arg Leu Asn Ala Ile Ser Gly Tyr Leu Pro Val Gln Pro Leu Asp 130 135 140 Thr Leu Arg Ile Leu Asn Leu Gln Glu Ser Pro Arg Ala Arg Gln Arg 145 150 155 160 Arg Gln Gln Gln Gln Arg Gln Gln Glu Glu Asp Gln Glu Glu Asn Pro 165 170 175 Arg Ala Gly Leu Asp Pro Pro Glu Glu Glu Glu Glu 180 185 <210> 79 <211> 394 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 79 Met His Pro Val Leu Arg Gln Met Arg Pro His His Pro Pro Pro Gln 1 5 10 15 Gln Gln Pro Pro Pro Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln 20 25 30 Gln Gln Leu Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala Gly 35 40 45 Gln Thr Ser Gln Tyr Asp Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala 50 55 60 Arg Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys 65 70 75 80 Arg Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp 85 90 95 Arg Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ala Arg Phe His Ala 100 105 110 Gly Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp 115 120 125 Glu Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala 130 135 140 His Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys 145 150 155 160 Glu Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu 165 170 175 Ile Ala Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu 180 185 190 Leu Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln 195 200 205 Leu Phe Leu Val Val Gln His Ser Arg Asp Asn Glu Ala Phe Arg Glu 210 215 220 Ala Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu 225 230 235 240 Val Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu 245 250 255 Ser Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys 260 265 270 Tyr Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys 275 280 285 Glu Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu 290 295 300 Thr Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg 305 310 315 320 Ala Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met 325 330 335 His Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser 340 345 350 Tyr Phe Asp Met Gly Ala Asp Leu His Trp Gln Pro Ser Arg Arg Ala 355 360 365 Leu Glu Ala Ala Gly Gly Pro Pro Tyr Ile Glu Glu Val Asp Asp Glu 370 375 380 Val Asp Glu Glu Gly Glu Tyr Leu Glu Asp 385 390 <210> 80 <211> 589 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 80 Met Gln Gln Gln Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu Gln 1 5 10 15 Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala Met 20 25 30 Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg Gln 35 40 45 Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val Pro 50 55 60 Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn Ala 65 70 75 80 Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val Tyr 85 90 95 Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val Gln 100 105 110 Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ala Gln 115 120 125 Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala Leu 130 135 140 Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln Glu 145 150 155 160 Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Thr Glu Val 165 170 175 Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr 180 185 190 Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys Asn 195 200 205 Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala Thr 210 215 220 Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu Val 225 230 235 240 Ala Pro Phe Thr Asp Ser Gly Ser Ile Asn Arg Asn Ser Tyr Leu Gly 245 250 255 Tyr Leu Ile Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp 260 265 270 Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly Gln 275 280 285 Asp Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr Asn 290 295 300 Arg Ser Gln Lys Ile Pro Pro Gln Tyr Thr Leu Ser Ala Glu Glu Glu 305 310 315 320 Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met Gln 325 330 335 Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn Met 340 345 350 Glu Pro Ser Met Tyr Ala Ser Asn Arg Pro Phe Ile Asn Lys Leu Met 355 360 365 Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr Asn 370 375 380 Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr Gly 385 390 395 400 Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp Val 405 410 415 Asp Ser Ser Val Phe Ser Pro Arg Pro Gly Ala Asn Glu Arg Pro Leu 420 425 430 Trp Lys Lys Glu Gly Ser Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly 435 440 445 Arg Glu Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro 450 455 460 Ser Leu Pro Phe Ser Leu Asn Ser Ile Arg Ser Ser Glu Leu Gly Arg 465 470 475 480 Ile Thr Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser 485 490 495 Leu Leu Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu 500 505 510 Ser Leu Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala Gln Glu His 515 520 525 Arg Asp Asp Pro Ser Gln Gly Ala Thr Ser Arg Gly Ser Ala Ala Arg 530 535 540 Lys Arg Arg Trp His Asp Arg Gln Arg Gly Leu Met Trp Asp Asp Glu 545 550 555 560 Asp Ser Ala Asp Asp Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Asn 565 570 575 Pro Phe Ala His Leu Arg Pro Arg Ile Gly Arg Met Met 580 585 <210> 81 <211> 532 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 81 Met Met Arg Arg Ala Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Met Ala Ala Ala Ala Ala Met Gln Pro Pro Leu 20 25 30 Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg 35 40 45 Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg 50 55 60 Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr 65 70 75 80 Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp 85 90 95 Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg 100 105 110 Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro 115 120 125 Asn Val Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met 130 135 140 Val Ser Arg Lys Thr Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln 145 150 155 160 Asp Ile Leu Glu Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn 165 170 175 Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp 180 185 190 Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile 195 200 205 Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val 210 215 220 Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro 225 230 235 240 Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg 245 250 255 Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly 260 265 270 Phe Gln Ile Met Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu 275 280 285 Leu Asp Val Asp Ala Tyr Glu Lys Ser Lys Glu Glu Ser Ala Ala Ala 290 295 300 Ala Thr Ala Ala Val Ala Thr Ala Ser Thr Glu Val Arg Gly Asp Asn 305 310 315 320 Phe Ala Ser Pro Ala Ala Val Ala Ala Ala Glu Ala Ala Glu Thr Glu 325 330 335 Ser Lys Ile Val Ile Gln Pro Val Glu Lys Asp Ser Lys Asp Arg Ser 340 345 350 Tyr Asn Val Leu Pro Asp Lys Ile Asn Thr Ala Tyr Arg Ser Trp Tyr 355 360 365 Leu Ala Tyr Asn Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr 370 375 380 Leu Leu Thr Thr Ser Asp Val Thr Cys Gly Val Glu Gln Val Tyr Trp 385 390 395 400 Ser Leu Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg 405 410 415 Gln Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val Tyr 420 425 430 Ser Lys Ser Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg 435 440 445 Ala Phe Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln 450 455 460 Ile Leu Val Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn 465 470 475 480 Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile 485 490 495 Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys 500 505 510 Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val Ala Pro Arg Val Leu Ser 515 520 525 Ser Arg Thr Phe 530 <210> 82 <211> 193 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 82 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Val Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ala 130 135 140 Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala Ala 145 150 155 160 Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val Arg 165 170 175 Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro Arg 180 185 190 Thr <210> 83 <211> 342 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 83 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Val Val Lys Glu Glu Arg Lys Pro Arg Lys 20 25 30 Ile Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Glu Ser Asp Val Asp 35 40 45 Gly Leu Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln 50 55 60 Trp Arg Gly Arg Lys Val Arg Pro Val Leu Arg Pro Gly Thr Thr Val 65 70 75 80 Val Phe Thr Pro Gly Glu Arg Ser Gly Thr Ala Ser Lys Arg Ser Tyr 85 90 95 Asp Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Ala Glu Arg 100 105 110 Leu Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Ser Ala Pro Lys Glu 115 120 125 Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu 130 135 140 Lys Pro Val Thr Leu Gln Gln Val Leu Pro Thr Ala Ala Pro Arg Arg 145 150 155 160 Gly Phe Lys Arg Glu Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met 165 170 175 Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu Thr Met Lys Val 180 185 190 Asp Pro Asp Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln Val 195 200 205 Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr Glu 210 215 220 Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr Met 225 230 235 240 Glu Val Gln Thr Asp Pro Trp Met Pro Ser Ala Thr Ser Arg Arg Pro 245 250 255 Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn Tyr Ala Leu 260 265 270 His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg Phe Tyr 275 280 285 Arg Gly His Thr Ser Arg Arg Arg Lys Thr Thr Thr Arg Arg Arg Arg 290 295 300 Arg Arg Thr Thr Ala Ala Ala Ser Thr Pro Ala Ala Leu Val Arg Arg 305 310 315 320 Val Tyr Arg Arg Gly Arg Ala Pro Leu Thr Leu Pro Arg Ala Arg Tyr 325 330 335 His Pro Ser Ile Ala Ile 340 <210> 84 <211> 77 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 84 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Ala Gly Asn Gly Met Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 85 <211> 259 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 85 Met Asp Ser Asp Ala Pro Gly Pro Val Met Cys Phe Arg Arg Gln Met 1 5 10 15 Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg Pro 20 25 30 Phe Met Gly Thr Trp Ser Asp Ile Gly Thr Ser Gln Leu Asn Gly Gly 35 40 45 Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser 50 55 60 Thr Leu Lys Thr Tyr Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly Gln 65 70 75 80 Ala Leu Arg Asp Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val Val 85 90 95 Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn Gln 100 105 110 Ala Val Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro Ala 115 120 125 Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu Asp 130 135 140 Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu Leu 145 150 155 160 Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu Gly 165 170 175 Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu Lys 180 185 190 Pro Glu Ser Ser Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Gln Pro 195 200 205 Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val Ala 210 215 220 Arg Ala Arg Pro Gly Gly Thr Ala Arg Pro His Ala Asn Trp Gln Ser 225 230 235 240 Thr Leu Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg Arg 245 250 255 Arg Cys Tyr <210> 86 <211> 931 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 86 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Thr Cys Gln Trp Thr Tyr Thr Asp Lys Gln Thr Glu Lys 130 135 140 Thr Ala Thr Tyr Gly Asn Ala Pro Val Gln Gly Ile Ala Ile Thr Lys 145 150 155 160 Asp Gly Ile Gln Leu Gly Thr Asp Ser Asp Gly Asn Pro Val Tyr Ala 165 170 175 Gln Lys Thr Phe Glu Pro Glu Pro Gln Val Gly Asp Ala Glu Trp His 180 185 190 Asp Thr Thr Gly Thr Asp Glu Lys Tyr Gly Gly Arg Ala Leu Lys Pro 195 200 205 Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys Pro Thr Asn 210 215 220 Lys Glu Gly Gly Gln Ala Lys Asn Arg Thr Lys Thr Asp Gly Thr Gly 225 230 235 240 Glu Glu Pro Asp Ile Asp Met Ala Phe Phe Asp Gly Arg Asn Ala Thr 245 250 255 Thr Ala Gly Leu Ala Pro Glu Ile Val Leu Tyr Thr Glu Asn Val Asp 260 265 270 Leu Glu Thr Pro Asp Thr His Ile Val Tyr Lys Ala Gly Thr Asp Asp 275 280 285 Ser Ser Ser Ser Ile Asn Leu Gly Gln Gln Ser Met Pro Asn Arg Pro 290 295 300 Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn 305 310 315 320 Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn 325 330 335 Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu 340 345 350 Leu Leu Asp Ser Leu Gly Asp Arg Thr Leu Tyr Phe Ser Met Trp Asn 355 360 365 Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His 370 375 380 Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asp Ala Val 385 390 395 400 Gly Arg Thr Asp Thr Tyr Gln Gly Ile Lys Pro Asn Gly Gly Asp Pro 405 410 415 Ala Thr Trp Ala Lys Asp Asp Ser Ala Asn Asp Ala Asn Glu Met Gly 420 425 430 Lys Gly Asn Pro Phe Ala Met Glu Ile Asn Ile Gln Ala Asn Leu Trp 435 440 445 Arg Asn Phe Leu Tyr Ala Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr 450 455 460 Lys Tyr Thr Pro Ala Asn Val Thr Leu Pro Thr Asn Thr Asn Thr Tyr 465 470 475 480 Asp Tyr Met Asn Gly Arg Val Val Ala Pro Ser Leu Val Asp Ser Tyr 485 490 495 Ile Asn Ile Gly Ala Arg Trp Ser Leu Asp Pro Met Asp Asn Val Asn 500 505 510 Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu 515 520 525 Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro Gln Lys 530 535 540 Phe Phe Ala Ile Lys Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr 545 550 555 560 Glu Trp Asn Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu 565 570 575 Gly Asn Asp Leu Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile 580 585 590 Asn Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr 595 600 605 Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp 610 615 620 Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr 625 630 635 640 Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly 645 650 655 Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser 660 665 670 Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp 675 680 685 Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe 690 695 700 Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn 705 710 715 720 Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn Val Ala 725 730 735 Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala His 740 745 750 Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys Asp 755 760 765 Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val 770 775 780 Val Asp Glu Val Asn Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr 785 790 795 800 Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg 805 810 815 Gln Gly Gln Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys 820 825 830 Ser Ala Val Thr Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val 835 840 845 Met Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu 850 855 860 Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu 865 870 875 880 Asp Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr 885 890 895 Val Val Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro His Arg 900 905 910 Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn 915 920 925 Ala Thr Thr 930 <210> 87 <211> 210 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 87 Met Met Ala Glu Ala Ala Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile 1 5 10 15 Ile Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys 20 25 30 Arg Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val 35 40 45 Asn Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala 50 55 60 Trp Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe 65 70 75 80 Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu 85 90 95 Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu 100 105 110 Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu 115 120 125 Phe Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro 130 135 140 Met Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly 145 150 155 160 Met Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu 165 170 175 Ala Leu Tyr Arg Phe Leu Asn Ser His Ser Ala Tyr Phe Arg Ser His 180 185 190 Arg Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Asn Gln 195 200 205 Asp Met 210 <210> 88 <211> 801 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 88 Met Glu Thr Gln Pro Ser Pro Thr Ser Pro Ser Ala Pro Thr Thr Ala 1 5 10 15 Asp Glu Lys Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro Pro Ser Pro 20 25 30 Ala Thr Ser Asp Ala Ala Ala Val Pro Asp Met Gln Glu Met Glu Glu 35 40 45 Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu Glu 50 55 60 Glu Leu Ala Val Arg Phe Gln Ser Ser Ser Gln Glu Asp Lys Glu Gln 65 70 75 80 Pro Glu Gln Glu Ala Glu Asn Glu Gln Ser Gln Ala Gly Leu Glu His 85 90 95 Asp Gly Asp Tyr Leu His Leu Ser Gly Glu Glu Asp Ala Leu Ile Lys 100 105 110 His Leu Ala Arg Gln Ala Ile Ile Val Lys Asp Ala Leu Leu Asp Arg 115 120 125 Thr Glu Val Pro Leu Ser Val Glu Glu Leu Ser Arg Ala Tyr Glu Leu 130 135 140 Asn Leu Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr 145 150 155 160 Cys Glu Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro 165 170 175 Glu Ala Leu Ala Thr Tyr His Ile Phe Phe Lys Asn Gln Lys Ile Pro 180 185 190 Val Ser Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Phe Asn Leu 195 200 205 Gly Pro Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro 210 215 220 Lys Ile Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala 225 230 235 240 Leu Gln Gly Glu Gly Gly Glu His Glu His His Ser Ala Leu Val Glu 245 250 255 Leu Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu 260 265 270 Leu Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met 275 280 285 Ser Ala Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Ile Ser 290 295 300 Glu Asp Glu Gly Met Gln Asp Ser Glu Asp Gly Lys Pro Val Val Ser 305 310 315 320 Asp Glu Gln Leu Ala Arg Trp Leu Gly Pro Asn Ala Ser Pro Gln Ser 325 330 335 Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr Val 340 345 350 Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu Arg 355 360 365 Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val Arg 370 375 380 Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr 385 390 395 400 Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr 405 410 415 Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr 420 425 430 Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln Gln 435 440 445 Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys 450 455 460 Asn Leu Lys Gly Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser 465 470 475 480 Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg 485 490 495 Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg 500 505 510 Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala 515 520 525 Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro 530 535 540 Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala Tyr 545 550 555 560 His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu Cys 565 570 575 His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys Asn 580 585 590 Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln 595 600 605 Gly Pro Ser Asp Asp Gly Glu Gly Ala Lys Gly Gly Leu Lys Leu Thr 610 615 620 Pro Gly Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp 625 630 635 640 Tyr His Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro 645 650 655 Lys Ala Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala 660 665 670 Gln Leu Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys 675 680 685 Gly Arg Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro 690 695 700 Gly Phe Pro Gln Asp Ala Pro Arg Lys Gln Glu Ala Glu Ser Gly Ala 705 710 715 720 Ala Ala Arg Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Gln Ser Gly 725 730 735 Arg Gly Gly Asp Gly Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly 740 745 750 Gln Pro Ala Arg Gln Ser Gly Gly Arg Arg Gly Gly Gly Arg Gly Gly 755 760 765 Arg Ser Ser Arg Arg Gln Thr Val Val Leu Gly Gly Gly Glu Ser Lys 770 775 780 Gln His Gly Tyr His Leu Arg Ser Gly Ser Gly Ser Arg Ser Ala Pro 785 790 795 800 Gln <210> 89 <211> 227 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 89 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Leu Thr Ala Thr 50 55 60 Pro Arg Asn His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Thr Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Ile Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 90 <211> 106 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 90 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Thr 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Val Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Gln Gln Gly Asn Thr Leu Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asp His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 91 <211> 176 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 91 Met Gly Lys Ile Thr Leu Val Cys Gly Val Leu Val Thr Val Val Leu 1 5 10 15 Ser Ile Leu Gly Gly Gly Ser Ala Ala Val Val Thr Glu Lys Lys Ala 20 25 30 Asp Pro Cys Leu Thr Phe Asn Pro Asp Lys Cys Arg Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Thr Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Ser Val Ala Ile Gln Tyr Lys Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Thr Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Leu His Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Glu His Met Cys Glu Thr Ala Met Phe Met Ser Lys Gln Tyr Gly Met 115 120 125 Trp Pro Pro Arg Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Ala Cys Thr Val Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 92 <211> 247 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 92 Met Arg Leu Leu Ile Phe Val Ile Ile Thr Leu Ser Phe Asn Tyr Ala 1 5 10 15 His Gly Tyr Ala Asn Ile Gln Lys Thr Leu Tyr Val Gly Ser Asp Ser 20 25 30 Thr Leu Glu Gly Thr Gln Ser Gln Ala Arg Val Ser Trp Tyr Phe Tyr 35 40 45 Lys Gly Ser Asp Asp Pro Ile Thr Leu Cys Lys Gly Asp Gln Gly Arg 50 55 60 Ile Thr Lys Pro Pro Ile Thr Phe Ser Cys Thr Arg Thr Asn Leu Thr 65 70 75 80 Leu Leu Ser Ile Thr Lys Glu Tyr Ala Gly Thr Tyr Tyr Ser Thr Asn 85 90 95 Phe His Arg Gly Gln Asp Lys Tyr Tyr Thr Val Lys Val Glu Asn Pro 100 105 110 Thr Thr Pro Arg Thr Thr Thr Lys Pro Thr Thr Thr Lys Lys Pro Thr 115 120 125 Thr Pro Lys Lys Pro Thr Thr Pro Lys Thr Thr Lys Thr Thr Thr Ala 130 135 140 Lys Thr Thr Thr Thr Lys Pro Thr Thr Thr Ser Thr Thr Leu Ala Ile 145 150 155 160 Thr Thr His Thr His Thr Glu Leu Thr Ser Gln Ala Thr Thr Glu Asn 165 170 175 Asp Leu Val Ala Leu Leu Gln Lys Gly Glu Asn Ser Ser Ser Ser Pro 180 185 190 Leu Pro Thr Thr Pro Ser Glu Glu Ile Pro Lys Ser Met Val Gly Ile 195 200 205 Ile Ala Ala Val Val Val Cys Met Leu Ile Ile Ile Leu Cys Met Met 210 215 220 Tyr Tyr Ala Cys Tyr Tyr Arg Lys His Arg Leu Asn Asn Lys Leu Asp 225 230 235 240 Pro Leu Leu Ser Val Asp Phe 245 <210> 93 <211> 208 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 93 Met Lys Ile Leu Ser Leu Phe Val Phe Ser Ile Ile Ile Thr Ser Ala 1 5 10 15 Ile Cys Glu Ser Val Asp Lys Asp Val Thr Val Thr Thr Gly Ser Asn 20 25 30 Tyr Thr Leu Lys Gly Pro Ser Ser Gly Met Leu Ser Trp Tyr Cys Tyr 35 40 45 Phe Gly Asn Asp Asp Lys Gln Thr Glu Leu Cys Asn Phe Gln Asn Gly 50 55 60 Lys Thr Lys Asn Ser Lys Ile Asp Asn Tyr Gln Cys Gln Gly Thr Asn 65 70 75 80 Leu Val Leu Met Asn Ile Thr Lys Ala Tyr Ala Gly Ser Tyr Ser Cys 85 90 95 Pro Gly Gln Asn Thr Glu Glu Met Ile Phe Tyr Lys Leu Ile Val Val 100 105 110 Asp Pro Thr Thr Pro Ala Pro Pro Thr Thr Thr Lys Ala His Thr Thr 115 120 125 Asp Thr Gln Glu Thr Thr Pro Glu Ala Glu Val Ala Glu Leu Ala Lys 130 135 140 Gln Ile His Glu Asp Ser Phe Val Ala Asn Thr Pro Thr His Pro Gly 145 150 155 160 Pro Gln Cys Pro Gly Pro Leu Val Ser Gly Ile Val Gly Val Leu Cys 165 170 175 Gly Leu Ala Val Ile Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr 180 185 190 Arg Arg Leu His Arg Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 195 200 205 <210> 94 <211> 291 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 94 Met Lys Ala Leu Ser Thr Leu Val Phe Leu Ser Leu Ile Gly Ile Val 1 5 10 15 Phe Ser Ala Gly Phe Leu Lys Asn Leu Thr Ile Ile Glu Gly Asp Asn 20 25 30 Ala Thr Leu Val Gly Ile Ser Gly Gln Asn Val Ser Trp Leu Lys Tyr 35 40 45 His Leu Asp Gly Trp Lys Pro Ile Cys Thr Trp Asn Val Ser Val Tyr 50 55 60 Thr Cys His Gly Val Asn Leu Thr Ile Thr Asn Ala Thr Gln Asp Gln 65 70 75 80 Asn Gly Arg Phe Lys Gly Gln Ser Phe Thr Ser Asn Asn Gly Tyr Glu 85 90 95 Thr His Asn Met Phe Ile Tyr Asp Val Thr Val Ile Ser Asn Lys Thr 100 105 110 Thr Pro Thr Thr Gln Thr Pro Thr Thr His Ser Ser Thr His Ala Met 115 120 125 Gln Thr Thr Gln Thr Thr Thr Tyr Thr Thr Ser Thr Glu Ser Thr Thr 130 135 140 Thr Thr Thr Ala Glu Val Ser Ser Thr Ala Pro Gln Pro Gln Ala Leu 145 150 155 160 Ala Leu Met Ala Gln Pro Ser Ser Met Thr Ala Lys Thr Asn Glu Gln 165 170 175 Thr Thr Glu Phe Leu Ser Thr Ile Gln Ser Ser Thr Thr Ala Thr Ser 180 185 190 Ser Ala Phe Ser Ser Thr Ala Asn Leu Thr Ser Leu Ser Ser Thr Pro 195 200 205 Ile Ser Asn Ala Thr Thr Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys 210 215 220 Gln Ser Glu Ser Ser Thr Gln Leu Gln Ile Thr Leu Leu Ile Val Ile 225 230 235 240 Gly Val Val Ile Leu Ala Val Leu Leu Tyr Phe Ile Phe Cys Arg Arg 245 250 255 Ile Pro Asn Ala Lys Pro Ala Tyr Lys Pro Ile Val Ile Gly Thr Pro 260 265 270 Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser Phe 275 280 285 Thr Val Trp 290 <210> 95 <211> 149 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 95 Met Ile Ser Met Arg Ala Leu Leu Leu Leu Leu Ala Leu Leu Leu Ala 1 5 10 15 Pro Leu Ala Ala Pro Leu Ser Leu Lys Ser Pro Thr Gln Ser Pro Glu 20 25 30 Glu Val Arg Lys Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Ser Cys 35 40 45 Tyr Lys Leu Lys Ser Glu Met His Pro Ser Trp Ile Met Ile Val Gly 50 55 60 Ile Val Asn Ile Leu Ala Cys Thr Leu Phe Ser Phe Val Ile Tyr Pro 65 70 75 80 Arg Phe Asp Phe Gly Trp Asn Ala Pro Glu Ala Leu Trp Leu Pro Pro 85 90 95 Asp Pro Asp Thr Pro Pro Gln Gln Gln Gln Asn Gln Ala Gln Ala His 100 105 110 Ala Pro Pro Gln Pro Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu 115 120 125 Ala Glu Pro Gln Arg Ala Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu 130 135 140 Thr Gly Gly Asp Asp 145 <210> 96 <211> 490 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 96 Met Phe Ser Val Ser Ser Thr Ser Leu Pro Ser Ser Gln Leu Trp Tyr 1 5 10 15 Cys Arg Pro Arg Arg Ala Ala Asn Phe Leu His Thr Leu Lys Gly Met 20 25 30 Ser Asn Ser Ser Cys Pro Ser Ile Phe Ile Phe Ile Phe Tyr Gln Met 35 40 45 Ser Lys Lys Arg Ala Arg Val Asp Asp Gly Phe Asp Pro Val Tyr Pro 50 55 60 Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro Phe 65 70 75 80 Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser Leu 85 90 95 Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Ala Val Thr Leu Lys 100 105 110 Leu Gly Glu Gly Val Asp Leu Asp Asp Ser Gly Lys Leu Ile Ser Lys 115 120 125 Asn Ala Thr Lys Ala Thr Ala Pro Leu Ser Ile Ser Asn Gly Thr Ile 130 135 140 Ser Leu Asn Met Ala Ala Pro Phe Tyr Asn Asn Asn Gly Thr Leu Ser 145 150 155 160 Leu Asn Val Ser Thr Pro Leu Ala Val Phe Pro Thr Phe Asn Thr Leu 165 170 175 Gly Ile Ser Leu Gly Asn Gly Leu Gln Thr Ser Asn Lys Leu Leu Thr 180 185 190 Val Gln Leu Thr His Pro Leu Thr Phe Ser Ser Asn Ser Ile Thr Val 195 200 205 Lys Thr Asp Lys Gly Leu Tyr Ile Asn Ser Ser Gly Asn Arg Gly Leu 210 215 220 Glu Ala Asn Ile Ser Leu Lys Arg Gly Leu Ile Phe Asp Gly Asn Ala 225 230 235 240 Ile Ala Thr Tyr Leu Gly Ser Gly Leu Asp Tyr Gly Ser Tyr Asp Ser 245 250 255 Asp Gly Lys Thr Arg Pro Ile Ile Thr Lys Ile Gly Ala Gly Leu Asn 260 265 270 Phe Asp Ala Asn Asn Ala Met Ala Val Lys Leu Gly Thr Gly Leu Ser 275 280 285 Phe Asp Ser Ala Gly Ala Leu Thr Ala Gly Asn Lys Glu Asp Asp Lys 290 295 300 Leu Thr Leu Trp Thr Thr Pro Asp Pro Ser Pro Asn Cys Gln Leu Leu 305 310 315 320 Ser Asp Arg Asp Ala Lys Phe Thr Leu Cys Leu Thr Lys Cys Gly Ser 325 330 335 Gln Ile Leu Gly Thr Val Ala Val Ala Ala Val Thr Val Gly Ser Ala 340 345 350 Leu Asn Pro Ile Asn Asp Thr Val Lys Ser Ala Ile Val Phe Leu Arg 355 360 365 Phe Asp Ser Asp Gly Val Leu Met Ser Asn Ser Ser Met Val Gly Asp 370 375 380 Tyr Trp Asn Phe Arg Glu Gly Gln Thr Thr Gln Ser Val Ala Tyr Thr 385 390 395 400 Asn Ala Val Gly Phe Met Pro Asn Leu Gly Ala Tyr Pro Lys Thr Gln 405 410 415 Ser Lys Thr Pro Lys Asn Ser Ile Val Ser Gln Val Tyr Leu Asn Gly 420 425 430 Glu Thr Thr Met Pro Met Thr Leu Thr Ile Thr Phe Asn Gly Thr Asp 435 440 445 Glu Lys Asp Thr Thr Pro Val Ser Thr Tyr Ser Met Thr Phe Thr Trp 450 455 460 Gln Trp Thr Gly Asp Tyr Lys Asp Lys Asn Ile Thr Phe Ala Thr Asn 465 470 475 480 Ser Phe Thr Phe Ser Tyr Met Ala Gln Glu 485 490 <210> 97 <211> 31980 <212> DNA <213> Unknown <220> <223> Simian adenovirus A1337 <220> <221> CDS <222> (1906)..(3405) <223> E1b\55K <220> <221> CDS <222> (25519)..(26070) <223> 22K <220> <221> CDS <222> (27376)..(28011) <223> E3\CR1-alpha <220> <221> CDS <222> (31565)..(31966) <223> E3\14.7K <400> 97 catcatcaat aatatacctc aaactttttg tgcgcgttaa tatgcaaatg aggcgtttga 60 atttgggaag ggaggaaggt gattggccga gagaagggcg accgttaggg gcggggcgag 120 tgacgttttg atgacgtggc cgcgaggagg agccagtttg caagttctcg tgggaaaagt 180 gacgtcaaac gaggtgtggt ttgaacacgg aaatactcaa ttttcccgcg ctctctgaca 240 ggaaatgagg tgtttttggg cggatgcaag ttaaaacggg ccattttcgc gcgaaaactg 300 aatgaggaag tgaaaatctg agtaatttcg cgtttatggc agggaggagt atttgccgag 360 ggccgagtag actttgaccg attacgtggg ggtttcgatt accgtgtttt tcacctaaat 420 ttccgcgtac ggtgtcaaag tccggtgttt ttacgtaggt gtcagctgat cgccagggta 480 tttaaacctg cgctctccag tcaagaggcc actcttgagt gccagcgaga agagttttct 540 cctccgcgcc gcgagtcaga tctacacttt gaaagatgag gcacctgaga gacctgcccg 600 atgagaaaat catcatcgct tccgggaacg agattctgga actggtggta aatgccatga 660 tgggcgacga ccctccggag ccccccaccc catttgaggt accttcgcta cacgatttgt 720 atgatctgga ggtggatgtg cccgaggacg accccaacga ggaggcggta aatgatttat 780 ttagcgatgc cgcgctgcta gctgccgagg aggcttcgag ccctagctca gacagcgact 840 cttcactgca tacccctaga cccggcagag gtgagaaaaa gatccccgag cttaaagggg 900 aagagatgga cttgcgctgc tatgaggaat gcttgccccc gagcgatgat gaggacgagc 960 aggcgatcca gaacgcagcg agccagggag tgcaagccgc cagcgagagc tttgcgctgg 1020 actgcccgcc tctgcccgga cacggctgta agtcttgtga atttcatcgc atgaatactg 1080 gagataaagc tgtgttatgt gcactttgct atatgagagc ttacaaccat tgtgtttaca 1140 gtaagtgtga ttaagttgaa ctttagaggg aggcagagag cagggtgact gggcgatgac 1200 tggtttattt atgtatatat gttctttata taggtcccgt ctctgacgca gatgatgaga 1260 cccccactac agagtccact tcgtcacccc cagaaattgg cacatctcca cctgagaata 1320 ttgttagacc agttcctgtt agagccactg ggaggagagc agctgtggaa tgtttggatg 1380 acttgctaca gggtggggat gaacctttgg acttgtgtac ccggaaacgc cccaggcact 1440 aagtgccaca catgtgtgtt tacttgaggt gatgtcagta tttatagggt gtggagtgca 1500 ataaaaaatg tgttgacttt aagtgcgtgg tttatgactc aggggtgggg actgtgggta 1560 tataagcagg tgcagacctg tgtggttagc tcagagcggc atggagattt ggacggtctt 1620 ggaagacttt cacaagacta gacagctgct agagaacgcc tcgaacggag tctcttacct 1680 gtggagattc tgcttcggtg gcgacctagc taggctagtc tacagggcca aacaggatta 1740 tagtgaacaa tttgaggtta ttttgagaga gtgtcctggt ctttttgacg ctcttaactt 1800 gggccatcag tctcacttta accagaggat ttcgagagcc cttgacttta ctactcctgg 1860 cagaaccact gcagcagtag ccttttttgc ttttattctt gacaa atg gag tca aga 1917 Met Glu Ser Arg 1 aac cca ttt cag cag gga tta cca gct gga ttt ctt agc agt agc ttt 1965 Asn Pro Phe Gln Gln Gly Leu Pro Ala Gly Phe Leu Ser Ser Ser Phe 5 10 15 20 gtg gag aac atg gaa gtg cca gcg cct gaa tgc aat ctc cgg cta ctt 2013 Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn Leu Arg Leu Leu 25 30 35 gcc ggt aca gcc gct aga cac tct gag gat cct gaa tct cca gga gag 2061 Ala Gly Thr Ala Ala Arg His Ser Glu Asp Pro Glu Ser Pro Gly Glu 40 45 50 tcc cag ggc acg cca acg tcg cca gca gca gca gcg gca gca gga gga 2109 Ser Gln Gly Thr Pro Thr Ser Pro Ala Ala Ala Ala Ala Ala Gly Gly 55 60 65 gga tca aga aga gaa ccc gag agc cgg cct gga ccc tcc gga gga gga 2157 Gly Ser Arg Arg Glu Pro Glu Ser Arg Pro Gly Pro Ser Gly Gly Gly 70 75 80 gga gga gta gct gac ctg ttt cct gaa ctg cgc cgg gtg ctg act agg 2205 Gly Gly Val Ala Asp Leu Phe Pro Glu Leu Arg Arg Val Leu Thr Arg 85 90 95 100 tct tcg agt ggt cgg gag agg ggg att aag cgg gag agg cat gat gag 2253 Ser Ser Ser Gly Arg Glu Arg Gly Ile Lys Arg Glu Arg His Asp Glu 105 110 115 act aat cac aga act gaa ctg act gtc agt ctg atg agc cgc aag cgc 2301 Thr Asn His Arg Thr Glu Leu Thr Val Ser Leu Met Ser Arg Lys Arg 120 125 130 cca gaa aca gtg tgg tgg cat gag gtg cag tcg act ggc aca gat gag 2349 Pro Glu Thr Val Trp Trp His Glu Val Gln Ser Thr Gly Thr Asp Glu 135 140 145 gtg tca gtg atg cat gag aag ttt tct cta gaa caa gtc aag act tgt 2397 Val Ser Val Met His Glu Lys Phe Ser Leu Glu Gln Val Lys Thr Cys 150 155 160 tgg tta gag cct gag gat gat tgg gaa gta gcc atc agg aat tat gcc 2445 Trp Leu Glu Pro Glu Asp Asp Trp Glu Val Ala Ile Arg Asn Tyr Ala 165 170 175 180 aag ctg gct ctg atg cca gac aag aag tac aag att act aag ctg ata 2493 Lys Leu Ala Leu Met Pro Asp Lys Lys Tyr Lys Ile Thr Lys Leu Ile 185 190 195 aat atc aga aat gcc tgc tac atc tca ggg aat ggg gct gaa gtg gag 2541 Asn Ile Arg Asn Ala Cys Tyr Ile Ser Gly Asn Gly Ala Glu Val Glu 200 205 210 att tgt ctc cag gat aga gtg gct ttc aga tgc tgc atg atg aat atg 2589 Ile Cys Leu Gln Asp Arg Val Ala Phe Arg Cys Cys Met Met Asn Met 215 220 225 tac ccg gga gtg gtg ggc atg gat ggg gtc acc ttt atg aac atg agg 2637 Tyr Pro Gly Val Val Gly Met Asp Gly Val Thr Phe Met Asn Met Arg 230 235 240 ttc agg gga gat ggg tat aat ggt acg gtc ttt atg gcc aat acc aag 2685 Phe Arg Gly Asp Gly Tyr Asn Gly Thr Val Phe Met Ala Asn Thr Lys 245 250 255 260 ctg aca gtc cat ggc tgc tcc ttc ttt ggg ttt aat aac act tgc att 2733 Leu Thr Val His Gly Cys Ser Phe Phe Gly Phe Asn Asn Thr Cys Ile 265 270 275 gag gcc tgg ggc cag gta ggc gtg agg ggc tgc agt ttt tca gcc aac 2781 Glu Ala Trp Gly Gln Val Gly Val Arg Gly Cys Ser Phe Ser Ala Asn 280 285 290 tgg atg ggg gtc gtg ggc agg acc aag agt atg ctg tcc gtg aag aaa 2829 Trp Met Gly Val Val Gly Arg Thr Lys Ser Met Leu Ser Val Lys Lys 295 300 305 tgc ttg ttt gag agg tgc cac ctg ggg gtg atg agc gag ggc gaa gcc 2877 Cys Leu Phe Glu Arg Cys His Leu Gly Val Met Ser Glu Gly Glu Ala 310 315 320 aga atc cgc cac tgc gcc tct acc gag acg ggc tgc ttc gtg ctg tgc 2925 Arg Ile Arg His Cys Ala Ser Thr Glu Thr Gly Cys Phe Val Leu Cys 325 330 335 340 aag ggc aat gcc aag atc aag cat aat atg atc tgt gga gcc tcg gac 2973 Lys Gly Asn Ala Lys Ile Lys His Asn Met Ile Cys Gly Ala Ser Asp 345 350 355 gag cgc ggc tac cag atg ctg acc tgt gcc ggt ggg aac agc cat atg 3021 Glu Arg Gly Tyr Gln Met Leu Thr Cys Ala Gly Gly Asn Ser His Met 360 365 370 ctg gcc acc gtg cat gtg gct tcc cat gcc cgc aag ccc tgg ccc gag 3069 Leu Ala Thr Val His Val Ala Ser His Ala Arg Lys Pro Trp Pro Glu 375 380 385 ttc gag cac aat gtc atg acc agg tgc aat atg cat ctg ggg tct cgc 3117 Phe Glu His Asn Val Met Thr Arg Cys Asn Met His Leu Gly Ser Arg 390 395 400 cga ggc atg ttc atg ccc tac cag tgc aac ctg aat tat gtg aag gtg 3165 Arg Gly Met Phe Met Pro Tyr Gln Cys Asn Leu Asn Tyr Val Lys Val 405 410 415 420 ctg ctg gag ccc gat gcc atg tcc aga gtg agc ctg acg ggg gtg ttt 3213 Leu Leu Glu Pro Asp Ala Met Ser Arg Val Ser Leu Thr Gly Val Phe 425 430 435 gac atg aat gtg gag gtg tgg aag att ctg aga tat gat gaa tcc aag 3261 Asp Met Asn Val Glu Val Trp Lys Ile Leu Arg Tyr Asp Glu Ser Lys 440 445 450 acc agg tgc cga gcc tgc gag tgc gga ggg aag cat gcc agg ttc cag 3309 Thr Arg Cys Arg Ala Cys Glu Cys Gly Gly Lys His Ala Arg Phe Gln 455 460 465 ccc gtg tgt gtg gat gtg acg gag gac ctg cga ccc gat cat ttg gtg 3357 Pro Val Cys Val Asp Val Thr Glu Asp Leu Arg Pro Asp His Leu Val 470 475 480 ttg tcc tgc acc ggg acg gag ttc ggt tcc agc ggg gaa gaa tct gac 3405 Leu Ser Cys Thr Gly Thr Glu Phe Gly Ser Ser Gly Glu Glu Ser Asp 485 490 495 500 tagagtgagt agtgttctgg ggcgggggag gacctgcatg agggccagaa tgattgaaat 3465 ctgtgctttt ctgtgtgttg cagcagcatg agcggaagcg gctcctttga gggaggggta 3525 ttcagccctt atctgacggg gcgtctcccc tcctgggcgg gagtgcgtca gaatgtgatg 3585 ggatccacgg tggacggccg gcccgtgcag cccgcgaact cttcaaccct gacctatgca 3645 accctgagct cttcgtcggt ggacgcagct gccgccgcag ctgctgcatc tgccgccagc 3705 gccgtgcgcg gaatggccat gggcgccggc tactacggca ctctggtggc caactcgagt 3765 tccaccaata atcccgccag cctgaacgag gagaagctgc tgctgctgat ggcccagctc 3825 gaggccttga cccagcgcct gggcgagctg acccagcagg tggctcagct gcaggagcag 3885 acgcgggccg cggttgccac ggtgaaatcc aaataaaaaa tgaatcaata aataaacgga 3945 gacggttgtt gattttaaca cagagtctga atctttattt gatttttcgc gcgcggtagg 4005 ccctggacca ccggtctcga tcattgagca ctcggtggat cttttccagg acccggtaga 4065 ggtgggcttg gatgttgagg tacatgggca tgagcccgtc ccgggggtgg aggtagctcc 4125 attgcagggc ctcgtgctcg ggggtggtgt tgtaaatcac ccagtcatag caggggcgca 4185 gggcatggtg ttgcacaata tctttgagga ggagactgat ggccacgggc agccctttgg 4245 tgtaggtgtt tacaaatctg ttgagctggg agggatgcat gcggggggag atgaggtgca 4305 tcttggcctg gatcttgaga ttggcgatgt taccgcccag atcccgcctg gggttcatgt 4365 tgtgcaggac caccagcacg gtgtatccgg tgcacttggg gaatttatca tgcaacttgg 4425 aagggaaggc gtgaaagaat ttggcgacgc ccttgtgccc gcccaggttt tccatgcact 4485 catccatgat gatggcgatg gggccgtggg cggcggcctg ggcaaaaacg tttcgggggt 4545 cggacacatc atagttgtgg tcctgggtga gatcatcata ggccatttta atgaatttgg 4605 ggcggagggt gccggactgg gggacaaagg taccctcgat cccgggggcg tagttcccct 4665 cacagatctg catctcccag gctttgagct cggagggggg gatcatgtcc acctgcgggg 4725 cgataaagaa cacggtttcc ggggcgggag agatgagctg ggccgaaagc aagttccgga 4785 gcagctggga cttgccgcag ccggtggggc cgtagatgac cccgatgacc ggttgcaggt 4845 ggtagttgag ggagagacag ctgccgtcct cccggaggag gggggccacc tcgttcatca 4905 tctcgcgcac gtgcatgttc tcgcgcacca gttccgccag gaggcgctct ccccccaggg 4965 ataggagctc ctggagcgag gcgaagtttt tcagcggctt gagtccgtcg gccatgggca 5025 ttttggagag ggtctgttgc aagagttcca agcggtccca gagctcggtg atgtgctcta 5085 cggcatctcg atccagcaga cctcctcgtt tcgcgggttg gggcggctgc gggagtaggg 5145 caccagacga tgggcgtcca gcgcagccag ggtccggtcc ttccagggtc gcagcgtccg 5205 cgtcagggtg gtctccgtca cggtgaaggg gtgcgcgccg ggctgggcgc ttgcgagggt 5265 gcgcttcagg ctcatccggc tggtcgaaaa ccgctcccga tcggcgccct gcgcgtcggc 5325 caggtagcaa ttgaccatga gttcgtaatt gagcgcctcg gccgcgtgac ctttggcgcg 5385 gagcttacct ttggaagtct gcccgcaggt gggacagagg agggacttga gggcgtagag 5445 cttgggggcg aggaagacgg actcgggggc gtaggcgtcc gcgccgcagt gggcgcagac 5505 ggtctcgcac tccacgagcc aggtgaggtc gggctggtcg gggtcaaaaa ccagtttccc 5565 gccgttcttt ttgatgcgtt tcttaccttt ggtctccatg agctcgtgtc cccgctgggt 5625 gacaaagagg ctgtccgtgt ccccgtagac cgactttatg ggccggtcct cgagcggtgt 5685 gccgcggtcc tcctcgtaga ggaaccccgc ccactccgag acgaaagccc gggtccaggc 5745 cagcacgaag gaggccacgt gggacgggta gcggtcgttg tccaccagcg ggtccacctt 5805 ctccagggta tgcaaacaca tgtccccctc gtccacatcc aggaaggtga ttggcttgta 5865 agtgtaggcc acgtgaccgg gggtcccagc cgggggggta taaaaggggg cgggcccctg 5925 ctcgtcctca ctgtcttccg gatcgctgtc caggagcgcc agctgttggg gtaggtattc 5985 cctctcgaag gcgggcatga cctcggcact caggttgtca gtttctagaa acgaggagga 6045 tttgatattg acggtgccgg cggagatgcc tttcaagagc ccctcgtcca tctggtcaga 6105 aaagacgatc tttttgttgt cgagtttggt ggcgaaggag ccgtagaggg cattggagag 6165 gagcttggcg atagagcgca tggtctggtt tttttccttg tcggcgcgct ccttggccgc 6225 gatgttgagc tgcacgtact cgcgcgccac gcacttccat tcggggaaga cggtggtcag 6285 ctcgtcgggc acgattctga cttgccagcc ccggttatgc agggtgatga ggtccacact 6345 ggtgcccacc tcgccgcgca ggggctcgtt ggtccagcag agtcgaccgc ccttgcgcga 6405 gcagaagggg ggcagggggt ccagcatgac ctcgtcgggg gggtcggcat cgatggtgaa 6465 gatgcctggc aggagatcgg ggtcgaagta gctgatggaa gtggccagat cgtccagggc 6525 agcttgccat tcgcgcacgg ccagcgcgcg ctcgtaggga ctgaggggcg tgccccaagg 6585 catggggtgt gtgagcgcgg aggcgtacat gccgcagatg tcgtagacgt agaggggctc 6645 ctcgaggatg ccgatgtagg tggggtaaca gcgccccccg cggatgctgg cgcgcacgta 6705 gtcatacagc tcatgcgagg gggcgaggag ccccgggccc aggttggtgc gactgggctt 6765 ttcggcgcgg tagacgatct ggcgaaagat ggcatgcgag ttggaggaga tggtgggcct 6825 ttggaagatg ttgaagtggg cgtggggcag accgaccgag tcgcggatga agtgggcgta 6885 ggagtcttgc agtttggcga cgagctcggc ggtgacgagg acgtccagag cgcagtagtc 6945 gagggtctcc tggatgatgt catacttgag ctggcccttt tgtttccaca gctcgcggtt 7005 gagaaggaac tcttcgcggt ccttccagta ctcttcgagg gggaacccgt cctgatctgc 7065 acggtaagag cctagcatgt agaactggtt gacggccttg taggcgcagc agcccttctc 7125 cacggggagg gcgtaggcct gggcggcctt gcgcagggag gtgtgcgtga gggcgaaggt 7185 gtccctgacc atgaccttga ggaactggtg cttgaaatcg atatcgtcgc agcccccctg 7245 ctcccagagc tggaagtccg tgcgcttctt gtaggcgggg ttgggcaaag cgaaagtaac 7305 atcgttgaaa aggatcttgc ccgcgcgggg cataaagttg cgagtgatgc ggaaaggctg 7365 gggcacctcg gcccggttgt tgatgacctg ggcggcgagc acgatctcgt cgaaaccgtt 7425 gatgttgtgg cccacgatgt agagttccac gaatcgcggg cggcccttga cgtggggcag 7485 cttcttgagc tcctcgtagg tgagctcgtc ggggtcgctg agaccgtgct gctcgagcgc 7545 ccagtcggcg agatgggggt tggcgcggag gaaggaagtc cagagatcca cggccagggc 7605 ggtttgcaga cggtcccggt actgacggaa ctgctgcccg acggccattt tttcgggggt 7665 gacgcagtag aaggtgcggg ggtccccgtg ccagcggtcc catttgagct ggagggcgag 7725 atcgagggcg agctcgacga ggcggtcgtc cccggagagt ttcatgacca gcatgaaggg 7785 gacgagctgc ttgccgaagg accccatcca ggtgtaggtt tccacatcgt aggtgaggaa 7845 gagcctttcg gtgcgaggat gcgagccgat ggggaagaac tggatctcct gccaccaatt 7905 ggaggaatgg ctgttgatgt gatggaagta gaaatgccga cggcgcgccg aacactcgtg 7965 cttgtgttta tacaagcggc cacagtgctc gcaacgctgc acgggatgca cgtgctgcac 8025 gagctgtacc tgagttcctt tgacgaggaa tttcagtggg aagtggagtc gtggcgcctg 8085 catctcgtgc tgtactacgt cgtggtggtc ggcctggccc tcttctgcct cgatggtggt 8145 catgctgacg agcccgcgcg ggaggcaggt ccagacctcg gcgcgagcgg gtcggagagc 8205 gaggacgagg gcgcgcaggc cggagctgtc cagggtcctg agacgctgcg gagtcaggtc 8265 agtgggcagc ggcggcgcgc ggttgacttg caggagtttt tccagggcgc gcgggaggtc 8325 cagatggtac ttgatctcca ccgcgccgtt ggtggcgacg tcgatggctt gcagggtccc 8385 gtgcccctgg ggtgtgacca ccgtcccccg tttcttcttg ggcggctggg gcgacggggg 8445 cggtgcctct tccatggtta gaagcggcgg cgaggacgcg cgccgggcgg cagaggcggc 8505 tcggggcccg gaggcagggg cggcaggggc acgtcggcgc cgcgcgcggg taggttctgg 8565 tactgcgccc ggagaagact ggcgtgagcg acgacgcgac ggttgacgtc ctggatctga 8625 cgcctctggg tgaaggccac gggacccgtg agtttgaacc tgaaagagag ttcgacagaa 8685 tcaatctcgg tatcgttgac ggcggcctgc cgcaggatct cttgcacgtc gcccgagttg 8745 tcctggtagg cgatctcggt catgaactgc tcgatctcct cctcctgaag gtctccgcgg 8805 ccggcgcgct ccacggtggc cgcgaggtcg ttggagatgc ggcccatgag ctgcgagaag 8865 gcgttcatgc ccgcctcgtt ccagacgcgg ctgtagacca cgacgccctc gggatcgcgg 8925 gcgcgcatga ccacctgggc gaggttgagc tccacgtggc gcgtgaagac cgcgtagttg 8985 cagaggcgct ggtagaggta gttgagcgtg gtggcgatgt gctcggtgac gaagaaatac 9045 atgatccagc ggcggagcgg catctcgctg acgtcgccca gcgcctccaa gcgttccatg 9105 gcctcgtaaa agtccacggc gaagttgaaa aactgggagt tgcgcgccga gacggtcaac 9165 tcctcctcca gaagacggat gagctcggcg atggtggcgc gcacctcgcg ctcgaaggcc 9225 cccgggagtt cctcctcttc catctcctct tcttcctcct ccactaacat ctcttctact 9285 tcctcctcag gcggtggtgg cgggggaggg ggcctgcgtc gccggcggcg cacgggcaga 9345 cggtcgatga agcgctcgat ggtctcgccg cgccggcgtc gcatggtctc ggtgacggcg 9405 cgcccgtcct cgcggggccg cagcgtgaag acgccgccgc gcatctccag gtggccgggg 9465 gggtccccgt tgggcaggga gagggcgctg acgatgcatc ttatcaattg ccccgtaggg 9525 actccgcgca aggacctgag cgtctcgaga tccacgggat ctgaaaaccg ttgaacgaag 9585 gcttcgagcc agtcgcagtc gcaaggtagg ctgagcacgg tttcttctgg cgggtcatgt 9645 tggggagcgg ggcgggcgat gctgctggtg atgaagttga aataggcggt tctgagacgg 9705 cggatggtgg cgaggagcac caggtctttg ggcccggctt gctggatgcg cagacggtcg 9765 gccatgcccc aggcgtggtc ctgacacctg gccaggtcct tgtagtagtc ctgcatgagc 9825 cgctccacgg gcacctcctc ctcgcccgcg cggccgtgca tgcgcgtgag cccgaagccg 9885 cgctggggct ggacgagcgc caggtcggcg acgacgcgct cggcgaggat ggcctgctgg 9945 atctgggtga gggtggtctg gaagtcgtca aagtcgacga agcggtggta ggctccggtg 10005 ttgatggtgt aggagcagtt ggccatgacg gaccagttga cggtctggtg gcccggacgc 10065 acgagctcgt ggtacttgag gcgcgagtag gcgcgcgtgt cgaagatgta gtcgttgcag 10125 gtgcgcacca ggtactggta gccgatgagg aagtgcggcg gcggctggcg gtagagcggc 10185 catcgctcgg tggcgggggc gccgggcgcg aggtcctcga gcatggtgcg gtggtagccg 10245 tagatgtacc tggacatcca ggtgatgccg gcggcggtgg tggaggcgcg cgggaactcg 10305 cggacgcggt tccagatgtt gcgcagcggc aggaagtagt tcatggtggg cacggtctgg 10365 cccgtgaggc gcgcgcagtc gtggatgctc tatacgggca aaaacgaaag cggtcagcgg 10425 ctcgactccg tggcctggag gctaagcgaa cgggttgggc tgcgcgtgta ccccggttcg 10485 aatctcgaat caggctggag ccgcagctaa cgtggtactg gcactcccgt ctcgacccaa 10545 gcctgcacca accctccagg atacggaggc gggtcgtttt gcaacttttt ttcggaggcc 10605 ggaaatgaag actagtaagc gcggaaagcg gccgaccgcg atggctcgct gccgtagtct 10665 ggagaagaat cgccagggtt gcgttgcggt gtgccccggt tcgaggccgg ccggattccg 10725 cggctaacga gggcgtggct gccccgtcgt ttccaagacc ccctagccag ccgacttctc 10785 cagttacgga gcgagcccct cttttgtttt gtttgttttt gccagatgca tcccgtactg 10845 cggcagatgc gcccccacca ccctccaccg caacaacagc cccctccaca gccggcgctt 10905 ctgcccccgc cccagcagca gcagcaactt ccagccacga ccgccgcggc cgccgtgagc 10965 ggggctggac agacttctca gtatgacctg gccttggaag agggcgaggg gctggcgcgc 11025 ctgggggcgt cgtcgccgga gcggcacccg cgcgtgcaga tgaaaaggga cgctcgcgag 11085 gcctacgtgc ccaagcagaa cctgttcaga gacaggagcg gcgaggagcc cgaggagatg 11145 cgcgcggccc ggttccacgc ggggcgggag ctgcggcgcg gcctggaccg aaagagggtg 11205 ctgagggacg aggatttcga ggcggacgag ctgacgggga tcagccccgc gcgcgcgcac 11265 gtggccgcgg ccaacctggt cacggcgtac gagcagaccg tgaaggagga gagcaacttc 11325 caaaaatcct tcaacaacca cgtgcgcacc ctgatcgcgc gcgaggaggt gaccctgggc 11385 ctgatgcacc tgtgggacct gctggaggcc atcgtgcaga accccaccag caagccgctg 11445 acggcgcagc tgttcctggt ggtgcagcat agtcgggaca acgaggcgtt cagggaggcg 11505 ctgctgaata tcaccgagcc cgagggccgc tggctcctgg acctggtgaa cattctgcag 11565 agcatcgtgg tgcaggagcg cgggctgccg ctgtccgaga agctggcggc catcaacttc 11625 tcggtgctga gtctgggcaa gtactacgct aggaagatct acaagacccc gtacgtgccc 11685 atagacaagg aggtgaagat cgacgggttt tacatgcgca tgaccctgaa agtgctgacc 11745 ctgagcgacg atctgggggt gtaccgcaac gacaggatgc accgcgcggt gagcgccagc 11805 aggcggcgcg agctgagcga ccaggagctg atgcatagtc tgcagcgggc cctgaccggg 11865 gccgggaccg agggggagag ctactttgac atgggcgcgg acctgcactg gcagcccagc 11925 cgccgggcct tggaggcggc aggcggtccc ccctacatag aagaggtgga cgatgaggtg 11985 gacgaggagg gcgagtacct ggaagactga tggcgcgacc gtatttttgc tagatgcaac 12045 aacagccacc tcctgatccc gcgatgcggg cggcgctgca gagccagccg tccggcatta 12105 actcctcgga cgattggacc caggccatgc aacgcatcat ggcgctgacg acccgcaacc 12165 ccgaagcctt tagacagcag ccccaggcca accggctctc ggccatcctg gaggccgtgg 12225 tgccctcgcg ctccaacccc acgcacgaga aggtcctggc catcgtgaac gcgctggtgg 12285 agaacaaggc catccgcggc gacgaggccg gcctggtgta caacgcgctg ctggagcgcg 12345 tggcccgcta caacagcacc aacgtgcaga ccaacctgga ccgcatggtg accgacgtgc 12405 gcgaggccgt ggcccagcgc gagcggttcc accgcgagtc caacctggga tccatggtgg 12465 cgctgaacgc cttcctcagc acccagcccg ccaacgtgcc ccggggccag gaggactaca 12525 ccaacttcat cagcgccctg cgcctgatgg tgaccgaggt gccccagagc gaggtgtacc 12585 agtccgggcc ggactacttc ttccagacca gtcgccaggg cttgcagacc gtgaacctga 12645 gccaggcgtt caagaacttg cagggcctgt ggggcgtgca ggccccggtc ggggaccgcg 12705 cgacggtgtc gagcctgctg acgccgaact cgcgcctgct gctgctgctg gtggccccct 12765 tcacggacag cggcagcatc aaccgcaact cgtacctggg ctacctgatt aacctgtacc 12825 gcgaggccat cggccaggcg cacgtggacg agcagaccta ccaggagatc acccacgtga 12885 gccgcgccct gggccaggac gacccgggca atctggaagc caccctgaac tttttgctga 12945 ccaaccggtc gcagaagatc ccgccccagt acacgctcag cgccgaggag gagcgcatcc 13005 tgcgatacgt gcagcagagc gtgggcctgt tcctgatgca ggagggggcc acccccagcg 13065 ccgcgctcga catgaccgcg cgcaacatgg agcccagcat gtacgccagc aaccgcccgt 13125 tcatcaataa actgatggac tacttgcatc gggcggccgc catgaactct gactatttca 13185 ccaacgccat cctgaatccc cactggctcc cgccgccggg gttctacacg ggcgagtacg 13245 acatgcccga ccccaatgac gggttcctgt gggacgatgt ggacagcagc gtgttctccc 13305 cccgaccggg tgctaacgag cgccccttgt ggaagaagga aggcagcgac cgacgcccgt 13365 cctcggcgct gtccggccgc gagggtgctg ccgcggcggt gcccgaggcc gccagtcctt 13425 tcccgagctt gcccttctcg ctgaacagta ttcgcagcag cgagctgggc aggatcacgc 13485 gcccgcgctt gctgggcgag gaggagtact tgaatgactc gctgttgaga cccgagcggg 13545 agaagaactt ccccaataac gggatagaga gcctggtgga caagatgagc cgctggaaga 13605 cgtatgcgca ggagcacagg gacgatccgt cgcagggggc cacgagccgg ggcagcgccg 13665 cccgtaaacg ccggtggcac gacaggcagc ggggactgat gtgggacgat gaggattccg 13725 ccgacgacag cagcgtgttg gacttgggtg ggagtggtaa cccgttcgct cacctgcgcc 13785 cccgcatcgg gcgcatgatg taagagaaac cgaaaataaa tgatactcac caaggccatg 13845 gcgaccagcg tgcgttcgtt tcttctctgt tgttgtatct agtatgatga ggcgtgcgta 13905 cccggagggt cctcctccct cgtacgagag cgtgatgcag caggcgatgg cggcggcggc 13965 ggcgatgcag cccccgctgg aggctcctta cgtgcccccg cggtacctgg cgcctacgga 14025 ggggcggaac agcattcgtt actcggagct ggcacccttg tacgatacca cccggttgta 14085 cctggtggac aacaagtcgg cggacatcgc ctcgctgaac taccagaacg accacagcaa 14145 cttcctgacc accgtggtgc agaacaatga cttcaccccc acggaggcca gcacccagac 14205 catcaacttt gacgagcgct cgcggtgggg cggtcagctg aaaaccatca tgcacaccaa 14265 catgcccaac gtgaacgagt tcatgtacag caacaagttc aaggcgcggg tgatggtctc 14325 ccgcaagacc cccaacgggg tgacagtgac agatggtagt caggatatct tggagtatga 14385 atgggtggag tttgagctgc ccgaaggcaa cttctcggtg accatgacca tcgacctgat 14445 gaacaacgcc atcatcgaca attacttggc ggtggggcgg cagaacgggg tcctggagag 14505 cgatatcggc gtgaagttcg acactaggaa cttcaggctg ggctgggacc ccgtgaccga 14565 gctggtcatg cccggggtgt acaccaacga ggccttccac cccgatattg tcttgctgcc 14625 cggctgcggg gtggacttca ccgagagccg cctcagcaac ctgctgggca ttcgcaagag 14685 gcagcccttc caggagggct tccagatcat gtacgaggat ctggaggggg gcaacatccc 14745 cgcgctcctg gatgtcgacg cctatgagaa aagcaaggag gagagcgccg ccgcggcgac 14805 tgcagctgta gccaccgcct ctaccgaggt caggggcgat aattttgcca gccctgcagc 14865 agtggcagcg gccgaggcgg ctgaaaccga aagtaagata gtcattcagc cggtggagaa 14925 ggatagcaag gacaggagct acaacgtgct gccggacaag ataaacaccg cctaccgcag 14985 ctggtacctg gcctacaact atggcgaccc cgagaagggc gtgcgctcct ggacgctgct 15045 caccacctcg gacgtcacct gcggcgtgga gcaagtctac tggtcgctgc ccgacatgat 15105 gcaagacccg gtcaccttcc gctccacgcg tcaagttagc aactacccgg tggtgggcgc 15165 cgagctcctg cccgtctact ccaagagctt cttcaacgag caggccgtct actcgcagca 15225 gctgcgcgcc ttcacctcgc tcacgcacgt cttcaaccgc ttccccgaga accagatcct 15285 cgtccgcccg cccgcgccca ccattaccac cgtcagtgaa aacgttcctg ctctcacaga 15345 tcacgggacc ctgccgctgc gcagcagtat ccggggagtc cagcgcgtga ccgttactga 15405 cgccagacgc cgcacctgcc cctacgtcta caaggccctg ggcatagtcg cgccgcgcgt 15465 cctctcgagc cgcaccttct aaaaaatgtc cattctcatc tcgcccagta ataacaccgg 15525 ttggggcctg cgcgcgccca gcaagatgta cggaggcgct cgccaacgct ccacgcaaca 15585 ccccgtgcgc gtgcgcgggc acttccgcgc tccctggggc gccctcaagg gccgcgtgcg 15645 gtcgcgcacc accgtcgacg acgtgatcga ccaggtggtg gccgacgcgc gcaactacac 15705 ccccgccgcc gcgcccgtct ccaccgtgga cgccgtcatc gacagcgtgg tggccgacgc 15765 gcgccggtac gcccgcgcca agagccggcg gcggcgcatc gcccggcggc accggagcac 15825 ccccgccatg cgcgcggcgc gagccttgct gcgcagggcc aggcgcacgg gacgcagggc 15885 catgctcagg gcggccagac gcgcggcctc aggcgccagc gccggcagga cccggagacg 15945 cgcggccacg gcggcggcag cggccatcgc cagcatgtcc cgcccgcggc gagggaacgt 16005 gtactgggtg cgcgacgccg ccaccggtgt gcgcgtgccc gtgcgcaccc gcccccctcg 16065 cacttgaaga tgttcacttc gcgatgttga tgtgtcccag cggcgaggat gtccaagcgc 16125 aaattcaagg aagagatgct ccaggtcatc gcgcctgaga tctacggccc cgcggtggtg 16185 aaggaggaaa gaaagccccg caaaatcaag cgggtcaaaa aggacaaaaa ggaagaagaa 16245 agtgatgtgg acggactggt ggagtttgtg cgcgagttcg ccccccggcg gcgcgtgcag 16305 tggcgcgggc ggaaggtgcg cccggtgctg agaccaggca ctacggtggt cttcacgccc 16365 ggcgagcgct ccggcaccgc ttccaagcgc tcctacgacg aggtgtacgg ggacgaggac 16425 atcctcgagc aggcggccga gcgcctgggc gagtttgctt acggcaagcg cagccgctcc 16485 gcgccgaagg aagaggcggt gtccatcccg ctggaccacg gcaaccccac gccgagcctc 16545 aagcccgtga ccctgcagca ggtgctgccg accgcggcgc cgcgccgggg gttcaagcgc 16605 gagggcgagg atctgtaccc caccatgcag ctgatggtgc ccaagcgcca gaagctggaa 16665 gacgtgctgg agaccatgaa ggtggacccg gacgtgcagc ccgaggtcaa ggtgcggccc 16725 atcaagcagg tggccccggg cctgggcgtg cagaccgtgg acatcaagat ccccacggag 16785 cccatggaaa cgcagaccga gcccgtgaaa cccagcacca gcaccatgga ggtgcagacg 16845 gatccttgga tgccatcggc tactagccga agaccccggc gcaagtacgg cgcggccagc 16905 ctgctgatgc ccaactacgc gctgcatcct tccatcatcc ccacgccggg ctaccgcggc 16965 acgcgcttct accgcggtca tacaagccgc cgccgcaaga ccaccacccg ccgccgccgt 17025 cgccgcacaa ccgctgctgc atctacccct gccgccctgg tgcggagagt gtaccgccgc 17085 ggccgcgcgc ctctgaccct gccgcgcgcg cgctaccacc cgagcattgc catttaaact 17145 ttcgcctgct ttgcagatca atggccctca catgccgcct ccgcgttccc attacgggct 17205 accgaggaag aaaaccgcgc cgtagaaggc tggcggggaa cgggatgcgt cgccaccacc 17265 accggcggcg gcgcgccatc agcaagcggt tggggggagg cttcctgccc gcgctgatcc 17325 ccatcatcgc cgcggcgatc ggggcgatcc ccggcattgc ttccgtggcg gtgcaggcct 17385 ctcagcgcca ctgagacaca cttggaaaca tcttgtaata aaccaatgga ctctgacgct 17445 cctggtcctg tgatgtgttt tcgtagacag atggaagaca tcaatttttc gtccctggct 17505 ccgcgacacg gcacgcggcc gttcatgggc acctggagcg acatcggcac cagccaactg 17565 aacgggggcg ccttcaattg gagcagtctc tggagcgggc ttaagaattt cgggtccacg 17625 cttaaaacct atggcagcaa ggcgtggaac agcaccacag ggcaggcgct gagggataag 17685 ctgaaagagc agaacttcca gcagaaggtg gtcgatggcc tggcctcggg catcaacggg 17745 gtggtggacc tggccaacca ggccgtgcag cggcagatca acagccgcct ggacccggtg 17805 ccgcccgccg gctccgtgga gatgccgcag gtggaggagg agctgcctcc cctggacaag 17865 cggggcgaga agcgaccccg ccccgacgcg gaggagacgc tgctgacgca cacggacgag 17925 ccgcccccgt acgaggaggc ggtgaaactg ggcctgccca ccacgcggcc catcgcgcct 17985 ctggccaccg gggtgctgaa acccgaaagt agtaagcccg cgaccctgga cttgcctcct 18045 ccccagcctt cccgcccctc cacagtggct aagcctctgc cgccggtggc cgtggcccgc 18105 gcgcgacccg ggggcaccgc ccgccctcat gcgaactggc agagcactct gaacagcatc 18165 gtgggtctgg gagtgcagag tgtgaagcgc cgccgctgct attaaaccta ccgtagcgct 18225 taacttgctt gtctgtgtgt gtatgtatta tgtcgccgcc gctgtcgcca gaaggaggag 18285 tgaagaggcg cgtcgccgag ttgcaagatg gccaccccat cgatgctgcc ccagtgggcg 18345 tacatgcaca tcgccggaca ggacgcttcg gagtacctga gtccgggtct ggtgcagttc 18405 gcccgcgcca cagacaccta cttcagtctg gggaacaagt ttaggaaccc cacggtggcg 18465 cccacgcacg atgtgaccac cgaccgcagc cagcggctga cgctgcgctt cgtgcccgtg 18525 gaccgcgagg acaacaccta ctcgtacaaa gtgcgctaca cgctggccgt gggcgacaac 18585 cgcgtgctgg acatggccag cacctacttt gacatccgcg gcgtgctgga ccggggccct 18645 agcttcaaac cctactccgg caccgcctac aatgctctgg cccccaaggg agcacccaac 18705 acttgccagt ggacatacac agataagcaa accgaaaaaa cagccacgta tgggaatgcg 18765 cctgtacaag gcattgccat cacaaaagat ggtattcaac ttggaactga cagtgatgga 18825 aatcctgtat atgctcaaaa gacatttgaa cccgaacctc aagtgggtga tgcagaatgg 18885 catgacacta caggtacaga tgaaaagtat ggaggcaggg cacttaagcc tgacaccaaa 18945 atgaagcctt gctatggttc ttttgccaaa cccactaaca aagaaggtgg acaggcaaag 19005 aacagaacaa aaactgatgg aactggcgaa gagcctgata ttgatatggc attttttgac 19065 ggcagaaatg caactacagc tggtttggct ccagaaattg ttttgtatac tgagaatgtg 19125 gatctggaga ctccagatac ccatattgta tacaaagcag gcacagatga cagcagctct 19185 tcgattaatt tggggcagca atccatgccc aacagaccca actacattgg gttcagagac 19245 aactttatcg ggctcatgta ctacaacagc actggcaata tgggggtgct ggccggtcag 19305 gcttctcagc tgaatgctgt ggttgacttg caagacagaa acaccgaact gtcctaccag 19365 ctcttgcttg actctctggg cgacagaacc ctgtatttca gtatgtggaa tcaggcggtg 19425 gacagctatg atcctgatgt gcgcattatt gaaaaccatg gtgtggaaga tgaacttccc 19485 aactattgct tccctctgga tgctgttggt aggacagata cttatcaggg aattaagccc 19545 aatggaggcg atccagccac atgggccaaa gatgacagcg ccaatgatgc taatgaaatg 19605 ggcaagggca atccattcgc catggaaatc aacatccaag ccaacctgtg gaggaacttc 19665 ctctacgcca acgtggccct gtacctaccc gattcttaca agtacacgcc ggccaacgtc 19725 accctgccca ccaacaccaa cacctacgat tatatgaacg gccgggtggt ggcgccttcg 19785 ctggtggact cctacatcaa catcggggcg cgctggtcgc tggaccccat ggacaacgtc 19845 aatcccttca accaccaccg caacgcgggc ttgcgctacc gctccatgct cctgggcaac 19905 gggcgctacg tgcccttcca catccaggtg ccccagaaat ttttcgccat caagagcctc 19965 ctgctcctgc ccgggtccta cacctacgag tggaacttcc gcaaggacgt caacatgatc 20025 ctgcagagct ccctcggcaa cgacctgcgc acggacgggg cctccatctc cttcaccagc 20085 atcaacctct acgccacctt cttccccatg gcgcacaaca cggcctccac gctcgaggcc 20145 atgctgcgca acgacaccaa cgaccagtcc ttcaacgact acctctcggc ggccaacatg 20205 ctctacccca tcccggccaa cgccaccaac gtgcccatct ccatcccctc gcgcaactgg 20265 gccgccttcc gcggctggtc cttcacgcgc ctcaagacca aggagacgcc ctcgctgggc 20325 tccgggttcg acccctactt cgtctactcg ggctccatcc cctacctcga cggcaccttc 20385 tacctcaacc acaccttcaa gaaggtctcc atcaccttcg actcctccgt cagctggccc 20445 ggcaacgacc ggctcctgac gcccaacgag ttcgaaatca agcgcaccgt cgacggcgag 20505 ggctacaacg tggcccagtg caacatgacc aaggactggt tcctggtcca gatgctggcc 20565 cactacaaca tcggctacca gggcttctac gtgcccgagg gctacaagga ccgcatgtac 20625 tccttcttcc gcaacttcca gcccatgagc cgccaggtgg tggacgaggt caactacaag 20685 gactaccagg ccgtcaccct ggcctaccag cacaacaact cgggcttcgt cggctacctc 20745 gcgcccacca tgcgccaggg ccagccctac cccgccaact acccgtaccc gctcatcggc 20805 aagagcgccg tcaccagcgt cacccagaaa aagttcctct gcgacagggt catgtggcgc 20865 atccccttct ccagcaactt catgtccatg ggcgcgctca ccgacctcgg ccagaacatg 20925 ctctatgcca actccgccca cgcgctagac atgaatttcg aagtcgaccc catggatgag 20985 tccacccttc tctatgttgt cttcgaagtc ttcgacgtcg tccgagtgca ccagccccac 21045 cgcggcgtca tcgaggccgt ctacctgcgc acccccttct cggccggtaa cgccaccacc 21105 taaattgcta cttgcatgat ggctgaggcc gcgggctccg gcgagcagga gctcagggcc 21165 atcatccgcg acctgggctg cgggccctac ttcctgggca ccttcgataa gcgcttcccg 21225 ggattcatgg ccccgcacaa gctggcctgc gccatcgtca acacggccgg tcgcgagacc 21285 gggggcgagc actggctggc cttcgcctgg aacccgcgct cgaacacctg ctacctcttc 21345 gaccccttcg ggttctcgga cgagcgcctc aagcagatct accagttcga gtacgagggc 21405 ctgctgcgcc gcagcgccct ggccaccgag gaccgctgcg tcaccctgga aaagtccacc 21465 cagaccgtgc agggtccgcg ctcggccgcc tgcgggctct tctgctgcat gttcctgcac 21525 gccttcgtgc actggcccga ccgccccatg gacaagaacc ccaccatgaa cttgctgacg 21585 ggggtgccca acggcatgct ccagtcgccc caggtggaac ccaccctgcg ccgcaaccag 21645 gaggcgctct accgcttcct caactcccac tccgcctact ttcgctccca ccgcgcgcgc 21705 atcgagaagg ccaccgcctt cgatcgcatg aacaatcaag acatgtaaac cgtgtgtgta 21765 tgtttaaaat atcttttaat aaacagcact ttcatgttac acatgcatct gagatgatta 21825 tttagaaatc gaaagggttc tgccgggtct cggcatggcc cgcgggcagg gacacgttgc 21885 ggaactggta cttggccagc cacttgaact cggggatcag cagtttcggc agcggggtgt 21945 cggggaagga gtcggtccac agcttccgcg tcagttgcag ggcgcccagc aggtcgggcg 22005 cggagatctt gaaatcgcag ttgggacccg cgttctgcgc gcgagagttg cggtacacgg 22065 ggttgcagca ctggaacacc atcagggccg ggtgcttcac gctcgccagc accgtcgcgt 22125 cggtgatgct ctccacgtcg aggtcctcgg cgttggccat cccgaagggg gtcatcttgc 22185 aggtctgcct tcccatagtg ggcacgcacc cgggcttgtg gttgcaatcg cagtgcaggg 22245 ggatcagcat catctgggcc tggtcggcgt tcatccccgg gtacatggcc ttcatgaaag 22305 cctccaattg cctgaaagcc tgctgggcct tggctccctc ggtgaagaag accccgcagg 22365 acttgctaga gaactggttg gtagcgcacc cggcgtcgtg cacgcagcag cgcgcgtcgt 22425 tgttggccag ctgcaccacg ctgcgccccc agcggttctg ggtgatcttg gcccggtcgg 22485 ggttctcctt cagcgcgcgc tgcccgttct cgctcgccac atccatctcg atcatgtgct 22545 ccttctggat catggtggtc ccgtgcaggc accgcagctt gccctcggtc tcggtgcacc 22605 cgtgcagcca cagcgcgcac ccggtgcact cccagttctt gtgggcgatc tgggaatgcg 22665 cgtgcacgaa cccctgcagg aagcggccca tcatggtggt cagggtcttg ttgctagtga 22725 aggtcagcgg gatgccgcgg tgctcctcgt tgatgtacag gtggcagatg cggcggtaca 22785 cctcgccctg ctcgggcatc agctggaagt tggctttcag gtcggtctcc acgcggtagc 22845 ggtccatcag tatagtcatg atttccatac ccttctccca ggccgagacg atgggcaggc 22905 tcatagggtt cttcaccatc atcttagcac tagcagccgc ggccaggggg tcgctctcat 22965 ccagggtctc aaagctccgc ttgccgtcct tctcggtgat ccgcaccggg gggtagctga 23025 agcccacggc cgccagctcc tcctcggcct gcctttcgtc ctcgctgtcc tggctgacgt 23085 cctgcaggac cacatgcttg gtcttgcggg gtttcttctt gggcggcagc ggcggcggag 23145 atgcttgtgg cgagggggag cgcgagttct cgctcaccac tactatctct tcctcttcgt 23205 ggtccgaggc cacgcggcgg taggtatgtc tcttcggggg cagaggcgga ggcgacgggc 23265 tctcgccgcc gcgacttggc ggatggctgg cagagcccct tccgcgatcg ggggtgcgct 23325 cccggcggcg ctctgactga cttcctccgc ggccggccat tgtgttctcc tagggaggaa 23385 caacaagcat ggagactcag ccatcgccaa cctcgccatc tgcccccacc accgccgacg 23445 agaagcagca gaatgaaagc ttaaccgccc cgccgcccag ccccgccacc tccgacgcag 23505 ccgcggtccc agacatgcaa gagatggagg aatccatcga gattgacctg ggctatgtga 23565 cgcccgcgga gcacgaggag gagctggcag tgcgctttca atcgtcaagc caggaagata 23625 aagaacagcc agagcaggaa gcagaaaacg agcagagtca ggctgggctc gagcatgacg 23685 gcgactacct ccacctgagc ggggaggagg acgcgctcat caagcatctg gcccggcagg 23745 ccatcatcgt caaggatgcg ctgctcgacc gcaccgaggt gcccctcagc gtggaggagc 23805 tcagccgcgc ctacgagctc aacctcttct cgccgcgcgt gccccccaag cgccagccca 23865 acggcacctg cgagcccaac ccgcgcctca acttctaccc ggtcttcgcg gtgcccgagg 23925 ccctggccac ctaccacatc tttttcaaga accaaaagat ccccgtctcc tgtcgcgcca 23985 accgcacccg cgccgacgcc ctcttcaacc tgggccccgg cgcccgccta cctgatatcg 24045 cctccttgga agaggttccc aagatcttcg agggtctggg cagcgacgag actcgggccg 24105 caaacgctct gcaaggagaa ggaggagagc atgagcacca cagcgccctg gtcgagttgg 24165 aaggcgacaa cgcgcggctg gcggtgctca aacgcacggt cgagctgacc catttcgcct 24225 acccggctct gaacctgccc cccaaagtca tgagcgcggt catggaccag gtgctcatca 24285 agcgcgcgtc gcccatctcc gaggacgagg gcatgcaaga ctccgaggat ggcaagcccg 24345 tggtcagcga cgagcagctg gcccggtggc tgggtcctaa tgctagtccc cagagtttgg 24405 aagagcggcg caagctcatg atggccgtgg tcctggtgac cgtggagctg gagtgcctgc 24465 gccgcttctt cgccgacgcg gagaccctgc gcaaggtcga ggagaacctg cactacctct 24525 tcaggcacgg gttcgtgcgc caggcctgca agatctccaa cgtggagctg accaacctgg 24585 tctcctacat gggcatcttg cacgagaacc gcctggggca gaacgtgctg cacaccaccc 24645 tgcgcgggga ggcccgccgc gactacatcc gcgactgcgt ctacctctac ctctgccaca 24705 cctggcagac gggcatgggc gtgtggcagc agtgtctgga ggagcagaac ctgaaagagc 24765 tctgcaagct cctgcagaag aacctcaagg gtctgtggac cgggttcgac gagcggacca 24825 ccgcctcgga cctggccgac ctcatcttcc ccgagcgcct caggctgacg ctgcgcaacg 24885 gcctgcccga ctttatgagc caaagcatgt tgcaaaactt tcgctctttc atcctcgaac 24945 gctccggaat cctgcccgcc acctgctccg cgctgccctc ggacttcgtg ccgctgacct 25005 tccgcgagtg ccccccgccg ctgtggagcc actgctacct gctgcgcctg gccaactacc 25065 tggcctacca ctcggacgtg atcgaggacg tcagcggcga gggcctgctt gagtgccact 25125 gccgctgcaa cctctgcacg ccgcaccgct ccctggcctg caacccccag ctgctgagcg 25185 agacccagat catcggcacc ttcgagttgc aagggcccag cgatgacggc gagggagcca 25245 aggggggtct gaaactcacc ccggggctgt ggacctcggc ctacttgcgc aagttcgtgc 25305 ccgaggacta ccatcccttc gagatcaggt tctacgagga ccaatcccag ccgcctaagg 25365 ccgagctgtc ggcctgcgtc atcacccagg gggccatcct ggcccaattg caagccatcc 25425 agaaatcccg ccaagaattc ttgctgaaaa agggccgcgg ggtctacctc gacccccaga 25485 ccggtgagga gctcaacccc ggcttccccc agg atg ccc cga gga aac aag aag 25539 Met Pro Arg Gly Asn Lys Lys 505 ctg aaa gtg gag ctg ccg ccc gtg gag gat ttg gag gaa gac tgg gag 25587 Leu Lys Val Glu Leu Pro Pro Val Glu Asp Leu Glu Glu Asp Trp Glu 510 515 520 aac agc agt cag gca gag gag gag atg gag gaa gac tgg gac agc act 25635 Asn Ser Ser Gln Ala Glu Glu Glu Met Glu Glu Asp Trp Asp Ser Thr 525 530 535 cag gca gag gag gac agc ctg caa gac agt ctg gag gaa gac gag gag 25683 Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser Leu Glu Glu Asp Glu Glu 540 545 550 555 gag gca gag gtg gaa gaa gca gcc gcc gcc aga ccg tcg tcc tcg gcg 25731 Glu Ala Glu Val Glu Glu Ala Ala Ala Ala Arg Pro Ser Ser Ser Ala 560 565 570 ggg gag aaa gca agc agc acg gat acc atc tcc gct ccg ggt cgg ggt 25779 Gly Glu Lys Ala Ser Ser Thr Asp Thr Ile Ser Ala Pro Gly Arg Gly 575 580 585 ccc gct cgg ccc cac agt aga tgg gac gag acc ggg cga ttc ccg aac 25827 Pro Ala Arg Pro His Ser Arg Trp Asp Glu Thr Gly Arg Phe Pro Asn 590 595 600 ccc acc atc cag acc ggt aag aag gag cgg cag gga tac aag tcc tgg 25875 Pro Thr Ile Gln Thr Gly Lys Lys Glu Arg Gln Gly Tyr Lys Ser Trp 605 610 615 cgg ggg cac aaa aac gcc atc gtc tcc tgc ttg cag gcc tgc ggg ggc 25923 Arg Gly His Lys Asn Ala Ile Val Ser Cys Leu Gln Ala Cys Gly Gly 620 625 630 635 aac atc tcc ttc acc agg cgc tac ctg ctc ttc cac cgc ggg gtg aac 25971 Asn Ile Ser Phe Thr Arg Arg Tyr Leu Leu Phe His Arg Gly Val Asn 640 645 650 ttc ccc cgc aac atc ttg cat tac tac cgt cac ctc cac agc ccc tac 26019 Phe Pro Arg Asn Ile Leu His Tyr Tyr Arg His Leu His Ser Pro Tyr 655 660 665 tac ttc caa gaa gag gca gca gca gaa aaa gac cag cag aaa acc agc 26067 Tyr Phe Gln Glu Glu Ala Ala Ala Glu Lys Asp Gln Gln Lys Thr Ser 670 675 680 agc tagaaaatcc acagcggcag caggtggact gaggatcgcg gcgaacgagc 26120 Ser cggcgcagac ccgggagctg aggaaccgga tctttcccac cctctatgcc atcttccagc 26180 agagtcgggg gcaggagcag gaactgaaag tcaagaaccg ttctctgcgc tcgctcaccc 26240 gcagttgtct gtatcacaag agcgaagacc aacttcagcg cactctcgag gacgccgagg 26300 ctctcttcaa caagtactgc gcgctcactc ttaaagagta gcccgcgccc gcccagtcgc 26360 agaaaaaggc gggaattacg tcacctgtgc ccttcgccct agccgcctcc acccatcatg 26420 agcaaagaga ttcccacgcc ttacatgtgg agctaccagc cccagatggg cctggccgcc 26480 ggcgccgccc aggactactc cacccgcatg aattggctca gcgccgggcc cgcgatgatc 26540 tcacgggtga atgacatccg cgcccaccga aaccagatac tcctagaaca gtcagcgctc 26600 accgccacgc cccgcaatca cctcaatccg cgtaattggc ccgccgccct ggtgtaccag 26660 gaaattcccc agcccacgac cgtactactt ccgcgagacg cccaggccga agtccagctg 26720 actaactcag gtgtccagct ggcgggcggc gccaccctgt gtcgtcaccg ccccgctcag 26780 ggtataaagc ggctggtgat ccggggcaga ggcacacagc tcaacgacga ggtggtgagc 26840 tcttcgctgg gtctgcgacc tgacggagtc ttccaaatcg ccggatcggg gagatcttcc 26900 ttcacgcctc gtcaggcggt cctgactttg gagagttcgt cctcgcagcc ccgctcgggc 26960 ggcatcggca ctctccagtt cgtggaggag ttcactccct cggtctactt caaccccttc 27020 tccggctccc ccggccacta cccggacgag ttcatcccga actttgacgc catcagcgag 27080 tcggtggacg gctacgattg aatgtcccat ggtggcgcgg ctgacctagc tcggcttcga 27140 cacctggacc actgccgccg ctttcgctgc ttcgctcggg acctcgccga gttcacctac 27200 ttcgagctgc ccgaggagca tcctcagggc ccggcccacg gagtgcggat cgtcgtcgaa 27260 gggggcctag actcccacct gcttcggatc ttcagccagc gcccgatcct ggtcgagcgc 27320 caacagggca acaccctcct gaccctctac tgcatctgcg accaccccgg cctgc atg 27378 Met 685 aaa gtc ttt gtt gtc tgc tgt gta ctg agt ata ata aaa gct gag atc 27426 Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu Ile 690 695 700 agc gac tac tcc gga ctc aac tgt ggt gtt tct gca tcc atc aac cag 27474 Ser Asp Tyr Ser Gly Leu Asn Cys Gly Val Ser Ala Ser Ile Asn Gln 705 710 715 tct ctg acc ttc acc ggg aac gag acc gag ctc cag ctc cag tgt aag 27522 Ser Leu Thr Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys 720 725 730 ccc cac aag aag tac ctc acc tgg ctg tac cag ggc tcc ccg atc gcc 27570 Pro His Lys Lys Tyr Leu Thr Trp Leu Tyr Gln Gly Ser Pro Ile Ala 735 740 745 gtt gtt aac cac tgc gac gac gac gga gtc ctg ctg aac ggc ccc gcc 27618 Val Val Asn His Cys Asp Asp Asp Gly Val Leu Leu Asn Gly Pro Ala 750 755 760 765 aac ctt act ttt tcc acc cgc aga agc aag cta ctg ctc ttc aga ccc 27666 Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Leu Leu Phe Arg Pro 770 775 780 ttc ctc ccc ggg atc tat cag tgc atc tcg gga ccc tgc cat cac acc 27714 Phe Leu Pro Gly Ile Tyr Gln Cys Ile Ser Gly Pro Cys His His Thr 785 790 795 ttc cac ctg atc ccg aat acc acc tct tcc cca gca ccg ctc ccc act 27762 Phe His Leu Ile Pro Asn Thr Thr Ser Ser Pro Ala Pro Leu Pro Thr 800 805 810 aac aac caa act aac cac caa cgc cac cgt cga gac ctt tcc tct gat 27810 Asn Asn Gln Thr Asn His Gln Arg His Arg Arg Asp Leu Ser Ser Asp 815 820 825 tct aat acc act acc gga ggt gag ctc cga ggt act aag aag tcc tca 27858 Ser Asn Thr Thr Thr Gly Gly Glu Leu Arg Gly Thr Lys Lys Ser Ser 830 835 840 845 cct ggg att tat tac ggc ccc tgg gag gtg gtg ggg tta ata gct tta 27906 Pro Gly Ile Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu 850 855 860 ggc tta gta gcg ggt ggg ctt ttg gct ctc tgc tac cta tac ctc cct 27954 Gly Leu Val Ala Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro 865 870 875 tgc tgt tcc tac tta gtg gtg ctt tgt tgc tgg ttt aag aaa tgg gga 28002 Cys Cys Ser Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly 880 885 890 aga tca ccc tagtgtgcgg tgtgctggtg acggtggtgc tttcgattct 28051 Arg Ser Pro 895 gggaggggga agcgcggctg tagtgacgga gaagaaggcc gatccctgct tgactttcaa 28111 tcccgataaa tgccggctga gttttcagcc agatggcaat cggtgcacgg tgctgatcaa 28171 gtgcggatgg gaatgcgaga gcgtggcgat ccagtataaa aacaagacgc ggaacaatac 28231 tctcgcgtcc acatggcagc ccggggaccc cgagtggtac accgtctctg tccctggtgc 28291 tgacggctcc ctccacacgg tgaacaacac tttcattttt gagcacatgt gcgaaaccgc 28351 catgttcatg agcaagcagt acggtatgtg gcccccacga aaagagaata tcgtggtctt 28411 ctccatcgct tacagcgcgt gcacggtgct aatcaccgcg atcgtgtgcc tgagcattca 28471 catgctcatc gctattcgcc ccagaaataa tgccgagaaa gagaaacagc cataacacac 28531 ttttttcaca caccttgttt tttacagaca atgcgtctgt taatttttgt tatcattaca 28591 ctcagcttta actatgccca tggctatgca aatatacaaa aaaccctcta tgtaggctct 28651 gactctacat tagaaggtac tcaatctcaa gccagggttt catggtattt ttataaaggc 28711 tctgatgacc caattactct ttgcaaaggt gatcaggggc gcataacaaa gccacctatc 28771 acatttagct gcaccagaac aaacctcacg cttttatcca ttacaaaaga atatgctggc 28831 acttattaca gcacaaattt tcatcgtggg caagataaat attatactgt taaggtagaa 28891 aaccctacca cccctagaac aactacaaag cccaccacaa ctaagaagcc cactacacct 28951 aagaagccta ccacacccaa aaccactaag acaacaactg ctaagaccac taccacaaag 29011 ccaaccacaa ccagcaccac acttgctata actacacaca cacacactga gctgacctca 29071 caggcaacta ctgaaaatga tttggttgcc ctgttgcaaa agggggagaa cagtagcagc 29131 agtcctctgc ctactacccc cagtgaggaa atacccaagt ccatggttgg cattatcgct 29191 gctgtagtgg tgtgtatgct gattatcatc ttgtgcatga tgtactatgc ctgctactac 29251 agaaaacaca ggctgaacaa caaactggac cccttactga gtgttgattt ttaatttttt 29311 agaaccatga agatcctaag cctttttgtt ttttctataa ttattacctc tgctatttgt 29371 gaatcagtgg ataaggacgt tactgtcacc actggctcta attatacact aaaagggcct 29431 tcctcaggta tgctttcgtg gtattgttat tttggaaatg atgataaaca gacagagcta 29491 tgtaactttc agaacggcaa aaccaaaaat tctaaaatag ataactatca atgccagggt 29551 actaatttag tactgatgaa tatcacgaaa gcatatgctg gcagttattc ctgtcctgga 29611 caaaacaccg aggaaatgat tttttacaaa ttaattgtag ttgaccctac tactccagca 29671 ccacccacca caaccaaggc acataccaca gacacacagg aaaccactcc agaggcagaa 29731 gtagcagagt tagcaaagca gattcatgaa gattcatttg ttgccaatac ccccacacac 29791 cccggaccgc aatgtccagg gccattagtc agcggcattg tcggtgtgct ttgcgggtta 29851 gcagttataa tcatctgcat gttcattttt gcttgctgct acagaaggct tcaccgacaa 29911 aaatcagacc cactgctgaa cctctatgtt taatttttga ttttccagag ccatgaaggc 29971 acttagcact ttagtatttt tgtccttgat tggcattgtt ttcagtgctg ggtttttgaa 30031 aaatcttacc attattgaag gtgataatgc aacactggta ggaatcagcg gtcagaatgt 30091 tagttggcta aaatatcatc tagatgggtg gaaacctatt tgcacctgga atgtcagtgt 30151 gtacacatgc catggtgtta acctcaccat taccaatgcc acccaagatc agaatggcag 30211 gtttaagggt cagagtttca ctagcaacaa tgggtatgaa acccataaca tgttcatcta 30271 tgatgtcact gtcatatcaa ataagactac acctaccaca cagacaccca ctacacatag 30331 ctcaactcat gccatgcaga ccactcagac aaccacatac actacatcta ctgagtccac 30391 caccaccact acagcagagg tatccagcac agcgcctcag ccccaggcat tggctttgat 30451 ggctcagcct agcagcatga ctgctaaaac caatgagcag actactgaat ttttgtccac 30511 tattcagagc agcaccacag ctacctcgag tgccttctct agcaccgcca atctcacctc 30571 gctttcctct acgccaatca gtaacgctac tacctccccc gctcctcttc ccactcctct 30631 gaagcaatcc gagtctagca cgcagctgca gatcaccctg ctcattgtga tcggggtggt 30691 catcctggca gtgctgctct actttatctt ctgccgccgc atccccaacg cgaaaccggc 30751 ctacaagccc attgttatcg ggacgccgga gccgcttcag gtggagggag gtctaaggaa 30811 tcttctcttc tcttttacag tatggtgatt tgaactatga ttcctagaca tttcattatc 30871 acttctctaa tctgtgtgct ccaagtctgt gccaccctcg ctctcgtggc taacgcgagt 30931 ccagactgca ttggagcgtt cgcctcctac gtgctctttg ccttcatcac ctgcatctgc 30991 tgctgtagca tagtctgcct gcttatcacc ttcttccagt tcgttgactg ggtctttgtg 31051 cgcatcgcct acctgcgcca ccacccccag taccgcgacc agagagtggc gcaactgttg 31111 agactcatct gatgataagc atgcgggctc tgctactact tctcgcgctt ctgctagctc 31171 ccctcgccgc ccccctatcc ctcaaatccc ccacccagtc ccctgaagag gttcgaaaat 31231 gtaaattcca agaaccctgg aaattccttt catgctacaa actcaaatca gaaatgcacc 31291 ccagctggat catgatcgtt ggaatcgtaa acatccttgc ctgtaccctc ttctcctttg 31351 tgatttaccc ccgctttgac tttgggtgga acgcacccga ggcgctctgg ctcccgcctg 31411 atcccgacac accaccacag cagcagcaaa atcaggcaca ggcacatgca ccaccacagc 31471 ctaggccaca atacatgccc atcttagact atgaggccga gccacagcga gccatgcttc 31531 ctgctattag ttacttcaat ctaaccggcg gag atg act gac ccc atg gcc aac 31585 Met Thr Asp Pro Met Ala Asn 900 aac acc gtc aac gac ctc ctg gac atg gac ggc cgc gcc tcg gag cag 31633 Asn Thr Val Asn Asp Leu Leu Asp Met Asp Gly Arg Ala Ser Glu Gln 905 910 915 cga ctc gcc caa ctc cgc atc cgc cag cag cag gag aga gcc gtc aag 31681 Arg Leu Ala Gln Leu Arg Ile Arg Gln Gln Gln Glu Arg Ala Val Lys 920 925 930 935 gag ctg cag gac gcg gtg gcc atc cac cag tgc aag aga ggc atc ttc 31729 Glu Leu Gln Asp Ala Val Ala Ile His Gln Cys Lys Arg Gly Ile Phe 940 945 950 tgc ctg gtg aag cag gcc aag atc tcc ttc gag gtc acg tcc acc gac 31777 Cys Leu Val Lys Gln Ala Lys Ile Ser Phe Glu Val Thr Ser Thr Asp 955 960 965 cat cgc ctc tcc tac gag ctc ctg cag cag cgc cag aag ttc acc tgc 31825 His Arg Leu Ser Tyr Glu Leu Leu Gln Gln Arg Gln Lys Phe Thr Cys 970 975 980 ctg gtc gga gtc aac ccc atc gtc atc acc cag cag tct ggc gat acc 31873 Leu Val Gly Val Asn Pro Ile Val Ile Thr Gln Gln Ser Gly Asp Thr 985 990 995 aag ggt tgc atc cac tgc tcc tgc gac tcc ccc gag tgc gtt cac 31918 Lys Gly Cys Ile His Cys Ser Cys Asp Ser Pro Glu Cys Val His 1000 1005 1010 acc ctg atc aag acc ctc tgc ggc ctc cgc gac ctc ctc ccc atg 31963 Thr Leu Ile Lys Thr Leu Cys Gly Leu Arg Asp Leu Leu Pro Met 1015 1020 1025 aac taatcaacta accc 31980 Asn 1030 <210> 98 <211> 500 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 98 Met Glu Ser Arg Asn Pro Phe Gln Gln Gly Leu Pro Ala Gly Phe Leu 1 5 10 15 Ser Ser Ser Phe Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn 20 25 30 Leu Arg Leu Leu Ala Gly Thr Ala Ala Arg His Ser Glu Asp Pro Glu 35 40 45 Ser Pro Gly Glu Ser Gln Gly Thr Pro Thr Ser Pro Ala Ala Ala Ala 50 55 60 Ala Ala Gly Gly Gly Ser Arg Arg Glu Pro Glu Ser Arg Pro Gly Pro 65 70 75 80 Ser Gly Gly Gly Gly Gly Val Ala Asp Leu Phe Pro Glu Leu Arg Arg 85 90 95 Val Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly Ile Lys Arg Glu 100 105 110 Arg His Asp Glu Thr Asn His Arg Thr Glu Leu Thr Val Ser Leu Met 115 120 125 Ser Arg Lys Arg Pro Glu Thr Val Trp Trp His Glu Val Gln Ser Thr 130 135 140 Gly Thr Asp Glu Val Ser Val Met His Glu Lys Phe Ser Leu Glu Gln 145 150 155 160 Val Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp Glu Val Ala Ile 165 170 175 Arg Asn Tyr Ala Lys Leu Ala Leu Met Pro Asp Lys Lys Tyr Lys Ile 180 185 190 Thr Lys Leu Ile Asn Ile Arg Asn Ala Cys Tyr Ile Ser Gly Asn Gly 195 200 205 Ala Glu Val Glu Ile Cys Leu Gln Asp Arg Val Ala Phe Arg Cys Cys 210 215 220 Met Met Asn Met Tyr Pro Gly Val Val Gly Met Asp Gly Val Thr Phe 225 230 235 240 Met Asn Met Arg Phe Arg Gly Asp Gly Tyr Asn Gly Thr Val Phe Met 245 250 255 Ala Asn Thr Lys Leu Thr Val His Gly Cys Ser Phe Phe Gly Phe Asn 260 265 270 Asn Thr Cys Ile Glu Ala Trp Gly Gln Val Gly Val Arg Gly Cys Ser 275 280 285 Phe Ser Ala Asn Trp Met Gly Val Val Gly Arg Thr Lys Ser Met Leu 290 295 300 Ser Val Lys Lys Cys Leu Phe Glu Arg Cys His Leu Gly Val Met Ser 305 310 315 320 Glu Gly Glu Ala Arg Ile Arg His Cys Ala Ser Thr Glu Thr Gly Cys 325 330 335 Phe Val Leu Cys Lys Gly Asn Ala Lys Ile Lys His Asn Met Ile Cys 340 345 350 Gly Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr Cys Ala Gly Gly 355 360 365 Asn Ser His Met Leu Ala Thr Val His Val Ala Ser His Ala Arg Lys 370 375 380 Pro Trp Pro Glu Phe Glu His Asn Val Met Thr Arg Cys Asn Met His 385 390 395 400 Leu Gly Ser Arg Arg Gly Met Phe Met Pro Tyr Gln Cys Asn Leu Asn 405 410 415 Tyr Val Lys Val Leu Leu Glu Pro Asp Ala Met Ser Arg Val Ser Leu 420 425 430 Thr Gly Val Phe Asp Met Asn Val Glu Val Trp Lys Ile Leu Arg Tyr 435 440 445 Asp Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys Gly Gly Lys His 450 455 460 Ala Arg Phe Gln Pro Val Cys Val Asp Val Thr Glu Asp Leu Arg Pro 465 470 475 480 Asp His Leu Val Leu Ser Cys Thr Gly Thr Glu Phe Gly Ser Ser Gly 485 490 495 Glu Glu Ser Asp 500 <210> 99 <211> 184 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 99 Met Pro Arg Gly Asn Lys Lys Leu Lys Val Glu Leu Pro Pro Val Glu 1 5 10 15 Asp Leu Glu Glu Asp Trp Glu Asn Ser Ser Gln Ala Glu Glu Glu Met 20 25 30 Glu Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp 35 40 45 Ser Leu Glu Glu Asp Glu Glu Glu Ala Glu Val Glu Glu Ala Ala Ala 50 55 60 Ala Arg Pro Ser Ser Ser Ala Gly Glu Lys Ala Ser Ser Thr Asp Thr 65 70 75 80 Ile Ser Ala Pro Gly Arg Gly Pro Ala Arg Pro His Ser Arg Trp Asp 85 90 95 Glu Thr Gly Arg Phe Pro Asn Pro Thr Ile Gln Thr Gly Lys Lys Glu 100 105 110 Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser 115 120 125 Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu 130 135 140 Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr 145 150 155 160 Arg His Leu His Ser Pro Tyr Tyr Phe Gln Glu Glu Ala Ala Ala Glu 165 170 175 Lys Asp Gln Gln Lys Thr Ser Ser 180 <210> 100 <211> 212 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 100 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Asn Cys Gly Val Ser Ala Ser Ile Asn 20 25 30 Gln Ser Leu Thr Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys 35 40 45 Lys Pro His Lys Lys Tyr Leu Thr Trp Leu Tyr Gln Gly Ser Pro Ile 50 55 60 Ala Val Val Asn His Cys Asp Asp Asp Gly Val Leu Leu Asn Gly Pro 65 70 75 80 Ala Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Leu Leu Phe Arg 85 90 95 Pro Phe Leu Pro Gly Ile Tyr Gln Cys Ile Ser Gly Pro Cys His His 100 105 110 Thr Phe His Leu Ile Pro Asn Thr Thr Ser Ser Pro Ala Pro Leu Pro 115 120 125 Thr Asn Asn Gln Thr Asn His Gln Arg His Arg Arg Asp Leu Ser Ser 130 135 140 Asp Ser Asn Thr Thr Thr Gly Gly Glu Leu Arg Gly Thr Lys Lys Ser 145 150 155 160 Ser Pro Gly Ile Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala 165 170 175 Leu Gly Leu Val Ala Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu 180 185 190 Pro Cys Cys Ser Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp 195 200 205 Gly Arg Ser Pro 210 <210> 101 <211> 134 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 101 Met Thr Asp Pro Met Ala Asn Asn Thr Val Asn Asp Leu Leu Asp Met 1 5 10 15 Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg Gln 20 25 30 Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Ala Val Ala Ile His 35 40 45 Gln Cys Lys Arg Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile Ser 50 55 60 Phe Glu Val Thr Ser Thr Asp His Arg Leu Ser Tyr Glu Leu Leu Gln 65 70 75 80 Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val Ile 85 90 95 Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys Asp 100 105 110 Ser Pro Glu Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu Arg 115 120 125 Asp Leu Leu Pro Met Asn 130 <210> 102 <211> 1440 <212> DNA <213> Unknown <220> <223> Simian adenovirus A1337 <220> <221> CDS <222> (576)..(1151) <223> E1a <220> <221> CDS <222> (1236)..(1439) <223> E1a <400> 102 catcatcaat aatatacctc aaactttttg tgcgcgttaa tatgcaaatg aggcgtttga 60 atttgggaag ggaggaaggt gattggccga gagaagggcg accgttaggg gcggggcgag 120 tgacgttttg atgacgtggc cgcgaggagg agccagtttg caagttctcg tgggaaaagt 180 gacgtcaaac gaggtgtggt ttgaacacgg aaatactcaa ttttcccgcg ctctctgaca 240 ggaaatgagg tgtttttggg cggatgcaag ttaaaacggg ccattttcgc gcgaaaactg 300 aatgaggaag tgaaaatctg agtaatttcg cgtttatggc agggaggagt atttgccgag 360 ggccgagtag actttgaccg attacgtggg ggtttcgatt accgtgtttt tcacctaaat 420 ttccgcgtac ggtgtcaaag tccggtgttt ttacgtaggt gtcagctgat cgccagggta 480 tttaaacctg cgctctccag tcaagaggcc actcttgagt gccagcgaga agagttttct 540 cctccgcgcc gcgagtcaga tctacacttt gaaag atg agg cac ctg aga gac 593 Met Arg His Leu Arg Asp 1 5 ctg ccc gat gag aaa atc atc atc gct tcc ggg aac gag att ctg gaa 641 Leu Pro Asp Glu Lys Ile Ile Ile Ala Ser Gly Asn Glu Ile Leu Glu 10 15 20 ctg gtg gta aat gcc atg atg ggc gac gac cct ccg gag ccc ccc acc 689 Leu Val Val Asn Ala Met Met Gly Asp Asp Pro Pro Glu Pro Pro Thr 25 30 35 cca ttt gag gta cct tcg cta cac gat ttg tat gat ctg gag gtg gat 737 Pro Phe Glu Val Pro Ser Leu His Asp Leu Tyr Asp Leu Glu Val Asp 40 45 50 gtg ccc gag gac gac ccc aac gag gag gcg gta aat gat tta ttt agc 785 Val Pro Glu Asp Asp Pro Asn Glu Glu Ala Val Asn Asp Leu Phe Ser 55 60 65 70 gat gcc gcg ctg cta gct gcc gag gag gct tcg agc cct agc tca gac 833 Asp Ala Ala Leu Leu Ala Ala Glu Glu Ala Ser Ser Pro Ser Ser Asp 75 80 85 agc gac tct tca ctg cat acc cct aga ccc ggc aga ggt gag aaa aag 881 Ser Asp Ser Ser Leu His Thr Pro Arg Pro Gly Arg Gly Glu Lys Lys 90 95 100 atc ccc gag ctt aaa ggg gaa gag atg gac ttg cgc tgc tat gag gaa 929 Ile Pro Glu Leu Lys Gly Glu Glu Met Asp Leu Arg Cys Tyr Glu Glu 105 110 115 tgc ttg ccc ccg agc gat gat gag gac gag cag gcg atc cag aac gca 977 Cys Leu Pro Pro Ser Asp Asp Glu Asp Glu Gln Ala Ile Gln Asn Ala 120 125 130 gcg agc cag gga gtg caa gcc gcc agc gag agc ttt gcg ctg gac tgc 1025 Ala Ser Gln Gly Val Gln Ala Ala Ser Glu Ser Phe Ala Leu Asp Cys 135 140 145 150 ccg cct ctg ccc gga cac ggc tgt aag tct tgt gaa ttt cat cgc atg 1073 Pro Pro Leu Pro Gly His Gly Cys Lys Ser Cys Glu Phe His Arg Met 155 160 165 aat act gga gat aaa gct gtg tta tgt gca ctt tgc tat atg aga gct 1121 Asn Thr Gly Asp Lys Ala Val Leu Cys Ala Leu Cys Tyr Met Arg Ala 170 175 180 tac aac cat tgt gtt tac agt aag tgt gat taagttgaac tttagaggga 1171 Tyr Asn His Cys Val Tyr Ser Lys Cys Asp 185 190 ggcagagagc agggtgactg ggcgatgact ggtttattta tgtatatatg ttctttatat 1231 aggt ccc gtc tct gac gca gat gat gag acc ccc act aca gag tcc act 1280 Pro Val Ser Asp Ala Asp Asp Glu Thr Pro Thr Thr Glu Ser Thr 195 200 205 tcg tca ccc cca gaa att ggc aca tct cca cct gag aat att gtt aga 1328 Ser Ser Pro Pro Glu Ile Gly Thr Ser Pro Pro Glu Asn Ile Val Arg 210 215 220 cca gtt cct gtt aga gcc act ggg agg aga gca gct gtg gaa tgt ttg 1376 Pro Val Pro Val Arg Ala Thr Gly Arg Arg Ala Ala Val Glu Cys Leu 225 230 235 gat gac ttg cta cag ggt ggg gat gaa cct ttg gac ttg tgt acc cgg 1424 Asp Asp Leu Leu Gln Gly Gly Asp Glu Pro Leu Asp Leu Cys Thr Arg 240 245 250 255 aaa cgc ccc agg cac t 1440 Lys Arg Pro Arg His 260 <210> 103 <211> 260 <212> PRT <213> Unknown <220> <223> Synthetic Construct <400> 103 Met Arg His Leu Arg Asp Leu Pro Asp Glu Lys Ile Ile Ile Ala Ser 1 5 10 15 Gly Asn Glu Ile Leu Glu Leu Val Val Asn Ala Met Met Gly Asp Asp 20 25 30 Pro Pro Glu Pro Pro Thr Pro Phe Glu Val Pro Ser Leu His Asp Leu 35 40 45 Tyr Asp Leu Glu Val Asp Val Pro Glu Asp Asp Pro Asn Glu Glu Ala 50 55 60 Val Asn Asp Leu Phe Ser Asp Ala Ala Leu Leu Ala Ala Glu Glu Ala 65 70 75 80 Ser Ser Pro Ser Ser Asp Ser Asp Ser Ser Leu His Thr Pro Arg Pro 85 90 95 Gly Arg Gly Glu Lys Lys Ile Pro Glu Leu Lys Gly Glu Glu Met Asp 100 105 110 Leu Arg Cys Tyr Glu Glu Cys Leu Pro Pro Ser Asp Asp Glu Asp Glu 115 120 125 Gln Ala Ile Gln Asn Ala Ala Ser Gln Gly Val Gln Ala Ala Ser Glu 130 135 140 Ser Phe Ala Leu Asp Cys Pro Pro Leu Pro Gly His Gly Cys Lys Ser 145 150 155 160 Cys Glu Phe His Arg Met Asn Thr Gly Asp Lys Ala Val Leu Cys Ala 165 170 175 Leu Cys Tyr Met Arg Ala Tyr Asn His Cys Val Tyr Ser Lys Cys Asp 180 185 190 Pro Val Ser Asp Ala Asp Asp Glu Thr Pro Thr Thr Glu Ser Thr Ser 195 200 205 Ser Pro Pro Glu Ile Gly Thr Ser Pro Pro Glu Asn Ile Val Arg Pro 210 215 220 Val Pro Val Arg Ala Thr Gly Arg Arg Ala Ala Val Glu Cys Leu Asp 225 230 235 240 Asp Leu Leu Gln Gly Gly Asp Glu Pro Leu Asp Leu Cys Thr Arg Lys 245 250 255 Arg Pro Arg His 260 <210> 104 <211> 38561 <212> DNA <213> Artificial Sequence <220> <223> Simian adenovirus A1302 clone <220> <221> misc_feature <222> (1030)..(2651) <223> IVa2 complement (1030..2360,2640..2651) <220> <221> misc_feature <222> (2640)..(10880) <223> pol complement (2640..5699,10872..10880) <220> <221> misc_feature <222> (3530)..(3530) <223> is c or g <220> <221> misc_feature <222> (5607)..(10880) <223> pTP complement (5607..7438,10872..10880) <220> <221> CDS <222> (7875)..(9053) <223> 52K <220> <221> CDS <222> (9080)..(10837) <223> pIIIa <220> <221> CDS <222> (10920)..(12503) <223> penton <220> <221> CDS <222> (12510)..(13091) <223> pVII <220> <221> CDS <222> (13139)..(14170) <223> V <220> <221> CDS <222> (14196)..(14426) <223> pX <220> <221> CDS <222> (14498)..(15220) <223> pVI <220> <221> CDS <222> (15264)..(18113) <223> hexon <220> <221> CDS <222> (18132)..(18758) <223> protease <220> <221> misc_feature <222> (18843)..(20375) <223> DBP complement (18843..20375) <220> <221> CDS <222> (20401)..(22791) <223> 100K <220> <221> misc_feature <222> (22767)..(22767) <223> is a or g <220> <221> CDS <222> (23414)..(24094) <223> pVIII <220> <221> CDS <222> (24098)..(24415) <223> E3\12.5K <220> <221> CDS <222> (24977)..(25504) <223> E3\gp19K <220> <221> CDS <222> (25537)..(26130) <223> E3\CR1-beta <220> <221> CDS <222> (26772)..(27644) <223> E3\CR1-delta <220> <221> CDS <222> (27936)..(28364) <223> E3\RID-beta <220> <221> CDS <222> (29061)..(30380) <223> fiber <220> <221> misc_feature <222> (29549)..(29549) <223> is a or c <220> <221> misc_feature <222> (30478)..(31811) <223> E4\orf6/7 complement (30478..30728,31461..31811) <220> <221> misc_feature <222> (30729)..(31631) <223> E4\orf6 complement (30729..31631) <220> <221> misc_feature <222> (31540)..(31902) <223> E4\orf4 complement (31540..31902) <220> <221> misc_feature <222> (31915)..(32265) <223> E4\orf3 complement (31915..32265) <220> <221> rep_origin <222> (33737)..(33737) <223> ORI <220> <221> misc_feature <222> (34495)..(35358) <223> AP(R) complement (34495..35358) <220> <221> repeat_region <222> (35583)..(35705) <223> ITR <220> <221> enhancer <222> (36444)..(36704) <223> Enhancer <220> <221> misc_feature <222> (36705)..(36932) <223> CMV\promoter <220> <221> TATA_signal <222> (36906)..(36909) <223> TATA <220> <221> CDS <222> (37028)..(38119) <223> Gag\short <220> <221> polyA_signal <222> (38272)..(38474) <223> BGH-PolyA <220> <221> misc_feature <222> (38561)..(38561) <223> PI-Scel recognition sequence <400> 104 ggagaaagag gtaatgaaat ggcattatgg gtattatggg tctgcattaa tgaatcggcc 60 agatatcata tgctggccac cgtgcatgtg gcctcgcacc cccgcaagac atggcccgag 120 ttcgagcata acgtcatgac ccgctgcaat gtgcacctgg gctcccgccg aggcatgttc 180 atgccctacc agtgcaacat gcaatttgtg aaggtgctgc tggagcccga tgccatgtcc 240 agagtgagtc tgacgggggt gtttgacatg aatgtggaga tgtggaaaat tctgagatat 300 gatgaatcca agaccaggtg ccgggcctgc gaatgcggag gcaaacacgc caggcttcag 360 cccgtgtgtg tggaggtgac ggaggacctg cgacccgatc atttggtgtt gtcctgcaac 420 gggacggagt tcggctccag cggggaagaa tctgactaga gtgagtagtg tttggggctg 480 ggtgggagcc tgcatgatgg gcagaatgac taaaatctgt gtttttctgc gcagcatcat 540 gagcggaagc gcctcctttg agggaggggt attcagccct tatctgacgg ggcgtctccc 600 ctcctgggcg ggagtgcgtc agaatgtgat gggatccacg gtggacggcc ggcccgtgca 660 gcccgcgaac tcttcaaccc tgacctacgc gaccctgagc tcctcgtccg tagacgcagc 720 tgccgccgca gctgctgctt ccgccgccag cgccgtgcgc ggaatggccc tgggcgccgg 780 ctactacagc tctctggtgg ccaactcgag ttccaccaat aatcccgcca gcctgaacga 840 ggagaagctg ctgctgctga tggcccagct cgaggccctg acccagcgcc tgggcgagct 900 gacccagcag gtggctcagc tgcaggcgga gacgcgggcc gcggttgcca cggtgaaaac 960 caaataaaaa atgaatcaat aaataaacgg agacggttgt tgattttaac acagagtctt 1020 gaatctttat ttgatttttc gcgcgcggta ggccctggac caccggtctc gatcattgag 1080 cacccggtgg attttttcca ggacccggta gaggtgggct tggatgttga ggtacatggg 1140 catgagcccg tcccgggggt ggaggtagct ccattgcagg gcctcgtgct cgggggtggt 1200 gttgtaaatc acccagtcat agcaggggcg cagggcgtgg tgctgcacga tgtccttgag 1260 gaggagactg atggccacgg gcagcccctt ggtgtaggtg ttgacgaacc tgttgagctg 1320 ggagggatgc atgcgggggg agatgagatg catcttggcc tggatcttga gattggcgat 1380 gttcccgccc agatcccgcc gggggttcat gttgtgcagg accaccagca cggtgtatcc 1440 ggtgcacttg gggaatttgt catgcaactt ggaagggaag gcgtgaaaga atttggagac 1500 gcccttgtga ccgcccaggt tttccatgca ctcatccatg atgatggcga tgggcccgtg 1560 ggcggcggcc tgggcaaaga cgtttcgggg gtcggacaca tcgtagttgt ggtcctgggt 1620 gagctcgtca taggccattt taatgaattt ggggcggagg gtgcccgact gggggacaaa 1680 ggtgccctcg atcccggggg cgtagtttcc ctcgcagatc tgcatctccc aggccttgag 1740 ctcggagggg gggatcatgt ccacctgcgg ggcgatgaaa aaaacggttt ccggggcggg 1800 ggagatgagc tgggccgaaa gcaggttccg gagcagctgg gacttgccgc agccggtggg 1860 gccgtagatg accccgatga ccggctgcag gtggtagttg agggagagac agctgccgtc 1920 ctcgcggagg aggggggcca cctcgttcat catctcgcgc acatgcatgt tctcgcgcac 1980 gagttccgcc aggaggcgct cgccccccag cgagaggagc tcttgcagcg aggcgaagtt 2040 tttcagcggt ttgagcccgt cggccatggg cattttggag agggtctgtt gcaagagttc 2100 cagacggtcc cagagctcgg tgatgtgctc tagggcatct cgatccagca gacctcctcg 2160 tttcgcgggt tggggcgact gcgggagtag ggcaccaggc gatgggcgtc cagcgaggcc 2220 agggtccggt ccttccaggg gcgcagggtc cgcgtcagcg tggtctccgt cacggtgaag 2280 gggtgcgcgc cgggctgggc gcttgcgagg gtgcgcttca ggctcatccg gctggtcgag 2340 aaccgctccc ggtcggcgcc ctgcgcgtcg gccaggtagc aattgagcat gagttcgtag 2400 ttgagcgcct cggccgcgtg gcccttggcg cggagcttac ctttggaagt gtgtccgcag 2460 acgggacaga ggagggactt gagggcgtag agcttggggg cgaggaagac ggactcgggg 2520 gcgtaggcgt ccgcgccgca gctggcgcag acggtctcgc actccacgag ccaggtgagg 2580 tcggggcggt cggggtcaaa aacgaggttt cctccgtgct ttttgatgcg tttcttacct 2640 ctggtctcca tgagctcgtg tccccgctgg gtgacaaaga ggctgtccgt gtccccgtag 2700 accgacttta tgggccggtc ctcgagcggg gtgccgcggt cctcgtcgta gaggaacccc 2760 gcccactccg agacgaaggc ccgggtccag gccagcacga aggaggccac gtgggagggg 2820 tagcggtcgt tgtccaccag cgggtccacc ttctccaggg tatgcaagca catgtccccc 2880 tcgtccacat ccaggaaggt gattggcttg taagtgtagg ccacgtgacc gggggtcccg 2940 gccggggggg tataaaaggg ggcgggcccc tgctcgtcct cactgtcttc cggatcgctg 3000 tccaggagcg ccagctgttg gggtaggtat tccctctcga aggcgggcat gacctcggca 3060 ctcaggttgt cagtttctag aaacgaggag gatttgatat tgacggtgcc gttggagacg 3120 cctttcatga gcccctcgtc catctggtca gaaaagacga tctttttgtt gtcgagcttg 3180 gtggcgaagg agccgtagag ggcattggag aggagcttgg cgatggagcg catggtctgg 3240 ttcttttcct tgtcggcgcg ctccttggcg gcgatgttga gctgcacgta ctcgcgcgcc 3300 acgcacttcc attcggggaa gacggtggtg agctcgtcgg gcacgattct gacccgccag 3360 ccgcggttgt gcagggtgat gaggtccacg ctggtggcca cctcgccgcg caggggctcg 3420 ttggtccagc agaggcgccc gcccttgcgc gagcagaagg ggggcagcgg gtccagcatg 3480 agctcgtcgg gggggtcggc gtccacggtg aagatgccgg gcaggagctc ggggtcgaag 3540 tagctgatgc aggtgcccag atcgtccagc gccgcttgcc agtcgcgcac ggccagcgcg 3600 cgctcgtagg ggctgagggg cgtgccccag ggcatggggt gcgtgagcgc ggaggcgtac 3660 atgccgcaga tgtcgtagac gtagaggggc tcctcgagga cgccgatgta ggtggggtag 3720 cagcgccccc cgcggatgct ggcgcgcacg tagtcgtaca gctcgtgcga gggcgcgagg 3780 agccccgcgc cgaggttgga gcgctgcggc ttttcggcgc ggtagacgat ctggcggaag 3840 atggcgtggg agttggagga gatggtgggc ctctggaaga tgttgaagtg ggcgtggggc 3900 aggccgaccg agtccctgat gaagtgggcg taggagtcct gcagcttggc gacgagctcg 3960 gcggtgacga ggacgtccag ggcgcagtag tcgagggtct cttggatgat gtcgtacttg 4020 agctggccct tctgcttcca cagctcgcgg ttgagaagga actcttcgcg gtccttccag 4080 tactcttcga gggggaaccc gtcctgatcg gcacggtaag agcccaccat gtagaactgg 4140 ttgacggcct tgtaggcgca gcagcccttc tccacgggga gggcataagc ttgcgcggcc 4200 ttgcgcaggg aggtgtgggt gagggcgaag gtgtcgcgca ccatgacctt gaggaactgg 4260 tgcttgaagt cgaggtcgtc gcagccgccc tgctcccaga gttggaagtc cgtgcgcttc 4320 ttgtaggcgg ggttgggcaa agcgaaagta acatcgttga agaggatctt gcccgcgcgg 4380 ggcatgaagt tgcgagtgat gcggaaaggc tggggcacct cggcccggtt gttgatgacc 4440 tgggcggcga ggacgatctc gtcgaagccg ttgatgttgt gcccgacgat gtagagttcc 4500 acgaatcgcg ggcggccctt gacgtggggc agcttcttga gctcgtcgta ggtgagctcg 4560 gcggggtcgc tgagtccgtg ctgctcaagg gcccagtcgg cgacgtgggg gttggcgctg 4620 aggaaggaag tccagagatc cacggccagg gcggtttgca agcggtcccg gtactgacgg 4680 aactgctggc ccacggccat tttttcgggg gtgatgcagt agaaggtgcg ggggtcgccg 4740 tgccagcggt cccacttgag ctggagggcg aggtcgtggg cgagctcgac gagcggcggg 4800 tccccggaga gtttcatgac cagcatgaag gggacgagct gcttgccgaa ggaccccatc 4860 caggtgtagg tttccacatc gtaggtgagg aagagccttt cggtgcgagg atgcgagccg 4920 atggggaaga actggatctc ctgccaccag ttggaggaat ggctgttgat gtgatggaag 4980 tagaaatgcc gacggcgcgc cgagcactcg tgcttgtgtt tatacaagcg tccgcagtgc 5040 tcgcaacgct gcacgggatg cacgtgctgc acgagctgta cctgagttcc tttgacgagg 5100 aatttcagtg ggcagtggag cgctggcggc tgcatctggt gctgtactac gtcctggcca 5160 tcggcgtggc catcgtctgc ctcgatggtg gtcatgctga cgagcccgcg cgggaggcag 5220 gtccagacct cgactcggac gggtcggaga gcgaggacga gggcgcgcag gccggagctg 5280 tccagggtcc tgagacgctg cggagtcagg tcagtgggca gcggcggcgc gcggttgact 5340 tgcaggagct tttccagggc gcgcgggagg tccagatggt acttgatctc cacggcgccg 5400 ttggtggcga cgtccacggc ttgcagggtc ccgtgcccct ggggcgccac caccgtgccc 5460 cgtttcttct tgggcgctgg cgttggcgct gcttccatgt cggtcagaag cggcggcgag 5520 gacgcgcgcc gggcggcagg ggcggctcgg ggcccggagg caggggcggc aggggcacgt 5580 cggcgccgcg cgcgggcagg ttctggtact gcgcccggag aagactggcg tgagcgacga 5640 cgcgacggtt gacgtcctgg atctgacgcc tctgggtgaa ggccacggga cccgtgagtt 5700 tgaacctgaa agagagttcg acagaatcaa tctcggtatc gttgacggcg gcctgccgca 5760 ggatctcttg cacgtcgccc gagttgtcct ggtaggcgat ctcggtcatg aactgctcga 5820 tctcctcctc ctgaaggtct ccgcggccgg cgcgctccac ggtggccgcg aggtcgttgg 5880 agatgcggcc catgagctgc gagaaggcgt tcatgcccgc ctcgttccag acgcggctgt 5940 agaccacgac gccctcggga tcgcgggcgc gcatgaccac ctgggcgagg ttgagctcca 6000 cgtggcgcgt gaagaccgcg tagttgcaga ggcgctggta gaggtagttg agcgtggtgg 6060 cgatgtgctc ggtgacgaag aaatacatga tccagcggcg gagcggcatc tcgctgacgt 6120 cgcccagcgc ctccaagcgt tccatggcct cgtaaaagtc cacggcgaag ttgaaaaact 6180 gggagttgcg cgccgagacg gtcaactcct cctccagaag acggatgagc tcggcgatgg 6240 tggcgcgcac ctcgcgctcg aaggcccccg ggagttcctc cacttcctct tcttcttcct 6300 cctccactaa catctcttct acttcctcct caggcggtgg tggcggggga gggggcctgc 6360 gtcgccggcg gcgcacgggc agacggtcga tgaagcgctc gatggtctcg ccgcgccggc 6420 gtcgcatggt ctcggtgacg gcgcgcccgt cctcgcgggg ccgcagcgtg aagacgccgc 6480 cgcgcatctc caggtggccg ggggggtccc cgttgggcag ggagagggcg ctgacgatgc 6540 atcttatcaa ttgccccgta gggactccgc gcaaggacct gagcgtctcg agatccacgg 6600 gatctgaaaa ccgttgaacg aaggcttcga gccagtcgca gtcgcaaggt aggctgagca 6660 cggtttcttc tggcgggtca tgttggttgg agggagcggg gcgggcgatg ctgctggtga 6720 tgaagttgaa ataggcggtt ctgagacggc ggatggtggc gaggagcacc aggtctttgg 6780 gcccggcttg ctggatgcgc agacggtcgg ccatgcccca ggcgtggtcc tgacacctgg 6840 ccaggtcctt gtagtagtcc tgcatgagcc gctccacggg cacctcctcc tcgcccgcgc 6900 ggccgtgcat gcgcgtgagc ccgaacccgc gctgcggctg gacgagcgcc aggtcggcga 6960 cgacgcgctc ggcgaggatg gcctgctgga tctgggtgag ggtggtctgg aagtcgtcaa 7020 agtcgacgaa gcggtggtag gctccggtgt tgatggtgta ggagcagttg gccatgacgg 7080 accagttgac ggtctggtgg cccggacgca cgagctcgtg gtacttgagg cgcgagtagg 7140 cgcgcgtgtc gaagatgtag tcgttgcagg tgcgcaccag gtattggtag ccgatgagga 7200 agtgcggcgg cggctggcgg tagagcggcc atcgctcggt ggcgggggcg ccgggcgcga 7260 ggtcctcgag catgaggcgg tggtagccgt agatgtacct ggacatccag gtgatgccgg 7320 cggcggtggt ggaggcgcgc gggaactcgc ggacgcggtt ccagatgttg cgcagcggca 7380 ggaagtagtt catggtggcc gcggtctggc ccgtgaggcg cgcgcagtcg tggatgctct 7440 agacatacgg gcaaaaacga aagcggtcag cggctcgact ccgtggcctg gaggctaagc 7500 gaacgggttg ggctgcgcgt gtaccccggt tcgaatctcg aatcaggctg gagccgcagc 7560 taacgtggta ctggcactcc cgtctcgacc caagcctgct aacgaaacct ccaggatacg 7620 gaggcgggtc gttttggcat ttttcgtcag gccggaaatg aaactagtaa gcgcggaaag 7680 cggccgaccg cgatggctcg ctgccgtagt ctggagaaga atcgccaggg ttgcgttgcg 7740 gtgtgccccg gttcgaggcc ggccggattc cgcggctaac gagggcgtgg ctgccccgtc 7800 gtttccaaga cccctagcca gccgacttct ccagttacgg agcgagcccc tcttttgttt 7860 tttgtttttg ccag atg cat ccc gta ctg cgg cag atg cgc ccc cac cac 7910 Met His Pro Val Leu Arg Gln Met Arg Pro His His 1 5 10 cct cca ccg caa caa cag ccc cct cca cag ccg gcg ctt ctg ccc ccg 7958 Pro Pro Pro Gln Gln Gln Pro Pro Pro Gln Pro Ala Leu Leu Pro Pro 15 20 25 ccc cag cag cag cag caa ctt cca gcc acg acc gcc gcg gcc gcc gtg 8006 Pro Gln Gln Gln Gln Gln Leu Pro Ala Thr Thr Ala Ala Ala Ala Val 30 35 40 agc ggg gct gga cag agt tat gac cac cag ctg gcc ttg gaa gag ggc 8054 Ser Gly Ala Gly Gln Ser Tyr Asp His Gln Leu Ala Leu Glu Glu Gly 45 50 55 60 gag ggg ctg gcg cgg ctg ggg gcg tcg tcg ccg gag cgg cac ccg cgc 8102 Glu Gly Leu Ala Arg Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg 65 70 75 gtg cag atg aaa agg gac gct cgc gag gcc tac gtg ccc aag cag aac 8150 Val Gln Met Lys Arg Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn 80 85 90 ctg ttc aga gac agg agc ggc gag gag ccc gag gag atg cgc gcc tcc 8198 Leu Phe Arg Asp Arg Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ser 95 100 105 cgc ttc cac gcg ggg cgg gag ctg cgg cgc ggc ctg gac cga aag cgg 8246 Arg Phe His Ala Gly Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg 110 115 120 gtg ctg agg gac gag gat ttc gag gcg gac gag ctg acg ggg atc agc 8294 Val Leu Arg Asp Glu Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser 125 130 135 140 ccc gcg cgc gcg cac gtg gcc gcg gcc aac ctg gtc acg gcg tac gag 8342 Pro Ala Arg Ala His Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu 145 150 155 cag acc gtg aag gag gag agc aac ttc caa aaa tcc ttc aac aac cac 8390 Gln Thr Val Lys Glu Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His 160 165 170 gtg cgc acc ttg atc gcg cgc gag gag gtg acc ctg ggc ctg atg cac 8438 Val Arg Thr Leu Ile Ala Arg Glu Glu Val Thr Leu Gly Leu Met His 175 180 185 ctg tgg gac ctg ctg gag gcc atc gtg cag aac ccc acg agc aag ccg 8486 Leu Trp Asp Leu Leu Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro 190 195 200 ctg acg gcg cag ctg ttt ctg gtg gtg cag cac agt cgg gac aac gag 8534 Leu Thr Ala Gln Leu Phe Leu Val Val Gln His Ser Arg Asp Asn Glu 205 210 215 220 acg ttc agg gag gcg ctg ctg aat atc acc gag ccc gag ggc cgt tgg 8582 Thr Phe Arg Glu Ala Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp 225 230 235 ctc ctg gac ctg gtg aac att ctg cag agc atc gtg gtg cag gag cgc 8630 Leu Leu Asp Leu Val Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg 240 245 250 ggg ctg ccg ctg tcc gag aag ctg gcg gcc atc aac ttc tcg gtg ctg 8678 Gly Leu Pro Leu Ser Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu 255 260 265 agc ctg ggc aag tac tac gct agg aag atc tac aag acc ccg tac gtg 8726 Ser Leu Gly Lys Tyr Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val 270 275 280 ccc ata gac aag gag gtg aag atc gat ggg ttt tac atg cgc atg acc 8774 Pro Ile Asp Lys Glu Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr 285 290 295 300 ctg aaa gtg ctg acc ctg agc gac gat ctg ggg gtg tac cgc aac gac 8822 Leu Lys Val Leu Thr Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp 305 310 315 agg atg cac cgc gcg gtg agc gcc agc cgc cgg cgc gag ctg agc gac 8870 Arg Met His Arg Ala Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp 320 325 330 cag gag ctg atg cac agc ctg cag cgg gcc ctg acc ggg gcc ggg acc 8918 Gln Glu Leu Met His Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr 335 340 345 gag ggg gag agc tac ttt gac atg ggc gcg gac ctg cgc tgg cag ccc 8966 Glu Gly Glu Ser Tyr Phe Asp Met Gly Ala Asp Leu Arg Trp Gln Pro 350 355 360 agc cgc cgg gcc ttg gaa gct gcc ggc ggc gtg ccc tac gtg gag gag 9014 Ser Arg Arg Ala Leu Glu Ala Ala Gly Gly Val Pro Tyr Val Glu Glu 365 370 375 380 gtg gac gat gag gag gag gag ggc gag tac ctg gaa gac tgatggcgcg 9063 Val Asp Asp Glu Glu Glu Glu Gly Glu Tyr Leu Glu Asp 385 390 accgtatttt tgctag atg cag caa cag cca ccg cct cct gat ccc gcg atg 9115 Met Gln Gln Gln Pro Pro Pro Pro Asp Pro Ala Met 395 400 405 cgg gcg gcg ctg cag agc cag ccg tcc ggc att aac tcc tcg gac gat 9163 Arg Ala Ala Leu Gln Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp 410 415 420 tgg acc cag gcc atg caa cgc atc atg gcg ctg acg acc cgc aat ccc 9211 Trp Thr Gln Ala Met Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro 425 430 435 gaa gcc ttt aga cag cag cct cag gcc aac cgg ctc tcg gcc atc ctg 9259 Glu Ala Phe Arg Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu 440 445 450 gag gcc gtg gtg ccc tcg cgc tcg aac ccc acg cac gag aag gtg ctg 9307 Glu Ala Val Val Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu 455 460 465 gcc atc gtg aac gcg ctg gtg gag aac aag gcc atc cgc ggc gac gag 9355 Ala Ile Val Asn Ala Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu 470 475 480 485 gcc ggg ctg gtg tac aac gcg ctg ctg gag cgc gtg gcc cgc tac aac 9403 Ala Gly Leu Val Tyr Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn 490 495 500 agc acc aac gtg cag acg aac ctg gac cgc atg gtg acc gac gtg cgc 9451 Ser Thr Asn Val Gln Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg 505 510 515 gag gcg gtg tcg cag cgc gag cgg ttc cac cgc gag tcg aac ctg ggc 9499 Glu Ala Val Ser Gln Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly 520 525 530 tcc atg gtg gcg ctg aac gcc ttc ctg agc acg cag ccc gcc aac gtg 9547 Ser Met Val Ala Leu Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val 535 540 545 ccc cgg ggc cag gag gac tac acc aac ttc atc agc gcg ctg cgg ctg 9595 Pro Arg Gly Gln Glu Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu 550 555 560 565 atg gtg gcc gag gtg ccc cag agc gag gtg tac cag tcg ggg ccg gac 9643 Met Val Ala Glu Val Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp 570 575 580 tac ttc ttc cag acc agt cgc cag ggc ttg cag acc gtg aac ctg agc 9691 Tyr Phe Phe Gln Thr Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser 585 590 595 cag gct ttc aag aac ttg cag gga ctg tgg ggc gtg cag gcc ccg gtc 9739 Gln Ala Phe Lys Asn Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val 600 605 610 ggg gac cgc gcg acg gtg tcg agc ctg ctg acg ccg aac tcg cgc ctg 9787 Gly Asp Arg Ala Thr Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu 615 620 625 ctg ctg ctg ctg gtg gcg ccc ttc acg gac agc ggc agc gtg agc cgc 9835 Leu Leu Leu Leu Val Ala Pro Phe Thr Asp Ser Gly Ser Val Ser Arg 630 635 640 645 gac tcg tac ctg ggc tac ctg ctt aac ctg tac cgc gag gcc atc ggg 9883 Asp Ser Tyr Leu Gly Tyr Leu Leu Asn Leu Tyr Arg Glu Ala Ile Gly 650 655 660 cag gcg cac gtg gac gag cag acc tac cag gag atc acc cac gtg agc 9931 Gln Ala His Val Asp Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser 665 670 675 cgc gcg ctg ggg cag gag gac ccg ggc aac ctg gag gcc acc ctg aac 9979 Arg Ala Leu Gly Gln Glu Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn 680 685 690 ttc ctg ctg acc aac cgg tcg cag aag atc ccg ccc cag tac gcg ctg 10027 Phe Leu Leu Thr Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu 695 700 705 agc acc gag gag gag cgc atc ctg cgc tac gtg cag cag agc gtg ggg 10075 Ser Thr Glu Glu Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly 710 715 720 725 ctg ttc ctg atg cag gag ggg gcc acg ccc agc gcc gcg ctc gac atg 10123 Leu Phe Leu Met Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met 730 735 740 acc gcg cgc aac atg gag ccc agc atg tac gcc cgc aac cgc ccg ttc 10171 Thr Ala Arg Asn Met Glu Pro Ser Met Tyr Ala Arg Asn Arg Pro Phe 745 750 755 atc aat aag ctg atg gac tac ttg cat cgg gcg gcc gcc atg aac tcg 10219 Ile Asn Lys Leu Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser 760 765 770 gac tac ttt acc aac gcc atc ttg aac ccg cac tgg ctc ccg ccg ccc 10267 Asp Tyr Phe Thr Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro 775 780 785 ggg ttc tac acg ggc gag tac gac atg ccc gac ccc aac gac ggg ttc 10315 Gly Phe Tyr Thr Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe 790 795 800 805 ctg tgg gac gac gtg gac agc agc gtg ttc tcg ccg cgc ccc acc acc 10363 Leu Trp Asp Asp Val Asp Ser Ser Val Phe Ser Pro Arg Pro Thr Thr 810 815 820 acc gtg tgg aag aaa gag ggc ggg gac cgg cgg ccg tcc tcg gcg ctg 10411 Thr Val Trp Lys Lys Glu Gly Gly Asp Arg Arg Pro Ser Ser Ala Leu 825 830 835 tcc ggt cgc gcg ggt gct gcc gcg gcg gtg ccc gag gcc gcc agc ccc 10459 Ser Gly Arg Ala Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro 840 845 850 ttc ccg agc ctg ccc ttt tcg ctg aac agc gtg cgc agc agc gag ctg 10507 Phe Pro Ser Leu Pro Phe Ser Leu Asn Ser Val Arg Ser Ser Glu Leu 855 860 865 ggt cgg ctg acg cgg ccg cgc ctg ctg ggc gag gag gag tac ctg aac 10555 Gly Arg Leu Thr Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn 870 875 880 885 gac tcc ttg ttg agg ccc gag cgc gag aaa aac ttc ccc aat aac ggg 10603 Asp Ser Leu Leu Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly 890 895 900 ata gag agc ctg gtg gac aag atg agc cgc tgg aag acg tac gcg cac 10651 Ile Glu Ser Leu Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala His 905 910 915 gag cac agg gac gag ccc cga gct agc agc agc acc ggc gcc cgt aga 10699 Glu His Arg Asp Glu Pro Arg Ala Ser Ser Ser Thr Gly Ala Arg Arg 920 925 930 cgc cag cgg cac gac agg cag cgg gga ctg gtg tgg gac gat gag gat 10747 Arg Gln Arg His Asp Arg Gln Arg Gly Leu Val Trp Asp Asp Glu Asp 935 940 945 tcc gcc gac gac agc agc gtg ttg gac ttg ggt ggg agt ggt ggt ggt 10795 Ser Ala Asp Asp Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Gly Gly 950 955 960 965 aac ccg ttc gct cac ctg cgc ccc cgt atc ggg cgc ctg atg 10837 Asn Pro Phe Ala His Leu Arg Pro Arg Ile Gly Arg Leu Met 970 975 taagaatctg aaaaaataaa aaaacggtac tcaccaaggc catggcgacc agcgtgcgtt 10897 cttctctgtt gtttgtagta gt atg atg agg cgc gtg tac ccg gag ggt cct 10949 Met Met Arg Arg Val Tyr Pro Glu Gly Pro 980 985 cct ccc tcg tac gag agc gtg atg cag cag gcg gtg gcg gcg gcg atg 10997 Pro Pro Ser Tyr Glu Ser Val Met Gln Gln Ala Val Ala Ala Ala Met 990 995 1000 1005 cag ccc ccg ctg gag gcg cct tac gtg ccc ccg cgg tac ctg gcg 11042 Gln Pro Pro Leu Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala 1010 1015 1020 cct acg gag ggg cgg aac agc att cgt tac tcg gag ctg gca ccc 11087 Pro Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro 1025 1030 1035 ttg tac gat acc acc cgg ttg tac ctg gtg gac aac aag tcg gcg 11132 Leu Tyr Asp Thr Thr Arg Leu Tyr Leu Val Asp Asn Lys Ser Ala 1040 1045 1050 gac atc gcc tcg ctg aac tac cag aac gac cac agc aac ttc ctg 11177 Asp Ile Ala Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu 1055 1060 1065 acc acc gtg gtg cag aac aac gat ttc acc ccc acg gag gcc agc 11222 Thr Thr Val Val Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser 1070 1075 1080 acc cag acc atc aac ttt gac gag cgc tcg cgg tgg ggc ggc cag 11267 Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln 1085 1090 1095 ctg aaa acc atc atg cac acc aac atg ccc aac gtg aac gag ttc 11312 Leu Lys Thr Ile Met His Thr Asn Met Pro Asn Val Asn Glu Phe 1100 1105 1110 atg tac agc aac aag ttc aag gcg cgg gtg atg gtc tcg cgc aag 11357 Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser Arg Lys 1115 1120 1125 acc ccc aac ggg gtc aca gta aca gat ggt agt cag gac gag ctg 11402 Thr Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln Asp Glu Leu 1130 1135 1140 acc tac gag tgg gtg gag ttt gag ctg ccc gag ggc aac ttc tcg 11447 Thr Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn Phe Ser 1145 1150 1155 gtg acc atg acc atc gat ctg atg aac aac gcc atc atc gac aac 11492 Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn 1160 1165 1170 tac ttg gcg gtg gga cgg cag aac ggg gtg ctg gag agc gac atc 11537 Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile 1175 1180 1185 ggc gtg aag ttc gac acg cgc aac ttc cgg ctg ggc tgg gac ccc 11582 Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro 1190 1195 1200 gtg acc gag ctg gtg atg ccg ggc gtg tac acc aac gag gcc ttc 11627 Val Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe 1205 1210 1215 cac ccc gac att gtc ctg ctg ccc ggc tgc ggc gtg gac ttc acc 11672 His Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr 1220 1225 1230 gag agc cgc ctc agc aac ctg ctg ggc atc cgc aag cgg cag ccc 11717 Glu Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro 1235 1240 1245 ttc cag gag ggc ttc cag atc ctg tac gag gac ctg gag ggg ggc 11762 Phe Gln Glu Gly Phe Gln Ile Leu Tyr Glu Asp Leu Glu Gly Gly 1250 1255 1260 aac atc ccc gcg ctg ctg gac gtg gac gcc tac gag aaa agc aag 11807 Asn Ile Pro Ala Leu Leu Asp Val Asp Ala Tyr Glu Lys Ser Lys 1265 1270 1275 gag gag agc gcc gcc gcg gcg acc gca gcc gtg gcc acc gcc tct 11852 Glu Glu Ser Ala Ala Ala Ala Thr Ala Ala Val Ala Thr Ala Ser 1280 1285 1290 acc gag gtg cgg ggc gat aat ttt gct agc gcc gcg gca gtg gcc 11897 Thr Glu Val Arg Gly Asp Asn Phe Ala Ser Ala Ala Ala Val Ala 1295 1300 1305 gag gcg gct gaa acc gaa agt aag ata gtg atc cag ccg gtg gag 11942 Glu Ala Ala Glu Thr Glu Ser Lys Ile Val Ile Gln Pro Val Glu 1310 1315 1320 aag gac agc aag gac agg agc tac aac gtg ctc gcg gac aag aaa 11987 Lys Asp Ser Lys Asp Arg Ser Tyr Asn Val Leu Ala Asp Lys Lys 1325 1330 1335 aac acc gcc tac cgc agc tgg tac ctg gcc tac aac tac ggc gac 12032 Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly Asp 1340 1345 1350 ccc gag aag ggc gtg cgc tcc tgg acg ctg ctc acc acc tcg gac 12077 Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp 1355 1360 1365 gtc acc tgc ggc gtg gag caa gtc tac tgg tcg ctg ccc gac atg 12122 Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser Leu Pro Asp Met 1370 1375 1380 atg caa gac ccg gtc acc ttc cgc tcc acg cga caa gtt agc aac 12167 Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn 1385 1390 1395 tac ccg gtg gtg ggc gcc gag ctc ctg ccc gtc tac tcc aag agc 12212 Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser 1400 1405 1410 ttc ttc aac gag cag gcc gtc tac tcg cag cag ctg cgc gcc ttc 12257 Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Ala Phe 1415 1420 1425 acc tcg ctc acg cac gtc ttc aac cgc ttc ccc gag aac cag atc 12302 Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile 1430 1435 1440 ctc gtc cgc ccg ccc gcg ccc acc att acc acc gtc agt gaa aac 12347 Leu Val Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn 1445 1450 1455 gtt cct gct ctc aca gat cac ggg acc ctg ccg ctg cgc agc agt 12392 Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser 1460 1465 1470 atc cgg gga gtc cag cgc gtg acc gtc act gac gcc aga cgc cgc 12437 Ile Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg Arg 1475 1480 1485 acc tgc ccc tac gtc tac aag gcc ctg ggc gta gtc gcg ccg cgc 12482 Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Val Val Ala Pro Arg 1490 1495 1500 gtc ctc tcg agc cgc acc ttc taaaaa atg tcc att ctc atc tcg ccc 12530 Val Leu Ser Ser Arg Thr Phe Met Ser Ile Leu Ile Ser Pro 1505 1510 agt aat aac acc ggt tgg ggc ctg cgc gcg ccc agc aag atg tac 12575 Ser Asn Asn Thr Gly Trp Gly Leu Arg Ala Pro Ser Lys Met Tyr 1515 1520 1525 gga ggc gct cgc caa cgc tcc acg caa cac ccc gtg cgc gtg cgc 12620 Gly Gly Ala Arg Gln Arg Ser Thr Gln His Pro Val Arg Val Arg 1530 1535 1540 ggg cac ttc cgc gct ccc tgg ggc gcc ctc aag ggt cgc gtg cgc 12665 Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys Gly Arg Val Arg 1545 1550 1555 tcg cgc acc acc gtc gac gac gtg atc gac cag gtg gtg gcc gac 12710 Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val Val Ala Asp 1560 1565 1570 gcg cgc aac tac acg ccc gcc gcc gcg ccc gcc tcc acc gtg gac 12755 Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Ala Ser Thr Val Asp 1575 1580 1585 gcc gtc atc gac agc gtg gtg gcc gac gcg cgc cgg tac gcc cgc 12800 Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala Arg 1590 1595 1600 gcc aag agc cgg cgg cgg cgc atc gcc cgg cgg cac cgg agc acc 12845 Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 1605 1610 1615 ccc gcc atg cgc gcg gcg cga gcc ttg ctg cgc agg gcc agg cgc 12890 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg 1620 1625 1630 acg gga cgc agg gcc atg ctc agg gcg gcc aga cgc gcg gcc tcc 12935 Thr Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser 1635 1640 1645 ggc agc agc agc gcc ggc agg acc cgc aga cgc gcg gcc acg gcg 12980 Gly Ser Ser Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala 1650 1655 1660 gcg gcg gcg gcc atc gcc agc atg tcc cgc ccg cgg cgc ggc aac 13025 Ala Ala Ala Ala Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn 1665 1670 1675 gtg tac tgg gtg cgc gac gcc gcc acc ggt gtg cgc gtg ccc gtg 13070 Val Tyr Trp Val Arg Asp Ala Ala Thr Gly Val Arg Val Pro Val 1680 1685 1690 cgc acc cgc ccc cct cgc act tgaagatgct gacttcgcga tgttgatgtg 13121 Arg Thr Arg Pro Pro Arg Thr 1695 1700 tcccagcggc gaggagg atg tcc aag cgc aaa ttc aag gaa gag atg ctc 13171 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu 1705 1710 cag gtc atc gcg cct gag atc tac ggc ccc gcg gcg gcg gtg aag 13216 Gln Val Ile Ala Pro Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys 1715 1720 1725 gag gaa aga aag ccc cgc aaa ctg aag cgg gtc aaa aag gac aaa 13261 Glu Glu Arg Lys Pro Arg Lys Leu Lys Arg Val Lys Lys Asp Lys 1730 1735 1740 aag gaa gaa gat gtg gac gat atg gtg gag ttt gtg cgc gag ttc 13306 Lys Glu Glu Asp Val Asp Asp Met Val Glu Phe Val Arg Glu Phe 1745 1750 1755 gcc ccc cgg cgg cgc gtg cag tgg cgc ggg cgg aag gtg cgc ccg 13351 Ala Pro Arg Arg Arg Val Gln Trp Arg Gly Arg Lys Val Arg Pro 1760 1765 1770 gtg ctg aga ccc ggc acc acg gtg gtc ttc acg ccc gga gag cgc 13396 Val Leu Arg Pro Gly Thr Thr Val Val Phe Thr Pro Gly Glu Arg 1775 1780 1785 tct ggc acc gcc tcc aag cgc tcc tac gac gag gtg tac ggg gat 13441 Ser Gly Thr Ala Ser Lys Arg Ser Tyr Asp Glu Val Tyr Gly Asp 1790 1795 1800 gat gat att ctg gag cag gcg gcc gag cgc ctg ggc gag ttt gct 13486 Asp Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu Gly Glu Phe Ala 1805 1810 1815 tac ggc aag cgc agc cgc ccc gcg ccc ttg aaa gag gag gcg gtg 13531 Tyr Gly Lys Arg Ser Arg Pro Ala Pro Leu Lys Glu Glu Ala Val 1820 1825 1830 tcc atc ccg ctg gac cac ggc aac ccc acg ccg agc ctg aag ccg 13576 Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu Lys Pro 1835 1840 1845 gtg acc ctg cag cag gtg ctg cca gcc gcg gcg ccg cgc cgg ggg 13621 Val Thr Leu Gln Gln Val Leu Pro Ala Ala Ala Pro Arg Arg Gly 1850 1855 1860 ttc aag cgc gag ggc gag gat ctg tac ccc acc atg cag ctg atg 13666 Phe Lys Arg Glu Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met 1865 1870 1875 gtg ccc aag cgc cag aag ctg gag gac gtg ctg gag cac atg aag 13711 Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu His Met Lys 1880 1885 1890 gtg gac ccg gac gtg cag ccc gag gtc aag gtg cgg ccc atc aag 13756 Val Asp Pro Asp Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys 1895 1900 1905 cag gtg gcc ccg ggc ctg ggc gtg cag acc gtg gac atc aag atc 13801 Gln Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile 1910 1915 1920 ccc acg gag ccc atg gaa acg cag act gag ccc gtg aag ccc agc 13846 Pro Thr Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser 1925 1930 1935 acc agc acc atg gag gtg cag acg gat ccc tgg atg cca gcg gct 13891 Thr Ser Thr Met Glu Val Gln Thr Asp Pro Trp Met Pro Ala Ala 1940 1945 1950 tcc acc acc act cgc cga aga cgc aag tac ggc gcg gcc agc ctg 13936 Ser Thr Thr Thr Arg Arg Arg Arg Lys Tyr Gly Ala Ala Ser Leu 1955 1960 1965 ctg atg ccc aac tac gcg ctg cat cct tcc atc atc ccc acg ccg 13981 Leu Met Pro Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr Pro 1970 1975 1980 ggc tac cgc ggc acg cgc ttc tac cgc ggc tac acc agc agc cgc 14026 Gly Tyr Arg Gly Thr Arg Phe Tyr Arg Gly Tyr Thr Ser Ser Arg 1985 1990 1995 cgc cgc aag acc acc acc cgc cgc cgc cgt cgt cgc agc cgc cgc 14071 Arg Arg Lys Thr Thr Thr Arg Arg Arg Arg Arg Arg Ser Arg Arg 2000 2005 2010 agc agc acc gcg act tcc gcc ttg gtg cgg aga gtg tac cgc agc 14116 Ser Ser Thr Ala Thr Ser Ala Leu Val Arg Arg Val Tyr Arg Ser 2015 2020 2025 ggg cgc gag cct ctg acc ctg ccg cgc gcg cgc tac cac ccg agc 14161 Gly Arg Glu Pro Leu Thr Leu Pro Arg Ala Arg Tyr His Pro Ser 2030 2035 2040 atc gcc att taactaccgc ctcctacttg cagat atg gcc ctc aca tgc cgc 14213 Ile Ala Ile Met Ala Leu Thr Cys Arg 2045 2050 ctc cgc gtc ccc att acg ggc tac cga gga aga aag ccg cgc cgt 14258 Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly Arg Lys Pro Arg Arg 2055 2060 2065 aga agg ctg acg ggg aac ggg ctg cgt cgc cat cac cac cgg cgg 14303 Arg Arg Leu Thr Gly Asn Gly Leu Arg Arg His His His Arg Arg 2070 2075 2080 cgg cgc gcc atc agc aag cgg ttg ggg gga ggc ttc ctg ccc gcg 14348 Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe Leu Pro Ala 2085 2090 2095 ctg atc ccc atc atc gcc gcg gcg atc ggg gcg atc ccc ggc ata 14393 Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro Gly Ile 2100 2105 2110 gct tcc gtg gcg gtg cag gcc tct cag cgc cac tgagacacag 14436 Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 2115 2120 cttggaaaat ttgtaataaa aaatggactg acgctcctgg tcctgtgatg tgtgttttta 14496 g atg gaa gac atc aat ttt tcg tcc ctg gca ccg cga cac ggc acg 14542 Met Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr 2125 2130 2135 cgg ccg ttt atg ggc acc tgg agc gac atc ggc aac agc caa ctg 14587 Arg Pro Phe Met Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu 2140 2145 2150 aac ggg ggc gcc ttc aat tgg agc agt ctc tgg agc ggg ctt aag 14632 Asn Gly Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys 2155 2160 2165 aat ttc ggg tcc acg ctc aaa acc tat ggc aac aag gcg tgg aac 14677 Asn Phe Gly Ser Thr Leu Lys Thr Tyr Gly Asn Lys Ala Trp Asn 2170 2175 2180 agc agc aca ggg cag gcg ctg agg gaa aag ctg aaa gag cag aac 14722 Ser Ser Thr Gly Gln Ala Leu Arg Glu Lys Leu Lys Glu Gln Asn 2185 2190 2195 ttc cag cag aag gtg gtc gat ggc ctg gcc tcg ggc atc aac ggg 14767 Phe Gln Gln Lys Val Val Asp Gly Leu Ala Ser Gly Ile Asn Gly 2200 2205 2210 gtg gtg gac ctg gcc aac cag gcc gtg cag aaa cag atc aac agc 14812 Val Val Asp Leu Ala Asn Gln Ala Val Gln Lys Gln Ile Asn Ser 2215 2220 2225 cgc ctg gac gcg gtc ccg ccc gcg ggg tcc gtg gac atg ccc cag 14857 Arg Leu Asp Ala Val Pro Pro Ala Gly Ser Val Asp Met Pro Gln 2230 2235 2240 gtg gag gag gag ctg cct ccc ctg gac aag cgc ggc gac aag cga 14902 Val Glu Glu Glu Leu Pro Pro Leu Asp Lys Arg Gly Asp Lys Arg 2245 2250 2255 ccg cgt ccc gac gct gag gag acg ctg ctg acg cac acg gac gag 14947 Pro Arg Pro Asp Ala Glu Glu Thr Leu Leu Thr His Thr Asp Glu 2260 2265 2270 ccg ccc ccg tac gag gag gcg gtg aaa ctg ggt ctg ccc acc acg 14992 Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu Gly Leu Pro Thr Thr 2275 2280 2285 cgg ccc gtg gcg cct ctg gcc acc ggg gtg ctg aaa ccc agc agc 15037 Arg Pro Val Ala Pro Leu Ala Thr Gly Val Leu Lys Pro Ser Ser 2290 2295 2300 agc agc agc cag ccc gcg acc ctg gac ttg cct cca cct cgc ccc 15082 Ser Ser Ser Gln Pro Ala Thr Leu Asp Leu Pro Pro Pro Arg Pro 2305 2310 2315 tcc aca gtg gct aag ccc ctg ccg ccg gtg gcc gtc gcg tcg cgc 15127 Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val Ala Ser Arg 2320 2325 2330 gcc ccc cga ggc cgc ccc cag gcg aac tgg cag agc act ctg aac 15172 Ala Pro Arg Gly Arg Pro Gln Ala Asn Trp Gln Ser Thr Leu Asn 2335 2340 2345 agc atc gtg ggt ctg gga gtg cag agt gtg aag cgc cgc cgc tgc 15217 Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg Arg Arg Cys 2350 2355 2360 tat taaaagacac tgtagcgctt aacttgcttg tctgtgtgtg tat atg tat gtc 15272 Tyr Met Tyr Val 2365 cgc cga cca gaa gga gga aga ggc gcg tcg ccg agt tgc aag atg 15317 Arg Arg Pro Glu Gly Gly Arg Gly Ala Ser Pro Ser Cys Lys Met 2370 2375 2380 gcc acc cca tcg atg ctg ccc cag tgg gcg tac atg cac atc gcc 15362 Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 2385 2390 2395 gga cag gac gct tcg gag tac ctg agt ccg ggt ctg gtg cag ttc 15407 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe 2400 2405 2410 gcc cgc gcc aca gac acc tac ttc agt ctg ggg aac aag ttt agg 15452 Ala Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg 2415 2420 2425 aac ccc acg gtg gcg ccc acg cac gat gtg acc acc gac cgc agc 15497 Asn Pro Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser 2430 2435 2440 cag cgg ctg acg ctg cgc ttc gtg ccc gtg gac cgc gag gac aac 15542 Gln Arg Leu Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn 2445 2450 2455 acc tac tcg tac aaa gtg cgc tac acg ctg gcc gtg ggc gac aac 15587 Thr Tyr Ser Tyr Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn 2460 2465 2470 cgc gtg ctg gac atg gcc agc acc tac ttt gac atc cgc ggc gtg 15632 Arg Val Leu Asp Met Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val 2475 2480 2485 ctg gat cgg ggc ccc agc ttc aaa ccc tac tcc ggc acc gcc tac 15677 Leu Asp Arg Gly Pro Ser Phe Lys Pro Tyr Ser Gly Thr Ala Tyr 2490 2495 2500 aac agc ctg gct ccc aag gga gcg ccc aac acc tca caa tgg ata 15722 Asn Ser Leu Ala Pro Lys Gly Ala Pro Asn Thr Ser Gln Trp Ile 2505 2510 2515 acc aaa gac aag aca tac agt ttt gga aat gct cca gtc aga gga 15767 Thr Lys Asp Lys Thr Tyr Ser Phe Gly Asn Ala Pro Val Arg Gly 2520 2525 2530 ttg gac att aca gaa gag ggt ctc caa ata gta acc gat gag tca 15812 Leu Asp Ile Thr Glu Glu Gly Leu Gln Ile Val Thr Asp Glu Ser 2535 2540 2545 ggg ggt gaa agc aag aaa att ttt gca gac aaa acc tat cag cct 15857 Gly Gly Glu Ser Lys Lys Ile Phe Ala Asp Lys Thr Tyr Gln Pro 2550 2555 2560 gaa cct cag ctt gga gat gag gaa tgg cat gat act att gga gct 15902 Glu Pro Gln Leu Gly Asp Glu Glu Trp His Asp Thr Ile Gly Ala 2565 2570 2575 gaa gac aag tat gga ggc aga gcg ctt aaa cct gcc acc aac atg 15947 Glu Asp Lys Tyr Gly Gly Arg Ala Leu Lys Pro Ala Thr Asn Met 2580 2585 2590 aaa ccc tgc tat ggg tct ttc gcc aag cca act aat gct aag gga 15992 Lys Pro Cys Tyr Gly Ser Phe Ala Lys Pro Thr Asn Ala Lys Gly 2595 2600 2605 ggt cag gct aaa agc aga acc aag gac gat ggc act act gag cct 16037 Gly Gln Ala Lys Ser Arg Thr Lys Asp Asp Gly Thr Thr Glu Pro 2610 2615 2620 gat att gac atg gcc ttt ttt gac gat cgc agt cag caa gct agt 16082 Asp Ile Asp Met Ala Phe Phe Asp Asp Arg Ser Gln Gln Ala Ser 2625 2630 2635 ttc agt cca gaa ctt gtt ttg tat act gag aat gtc gat ctg gac 16127 Phe Ser Pro Glu Leu Val Leu Tyr Thr Glu Asn Val Asp Leu Asp 2640 2645 2650 acc ccg gat acc cac att att tac aaa cct ggc act gat gaa aca 16172 Thr Pro Asp Thr His Ile Ile Tyr Lys Pro Gly Thr Asp Glu Thr 2655 2660 2665 agt tct tct ttc aac ttg ggt cag cag tcc atg ccc aac aga ccc 16217 Ser Ser Ser Phe Asn Leu Gly Gln Gln Ser Met Pro Asn Arg Pro 2670 2675 2680 aat tac att ggc ttc aga gac aac ttt atc gga ctc atg tac tac 16262 Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr 2685 2690 2695 aac agc act ggc aat atg ggt gta ctg gct gga cag gcc tcc cag 16307 Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln 2700 2705 2710 ctg aat gct gtg gtg gac ttg cag gac aga aac acc gaa ctg tcc 16352 Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser 2715 2720 2725 tac cag ctc ttg ctt gac tct ctg ggc gac aga acc agg tat ttc 16397 Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp Arg Thr Arg Tyr Phe 2730 2735 2740 agt atg tgg aat cag gcg gtg gac agc tat gac ccc gat gtg cgc 16442 Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg 2745 2750 2755 att att gaa aat cac ggt gtg gag gat gaa ctt ccc aac tat tgc 16487 Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys 2760 2765 2770 ttc cct ttg aat ggt gtg ggc ttt aca gat tca ttc cag gga att 16532 Phe Pro Leu Asn Gly Val Gly Phe Thr Asp Ser Phe Gln Gly Ile 2775 2780 2785 aag gtt aaa act acc aat aac gga aca gca aac gct aca gag tgg 16577 Lys Val Lys Thr Thr Asn Asn Gly Thr Ala Asn Ala Thr Glu Trp 2790 2795 2800 gaa tct gat acc tct gtc aat aat gct aat gag att gcc aag ggc 16622 Glu Ser Asp Thr Ser Val Asn Asn Ala Asn Glu Ile Ala Lys Gly 2805 2810 2815 aat cct ttc gcc atg gag atc aac atc cag gcc aac ctg tgg cgg 16667 Asn Pro Phe Ala Met Glu Ile Asn Ile Gln Ala Asn Leu Trp Arg 2820 2825 2830 aac ttc ctc tac gcg aac gtg gcg ctg tac ctg ccc gac tcc tac 16712 Asn Phe Leu Tyr Ala Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr 2835 2840 2845 aag tac acg ccg gcc aac atc acg ctg ccc acc aac acc aac acc 16757 Lys Tyr Thr Pro Ala Asn Ile Thr Leu Pro Thr Asn Thr Asn Thr 2850 2855 2860 tac gat tac atg aac ggc cgc gtg gtg gcg ccc tcg ctg gtg gac 16802 Tyr Asp Tyr Met Asn Gly Arg Val Val Ala Pro Ser Leu Val Asp 2865 2870 2875 gcc tac atc aac atc ggg gcg cgc tgg tcg ctg gac ccc atg gac 16847 Ala Tyr Ile Asn Ile Gly Ala Arg Trp Ser Leu Asp Pro Met Asp 2880 2885 2890 aac gtc aac ccc ttc aac cac cac cgc aac gcg ggc ctg cga tac 16892 Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr 2895 2900 2905 cgc tcc atg ctc ctg ggc aac ggg cgc tac gtg ccc ttc cac atc 16937 Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile 2910 2915 2920 cag gtg ccc caa aag ttt ttc gcc atc aag agc ctc ctg ctc ctg 16982 Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu Leu Leu Leu 2925 2930 2935 ccc ggg tcc tac acc tac gag tgg aac ttc cgc aag gac gtc aac 17027 Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn 2940 2945 2950 atg atc ctg cag agc tcc ctc ggc aac gac ctg cgc acg gac ggg 17072 Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Thr Asp Gly 2955 2960 2965 gcc tcc atc tcc ttc acc agc atc aac ctc tac gcc acc ttc ttc 17117 Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala Thr Phe Phe 2970 2975 2980 ccc atg gcg cac aac acg gcc tcc acg ctc gag gcc atg ctg cgc 17162 Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg 2985 2990 2995 aac gac acc aac gac cag tcc ttc aac gac tac ctc tcg gcg gcc 17207 Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala Ala 3000 3005 3010 aac atg ctc tac ccc atc ccg gcc aac gcc acc aac gtg ccc atc 17252 Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Val Pro Ile 3015 3020 3025 tcc atc ccc tcg cgc aac tgg gcc gcc ttc cgc ggc tgg tcc ttc 17297 Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe 3030 3035 3040 acg cgt ctc aag acc aag gag acg ccc tcg ctg ggc tcc ggg ttc 17342 Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe 3045 3050 3055 gac ccc tac ttc gtc tac tcg ggc tcc atc ccc tac ctc gac ggc 17387 Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly 3060 3065 3070 acc ttc tac ctc aac cac acc ttc aag aag gtc tcc atc acc ttc 17432 Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe 3075 3080 3085 gac tcc tcc gtc agc tgg ccc ggc aac gac cgc ctc ctg acg ccc 17477 Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro 3090 3095 3100 aac gag ttc gaa atc aag cgc acc gtc gac gga gag ggg tac aac 17522 Asn Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn 3105 3110 3115 gtg gcc cag tgc aac atg acc aag gac tgg ttc ctg gtc cag atg 17567 Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met 3120 3125 3130 ctg gcc cac tac aac atc ggc tac cag ggc ttc tac gtg ccc gag 17612 Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu 3135 3140 3145 ggc tac aag gac cgc atg tac tcc ttc ttc cgc aac ttc cag ccc 17657 Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro 3150 3155 3160 atg agc cgc cag gtc gtg gac gag gtc aac tac aag gac tac cag 17702 Met Ser Arg Gln Val Val Asp Glu Val Asn Tyr Lys Asp Tyr Gln 3165 3170 3175 gcc gtc acc ctg gcc tac cag cac aac aac tcg ggc ttc gtc ggc 17747 Ala Val Thr Leu Ala Tyr Gln His Asn Asn Ser Gly Phe Val Gly 3180 3185 3190 tac ctc gcg ccc acc atg cgc cag ggg cag ccc tac ccc gcc aac 17792 Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln Pro Tyr Pro Ala Asn 3195 3200 3205 tac ccg tac ccg ctc atc ggc aag agc gcc gtc acc agc gtc acc 17837 Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val Thr Ser Val Thr 3210 3215 3220 cag aaa aag ttc ctc tgc gac cgg gtc atg tgg cgc atc ccc ttc 17882 Gln Lys Lys Phe Leu Cys Asp Arg Val Met Trp Arg Ile Pro Phe 3225 3230 3235 tcc agc aac ttc atg tcc atg ggc gcg ctc acc gac ctc ggc cag 17927 Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln 3240 3245 3250 aac atg ctc tat gcc aac tcc gcc cac gcg cta gac atg aat ttc 17972 Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Asn Phe 3255 3260 3265 gaa gtc gac ccc atg gat gag tcc acc ctt ctc tat gtt gtc ttc 18017 Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr Val Val Phe 3270 3275 3280 gaa gtc ttc gac gtc gtc cga gtg cac cag ccc cac cgc ggc gtc 18062 Glu Val Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val 3285 3290 3295 atc gag gcc gtc tac ctg cgc acc ccc ttc tcg gcc ggt aac gcc 18107 Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala 3300 3305 3310 acc acc taagctcttg cttcttgc atg atg gct gag ccc acg ggc tcc ggc 18158 Thr Thr Met Met Ala Glu Pro Thr Gly Ser Gly 3315 3320 gag cag gag ctc agg gcc atc atc cgc gac ctg ggc tgc ggg ccc 18203 Glu Gln Glu Leu Arg Ala Ile Ile Arg Asp Leu Gly Cys Gly Pro 3325 3330 3335 tac ttc ctg ggc acc ttc gat aag cgc ttc ccg gga ttc atg gcc 18248 Tyr Phe Leu Gly Thr Phe Asp Lys Arg Phe Pro Gly Phe Met Ala 3340 3345 3350 ccg cac aag ctg gcc tgc gcc atc gtc aac acg gcc ggt cgc gag 18293 Pro His Lys Leu Ala Cys Ala Ile Val Asn Thr Ala Gly Arg Glu 3355 3360 3365 acc ggg ggc gag cac tgg ctg gcc ttc gcc tgg aac ccg cgc tcg 18338 Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp Asn Pro Arg Ser 3370 3375 3380 aac acc tgc tac ctc ttc gac ccc ttc ggg ttc tcg gac gag cgc 18383 Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser Asp Glu Arg 3385 3390 3395 ctc aag cag atc tac cag ttc gag tac gag ggc ctg ctg cgc cgc 18428 Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu Leu Arg Arg 3400 3405 3410 agc gcc ctg gcc acc gag gac cgc tgc gtc acc ctg gaa aag tcc 18473 Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu Lys Ser 3415 3420 3425 acc cag acc gtg cag ggt ccg cgc tcg gcc gcc tgc ggg ctc ttc 18518 Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu Phe 3430 3435 3440 tgc tgc atg ttc ctg cac gcc ttc gtg cac tgg ccc gac cgc ccc 18563 Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro 3445 3450 3455 atg gac aag aac ccc acc atg aac ttg ctg acg ggg gtg ccc aac 18608 Met Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn 3460 3465 3470 ggc atg ctc cag tcg ccc cag gtg gaa ccc acc ctg cgc cgc aac 18653 Gly Met Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn 3475 3480 3485 cag gag gcg ctc tac cgc ttc ctc aac gcc cac tcc gcc tac ttt 18698 Gln Glu Ala Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe 3490 3495 3500 cgc tcc cac cgc gcg cgc atc gag aag gcc acc gcc ttc gac cgc 18743 Arg Ser His Arg Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg 3505 3510 3515 atg aat caa gac atg taaaccgtgt gtgtatgtga atgctttatt cataataaac 18798 Met Asn Gln Asp Met 3520 agcacatgtt tatgccacct tctctgaggc tctgacttta tttagaaatc gaaggggttc 18858 tgccggctct cggcgtgccc cgcgggcagg gatacgttgc ggaactggta cttgggcagc 18918 cacttgaact cggggatcag cagcttcggc acggggaggt cggggaacga gtcgctccac 18978 agcttgcgcg tgagttgcag ggcgcccagc aggtcgggcg cggagatctt gaaatcgcag 19038 ttgggacccg cgttctgcgc gcgagagttg cggtacacgg ggttgcagca ctggaacacc 19098 atcagggccg ggtgcttcac gctcgccagc accgtcgcgt cggtgatgcc ctccacgtcc 19158 agatcctcgg cgttggccat cccgaagggg gtcatcttgc aggtctgccg ccccatgctg 19218 ggcacgcagc cgggcttgtg gttgcaatcg cagtgcaggg ggatcagcat catctgggcc 19278 tgctcggagc tcatgcccgg gtacatggcc ttcatgaaag cctccagctg gcggaaggcc 19338 tgctgcgcct tgccgccctc ggtgaagaag accccgcagg acttgctaga gaactggttg 19398 gtagcgcagc ccgcgtcgtg cacgcagcag cgcgcgtcgt tgttggccag ctgcaccacg 19458 ctgcgccccc agcggttctg ggtgatcttg gcccggtcgg ggttctcctt cagcgcgcgc 19518 tgcccgttct cgctcgccac atccatctcg atcgtgtgct ccttctggat catcacggtc 19578 ccgtgcaggc accgcagctt gccctcggcc tcggtgcagc cgtgcagcca cagcgcgcag 19638 ccggtgctct cccagttctt gtgggcgatc tgggagtgcg agtgcacgaa gccctgcagg 19698 aagcggccca tcatcgcggt cagggtcttg ttgctggtga aggtcagcgg gatgccgcgg 19758 tgctcctcgt tcacatacag gtggcagatg cggcggtaca cctcgccctg ctcgggcatc 19818 agctggaagg cggacttcag gtcgctctcc acgcggtacc gctccatcag cagcgtcatc 19878 acttccatgc ccttctccca ggccgaaacg atcggcaggc tcagggggtt cttcaccgtc 19938 atcttagtcg ccgccgccga ggtcaggggg tcgttctcgt ccagggtctc aaacactcgc 19998 ttgccgtcct tctcggtgat gcgcacgggg gggaaggcga agcccacggc cgccagctcc 20058 tcctcggcct gcctttcgtc ctcgctgtcc tggctgatgt cttgcaaagg cacatgcttg 20118 gtcttgcggg gtttcttttt gggcggcaga ggcggcggcg gagacgtgct gggcgagcgc 20178 gagttctcgc tcaccacgac tatttcttct tcttggccgt cgtccgagac cacgcggcgg 20238 taggcatgcc tcttctgggg cagaggcgga ggcgacgggc tctcgcggtt cgacgggcgg 20298 ctggcagagc cccttccgcg ttcgggggtg cgctcctggc ggcgctgctc tgactgactt 20358 cctccgcggc cggccattgt gttctcctag ggagcaacaa gc atg gag act cag 20412 Met Glu Thr Gln 3525 cca tcg tcg cca aca tcg cca tct gcc ccc gcc gcc gcc gac gag 20457 Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ala Ala Asp Glu 3530 3535 3540 aac cag cag cag cag aat gaa agc tta acc gcc ccg ccg ccc agc 20502 Asn Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro Pro Ser 3545 3550 3555 ccc acc tcc gac gcc gcc gca gcc cca gac atg caa gag atg gag 20547 Pro Thr Ser Asp Ala Ala Ala Ala Pro Asp Met Gln Glu Met Glu 3560 3565 3570 gaa tcc atc gag att gac ctg ggc tac gtg acg ccc gcg gag cac 20592 Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His 3575 3580 3585 gag gag gag ctg gca gcg cgc ttt tca gcc ccg gaa gag aac cac 20637 Glu Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His 3590 3595 3600 caa gag cag cca gag cag gaa gca gag agc gag cag cag cag gct 20682 Gln Glu Gln Pro Glu Gln Glu Ala Glu Ser Glu Gln Gln Gln Ala 3605 3610 3615 ggg ctc gag cat ggc gac tac ctg agc ggg gca gag gac gtg ctc 20727 Gly Leu Glu His Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu 3620 3625 3630 atc aag cat ctg gcc cgc caa tgc atc atc gtc aag gac gcg ctg 20772 Ile Lys His Leu Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu 3635 3640 3645 ctc gac cgc gcc gag gtg ccc ctc agc gtg gcg gag ctc agc cgc 20817 Leu Asp Arg Ala Glu Val Pro Leu Ser Val Ala Glu Leu Ser Arg 3650 3655 3660 gcc tac gag cgc aac ctc ttc tcg ccg cgc gtg ccc ccc aag cgc 20862 Ala Tyr Glu Arg Asn Leu Phe Ser Pro Arg Val Pro Pro Lys Arg 3665 3670 3675 cag ccc aac ggc acc tgc gag ccc aac ccg cgc ctc aac ttc tac 20907 Gln Pro Asn Gly Thr Cys Glu Pro Asn Pro Arg Leu Asn Phe Tyr 3680 3685 3690 ccg gtc ttc gcg gtg ccc gag gcc ctg gcc acc tac cac ctc ttt 20952 Pro Val Phe Ala Val Pro Glu Ala Leu Ala Thr Tyr His Leu Phe 3695 3700 3705 ttc aag aac caa agg atc ccc gtc tcc tgc cgc gcc aac cgc acc 20997 Phe Lys Asn Gln Arg Ile Pro Val Ser Cys Arg Ala Asn Arg Thr 3710 3715 3720 cgc gcc gac gcc ctg ctc aac ctg ggc ccc ggc gcc cgc cta cct 21042 Arg Ala Asp Ala Leu Leu Asn Leu Gly Pro Gly Ala Arg Leu Pro 3725 3730 3735 gat atc gcc tcc ttg gaa gag gtt ccc aag atc ttc gag ggt ctg 21087 Asp Ile Ala Ser Leu Glu Glu Val Pro Lys Ile Phe Glu Gly Leu 3740 3745 3750 ggc agc gac gag act cgg gcc gcg aac gct ctg caa gga agc gga 21132 Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu Gln Gly Ser Gly 3755 3760 3765 gag gag cat gag cac cac agc gcc ctg gtg gag ttg gaa ggc gac 21177 Glu Glu His Glu His His Ser Ala Leu Val Glu Leu Glu Gly Asp 3770 3775 3780 aac gcg cgc ctg gcg gtc ctc aag cgc acg gtc gag ctg acc cac 21222 Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu Thr His 3785 3790 3795 ttc gcc tac cca gcg ctc aac ctg ccc ccc aag gtc atg agc gcc 21267 Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser Ala 3800 3805 3810 gtc atg gac cag gtg ctc atc aag cgc gcc tcg ccc ctc tcg gag 21312 Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu 3815 3820 3825 gag gag atg cag gac ccc gag agc tcg gac gag ggc aag ccc gtg 21357 Glu Glu Met Gln Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val 3830 3835 3840 gtc agc gac gag cag ctg gcg cgc tgg ctg gga gcg agt agc acc 21402 Val Ser Asp Glu Gln Leu Ala Arg Trp Leu Gly Ala Ser Ser Thr 3845 3850 3855 ccc cag agc ctg gaa gag cgg cgc aag ctc atg atg gcc gtg gtc 21447 Pro Gln Ser Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val 3860 3865 3870 ctg gtg acc gtg gag ctg gag tgt ctg cgc cgc ttc ttt gcc gac 21492 Leu Val Thr Val Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp 3875 3880 3885 gcg gag acc ctg cgc aag gtc gag gag aac ctg cac tac ctc ttc 21537 Ala Glu Thr Leu Arg Lys Val Glu Glu Asn Leu His Tyr Leu Phe 3890 3895 3900 agg cac ggg ttc gtg cgc cag gcc tgc aag atc tcc aac gtg gag 21582 Arg His Gly Phe Val Arg Gln Ala Cys Lys Ile Ser Asn Val Glu 3905 3910 3915 ctg acc aac ctg gtc tcc tac atg ggc atc ctg cac gag aac cgc 21627 Leu Thr Asn Leu Val Ser Tyr Met Gly Ile Leu His Glu Asn Arg 3920 3925 3930 ctg ggg cag aac gtg ctg cac acc acc ctg cgc ggg gag gcc cgc 21672 Leu Gly Gln Asn Val Leu His Thr Thr Leu Arg Gly Glu Ala Arg 3935 3940 3945 cgc gac tac atc cgc gac tgc gtc tac ctg tac ctc tgc cac acc 21717 Arg Asp Tyr Ile Arg Asp Cys Val Tyr Leu Tyr Leu Cys His Thr 3950 3955 3960 tgg cag acg ggc atg ggc gtg tgg cag cag tgc ctg gag gag cag 21762 Trp Gln Thr Gly Met Gly Val Trp Gln Gln Cys Leu Glu Glu Gln 3965 3970 3975 aac ctg aaa gag ctc tgc aag ctc ctg cag aag aac ctc aag gcc 21807 Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys Asn Leu Lys Ala 3980 3985 3990 ctg tgg acc ggg ttc gac gag cgc acc acc gcc tcg gac ctg gcc 21852 Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser Asp Leu Ala 3995 4000 4005 gac ctc atc ttc ccc gag cgc ctg cgg ctg acg ctg cgc aac ggg 21897 Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg Asn Gly 4010 4015 4020 ctg ccc gac ttt atg agc caa agc atg ttg caa aac ttt cgc tct 21942 Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg Ser 4025 4030 4035 ttc atc ctc gaa cgc tcc ggg atc ctg ccc gcc acc tgc tcc gca 21987 Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala 4040 4045 4050 ctg ccc tcg gac ttc gtg ccg ctg acc ttc cgc gag tgc ccc ccg 22032 Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro 4055 4060 4065 ccg ctc tgg agc cac tgc tac ctg ctg cgc ctg gcc aac tac ctg 22077 Pro Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu 4070 4075 4080 gcc tac cac tcg gac gtg atc gag gac gtc agc ggc gag ggt ctg 22122 Ala Tyr His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu 4085 4090 4095 ctc gag tgc cac tgc cgc tgc aac ctc tgc acg ccg cac cgc tcc 22167 Leu Glu Cys His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser 4100 4105 4110 ctg gcc tgc aac ccc cag ctg ctg agc gag acc cag atc atc ggc 22212 Leu Ala Cys Asn Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly 4115 4120 4125 acc ttc gag ttg caa ggg ccc ggt gac ggc aag ggg ggt ctg aaa 22257 Thr Phe Glu Leu Gln Gly Pro Gly Asp Gly Lys Gly Gly Leu Lys 4130 4135 4140 ctc acc ccg ggg ctg tgg acc tcg gcc tac ttg cgc aag ttc gtg 22302 Leu Thr Pro Gly Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val 4145 4150 4155 ccc gag gac tac cat ccc ttc gag atc agg ttc tac gag gac caa 22347 Pro Glu Asp Tyr His Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln 4160 4165 4170 tcc cag ccg ccc aag gcc gag ctg tcg gcc tgc gtc atc acc cag 22392 Ser Gln Pro Pro Lys Ala Glu Leu Ser Ala Cys Val Ile Thr Gln 4175 4180 4185 ggg gcc atc ctg gcc caa ttg caa gcc atc cag aaa tcc cgc caa 22437 Gly Ala Ile Leu Ala Gln Leu Gln Ala Ile Gln Lys Ser Arg Gln 4190 4195 4200 gaa ttt ctg ctg aaa aag ggc cac ggg gtc tac ctg gac ccc cag 22482 Glu Phe Leu Leu Lys Lys Gly His Gly Val Tyr Leu Asp Pro Gln 4205 4210 4215 acc gga gag gag ctc aac ccc agc ttc ccc cag gat gcc ccg agg 22527 Thr Gly Glu Glu Leu Asn Pro Ser Phe Pro Gln Asp Ala Pro Arg 4220 4225 4230 aag cag caa gaa gct gaa agt gga gct gcc gcc gga gga ttt gga 22572 Lys Gln Gln Glu Ala Glu Ser Gly Ala Ala Ala Gly Gly Phe Gly 4235 4240 4245 gga aga ctg gga gag cag tca ggc aga gga gat gga aga ctg gga 22617 Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly Asp Gly Arg Leu Gly 4250 4255 4260 cag cac tca ggc aga gga gga cag cct gca aga cag tct gga aga 22662 Gln His Ser Gly Arg Gly Gly Gln Pro Ala Arg Gln Ser Gly Arg 4265 4270 4275 cga ggt gga gga gga ggc aga gga aga agc agc cgc cgc cag acc 22707 Arg Gly Gly Gly Gly Gly Arg Gly Arg Ser Ser Arg Arg Gln Thr 4280 4285 4290 gtc gtc ctc ggc gga gga gga gaa agc aag cag cac gga tac cat 22752 Val Val Leu Gly Gly Gly Gly Glu Ser Lys Gln His Gly Tyr His 4295 4300 4305 ctc cgc tcc ggg tcr ggg tcg cgg cgg ccg ggc cca cag taggtgggac 22801 Leu Arg Ser Gly Xaa Gly Ser Arg Arg Pro Gly Pro Gln 4310 4315 gagaccgggc gcttcccgaa ccccaccacc cagaccggta agaaggagcg gcagggatac 22861 aagtcctggc gggggcacaa aaacgccatc gtctcctgct tgcaagcctg cgggggcaac 22921 atctccttca cccggcgcta cctgctcttc caccgcgggg tgaacttccc ccgcaacatc 22981 ttgcattact accgtcacct ccacagcccc tactactgtt tccaagaaga ggcagaaacc 23041 cagcagcagc agaaaaccag cggcagctag aaaatccaca gcggcggcgg caggtggact 23101 gaggatcgcg gcgaacgagc cggcgcagac ccgggagctg aggaaccgga tctttcccac 23161 cctctatgcc atcttccagc agagtcgggg gcaggagcag gaactgaaag tcaagaaccg 23221 ttctctgcgc tcgctcaccc gcagttgtct gtatcacaag agcgaagacc aacttcagcg 23281 cactctcgag gacgccgagg ctctcttcaa caagtactgc gcgctcactc ttaaagagta 23341 gcccgcgccc gcccacacac ggaaaaaggc gggaattacg tcaccacctg cgcccttcgc 23401 ccgaccatca tc atg agc aaa gag att ccc acg cct tac atg tgg agc 23449 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser 4320 4325 4330 tac cag ccc cag atg ggc ctg gcc gcc ggc gcc gcc cag gac tac 23494 Tyr Gln Pro Gln Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr 4335 4340 4345 tcc acc cgc atg aac tgg ctc agt gcc ggg ccc gcg atg atc tca 23539 Ser Thr Arg Met Asn Trp Leu Ser Ala Gly Pro Ala Met Ile Ser 4350 4355 4360 cgg gtg aat gac atc cgc gcc cac cga aac cag ata ctc cta gaa 23584 Arg Val Asn Asp Ile Arg Ala His Arg Asn Gln Ile Leu Leu Glu 4365 4370 4375 cag tca gcg atc acc gcc acg ccc cgc cat cac ctt aat ccg cgt 23629 Gln Ser Ala Ile Thr Ala Thr Pro Arg His His Leu Asn Pro Arg 4380 4385 4390 aat tgg ccc gcc gcc ctg gtg tac cag gaa att ccc cag ccc acg 23674 Asn Trp Pro Ala Ala Leu Val Tyr Gln Glu Ile Pro Gln Pro Thr 4395 4400 4405 acc gta cta ctt ccg cga gac gcc cag gcc gaa gtc cag ctg act 23719 Thr Val Leu Leu Pro Arg Asp Ala Gln Ala Glu Val Gln Leu Thr 4410 4415 4420 aac tca ggt gtc cag ctg gcc ggc ggc gcc acc ctg tgt cgt cac 23764 Asn Ser Gly Val Gln Leu Ala Gly Gly Ala Thr Leu Cys Arg His 4425 4430 4435 cgc ccc gct cag ggt ata aag cgg ctg gtg atc cga ggc aga ggc 23809 Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile Arg Gly Arg Gly 4440 4445 4450 aca cag ctc aac gac gag gtg gtg agc tct tcg ctg ggt ctg cga 23854 Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu Gly Leu Arg 4455 4460 4465 cct gac gga gtc ttc caa ctc gcc gga tcg ggg aga tct tcc ttc 23899 Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser Ser Phe 4470 4475 4480 acg cct cgt cag gcc gtc ctg act ttg gag agt tcg tcc tca cag 23944 Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser Gln 4485 4490 4495 ccc cgc tcg ggc ggc atc ggc act ctc cag ttc gtg gag gag ttc 23989 Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 4500 4505 4510 act ccc tcg gtc tac ttc aac ccc ttc tcc ggc tcc ccc ggc cac 24034 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His 4515 4520 4525 tac ccg gac gag ttc atc ccg aac ttc gac gcc atc agc gag tcg 24079 Tyr Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser 4530 4535 4540 gtg gac ggc tac gat tga atg tcc cat ggt ggc gtg gct gac cta 24124 Val Asp Gly Tyr Asp Met Ser His Gly Gly Val Ala Asp Leu 4545 4550 4555 gct cgg ctt cga cac ctg gac cac tgc cgc cgc ttc cgc tgc ttc 24169 Ala Arg Leu Arg His Leu Asp His Cys Arg Arg Phe Arg Cys Phe 4560 4565 4570 gct cgg gat ctc gcc gag ttt gcc tac ttt gag ctg ccc gag gag 24214 Ala Arg Asp Leu Ala Glu Phe Ala Tyr Phe Glu Leu Pro Glu Glu 4575 4580 4585 cac cct cag ggc ccg gcc cac gga gtg cgg atc atc gtc gaa ggg 24259 His Pro Gln Gly Pro Ala His Gly Val Arg Ile Ile Val Glu Gly 4590 4595 4600 ggt ctc gac tcc cac ctg ctt cgg atc ttc agc cag cga ccg atc 24304 Gly Leu Asp Ser His Leu Leu Arg Ile Phe Ser Gln Arg Pro Ile 4605 4610 4615 ctg gtc gag cgc gag caa gga cag acc cgt ctg acc ctg tac tgc 24349 Leu Val Glu Arg Glu Gln Gly Gln Thr Arg Leu Thr Leu Tyr Cys 4620 4625 4630 atc tgc aac cac ccc ggc ctg cat gaa agt ctt tgt tgt ctg ctg 24394 Ile Cys Asn His Pro Gly Leu His Glu Ser Leu Cys Cys Leu Leu 4635 4640 4645 tgt act gag tat aat aaa agc tgagatcagc gactactccg gactcgattg 24445 Cys Thr Glu Tyr Asn Lys Ser 4650 tggtgttcct gctatcaacc agtccctgtt cttcaccggg aacgagaccg agctccagct 24505 ccagtgtaag ccccacaaga agtatctcac ctggctgttc cagggctccc cgatcgccgt 24565 tgtcaaccac tgcgacaacg acggagtcct gctgagcggc cctgccaacc ttactttttc 24625 cacccgcaga agcaagctcc agctcttcca acccttcctc cccgggacct atcagtgcgt 24685 ctcgggaccc tgccatcaca ccttccacct gatcccgaat accacagcgc cgctccccgc 24745 tactaacaac caaactaccc accaacgcca ccgtcgcgac ctttcctctg aatctaatac 24805 cactaccgga ggtgagctcc gaggtcgacc aacctctggg atttactacg gcccctggga 24865 ggtggtgggg ttaatagcgc taggcctagt tgtgggtggg cttttggctc tctgctacct 24925 atacctccct tgctgttcgt acttagtggt gctgtgttgc tggtttaaga a atg ggg 24982 Met Gly cag atc acc cta gtg agc tgc ggt gtg ctg gtg gcg gtg ctt tcg 25027 Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val Leu Ser 4655 4660 4665 att gtg gga ctg ggc ggc gcg gct gta gtg aag gag gag aag gcc 25072 Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu Glu Lys Ala 4670 4675 4680 gat ccc tgc ttg cat ttc aat ccc gac aaa tgc cag ctg agt ttt 25117 Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe 4685 4690 4695 cag ccc gat ggc aat cgg tgc gcg gtg ctg atc aag tgc gga tgg 25162 Gln Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp 4700 4705 4710 gaa tgc gag aac gtg aga atc gag tac aat aac aag act cgg aac 25207 Glu Cys Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn 4715 4720 4725 aat act ctc gcg tcc gtg tgg cag ccc ggg gac ccc gag tgg tac 25252 Asn Thr Leu Ala Ser Val Trp Gln Pro Gly Asp Pro Glu Trp Tyr 4730 4735 4740 acc gtc tct gtc ccc ggt gct gac ggc tcc ccg cgc acc gtg aac 25297 Thr Val Ser Val Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn 4745 4750 4755 aat act ttc att ttt gcg cac atg tgc gac acg gtc atg tgg atg 25342 Asn Thr Phe Ile Phe Ala His Met Cys Asp Thr Val Met Trp Met 4760 4765 4770 agc aag cag tac gat atg tgg ccc ccc acg aag gag aac atc gtg 25387 Ser Lys Gln Tyr Asp Met Trp Pro Pro Thr Lys Glu Asn Ile Val 4775 4780 4785 gtc ttc tcc atc gct tac agc ctg tgc acg gtg cta atc acc gct 25432 Val Phe Ser Ile Ala Tyr Ser Leu Cys Thr Val Leu Ile Thr Ala 4790 4795 4800 atc gtg tgc ctg agc att cac atg ctc atc gct att cgc ccc aga 25477 Ile Val Cys Leu Ser Ile His Met Leu Ile Ala Ile Arg Pro Arg 4805 4810 4815 aat aat gcc gaa aaa gaa aaa cag cca taacacgttt tttcacacac 25524 Asn Asn Ala Glu Lys Glu Lys Gln Pro 4820 4825 ctttttcaga cc atg gcc tct gtt aaa ttt ttg ctt tta ttt gcc agt 25572 Met Ala Ser Val Lys Phe Leu Leu Leu Phe Ala Ser 4830 4835 4840 ctc att act gtt ata agt aat gag aaa ctc act att tac att ggc 25617 Leu Ile Thr Val Ile Ser Asn Glu Lys Leu Thr Ile Tyr Ile Gly 4845 4850 4855 act aac cac act cta gaa gga att cca aaa tcc tca tgg tat tgc 25662 Thr Asn His Thr Leu Glu Gly Ile Pro Lys Ser Ser Trp Tyr Cys 4860 4865 4870 tat ttt gat caa gat cca gac tta act ata gaa ctg tgt ggt aac 25707 Tyr Phe Asp Gln Asp Pro Asp Leu Thr Ile Glu Leu Cys Gly Asn 4875 4880 4885 aat gga caa aat aca agc att cat tta att aac ttt aaa tgc gga 25752 Asn Gly Gln Asn Thr Ser Ile His Leu Ile Asn Phe Lys Cys Gly 4890 4895 4900 gac gat ttg aaa tta att aat atc act aaa gag tat gga ggt atg 25797 Asp Asp Leu Lys Leu Ile Asn Ile Thr Lys Glu Tyr Gly Gly Met 4905 4910 4915 tat tac tat gtt gca gaa aat aac aac atg cag ttt tat gaa gtt 25842 Tyr Tyr Tyr Val Ala Glu Asn Asn Asn Met Gln Phe Tyr Glu Val 4920 4925 4930 act gta act aat ccc acc aca cct aga aca aca aca acc acc aca 25887 Thr Val Thr Asn Pro Thr Thr Pro Arg Thr Thr Thr Thr Thr Thr 4935 4940 4945 aaa act aca cct gtt acc act atg cag ctc gct acc aat aac att 25932 Lys Thr Thr Pro Val Thr Thr Met Gln Leu Ala Thr Asn Asn Ile 4950 4955 4960 ttt gcc atg cgt caa atg gtc aac aat agc act caa ccc acc cca 25977 Phe Ala Met Arg Gln Met Val Asn Asn Ser Thr Gln Pro Thr Pro 4965 4970 4975 ccc agt gag gaa att ccc aaa tcc atg att ggc att att gtt gct 26022 Pro Ser Glu Glu Ile Pro Lys Ser Met Ile Gly Ile Ile Val Ala 4980 4985 4990 gta gtg gtg tgc atg ttg atc atc gcc ttg tgc atg gtg tac tat 26067 Val Val Val Cys Met Leu Ile Ile Ala Leu Cys Met Val Tyr Tyr 4995 5000 5005 gcc ttc tgc tac aga aag cac aga ctg aac gac aag ctg gaa cac 26112 Ala Phe Cys Tyr Arg Lys His Arg Leu Asn Asp Lys Leu Glu His 5010 5015 5020 tta cta agt gtt gaa ttt taatttttta gaaccatgaa gatcctaggc 26160 Leu Leu Ser Val Glu Phe 5025 cttttagttt tttctatcat tacctctgct ctttgtgaat cagtggataa agatgttact 26220 attaccactg gttctaacta tacactgaaa gggccaccct caggtatgct ttcgtggtat 26280 tgctattttg gaaatgacgc agagcaaact gagctttgca atgcaatgaa aggccaaatg 26340 ccaaccacaa aaattaaaca taaatgtgat ggtagtgatc taatactact caatgtcacg 26400 aaagcatatg gtggcagtta ttcatgccct gctgccaaca ctgaggatat gattttttac 26460 aaagtggaag tggttgatcc cactactcca ccacccacca ccacaactac tcacaccaca 26520 cacacagaac aaaccacagc agaggaggca gcaaagttag ccttgcaggt ccaagacagt 26580 tcatttgttg gcattacccc tacacccgat cagcggtgtc cggggctgct cgtcagcggc 26640 attgtcggtg tgctttcggg attagcagtc ataatcatct gcatgttcat ttttgcttgc 26700 tgctatagaa ggctttaccg acaaaaatca gacccactgc tgaacctcta tgtttaattt 26760 tttccagagc c atg aag gca gtt agc act cta att ttt tgt tct ttg 26807 Met Lys Ala Val Ser Thr Leu Ile Phe Cys Ser Leu 5030 5035 att ggc act gtt ttt agt gtt agc ttt ttg aaa caa att aat gtt 26852 Ile Gly Thr Val Phe Ser Val Ser Phe Leu Lys Gln Ile Asn Val 5040 5045 5050 act gag ggg gaa aat gtg aca ctg gta ggc gta gaa ggt gct caa 26897 Thr Glu Gly Glu Asn Val Thr Leu Val Gly Val Glu Gly Ala Gln 5055 5060 5065 aat acc acc tgg aca aaa tac cac ctc gat ggg tgg aaa gat att 26942 Asn Thr Thr Trp Thr Lys Tyr His Leu Asp Gly Trp Lys Asp Ile 5070 5075 5080 tgc aat tgg agt gtc att act tac aca tgt gag gga gtt aat ttg 26987 Cys Asn Trp Ser Val Ile Thr Tyr Thr Cys Glu Gly Val Asn Leu 5085 5090 5095 acc ata gtc aat gcc agc caa aat cag aag ggt tgg att aaa ggg 27032 Thr Ile Val Asn Ala Ser Gln Asn Gln Lys Gly Trp Ile Lys Gly 5100 5105 5110 caa tct gtt agt gtt acc agc cag ggg tac tat acc cag cat act 27077 Gln Ser Val Ser Val Thr Ser Gln Gly Tyr Tyr Thr Gln His Thr 5115 5120 5125 ctt att tat gac att gta gtt ata ccg ctg cca acg cct agc cca 27122 Leu Ile Tyr Asp Ile Val Val Ile Pro Leu Pro Thr Pro Ser Pro 5130 5135 5140 cct agc acc act aca caa aca acc cac act aca cag aca acc aca 27167 Pro Ser Thr Thr Thr Gln Thr Thr His Thr Thr Gln Thr Thr Thr 5145 5150 5155 tac agt aca tca aat caa cct acc acc act aca gca gca gag gtt 27212 Tyr Ser Thr Ser Asn Gln Pro Thr Thr Thr Thr Ala Ala Glu Val 5160 5165 5170 gcc agc tcg tct ggg gtc cga gtg gca ttt ttg tta ttg gcc cca 27257 Ala Ser Ser Ser Gly Val Arg Val Ala Phe Leu Leu Leu Ala Pro 5175 5180 5185 tct agc agt ccc act gct agt acc aat gag cag act act gat ttt 27302 Ser Ser Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Asp Phe 5190 5195 5200 ttg tcc act gtc gag agc cac acc aca gct acc tcg agt gcc ttc 27347 Leu Ser Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe 5205 5210 5215 tct agc acc gcc aat ctc tcc tcg ctt tcc tct aca cca atc agt 27392 Ser Ser Thr Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser 5220 5225 5230 ccc gct act act cct agc ccc gct cct ctt ccc act ccc ctg aag 27437 Pro Ala Thr Thr Pro Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys 5235 5240 5245 caa aca gac ggc ggc atg caa tgg cag atc acc ctg ctc att gtg 27482 Gln Thr Asp Gly Gly Met Gln Trp Gln Ile Thr Leu Leu Ile Val 5250 5255 5260 atc ggg ttg gtc atc ctg gcc gtg ttg ctc tac tac atc ttc tgc 27527 Ile Gly Leu Val Ile Leu Ala Val Leu Leu Tyr Tyr Ile Phe Cys 5265 5270 5275 cgc cgc att ccc aac gcg cac cgc aag ccg gcc tac aag ccc atc 27572 Arg Arg Ile Pro Asn Ala His Arg Lys Pro Ala Tyr Lys Pro Ile 5280 5285 5290 gtt atc ggg cag ccg gag ccg ctt cag gtg gaa ggg ggt cta agg 27617 Val Ile Gly Gln Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg 5295 5300 5305 aat ctt ctc ttc tct ttt aca gta tgg tgattgaact atgattccta 27664 Asn Leu Leu Phe Ser Phe Thr Val Trp 5310 5315 gacaattctt gatcactatt cttatctgcc tcctccaagt ctgtgccacc ctcgctctgg 27724 tggccaacgc cagtccagac tgtattgggc ccttcgcctc ctacgtgctc tttgccttcg 27784 tcacctgcat ctgctgctgt agcatagtct gcctgcttat caccttcttc cagttcattg 27844 actggatctt tgtgcgcatc gcctacctgc gccaccaccc ccagtaccgc gaccagcgag 27904 tggcgcggct gctcaggctc ctctgataag c atg cgg gct ctg cta ctt ctc 27956 Met Arg Ala Leu Leu Leu Leu 5320 gcg ctt ctg ctg tta gtg ctc ccc cgt ccc gtc gac ccc cgg tcc 28001 Ala Leu Leu Leu Leu Val Leu Pro Arg Pro Val Asp Pro Arg Ser 5325 5330 5335 ccc act cag tcc ccc gag gag gtc cgc aaa tgc aaa ttc caa gaa 28046 Pro Thr Gln Ser Pro Glu Glu Val Arg Lys Cys Lys Phe Gln Glu 5340 5345 5350 ccc tgg aaa ttc ctc aaa tgc tac cgc caa aaa tca gac atg cat 28091 Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys Ser Asp Met His 5355 5360 5365 ccc agc tgg atc atg atc att ggg atc gtg aac att ctg gcc tgc 28136 Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile Leu Ala Cys 5370 5375 5380 acc ctc atc tcc ttt gtg att tac ccc tac ttt gac ttt ggt tgg 28181 Thr Leu Ile Ser Phe Val Ile Tyr Pro Tyr Phe Asp Phe Gly Trp 5385 5390 5395 aac tcg cca gag gcg ctc tat ctc ccg cct gaa cct gac aca cca 28226 Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr Pro 5400 5405 5410 cca cag caa cct cag gca cac gca cta cca cca cca cag cct agg 28271 Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Pro Gln Pro Arg 5415 5420 5425 cca caa tac atg ccc ata tta gac tat gag gcc gag cca cag cga 28316 Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg 5430 5435 5440 ccc atg ctc ccc gct att agt tac ttc aat cta acc ggc gga gat 28361 Pro Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp 5445 5450 5455 gac tgacccactg gccaacaaca acgtcaacga ccttctcctg gacatggacg 28414 Asp 5460 gccgcgcctc ggagcagcga ctcgcccaac ttcgcattcg ccagcagcag gagagagccg 28474 tcaaggagct gcaggacggc atagccatcc accagtgcaa gaaaggcatc ttctgcctgg 28534 tgaaacaggc caagatctcc tacgaggtca cccagaccga ccatcgcctc tcctacgagc 28594 tcctgcagca gcgccagaag ttcacctgcc tggtcggagt caaccccatc gtcatcaccc 28654 agcagtcggg agataccaag gggtgcatcc actgctcctg cgactccccc gactgcgtcc 28714 acactctgat caagaccctc tgcggcctcc gcgacctcct ccccatgaac taatcacccc 28774 cttatccagt gaaataaaga tcatattgat gattaaataa aaaaaataat catttgattt 28834 gaaataaaga tacaatcata ttgatgattt gagtttaata aaaataaaga atcacttact 28894 tgaaatctga taccaggtct ctgtccatgt tttctgccaa caccacttca ctcccctctt 28954 cccagctctg gtactgcagg ccccggcggg ctgcaaactt cctccacacc ctgaagggga 29014 tgtcaaattc ctcctgtccc tcaatcttca ttttatcttc tatcag atg tcc aaa 29069 Met Ser Lys aag cgc gtc cgg gtg gat gat gac ttc gac ccc gtc tac ccc tac 29114 Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro Val Tyr Pro Tyr 5465 5470 5475 gat gca gac aac gca ccg acc gtg ccc ttc atc aac ccc ccc ttc 29159 Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro Phe 5480 5485 5490 gtc tct tca gat gga ttc caa gag aag ccc ctg ggg gtg ttg tcc 29204 Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser 5495 5500 5505 ctg cga ctg gcc gac ccc gtc acc acc aag aac ggg gaa atc acc 29249 Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Glu Ile Thr 5510 5515 5520 ctc aag ctg gga gag ggg gtg gac ctc gac gac tcg gga aaa ctc 29294 Leu Lys Leu Gly Glu Gly Val Asp Leu Asp Asp Ser Gly Lys Leu 5525 5530 5535 atc tcc aaa aat gcc acc aag gcc act gcc cct ctc agt att tcc 29339 Ile Ser Lys Asn Ala Thr Lys Ala Thr Ala Pro Leu Ser Ile Ser 5540 5545 5550 aac agc acc att tcc ctt aac atg gat gcc cct ctt tac aac aac 29384 Asn Ser Thr Ile Ser Leu Asn Met Asp Ala Pro Leu Tyr Asn Asn 5555 5560 5565 aat gga aag tta ggc ata aga ata gga gca cct cta aag gta gta 29429 Asn Gly Lys Leu Gly Ile Arg Ile Gly Ala Pro Leu Lys Val Val 5570 5575 5580 gac tta cta aac act tta gct gta gcc tat gga tcg ggt cta ggt 29474 Asp Leu Leu Asn Thr Leu Ala Val Ala Tyr Gly Ser Gly Leu Gly 5585 5590 5595 ctc aag aat aat gcc ctt aca gtt cag tta gtt tct cca ctc act 29519 Leu Lys Asn Asn Ala Leu Thr Val Gln Leu Val Ser Pro Leu Thr 5600 5605 5610 ttt gat aac aaa ggc aat gta aaa att aam tta ggg aaa ggc cca 29564 Phe Asp Asn Lys Gly Asn Val Lys Ile Xaa Leu Gly Lys Gly Pro 5615 5620 5625 tta aca gtt gcg gca aac cga ctg agt gtt acc tgc aaa aga ggt 29609 Leu Thr Val Ala Ala Asn Arg Leu Ser Val Thr Cys Lys Arg Gly 5630 5635 5640 tta tat gtc act act aca gga gat gca ctc gaa agc aac ata agc 29654 Leu Tyr Val Thr Thr Thr Gly Asp Ala Leu Glu Ser Asn Ile Ser 5645 5650 5655 tgg gct aaa ggt ata aga ttt gaa gga aat gca ata gca gca aat 29699 Trp Ala Lys Gly Ile Arg Phe Glu Gly Asn Ala Ile Ala Ala Asn 5660 5665 5670 att ggc aaa ggg ctt gaa ttt ggt act act agt tca gag tca gat 29744 Ile Gly Lys Gly Leu Glu Phe Gly Thr Thr Ser Ser Glu Ser Asp 5675 5680 5685 gtc agc aat gct tat cct atc caa gta aaa cta ggt act ggt ctc 29789 Val Ser Asn Ala Tyr Pro Ile Gln Val Lys Leu Gly Thr Gly Leu 5690 5695 5700 acc ttt gac agc aca ggt gcc att gtt gct tgg aac aaa gag gat 29834 Thr Phe Asp Ser Thr Gly Ala Ile Val Ala Trp Asn Lys Glu Asp 5705 5710 5715 gac aag ctt aca ttg tgg acc aca gcc gac cca tcg cca aat tgc 29879 Asp Lys Leu Thr Leu Trp Thr Thr Ala Asp Pro Ser Pro Asn Cys 5720 5725 5730 aaa ata tac tct gaa aag gat gca aaa ctt aca ctt tgc ttg aca 29924 Lys Ile Tyr Ser Glu Lys Asp Ala Lys Leu Thr Leu Cys Leu Thr 5735 5740 5745 aag tgt ggt agt caa ata ttg ggc act gtg aca gta ttg gct gtt 29969 Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Thr Val Leu Ala Val 5750 5755 5760 aac aat ggg agc tta aac ccc att aca aac aca gtg agc act gca 30014 Asn Asn Gly Ser Leu Asn Pro Ile Thr Asn Thr Val Ser Thr Ala 5765 5770 5775 att gta tat ctc aag ttt gat gct aat gga gtc ttg cta agc aac 30059 Ile Val Tyr Leu Lys Phe Asp Ala Asn Gly Val Leu Leu Ser Asn 5780 5785 5790 tca aca cta aac aaa gaa tat tgg aat ttc aga aag gga gat gtt 30104 Ser Thr Leu Asn Lys Glu Tyr Trp Asn Phe Arg Lys Gly Asp Val 5795 5800 5805 aca cct gcc gaa gca tac act aat gct ata ggt ttt atg cct aac 30149 Thr Pro Ala Glu Ala Tyr Thr Asn Ala Ile Gly Phe Met Pro Asn 5810 5815 5820 ata aag gcc tat cct aaa aac aca tct gca gct tca aaa agt cat 30194 Ile Lys Ala Tyr Pro Lys Asn Thr Ser Ala Ala Ser Lys Ser His 5825 5830 5835 att gtt ggc caa gtt tac cta aat gga gat gaa acc aaa cct ctt 30239 Ile Val Gly Gln Val Tyr Leu Asn Gly Asp Glu Thr Lys Pro Leu 5840 5845 5850 atg cta att atc aca ttt aat gaa act gat gat gca acc tgc acc 30284 Met Leu Ile Ile Thr Phe Asn Glu Thr Asp Asp Ala Thr Cys Thr 5855 5860 5865 tac tgc att act ttt caa tgg aaa tgg gat aat agt aag tac aca 30329 Tyr Cys Ile Thr Phe Gln Trp Lys Trp Asp Asn Ser Lys Tyr Thr 5870 5875 5880 ggt gaa aca ctt gca acc agc tcc ttt ccc ttc tcc tac att gcc 30374 Gly Glu Thr Leu Ala Thr Ser Ser Phe Pro Phe Ser Tyr Ile Ala 5885 5890 5895 caa gaa taaaccaccc tgcatgacac cccttgtccc actgctctac aatggaaaac 30430 Gln Glu 5900 tctgaagcag aaaaataaag ttcaagtgtt ttattgattc aacagtttta caggactcga 30490 gcagttattt ttcctccacc ctcccaggac atggaataca ccaccctctc cccccgcaca 30550 gccttgaaca tctgaatgtc attggtgatg gacatgcttt tggtctccac gttccacaca 30610 gtttcagagc gagccagtct cgggtcggtc agggagatga aaccctccgg gcactcccgc 30670 atctgcacct cacagctcaa cagctgagga ttgtcctcgg tggtcgggat cacggttatc 30730 tggaagaagc agaagagcgg cggtgggaat catagtccgc gaacgggatc ggccggtggt 30790 gtcgcatcag gccccgcagc agtcgctgtc gccgccgctc cgtcaaactg ctgctcaggg 30850 ggtccgggtc cagggactcc ctcagcatga tgcccacggc cctcagcatc agtcgcctgg 30910 tgcggcgggc gcagcagcgc atgcggatct cgctcaggtc gctgcagtac gtgcaacaca 30970 ggaccaccag gttgttcaac agtccatagt tcaacacgct ccagccgaaa ctcatcgcgg 31030 gaaggatgct acccacgtgg ccgtcgtacc agatcctcag gtaaatcaag tggcgctccc 31090 tccagaacac gctgcccaca tacatgatct ccttgggcat gtggcggttc accacctccc 31150 ggtaccacat caccctctgg ttgaacatgc agccccggat gatcctgcgg aaccacaggg 31210 ccagcaccgc cccgcccgcc atgcagcgaa gagaccccgg gtcccggcaa tggcaatgga 31270 ggacccaccg ctcgtacccg tggatcatct gggagctgaa caagtctatg ttggcacagc 31330 acaggcacac gctcatgcat ctcttcagca ctctcagctc ctcgggggtc aaaaccatat 31390 cccagggcac ggggaactct tgcaggacag cgaaccccgc agaacagggc aatcctcgca 31450 cataacttac attgtgcatg gacagggtat cgcaatcagg cagcaccggg tgatcctcca 31510 ccagagaagc gcgggtctcg gtttcctcac agcgtggtaa gggggccggc cgatacgggt 31570 gatggcggga cgcggctgat cgtgttctcg accgtgtcat gatgcagttg ctttcggaca 31630 ttttcgtact tgctgtagca gaacctggtc cgggcgctgc acaccgatcg ccggcggcgg 31690 tctcggcgct tggaacgctc ggtgttgaaa ttgtaaaaca gccactctct cagaccgtgc 31750 agcagatcta gggcctcagg agtgatgaag atcccatcat gcctgatggc tctgatcaca 31810 tcgaccaccg tggaatgggc cagacccagc cagatgatgc aattttgttg ggtttcggtg 31870 acggcggggg agggaagaac aggaagaacc atgattaact tttaatccaa acggtctcgg 31930 agcacttcaa aatgaaggtc gcggagatgg cacctctcgc ccccgctgtg ttggtggaaa 31990 ataacagcca ggtcaaaggt gatacggttc tcgagatgtt ccacggtggc ttccagcaaa 32050 gcctccacgc gcacatccag aaacaagaca atagcgaaag cgggagggtt ctctaattcc 32110 tcaatcatca tgttacactc ctgcaccatc cccagataat tttcattttt ccagccttga 32170 atgattcgaa ctagttcctg aggtaaatcc aagccagcca tgataaagag ctcgcgcaga 32230 gcgccctcca ccggcattct taagcacacc ctcataattc caagatattc tgctcctggt 32290 tcacctgcag cagattgaca agcggaatat caaaatctct gccgcgatcc ctgagctcct 32350 ccctcagcaa taactgtaag tactctttca tatcctctcc aaaattttta gccataggac 32410 caccaggaat aagattagga caagccacag tacagataaa ccgaagtcct ccccagtgag 32470 cattgccaaa tgcaagactg ctataagcat gctggctaga cccggtgata tcttccagat 32530 aactggacag aaaatcgccc aggcaatttt taagaaaatc aacaaaagaa aaatcctcca 32590 ggtgcacgtt tagagcctcg ggaacaacga tggagtaaat gcaagcggtg cgttccagca 32650 tggttagtta gctgatctgt agaaaaaaca aaaatgaaca ttaaaccatg ctagcctggc 32710 gaacaggtgg gtaaatcgtt ctctccagca ccaggcaggc cacggggtct ccggcgcgac 32770 cctcgtaaaa attgtcgcta tgattgaaaa ccatcacaga gagacgttcc cggtggccgg 32830 cgtggatgat tcgacaagat gaatacaccc ccggaacatt ggcgtccgcg agtgaaaaaa 32890 agcgcccaag gaagcaataa ggcactacaa tgctcagtct caagtccagc aaagcgatgc 32950 catgcggatg aagcacaaaa ttctcaggtg cgtacaaaat gtaattactc ccctcctgca 33010 caggcagcaa agcccccgat ccctccagat acacatacaa agcctcagcg tccatagctt 33070 accgagcagc agcacacaac aggcgcaaga gtcagagaaa ggctgagctc taacctgtcc 33130 acccgctctc tgctcaatat atagcccaga tctacactga cgtaaaggcc aaagtctaaa 33190 aatacccgcc aaataatcac acacgcccaa cacacgccca gaaaccggtg acacactcag 33250 aaaaatacgc gcacttcctc aaacgcccaa actgccgtca tttccgggtt cccacgctac 33310 gtcatcagaa ttcgactttc aaattccgtc gaccgttaaa aacgtcaccc gccccgcccc 33370 taacggtcgc cgctcccgca gccaatcaca gccccgcagc cccaaattca aacgcctcat 33430 ttgcatatta acacgcacaa aaagtttgag gtatattatt gatgatgtaa gctagatatc 33490 gtttaaacta tgcggtgtga aataccgcac agatgcgtaa ggagaaaata ccgcatcagg 33550 cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg 33610 gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga 33670 aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg 33730 gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag 33790 aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc 33850 gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg 33910 ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt 33970 cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc 34030 ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc 34090 actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg 34150 tggcctaact acggctacac tagaaggaca gtatttggta tctgcgctct gctgaagcca 34210 gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc 34270 ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat 34330 cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt 34390 ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt 34450 tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc 34510 agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcccc 34570 gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc tgcaatgata 34630 ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc agccggaagg 34690 gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat taattgttgc 34750 cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt tgccattgct 34810 gcaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc cggttcccaa 34870 cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag ctccttcggt 34930 cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt tatggcagca 34990 ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac tggtgagtac 35050 tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg cccggcgtca 35110 acacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat tggaaaacgt 35170 tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc gatgtaaccc 35230 actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc tgggtgagca 35290 aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa atgttgaata 35350 ctcatactct tcctttttca atattattga agcatttatc agggttattg tctcatgagc 35410 ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc 35470 cgaaaagtgc cacctgacgt ctaagaaacc attattatca tgacattaac ctataaaaat 35530 aggcgtatca cgaggccctt tcgtcttcaa gaattgttta aactaccatc atcaataata 35590 tacctcaaac tttttgtgcg tgttaatatg caaatgaggc gtttgaattt ggggctgcgg 35650 ggctgtgatt ggctgcggga gcggcgaccg ttaggggcgg ggcgggtgac gtttcgatga 35710 cgtgacgtga ggcggagccg gtttgcaagt tctcgtggga aaagtgacgt caaacgaggt 35770 gtggtttgaa cacggaaata ctcaattttc ccgcgctctc tgacaggaaa tgaggtgttt 35830 ctgggcggat gcaagtgaaa acgggccatt ttcgcgcgaa aactaaatga ggaagtgaaa 35890 atctgagtaa ttccgcgttt atggcaggga ggagtatttg ccgagggccg agtagacttt 35950 gaccgattac gtgggggttt cgattaccgt atttttcacc taaatttccg cgtacggtgt 36010 caaagtccgg tgtttttacg ggctgcagga attcgatatc atttccccga aaagtgccac 36070 ctgacgtaac tataacggtc ctaaggtagc gaaagctcag atctggatct cccgatcccc 36130 tatggcgact ctcagtacaa tctgctctga tgccgcatag ttaagccagt atctgctccc 36190 tgcttgtgtg ttggaggtcg ctgagtagtg cgcgagcaaa atttaagcta caacaaggca 36250 aggcttgacc gacaattgca tgaagaatct gcttagggtt aggcgttttg cgctgcttcg 36310 cgatgtacgg gccagatata cgcgttgaca ttgattattg actagttatt aatagtaatc 36370 aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt 36430 aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta 36490 tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg actatttacg 36550 gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga 36610 cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt 36670 tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg 36730 gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc 36790 cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg 36850 taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat 36910 aagcagagct cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga 36970 cctccataga agacaccggg accgatccag cctccgcggg cgcgcgtcga cagagag 37027 atg ggt gcg aga gcg tca gta tta agc ggg gga gaa tta gat cga 37072 Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg 5905 5910 5915 tgg gaa aaa att cgg tta agg cca ggg gga aag aag aag tac aag 37117 Trp Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys 5920 5925 5930 cta aag cac atc gta tgg gca agc agg gag cta gaa cga ttc gca 37162 Leu Lys His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala 5935 5940 5945 gtt aat cct ggc ctg tta gaa aca tca gaa ggc tgt aga caa ata 37207 Val Asn Pro Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile 5950 5955 5960 ctg gga cag cta caa cca tcc ctt cag aca gga tca gag gag ctt 37252 Leu Gly Gln Leu Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu 5965 5970 5975 cga tca cta tac aac aca gta gca acc ctc tat tgt gtg cac cag 37297 Arg Ser Leu Tyr Asn Thr Val Ala Thr Leu Tyr Cys Val His Gln 5980 5985 5990 cgg atc gag atc aag gac acc aag gaa gct tta gac aag ata gag 37342 Arg Ile Glu Ile Lys Asp Thr Lys Glu Ala Leu Asp Lys Ile Glu 5995 6000 6005 gaa gag caa aac aag tcc aag aag aag gcc cag cag gca gca gct 37387 Glu Glu Gln Asn Lys Ser Lys Lys Lys Ala Gln Gln Ala Ala Ala 6010 6015 6020 gac aca gga cac agc aat cag gtc agc caa aat tac cct ata gtg 37432 Asp Thr Gly His Ser Asn Gln Val Ser Gln Asn Tyr Pro Ile Val 6025 6030 6035 cag aac atc cag ggg caa atg gta cat cag gcc ata tca cct aga 37477 Gln Asn Ile Gln Gly Gln Met Val His Gln Ala Ile Ser Pro Arg 6040 6045 6050 act tta aat gca tgg gta aaa gta gta gaa gag aag gct ttc agc 37522 Thr Leu Asn Ala Trp Val Lys Val Val Glu Glu Lys Ala Phe Ser 6055 6060 6065 cca gaa gtg ata ccc atg ttt tca gca tta tca gaa gga gcc acc 37567 Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser Glu Gly Ala Thr 6070 6075 6080 cca cag gac ctg aac acg atg ttg aac acc gtg ggg gga cat caa 37612 Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln 6085 6090 6095 gca gcc atg caa atg tta aaa gag acc atc aat gag gaa gct gca 37657 Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu Ala Ala 6100 6105 6110 gat tgg gat aga gtg cat cca gtg cat gca ggg cct att gca cca 37702 Asp Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala Pro 6115 6120 6125 ggc cag atg aga gaa cca agg gga agt gac ata gca gga act act 37747 Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 6130 6135 6140 agt acc ctt cag gaa caa ata gga tgg atg aca aat aat cca cct 37792 Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro 6145 6150 6155 atc cca gta gga gag atc tac aag agg tgg ata atc ctg gga ttg 37837 Ile Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu 6160 6165 6170 aac aag atc gtg agg atg tat agc cct acc agc att ctg gac ata 37882 Asn Lys Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile 6175 6180 6185 aga caa gga cca aag gaa ccc ttt aga gac tat gta gac cgg ttc 37927 Arg Gln Gly Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe 6190 6195 6200 tat aaa act cta aga gct gag caa gct tca cag gag gta aaa aat 37972 Tyr Lys Thr Leu Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn 6205 6210 6215 tgg atg aca gaa acc ttg ttg gtc caa aat gcg aac cca gat tgt 38017 Trp Met Thr Glu Thr Leu Leu Val Gln Asn Ala Asn Pro Asp Cys 6220 6225 6230 aag acc atc ctg aag gct ctc ggc cca gcg gct aca cta gaa gaa 38062 Lys Thr Ile Leu Lys Ala Leu Gly Pro Ala Ala Thr Leu Glu Glu 6235 6240 6245 atg atg aca gca tgt cag gga gta gga gga ccc ggc cat aag gca 38107 Met Met Thr Ala Cys Gln Gly Val Gly Gly Pro Gly His Lys Ala 6250 6255 6260 aga gtt ttg tag ggatccacta gttctagact cgaggggggg cccggtacct 38159 Arg Val Leu ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg 38219 ggactggaag ggctaattca ctcccaaaga agacaagata aaccgctgat cagcctcgac 38279 tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct 38339 ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct 38399 gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg 38459 ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag 38519 aaccagcaga tctgcagatc tgaattcatc tatgtcgggt gc 38561 <210> 105 <211> 393 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 105 Met His Pro Val Leu Arg Gln Met Arg Pro His His Pro Pro Pro Gln 1 5 10 15 Gln Gln Pro Pro Pro Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln 20 25 30 Gln Gln Leu Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala Gly 35 40 45 Gln Ser Tyr Asp His Gln Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala 50 55 60 Arg Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys 65 70 75 80 Arg Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp 85 90 95 Arg Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ser Arg Phe His Ala 100 105 110 Gly Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp 115 120 125 Glu Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala 130 135 140 His Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys 145 150 155 160 Glu Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu 165 170 175 Ile Ala Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu 180 185 190 Leu Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln 195 200 205 Leu Phe Leu Val Val Gln His Ser Arg Asp Asn Glu Thr Phe Arg Glu 210 215 220 Ala Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu 225 230 235 240 Val Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu 245 250 255 Ser Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys 260 265 270 Tyr Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys 275 280 285 Glu Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu 290 295 300 Thr Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg 305 310 315 320 Ala Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met 325 330 335 His Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser 340 345 350 Tyr Phe Asp Met Gly Ala Asp Leu Arg Trp Gln Pro Ser Arg Arg Ala 355 360 365 Leu Glu Ala Ala Gly Gly Val Pro Tyr Val Glu Glu Val Asp Asp Glu 370 375 380 Glu Glu Glu Gly Glu Tyr Leu Glu Asp 385 390 <210> 106 <211> 586 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 106 Met Gln Gln Gln Pro Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu 1 5 10 15 Gln Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala 20 25 30 Met Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg 35 40 45 Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val 50 55 60 Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn 65 70 75 80 Ala Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val 85 90 95 Tyr Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val 100 105 110 Gln Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ser 115 120 125 Gln Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala 130 135 140 Leu Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln 145 150 155 160 Glu Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Ala Glu 165 170 175 Val Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln 180 185 190 Thr Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys 195 200 205 Asn Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala 210 215 220 Thr Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu 225 230 235 240 Val Ala Pro Phe Thr Asp Ser Gly Ser Val Ser Arg Asp Ser Tyr Leu 245 250 255 Gly Tyr Leu Leu Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val 260 265 270 Asp Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly 275 280 285 Gln Glu Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr 290 295 300 Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu 305 310 315 320 Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met 325 330 335 Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn 340 345 350 Met Glu Pro Ser Met Tyr Ala Arg Asn Arg Pro Phe Ile Asn Lys Leu 355 360 365 Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr 370 375 380 Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr 385 390 395 400 Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp 405 410 415 Val Asp Ser Ser Val Phe Ser Pro Arg Pro Thr Thr Thr Val Trp Lys 420 425 430 Lys Glu Gly Gly Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly Arg Ala 435 440 445 Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu 450 455 460 Pro Phe Ser Leu Asn Ser Val Arg Ser Ser Glu Leu Gly Arg Leu Thr 465 470 475 480 Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu 485 490 495 Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu 500 505 510 Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala His Glu His Arg Asp 515 520 525 Glu Pro Arg Ala Ser Ser Ser Thr Gly Ala Arg Arg Arg Gln Arg His 530 535 540 Asp Arg Gln Arg Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp Asp 545 550 555 560 Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe Ala 565 570 575 His Leu Arg Pro Arg Ile Gly Arg Leu Met 580 585 <210> 107 <211> 528 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 107 Met Met Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Val Ala Ala Ala Met Gln Pro Pro Leu Glu Ala 20 25 30 Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg Asn Ser 35 40 45 Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg Leu Tyr 50 55 60 Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr Gln Asn 65 70 75 80 Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp Phe Thr 85 90 95 Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg 100 105 110 Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro Asn Val 115 120 125 Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser 130 135 140 Arg Lys Thr Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln Asp Glu 145 150 155 160 Leu Thr Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn Phe Ser 165 170 175 Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr 180 185 190 Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val 195 200 205 Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val Thr Glu 210 215 220 Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro Asp Ile 225 230 235 240 Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg Leu Ser 245 250 255 Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly Phe Gln 260 265 270 Ile Leu Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp 275 280 285 Val Asp Ala Tyr Glu Lys Ser Lys Glu Glu Ser Ala Ala Ala Ala Thr 290 295 300 Ala Ala Val Ala Thr Ala Ser Thr Glu Val Arg Gly Asp Asn Phe Ala 305 310 315 320 Ser Ala Ala Ala Val Ala Glu Ala Ala Glu Thr Glu Ser Lys Ile Val 325 330 335 Ile Gln Pro Val Glu Lys Asp Ser Lys Asp Arg Ser Tyr Asn Val Leu 340 345 350 Ala Asp Lys Lys Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn 355 360 365 Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr 370 375 380 Ser Asp Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser Leu Pro Asp 385 390 395 400 Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn 405 410 415 Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser Phe 420 425 430 Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Ala Phe Thr Ser 435 440 445 Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Val Arg 450 455 460 Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu 465 470 475 480 Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln 485 490 495 Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr 500 505 510 Lys Ala Leu Gly Val Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 515 520 525 <210> 108 <211> 194 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 108 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Ala Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ser 130 135 140 Ser Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala 145 150 155 160 Ala Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val 165 170 175 Arg Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro 180 185 190 Arg Thr <210> 109 <211> 344 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 109 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys Glu Glu Arg Lys Pro Arg 20 25 30 Lys Leu Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Asp Val Asp Asp 35 40 45 Met Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp 50 55 60 Arg Gly Arg Lys Val Arg Pro Val Leu Arg Pro Gly Thr Thr Val Val 65 70 75 80 Phe Thr Pro Gly Glu Arg Ser Gly Thr Ala Ser Lys Arg Ser Tyr Asp 85 90 95 Glu Val Tyr Gly Asp Asp Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu 100 105 110 Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Pro Ala Pro Leu Lys Glu 115 120 125 Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu 130 135 140 Lys Pro Val Thr Leu Gln Gln Val Leu Pro Ala Ala Ala Pro Arg Arg 145 150 155 160 Gly Phe Lys Arg Glu Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met 165 170 175 Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu His Met Lys Val 180 185 190 Asp Pro Asp Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln Val 195 200 205 Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr Glu 210 215 220 Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr Met 225 230 235 240 Glu Val Gln Thr Asp Pro Trp Met Pro Ala Ala Ser Thr Thr Thr Arg 245 250 255 Arg Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn Tyr Ala 260 265 270 Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg Phe 275 280 285 Tyr Arg Gly Tyr Thr Ser Ser Arg Arg Arg Lys Thr Thr Thr Arg Arg 290 295 300 Arg Arg Arg Arg Ser Arg Arg Ser Ser Thr Ala Thr Ser Ala Leu Val 305 310 315 320 Arg Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu Thr Leu Pro Arg Ala 325 330 335 Arg Tyr His Pro Ser Ile Ala Ile 340 <210> 110 <211> 77 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 110 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly Asn Gly Leu Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 111 <211> 241 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 111 Met Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg 1 5 10 15 Pro Phe Met Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly 20 25 30 Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly 35 40 45 Ser Thr Leu Lys Thr Tyr Gly Asn Lys Ala Trp Asn Ser Ser Thr Gly 50 55 60 Gln Ala Leu Arg Glu Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val 65 70 75 80 Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn 85 90 95 Gln Ala Val Gln Lys Gln Ile Asn Ser Arg Leu Asp Ala Val Pro Pro 100 105 110 Ala Gly Ser Val Asp Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu 115 120 125 Asp Lys Arg Gly Asp Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu 130 135 140 Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu 145 150 155 160 Gly Leu Pro Thr Thr Arg Pro Val Ala Pro Leu Ala Thr Gly Val Leu 165 170 175 Lys Pro Ser Ser Ser Ser Ser Gln Pro Ala Thr Leu Asp Leu Pro Pro 180 185 190 Pro Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val Ala 195 200 205 Ser Arg Ala Pro Arg Gly Arg Pro Gln Ala Asn Trp Gln Ser Thr Leu 210 215 220 Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg Arg Arg Cys 225 230 235 240 Tyr <210> 112 <211> 950 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 112 Met Tyr Val Arg Arg Pro Glu Gly Gly Arg Gly Ala Ser Pro Ser Cys 1 5 10 15 Lys Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile 20 25 30 Ala Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe 35 40 45 Ala Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn 50 55 60 Pro Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg 65 70 75 80 Leu Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser 85 90 95 Tyr Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp 100 105 110 Met Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro 115 120 125 Ser Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys 130 135 140 Gly Ala Pro Asn Thr Ser Gln Trp Ile Thr Lys Asp Lys Thr Tyr Ser 145 150 155 160 Phe Gly Asn Ala Pro Val Arg Gly Leu Asp Ile Thr Glu Glu Gly Leu 165 170 175 Gln Ile Val Thr Asp Glu Ser Gly Gly Glu Ser Lys Lys Ile Phe Ala 180 185 190 Asp Lys Thr Tyr Gln Pro Glu Pro Gln Leu Gly Asp Glu Glu Trp His 195 200 205 Asp Thr Ile Gly Ala Glu Asp Lys Tyr Gly Gly Arg Ala Leu Lys Pro 210 215 220 Ala Thr Asn Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys Pro Thr Asn 225 230 235 240 Ala Lys Gly Gly Gln Ala Lys Ser Arg Thr Lys Asp Asp Gly Thr Thr 245 250 255 Glu Pro Asp Ile Asp Met Ala Phe Phe Asp Asp Arg Ser Gln Gln Ala 260 265 270 Ser Phe Ser Pro Glu Leu Val Leu Tyr Thr Glu Asn Val Asp Leu Asp 275 280 285 Thr Pro Asp Thr His Ile Ile Tyr Lys Pro Gly Thr Asp Glu Thr Ser 290 295 300 Ser Ser Phe Asn Leu Gly Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr 305 310 315 320 Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr 325 330 335 Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val 340 345 350 Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu 355 360 365 Asp Ser Leu Gly Asp Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala 370 375 380 Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Val 385 390 395 400 Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asn Gly Val Gly Phe 405 410 415 Thr Asp Ser Phe Gln Gly Ile Lys Val Lys Thr Thr Asn Asn Gly Thr 420 425 430 Ala Asn Ala Thr Glu Trp Glu Ser Asp Thr Ser Val Asn Asn Ala Asn 435 440 445 Glu Ile Ala Lys Gly Asn Pro Phe Ala Met Glu Ile Asn Ile Gln Ala 450 455 460 Asn Leu Trp Arg Asn Phe Leu Tyr Ala Asn Val Ala Leu Tyr Leu Pro 465 470 475 480 Asp Ser Tyr Lys Tyr Thr Pro Ala Asn Ile Thr Leu Pro Thr Asn Thr 485 490 495 Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val Val Ala Pro Ser Leu Val 500 505 510 Asp Ala Tyr Ile Asn Ile Gly Ala Arg Trp Ser Leu Asp Pro Met Asp 515 520 525 Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg 530 535 540 Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val 545 550 555 560 Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu Leu Leu Leu Pro Gly Ser 565 570 575 Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met Ile Leu Gln 580 585 590 Ser Ser Leu Gly Asn Asp Leu Arg Thr Asp Gly Ala Ser Ile Ser Phe 595 600 605 Thr Ser Ile Asn Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr 610 615 620 Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser 625 630 635 640 Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala 645 650 655 Asn Ala Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala 660 665 670 Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser 675 680 685 Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro 690 695 700 Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser 705 710 715 720 Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu 725 730 735 Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr 740 745 750 Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met 755 760 765 Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly 770 775 780 Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser 785 790 795 800 Arg Gln Val Val Asp Glu Val Asn Tyr Lys Asp Tyr Gln Ala Val Thr 805 810 815 Leu Ala Tyr Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro 820 825 830 Thr Met Arg Gln Gly Gln Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu 835 840 845 Ile Gly Lys Ser Ala Val Thr Ser Val Thr Gln Lys Lys Phe Leu Cys 850 855 860 Asp Arg Val Met Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met 865 870 875 880 Gly Ala Leu Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala 885 890 895 His Ala Leu Asp Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr 900 905 910 Leu Leu Tyr Val Val Phe Glu Val Phe Asp Val Val Arg Val His Gln 915 920 925 Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser 930 935 940 Ala Gly Asn Ala Thr Thr 945 950 <210> 113 <211> 209 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 113 Met Met Ala Glu Pro Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile 1 5 10 15 Ile Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys 20 25 30 Arg Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val 35 40 45 Asn Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala 50 55 60 Trp Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe 65 70 75 80 Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu 85 90 95 Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu 100 105 110 Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu 115 120 125 Phe Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro 130 135 140 Met Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly 145 150 155 160 Met Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu 165 170 175 Ala Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe Arg Ser His 180 185 190 Arg Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Gln Asp 195 200 205 Met <210> 114 <211> 797 <212> PRT <213> Artificial Sequence <220> <221> misc_feature <222> (789)..(789) <223> The 'Xaa' at location 789 stands for Ser. <220> <223> Synthetic Construct <400> 114 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ala 1 5 10 15 Ala Asp Glu Asn Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro 20 25 30 Pro Ser Pro Thr Ser Asp Ala Ala Ala Ala Pro Asp Met Gln Glu Met 35 40 45 Glu Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His 50 55 60 Glu Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln 65 70 75 80 Glu Gln Pro Glu Gln Glu Ala Glu Ser Glu Gln Gln Gln Ala Gly Leu 85 90 95 Glu His Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu Ile Lys His 100 105 110 Leu Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Ala 115 120 125 Glu Val Pro Leu Ser Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg Asn 130 135 140 Leu Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys 145 150 155 160 Glu Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu 165 170 175 Ala Leu Ala Thr Tyr His Leu Phe Phe Lys Asn Gln Arg Ile Pro Val 180 185 190 Ser Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Leu Asn Leu Gly 195 200 205 Pro Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro Lys 210 215 220 Ile Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu 225 230 235 240 Gln Gly Ser Gly Glu Glu His Glu His His Ser Ala Leu Val Glu Leu 245 250 255 Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu 260 265 270 Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser 275 280 285 Ala Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu 290 295 300 Glu Glu Met Gln Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val Val 305 310 315 320 Ser Asp Glu Gln Leu Ala Arg Trp Leu Gly Ala Ser Ser Thr Pro Gln 325 330 335 Ser Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr 340 345 350 Val Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu 355 360 365 Arg Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val 370 375 380 Arg Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser 385 390 395 400 Tyr Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His 405 410 415 Thr Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val 420 425 430 Tyr Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln 435 440 445 Gln Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln 450 455 460 Lys Asn Leu Lys Ala Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala 465 470 475 480 Ser Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu 485 490 495 Arg Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe 500 505 510 Arg Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser 515 520 525 Ala Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro 530 535 540 Pro Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala 545 550 555 560 Tyr His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu 565 570 575 Cys His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys 580 585 590 Asn Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu 595 600 605 Gln Gly Pro Gly Asp Gly Lys Gly Gly Leu Lys Leu Thr Pro Gly Leu 610 615 620 Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr His Pro 625 630 635 640 Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys Ala Glu 645 650 655 Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala Gln Leu Gln 660 665 670 Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly His Gly 675 680 685 Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro Ser Phe Pro 690 695 700 Gln Asp Ala Pro Arg Lys Gln Gln Glu Ala Glu Ser Gly Ala Ala Ala 705 710 715 720 Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly Asp Gly 725 730 735 Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln Pro Ala Arg Gln Ser 740 745 750 Gly Arg Arg Gly Gly Gly Gly Gly Arg Gly Arg Ser Ser Arg Arg Gln 755 760 765 Thr Val Val Leu Gly Gly Gly Gly Glu Ser Lys Gln His Gly Tyr His 770 775 780 Leu Arg Ser Gly Xaa Gly Ser Arg Arg Pro Gly Pro Gln 785 790 795 <210> 115 <211> 227 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 115 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr 50 55 60 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Thr Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 116 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 116 Met Ser His Gly Gly Val Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Ala 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Ile Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Arg Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asn His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 117 <211> 176 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 117 Met Gly Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val Leu 1 5 10 15 Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu Glu Lys Ala 20 25 30 Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Val Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Ala His Met Cys Asp Thr Val Met Trp Met Ser Lys Gln Tyr Asp Met 115 120 125 Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Leu Cys Thr Val Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 118 <211> 198 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 118 Met Ala Ser Val Lys Phe Leu Leu Leu Phe Ala Ser Leu Ile Thr Val 1 5 10 15 Ile Ser Asn Glu Lys Leu Thr Ile Tyr Ile Gly Thr Asn His Thr Leu 20 25 30 Glu Gly Ile Pro Lys Ser Ser Trp Tyr Cys Tyr Phe Asp Gln Asp Pro 35 40 45 Asp Leu Thr Ile Glu Leu Cys Gly Asn Asn Gly Gln Asn Thr Ser Ile 50 55 60 His Leu Ile Asn Phe Lys Cys Gly Asp Asp Leu Lys Leu Ile Asn Ile 65 70 75 80 Thr Lys Glu Tyr Gly Gly Met Tyr Tyr Tyr Val Ala Glu Asn Asn Asn 85 90 95 Met Gln Phe Tyr Glu Val Thr Val Thr Asn Pro Thr Thr Pro Arg Thr 100 105 110 Thr Thr Thr Thr Thr Lys Thr Thr Pro Val Thr Thr Met Gln Leu Ala 115 120 125 Thr Asn Asn Ile Phe Ala Met Arg Gln Met Val Asn Asn Ser Thr Gln 130 135 140 Pro Thr Pro Pro Ser Glu Glu Ile Pro Lys Ser Met Ile Gly Ile Ile 145 150 155 160 Val Ala Val Val Val Cys Met Leu Ile Ile Ala Leu Cys Met Val Tyr 165 170 175 Tyr Ala Phe Cys Tyr Arg Lys His Arg Leu Asn Asp Lys Leu Glu His 180 185 190 Leu Leu Ser Val Glu Phe 195 <210> 119 <211> 291 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 119 Met Lys Ala Val Ser Thr Leu Ile Phe Cys Ser Leu Ile Gly Thr Val 1 5 10 15 Phe Ser Val Ser Phe Leu Lys Gln Ile Asn Val Thr Glu Gly Glu Asn 20 25 30 Val Thr Leu Val Gly Val Glu Gly Ala Gln Asn Thr Thr Trp Thr Lys 35 40 45 Tyr His Leu Asp Gly Trp Lys Asp Ile Cys Asn Trp Ser Val Ile Thr 50 55 60 Tyr Thr Cys Glu Gly Val Asn Leu Thr Ile Val Asn Ala Ser Gln Asn 65 70 75 80 Gln Lys Gly Trp Ile Lys Gly Gln Ser Val Ser Val Thr Ser Gln Gly 85 90 95 Tyr Tyr Thr Gln His Thr Leu Ile Tyr Asp Ile Val Val Ile Pro Leu 100 105 110 Pro Thr Pro Ser Pro Pro Ser Thr Thr Thr Gln Thr Thr His Thr Thr 115 120 125 Gln Thr Thr Thr Tyr Ser Thr Ser Asn Gln Pro Thr Thr Thr Thr Ala 130 135 140 Ala Glu Val Ala Ser Ser Ser Gly Val Arg Val Ala Phe Leu Leu Leu 145 150 155 160 Ala Pro Ser Ser Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Asp 165 170 175 Phe Leu Ser Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe 180 185 190 Ser Ser Thr Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro 195 200 205 Ala Thr Thr Pro Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys Gln Thr 210 215 220 Asp Gly Gly Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly Leu 225 230 235 240 Val Ile Leu Ala Val Leu Leu Tyr Tyr Ile Phe Cys Arg Arg Ile Pro 245 250 255 Asn Ala His Arg Lys Pro Ala Tyr Lys Pro Ile Val Ile Gly Gln Pro 260 265 270 Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser Phe 275 280 285 Thr Val Trp 290 <210> 120 <211> 143 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 120 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu Val Leu Pro Arg 1 5 10 15 Pro Val Asp Pro Arg Ser Pro Thr Gln Ser Pro Glu Glu Val Arg Lys 20 25 30 Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys 35 40 45 Ser Asp Met His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile 50 55 60 Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Tyr Phe Asp Phe 65 70 75 80 Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr 85 90 95 Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Pro Gln Pro Arg 100 105 110 Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg Pro 115 120 125 Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 130 135 140 <210> 121 <211> 440 <212> PRT <213> Artificial Sequence <220> <221> misc_feature <222> (163)..(163) <223> The 'Xaa' at location 163 stands for Lys, or Asn. <220> <223> Synthetic Construct <400> 121 Met Ser Lys Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro Val Tyr 1 5 10 15 Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro 20 25 30 Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser 35 40 45 Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu 50 55 60 Lys Leu Gly Glu Gly Val Asp Leu Asp Asp Ser Gly Lys Leu Ile Ser 65 70 75 80 Lys Asn Ala Thr Lys Ala Thr Ala Pro Leu Ser Ile Ser Asn Ser Thr 85 90 95 Ile Ser Leu Asn Met Asp Ala Pro Leu Tyr Asn Asn Asn Gly Lys Leu 100 105 110 Gly Ile Arg Ile Gly Ala Pro Leu Lys Val Val Asp Leu Leu Asn Thr 115 120 125 Leu Ala Val Ala Tyr Gly Ser Gly Leu Gly Leu Lys Asn Asn Ala Leu 130 135 140 Thr Val Gln Leu Val Ser Pro Leu Thr Phe Asp Asn Lys Gly Asn Val 145 150 155 160 Lys Ile Xaa Leu Gly Lys Gly Pro Leu Thr Val Ala Ala Asn Arg Leu 165 170 175 Ser Val Thr Cys Lys Arg Gly Leu Tyr Val Thr Thr Thr Gly Asp Ala 180 185 190 Leu Glu Ser Asn Ile Ser Trp Ala Lys Gly Ile Arg Phe Glu Gly Asn 195 200 205 Ala Ile Ala Ala Asn Ile Gly Lys Gly Leu Glu Phe Gly Thr Thr Ser 210 215 220 Ser Glu Ser Asp Val Ser Asn Ala Tyr Pro Ile Gln Val Lys Leu Gly 225 230 235 240 Thr Gly Leu Thr Phe Asp Ser Thr Gly Ala Ile Val Ala Trp Asn Lys 245 250 255 Glu Asp Asp Lys Leu Thr Leu Trp Thr Thr Ala Asp Pro Ser Pro Asn 260 265 270 Cys Lys Ile Tyr Ser Glu Lys Asp Ala Lys Leu Thr Leu Cys Leu Thr 275 280 285 Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Thr Val Leu Ala Val Asn 290 295 300 Asn Gly Ser Leu Asn Pro Ile Thr Asn Thr Val Ser Thr Ala Ile Val 305 310 315 320 Tyr Leu Lys Phe Asp Ala Asn Gly Val Leu Leu Ser Asn Ser Thr Leu 325 330 335 Asn Lys Glu Tyr Trp Asn Phe Arg Lys Gly Asp Val Thr Pro Ala Glu 340 345 350 Ala Tyr Thr Asn Ala Ile Gly Phe Met Pro Asn Ile Lys Ala Tyr Pro 355 360 365 Lys Asn Thr Ser Ala Ala Ser Lys Ser His Ile Val Gly Gln Val Tyr 370 375 380 Leu Asn Gly Asp Glu Thr Lys Pro Leu Met Leu Ile Ile Thr Phe Asn 385 390 395 400 Glu Thr Asp Asp Ala Thr Cys Thr Tyr Cys Ile Thr Phe Gln Trp Lys 405 410 415 Trp Asp Asn Ser Lys Tyr Thr Gly Glu Thr Leu Ala Thr Ser Ser Phe 420 425 430 Pro Phe Ser Tyr Ile Ala Gln Glu 435 440 <210> 122 <211> 363 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 122 Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 1 5 10 15 Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 20 25 30 His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 35 40 45 Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 50 55 60 Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 65 70 75 80 Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 85 90 95 Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 100 105 110 Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val 115 120 125 Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 130 135 140 Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 145 150 155 160 Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 165 170 175 Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 180 185 190 Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 195 200 205 Ala Ala Asp Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 210 215 220 Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 225 230 235 240 Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 245 250 255 Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 260 265 270 Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 275 280 285 Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 290 295 300 Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 305 310 315 320 Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 325 330 335 Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 340 345 350 Val Gly Gly Pro Gly His Lys Ala Arg Val Leu 355 360 <210> 123 <211> 28800 <212> DNA <213> Artificial Sequence <220> <223> Simian adenovirus A1302 clone <220> <221> CDS <222> (22517)..(23068) <223> 22K <220> <221> CDS <222> (24372)..(24992) <223> E3\CR1-alpha <220> <221> CDS <222> (28360)..(28764) <223> E3\14.7K <400> 123 ggagaaagag gtaatgaaat ggcattatgg gtattatggg tctgcattaa tgaatcggcc 60 agatatcata tgctggccac cgtgcatgtg gcctcgcacc cccgcaagac atggcccgag 120 ttcgagcata acgtcatgac ccgctgcaat gtgcacctgg gctcccgccg aggcatgttc 180 atgccctacc agtgcaacat gcaatttgtg aaggtgctgc tggagcccga tgccatgtcc 240 agagtgagtc tgacgggggt gtttgacatg aatgtggaga tgtggaaaat tctgagatat 300 gatgaatcca agaccaggtg ccgggcctgc gaatgcggag gcaaacacgc caggcttcag 360 cccgtgtgtg tggaggtgac ggaggacctg cgacccgatc atttggtgtt gtcctgcaac 420 gggacggagt tcggctccag cggggaagaa tctgactaga gtgagtagtg tttggggctg 480 ggtgggagcc tgcatgatgg gcagaatgac taaaatctgt gtttttctgc gcagcatcat 540 gagcggaagc gcctcctttg agggaggggt attcagccct tatctgacgg ggcgtctccc 600 ctcctgggcg ggagtgcgtc agaatgtgat gggatccacg gtggacggcc ggcccgtgca 660 gcccgcgaac tcttcaaccc tgacctacgc gaccctgagc tcctcgtccg tagacgcagc 720 tgccgccgca gctgctgctt ccgccgccag cgccgtgcgc ggaatggccc tgggcgccgg 780 ctactacagc tctctggtgg ccaactcgag ttccaccaat aatcccgcca gcctgaacga 840 ggagaagctg ctgctgctga tggcccagct cgaggccctg acccagcgcc tgggcgagct 900 gacccagcag gtggctcagc tgcaggcgga gacgcgggcc gcggttgcca cggtgaaaac 960 caaataaaaa atgaatcaat aaataaacgg agacggttgt tgattttaac acagagtctt 1020 gaatctttat ttgatttttc gcgcgcggta ggccctggac caccggtctc gatcattgag 1080 cacccggtgg attttttcca ggacccggta gaggtgggct tggatgttga ggtacatggg 1140 catgagcccg tcccgggggt ggaggtagct ccattgcagg gcctcgtgct cgggggtggt 1200 gttgtaaatc acccagtcat agcaggggcg cagggcgtgg tgctgcacga tgtccttgag 1260 gaggagactg atggccacgg gcagcccctt ggtgtaggtg ttgacgaacc tgttgagctg 1320 ggagggatgc atgcgggggg agatgagatg catcttggcc tggatcttga gattggcgat 1380 gttcccgccc agatcccgcc gggggttcat gttgtgcagg accaccagca cggtgtatcc 1440 ggtgcacttg gggaatttgt catgcaactt ggaagggaag gcgtgaaaga atttggagac 1500 gcccttgtga ccgcccaggt tttccatgca ctcatccatg atgatggcga tgggcccgtg 1560 ggcggcggcc tgggcaaaga cgtttcgggg gtcggacaca tcgtagttgt ggtcctgggt 1620 gagctcgtca taggccattt taatgaattt ggggcggagg gtgcccgact gggggacaaa 1680 ggtgccctcg atcccggggg cgtagtttcc ctcgcagatc tgcatctccc aggccttgag 1740 ctcggagggg gggatcatgt ccacctgcgg ggcgatgaaa aaaacggttt ccggggcggg 1800 ggagatgagc tgggccgaaa gcaggttccg gagcagctgg gacttgccgc agccggtggg 1860 gccgtagatg accccgatga ccggctgcag gtggtagttg agggagagac agctgccgtc 1920 ctcgcggagg aggggggcca cctcgttcat catctcgcgc acatgcatgt tctcgcgcac 1980 gagttccgcc aggaggcgct cgccccccag cgagaggagc tcttgcagcg aggcgaagtt 2040 tttcagcggt ttgagcccgt cggccatggg cattttggag agggtctgtt gcaagagttc 2100 cagacggtcc cagagctcgg tgatgtgctc tagggcatct cgatccagca gacctcctcg 2160 tttcgcgggt tggggcgact gcgggagtag ggcaccaggc gatgggcgtc cagcgaggcc 2220 agggtccggt ccttccaggg gcgcagggtc cgcgtcagcg tggtctccgt cacggtgaag 2280 gggtgcgcgc cgggctgggc gcttgcgagg gtgcgcttca ggctcatccg gctggtcgag 2340 aaccgctccc ggtcggcgcc ctgcgcgtcg gccaggtagc aattgagcat gagttcgtag 2400 ttgagcgcct cggccgcgtg gcccttggcg cggagcttac ctttggaagt gtgtccgcag 2460 acgggacaga ggagggactt gagggcgtag agcttggggg cgaggaagac ggactcgggg 2520 gcgtaggcgt ccgcgccgca gctggcgcag acggtctcgc actccacgag ccaggtgagg 2580 tcggggcggt cggggtcaaa aacgaggttt cctccgtgct ttttgatgcg tttcttacct 2640 ctggtctcca tgagctcgtg tccccgctgg gtgacaaaga ggctgtccgt gtccccgtag 2700 accgacttta tgggccggtc ctcgagcggg gtgccgcggt cctcgtcgta gaggaacccc 2760 gcccactccg agacgaaggc ccgggtccag gccagcacga aggaggccac gtgggagggg 2820 tagcggtcgt tgtccaccag cgggtccacc ttctccaggg tatgcaagca catgtccccc 2880 tcgtccacat ccaggaaggt gattggcttg taagtgtagg ccacgtgacc gggggtcccg 2940 gccggggggg tataaaaggg ggcgggcccc tgctcgtcct cactgtcttc cggatcgctg 3000 tccaggagcg ccagctgttg gggtaggtat tccctctcga aggcgggcat gacctcggca 3060 ctcaggttgt cagtttctag aaacgaggag gatttgatat tgacggtgcc gttggagacg 3120 cctttcatga gcccctcgtc catctggtca gaaaagacga tctttttgtt gtcgagcttg 3180 gtggcgaagg agccgtagag ggcattggag aggagcttgg cgatggagcg catggtctgg 3240 ttcttttcct tgtcggcgcg ctccttggcg gcgatgttga gctgcacgta ctcgcgcgcc 3300 acgcacttcc attcggggaa gacggtggtg agctcgtcgg gcacgattct gacccgccag 3360 ccgcggttgt gcagggtgat gaggtccacg ctggtggcca cctcgccgcg caggggctcg 3420 ttggtccagc agaggcgccc gcccttgcgc gagcagaagg ggggcagcgg gtccagcatg 3480 agctcgtcgg gggggtcggc gtccacggtg aagatgccgg gcaggagctc ggggtcgaag 3540 tagctgatgc aggtgcccag atcgtccagc gccgcttgcc agtcgcgcac ggccagcgcg 3600 cgctcgtagg ggctgagggg cgtgccccag ggcatggggt gcgtgagcgc ggaggcgtac 3660 atgccgcaga tgtcgtagac gtagaggggc tcctcgagga cgccgatgta ggtggggtag 3720 cagcgccccc cgcggatgct ggcgcgcacg tagtcgtaca gctcgtgcga gggcgcgagg 3780 agccccgcgc cgaggttgga gcgctgcggc ttttcggcgc ggtagacgat ctggcggaag 3840 atggcgtggg agttggagga gatggtgggc ctctggaaga tgttgaagtg ggcgtggggc 3900 aggccgaccg agtccctgat gaagtgggcg taggagtcct gcagcttggc gacgagctcg 3960 gcggtgacga ggacgtccag ggcgcagtag tcgagggtct cttggatgat gtcgtacttg 4020 agctggccct tctgcttcca cagctcgcgg ttgagaagga actcttcgcg gtccttccag 4080 tactcttcga gggggaaccc gtcctgatcg gcacggtaag agcccaccat gtagaactgg 4140 ttgacggcct tgtaggcgca gcagcccttc tccacgggga gggcataagc ttgcgcggcc 4200 ttgcgcaggg aggtgtgggt gagggcgaag gtgtcgcgca ccatgacctt gaggaactgg 4260 tgcttgaagt cgaggtcgtc gcagccgccc tgctcccaga gttggaagtc cgtgcgcttc 4320 ttgtaggcgg ggttgggcaa agcgaaagta acatcgttga agaggatctt gcccgcgcgg 4380 ggcatgaagt tgcgagtgat gcggaaaggc tggggcacct cggcccggtt gttgatgacc 4440 tgggcggcga ggacgatctc gtcgaagccg ttgatgttgt gcccgacgat gtagagttcc 4500 acgaatcgcg ggcggccctt gacgtggggc agcttcttga gctcgtcgta ggtgagctcg 4560 gcggggtcgc tgagtccgtg ctgctcaagg gcccagtcgg cgacgtgggg gttggcgctg 4620 aggaaggaag tccagagatc cacggccagg gcggtttgca agcggtcccg gtactgacgg 4680 aactgctggc ccacggccat tttttcgggg gtgatgcagt agaaggtgcg ggggtcgccg 4740 tgccagcggt cccacttgag ctggagggcg aggtcgtggg cgagctcgac gagcggcggg 4800 tccccggaga gtttcatgac cagcatgaag gggacgagct gcttgccgaa ggaccccatc 4860 caggtgtagg tttccacatc gtaggtgagg aagagccttt cggtgcgagg atgcgagccg 4920 atggggaaga actggatctc ctgccaccag ttggaggaat ggctgttgat gtgatggaag 4980 tagaaatgcc gacggcgcgc cgagcactcg tgcttgtgtt tatacaagcg tccgcagtgc 5040 tcgcaacgct gcacgggatg cacgtgctgc acgagctgta cctgagttcc tttgacgagg 5100 aatttcagtg ggcagtggag cgctggcggc tgcatctggt gctgtactac gtcctggcca 5160 tcggcgtggc catcgtctgc ctcgatggtg gtcatgctga cgagcccgcg cgggaggcag 5220 gtccagacct cgactcggac gggtcggaga gcgaggacga gggcgcgcag gccggagctg 5280 tccagggtcc tgagacgctg cggagtcagg tcagtgggca gcggcggcgc gcggttgact 5340 tgcaggagct tttccagggc gcgcgggagg tccagatggt acttgatctc cacggcgccg 5400 ttggtggcga cgtccacggc ttgcagggtc ccgtgcccct ggggcgccac caccgtgccc 5460 cgtttcttct tgggcgctgg cgttggcgct gcttccatgt cggtcagaag cggcggcgag 5520 gacgcgcgcc gggcggcagg ggcggctcgg ggcccggagg caggggcggc aggggcacgt 5580 cggcgccgcg cgcgggcagg ttctggtact gcgcccggag aagactggcg tgagcgacga 5640 cgcgacggtt gacgtcctgg atctgacgcc tctgggtgaa ggccacggga cccgtgagtt 5700 tgaacctgaa agagagttcg acagaatcaa tctcggtatc gttgacggcg gcctgccgca 5760 ggatctcttg cacgtcgccc gagttgtcct ggtaggcgat ctcggtcatg aactgctcga 5820 tctcctcctc ctgaaggtct ccgcggccgg cgcgctccac ggtggccgcg aggtcgttgg 5880 agatgcggcc catgagctgc gagaaggcgt tcatgcccgc ctcgttccag acgcggctgt 5940 agaccacgac gccctcggga tcgcgggcgc gcatgaccac ctgggcgagg ttgagctcca 6000 cgtggcgcgt gaagaccgcg tagttgcaga ggcgctggta gaggtagttg agcgtggtgg 6060 cgatgtgctc ggtgacgaag aaatacatga tccagcggcg gagcggcatc tcgctgacgt 6120 cgcccagcgc ctccaagcgt tccatggcct cgtaaaagtc cacggcgaag ttgaaaaact 6180 gggagttgcg cgccgagacg gtcaactcct cctccagaag acggatgagc tcggcgatgg 6240 tggcgcgcac ctcgcgctcg aaggcccccg ggagttcctc cacttcctct tcttcttcct 6300 cctccactaa catctcttct acttcctcct caggcggtgg tggcggggga gggggcctgc 6360 gtcgccggcg gcgcacgggc agacggtcga tgaagcgctc gatggtctcg ccgcgccggc 6420 gtcgcatggt ctcggtgacg gcgcgcccgt cctcgcgggg ccgcagcgtg aagacgccgc 6480 cgcgcatctc caggtggccg ggggggtccc cgttgggcag ggagagggcg ctgacgatgc 6540 atcttatcaa ttgccccgta gggactccgc gcaaggacct gagcgtctcg agatccacgg 6600 gatctgaaaa ccgttgaacg aaggcttcga gccagtcgca gtcgcaaggt aggctgagca 6660 cggtttcttc tggcgggtca tgttggttgg agggagcggg gcgggcgatg ctgctggtga 6720 tgaagttgaa ataggcggtt ctgagacggc ggatggtggc gaggagcacc aggtctttgg 6780 gcccggcttg ctggatgcgc agacggtcgg ccatgcccca ggcgtggtcc tgacacctgg 6840 ccaggtcctt gtagtagtcc tgcatgagcc gctccacggg cacctcctcc tcgcccgcgc 6900 ggccgtgcat gcgcgtgagc ccgaacccgc gctgcggctg gacgagcgcc aggtcggcga 6960 cgacgcgctc ggcgaggatg gcctgctgga tctgggtgag ggtggtctgg aagtcgtcaa 7020 agtcgacgaa gcggtggtag gctccggtgt tgatggtgta ggagcagttg gccatgacgg 7080 accagttgac ggtctggtgg cccggacgca cgagctcgtg gtacttgagg cgcgagtagg 7140 cgcgcgtgtc gaagatgtag tcgttgcagg tgcgcaccag gtattggtag ccgatgagga 7200 agtgcggcgg cggctggcgg tagagcggcc atcgctcggt ggcgggggcg ccgggcgcga 7260 ggtcctcgag catgaggcgg tggtagccgt agatgtacct ggacatccag gtgatgccgg 7320 cggcggtggt ggaggcgcgc gggaactcgc ggacgcggtt ccagatgttg cgcagcggca 7380 ggaagtagtt catggtggcc gcggtctggc ccgtgaggcg cgcgcagtcg tggatgctct 7440 agacatacgg gcaaaaacga aagcggtcag cggctcgact ccgtggcctg gaggctaagc 7500 gaacgggttg ggctgcgcgt gtaccccggt tcgaatctcg aatcaggctg gagccgcagc 7560 taacgtggta ctggcactcc cgtctcgacc caagcctgct aacgaaacct ccaggatacg 7620 gaggcgggtc gttttggcat ttttcgtcag gccggaaatg aaactagtaa gcgcggaaag 7680 cggccgaccg cgatggctcg ctgccgtagt ctggagaaga atcgccaggg ttgcgttgcg 7740 gtgtgccccg gttcgaggcc ggccggattc cgcggctaac gagggcgtgg ctgccccgtc 7800 gtttccaaga cccctagcca gccgacttct ccagttacgg agcgagcccc tcttttgttt 7860 tttgtttttg ccagatgcat cccgtactgc ggcagatgcg cccccaccac cctccaccgc 7920 aacaacagcc ccctccacag ccggcgcttc tgcccccgcc ccagcagcag cagcaacttc 7980 cagccacgac cgccgcggcc gccgtgagcg gggctggaca gagttatgac caccagctgg 8040 ccttggaaga gggcgagggg ctggcgcggc tgggggcgtc gtcgccggag cggcacccgc 8100 gcgtgcagat gaaaagggac gctcgcgagg cctacgtgcc caagcagaac ctgttcagag 8160 acaggagcgg cgaggagccc gaggagatgc gcgcctcccg cttccacgcg gggcgggagc 8220 tgcggcgcgg cctggaccga aagcgggtgc tgagggacga ggatttcgag gcggacgagc 8280 tgacggggat cagccccgcg cgcgcgcacg tggccgcggc caacctggtc acggcgtacg 8340 agcagaccgt gaaggaggag agcaacttcc aaaaatcctt caacaaccac gtgcgcacct 8400 tgatcgcgcg cgaggaggtg accctgggcc tgatgcacct gtgggacctg ctggaggcca 8460 tcgtgcagaa ccccacgagc aagccgctga cggcgcagct gtttctggtg gtgcagcaca 8520 gtcgggacaa cgagacgttc agggaggcgc tgctgaatat caccgagccc gagggccgtt 8580 ggctcctgga cctggtgaac attctgcaga gcatcgtggt gcaggagcgc gggctgccgc 8640 tgtccgagaa gctggcggcc atcaacttct cggtgctgag cctgggcaag tactacgcta 8700 ggaagatcta caagaccccg tacgtgccca tagacaagga ggtgaagatc gatgggtttt 8760 acatgcgcat gaccctgaaa gtgctgaccc tgagcgacga tctgggggtg taccgcaacg 8820 acaggatgca ccgcgcggtg agcgccagcc gccggcgcga gctgagcgac caggagctga 8880 tgcacagcct gcagcgggcc ctgaccgggg ccgggaccga gggggagagc tactttgaca 8940 tgggcgcgga cctgcgctgg cagcccagcc gccgggcctt ggaagctgcc ggcggcgtgc 9000 cctacgtgga ggaggtggac gatgaggagg aggagggcga gtacctggaa gactgatggc 9060 gcgaccgtat ttttgctaga tgcagcaaca gccaccgcct cctgatcccg cgatgcgggc 9120 ggcgctgcag agccagccgt ccggcattaa ctcctcggac gattggaccc aggccatgca 9180 acgcatcatg gcgctgacga cccgcaatcc cgaagccttt agacagcagc ctcaggccaa 9240 ccggctctcg gccatcctgg aggccgtggt gccctcgcgc tcgaacccca cgcacgagaa 9300 ggtgctggcc atcgtgaacg cgctggtgga gaacaaggcc atccgcggcg acgaggccgg 9360 gctggtgtac aacgcgctgc tggagcgcgt ggcccgctac aacagcacca acgtgcagac 9420 gaacctggac cgcatggtga ccgacgtgcg cgaggcggtg tcgcagcgcg agcggttcca 9480 ccgcgagtcg aacctgggct ccatggtggc gctgaacgcc ttcctgagca cgcagcccgc 9540 caacgtgccc cggggccagg aggactacac caacttcatc agcgcgctgc ggctgatggt 9600 ggccgaggtg ccccagagcg aggtgtacca gtcggggccg gactacttct tccagaccag 9660 tcgccagggc ttgcagaccg tgaacctgag ccaggctttc aagaacttgc agggactgtg 9720 gggcgtgcag gccccggtcg gggaccgcgc gacggtgtcg agcctgctga cgccgaactc 9780 gcgcctgctg ctgctgctgg tggcgccctt cacggacagc ggcagcgtga gccgcgactc 9840 gtacctgggc tacctgctta acctgtaccg cgaggccatc gggcaggcgc acgtggacga 9900 gcagacctac caggagatca cccacgtgag ccgcgcgctg gggcaggagg acccgggcaa 9960 cctggaggcc accctgaact tcctgctgac caaccggtcg cagaagatcc cgccccagta 10020 cgcgctgagc accgaggagg agcgcatcct gcgctacgtg cagcagagcg tggggctgtt 10080 cctgatgcag gagggggcca cgcccagcgc cgcgctcgac atgaccgcgc gcaacatgga 10140 gcccagcatg tacgcccgca accgcccgtt catcaataag ctgatggact acttgcatcg 10200 ggcggccgcc atgaactcgg actactttac caacgccatc ttgaacccgc actggctccc 10260 gccgcccggg ttctacacgg gcgagtacga catgcccgac cccaacgacg ggttcctgtg 10320 ggacgacgtg gacagcagcg tgttctcgcc gcgccccacc accaccgtgt ggaagaaaga 10380 gggcggggac cggcggccgt cctcggcgct gtccggtcgc gcgggtgctg ccgcggcggt 10440 gcccgaggcc gccagcccct tcccgagcct gcccttttcg ctgaacagcg tgcgcagcag 10500 cgagctgggt cggctgacgc ggccgcgcct gctgggcgag gaggagtacc tgaacgactc 10560 cttgttgagg cccgagcgcg agaaaaactt ccccaataac gggatagaga gcctggtgga 10620 caagatgagc cgctggaaga cgtacgcgca cgagcacagg gacgagcccc gagctagcag 10680 cagcaccggc gcccgtagac gccagcggca cgacaggcag cggggactgg tgtgggacga 10740 tgaggattcc gccgacgaca gcagcgtgtt ggacttgggt gggagtggtg gtggtaaccc 10800 gttcgctcac ctgcgccccc gtatcgggcg cctgatgtaa gaatctgaaa aaataaaaaa 10860 acggtactca ccaaggccat ggcgaccagc gtgcgttctt ctctgttgtt tgtagtagta 10920 tgatgaggcg cgtgtacccg gagggtcctc ctccctcgta cgagagcgtg atgcagcagg 10980 cggtggcggc ggcgatgcag cccccgctgg aggcgcctta cgtgcccccg cggtacctgg 11040 cgcctacgga ggggcggaac agcattcgtt actcggagct ggcacccttg tacgatacca 11100 cccggttgta cctggtggac aacaagtcgg cggacatcgc ctcgctgaac taccagaacg 11160 accacagcaa cttcctgacc accgtggtgc agaacaacga tttcaccccc acggaggcca 11220 gcacccagac catcaacttt gacgagcgct cgcggtgggg cggccagctg aaaaccatca 11280 tgcacaccaa catgcccaac gtgaacgagt tcatgtacag caacaagttc aaggcgcggg 11340 tgatggtctc gcgcaagacc cccaacgggg tcacagtaac agatggtagt caggacgagc 11400 tgacctacga gtgggtggag tttgagctgc ccgagggcaa cttctcggtg accatgacca 11460 tcgatctgat gaacaacgcc atcatcgaca actacttggc ggtgggacgg cagaacgggg 11520 tgctggagag cgacatcggc gtgaagttcg acacgcgcaa cttccggctg ggctgggacc 11580 ccgtgaccga gctggtgatg ccgggcgtgt acaccaacga ggccttccac cccgacattg 11640 tcctgctgcc cggctgcggc gtggacttca ccgagagccg cctcagcaac ctgctgggca 11700 tccgcaagcg gcagcccttc caggagggct tccagatcct gtacgaggac ctggaggggg 11760 gcaacatccc cgcgctgctg gacgtggacg cctacgagaa aagcaaggag gagagcgccg 11820 ccgcggcgac cgcagccgtg gccaccgcct ctaccgaggt gcggggcgat aattttgcta 11880 gcgccgcggc agtggccgag gcggctgaaa ccgaaagtaa gatagtgatc cagccggtgg 11940 agaaggacag caaggacagg agctacaacg tgctcgcgga caagaaaaac accgcctacc 12000 gcagctggta cctggcctac aactacggcg accccgagaa gggcgtgcgc tcctggacgc 12060 tgctcaccac ctcggacgtc acctgcggcg tggagcaagt ctactggtcg ctgcccgaca 12120 tgatgcaaga cccggtcacc ttccgctcca cgcgacaagt tagcaactac ccggtggtgg 12180 gcgccgagct cctgcccgtc tactccaaga gcttcttcaa cgagcaggcc gtctactcgc 12240 agcagctgcg cgccttcacc tcgctcacgc acgtcttcaa ccgcttcccc gagaaccaga 12300 tcctcgtccg cccgcccgcg cccaccatta ccaccgtcag tgaaaacgtt cctgctctca 12360 cagatcacgg gaccctgccg ctgcgcagca gtatccgggg agtccagcgc gtgaccgtca 12420 ctgacgccag acgccgcacc tgcccctacg tctacaaggc cctgggcgta gtcgcgccgc 12480 gcgtcctctc gagccgcacc ttctaaaaaa tgtccattct catctcgccc agtaataaca 12540 ccggttgggg cctgcgcgcg cccagcaaga tgtacggagg cgctcgccaa cgctccacgc 12600 aacaccccgt gcgcgtgcgc gggcacttcc gcgctccctg gggcgccctc aagggtcgcg 12660 tgcgctcgcg caccaccgtc gacgacgtga tcgaccaggt ggtggccgac gcgcgcaact 12720 acacgcccgc cgccgcgccc gcctccaccg tggacgccgt catcgacagc gtggtggccg 12780 acgcgcgccg gtacgcccgc gccaagagcc ggcggcggcg catcgcccgg cggcaccgga 12840 gcacccccgc catgcgcgcg gcgcgagcct tgctgcgcag ggccaggcgc acgggacgca 12900 gggccatgct cagggcggcc agacgcgcgg cctccggcag cagcagcgcc ggcaggaccc 12960 gcagacgcgc ggccacggcg gcggcggcgg ccatcgccag catgtcccgc ccgcggcgcg 13020 gcaacgtgta ctgggtgcgc gacgccgcca ccggtgtgcg cgtgcccgtg cgcacccgcc 13080 cccctcgcac ttgaagatgc tgacttcgcg atgttgatgt gtcccagcgg cgaggaggat 13140 gtccaagcgc aaattcaagg aagagatgct ccaggtcatc gcgcctgaga tctacggccc 13200 cgcggcggcg gtgaaggagg aaagaaagcc ccgcaaactg aagcgggtca aaaaggacaa 13260 aaaggaagaa gatgtggacg atatggtgga gtttgtgcgc gagttcgccc cccggcggcg 13320 cgtgcagtgg cgcgggcgga aggtgcgccc ggtgctgaga cccggcacca cggtggtctt 13380 cacgcccgga gagcgctctg gcaccgcctc caagcgctcc tacgacgagg tgtacgggga 13440 tgatgatatt ctggagcagg cggccgagcg cctgggcgag tttgcttacg gcaagcgcag 13500 ccgccccgcg cccttgaaag aggaggcggt gtccatcccg ctggaccacg gcaaccccac 13560 gccgagcctg aagccggtga ccctgcagca ggtgctgcca gccgcggcgc cgcgccgggg 13620 gttcaagcgc gagggcgagg atctgtaccc caccatgcag ctgatggtgc ccaagcgcca 13680 gaagctggag gacgtgctgg agcacatgaa ggtggacccg gacgtgcagc ccgaggtcaa 13740 ggtgcggccc atcaagcagg tggccccggg cctgggcgtg cagaccgtgg acatcaagat 13800 ccccacggag cccatggaaa cgcagactga gcccgtgaag cccagcacca gcaccatgga 13860 ggtgcagacg gatccctgga tgccagcggc ttccaccacc actcgccgaa gacgcaagta 13920 cggcgcggcc agcctgctga tgcccaacta cgcgctgcat ccttccatca tccccacgcc 13980 gggctaccgc ggcacgcgct tctaccgcgg ctacaccagc agccgccgcc gcaagaccac 14040 cacccgccgc cgccgtcgtc gcagccgccg cagcagcacc gcgacttccg ccttggtgcg 14100 gagagtgtac cgcagcgggc gcgagcctct gaccctgccg cgcgcgcgct accacccgag 14160 catcgccatt taactaccgc ctcctacttg cagatatggc cctcacatgc cgcctccgcg 14220 tccccattac gggctaccga ggaagaaagc cgcgccgtag aaggctgacg gggaacgggc 14280 tgcgtcgcca tcaccaccgg cggcggcgcg ccatcagcaa gcggttgggg ggaggcttcc 14340 tgcccgcgct gatccccatc atcgccgcgg cgatcggggc gatccccggc atagcttccg 14400 tggcggtgca ggcctctcag cgccactgag acacagcttg gaaaatttgt aataaaaaat 14460 ggactgacgc tcctggtcct gtgatgtgtg tttttagatg gaagacatca atttttcgtc 14520 cctggcaccg cgacacggca cgcggccgtt tatgggcacc tggagcgaca tcggcaacag 14580 ccaactgaac gggggcgcct tcaattggag cagtctctgg agcgggctta agaatttcgg 14640 gtccacgctc aaaacctatg gcaacaaggc gtggaacagc agcacagggc aggcgctgag 14700 ggaaaagctg aaagagcaga acttccagca gaaggtggtc gatggcctgg cctcgggcat 14760 caacggggtg gtggacctgg ccaaccaggc cgtgcagaaa cagatcaaca gccgcctgga 14820 cgcggtcccg cccgcggggt ccgtggacat gccccaggtg gaggaggagc tgcctcccct 14880 ggacaagcgc ggcgacaagc gaccgcgtcc cgacgctgag gagacgctgc tgacgcacac 14940 ggacgagccg cccccgtacg aggaggcggt gaaactgggt ctgcccacca cgcggcccgt 15000 ggcgcctctg gccaccgggg tgctgaaacc cagcagcagc agcagccagc ccgcgaccct 15060 ggacttgcct ccacctcgcc cctccacagt ggctaagccc ctgccgccgg tggccgtcgc 15120 gtcgcgcgcc ccccgaggcc gcccccaggc gaactggcag agcactctga acagcatcgt 15180 gggtctggga gtgcagagtg tgaagcgccg ccgctgctat taaaagacac tgtagcgctt 15240 aacttgcttg tctgtgtgtg tatatgtatg tccgccgacc agaaggagga agaggcgcgt 15300 cgccgagttg caagatggcc accccatcga tgctgcccca gtgggcgtac atgcacatcg 15360 ccggacagga cgcttcggag tacctgagtc cgggtctggt gcagttcgcc cgcgccacag 15420 acacctactt cagtctgggg aacaagttta ggaaccccac ggtggcgccc acgcacgatg 15480 tgaccaccga ccgcagccag cggctgacgc tgcgcttcgt gcccgtggac cgcgaggaca 15540 acacctactc gtacaaagtg cgctacacgc tggccgtggg cgacaaccgc gtgctggaca 15600 tggccagcac ctactttgac atccgcggcg tgctggatcg gggccccagc ttcaaaccct 15660 actccggcac cgcctacaac agcctggctc ccaagggagc gcccaacacc tcacaatgga 15720 taaccaaaga caagacatac agttttggaa atgctccagt cagaggattg gacattacag 15780 aagagggtct ccaaatagta accgatgagt cagggggtga aagcaagaaa atttttgcag 15840 acaaaaccta tcagcctgaa cctcagcttg gagatgagga atggcatgat actattggag 15900 ctgaagacaa gtatggaggc agagcgctta aacctgccac caacatgaaa ccctgctatg 15960 ggtctttcgc caagccaact aatgctaagg gaggtcaggc taaaagcaga accaaggacg 16020 atggcactac tgagcctgat attgacatgg ccttttttga cgatcgcagt cagcaagcta 16080 gtttcagtcc agaacttgtt ttgtatactg agaatgtcga tctggacacc ccggataccc 16140 acattattta caaacctggc actgatgaaa caagttcttc tttcaacttg ggtcagcagt 16200 ccatgcccaa cagacccaat tacattggct tcagagacaa ctttatcgga ctcatgtact 16260 acaacagcac tggcaatatg ggtgtactgg ctggacaggc ctcccagctg aatgctgtgg 16320 tggacttgca ggacagaaac accgaactgt cctaccagct cttgcttgac tctctgggcg 16380 acagaaccag gtatttcagt atgtggaatc aggcggtgga cagctatgac cccgatgtgc 16440 gcattattga aaatcacggt gtggaggatg aacttcccaa ctattgcttc cctttgaatg 16500 gtgtgggctt tacagattca ttccagggaa ttaaggttaa aactaccaat aacggaacag 16560 caaacgctac agagtgggaa tctgatacct ctgtcaataa tgctaatgag attgccaagg 16620 gcaatccttt cgccatggag atcaacatcc aggccaacct gtggcggaac ttcctctacg 16680 cgaacgtggc gctgtacctg cccgactcct acaagtacac gccggccaac atcacgctgc 16740 ccaccaacac caacacctac gattacatga acggccgcgt ggtggcgccc tcgctggtgg 16800 acgcctacat caacatcggg gcgcgctggt cgctggaccc catggacaac gtcaacccct 16860 tcaaccacca ccgcaacgcg ggcctgcgat accgctccat gctcctgggc aacgggcgct 16920 acgtgccctt ccacatccag gtgccccaaa agtttttcgc catcaagagc ctcctgctcc 16980 tgcccgggtc ctacacctac gagtggaact tccgcaagga cgtcaacatg atcctgcaga 17040 gctccctcgg caacgacctg cgcacggacg gggcctccat ctccttcacc agcatcaacc 17100 tctacgccac cttcttcccc atggcgcaca acacggcctc cacgctcgag gccatgctgc 17160 gcaacgacac caacgaccag tccttcaacg actacctctc ggcggccaac atgctctacc 17220 ccatcccggc caacgccacc aacgtgccca tctccatccc ctcgcgcaac tgggccgcct 17280 tccgcggctg gtccttcacg cgtctcaaga ccaaggagac gccctcgctg ggctccgggt 17340 tcgaccccta cttcgtctac tcgggctcca tcccctacct cgacggcacc ttctacctca 17400 accacacctt caagaaggtc tccatcacct tcgactcctc cgtcagctgg cccggcaacg 17460 accgcctcct gacgcccaac gagttcgaaa tcaagcgcac cgtcgacgga gaggggtaca 17520 acgtggccca gtgcaacatg accaaggact ggttcctggt ccagatgctg gcccactaca 17580 acatcggcta ccagggcttc tacgtgcccg agggctacaa ggaccgcatg tactccttct 17640 tccgcaactt ccagcccatg agccgccagg tcgtggacga ggtcaactac aaggactacc 17700 aggccgtcac cctggcctac cagcacaaca actcgggctt cgtcggctac ctcgcgccca 17760 ccatgcgcca ggggcagccc taccccgcca actacccgta cccgctcatc ggcaagagcg 17820 ccgtcaccag cgtcacccag aaaaagttcc tctgcgaccg ggtcatgtgg cgcatcccct 17880 tctccagcaa cttcatgtcc atgggcgcgc tcaccgacct cggccagaac atgctctatg 17940 ccaactccgc ccacgcgcta gacatgaatt tcgaagtcga ccccatggat gagtccaccc 18000 ttctctatgt tgtcttcgaa gtcttcgacg tcgtccgagt gcaccagccc caccgcggcg 18060 tcatcgaggc cgtctacctg cgcaccccct tctcggccgg taacgccacc acctaagctc 18120 ttgcttcttg catgatggct gagcccacgg gctccggcga gcaggagctc agggccatca 18180 tccgcgacct gggctgcggg ccctacttcc tgggcacctt cgataagcgc ttcccgggat 18240 tcatggcccc gcacaagctg gcctgcgcca tcgtcaacac ggccggtcgc gagaccgggg 18300 gcgagcactg gctggccttc gcctggaacc cgcgctcgaa cacctgctac ctcttcgacc 18360 ccttcgggtt ctcggacgag cgcctcaagc agatctacca gttcgagtac gagggcctgc 18420 tgcgccgcag cgccctggcc accgaggacc gctgcgtcac cctggaaaag tccacccaga 18480 ccgtgcaggg tccgcgctcg gccgcctgcg ggctcttctg ctgcatgttc ctgcacgcct 18540 tcgtgcactg gcccgaccgc cccatggaca agaaccccac catgaacttg ctgacggggg 18600 tgcccaacgg catgctccag tcgccccagg tggaacccac cctgcgccgc aaccaggagg 18660 cgctctaccg cttcctcaac gcccactccg cctactttcg ctcccaccgc gcgcgcatcg 18720 agaaggccac cgccttcgac cgcatgaatc aagacatgta aaccgtgtgt gtatgtgaat 18780 gctttattca taataaacag cacatgttta tgccaccttc tctgaggctc tgactttatt 18840 tagaaatcga aggggttctg ccggctctcg gcgtgccccg cgggcaggga tacgttgcgg 18900 aactggtact tgggcagcca cttgaactcg gggatcagca gcttcggcac ggggaggtcg 18960 gggaacgagt cgctccacag cttgcgcgtg agttgcaggg cgcccagcag gtcgggcgcg 19020 gagatcttga aatcgcagtt gggacccgcg ttctgcgcgc gagagttgcg gtacacgggg 19080 ttgcagcact ggaacaccat cagggccggg tgcttcacgc tcgccagcac cgtcgcgtcg 19140 gtgatgccct ccacgtccag atcctcggcg ttggccatcc cgaagggggt catcttgcag 19200 gtctgccgcc ccatgctggg cacgcagccg ggcttgtggt tgcaatcgca gtgcaggggg 19260 atcagcatca tctgggcctg ctcggagctc atgcccgggt acatggcctt catgaaagcc 19320 tccagctggc ggaaggcctg ctgcgccttg ccgccctcgg tgaagaagac cccgcaggac 19380 ttgctagaga actggttggt agcgcagccc gcgtcgtgca cgcagcagcg cgcgtcgttg 19440 ttggccagct gcaccacgct gcgcccccag cggttctggg tgatcttggc ccggtcgggg 19500 ttctccttca gcgcgcgctg cccgttctcg ctcgccacat ccatctcgat cgtgtgctcc 19560 ttctggatca tcacggtccc gtgcaggcac cgcagcttgc cctcggcctc ggtgcagccg 19620 tgcagccaca gcgcgcagcc ggtgctctcc cagttcttgt gggcgatctg ggagtgcgag 19680 tgcacgaagc cctgcaggaa gcggcccatc atcgcggtca gggtcttgtt gctggtgaag 19740 gtcagcggga tgccgcggtg ctcctcgttc acatacaggt ggcagatgcg gcggtacacc 19800 tcgccctgct cgggcatcag ctggaaggcg gacttcaggt cgctctccac gcggtaccgc 19860 tccatcagca gcgtcatcac ttccatgccc ttctcccagg ccgaaacgat cggcaggctc 19920 agggggttct tcaccgtcat cttagtcgcc gccgccgagg tcagggggtc gttctcgtcc 19980 agggtctcaa acactcgctt gccgtccttc tcggtgatgc gcacgggggg gaaggcgaag 20040 cccacggccg ccagctcctc ctcggcctgc ctttcgtcct cgctgtcctg gctgatgtct 20100 tgcaaaggca catgcttggt cttgcggggt ttctttttgg gcggcagagg cggcggcgga 20160 gacgtgctgg gcgagcgcga gttctcgctc accacgacta tttcttcttc ttggccgtcg 20220 tccgagacca cgcggcggta ggcatgcctc ttctggggca gaggcggagg cgacgggctc 20280 tcgcggttcg acgggcggct ggcagagccc cttccgcgtt cgggggtgcg ctcctggcgg 20340 cgctgctctg actgacttcc tccgcggccg gccattgtgt tctcctaggg agcaacaagc 20400 atggagactc agccatcgtc gccaacatcg ccatctgccc ccgccgccgc cgacgagaac 20460 cagcagcagc agaatgaaag cttaaccgcc ccgccgccca gccccacctc cgacgccgcc 20520 gcagccccag acatgcaaga gatggaggaa tccatcgaga ttgacctggg ctacgtgacg 20580 cccgcggagc acgaggagga gctggcagcg cgcttttcag ccccggaaga gaaccaccaa 20640 gagcagccag agcaggaagc agagagcgag cagcagcagg ctgggctcga gcatggcgac 20700 tacctgagcg gggcagagga cgtgctcatc aagcatctgg cccgccaatg catcatcgtc 20760 aaggacgcgc tgctcgaccg cgccgaggtg cccctcagcg tggcggagct cagccgcgcc 20820 tacgagcgca acctcttctc gccgcgcgtg ccccccaagc gccagcccaa cggcacctgc 20880 gagcccaacc cgcgcctcaa cttctacccg gtcttcgcgg tgcccgaggc cctggccacc 20940 taccacctct ttttcaagaa ccaaaggatc cccgtctcct gccgcgccaa ccgcacccgc 21000 gccgacgccc tgctcaacct gggccccggc gcccgcctac ctgatatcgc ctccttggaa 21060 gaggttccca agatcttcga gggtctgggc agcgacgaga ctcgggccgc gaacgctctg 21120 caaggaagcg gagaggagca tgagcaccac agcgccctgg tggagttgga aggcgacaac 21180 gcgcgcctgg cggtcctcaa gcgcacggtc gagctgaccc acttcgccta cccagcgctc 21240 aacctgcccc ccaaggtcat gagcgccgtc atggaccagg tgctcatcaa gcgcgcctcg 21300 cccctctcgg aggaggagat gcaggacccc gagagctcgg acgagggcaa gcccgtggtc 21360 agcgacgagc agctggcgcg ctggctggga gcgagtagca ccccccagag cctggaagag 21420 cggcgcaagc tcatgatggc cgtggtcctg gtgaccgtgg agctggagtg tctgcgccgc 21480 ttctttgccg acgcggagac cctgcgcaag gtcgaggaga acctgcacta cctcttcagg 21540 cacgggttcg tgcgccaggc ctgcaagatc tccaacgtgg agctgaccaa cctggtctcc 21600 tacatgggca tcctgcacga gaaccgcctg gggcagaacg tgctgcacac caccctgcgc 21660 ggggaggccc gccgcgacta catccgcgac tgcgtctacc tgtacctctg ccacacctgg 21720 cagacgggca tgggcgtgtg gcagcagtgc ctggaggagc agaacctgaa agagctctgc 21780 aagctcctgc agaagaacct caaggccctg tggaccgggt tcgacgagcg caccaccgcc 21840 tcggacctgg ccgacctcat cttccccgag cgcctgcggc tgacgctgcg caacgggctg 21900 cccgacttta tgagccaaag catgttgcaa aactttcgct ctttcatcct cgaacgctcc 21960 gggatcctgc ccgccacctg ctccgcactg ccctcggact tcgtgccgct gaccttccgc 22020 gagtgccccc cgccgctctg gagccactgc tacctgctgc gcctggccaa ctacctggcc 22080 taccactcgg acgtgatcga ggacgtcagc ggcgagggtc tgctcgagtg ccactgccgc 22140 tgcaacctct gcacgccgca ccgctccctg gcctgcaacc cccagctgct gagcgagacc 22200 cagatcatcg gcaccttcga gttgcaaggg cccggtgacg gcaagggggg tctgaaactc 22260 accccggggc tgtggacctc ggcctacttg cgcaagttcg tgcccgagga ctaccatccc 22320 ttcgagatca ggttctacga ggaccaatcc cagccgccca aggccgagct gtcggcctgc 22380 gtcatcaccc agggggccat cctggcccaa ttgcaagcca tccagaaatc ccgccaagaa 22440 tttctgctga aaaagggcca cggggtctac ctggaccccc agaccggaga ggagctcaac 22500 cccagcttcc cccagg atg ccc cga gga agc agc aag aag ctg aaa gtg gag 22552 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu 1 5 10 ctg ccg ccg gag gat ttg gag gaa gac tgg gag agc agt cag gca gag 22600 Leu Pro Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu 15 20 25 gag atg gaa gac tgg gac agc act cag gca gag gag gac agc ctg caa 22648 Glu Met Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln 30 35 40 gac agt ctg gaa gac gag gtg gag gag gag gca gag gaa gaa gca gcc 22696 Asp Ser Leu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala Ala 45 50 55 60 gcc gcc aga ccg tcg tcc tcg gcg gag gag gag aaa gca agc agc acg 22744 Ala Ala Arg Pro Ser Ser Ser Ala Glu Glu Glu Lys Ala Ser Ser Thr 65 70 75 gat acc atc tcc gct ccg ggt crg ggt cgc ggc ggc cgg gcc cac agt 22792 Asp Thr Ile Ser Ala Pro Gly Xaa Gly Arg Gly Gly Arg Ala His Ser 80 85 90 agg tgg gac gag acc ggg cgc ttc ccg aac ccc acc acc cag acc ggt 22840 Arg Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly 95 100 105 aag aag gag cgg cag gga tac aag tcc tgg cgg ggg cac aaa aac gcc 22888 Lys Lys Glu Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala 110 115 120 atc gtc tcc tgc ttg caa gcc tgc ggg ggc aac atc tcc ttc acc cgg 22936 Ile Val Ser Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg 125 130 135 140 cgc tac ctg ctc ttc cac cgc ggg gtg aac ttc ccc cgc aac atc ttg 22984 Arg Tyr Leu Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu 145 150 155 cat tac tac cgt cac ctc cac agc ccc tac tac tgt ttc caa gaa gag 23032 His Tyr Tyr Arg His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu 160 165 170 gca gaa acc cag cag cag cag aaa acc agc ggc agc tagaaaatcc 23078 Ala Glu Thr Gln Gln Gln Gln Lys Thr Ser Gly Ser 175 180 acagcggcgg cggcaggtgg actgaggatc gcggcgaacg agccggcgca gacccgggag 23138 ctgaggaacc ggatctttcc caccctctat gccatcttcc agcagagtcg ggggcaggag 23198 caggaactga aagtcaagaa ccgttctctg cgctcgctca cccgcagttg tctgtatcac 23258 aagagcgaag accaacttca gcgcactctc gaggacgccg aggctctctt caacaagtac 23318 tgcgcgctca ctcttaaaga gtagcccgcg cccgcccaca cacggaaaaa ggcgggaatt 23378 acgtcaccac ctgcgccctt cgcccgacca tcatcatgag caaagagatt cccacgcctt 23438 acatgtggag ctaccagccc cagatgggcc tggccgccgg cgccgcccag gactactcca 23498 cccgcatgaa ctggctcagt gccgggcccg cgatgatctc acgggtgaat gacatccgcg 23558 cccaccgaaa ccagatactc ctagaacagt cagcgatcac cgccacgccc cgccatcacc 23618 ttaatccgcg taattggccc gccgccctgg tgtaccagga aattccccag cccacgaccg 23678 tactacttcc gcgagacgcc caggccgaag tccagctgac taactcaggt gtccagctgg 23738 ccggcggcgc caccctgtgt cgtcaccgcc ccgctcaggg tataaagcgg ctggtgatcc 23798 gaggcagagg cacacagctc aacgacgagg tggtgagctc ttcgctgggt ctgcgacctg 23858 acggagtctt ccaactcgcc ggatcgggga gatcttcctt cacgcctcgt caggccgtcc 23918 tgactttgga gagttcgtcc tcacagcccc gctcgggcgg catcggcact ctccagttcg 23978 tggaggagtt cactccctcg gtctacttca accccttctc cggctccccc ggccactacc 24038 cggacgagtt catcccgaac ttcgacgcca tcagcgagtc ggtggacggc tacgattgaa 24098 tgtcccatgg tggcgtggct gacctagctc ggcttcgaca cctggaccac tgccgccgct 24158 tccgctgctt cgctcgggat ctcgccgagt ttgcctactt tgagctgccc gaggagcacc 24218 ctcagggccc ggcccacgga gtgcggatca tcgtcgaagg gggtctcgac tcccacctgc 24278 ttcggatctt cagccagcga ccgatcctgg tcgagcgcga gcaaggacag acccgtctga 24338 ccctgtactg catctgcaac caccccggcc tgc atg aaa gtc ttt gtt gtc tgc 24392 Met Lys Val Phe Val Val Cys 185 190 tgt gta ctg agt ata ata aaa gct gag atc agc gac tac tcc gga ctc 24440 Cys Val Leu Ser Ile Ile Lys Ala Glu Ile Ser Asp Tyr Ser Gly Leu 195 200 205 gat tgt ggt gtt cct gct atc aac cag tcc ctg ttc ttc acc ggg aac 24488 Asp Cys Gly Val Pro Ala Ile Asn Gln Ser Leu Phe Phe Thr Gly Asn 210 215 220 gag acc gag ctc cag ctc cag tgt aag ccc cac aag aag tat ctc acc 24536 Glu Thr Glu Leu Gln Leu Gln Cys Lys Pro His Lys Lys Tyr Leu Thr 225 230 235 tgg ctg ttc cag ggc tcc ccg atc gcc gtt gtc aac cac tgc gac aac 24584 Trp Leu Phe Gln Gly Ser Pro Ile Ala Val Val Asn His Cys Asp Asn 240 245 250 255 gac gga gtc ctg ctg agc ggc cct gcc aac ctt act ttt tcc acc cgc 24632 Asp Gly Val Leu Leu Ser Gly Pro Ala Asn Leu Thr Phe Ser Thr Arg 260 265 270 aga agc aag ctc cag ctc ttc caa ccc ttc ctc ccc ggg acc tat cag 24680 Arg Ser Lys Leu Gln Leu Phe Gln Pro Phe Leu Pro Gly Thr Tyr Gln 275 280 285 tgc gtc tcg gga ccc tgc cat cac acc ttc cac ctg atc ccg aat acc 24728 Cys Val Ser Gly Pro Cys His His Thr Phe His Leu Ile Pro Asn Thr 290 295 300 aca gcg ccg ctc ccc gct act aac aac caa act acc cac caa cgc cac 24776 Thr Ala Pro Leu Pro Ala Thr Asn Asn Gln Thr Thr His Gln Arg His 305 310 315 cgt cgc gac ctt tcc tct gaa tct aat acc act acc gga ggt gag ctc 24824 Arg Arg Asp Leu Ser Ser Glu Ser Asn Thr Thr Thr Gly Gly Glu Leu 320 325 330 335 cga ggt cga cca acc tct ggg att tac tac ggc ccc tgg gag gtg gtg 24872 Arg Gly Arg Pro Thr Ser Gly Ile Tyr Tyr Gly Pro Trp Glu Val Val 340 345 350 ggg tta ata gcg cta ggc cta gtt gtg ggt ggg ctt ttg gct ctc tgc 24920 Gly Leu Ile Ala Leu Gly Leu Val Val Gly Gly Leu Leu Ala Leu Cys 355 360 365 tac cta tac ctc cct tgc tgt tcg tac tta gtg gtg ctg tgt tgc tgg 24968 Tyr Leu Tyr Leu Pro Cys Cys Ser Tyr Leu Val Val Leu Cys Cys Trp 370 375 380 ttt aag aaa tgg ggc aga tca ccc tagtgagctg cggtgtgctg gtggcggtgc 25022 Phe Lys Lys Trp Gly Arg Ser Pro 385 390 tttcgattgt gggactgggc ggcgcggctg tagtgaagga ggagaaggcc gatccctgct 25082 tgcatttcaa tcccgacaaa tgccagctga gttttcagcc cgatggcaat cggtgcgcgg 25142 tgctgatcaa gtgcggatgg gaatgcgaga acgtgagaat cgagtacaat aacaagactc 25202 ggaacaatac tctcgcgtcc gtgtggcagc ccggggaccc cgagtggtac accgtctctg 25262 tccccggtgc tgacggctcc ccgcgcaccg tgaacaatac tttcattttt gcgcacatgt 25322 gcgacacggt catgtggatg agcaagcagt acgatatgtg gccccccacg aaggagaaca 25382 tcgtggtctt ctccatcgct tacagcctgt gcacggtgct aatcaccgct atcgtgtgcc 25442 tgagcattca catgctcatc gctattcgcc ccagaaataa tgccgaaaaa gaaaaacagc 25502 cataacacgt tttttcacac acctttttca gaccatggcc tctgttaaat ttttgctttt 25562 atttgccagt ctcattactg ttataagtaa tgagaaactc actatttaca ttggcactaa 25622 ccacactcta gaaggaattc caaaatcctc atggtattgc tattttgatc aagatccaga 25682 cttaactata gaactgtgtg gtaacaatgg acaaaataca agcattcatt taattaactt 25742 taaatgcgga gacgatttga aattaattaa tatcactaaa gagtatggag gtatgtatta 25802 ctatgttgca gaaaataaca acatgcagtt ttatgaagtt actgtaacta atcccaccac 25862 acctagaaca acaacaacca ccacaaaaac tacacctgtt accactatgc agctcgctac 25922 caataacatt tttgccatgc gtcaaatggt caacaatagc actcaaccca ccccacccag 25982 tgaggaaatt cccaaatcca tgattggcat tattgttgct gtagtggtgt gcatgttgat 26042 catcgccttg tgcatggtgt actatgcctt ctgctacaga aagcacagac tgaacgacaa 26102 gctggaacac ttactaagtg ttgaatttta attttttaga accatgaaga tcctaggcct 26162 tttagttttt tctatcatta cctctgctct ttgtgaatca gtggataaag atgttactat 26222 taccactggt tctaactata cactgaaagg gccaccctca ggtatgcttt cgtggtattg 26282 ctattttgga aatgacgcag agcaaactga gctttgcaat gcaatgaaag gccaaatgcc 26342 aaccacaaaa attaaacata aatgtgatgg tagtgatcta atactactca atgtcacgaa 26402 agcatatggt ggcagttatt catgccctgc tgccaacact gaggatatga ttttttacaa 26462 agtggaagtg gttgatccca ctactccacc acccaccacc acaactactc acaccacaca 26522 cacagaacaa accacagcag aggaggcagc aaagttagcc ttgcaggtcc aagacagttc 26582 atttgttggc attaccccta cacccgatca gcggtgtccg gggctgctcg tcagcggcat 26642 tgtcggtgtg ctttcgggat tagcagtcat aatcatctgc atgttcattt ttgcttgctg 26702 ctatagaagg ctttaccgac aaaaatcaga cccactgctg aacctctatg tttaattttt 26762 tccagagcca tgaaggcagt tagcactcta attttttgtt ctttgattgg cactgttttt 26822 agtgttagct ttttgaaaca aattaatgtt actgaggggg aaaatgtgac actggtaggc 26882 gtagaaggtg ctcaaaatac cacctggaca aaataccacc tcgatgggtg gaaagatatt 26942 tgcaattgga gtgtcattac ttacacatgt gagggagtta atttgaccat agtcaatgcc 27002 agccaaaatc agaagggttg gattaaaggg caatctgtta gtgttaccag ccaggggtac 27062 tatacccagc atactcttat ttatgacatt gtagttatac cgctgccaac gcctagccca 27122 cctagcacca ctacacaaac aacccacact acacagacaa ccacatacag tacatcaaat 27182 caacctacca ccactacagc agcagaggtt gccagctcgt ctggggtccg agtggcattt 27242 ttgttattgg ccccatctag cagtcccact gctagtacca atgagcagac tactgatttt 27302 ttgtccactg tcgagagcca caccacagct acctcgagtg ccttctctag caccgccaat 27362 ctctcctcgc tttcctctac accaatcagt cccgctacta ctcctagccc cgctcctctt 27422 cccactcccc tgaagcaaac agacggcggc atgcaatggc agatcaccct gctcattgtg 27482 atcgggttgg tcatcctggc cgtgttgctc tactacatct tctgccgccg cattcccaac 27542 gcgcaccgca agccggccta caagcccatc gttatcgggc agccggagcc gcttcaggtg 27602 gaagggggtc taaggaatct tctcttctct tttacagtat ggtgattgaa ctatgattcc 27662 tagacaattc ttgatcacta ttcttatctg cctcctccaa gtctgtgcca ccctcgctct 27722 ggtggccaac gccagtccag actgtattgg gcccttcgcc tcctacgtgc tctttgcctt 27782 cgtcacctgc atctgctgct gtagcatagt ctgcctgctt atcaccttct tccagttcat 27842 tgactggatc tttgtgcgca tcgcctacct gcgccaccac ccccagtacc gcgaccagcg 27902 agtggcgcgg ctgctcaggc tcctctgata agcatgcggg ctctgctact tctcgcgctt 27962 ctgctgttag tgctcccccg tcccgtcgac ccccggtccc ccactcagtc ccccgaggag 28022 gtccgcaaat gcaaattcca agaaccctgg aaattcctca aatgctaccg ccaaaaatca 28082 gacatgcatc ccagctggat catgatcatt gggatcgtga acattctggc ctgcaccctc 28142 atctcctttg tgatttaccc ctactttgac tttggttgga actcgccaga ggcgctctat 28202 ctcccgcctg aacctgacac accaccacag caacctcagg cacacgcact accaccacca 28262 cagcctaggc cacaatacat gcccatatta gactatgagg ccgagccaca gcgacccatg 28322 ctccccgcta ttagttactt caatctaacc ggcggag atg act gac cca ctg gcc 28377 Met Thr Asp Pro Leu Ala 395 aac aac aac gtc aac gac ctt ctc ctg gac atg gac ggc cgc gcc tcg 28425 Asn Asn Asn Val Asn Asp Leu Leu Leu Asp Met Asp Gly Arg Ala Ser 400 405 410 gag cag cga ctc gcc caa ctt cgc att cgc cag cag cag gag aga gcc 28473 Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg Gln Gln Gln Glu Arg Ala 415 420 425 gtc aag gag ctg cag gac ggc ata gcc atc cac cag tgc aag aaa ggc 28521 Val Lys Glu Leu Gln Asp Gly Ile Ala Ile His Gln Cys Lys Lys Gly 430 435 440 445 atc ttc tgc ctg gtg aaa cag gcc aag atc tcc tac gag gtc acc cag 28569 Ile Phe Cys Leu Val Lys Gln Ala Lys Ile Ser Tyr Glu Val Thr Gln 450 455 460 acc gac cat cgc ctc tcc tac gag ctc ctg cag cag cgc cag aag ttc 28617 Thr Asp His Arg Leu Ser Tyr Glu Leu Leu Gln Gln Arg Gln Lys Phe 465 470 475 acc tgc ctg gtc gga gtc aac ccc atc gtc atc acc cag cag tcg gga 28665 Thr Cys Leu Val Gly Val Asn Pro Ile Val Ile Thr Gln Gln Ser Gly 480 485 490 gat acc aag ggg tgc atc cac tgc tcc tgc gac tcc ccc gac tgc gtc 28713 Asp Thr Lys Gly Cys Ile His Cys Ser Cys Asp Ser Pro Asp Cys Val 495 500 505 cac act ctg atc aag acc ctc tgc ggc ctc cgc gac ctc ctc ccc atg 28761 His Thr Leu Ile Lys Thr Leu Cys Gly Leu Arg Asp Leu Leu Pro Met 510 515 520 525 aac taatcacccc cttatccagt gaaataaaga tcatat 28800 Asn <210> 124 <211> 184 <212> PRT <213> Artificial Sequence <220> <221> misc_feature <222> (84)..(84) <223> The 'Xaa' at location 84 stands for Arg, or Gln. <220> <223> Synthetic Construct <400> 124 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Pro Glu 1 5 10 15 Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Met Glu Asp 20 25 30 Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser Leu Glu 35 40 45 Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala Ala Ala Ala Arg Pro 50 55 60 Ser Ser Ser Ala Glu Glu Glu Lys Ala Ser Ser Thr Asp Thr Ile Ser 65 70 75 80 Ala Pro Gly Xaa Gly Arg Gly Gly Arg Ala His Ser Arg Trp Asp Glu 85 90 95 Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys Glu Arg 100 105 110 Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser Cys 115 120 125 Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu Leu 130 135 140 Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr Arg 145 150 155 160 His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu Ala Glu Thr Gln 165 170 175 Gln Gln Gln Lys Thr Ser Gly Ser 180 <210> 125 <211> 207 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 125 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Asp Cys Gly Val Pro Ala Ile Asn Gln 20 25 30 Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys 35 40 45 Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala 50 55 60 Val Val Asn His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala 65 70 75 80 Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro 85 90 95 Phe Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro Cys His His Thr 100 105 110 Phe His Leu Ile Pro Asn Thr Thr Ala Pro Leu Pro Ala Thr Asn Asn 115 120 125 Gln Thr Thr His Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser Asn 130 135 140 Thr Thr Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile Tyr 145 150 155 160 Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val Val 165 170 175 Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser Tyr 180 185 190 Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 195 200 205 <210> 126 <211> 135 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 126 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu Leu Leu Asp 1 5 10 15 Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg 20 25 30 Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Gly Ile Ala Ile 35 40 45 His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile 50 55 60 Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser Tyr Glu Leu Leu 65 70 75 80 Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val 85 90 95 Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys 100 105 110 Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu 115 120 125 Arg Asp Leu Leu Pro Met Asn 130 135 <210> 127 <211> 38697 <212> DNA <213> Artificial Sequence <220> <223> Simian adenovirus A1320 clone <220> <221> rep_origin <222> (1025)..(1025) <223> ORI <220> <221> misc_feature <222> (1783)..(2646) <223> AP(R) complement (1783..2646) <220> <221> repeat_region <222> (2871)..(2993) <223> ITR <220> <221> misc_feature <222> (3348)..(3373) <223> I-Ceu\recognition site <220> <221> enhancer <222> (3715)..(3975) <223> Enhancer <220> <221> TATA_signal <222> (4177)..(4180) <223> TATA <220> <221> CDS <222> (4299)..(5390) <223> Gag\short <220> <221> polyA_signal <222> (5543)..(5745) <223> BGH-PolyA <220> <221> misc_feature <222> (5818)..(5856) <223> PI-Scel recognition site <220> <221> misc_feature <222> (6858)..(8479) <223> IVa2 complement (6858..8188,8468..8479) <220> <221> misc_feature <222> (8468)..(16733) <223> pol complement (8468..11530,16725..16733) <220> <221> misc_feature <222> (9358)..(9358) <223> is c or g <220> <221> misc_feature <222> (11338)..(16733) <223> pTP complement (11338..13275,16725..16733) <220> <221> CDS <222> (13731)..(14903) <223> 52K <220> <221> CDS <222> (14930)..(16690) <223> pIIIa <220> <221> CDS <222> (16773)..(18398) <223> penton <220> <221> CDS <222> (18405)..(18986) <223> pVII <220> <221> CDS <222> (19034)..(20077) <223> V <220> <221> CDS <222> (20105)..(20335) <223> pX <220> <221> CDS <222> (20408)..(21139) <223> pVI <220> <221> CDS <222> (21246)..(24074) <223> hexon <220> <221> CDS <222> (24096)..(24719) <223> protease <220> <221> misc_feature <222> (24804)..(36339) <223> DBP complement (24804..26339) <220> <221> CDS <222> (26368)..(28761) <223> 100K <220> <221> CDS <222> (29387)..(30067) <223> pVIII <220> <221> CDS <222> (30071)..(30388) <223> E3\12.5K <220> <221> CDS <222> (30950)..(31477) <223> E3\gp19K <220> <221> CDS <222> (31510)..(32109) <223> E3\CR1-beta <220> <221> CDS <222> (32126)..(32737) <223> E3\CR1-gamma <220> <221> CDS <222> (32755)..(33630) <223> E3\CR1-delta <220> <221> CDS <222> (33922)..(34350) <223> E3\RID-beta <220> <221> CDS <222> (35047)..(36381) <223> fiber <220> <221> misc_feature <222> (36474)..(37807) <223> E4\orf\6/7 complement (36474..36724,37457..37807) <220> <221> misc_feature <222> (36725)..(37627) <223> E4\orf6 complement (36725..37627) <220> <221> misc_feature <222> (37536)..(37898) <223> E4\orf4 complement (37536..37898) <220> <221> misc_feature <222> (37788)..(37807) <223> end of E4\orf6/7 <400> 127 ctagcctggc gaacaggtgg gtaaatcgtt ctctccagca ccaggcaggc cacggggtct 60 ccggcgcgac cctcgtaaaa attgtcgcta tgattgaaaa ccatcacaga gagacgttcc 120 cggtggccgg cgtgaatgat tcgacaagat gaatacaccc ccggaacatt ggcgtccgcg 180 agtgaaaaaa agcggccgag gaagcaataa ggcactacaa tgctcagtct caagtccagc 240 aaagcgatgc catgcggatg aagcacaaaa ttctcaggtg cgtacaaaat gtaattactc 300 ccctcctgca caggcagcaa agccccagat ccctccagat acacatacaa agcctcagcg 360 tccatagctt accgagcagc agcacacaac aggcgcaaga gtcagagaaa ggctgagctc 420 taacctgtcc cccgctctct gctcaatata tagcccagat ctacactgac gtaaaggcca 480 aagtctaaaa atacccgcca aataatcaca cacgcccagc acacgcccag aaaccggtga 540 cacactcaaa aaaatacgcg cacttcctca aacgcccaaa ctgccgtcat ttccgggttc 600 ccacgctacg tcatcagaat tcgactttca aatccgtcga ccgttaaaca cgtcactcgc 660 cccgccccta acggtcgccc tcctctcggc caatcacagc cccgcatccc caaattcaaa 720 cgcctcattt gcatattaac gcgcacaaaa agtttgaggt atattattga tgatgatcgt 780 ttaaactatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg 840 ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt 900 atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa 960 gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc 1020 gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag 1080 gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt 1140 gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg 1200 aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg 1260 ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg 1320 taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac 1380 tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg 1440 gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt 1500 taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg 1560 tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc 1620 tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt 1680 ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt 1740 taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag 1800 tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt 1860 cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg caatgatacc 1920 gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc 1980 cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg 2040 ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctgc 2100 aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg 2160 atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc 2220 tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact 2280 gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc 2340 aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaac 2400 acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc 2460 ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac 2520 tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa 2580 aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact 2640 catactcttc ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg 2700 atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg 2760 aaaagtgcca cctgacgtct aagaaaccat tattatcatg acattaacct ataaaaatag 2820 gcgtatcacg aggccctttc gtcttcaaga attgtttaaa ctaccatcat caataatata 2880 cctcaaactt tttgtgcgcg ttaatatgca aatgaggcgt ttgaatttgg ggatgcgggg 2940 cggtgattgg ctgtgggaaa ggcgaccgtt aggggcgggg cgggtgacgt tttgatgacg 3000 tgtttgtgag gcggagccgg tttgcaagtt ctcgtgggaa aagtgacgtc aaacgaggtg 3060 tggtttgaac acggaaatac tcaattttcc cgcgctctct gacaggaaat gaggtgtttc 3120 tgggcggatg caagtgaaaa cgggccattt tcgcgcgaaa actgaatgag gaagtgaaaa 3180 tctgagtaat ttcgcgttta tggcagggag gagtatttgc cgagggccga gtagactttg 3240 accgattacg tgggggtttc gattaccgtg tttttcacct aaatttccgc gtacggtgtc 3300 aaagtccggt gtttttacat catttccccg aaaagtgcca cctgacgtaa ctataacggt 3360 cctaaggtag cgaaagctca gatctggatc tcccgatccc ctatggcgac tctcagtaca 3420 atctgctctg atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc 3480 gctgagtagt gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc 3540 atgaagaatc tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat 3600 acgcgttgac attgattatt gactagttat taatagtaat caattacggg gtcattagtt 3660 catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga 3720 ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca 3780 atagggactt tccattgacg tcaatgggtg gactatttac ggtaaactgc ccacttggca 3840 gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg 3900 cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc 3960 tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt 4020 ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt 4080 ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg 4140 acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc tcgtttagtg 4200 aaccgtcaga tcgcctggag acgccatcca cgctgttttg acctccatag aagacaccgg 4260 gaccgatcca gcctccgcgg gcgcgcgtcg acagagag atg ggt gcg aga gcg tca 4316 Met Gly Ala Arg Ala Ser 1 5 gta tta agc ggg gga gaa tta gat cga tgg gaa aaa att cgg tta agg 4364 Val Leu Ser Gly Gly Glu Leu Asp Arg Trp Glu Lys Ile Arg Leu Arg 10 15 20 cca ggg gga aag aag aag tac aag cta aag cac atc gta tgg gca agc 4412 Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys His Ile Val Trp Ala Ser 25 30 35 agg gag cta gaa cga ttc gca gtt aat cct ggc ctg tta gaa aca tca 4460 Arg Glu Leu Glu Arg Phe Ala Val Asn Pro Gly Leu Leu Glu Thr Ser 40 45 50 gaa ggc tgt aga caa ata ctg gga cag cta caa cca tcc ctt cag aca 4508 Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu Gln Pro Ser Leu Gln Thr 55 60 65 70 gga tca gag gag ctt cga tca cta tac aac aca gta gca acc ctc tat 4556 Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn Thr Val Ala Thr Leu Tyr 75 80 85 tgt gtg cac cag cgg atc gag atc aag gac acc aag gaa gct tta gac 4604 Cys Val His Gln Arg Ile Glu Ile Lys Asp Thr Lys Glu Ala Leu Asp 90 95 100 aag ata gag gaa gag caa aac aag tcc aag aag aag gcc cag cag gca 4652 Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys Lys Lys Ala Gln Gln Ala 105 110 115 gca gct gac aca gga cac agc aat cag gtc agc caa aat tac cct ata 4700 Ala Ala Asp Thr Gly His Ser Asn Gln Val Ser Gln Asn Tyr Pro Ile 120 125 130 gtg cag aac atc cag ggg caa atg gta cat cag gcc ata tca cct aga 4748 Val Gln Asn Ile Gln Gly Gln Met Val His Gln Ala Ile Ser Pro Arg 135 140 145 150 act tta aat gca tgg gta aaa gta gta gaa gag aag gct ttc agc cca 4796 Thr Leu Asn Ala Trp Val Lys Val Val Glu Glu Lys Ala Phe Ser Pro 155 160 165 gaa gtg ata ccc atg ttt tca gca tta tca gaa gga gcc acc cca cag 4844 Glu Val Ile Pro Met Phe Ser Ala Leu Ser Glu Gly Ala Thr Pro Gln 170 175 180 gac ctg aac acg atg ttg aac acc gtg ggg gga cat caa gca gcc atg 4892 Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln Ala Ala Met 185 190 195 caa atg tta aaa gag acc atc aat gag gaa gct gca gat tgg gat aga 4940 Gln Met Leu Lys Glu Thr Ile Asn Glu Glu Ala Ala Asp Trp Asp Arg 200 205 210 gtg cat cca gtg cat gca ggg cct att gca cca ggc cag atg aga gaa 4988 Val His Pro Val His Ala Gly Pro Ile Ala Pro Gly Gln Met Arg Glu 215 220 225 230 cca agg gga agt gac ata gca gga act act agt acc ctt cag gaa caa 5036 Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Thr Leu Gln Glu Gln 235 240 245 ata gga tgg atg aca aat aat cca cct atc cca gta gga gag atc tac 5084 Ile Gly Trp Met Thr Asn Asn Pro Pro Ile Pro Val Gly Glu Ile Tyr 250 255 260 aag agg tgg ata atc ctg gga ttg aac aag atc gtg agg atg tat agc 5132 Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg Met Tyr Ser 265 270 275 cct acc agc att ctg gac ata aga caa gga cca aag gaa ccc ttt aga 5180 Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly Pro Lys Glu Pro Phe Arg 280 285 290 gac tat gta gac cgg ttc tat aaa act cta aga gct gag caa gct tca 5228 Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu Arg Ala Glu Gln Ala Ser 295 300 305 310 cag gag gta aaa aat tgg atg aca gaa acc ttg ttg gtc caa aat gcg 5276 Gln Glu Val Lys Asn Trp Met Thr Glu Thr Leu Leu Val Gln Asn Ala 315 320 325 aac cca gat tgt aag acc atc ctg aag gct ctc ggc cca gcg gct aca 5324 Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala Leu Gly Pro Ala Ala Thr 330 335 340 cta gaa gaa atg atg aca gca tgt cag gga gta gga gga ccc ggc cat 5372 Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly Pro Gly His 345 350 355 aag gca aga gtt ttg tag ggatccacta gttctagact cgaggggggg 5420 Lys Ala Arg Val Leu 360 cccggtacct ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa 5480 agaaaagggg ggactggaag ggctaattca ctcccaaaga agacaagata aaccgctgat 5540 cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt 5600 ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat 5660 cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg 5720 gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg 5780 aggcggaaag aaccagcaga tctgcagatc tgaattcatc tatgtcgggt gcggagaaag 5840 aggtaatgaa atggcattat gggtattatg ggtctgcatt aatgaatcgg ccagattatg 5900 ctggccaccg tgcatgtggc ctcgcacccc cgcaagacat ggcccgagtt cgagcacaac 5960 gtcatgaccc gctgcaatgt gcacctgggc tcccgccgag gcatgttcat gccataccag 6020 tgcaacatgc aatttgtgaa ggtgctgctg gagcccgatg ccatgtccag agtgagcctg 6080 acgggggtgt ttgacatgaa tgtggagctg tggaaaattc tgagatatga tgaatccaag 6140 accaggtgcc gggcctgcga atgcggaggc aagcacgcca ggcttcagcc cgtgtgtgtg 6200 gaggtgacgg aggacctgcg acccgatcat ttggtgttgt cctgcaacgg gacggagttc 6260 ggctccagcg gggaagaatc tgactagagt gagtagtgtt tgggggtggg tgggagcctg 6320 catgatgggc agaatgacta aaatctgtgt ttttctgcgc agcagcatga gcggaagcgc 6380 ctcctttgag ggaggggtat tcagccctta tctgacgggg cgtctcccct cctgggctgg 6440 agtgcgtcag aatgtgatgg gatccacggt ggacggccgg cccgtgcagc ccgcgaactc 6500 ttcaaccctg acctacgcga ccctgagctc ctcgtccgtg gacgcagctg ccgccgcagc 6560 tgctgcttcc gccgccagcg ccgtgcgcgg aatggccctg ggtgccggct actacagctc 6620 tctggtggcc aactcgagtt ccgccaataa tcccgccagc ctgaacgagg agaagctgct 6680 gctgctgatg gcccagctcg aggccctgac ccagcgcctg ggcgagctga cccagcaggt 6740 ggctcagctg caggcggaga cgcgggccgc ggttgccacg gtgaaaacca aataaaaaat 6800 gaatcaataa ataaacggaa acggttgttg attttaacac agagtcttga atctttattt 6860 gatttttcgc gcgcggtagg ccctggacca ccggtctcga tcattgagca cccggtggat 6920 cttttccagg acccggtaga ggtgggcttg gatgttgagg tacatgggca tgagcccgtc 6980 ccgggggtgg aggtagctcc actgcagggc ctcgtgctcg ggggtggtgt tgtaaatcac 7040 ccagtcatag caggggcgca gggcgtggtg ctgcacgatg tccttgagga ggagactgat 7100 ggccacgggc agtcccttgg tgtaggtgtt gacgaacctg ttgagctggg agggatgcat 7160 gcggggggag atgagatgca tcttggcctg gatcttgaga ttggcgatgt tcccacccag 7220 atcccgccgg gggttcatgt tgtgcaggac caccagcacg gtgtatccgg tgcacttggg 7280 gaatttgtca tgcaacttgg aagggaaggc gtgaaagaat ttggagacgc ccttgtgacc 7340 gcccaggttt tccatgcact catccatgat gatggcgatg ggcccgtggg cggcggcctg 7400 ggcaaagacg tttcgggggt cggacacatc gtagttgtgg tcctgggtga gctcgtcata 7460 ggccatttta atgaatttgg ggcggagggt gcccgactgg gggacaaagg tgccctcgat 7520 cccgggggcg tagttgccct cgcagatctg catctcccag gccttgagct cggagggggg 7580 gatcatgtcc acctgcgggg cgatgaaaaa aacggtttcc ggggcggggg agatgagctg 7640 ggccgaaagc aggttccgga gcagctggga cttgccgcag ccggtggggc cgtagatgac 7700 cccgatgacc ggctgcaggt ggtagttgag ggagagacag ctgccgtcct cgcggaggag 7760 gggggccacc tcgttcatca tctcgcgcac atgcatgttc tcgcgcacga gttccgccag 7820 gaggcgctcg ccccccagcg agaggagctc ttgcagcgag gcgaagtttt tcagcggctt 7880 gagtccgtcg gccatgggca ttttggagag ggtctgttgc aagagttcca gacggtccca 7940 gagctcggtg atgtgctcta gggcatctcg atccagcaga cctcctcgtt tcgcgggttg 8000 gggcggctgc gggagtaggg caccaggcga tgggcgtcca gcgaggccag ggtccggtcc 8060 ttccagggtc gcagggtccg cgtcagcgtg gtctccgtca cggtgaaggg gtgcgcgccg 8120 ggctgggcgc ttgcgagggt gcgcttcagg ctcatccggc tggtcgagaa ccgctcccgg 8180 tcggtgccct gcgcgtcggc caggtagcaa ttgagcatga gttcgtagtt gagcgcctcg 8240 gccgcgtggc ccttggcgcg gagcttacct ttggaagtgt gtccgcagac gggacagagg 8300 agggacttga gggcgtagag cttgggggcg aggaagacgg actcgggggc gtaggcgtcc 8360 gcgccgcagc tggcgcagac ggtctcgcac tccacgagcc aggtgaggtc ggggcggtcg 8420 gggtcaaaaa cgaggtttcc tccgtgcttt ttgatgcgtt tcttacctct ggtctccatg 8480 agctcgtgtc cccgctgggt gacaaagagg ctgtccgtgt ccccgtagac cgactttatg 8540 ggccggtcct cgagcggggt gccgcggtcc tcgtcgtaga ggaaccccgc ccactccgag 8600 acgaaggccc gggtccaggc cagcacgaag gaggccacgt gggaggggta gcggtcgttg 8660 tccaccagcg ggtccacctt ctccagggta tgcaagcaca tgtccccctc gtccacatcc 8720 aggaaggtga ttggcttgta agtgtaggcc acgtgaccgg gggtcccggc cgggggggta 8780 taaaaggggg cgggcccctg ctcgtcctca ctgtcttccg gatcgctgtc caggagcgcc 8840 agctgttggg gtaggtattc cctctcgaag gcgggcatga cctcggcact caggttgtca 8900 gtttctagaa acgaggagga tttgatattg acggtgccgt tggagacgcc tttcatgagc 8960 ccctcgtcca tctggtcaga aaagacgatc tttttgttgt cgagcttggt ggcgaaggag 9020 ccgtagaggg cattggagag gagcttggcg atggagcgca tggtctggtt cttttccttg 9080 tcggcgcgct ccttggcggc gatgttgagc tgcacgtact cgcgcgccac gcacttccat 9140 tcggggaaga cggtggtgag ctcgtcgggc acgattctga cccgccagcc gcggttgtgc 9200 agggtgatga ggtccacgct ggtggccacc tcgccgcgca ggggctcgtt ggtccagcag 9260 aggcgcccgc ccttgcgcga gcagaagggg ggcagcgggt ccagcatgag ctcgtcgggg 9320 gggtcggcgt ccacggtgaa gatgccgggc aggagctcgg ggtcgaagta gctgatgcag 9380 gtgcccagat cgtccagcgc cgcttgccag tcgcgcacgg ccagcgcgcg ctcgtagggg 9440 ctgaggggcg tgccccaggg catggggtgc gtgagcgcgg aggcgtacat gccgcagatg 9500 tcgtagacgt agaggggctc ctcgaggacg ccgatgtagg tggggtagca gcgccccccg 9560 cggatgctgg cgcgcacgta gtcgtacagc tcgtgcgagg gcgcgaggag ccccgcgccg 9620 aggttggagc gctgcggctt ttcggcgcgg tagacgatct ggcggaagat ggcgtgggag 9680 ttggaggaga tggtgggcct ctggaagatg ttgaagtggg cgtggggcag gccgaccgag 9740 tccctgatga agtgggcgta ggagtcctgc agcttggcga cgagctcggc ggtgacgagg 9800 acgtccaggg cgcagtagtc gagggtctct tggatgatgt cgtacttgag ctggcccttc 9860 tgcttccaca gctcgcggtt gagaaggaac tcttcgcggt ccttccagta ctcttcgagg 9920 gggaacccgt cctgatcggc acggtaagag cccaccatgt agaactggtt gacggccttg 9980 taggcgcagc agcccttctc cacggggagg gcataagctt gcgcggcctt gcgcagggag 10040 gtgtgggtga gggcgaaggt gtcgcgcacc atgaccttga ggaactggtg cttgaagtcg 10100 aggtcgtcgc agccgccctg ctcccagagt tggaagtccg tgcgcttctt gtaggcgggg 10160 ttgggcaaag cgaaagtaac atcgttgaag aggatcttgc ccgcgcgggg catgaagttg 10220 cgagtgatgc ggaaaggctg gggcacctcg gcccggttgt tgatgacctg ggcggcgagg 10280 acgatctcgt cgaagccgtt gatgttgtgc ccgacgatgt agagttccac gaatcgcggg 10340 cggcccttga cgtggggcag cttcttgagc tcgtcgtagg tgagctcggc ggggtcgctg 10400 agtccgtgct gctcaagggc ccagtcggcg acgtgggggt tggcgctgag gaaggaagtc 10460 cagagatcca cggccagggc ggtttgcaag cggtcccggt actgacggaa ctgctggccc 10520 acggccattt tttcgggggt gatgcagtag aaggtgcggg ggtcgccgtg ccagcggtcc 10580 cacttgagct ggagggcgag gtcgtgggcg agctcgacaa gcggcgggtc cccggagagt 10640 ttcatgacca gcatgaaggg gacgagctgc ttgccgaagg accccatcca ggtgtaggtt 10700 tccacatcgt aggtgaggaa gagcctttcg gtgcgaggat gcgagccgat ggggaagaac 10760 tggatctcct gccaccagtt ggaggaatgg ctgttgatgt gatggaagta gaaatgccga 10820 cggcgcgccg agcactcgtg cttgtgttta tacaagcgtc cgcagtgctc gcaacgctgc 10880 acgggatgca cgtgctgcac gagctgtacc tgagttcctt tgacgaggaa tttcagtggg 10940 cagtggagcg ctggcggctg catctggtgc tgtactacgt cctggccatc ggcgtggcca 11000 tcgtctgcct cgatggtggt catgctgacg agcccgcgcg ggaggcaggt ccagacctcg 11060 gctcggacgg gtcggagagc gaggacgagg gcgcgcaggc cggagctgtc cagggtcctg 11120 agacgctgcg gagtcaggtc agtgggcagc ggcggcgcgc ggttgacttg caggagcttt 11180 tccagggcgc gcgggaggtc cagatggtac ttgatctcca cggcgccgtt ggtggcgacg 11240 tccacggctt gcagggtccc gtgcccctgg ggcgccacca ccgtgccccg tttcttcttg 11300 ggcgctggcg gcgttggcgc tggttccatg tcggtcagaa gcggcggcga ggacgcgcgc 11360 cgggcggcag gggcggctcg gggcccggag gcaggggcgg caggggcacg tcggcgccgc 11420 gcgcgggcag gttctggtac tgcgcccgga gaagactggc gtgagcgacg acgcgacggt 11480 tgacgtcctg gatctgacgc ctctgggtga aggccacggg acccgtgagt ttgaacctga 11540 aagagagttc gacagaatca atctcggtat cgttgacggc ggcctgccgc aggatctctt 11600 gcacgtcgcc cgagttgtcc tggtaggcga tctcggtcat gaactgctcg atctcctcct 11660 cctgaaggtc tccgcggccg gcgcgctcga cggtggccgc gaggtcgttg gagatgcggg 11720 ccatgagctg cgagaaggcg ttcatgccgg cctcgttcca gacgcggctg tagaccacgg 11780 ctccgtcggg gtcgcgcgcg cgcatgacca cctgggcaag gttgagctcg acgtggcgcg 11840 tgaagaccgc gtagttgcag aggcgctggt agaggtagtt gagcgtggtg gcgatgtgct 11900 cggtgacgaa gaagtacatg atccagcggc ggagcggcat ctcgctgacg tcgcccaggg 11960 cttccaagcg ctccatggcc tcgtagaagt ccacggcgaa gttgaaaaac tgggagttgc 12020 gcgccgagac ggtcaactcc tcctccagaa gacggatgag ctctgcgatg gtggcgcgca 12080 cctcgcgctc gaaggccccg gggggctcct cttcttccat ctcctcctcc tcttcctcct 12140 ccactaacat ctcttctact tcctcctcag gcggtggtgg cgggggaggg ggcctgcgtc 12200 gccggcggcg cacgggcaga cggtcgatga agcgctcgat ggtctcgccg cgccggcgtc 12260 gcatggtctc ggtgacggcg cgcccgtcct cgcggggccg cagcgtgaag acgccgccgc 12320 gcatctccag gtggccgggg gggtccccgt tgggcaggga gagggcgctg acgatgcatc 12380 ttatcaattg ccccgtaggg actccgcgca aggacctgag cgtctcgaga tccacgggat 12440 ctgaaaaccg ttgaacgaag gcttcgagcc agtcgcagtc gcaaggtagg ctgagcacgg 12500 tttcttctgg cgggtcatgt tggttggagg gagcggggcg ggcgatgctg ctggtgatga 12560 agttgaaata ggcggttctg agacggcgga tggtggcgag gagcaccagg tctttgggcc 12620 cggcttgctg gatgcgcaga cggtcggcca tgccccaggc gtggtcctga cacctggcca 12680 ggtccttgta gtagtcctgc atgagccgct ccacgggcac ctcctcctcg cccgcgcggc 12740 cgtgcatgcg cgtgagcccg aagccgcgct ggggctggac gagcgccagg tcggcgacga 12800 cgcgctcggc gaggatggcc tgctggacct gggtgagggt ggtctggaag tcgtcgaagt 12860 cgacgaagcg gtggtaggct ccggtgttga tggtgtagga gcagttggcc atgacggacc 12920 agttgacggt ctggtggccg gggcgcacga gctcgtggta cttgaggcgc gagtaggcgc 12980 gcgtgtcgaa gatgtagtcg ttgcaggtgc gcacgaggta ctggtatccg acgaggaagt 13040 gcggcggcgg ctggcggtag agcggccatc gctcggtggc gggggcgccg ggcgcgaggt 13100 cctcgagcat gaggcggtgg tagccgtaga tgtacctgga catccaggtg atgccggcgg 13160 cggtggtgga ggcgcgcggg aactcgcgga cgcggttcca gatgttgcgc agcggcagga 13220 agtagttcat ggtggccgcg gtctggcccg tgaggcgcgc gcagtcgtgg atgctctaga 13280 catacgggca aaaacgaaag cggtcagcgg ctcgactccg tggcctggag gctaagcgaa 13340 cgggttgggc tgcgcgtgta ccccggttcg agtctctgct cgaatcaggc tggagccgca 13400 gctaacgtgg tactggcact cccgtctcga cccaagcctg ctaacgaaac ctccaggata 13460 cggaggcggg tcgttttttg gccttggtca ctggtcatga aaaactagta agcgcggaaa 13520 gcggccgccc gcgatggctc gctgccgtag tctggagaaa gaatcgccag ggttgcgttg 13580 cggtgtgccc cggttcgaga ctcagcgctc ggcgccggcc ggattccgcg gctaacgtgg 13640 gcgtggctgc cccgtcgttt ccaagacccc ttagccagcc gacttctcca gttacggagc 13700 gagcccctct ttttcttgtg tttttgccag atg cat ccc gta ctg cgg cag atg 13754 Met His Pro Val Leu Arg Gln Met 365 370 cgc ccc cac cct cca cca caa ccg ccc cta ccg ccg cag cag cag caa 13802 Arg Pro His Pro Pro Pro Gln Pro Pro Leu Pro Pro Gln Gln Gln Gln 375 380 385 cag ccg gcg ctt ctg ccc ccg ccc cag cag cag cca gcc act acc gcg 13850 Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln Pro Ala Thr Thr Ala 390 395 400 gcg gcc gcc gtg agc gga gcc ggc gtt cag tat gac ctg gcc ttg gaa 13898 Ala Ala Ala Val Ser Gly Ala Gly Val Gln Tyr Asp Leu Ala Leu Glu 405 410 415 gag ggc gag ggg ctg gcg cgg ctg ggg gcg tcg tcg ccg gag cgg cac 13946 Glu Gly Glu Gly Leu Ala Arg Leu Gly Ala Ser Ser Pro Glu Arg His 420 425 430 435 ccg cgc gtg cag atg aaa agg gac gct cgc gag gcc tac gtg ccc aag 13994 Pro Arg Val Gln Met Lys Arg Asp Ala Arg Glu Ala Tyr Val Pro Lys 440 445 450 cag aac ctg ttc aga gac agg agc ggc gag gag ccc gag gag atg cgc 14042 Gln Asn Leu Phe Arg Asp Arg Ser Gly Glu Glu Pro Glu Glu Met Arg 455 460 465 gcc tcc cgc ttc cac gcg ggg cgg gag ctg cgg cgc ggc ctg gac cga 14090 Ala Ser Arg Phe His Ala Gly Arg Glu Leu Arg Arg Gly Leu Asp Arg 470 475 480 aag cgg gtg ctg agg gac gag gat ttc gag gcg gac gag ctg acg ggg 14138 Lys Arg Val Leu Arg Asp Glu Asp Phe Glu Ala Asp Glu Leu Thr Gly 485 490 495 atc agc ccc gcg cgc gcg cac gtg gcc gcg gcc aac ctg gtc acg gcg 14186 Ile Ser Pro Ala Arg Ala His Val Ala Ala Ala Asn Leu Val Thr Ala 500 505 510 515 tac gag cag acc gtg aag gag gag agc aac ttc caa aaa tcc ttc aac 14234 Tyr Glu Gln Thr Val Lys Glu Glu Ser Asn Phe Gln Lys Ser Phe Asn 520 525 530 aac cac gtg cgc acg ctg atc gcg cgc gag gag gtg acc ctg ggc ctg 14282 Asn His Val Arg Thr Leu Ile Ala Arg Glu Glu Val Thr Leu Gly Leu 535 540 545 atg cat ctg tgg gac ctg ttg gag gcc atc gtg cag aac ccc acg agc 14330 Met His Leu Trp Asp Leu Leu Glu Ala Ile Val Gln Asn Pro Thr Ser 550 555 560 aag ccg ctg acg gcg cag ctg ttt ctg gtg gtg cag cac agt cgg gac 14378 Lys Pro Leu Thr Ala Gln Leu Phe Leu Val Val Gln His Ser Arg Asp 565 570 575 aac gag acg ttc agg gag gcg ctg ctg aat atc acc gag ccc gag ggc 14426 Asn Glu Thr Phe Arg Glu Ala Leu Leu Asn Ile Thr Glu Pro Glu Gly 580 585 590 595 cgc tgg ctc ctg gac ctg gtg aac att ctg cag agc atc gtg gtg cag 14474 Arg Trp Leu Leu Asp Leu Val Asn Ile Leu Gln Ser Ile Val Val Gln 600 605 610 gag cgc ggg ctg ccg ctg tcc gag aag ctg gcg gcc atc aac ttc tcg 14522 Glu Arg Gly Leu Pro Leu Ser Glu Lys Leu Ala Ala Ile Asn Phe Ser 615 620 625 gtg ctg agc ctg ggc aag tac tac gct agg aag atc tac aag acc ccg 14570 Val Leu Ser Leu Gly Lys Tyr Tyr Ala Arg Lys Ile Tyr Lys Thr Pro 630 635 640 tac gtg ccc ata gac aag gag gtg aag atc gac ggg ttt tac atg cgc 14618 Tyr Val Pro Ile Asp Lys Glu Val Lys Ile Asp Gly Phe Tyr Met Arg 645 650 655 atg acc ctg aaa gtg ctg acc ctg agc gac gat ctg ggg gtg tac cgc 14666 Met Thr Leu Lys Val Leu Thr Leu Ser Asp Asp Leu Gly Val Tyr Arg 660 665 670 675 aac gac agg atg cac cgc gcg gtg agc gcc agc cgc cgg cgc gag ctg 14714 Asn Asp Arg Met His Arg Ala Val Ser Ala Ser Arg Arg Arg Glu Leu 680 685 690 agc gac cag gag ctg atg cac agc ctg cag cgg gcc ctg acc ggg gcc 14762 Ser Asp Gln Glu Leu Met His Ser Leu Gln Arg Ala Leu Thr Gly Ala 695 700 705 ggg acc gag ggg gag agc tac ttt gac atg ggc gcg gac ctg cgc tgg 14810 Gly Thr Glu Gly Glu Ser Tyr Phe Asp Met Gly Ala Asp Leu Arg Trp 710 715 720 cag ccc agc cgc cgg gct tta gag gca gcc ggc ggc gtg ccc tac gtg 14858 Gln Pro Ser Arg Arg Ala Leu Glu Ala Ala Gly Gly Val Pro Tyr Val 725 730 735 gag gag gtg gac gat gat gag gag gag ggc gag tac ctg gaa gac 14903 Glu Glu Val Asp Asp Asp Glu Glu Glu Gly Glu Tyr Leu Glu Asp 740 745 750 tgatggcgcg accgtatttt tgctag atg cag caa cag cca ccg cct cct gat 14956 Met Gln Gln Gln Pro Pro Pro Pro Asp 755 760 ccc gcg atg cgg gcg gcg ctg cag agc cag ccg tcc ggc att aac tcc 15004 Pro Ala Met Arg Ala Ala Leu Gln Ser Gln Pro Ser Gly Ile Asn Ser 765 770 775 tcg gac gat tgg acc cag gcc atg caa cgc atc atg gcg ctg acg acc 15052 Ser Asp Asp Trp Thr Gln Ala Met Gln Arg Ile Met Ala Leu Thr Thr 780 785 790 795 cgc aat ccc gaa gcc ttt aga cag cag cct cag gcc aac cgg ctc tcg 15100 Arg Asn Pro Glu Ala Phe Arg Gln Gln Pro Gln Ala Asn Arg Leu Ser 800 805 810 gcc atc ctg gag gcc gtg gtg ccc tcg cgc tcg aac ccc acg cac gag 15148 Ala Ile Leu Glu Ala Val Val Pro Ser Arg Ser Asn Pro Thr His Glu 815 820 825 aag gtg ctg gcc atc gtg aac gcg ctg gtg gag aac aag gcc atc cgc 15196 Lys Val Leu Ala Ile Val Asn Ala Leu Val Glu Asn Lys Ala Ile Arg 830 835 840 ggc gac gag gcc ggg ctg gtg tac aac gcg ctg ctg gag cgc gtg gcc 15244 Gly Asp Glu Ala Gly Leu Val Tyr Asn Ala Leu Leu Glu Arg Val Ala 845 850 855 cgc tac aac agc acc aac gtg cag acg aac ctg gac cgc atg gtg acc 15292 Arg Tyr Asn Ser Thr Asn Val Gln Thr Asn Leu Asp Arg Met Val Thr 860 865 870 875 gac gtg cgc gag gcg gtg tcg cag cgc gag cgg ttc cac cgc gag tcg 15340 Asp Val Arg Glu Ala Val Ser Gln Arg Glu Arg Phe His Arg Glu Ser 880 885 890 aac ctg ggc tcc atg gtg gcg ctg aac gcc ttc ctg agc acg cag ccc 15388 Asn Leu Gly Ser Met Val Ala Leu Asn Ala Phe Leu Ser Thr Gln Pro 895 900 905 gcc aac gtg ccc cgg ggc cag gag gac tac acc aac ttt atc agc gcg 15436 Ala Asn Val Pro Arg Gly Gln Glu Asp Tyr Thr Asn Phe Ile Ser Ala 910 915 920 ctg cgg ctg atg gtg gcc gag gtg ccc cag agc gag gtg tac cag tcg 15484 Leu Arg Leu Met Val Ala Glu Val Pro Gln Ser Glu Val Tyr Gln Ser 925 930 935 ggg ccg gac tac ttc ttc cag acc agt cgc cag ggc ttg cag acc gtg 15532 Gly Pro Asp Tyr Phe Phe Gln Thr Ser Arg Gln Gly Leu Gln Thr Val 940 945 950 955 aac ctg agc cag gct ttc aag aac ttg cag gga ctg tgg ggc gtg cag 15580 Asn Leu Ser Gln Ala Phe Lys Asn Leu Gln Gly Leu Trp Gly Val Gln 960 965 970 gcc ccg gtc ggg gac cgc gcg acg gtg tcg agc ctg ctg acg ccg aac 15628 Ala Pro Val Gly Asp Arg Ala Thr Val Ser Ser Leu Leu Thr Pro Asn 975 980 985 tcg cgc ctg ctg ctg ctg ctg gtg gcg ccc ttc acg gac agc ggc agc 15676 Ser Arg Leu Leu Leu Leu Leu Val Ala Pro Phe Thr Asp Ser Gly Ser 990 995 1000 gtg agc cgc gac tcg tac ctg ggc tac ctg ctt aac ctg tac cgc 15721 Val Ser Arg Asp Ser Tyr Leu Gly Tyr Leu Leu Asn Leu Tyr Arg 1005 1010 1015 gag gcc atc ggg cag gcg cac gtg gac gag cag acc tac cag gag 15766 Glu Ala Ile Gly Gln Ala His Val Asp Glu Gln Thr Tyr Gln Glu 1020 1025 1030 atc acc cac gtg agc cgc gcg ctg ggc cag gag gac ccg ggc aac 15811 Ile Thr His Val Ser Arg Ala Leu Gly Gln Glu Asp Pro Gly Asn 1035 1040 1045 ctg gag gcc acc ctg aac ttc ctg ctg acc aac cgg tcg cag aag 15856 Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr Asn Arg Ser Gln Lys 1050 1055 1060 atc ccg ccc cag tac gcg ctg agc acc gag gag gag cgc atc ctg 15901 Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu Glu Arg Ile Leu 1065 1070 1075 cgc tac gtg cag cag agc gtg ggg ctg ttc ctg atg cag gag ggg 15946 Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met Gln Glu Gly 1080 1085 1090 gcc acg ccc agc gcc gcg ctc gac atg acc gcg cgc aac atg gag 15991 Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn Met Glu 1095 1100 1105 ccc agc atg tac gcc cgc aac cgc ccg ttc atc aat aag ctg atg 16036 Pro Ser Met Tyr Ala Arg Asn Arg Pro Phe Ile Asn Lys Leu Met 1110 1115 1120 gac tac ttg cat cgg gcg gcc gcc atg aac tcg gac tac ttt acc 16081 Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr 1125 1130 1135 aac gcc atc ttg aac ccg cac tgg ctc ccg ccg ccc ggg ttc tac 16126 Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr 1140 1145 1150 acg ggc gag tac gac atg ccc gac ccc aac gac ggg ttc ctg tgg 16171 Thr Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp 1155 1160 1165 gac gac gtg gac agc agc gtg ttc tcg ccg cgc ccc acc acc acc 16216 Asp Asp Val Asp Ser Ser Val Phe Ser Pro Arg Pro Thr Thr Thr 1170 1175 1180 gtg tgg aag aaa gag ggc ggg gac cgg cgg ccg tcc tcg gcg ctg 16261 Val Trp Lys Lys Glu Gly Gly Asp Arg Arg Pro Ser Ser Ala Leu 1185 1190 1195 tcc ggt cgc gcg ggt gct gcc gcg gcg gtg ccc gag gcc gcc agc 16306 Ser Gly Arg Ala Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser 1200 1205 1210 ccc ttc ccg agc ctg ccc ttt tcg ctg aac agc gtg cgc agc agc 16351 Pro Phe Pro Ser Leu Pro Phe Ser Leu Asn Ser Val Arg Ser Ser 1215 1220 1225 gag ctg ggt cgg ctg acg cgg ccg cgc ctg ctg ggc gag gag gag 16396 Glu Leu Gly Arg Leu Thr Arg Pro Arg Leu Leu Gly Glu Glu Glu 1230 1235 1240 tac ctg aac gac tcc ttg ttg agg ccc gag cgc gag aaa aac ttc 16441 Tyr Leu Asn Asp Ser Leu Leu Arg Pro Glu Arg Glu Lys Asn Phe 1245 1250 1255 ccc aat aac ggg ata gag agc ctg gtg gac aag atg agc cgc tgg 16486 Pro Asn Asn Gly Ile Glu Ser Leu Val Asp Lys Met Ser Arg Trp 1260 1265 1270 aag acg tac gcg cac gag cac agg gac gag ccc cga gct agc agc 16531 Lys Thr Tyr Ala His Glu His Arg Asp Glu Pro Arg Ala Ser Ser 1275 1280 1285 agc gcc ggc gcc acc cgt aga cgc cag cgg cac gac agg cag cgg 16576 Ser Ala Gly Ala Thr Arg Arg Arg Gln Arg His Asp Arg Gln Arg 1290 1295 1300 gga ctg gtg tgg gac gat gag gat tcc gcc gac gac agc agc gtg 16621 Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp Asp Ser Ser Val 1305 1310 1315 ttg gac ttg ggt ggg agt ggt ggt ggt aac ccg ttc gct cac ttg 16666 Leu Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe Ala His Leu 1320 1325 1330 cgc ccc cgt atc ggg cgc ctg atg taagaatctg aaaaaataaa 16710 Arg Pro Arg Ile Gly Arg Leu Met 1335 1340 aaaacggtac tcaccaaggc catggcgacc agcgtgcgtt cttctctgtt gtttgtagta 16770 gt atg atg agg cgc gtg tac ccg gag ggt cct cct ccc tcg tac gag 16817 Met Met Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu 1345 1350 1355 agc gtg atg cag cag gcg gtg gcg gcg gcg atg cag ccc ccg ctg 16862 Ser Val Met Gln Gln Ala Val Ala Ala Ala Met Gln Pro Pro Leu 1360 1365 1370 gag gcg cct tac gtg ccc ccg cgg tac ctg gcg cct acg gag ggg 16907 Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly 1375 1380 1385 cgg aac agc att cgt tac tcg gag ctg gca ccc ttg tac gat acc 16952 Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr 1390 1395 1400 acc cgg ttg tac ctg gtg gac aac aag tcg gcg gac atc gcc tcg 16997 Thr Arg Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser 1405 1410 1415 ctg aac tac cag aac gac cac agc aac ttc ctg acc acc gtg gtg 17042 Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val 1420 1425 1430 cag aac aac gat ttc acc ccc acg gag gcc agc acc cag acc atc 17087 Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile 1435 1440 1445 aac ttt gac gag cgc tcg cgg tgg ggc ggc cag ctg aaa acc atc 17132 Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile 1450 1455 1460 atg cac acc aac atg ccc aac gtg aac gag ttc atg tac agc aac 17177 Met His Thr Asn Met Pro Asn Val Asn Glu Phe Met Tyr Ser Asn 1465 1470 1475 aag ttc aag gcg cgg gtg atg gtc tcg cgc aag acc ccc aac ggg 17222 Lys Phe Lys Ala Arg Val Met Val Ser Arg Lys Thr Pro Asn Gly 1480 1485 1490 gtg acg gtg gat gag aat tat gat ggt agt cag gac gag ctg acc 17267 Val Thr Val Asp Glu Asn Tyr Asp Gly Ser Gln Asp Glu Leu Thr 1495 1500 1505 tac gag tgg gtg gag ttt gag ctg ccc gag ggc aac ttc tcg gtg 17312 Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn Phe Ser Val 1510 1515 1520 acc atg acc atc gat ctg atg aac aac gcc atc atc gac aac tac 17357 Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr 1525 1530 1535 ttg gcg gtg gga cgg cag aac ggg gtg ctg gag agc gac atc ggc 17402 Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly 1540 1545 1550 gtg aag ttc gac acg cgc aac ttc cgg ctg ggc tgg gac ccc gtg 17447 Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val 1555 1560 1565 acc gag ctg gtg atg ccg ggc gtg tac acc aac gag gcc ttc cac 17492 Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His 1570 1575 1580 ccc gac atc gtc ctg ctg ccc ggc tgc ggc gtg gac ttc acc gag 17537 Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu 1585 1590 1595 agc cgc ctc agc aac ctg ctg ggc atc cgc aag cgg cag ccc ttc 17582 Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe 1600 1605 1610 cag gag ggc ttc cag atc ctg tac gag gac ctg gag ggg ggc aac 17627 Gln Glu Gly Phe Gln Ile Leu Tyr Glu Asp Leu Glu Gly Gly Asn 1615 1620 1625 atc ccc gcg ctg ctg gac gtc gaa gcc tac gag aaa agc aag gag 17672 Ile Pro Ala Leu Leu Asp Val Glu Ala Tyr Glu Lys Ser Lys Glu 1630 1635 1640 gag gcc gcc gca gcg gcg acc gcg gcc gtg gct acc gct gcg acc 17717 Glu Ala Ala Ala Ala Ala Thr Ala Ala Val Ala Thr Ala Ala Thr 1645 1650 1655 acc gat gca gat gca gct act act acc agg ggc gat aca ttc gcc 17762 Thr Asp Ala Asp Ala Ala Thr Thr Thr Arg Gly Asp Thr Phe Ala 1660 1665 1670 acc cag gcg gag gaa gca gcc gcc cta gcg gcg acc gat gat agt 17807 Thr Gln Ala Glu Glu Ala Ala Ala Leu Ala Ala Thr Asp Asp Ser 1675 1680 1685 gaa agt aag ata gtc atc aag ccg gtg gag aag gac agc aag gac 17852 Glu Ser Lys Ile Val Ile Lys Pro Val Glu Lys Asp Ser Lys Asp 1690 1695 1700 agg agc tac aac gtt cta tcg gat gga aag aac acc gcc tac cgc 17897 Arg Ser Tyr Asn Val Leu Ser Asp Gly Lys Asn Thr Ala Tyr Arg 1705 1710 1715 agc tgg tac ctg gcc tac aac tac ggc gac cct gag aag ggc gtg 17942 Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly Asp Pro Glu Lys Gly Val 1720 1725 1730 cgc tcc tgg acg ctg ctc acc acc tcg gac gtc acc tgc ggc gtg 17987 Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp Val Thr Cys Gly Val 1735 1740 1745 gag caa gtc tac tgg tcg ctg ccc gac atg atg caa gac ccg gtc 18032 Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met Gln Asp Pro Val 1750 1755 1760 acc ttc cgc tcc acg cgt caa gtt agc aac tac ccg gtg gtg ggc 18077 Thr Phe Arg Ser Thr Arg Gln Val Ser Asn Tyr Pro Val Val Gly 1765 1770 1775 gcc gag ctc ctg ccc gtc tac tcc aag agc ttc ttc aac gag cag 18122 Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser Phe Phe Asn Glu Gln 1780 1785 1790 gcc gtc tac tcg cag cag ctg cgc gcc ttc acc tcg ctc acg cac 18167 Ala Val Tyr Ser Gln Gln Leu Arg Ala Phe Thr Ser Leu Thr His 1795 1800 1805 gtc ttc aac cgc ttc ccc gag aac cag atc ctc gtc cgc ccg ccc 18212 Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Val Arg Pro Pro 1810 1815 1820 gcg ccc acc att acc acc gtc agt gaa aac gtt cct gct ctc aca 18257 Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr 1825 1830 1835 gat cac ggg acc ctg ccg ctg cgc agc agt atc cgg gga gtc cag 18302 Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln 1840 1845 1850 cgc gtg acc gtc act gac gcc aga cgc cgc acc tgc ccc tac gtc 18347 Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val 1855 1860 1865 tac aag gcc ctg ggc gta gtc gcg ccg cgc gtc ctc tcg agc cgc 18392 Tyr Lys Ala Leu Gly Val Val Ala Pro Arg Val Leu Ser Ser Arg 1870 1875 1880 acc ttc taaaaa atg tcc att ctc atc tcg ccc agt aat aac acc ggt 18440 Thr Phe Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly 1885 1890 1895 tgg ggc ctg cgc gcg ccc agc aag atg tac gga ggc gct cgc caa 18485 Trp Gly Leu Arg Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln 1900 1905 1910 cgc tcc acg caa cac ccc gtg cgc gtg cgc ggg cac ttc cgc gct 18530 Arg Ser Thr Gln His Pro Val Arg Val Arg Gly His Phe Arg Ala 1915 1920 1925 ccc tgg ggc gcc ctc aag ggc cgc gtg cgc tcg cgc acc acc gtc 18575 Pro Trp Gly Ala Leu Lys Gly Arg Val Arg Ser Arg Thr Thr Val 1930 1935 1940 gac gac gtg atc gac cag gtg gtg gcc gac gcg cgc aac tac acg 18620 Asp Asp Val Ile Asp Gln Val Val Ala Asp Ala Arg Asn Tyr Thr 1945 1950 1955 ccc gcc gcc gcg ccc gcc tcc acc gtg gac gcc gtc atc gac agc 18665 Pro Ala Ala Ala Pro Ala Ser Thr Val Asp Ala Val Ile Asp Ser 1960 1965 1970 gtg gtg gcc gac gcg cgc cgg tac gcc cgc gcc aag agc cgg cgg 18710 Val Val Ala Asp Ala Arg Arg Tyr Ala Arg Ala Lys Ser Arg Arg 1975 1980 1985 cgg cgc atc gcc cgg cgg cac cgg agc acc ccc gcc atg cgc gcg 18755 Arg Arg Ile Ala Arg Arg His Arg Ser Thr Pro Ala Met Arg Ala 1990 1995 2000 gcg cga gcc ttg ctg cgc agg gcc agg cgc acg gga cgc agg gcc 18800 Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr Gly Arg Arg Ala 2005 2010 2015 atg ctc agg gcg gcc aga cgc gcg gcc tcc ggc agc agc agc gcc 18845 Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ser Ser Ser Ala 2020 2025 2030 ggc agg acc cgc aga cgc gcg gcc acg gcg gcg gcg gcg gcc atc 18890 Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala Ala Ile 2035 2040 2045 gcc agc atg tcc cgc ccg cgg cgc ggc aac gtg tac tgg gtg cgc 18935 Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val Arg 2050 2055 2060 gac gcc gcc acc ggt gtg cgc gtg ccc gtg cgc acc cgc ccc cct 18980 Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro 2065 2070 2075 cgc act tgaagatgct gacttcgcga tgttgatgtg tcccagcggc gaggagg atg 19036 Arg Thr Met tcc aag cgc aaa ttc aag gaa gag atg ctc cag gtc atc gcg cct 19081 Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 2080 2085 2090 gag atc tac ggc ccc gcg gcg gcg gtg aag gag gaa aga aag ccc 19126 Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys Glu Glu Arg Lys Pro 2095 2100 2105 cgc aaa ctg aag cgg gtc aaa aag gac aaa aag gag gag gaa gat 19171 Arg Lys Leu Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Glu Asp 2110 2115 2120 gac gga ctg gtg gag ttt gtg cgc gag ttc gcc ccc cgg cgg cgc 19216 Asp Gly Leu Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg 2125 2130 2135 gtg cag tgg cgc ggg cgg aaa gtg aaa ccg gtg ctg cgg ccc ggc 19261 Val Gln Trp Arg Gly Arg Lys Val Lys Pro Val Leu Arg Pro Gly 2140 2145 2150 acc acg gtg gtc ttc acg ccc ggc gag cgt tcc ggc tcc gcc tcc 19306 Thr Thr Val Val Phe Thr Pro Gly Glu Arg Ser Gly Ser Ala Ser 2155 2160 2165 aag cgc tcc tac gac gag gtg tac ggg gac gag gac atc ctc gag 19351 Lys Arg Ser Tyr Asp Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu 2170 2175 2180 cag gcg gcc gag cgt ctg ggc gag ttt gct tac ggc aag cgc agc 19396 Gln Ala Ala Glu Arg Leu Gly Glu Phe Ala Tyr Gly Lys Arg Ser 2185 2190 2195 cgc ccc gcg ccc ttg aaa gag gag gcg gtg tcc atc ccg ctg gac 19441 Arg Pro Ala Pro Leu Lys Glu Glu Ala Val Ser Ile Pro Leu Asp 2200 2205 2210 cac ggc aac ccc acg ccg agc ctg aag ccg gtg acc ctg cag cag 19486 His Gly Asn Pro Thr Pro Ser Leu Lys Pro Val Thr Leu Gln Gln 2215 2220 2225 gtg ctg ccg agc gcg gcg ccg cgc cgg ggc ttc aag cgc gag ggc 19531 Val Leu Pro Ser Ala Ala Pro Arg Arg Gly Phe Lys Arg Glu Gly 2230 2235 2240 ggc gag gat ctg tac ccg acc atg cag ctg atg gtg ccc aag cgc 19576 Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met Val Pro Lys Arg 2245 2250 2255 cag aag ctg gag gac gtg ctg gag cac atg aag gtg gac ccc gag 19621 Gln Lys Leu Glu Asp Val Leu Glu His Met Lys Val Asp Pro Glu 2260 2265 2270 gtg cag ccc gag gtc aag gtg cgg ccc atc aag cag gtg gcc ccg 19666 Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln Val Ala Pro 2275 2280 2285 ggc ctg ggc gtg cag acc gtg gac atc aag atc ccc acg gag ccc 19711 Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr Glu Pro 2290 2295 2300 atg gaa acg cag acc gag ccc gtg aag ccc agc acc agc acc atg 19756 Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr Met 2305 2310 2315 gag gtg cag acg gat ccc tgg atg ccg gcg ccg gct tcc acc acc 19801 Glu Val Gln Thr Asp Pro Trp Met Pro Ala Pro Ala Ser Thr Thr 2320 2325 2330 acc acc acc cgc cga aga cgc aag tac ggc gcg gcc agc ctg ctg 19846 Thr Thr Thr Arg Arg Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu 2335 2340 2345 atg ccc aac tac gcg ctg cat cct tcc atc atc ccc acg ccg ggc 19891 Met Pro Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly 2350 2355 2360 tac cgc ggc acg cgc ttc tac cgc ggc tac agc agc cgc cgc aag 19936 Tyr Arg Gly Thr Arg Phe Tyr Arg Gly Tyr Ser Ser Arg Arg Lys 2365 2370 2375 acc acc acc cgc cgc cgc cgt cgc cgc acc cgc cgc agc acc acc 19981 Thr Thr Thr Arg Arg Arg Arg Arg Arg Thr Arg Arg Ser Thr Thr 2380 2385 2390 gcg act tcc gcc gcc gcc ttg gtg cgg aga gtg tac cgc agc ggg 20026 Ala Thr Ser Ala Ala Ala Leu Val Arg Arg Val Tyr Arg Ser Gly 2395 2400 2405 cgt gag cct ctg acc ctg ccg cgc gcg cgc tac cac ccg agc atc 20071 Arg Glu Pro Leu Thr Leu Pro Arg Ala Arg Tyr His Pro Ser Ile 2410 2415 2420 gcc att taactctgcc gtcgcctcct tgcagat atg gcc ctc aca tgc cgc 20122 Ala Ile Met Ala Leu Thr Cys Arg 2425 2430 ctc cgc gtc ccc att acg ggc tac cga gga aga aag ccg cgc cgt 20167 Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly Arg Lys Pro Arg Arg 2435 2440 2445 aga agg ctg acg ggg aac ggg ctg cgt cgc cat cac cac cgg cgg 20212 Arg Arg Leu Thr Gly Asn Gly Leu Arg Arg His His His Arg Arg 2450 2455 2460 cgg cgc gcc atc agc aag cgg ttg ggg gga ggc ttc ctg ccc gcg 20257 Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe Leu Pro Ala 2465 2470 2475 ctg atc ccc atc atc gcc gcg gcg atc ggg gcg atc ccc ggc ata 20302 Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro Gly Ile 2480 2485 2490 gct tcc gtg gcg gtg cag gcc tct cag cgc cac tgagacacag 20345 Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 2495 2500 cttggaaaat ttgtaataaa aaaatggact gacgctcctg gtcctgtgat gtgtgttttt 20405 ag atg gaa gac atc aat ttt tcg tcc ctg gca ccg cga cac ggc acg 20452 Met Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr 2505 2510 2515 cgg ccg ttt atg ggc acc tgg agc gac atc ggc aac agc caa ctg 20497 Arg Pro Phe Met Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu 2520 2525 2530 aac ggg ggc gcc ttc aat tgg agc agt ctc tgg agc ggg ctt aag 20542 Asn Gly Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys 2535 2540 2545 aat ttc ggg tcc acg ctc aaa acc tat ggc agc aag gcg tgg aac 20587 Asn Phe Gly Ser Thr Leu Lys Thr Tyr Gly Ser Lys Ala Trp Asn 2550 2555 2560 agc acc aca ggg cag gcg ctg agg gat aag ctg aaa gag cag aac 20632 Ser Thr Thr Gly Gln Ala Leu Arg Asp Lys Leu Lys Glu Gln Asn 2565 2570 2575 ttc cag cag aag gtg gtc gat ggg ctc gct tcg ggc atc aac ggg 20677 Phe Gln Gln Lys Val Val Asp Gly Leu Ala Ser Gly Ile Asn Gly 2580 2585 2590 gtg gtg gac ctg gcc aac cag gcc gtg cag cgg cag atc aac agc 20722 Val Val Asp Leu Ala Asn Gln Ala Val Gln Arg Gln Ile Asn Ser 2595 2600 2605 cgc ctg gac ccg gtg ccg ccc gcc ggc tcc gtg gag atg ccg cag 20767 Arg Leu Asp Pro Val Pro Pro Ala Gly Ser Val Glu Met Pro Gln 2610 2615 2620 gtg gag gag gag ctg cct ccc ctg gac aag cgg ggc gag aag cga 20812 Val Glu Glu Glu Leu Pro Pro Leu Asp Lys Arg Gly Glu Lys Arg 2625 2630 2635 ccc cgc ccc gac gcg gag gag acg ctg ctg acg cac acg gac gag 20857 Pro Arg Pro Asp Ala Glu Glu Thr Leu Leu Thr His Thr Asp Glu 2640 2645 2650 ccg ccc ccg tac gag gag gcg gtg aaa ctg ggt ctg ccc acc acg 20902 Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu Gly Leu Pro Thr Thr 2655 2660 2665 cgg ccc att gcg ccc cta gcc acc ggg gtg ctg aaa ccc gag agt 20947 Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu Lys Pro Glu Ser 2670 2675 2680 aat aag ccc gcg acc ctg gac ttg cct cct ccc cag cct tcc cgc 20992 Asn Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Gln Pro Ser Arg 2685 2690 2695 ccc tcc aca gtg gct aag ccc ctg ccg ccg gtg gcc gtg gcc cgc 21037 Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val Ala Arg 2700 2705 2710 gcg cga ccc ggg ggc tcc gcc cgc cct cat gcg aac tgg cag agc 21082 Ala Arg Pro Gly Gly Ser Ala Arg Pro His Ala Asn Trp Gln Ser 2715 2720 2725 act ctg aac agc atc gtg ggt ctg gga gtg cag agt gtg aag cgc 21127 Thr Leu Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg 2730 2735 2740 cgc cgc tgc tat taaacctacc gtagcgctta acttgcttgt ctgtgtgtgt 21179 Arg Arg Cys Tyr 2745 atgtattatg tcgccgccgc tgtccgccag aaggaggagt gaagaggcgc gtcgccgagt 21239 tgcaag atg gcc acc cca tcg atg ctg ccc cag tgg gcg tac atg cac 21287 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His 2750 2755 2760 atc gcc gga cag gac gct tcg gag tac ctg agt ccg ggt ctg gtg 21332 Ile Ala Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val 2765 2770 2775 cag ttc gcc cgc gcc aca gac acc tac ttc agt ctg ggg aac aag 21377 Gln Phe Ala Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys 2780 2785 2790 ttt agg aac ccc acg gtg gcg ccc acg cac gat gtg acc acc gac 21422 Phe Arg Asn Pro Thr Val Ala Pro Thr His Asp Val Thr Thr Asp 2795 2800 2805 cgc agc cag cgg ctg acg ctg cgc ttc gtg ccc gtg gac cgc gag 21467 Arg Ser Gln Arg Leu Thr Leu Arg Phe Val Pro Val Asp Arg Glu 2810 2815 2820 gac aac acc tac tcg tac aaa gtg cgc tac acg ctg gcc gtg ggc 21512 Asp Asn Thr Tyr Ser Tyr Lys Val Arg Tyr Thr Leu Ala Val Gly 2825 2830 2835 gac aac cgc gtg ctg gac atg gcc agc acc tac ttt gac atc cgc 21557 Asp Asn Arg Val Leu Asp Met Ala Ser Thr Tyr Phe Asp Ile Arg 2840 2845 2850 ggc gtg ctg gac cgg ggc cct agc ttc aaa ccc tac tcc ggc acc 21602 Gly Val Leu Asp Arg Gly Pro Ser Phe Lys Pro Tyr Ser Gly Thr 2855 2860 2865 gcc tac aac agc ctg gct ccc aag gga gcg ccc aat tcc agc cag 21647 Ala Tyr Asn Ser Leu Ala Pro Lys Gly Ala Pro Asn Ser Ser Gln 2870 2875 2880 tgg gag cga gct aag aca aac aat aac gga gcc acg gaa tct gtt 21692 Trp Glu Arg Ala Lys Thr Asn Asn Asn Gly Ala Thr Glu Ser Val 2885 2890 2895 acc ttt ggt gtg gct gcc atg ggg ggt ata gat att aca aaa gag 21737 Thr Phe Gly Val Ala Ala Met Gly Gly Ile Asp Ile Thr Lys Glu 2900 2905 2910 ggt ctc cag att gga act gat gaa act aaa gct gat agt aaa gaa 21782 Gly Leu Gln Ile Gly Thr Asp Glu Thr Lys Ala Asp Ser Lys Glu 2915 2920 2925 att tat gca gac aaa acc tac caa cct gaa cct cag ata gga gag 21827 Ile Tyr Ala Asp Lys Thr Tyr Gln Pro Glu Pro Gln Ile Gly Glu 2930 2935 2940 gag aac tgg caa gaa aca ttc tcc tat tat ggc ggc aga gct ctt 21872 Glu Asn Trp Gln Glu Thr Phe Ser Tyr Tyr Gly Gly Arg Ala Leu 2945 2950 2955 aaa aaa gat acc aag atg aag cca tgc tac ggc tcc ttt gct aaa 21917 Lys Lys Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys 2960 2965 2970 cca acg aat gtc aaa gga ggt cag gcc aaa ttt aaa gtt cag gac 21962 Pro Thr Asn Val Lys Gly Gly Gln Ala Lys Phe Lys Val Gln Asp 2975 2980 2985 ggt caa caa act aca gaa tat gat atc gac tta gct ttc ttt gat 22007 Gly Gln Gln Thr Thr Glu Tyr Asp Ile Asp Leu Ala Phe Phe Asp 2990 2995 3000 att cca aac tct gga aca gga ggg aat ggc acg aat gtt aat tat 22052 Ile Pro Asn Ser Gly Thr Gly Gly Asn Gly Thr Asn Val Asn Tyr 3005 3010 3015 gat cca gat atg gtc atg tac act gaa aat gtg gat ttg gag acc 22097 Asp Pro Asp Met Val Met Tyr Thr Glu Asn Val Asp Leu Glu Thr 3020 3025 3030 cct gat acc cac att gtt tac aaa cca ggg act tcc gat gac agt 22142 Pro Asp Thr His Ile Val Tyr Lys Pro Gly Thr Ser Asp Asp Ser 3035 3040 3045 tct gaa gca aac ttg ctt cag cag tcc atg cct aac aga ccc aac 22187 Ser Glu Ala Asn Leu Leu Gln Gln Ser Met Pro Asn Arg Pro Asn 3050 3055 3060 tat att ggg ttt aga gac aac ttt atc ggt ctc atg tac tac aac 22232 Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn 3065 3070 3075 agt act ggc aat atg ggt gtg ctg gct ggt cag gcc tcc cag ctg 22277 Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu 3080 3085 3090 aat gct gtg gtc gac ttg caa gac aga aac acc gag cta tcc tac 22322 Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr 3095 3100 3105 cag ctc ttg ctt gac tct ctg ggc gat aga acc cgg tat ttc agt 22367 Gln Leu Leu Leu Asp Ser Leu Gly Asp Arg Thr Arg Tyr Phe Ser 3110 3115 3120 atg tgg aac cag gcg gtg gac agt tat gac cct gat gtg cgc att 22412 Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile 3125 3130 3135 att gaa aac cat ggt gtg gaa gat gaa ctt ccc aac tat tgc ttc 22457 Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe 3140 3145 3150 cca ttg gat gga gct ggt act aat gct gtc tat cag ggt gtt aaa 22502 Pro Leu Asp Gly Ala Gly Thr Asn Ala Val Tyr Gln Gly Val Lys 3155 3160 3165 gca aaa act aat gga ggc gca gcc aat gga gat tgg gag caa gat 22547 Ala Lys Thr Asn Gly Gly Ala Ala Asn Gly Asp Trp Glu Gln Asp 3170 3175 3180 aca gac gtg tca aac att aac cag ata tgc aag ggg aac atc tat 22592 Thr Asp Val Ser Asn Ile Asn Gln Ile Cys Lys Gly Asn Ile Tyr 3185 3190 3195 gcc atg gaa atc aac ctc caa gcc aac ctg tgg aga agt ttc ctc 22637 Ala Met Glu Ile Asn Leu Gln Ala Asn Leu Trp Arg Ser Phe Leu 3200 3205 3210 tac tcg aac gtg gcc ctg tac ctg ccc gat tct tac aag tac acg 22682 Tyr Ser Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr 3215 3220 3225 ccg gcc aac atc acc ttg ccc acg aat acc aac acc tat gat tac 22727 Pro Ala Asn Ile Thr Leu Pro Thr Asn Thr Asn Thr Tyr Asp Tyr 3230 3235 3240 atg aat ggg aga gtg gcg cct ccc tcg ttg gtg gat gcc tac atc 22772 Met Asn Gly Arg Val Ala Pro Pro Ser Leu Val Asp Ala Tyr Ile 3245 3250 3255 aac atc ggg gcg cgc tgg tcg ctg gac ccc atg gac aac gtc aat 22817 Asn Ile Gly Ala Arg Trp Ser Leu Asp Pro Met Asp Asn Val Asn 3260 3265 3270 ccc ttc aac cac cac cgc aac gcg ggg ctg cgc tac cgc tcc atg 22862 Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met 3275 3280 3285 ctt ctg ggc aac ggg cgc ttc gtg ccc ttc cac atc cag gtg ccc 22907 Leu Leu Gly Asn Gly Arg Phe Val Pro Phe His Ile Gln Val Pro 3290 3295 3300 cag aaa ttt ttc gcc atc aag agc ctc ctg ctc ctg ccc ggg tcc 22952 Gln Lys Phe Phe Ala Ile Lys Ser Leu Leu Leu Leu Pro Gly Ser 3305 3310 3315 tac acc tac gag tgg aac ttc cgc aag gac gtc aac atg atc ctg 22997 Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met Ile Leu 3320 3325 3330 cag agc tcc ctc ggc aac gac ctg cgc acg gac ggg gcc tcc atc 23042 Gln Ser Ser Leu Gly Asn Asp Leu Arg Thr Asp Gly Ala Ser Ile 3335 3340 3345 tcc ttc acc agc atc aac ctc tac gcc acc ttc ttc ccc atg gcg 23087 Ser Phe Thr Ser Ile Asn Leu Tyr Ala Thr Phe Phe Pro Met Ala 3350 3355 3360 cac aac acg gcc tcc acg ctc gag gcc atg ctg cgc aac gac acc 23132 His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr 3365 3370 3375 aac gac cag tcc ttc aac gac tac ctc tcg gcg gcc aac atg ctc 23177 Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu 3380 3385 3390 tac ccc atc cca gcc aac gcc acc aac gtg ccc atc tcc atc ccc 23222 Tyr Pro Ile Pro Ala Asn Ala Thr Asn Val Pro Ile Ser Ile Pro 3395 3400 3405 tcg cgc aac tgg gcc gcc ttc cgc ggc tgg tcc ttc acg cgt ctc 23267 Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu 3410 3415 3420 aag acc aag gag acg ccc tcg ctg ggc tcc ggg ttc gac ccc tac 23312 Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro Tyr 3425 3430 3435 ttc gtc tac tcg ggc tcc atc ccc tac ctc gac ggc acc ttc tac 23357 Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr 3440 3445 3450 ctc aac cac acc ttc aag aag gtc tcc atc acc ttc gac tcc tcc 23402 Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe Asp Ser Ser 3455 3460 3465 gtc agc tgg ccc ggc aac gac cgg ctc ctg acg ccc aac gag ttc 23447 Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe 3470 3475 3480 gaa atc aag cgc acc gtc gac ggc gag ggc tac aac gtg gcc cag 23492 Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn Val Ala Gln 3485 3490 3495 tgc aac atg acc aag gac tgg ttc ctg gtc cag atg ctg gcc cac 23537 Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala His 3500 3505 3510 tac aac atc ggc tac cag ggc ttc tac gtg ccc gag ggc tac aag 23582 Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys 3515 3520 3525 gac cgc atg tac tcc ttc ttc cgc aac ttc cag ccc atg agc cgc 23627 Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg 3530 3535 3540 cag gtg gtg gac gag gtc aac tac aag gac tac cag gcc gtc acc 23672 Gln Val Val Asp Glu Val Asn Tyr Lys Asp Tyr Gln Ala Val Thr 3545 3550 3555 ctg gcc tac cag cac aac aac tcg ggc ttc gtc ggc tac ctc gcg 23717 Leu Ala Tyr Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala 3560 3565 3570 ccc acc atg cgc cag ggc cag ccc tac ccc gcc aac tac ccg tac 23762 Pro Thr Met Arg Gln Gly Gln Pro Tyr Pro Ala Asn Tyr Pro Tyr 3575 3580 3585 ccg ctc atc ggc aag agc gcc gtc acc agc gtc acc cag aaa aag 23807 Pro Leu Ile Gly Lys Ser Ala Val Thr Ser Val Thr Gln Lys Lys 3590 3595 3600 ttc ctc tgc gac agg gtc atg tgg cgc atc ccc ttc tcc agc aac 23852 Phe Leu Cys Asp Arg Val Met Trp Arg Ile Pro Phe Ser Ser Asn 3605 3610 3615 ttc atg tcc atg ggc gcg ctc acc gac ctc ggc cag aac atg ctc 23897 Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Met Leu 3620 3625 3630 tat gcc aac tcc gcc cac gcg cta gac atg aat ttc gaa gtc gac 23942 Tyr Ala Asn Ser Ala His Ala Leu Asp Met Asn Phe Glu Val Asp 3635 3640 3645 ccc atg gat gag tcc acc ctt ctc tat gtt gtc ttc gaa gtc ttc 23987 Pro Met Asp Glu Ser Thr Leu Leu Tyr Val Val Phe Glu Val Phe 3650 3655 3660 gac gtc gtc cga gtg cac cag ccc cac cgc ggc gtc atc gag gcc 24032 Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Ala 3665 3670 3675 gtc tac ctg cgc acc ccc ttc tcg gcc ggt aac gcc acc acc 24074 Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 3680 3685 taagctcttg cttcttgcaa g atg gct gag ccc acg ggc tcc ggc gag cag 24125 Met Ala Glu Pro Thr Gly Ser Gly Glu Gln 3690 3695 gag ctc agg gcc atc atc cgc gac ctg ggc tgc ggg ccc tac ttc 24170 Glu Leu Arg Ala Ile Ile Arg Asp Leu Gly Cys Gly Pro Tyr Phe 3700 3705 3710 ctg ggc acc ttc gat aag cgc ttc ccg gga ttc atg gcc ccg cac 24215 Leu Gly Thr Phe Asp Lys Arg Phe Pro Gly Phe Met Ala Pro His 3715 3720 3725 aag ctg gcc tgc gcc atc gtc aac acg gcc ggc cgc gag acc ggg 24260 Lys Leu Ala Cys Ala Ile Val Asn Thr Ala Gly Arg Glu Thr Gly 3730 3735 3740 ggc gag cac tgg ctg gcc ttc gcc tgg aac ccg cgc tcg aac acc 24305 Gly Glu His Trp Leu Ala Phe Ala Trp Asn Pro Arg Ser Asn Thr 3745 3750 3755 tgc tac ctc ttc gac ccc ttc ggg ttc tcg gac gag cgc ctc aag 24350 Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser Asp Glu Arg Leu Lys 3760 3765 3770 cag atc tac cag ttc gag tac gag ggc ctg ctg cgc cgc agc gcc 24395 Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu Leu Arg Arg Ser Ala 3775 3780 3785 ctg gcc acc gag gac cgc tgc gtc acc ctg gaa aag tcc acc cag 24440 Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu Lys Ser Thr Gln 3790 3795 3800 acc gtg cag ggt ccg cgc tcg gcc gcc tgc ggg ctc ttt tgc tgc 24485 Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu Phe Cys Cys 3805 3810 3815 atg ttc ctg cac gcc ttc gtg cac tgg ccc gac cgc ccc atg gac 24530 Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro Met Asp 3820 3825 3830 aag aac ccc acc atg aac ttg ctg acg ggg gtg ccc aac ggc atg 24575 Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly Met 3835 3840 3845 ctc cag tcg ccc cag gtg gaa ccc acc ctg cgc cgc aac cag gag 24620 Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu 3850 3855 3860 gcg ctc tac cgc ttc ctc aac gcc cac tcc gcc tac ttt cgc tcc 24665 Ala Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe Arg Ser 3865 3870 3875 cac cgc gcg cgc atc gag aag gcc acc gcc ttc gac cgc atg aat 24710 His Arg Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn 3880 3885 3890 caa gac atg taaaccgtgt gtgtatgtga atgctttatt cataataaac 24759 Gln Asp Met 3895 agcacatgtt tatgccacct tctctgaggc tctgacttta tttagaaatc gaaggggttc 24819 tgccggctct cggcgtgccc cgcgggcagg gatacgttgc ggaactggta cttgggcagc 24879 cacttgaact cggggatcag cagcttcggc acggggaggt cggggaacga gtcgctccac 24939 agcttgcgcg tgagttgcag ggcgcccagc aggtcgggcg cggagatctt gaaatcgcag 24999 ttgggacccg cgttctgcgc gcgagagttg cggtacacgg ggttgcagca ctggaacacc 25059 atcagggccg ggtgcttcac gctcgccagc accgtcgcgt cggtgatgcc ctccacgtcc 25119 agatcctcgg cgttggccat cccgaagggg gtcatcttgc aggtctgccg ccccatgctg 25179 ggcacgcagc cgggcttgtg gttgcaatcg cagtgcaggg ggatcagcat catctgggcc 25239 tgctcggagc tcatgcccgg gtacatggcc ttcatgaaag cctccagctg gcggaaggcc 25299 tgctgcgcct tgccgccctc ggtgaagaag accccgcagg acttgctaga gaactggttg 25359 gtagcgcagc ccgcgtcgtg cacgcagcag cgcgcgtcgt tgttggccag ctgcaccacg 25419 ctgcgccccc agcggttctg ggtgatcttg gcccggtcgg ggttctcctt cagcgcgcgc 25479 tgcccgttct cgctcgccac atccatctcg atcgtgtgct ccttctggat catcacggtc 25539 ccgtgcaggc accgcagctt gccctcggcc tcggtgcagc cgtgcagcca cagcgcgcag 25599 ccggtgctct cccagttctt gtgggcgatc tgggagtgcg agtgcacgaa gccctgcagg 25659 aagcggccca tcatcgcggt cagggtcttg ttgctggtga aggtcagcgg gatgccgcgg 25719 tgctcctcgt tcacatacag gtggcagatg cggcggtaca cctcgccctg ctcgggcatc 25779 agctggaagg cggacttcag gtcgctctcc acgcggtacc ggtccatcag cagcgtcatc 25839 acttccatgc ccttctccca ggccgaaacg atcggcaggc tcagggggtt cttcaccgtc 25899 atcttagtcg ccgccgccga agtcaggggg tcgttctcgt ccagggtctc aaacactcgc 25959 ttgccgtcct tctcggtgat gcgcacgggg gggaaggcga agcccacggc cgccagctcc 26019 tcctcggcct gcctttcgtc ctcgctgtcc tggctgatgt cttgcaaagg cacatgcttg 26079 gtcttgcggg gtttcttttt gggcggcaga ggcggcggcg gcggagacgt gctgggcgag 26139 cgcgagttct cgctcaccac gactatttct tcttcttggc cgtcgtccga gaccacgcgg 26199 cggtaggcat gcctcttctg gggcagaggc ggaggcgacg ggctctcgcg gttcggcggg 26259 cggctggcag agccccttcc gcgttcgggg gtgcgctcct ggcggcgctg ctctgactga 26319 cttcctccgc ggccggccat tgtgttctcc tagggagcaa caacaagc atg gag act 26376 Met Glu Thr 3900 cag cca tcg tcg cca aca tcg cca tct gcc ccc gcc gcc gcc gac 26421 Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ala Ala Asp 3905 3910 3915 gag aac cag cag cag cag aat gaa agc tta acc gcc ccg ccg ccc 26466 Glu Asn Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro Pro 3920 3925 3930 agc ccc acc tcc gac gcc gcg gcc cca gac atg caa gag atg gag 26511 Ser Pro Thr Ser Asp Ala Ala Ala Pro Asp Met Gln Glu Met Glu 3935 3940 3945 gaa tcc atc gag att gac ctg ggc tac gtg acg ccc gcg gag cac 26556 Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His 3950 3955 3960 gag gag gag ctg gca gcg cgc ttt tca gcc ccg gaa gag aac cac 26601 Glu Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His 3965 3970 3975 caa gag cag cca gag cag gaa gca gag agc gag cag agc cag gct 26646 Gln Glu Gln Pro Glu Gln Glu Ala Glu Ser Glu Gln Ser Gln Ala 3980 3985 3990 ggg ctc gag cat ggc gac tac ctg agc ggg gca gag gac gtg ctc 26691 Gly Leu Glu His Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu 3995 4000 4005 atc aag cat ctg gcc cgc caa tgc atc atc gtc aag gac gcg ctg 26736 Ile Lys His Leu Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu 4010 4015 4020 ctc gac cgc gcc gag gtg ccc ctc agc gtg gcg gag ctc agc cgc 26781 Leu Asp Arg Ala Glu Val Pro Leu Ser Val Ala Glu Leu Ser Arg 4025 4030 4035 gcc tac gag cgc aac ctc ttc tcg ccg cgc gtg ccc ccc aag cgc 26826 Ala Tyr Glu Arg Asn Leu Phe Ser Pro Arg Val Pro Pro Lys Arg 4040 4045 4050 cag ccc aac ggc acc tgc gag ccc aac ccg cgc ctc aac ttc tac 26871 Gln Pro Asn Gly Thr Cys Glu Pro Asn Pro Arg Leu Asn Phe Tyr 4055 4060 4065 ccg gtc ttc gcg gtg ccc gag gcc ctg gcc acc tac cac ctc ttt 26916 Pro Val Phe Ala Val Pro Glu Ala Leu Ala Thr Tyr His Leu Phe 4070 4075 4080 ttc aag aac caa agg atc ccc gtc tcc tgc cgc gcc aac cgc acc 26961 Phe Lys Asn Gln Arg Ile Pro Val Ser Cys Arg Ala Asn Arg Thr 4085 4090 4095 cgc gcc gac gcc ctg ctc aac ctg ggc ccc ggc gcc cgc cta cct 27006 Arg Ala Asp Ala Leu Leu Asn Leu Gly Pro Gly Ala Arg Leu Pro 4100 4105 4110 gat atc gcc tcc ttg gaa gag gtt ccc aag atc ttc gag ggt ctg 27051 Asp Ile Ala Ser Leu Glu Glu Val Pro Lys Ile Phe Glu Gly Leu 4115 4120 4125 ggc agc gac gag act cgg gcc gcg aac gct ctg caa gga agc gga 27096 Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu Gln Gly Ser Gly 4130 4135 4140 gag gag cat gag cac cac agc gcc ctg gtg gag ttg gaa ggc gac 27141 Glu Glu His Glu His His Ser Ala Leu Val Glu Leu Glu Gly Asp 4145 4150 4155 aac gcg cgc ctg gcg gtc ctc aag cgc acg gtc gag ctg acc cac 27186 Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu Thr His 4160 4165 4170 ttc gcc tac ccg gcg ctc aac ctg ccc ccc aag gtc atg agc gcc 27231 Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser Ala 4175 4180 4185 gtc atg gac cag gtg ctc atc aag cgc gcc tcg ccc ctc tcg gag 27276 Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu 4190 4195 4200 gag gag atg cag gac ccc gag agc tcg gac gag ggc aag ccc gtg 27321 Glu Glu Met Gln Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val 4205 4210 4215 gtc agc gac gag cag ctg gcg cgc tgg ctg gga acg agt agc acc 27366 Val Ser Asp Glu Gln Leu Ala Arg Trp Leu Gly Thr Ser Ser Thr 4220 4225 4230 ccc cag agt ctg gaa gag cgg cgc aag ctc atg atg gcc gtg gtc 27411 Pro Gln Ser Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val 4235 4240 4245 ctg gtg acc gtg gag ctt gag tgt ctg cgc cgc ttc ttc gcc gac 27456 Leu Val Thr Val Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp 4250 4255 4260 gcg gag acc ctg cgc aag gtc gag gag aac ctg cac tac ctc ttc 27501 Ala Glu Thr Leu Arg Lys Val Glu Glu Asn Leu His Tyr Leu Phe 4265 4270 4275 agg cac ggg ttc gtg cgc cag gcc tgc aag atc tcc aac gtg gag 27546 Arg His Gly Phe Val Arg Gln Ala Cys Lys Ile Ser Asn Val Glu 4280 4285 4290 ctg acc aac ctg gtc tcc tac atg ggc atc ctg cac gag aac cgc 27591 Leu Thr Asn Leu Val Ser Tyr Met Gly Ile Leu His Glu Asn Arg 4295 4300 4305 ctg ggg cag aac gtg ctg cac acc acc ctg cgc ggg gag gcc cgc 27636 Leu Gly Gln Asn Val Leu His Thr Thr Leu Arg Gly Glu Ala Arg 4310 4315 4320 cgc gac tac atc cgc gac tgc gtc tac ctg tac ctc tgc cac acc 27681 Arg Asp Tyr Ile Arg Asp Cys Val Tyr Leu Tyr Leu Cys His Thr 4325 4330 4335 tgg cag acg ggc atg ggc gtg tgg cag cag tgc ctg gag gag cag 27726 Trp Gln Thr Gly Met Gly Val Trp Gln Gln Cys Leu Glu Glu Gln 4340 4345 4350 aac ctg aaa gag ctc tgc aag ctc ctg cag aag aac ctg aag gcc 27771 Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys Asn Leu Lys Ala 4355 4360 4365 ctg tgg acc ggg ttc gac gag cgt acc acc gcc tcg gac ctg gcc 27816 Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser Asp Leu Ala 4370 4375 4380 gac ctc atc ttc ccc gag cgc ctg cgg ctg acg ctg cgc aac ggg 27861 Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg Asn Gly 4385 4390 4395 ctg ccc gac ttt atg agc caa agc atg ttg caa aac ttt cgc tct 27906 Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg Ser 4400 4405 4410 ttc atc ctc gaa cgc tcc ggg atc ctg ccc gcc acc tgc tcc gcg 27951 Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala 4415 4420 4425 ctg ccc tcg gac ttc gtg ccg ctg acc ttc cgc gag tgc ccc ccg 27996 Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro 4430 4435 4440 ccg ctc tgg agc cac tgc tac ttg ctg cgc ctg gcc aac tac ctg 28041 Pro Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu 4445 4450 4455 gcc tac cac tcg gac gtg atc gag gac gtc agc ggc gag ggt ctg 28086 Ala Tyr His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu 4460 4465 4470 ctc gag tgc cac tgc cgc tgc aac ctc tgc acg ccg cac cgc tcc 28131 Leu Glu Cys His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser 4475 4480 4485 ctg gcc tgc aac ccc cag ctg ctg agc gag acc cag atc atc ggc 28176 Leu Ala Cys Asn Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly 4490 4495 4500 acc ttc gag ttg caa ggc ccc ggc gag gag ggc aag ggg ggt ctg 28221 Thr Phe Glu Leu Gln Gly Pro Gly Glu Glu Gly Lys Gly Gly Leu 4505 4510 4515 aaa ctc acc ccg ggg ctg tgg acc tcg gcc tac ttg cgc aag ttc 28266 Lys Leu Thr Pro Gly Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe 4520 4525 4530 gtg ccc gag gac tac cat ccc ttc gag atc agg ttc tac gag gac 28311 Val Pro Glu Asp Tyr His Pro Phe Glu Ile Arg Phe Tyr Glu Asp 4535 4540 4545 caa tcc cag ccg ccc aag gcc gag ctg tcg gcc tgc gtc atc acc 28356 Gln Ser Gln Pro Pro Lys Ala Glu Leu Ser Ala Cys Val Ile Thr 4550 4555 4560 cag ggg gcc atc ctg gcc caa ttg caa gcc atc cag aaa tcc cgc 28401 Gln Gly Ala Ile Leu Ala Gln Leu Gln Ala Ile Gln Lys Ser Arg 4565 4570 4575 caa gaa ttt ctg ctg aaa aag ggc cac ggg gtc tac ttg gac ccc 28446 Gln Glu Phe Leu Leu Lys Lys Gly His Gly Val Tyr Leu Asp Pro 4580 4585 4590 cag acc gga gag gag ctc aac ccc agc ttc ccc cag gat gcc cag 28491 Gln Thr Gly Glu Glu Leu Asn Pro Ser Phe Pro Gln Asp Ala Gln 4595 4600 4605 agg aag cag caa gaa gct gaa agt gga gct gcc gct gcc gcc gga 28536 Arg Lys Gln Gln Glu Ala Glu Ser Gly Ala Ala Ala Ala Ala Gly 4610 4615 4620 gga ttt gga gga aga ctg gga gag cag tca ggc aga gga gga gga 28581 Gly Phe Gly Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly Gly Gly 4625 4630 4635 gat gga aga ctg gga cag cac tca ggc aga gga gga cag cct gca 28626 Asp Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln Pro Ala 4640 4645 4650 aga cag tct gga aga cga ggt gga gga ggc aga gga aga agc agc 28671 Arg Gln Ser Gly Arg Arg Gly Gly Gly Gly Arg Gly Arg Ser Ser 4655 4660 4665 cgc cgc cag acc gtc gtc ctc ggc gga gaa agc aag cag cac gga 28716 Arg Arg Gln Thr Val Val Leu Gly Gly Glu Ser Lys Gln His Gly 4670 4675 4680 tac cat ctc cgc tcc ggg tcg ggg tct cgg cgg ccg ggc cca cag 28761 Tyr His Leu Arg Ser Gly Ser Gly Ser Arg Arg Pro Gly Pro Gln 4685 4690 4695 tagatgggac gagaccgggc gcttcccgaa ccccaccacc cagaccggta agaaggagcg 28821 gcagggatac aagtcctggc gggggcacaa aaacgccatc gtctcctgct tgcaagcctg 28881 cgggggcaac atctccttca cccggcgcta cctgctcttc caccgcgggg tgaacttccc 28941 ccgcaacatc ttgcattact accgtcacct ccacagcccc tactactgtt tccaagaaga 29001 ggcagaaacc cagcagcagc agaaaaccag cagcagctag aaaatccaca gcggcggcgg 29061 cggcaggtgg actgaggatc gcggcgaacg agccggcgca gacccgggag ctgaggaacc 29121 ggatctttcc caccctctat gccatcttcc agcagagtcg ggggcaggag caggaactga 29181 aagtcaagaa ccgttctctg cgctcgctca cccgcagttg tctgtatcac aagagcgaag 29241 accaacttca gcgcactctc gaggacgccg aggctctctt caacaagtac tgcgcgctca 29301 ctcttaaaga gtagcccgcg cccgcccaca cacggaaaaa ggcgggaatt acgtcaccac 29361 ctgcgccctt cgcccgacca tcatc atg agc aaa gag att ccc acg cct tac 29413 Met Ser Lys Glu Ile Pro Thr Pro Tyr 4700 atg tgg agc tac cag ccc cag atg ggc ctg gcc gcc ggc gcc gcc 29458 Met Trp Ser Tyr Gln Pro Gln Met Gly Leu Ala Ala Gly Ala Ala 4705 4710 4715 cag gac tac tcc acc cgc atg aac tgg ctc agt gcc ggg ccc gcg 29503 Gln Asp Tyr Ser Thr Arg Met Asn Trp Leu Ser Ala Gly Pro Ala 4720 4725 4730 atg atc tca cgg gtg aat gac atc cgc gcc cac cga aac cag ata 29548 Met Ile Ser Arg Val Asn Asp Ile Arg Ala His Arg Asn Gln Ile 4735 4740 4745 ctc cta gaa cag tca gcg atc acc gcc acg ccc cgc cat cac ctt 29593 Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr Pro Arg His His Leu 4750 4755 4760 aat ccg cgt aat tgg ccc gcc gcc ctg gtg tac cag gaa att ccc 29638 Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr Gln Glu Ile Pro 4765 4770 4775 cag ccc acg acc gta cta ctt ccg cga gac gcc cag gcc gaa gtc 29683 Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln Ala Glu Val 4780 4785 4790 cag ctg act aac tca ggt gtc cag ctg gcc ggc ggc gcc gcc ctg 29728 Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala Ala Leu 4795 4800 4805 tgt cgt cac cgc ccc gct cag ggt ata aag cgg ctg gtg atc cga 29773 Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile Arg 4810 4815 4820 ggc aga ggc aca cag ctc aac gac gag gtg gtg agc tct tcg ctg 29818 Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 4825 4830 4835 ggt ctg cga cct gac gga gtc ttc caa ctc gcc gga tcg ggg aga 29863 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg 4840 4845 4850 tct tcc ttc acg cct cgt cag gcc gtc ctg act ttg gag agt tcg 29908 Ser Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser 4855 4860 4865 tcc tcg cag ccc cgc tcg ggt ggc atc ggc act ctc cag ttc gtg 29953 Ser Ser Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val 4870 4875 4880 gag gag ttc act ccc tcg gtc tac ttc aac ccc ttc tcc ggc tcc 29998 Glu Glu Phe Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser 4885 4890 4895 ccc ggc cac tac ccg gac gag ttc atc ccg aac ttc gac gcc atc 30043 Pro Gly His Tyr Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile 4900 4905 4910 agc gag tcg gtg gac ggc tac gat tga atg tcc cat ggt ggc gcg 30088 Ser Glu Ser Val Asp Gly Tyr Asp Met Ser His Gly Gly Ala 4915 4920 4925 gct gac cta gct cgg ctt cga cac ctg gac cac tgc cgc cgc ttc 30133 Ala Asp Leu Ala Arg Leu Arg His Leu Asp His Cys Arg Arg Phe 4930 4935 4940 cgc tgc ttc gct cgg gat ctc gcc gag ttt gcc tac ttt gag ctg 30178 Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Ala Tyr Phe Glu Leu 4945 4950 4955 ccc gag gag cac cct cag ggc ccg gcc cac gga gtg cgg atc atc 30223 Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val Arg Ile Ile 4960 4965 4970 gtc gaa ggg ggc ctc gac tcc cac ctg ctt cgg atc ttc agc cag 30268 Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe Ser Gln 4975 4980 4985 cgt ccg atc ctg gtc gag cgc gag caa gga cag acc cgt ctg acc 30313 Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Arg Leu Thr 4990 4995 5000 ctg tac tgc atc tgc aac cac ccc ggc ctg cat gaa agt ctt tgt 30358 Leu Tyr Cys Ile Cys Asn His Pro Gly Leu His Glu Ser Leu Cys 5005 5010 5015 tgt ctg ctg tgt act gag tat aat aaa agc tgagatcagc gactactccg 30408 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 5020 5025 gacttccgtg tgttcctgaa tccatcaacc agtccctgtt cttcaccggg aacgagaccg 30468 agctccagct ccagtgtaag ccccacaaga agtacctcac ctggctgttc cagggctccc 30528 cgatcgccgt tgtcaaccac tgcgacaacg acggagtcct gctgagcggc cctgccaacc 30588 ttactttttc cacccgcaga agcaagctcc agctcttcca acccttcctc cccgggacct 30648 atcagtgcgt ctcgggaccc tgccatcaca ccttccacct gatcccgaat accacagcgt 30708 cgctccccgc tactaacaac caaactaccc accaacgcca ccgtcgcgac ctttcctctg 30768 aatctaatac cactaccgga ggtgagctcc gaggtcgacc aacctctggg atttactacg 30828 gcccctggga ggtggtgggg ttaatagcgc taggcctagt tgtgggtggg cttttggctc 30888 tctgctacct atacctccct tgctgttcgt acttagtggt gctgtgttgc tggtttaaga 30948 a atg ggg cag atc acc cta gtg agc tgc ggt gtg ctg gtg gcg gtg 30994 Met Gly Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val 5030 5035 5040 gtg ctt tcg att gtg gga ctg ggc ggc gcg gct gta gtg aag gag 31039 Val Leu Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu 5045 5050 5055 aag gcc gat ccc tgc ttg cat ttc aat ccc gat aaa tgc cag ctg 31084 Lys Ala Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu 5060 5065 5070 agt ttt cag ccc gat ggc aat cgg tgc gcg gtg ctg atc aag tgc 31129 Ser Phe Gln Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys 5075 5080 5085 gga tgg gaa tgc gag aac gtg aga atc gag tac aat aac aag act 31174 Gly Trp Glu Cys Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr 5090 5095 5100 cgg aac aat act ctc gcg tcc acg tgg cag ccc ggg gac ccc gag 31219 Arg Asn Asn Thr Leu Ala Ser Thr Trp Gln Pro Gly Asp Pro Glu 5105 5110 5115 tgg tac acc gtc tct gtc ccc ggt gct gac ggc tcc ccg cgc acc 31264 Trp Tyr Thr Val Ser Val Pro Gly Ala Asp Gly Ser Pro Arg Thr 5120 5125 5130 gtg aat aat act ttc att ttt gcg cac atg tgc gac acg gtc atg 31309 Val Asn Asn Thr Phe Ile Phe Ala His Met Cys Asp Thr Val Met 5135 5140 5145 tgg atg agc aag cag tac gat atg tgg ccc ccc acg aag gag aac 31354 Trp Met Ser Lys Gln Tyr Asp Met Trp Pro Pro Thr Lys Glu Asn 5150 5155 5160 atc gtg gtc ttc tcc atc gct tac agc ctg tgc acg gtg cta atc 31399 Ile Val Val Phe Ser Ile Ala Tyr Ser Leu Cys Thr Val Leu Ile 5165 5170 5175 acc gct atc gtg tgc ctg agc att cac atg ctc atc gct att cgc 31444 Thr Ala Ile Val Cys Leu Ser Ile His Met Leu Ile Ala Ile Arg 5180 5185 5190 ccc aga aat aat gcc gaa aaa gaa aaa cag cca taacacgttt 31487 Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 5195 5200 tttcacacac ctttttcaga cc atg gcc tct gtt aaa ttt ttg ctt tta 31536 Met Ala Ser Val Lys Phe Leu Leu Leu 5205 5210 ttt gcc agt ctc att act gtt ata agt aat gag aaa ctc act att 31581 Phe Ala Ser Leu Ile Thr Val Ile Ser Asn Glu Lys Leu Thr Ile 5215 5220 5225 tac att ggc act aac cac act cta gaa gga att cca aaa tcc tca 31626 Tyr Ile Gly Thr Asn His Thr Leu Glu Gly Ile Pro Lys Ser Ser 5230 5235 5240 tgg tat tgc tat ttt gat caa gat cca gac tta act ata gaa ctg 31671 Trp Tyr Cys Tyr Phe Asp Gln Asp Pro Asp Leu Thr Ile Glu Leu 5245 5250 5255 tgt ggt aac aag gga caa aat aca agc att cat tta att aac ttt 31716 Cys Gly Asn Lys Gly Gln Asn Thr Ser Ile His Leu Ile Asn Phe 5260 5265 5270 aaa tgc gga gac gat ttg aaa tta att aat atc act aaa gag tat 31761 Lys Cys Gly Asp Asp Leu Lys Leu Ile Asn Ile Thr Lys Glu Tyr 5275 5280 5285 gga ggt atg tat tac tat gtt aca gaa aat aac aac atg cag ttt 31806 Gly Gly Met Tyr Tyr Tyr Val Thr Glu Asn Asn Asn Met Gln Phe 5290 5295 5300 tat gaa gtt act gta act aat ccc acc acg cct aga aca aca aca 31851 Tyr Glu Val Thr Val Thr Asn Pro Thr Thr Pro Arg Thr Thr Thr 5305 5310 5315 acc acc aca aag act aca cct gtt acc act atg cag ctc act acc 31896 Thr Thr Thr Lys Thr Thr Pro Val Thr Thr Met Gln Leu Thr Thr 5320 5325 5330 aat aac att ttt gcc atg cgt cag aag gcc aac aat agc acc agc 31941 Asn Asn Ile Phe Ala Met Arg Gln Lys Ala Asn Asn Ser Thr Ser 5335 5340 5345 att caa ccc ccc cca ccc agt gag gaa att ccc aaa tcc atg att 31986 Ile Gln Pro Pro Pro Pro Ser Glu Glu Ile Pro Lys Ser Met Ile 5350 5355 5360 ggc att att gtt gct gta gtg gtg tgc atg ttg atc atc gcc ttg 32031 Gly Ile Ile Val Ala Val Val Val Cys Met Leu Ile Ile Ala Leu 5365 5370 5375 tgc atg gtg tac tat gcc ttc tgc tac aga aag cac aga ctg aac 32076 Cys Met Val Tyr Tyr Ala Phe Cys Tyr Arg Lys His Arg Leu Asn 5380 5385 5390 gac aag cta gaa cac tta cta agt gtt gaa ttt taattttttt agaacc 32125 Asp Lys Leu Glu His Leu Leu Ser Val Glu Phe 5395 5400 atg aag atc cta ggc ctt tta att ttt tct atc att acc tct gct 32170 Met Lys Ile Leu Gly Leu Leu Ile Phe Ser Ile Ile Thr Ser Ala 5405 5410 5415 cta tgc aat tct gac aat gag gac gtt act gtc gtt gtc gga tca 32215 Leu Cys Asn Ser Asp Asn Glu Asp Val Thr Val Val Val Gly Ser 5420 5425 5430 aat tat aca ctg aaa ggt cca gcg aag ggt atg ctt tcg tgg tat 32260 Asn Tyr Thr Leu Lys Gly Pro Ala Lys Gly Met Leu Ser Trp Tyr 5435 5440 5445 tgc tgg ttt gga act gac act gaa caa acc gaa tta tgc aat ctt 32305 Cys Trp Phe Gly Thr Asp Thr Glu Gln Thr Glu Leu Cys Asn Leu 5450 5455 5460 caa aat ggc aaa gtt cat aat tct aaa att tac aat tat ata tgc 32350 Gln Asn Gly Lys Val His Asn Ser Lys Ile Tyr Asn Tyr Ile Cys 5465 5470 5475 aat ggc act gat ttg ata ctc ctc aat atc acg aaa tca tat gct 32395 Asn Gly Thr Asp Leu Ile Leu Leu Asn Ile Thr Lys Ser Tyr Ala 5480 5485 5490 ggc agt tat tca tgc cct gga gat gat gct gac aat atg att ttt 32440 Gly Ser Tyr Ser Cys Pro Gly Asp Asp Ala Asp Asn Met Ile Phe 5495 5500 5505 tat aaa ttg caa gtg gtt gat ccc act act cca cct cca ccc acc 32485 Tyr Lys Leu Gln Val Val Asp Pro Thr Thr Pro Pro Pro Pro Thr 5510 5515 5520 aca act act cac acc aca cac aca gaa caa acc aca gca gag gag 32530 Thr Thr Thr His Thr Thr His Thr Glu Gln Thr Thr Ala Glu Glu 5525 5530 5535 gcg gca aag tta gct ttg cag gtc caa gac agt tca ttt gtt ggc 32575 Ala Ala Lys Leu Ala Leu Gln Val Gln Asp Ser Ser Phe Val Gly 5540 5545 5550 att acc cct aca ccc gat cag cgg tgt ccg ggg ctg ctc gtc agc 32620 Ile Thr Pro Thr Pro Asp Gln Arg Cys Pro Gly Leu Leu Val Ser 5555 5560 5565 ggc att gtc ggt gtg ctt tcg gga tta gca gtt ata atc atc tgc 32665 Gly Ile Val Gly Val Leu Ser Gly Leu Ala Val Ile Ile Ile Cys 5570 5575 5580 atg ttc att ttt gct tgc tgc tat aga agg ctt tac cga caa aaa 32710 Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr Arg Gln Lys 5585 5590 5595 tca gac cca ctg ctg aac ctc tat gtt taattttttc cagagcc atg aag 32760 Ser Asp Pro Leu Leu Asn Leu Tyr Val Met Lys 5600 5605 5610 gca gtt agc gct cta gtt ttt tgt tct ttg att ggc act gtt ttt 32805 Ala Val Ser Ala Leu Val Phe Cys Ser Leu Ile Gly Thr Val Phe 5615 5620 5625 agt gtt agc ttt tta aaa caa att aat gtt act gag ggg gaa aat 32850 Ser Val Ser Phe Leu Lys Gln Ile Asn Val Thr Glu Gly Glu Asn 5630 5635 5640 gtg aca ctg gta ggc gta gaa ggt gct caa aat acc acc tgg aca 32895 Val Thr Leu Val Gly Val Glu Gly Ala Gln Asn Thr Thr Trp Thr 5645 5650 5655 aaa tac cac ctc gat ggg tgg aaa gat att tgc aat tgg agt gtc 32940 Lys Tyr His Leu Asp Gly Trp Lys Asp Ile Cys Asn Trp Ser Val 5660 5665 5670 att act tac aca tgt gag gga gtt aat ttg acc ata gtc aat gcc 32985 Ile Thr Tyr Thr Cys Glu Gly Val Asn Leu Thr Ile Val Asn Ala 5675 5680 5685 agc caa aat cag aag ggt tgg att aaa ggg caa tct gtt agt gtt 33030 Ser Gln Asn Gln Lys Gly Trp Ile Lys Gly Gln Ser Val Ser Val 5690 5695 5700 acc agt gag ggg tac tat acc cag cat act ctt atc tat gac att 33075 Thr Ser Glu Gly Tyr Tyr Thr Gln His Thr Leu Ile Tyr Asp Ile 5705 5710 5715 ata gtc ata ccg ctg cct acg cct agc cca cct agc act acc aca 33120 Ile Val Ile Pro Leu Pro Thr Pro Ser Pro Pro Ser Thr Thr Thr 5720 5725 5730 cag aca acc cac act aca caa aca acc aca tac agt aca tca aat 33165 Gln Thr Thr His Thr Thr Gln Thr Thr Thr Tyr Ser Thr Ser Asn 5735 5740 5745 cag cct acc acc act aca aca gca gag gtt gcc agc tcg tct ggg 33210 Gln Pro Thr Thr Thr Thr Thr Ala Glu Val Ala Ser Ser Ser Gly 5750 5755 5760 gtc cga gcg gca ttt ttg atg ttg gcc cca tct agc agt ccc act 33255 Val Arg Ala Ala Phe Leu Met Leu Ala Pro Ser Ser Ser Pro Thr 5765 5770 5775 gct agt acc aat gag cag act act gaa ttt ttg tcc act gtc gag 33300 Ala Ser Thr Asn Glu Gln Thr Thr Glu Phe Leu Ser Thr Val Glu 5780 5785 5790 agc cac acc aca gct acc tcg agt gcc ttc tct agc acc gcc aat 33345 Ser His Thr Thr Ala Thr Ser Ser Ala Phe Ser Ser Thr Ala Asn 5795 5800 5805 ctc tcc tcg ctt tcc tct aca cca atc agt ccc gct act act act 33390 Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro Ala Thr Thr Thr 5810 5815 5820 acc ccc gct att ctt ccc act ccc ctg aag caa act gag gac agc 33435 Thr Pro Ala Ile Leu Pro Thr Pro Leu Lys Gln Thr Glu Asp Ser 5825 5830 5835 ggc atg caa tgg cag atc acc ctg ctc att gtg atc ggg ttg gtc 33480 Gly Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly Leu Val 5840 5845 5850 atc cta gcc gtg ttg ctc tac tac atc ttc cgc cgc cgc att ccc 33525 Ile Leu Ala Val Leu Leu Tyr Tyr Ile Phe Arg Arg Arg Ile Pro 5855 5860 5865 aac gcg cac cgc aag ccg gtc tac aag ccc atc att gtc ggg cag 33570 Asn Ala His Arg Lys Pro Val Tyr Lys Pro Ile Ile Val Gly Gln 5870 5875 5880 ccg gag ccg ctt cag gtg gaa ggg ggt cta agg aat ctt ctc ttc 33615 Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe 5885 5890 5895 tct ttt aca gta tgg tgattgaact atgattccta gacaattctt gatcactatt 33670 Ser Phe Thr Val Trp 5900 cttatctgcc tcctccaagt ctgtgccacc ctcgctctgg tggccaacgc cagtccagac 33730 tgtattgggc ccttcgcctc ctacgtgctc tttgccttca tcacctgcat ctgctgctgt 33790 agcatagtct gcctgcttat caccttcttc cagttcattg actggatctt tgtgcgcatc 33850 gcctacctgc gccaccaccc ccagtaccgc gaccagcgag tggcgcagct gctcaggctc 33910 ctctgataag c atg cgg gct ctg cta ctt ctc gcg ctt ctg ctg tta 33957 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu 5905 5910 gtg ctc ccc cgt ccc gtt gac ccc cgg ccc ccc act cag tcc ccc 34002 Val Leu Pro Arg Pro Val Asp Pro Arg Pro Pro Thr Gln Ser Pro 5915 5920 5925 gag gag gtc cgc aaa tgc aaa ttc caa gaa ccc tgg aaa ttc ctc 34047 Glu Glu Val Arg Lys Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu 5930 5935 5940 aaa tgc tac cgc caa aaa tca gac atg cat ccc agc tgg atc atg 34092 Lys Cys Tyr Arg Gln Lys Ser Asp Met His Pro Ser Trp Ile Met 5945 5950 5955 atc att ggg atc gtg aac att ctg gcc tgc acc ctc atc tcc ttt 34137 Ile Ile Gly Ile Val Asn Ile Leu Ala Cys Thr Leu Ile Ser Phe 5960 5965 5970 gtg att tac ccc tgc ttt gac ttt ggt tgg aac tcg cca gag gcg 34182 Val Ile Tyr Pro Cys Phe Asp Phe Gly Trp Asn Ser Pro Glu Ala 5975 5980 5985 ctc tat ctc ccg cct gaa cct gac aca cca cca cag caa cct cag 34227 Leu Tyr Leu Pro Pro Glu Pro Asp Thr Pro Pro Gln Gln Pro Gln 5990 5995 6000 gca cac gca cta cca cca cca cag cct agg cca caa tac atg ccc 34272 Ala His Ala Leu Pro Pro Pro Gln Pro Arg Pro Gln Tyr Met Pro 6005 6010 6015 ata tta gac tat gag gcc gag cca cag cga ccc atg ctc ccc gct 34317 Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg Pro Met Leu Pro Ala 6020 6025 6030 att agt tac ttc aat cta acc ggc gga gat gac tgacccactg 34360 Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 6035 6040 gccaacaaca acgtcaacga ccttctcctg gacatggacg gccgcgcctc ggagcagcga 34420 ctcgcccaac ttcgcattcg ccagcagcag gagagagccg tcaaggagct gcaggacggc 34480 atagccatcc accagtgcaa gaaaggcatc ttctgcctgg tgaaacaggc caagatctcc 34540 tacgaggtca cccagaccga ccatcgcctc tcctacgagc tcctgcagca gcgccagaag 34600 ttcacctgcc tggtcggagt caaccccatc gtcatcaccc agcagtcggg cgataccaag 34660 gggtgcatcc actgctcctg cgactccccc gactgcgtcc acactctgat caagaccctc 34720 tgcggcctcc gcgacctcct ccccatgaac taatcacccc cttatccagt gaaataaaga 34780 tcatattgat gattaaataa aaaaaataat catttgattt gaaataaaga tacaatcata 34840 ttgatgattt gagtttaata aaaataaaga atcacttact tgaaatctga taccaggtct 34900 ctgtccatgt tttctgccaa caccacttca ctcccctctt cccagctctg gtactgcagg 34960 ccccggcggg ctgcaaactt cctccacacc ctgaagggga tgtcaaattc ctcctgtccc 35020 tcaatcttca ttttatcttc tatcag atg tcc aaa aag cgc gtc cgg gtg 35070 Met Ser Lys Lys Arg Val Arg Val 6045 6050 gat gat gac ttc gac ccc gtc tac ccc tac gat gca gac aac gca 35115 Asp Asp Asp Phe Asp Pro Val Tyr Pro Tyr Asp Ala Asp Asn Ala 6055 6060 6065 ccg acc gtg ccc ttc atc aac ccc ccc ttc gtc tct tca gat gga 35160 Pro Thr Val Pro Phe Ile Asn Pro Pro Phe Val Ser Ser Asp Gly 6070 6075 6080 ttc caa gag aag ccc ctg ggg gtg ctg tcc ctg cgt ctg gcc gat 35205 Phe Gln Glu Lys Pro Leu Gly Val Leu Ser Leu Arg Leu Ala Asp 6085 6090 6095 ccc gtc acc acc aag aac ggg gaa atc acc ctc aag ctg gga gat 35250 Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu Lys Leu Gly Asp 6100 6105 6110 ggg gtg gac ctc gac tcc tcg gga aaa ctc atc tcc aac acg gcc 35295 Gly Val Asp Leu Asp Ser Ser Gly Lys Leu Ile Ser Asn Thr Ala 6115 6120 6125 acc aag gcc gcc gcc cct ctc agt ttt tcc aac aac acc att tcc 35340 Thr Lys Ala Ala Ala Pro Leu Ser Phe Ser Asn Asn Thr Ile Ser 6130 6135 6140 ctt aac atg gat acc cct ttt tac aac aac aat gga aag tta ggc 35385 Leu Asn Met Asp Thr Pro Phe Tyr Asn Asn Asn Gly Lys Leu Gly 6145 6150 6155 atg aaa gtc act gct cca ctg aag ata cta gac aca gac ttg cta 35430 Met Lys Val Thr Ala Pro Leu Lys Ile Leu Asp Thr Asp Leu Leu 6160 6165 6170 aaa aca ctt gtt gta gct tat gga caa ggt tta gga aca aac acc 35475 Lys Thr Leu Val Val Ala Tyr Gly Gln Gly Leu Gly Thr Asn Thr 6175 6180 6185 act ggt gcc ctt gtt gcc caa cta gca tcc cca ctt gct ttt gat 35520 Thr Gly Ala Leu Val Ala Gln Leu Ala Ser Pro Leu Ala Phe Asp 6190 6195 6200 agc aat agc aaa att gcc ctt aat tta ggc aat gga cca ttg aaa 35565 Ser Asn Ser Lys Ile Ala Leu Asn Leu Gly Asn Gly Pro Leu Lys 6205 6210 6215 gtg gat gca aat aga ctg aac atc aat tgc aat aga gga ctc tat 35610 Val Asp Ala Asn Arg Leu Asn Ile Asn Cys Asn Arg Gly Leu Tyr 6220 6225 6230 gtt act acc aca aaa gat gca ctg gaa gcc aat ata agt tgg gct 35655 Val Thr Thr Thr Lys Asp Ala Leu Glu Ala Asn Ile Ser Trp Ala 6235 6240 6245 aat gct atg aca ttt ata gga aat gcc atg ggt gtc aat att gat 35700 Asn Ala Met Thr Phe Ile Gly Asn Ala Met Gly Val Asn Ile Asp 6250 6255 6260 aca caa aaa ggc ttg caa ttt ggc acc act agt acc gtc gca gat 35745 Thr Gln Lys Gly Leu Gln Phe Gly Thr Thr Ser Thr Val Ala Asp 6265 6270 6275 gtt aaa aac gct tac ccc ata caa atc aaa ctt gga gct ggt ctc 35790 Val Lys Asn Ala Tyr Pro Ile Gln Ile Lys Leu Gly Ala Gly Leu 6280 6285 6290 aca ttt gac agc aca ggt gca att gtt gca tgg aac aaa gat gat 35835 Thr Phe Asp Ser Thr Gly Ala Ile Val Ala Trp Asn Lys Asp Asp 6295 6300 6305 gac aag ctt aca cta tgg acc aca gcc gac ccc tct cca aat tgt 35880 Asp Lys Leu Thr Leu Trp Thr Thr Ala Asp Pro Ser Pro Asn Cys 6310 6315 6320 cac ata tat tct gaa aag gat gct aag ctt aca ctt tgc ttg aca 35925 His Ile Tyr Ser Glu Lys Asp Ala Lys Leu Thr Leu Cys Leu Thr 6325 6330 6335 aag tgt ggc agt cag att ctg ggc act gtt tcc ctc ata gct gtt 35970 Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Ser Leu Ile Ala Val 6340 6345 6350 gat act ggc agt tta aat ccc ata aca gga aca gta acc act gct 36015 Asp Thr Gly Ser Leu Asn Pro Ile Thr Gly Thr Val Thr Thr Ala 6355 6360 6365 ctt gtc tca ctt aaa ttc gat gca aat gga gtt ttg caa agc agc 36060 Leu Val Ser Leu Lys Phe Asp Ala Asn Gly Val Leu Gln Ser Ser 6370 6375 6380 tca aca cta gac tca gac tat tgg aat ttc aga cag gga gat gtt 36105 Ser Thr Leu Asp Ser Asp Tyr Trp Asn Phe Arg Gln Gly Asp Val 6385 6390 6395 aca cct gct gaa gcc tat act aat gct ata ggt ttc atg ccc aat 36150 Thr Pro Ala Glu Ala Tyr Thr Asn Ala Ile Gly Phe Met Pro Asn 6400 6405 6410 cta aaa gca tac cct aaa aac aca agt gga gct gca aaa agt cac 36195 Leu Lys Ala Tyr Pro Lys Asn Thr Ser Gly Ala Ala Lys Ser His 6415 6420 6425 att gtt ggg aaa gtg tac cta cat ggg gat aca gac aaa cca ctg 36240 Ile Val Gly Lys Val Tyr Leu His Gly Asp Thr Asp Lys Pro Leu 6430 6435 6440 gac ctc att att act ttc aat gaa aca agt gat gaa tct tgc act 36285 Asp Leu Ile Ile Thr Phe Asn Glu Thr Ser Asp Glu Ser Cys Thr 6445 6450 6455 tac tgt att aac ttt caa tgg cag tgg ggg gct gat caa tat aaa 36330 Tyr Cys Ile Asn Phe Gln Trp Gln Trp Gly Ala Asp Gln Tyr Lys 6460 6465 6470 aat gaa aca ctt gcc gtc agt tca ttc acc ttt tcc tat att gct 36375 Asn Glu Thr Leu Ala Val Ser Ser Phe Thr Phe Ser Tyr Ile Ala 6475 6480 6485 aaa gaa taaaccccac tctgtacccc atctctgtct atggaaaaaa ctctgaaaca 36431 Lys Glu caaaataaaa taaagttcaa gtgttttatt gattcaacag ttttacagga ttcgagcagt 36491 tatttttcct ccaccctccc aggacatgga atacaccacc ctctcccccc gcacagcctt 36551 gaacatctga atgccattgg tgatggacat gcttttggtc tccacgttcc acacagtttc 36611 agagcgagcc agtctcgggt cggtcaggga gatgaaaccc tccgggcact cccgcatctg 36671 cacctcacag ctcaacagct gaggattgtc ctcggtggtc gggatcacgg ttatctggaa 36731 gaagcagaag agcggcggtg ggaatcatag tccgcgaacg ggatcggccg gtggtgtcgc 36791 atcaggcccc gcagcagtcg ctgtcgccgc cgctccgtca agctgctgct cagggggtcc 36851 gggtccaggg actccctcag catgatgccc acggccctca gcatcagtcg tctggtgcgg 36911 cgggcgcagc agcgcatgcg gatctcgctc aggtcgctgc agtacgtgca acacaggacc 36971 accaggttgt tcaacagtcc atagttcaac acgctccagc cgaaactcat cgcgggaagg 37031 atgctaccca cgtggccgtc gtaccagatc ctcaggtaaa tcaagtggcg ccccctccag 37091 aacacgctgc ccatgtacat gatctccttg ggcatgtggc ggttcaccac ctcccggtac 37151 cacatcaccc tctggttgaa catgcagccc cggatgatcc tgcggaacca cagggccagc 37211 accgccccgc ccgccatgca gcgaagagac cccgggtccc gacaatggca atggaggacc 37271 caccgctcgt acccgtggat catctgggag ctgaacaagt ctatgttggc acagcacagg 37331 catatgctca tgcatctctt cagcactctc agctcctcgg gggtcaaaac catatcccag 37391 ggcacgggga actcttgcag gacagcgaac cccgcagaac agggcaatcc tcgcacataa 37451 cttacattgt gcatggacag ggtatcgcaa tcaggcagca ccgggtgatc ctccaccaga 37511 gaagcgcggg tctcggtctc ctcacagcgt ggtaaggggg ccggccgata cgggtgatgg 37571 cgggacgcgg ctgatcgtgt tcgcgaccgt gtcatgatgc agttgctttc ggacattttc 37631 gtacttgctg tagcagaacc tggtccgggc gctgcacacc gatcgccggc ggcggtcccg 37691 gcgcttggaa cgctcggtgt tgaagttgta aaacagccac tctctcagac cgtgcagcag 37751 atctagggcc tcaggagtga tgaagatccc atcatgcctg atggctctaa tcacatcgac 37811 caccgtggaa tgggccagac ccagccagat gatgcaattt tgttgggttt cggtgacggc 37871 gggggaggga agaacaggaa gaaccatgat taacttttaa tccaaacggt ctcggagcac 37931 ttcaaaatga agatcgcgga gatggcacct ctcgcccccg ctgtgttggt ggaaaataac 37991 agccaggtca aaggtgatac ggttctcgag atgttccacg gtggcttcca gcaaagcctc 38051 cacgcgcaca tccagaaaca agacaatagc gaaagcggga gggttctcta attcctcaat 38111 catcatgtta cactcctgca ccatccccag ataattttca tttttccagc cttgaatgat 38171 tcgaactagt tcctgaggta aatccaagcc agccatgata aagagctcgc gcagagcgcc 38231 ctccaccggc attcttaagc acaccctcat aattccaaga tattctgctc ctggttcacc 38291 tgcagcagat tgacaagcgg aatatcaaaa tctctgccgc gatccctaag ctcctccctc 38351 agcaataact gtaagtactc tttcatatcc tctccgaaat ttttagccat aggaccgcca 38411 ggaatgagat taggacaagc cacattacag ataaaccgaa gtccccccca gtgagcattg 38471 ccaaatgtaa gattgaaata agcatgctgg ctagacccgg tgatatcttc cagataactg 38531 gacagaaaat cgcccaggca atttttaaga aaatcaacaa aagaaaaatc ttccaggtgc 38591 acgtttaggg cctcgggaac aacgatggag taagtgcaag gggtgcgttc cagcatggtt 38651 agttagctga tctgtaaaaa aacaaaaaat aaaacattaa accatg 38697 <210> 128 <211> 363 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 128 Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 1 5 10 15 Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 20 25 30 His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 35 40 45 Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 50 55 60 Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 65 70 75 80 Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 85 90 95 Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 100 105 110 Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val 115 120 125 Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 130 135 140 Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 145 150 155 160 Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 165 170 175 Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 180 185 190 Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 195 200 205 Ala Ala Asp Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 210 215 220 Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 225 230 235 240 Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 245 250 255 Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 260 265 270 Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 275 280 285 Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 290 295 300 Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 305 310 315 320 Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 325 330 335 Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 340 345 350 Val Gly Gly Pro Gly His Lys Ala Arg Val Leu 355 360 <210> 129 <211> 391 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 129 Met His Pro Val Leu Arg Gln Met Arg Pro His Pro Pro Pro Gln Pro 1 5 10 15 Pro Leu Pro Pro Gln Gln Gln Gln Gln Pro Ala Leu Leu Pro Pro Pro 20 25 30 Gln Gln Gln Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala Gly 35 40 45 Val Gln Tyr Asp Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala Arg Leu 50 55 60 Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys Arg Asp 65 70 75 80 Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp Arg Ser 85 90 95 Gly Glu Glu Pro Glu Glu Met Arg Ala Ser Arg Phe His Ala Gly Arg 100 105 110 Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp Glu Asp 115 120 125 Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala His Val 130 135 140 Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys Glu Glu 145 150 155 160 Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu Ile Ala 165 170 175 Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu Leu Glu 180 185 190 Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln Leu Phe 195 200 205 Leu Val Val Gln His Ser Arg Asp Asn Glu Thr Phe Arg Glu Ala Leu 210 215 220 Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu Val Asn 225 230 235 240 Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu Ser Glu 245 250 255 Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys Tyr Tyr 260 265 270 Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys Glu Val 275 280 285 Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu Thr Leu 290 295 300 Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg Ala Val 305 310 315 320 Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met His Ser 325 330 335 Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser Tyr Phe 340 345 350 Asp Met Gly Ala Asp Leu Arg Trp Gln Pro Ser Arg Arg Ala Leu Glu 355 360 365 Ala Ala Gly Gly Val Pro Tyr Val Glu Glu Val Asp Asp Asp Glu Glu 370 375 380 Glu Gly Glu Tyr Leu Glu Asp 385 390 <210> 130 <211> 587 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 130 Met Gln Gln Gln Pro Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu 1 5 10 15 Gln Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala 20 25 30 Met Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg 35 40 45 Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val 50 55 60 Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn 65 70 75 80 Ala Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val 85 90 95 Tyr Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val 100 105 110 Gln Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ser 115 120 125 Gln Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala 130 135 140 Leu Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln 145 150 155 160 Glu Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Ala Glu 165 170 175 Val Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln 180 185 190 Thr Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys 195 200 205 Asn Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala 210 215 220 Thr Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu 225 230 235 240 Val Ala Pro Phe Thr Asp Ser Gly Ser Val Ser Arg Asp Ser Tyr Leu 245 250 255 Gly Tyr Leu Leu Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val 260 265 270 Asp Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly 275 280 285 Gln Glu Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr 290 295 300 Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu 305 310 315 320 Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met 325 330 335 Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn 340 345 350 Met Glu Pro Ser Met Tyr Ala Arg Asn Arg Pro Phe Ile Asn Lys Leu 355 360 365 Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr 370 375 380 Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr 385 390 395 400 Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp 405 410 415 Val Asp Ser Ser Val Phe Ser Pro Arg Pro Thr Thr Thr Val Trp Lys 420 425 430 Lys Glu Gly Gly Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly Arg Ala 435 440 445 Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu 450 455 460 Pro Phe Ser Leu Asn Ser Val Arg Ser Ser Glu Leu Gly Arg Leu Thr 465 470 475 480 Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu 485 490 495 Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu 500 505 510 Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala His Glu His Arg Asp 515 520 525 Glu Pro Arg Ala Ser Ser Ser Ala Gly Ala Thr Arg Arg Arg Gln Arg 530 535 540 His Asp Arg Gln Arg Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp 545 550 555 560 Asp Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe 565 570 575 Ala His Leu Arg Pro Arg Ile Gly Arg Leu Met 580 585 <210> 131 <211> 542 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 131 Met Met Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Val Ala Ala Ala Met Gln Pro Pro Leu Glu Ala 20 25 30 Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg Asn Ser 35 40 45 Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg Leu Tyr 50 55 60 Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr Gln Asn 65 70 75 80 Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp Phe Thr 85 90 95 Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg 100 105 110 Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro Asn Val 115 120 125 Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser 130 135 140 Arg Lys Thr Pro Asn Gly Val Thr Val Asp Glu Asn Tyr Asp Gly Ser 145 150 155 160 Gln Asp Glu Leu Thr Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly 165 170 175 Asn Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile 180 185 190 Asp Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp 195 200 205 Ile Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro 210 215 220 Val Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His 225 230 235 240 Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser 245 250 255 Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu 260 265 270 Gly Phe Gln Ile Leu Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala 275 280 285 Leu Leu Asp Val Glu Ala Tyr Glu Lys Ser Lys Glu Glu Ala Ala Ala 290 295 300 Ala Ala Thr Ala Ala Val Ala Thr Ala Ala Thr Thr Asp Ala Asp Ala 305 310 315 320 Ala Thr Thr Thr Arg Gly Asp Thr Phe Ala Thr Gln Ala Glu Glu Ala 325 330 335 Ala Ala Leu Ala Ala Thr Asp Asp Ser Glu Ser Lys Ile Val Ile Lys 340 345 350 Pro Val Glu Lys Asp Ser Lys Asp Arg Ser Tyr Asn Val Leu Ser Asp 355 360 365 Gly Lys Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly 370 375 380 Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp 385 390 395 400 Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met 405 410 415 Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn Tyr Pro 420 425 430 Val Val Gly Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser Phe Phe Asn 435 440 445 Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Ala Phe Thr Ser Leu Thr 450 455 460 His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Val Arg Pro Pro 465 470 475 480 Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp 485 490 495 His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val 500 505 510 Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala 515 520 525 Leu Gly Val Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 530 535 540 <210> 132 <211> 194 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 132 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Ala Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ser 130 135 140 Ser Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala 145 150 155 160 Ala Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val 165 170 175 Arg Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro 180 185 190 Arg Thr <210> 133 <211> 348 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 133 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys Glu Glu Arg Lys Pro Arg 20 25 30 Lys Leu Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Glu Asp Asp Gly 35 40 45 Leu Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp 50 55 60 Arg Gly Arg Lys Val Lys Pro Val Leu Arg Pro Gly Thr Thr Val Val 65 70 75 80 Phe Thr Pro Gly Glu Arg Ser Gly Ser Ala Ser Lys Arg Ser Tyr Asp 85 90 95 Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu 100 105 110 Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Pro Ala Pro Leu Lys Glu 115 120 125 Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu 130 135 140 Lys Pro Val Thr Leu Gln Gln Val Leu Pro Ser Ala Ala Pro Arg Arg 145 150 155 160 Gly Phe Lys Arg Glu Gly Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu 165 170 175 Met Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu His Met Lys 180 185 190 Val Asp Pro Glu Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln 195 200 205 Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr 210 215 220 Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr 225 230 235 240 Met Glu Val Gln Thr Asp Pro Trp Met Pro Ala Pro Ala Ser Thr Thr 245 250 255 Thr Thr Thr Arg Arg Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met 260 265 270 Pro Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg 275 280 285 Gly Thr Arg Phe Tyr Arg Gly Tyr Ser Ser Arg Arg Lys Thr Thr Thr 290 295 300 Arg Arg Arg Arg Arg Arg Thr Arg Arg Ser Thr Thr Ala Thr Ser Ala 305 310 315 320 Ala Ala Leu Val Arg Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu Thr 325 330 335 Leu Pro Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 340 345 <210> 134 <211> 77 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 134 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly Asn Gly Leu Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 135 <211> 244 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 135 Met Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg 1 5 10 15 Pro Phe Met Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly 20 25 30 Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly 35 40 45 Ser Thr Leu Lys Thr Tyr Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly 50 55 60 Gln Ala Leu Arg Asp Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val 65 70 75 80 Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn 85 90 95 Gln Ala Val Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro 100 105 110 Ala Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu 115 120 125 Asp Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu 130 135 140 Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu 145 150 155 160 Gly Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu 165 170 175 Lys Pro Glu Ser Asn Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Gln 180 185 190 Pro Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val 195 200 205 Ala Arg Ala Arg Pro Gly Gly Ser Ala Arg Pro His Ala Asn Trp Gln 210 215 220 Ser Thr Leu Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg 225 230 235 240 Arg Arg Cys Tyr <210> 136 <211> 943 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 136 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Ser Ser Gln Trp Glu Arg Ala Lys Thr Asn Asn Asn Gly 130 135 140 Ala Thr Glu Ser Val Thr Phe Gly Val Ala Ala Met Gly Gly Ile Asp 145 150 155 160 Ile Thr Lys Glu Gly Leu Gln Ile Gly Thr Asp Glu Thr Lys Ala Asp 165 170 175 Ser Lys Glu Ile Tyr Ala Asp Lys Thr Tyr Gln Pro Glu Pro Gln Ile 180 185 190 Gly Glu Glu Asn Trp Gln Glu Thr Phe Ser Tyr Tyr Gly Gly Arg Ala 195 200 205 Leu Lys Lys Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys 210 215 220 Pro Thr Asn Val Lys Gly Gly Gln Ala Lys Phe Lys Val Gln Asp Gly 225 230 235 240 Gln Gln Thr Thr Glu Tyr Asp Ile Asp Leu Ala Phe Phe Asp Ile Pro 245 250 255 Asn Ser Gly Thr Gly Gly Asn Gly Thr Asn Val Asn Tyr Asp Pro Asp 260 265 270 Met Val Met Tyr Thr Glu Asn Val Asp Leu Glu Thr Pro Asp Thr His 275 280 285 Ile Val Tyr Lys Pro Gly Thr Ser Asp Asp Ser Ser Glu Ala Asn Leu 290 295 300 Leu Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp 305 310 315 320 Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val 325 330 335 Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp 340 345 350 Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp 355 360 365 Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp 370 375 380 Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro 385 390 395 400 Asn Tyr Cys Phe Pro Leu Asp Gly Ala Gly Thr Asn Ala Val Tyr Gln 405 410 415 Gly Val Lys Ala Lys Thr Asn Gly Gly Ala Ala Asn Gly Asp Trp Glu 420 425 430 Gln Asp Thr Asp Val Ser Asn Ile Asn Gln Ile Cys Lys Gly Asn Ile 435 440 445 Tyr Ala Met Glu Ile Asn Leu Gln Ala Asn Leu Trp Arg Ser Phe Leu 450 455 460 Tyr Ser Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr Pro 465 470 475 480 Ala Asn Ile Thr Leu Pro Thr Asn Thr Asn Thr Tyr Asp Tyr Met Asn 485 490 495 Gly Arg Val Ala Pro Pro Ser Leu Val Asp Ala Tyr Ile Asn Ile Gly 500 505 510 Ala Arg Trp Ser Leu Asp Pro Met Asp Asn Val Asn Pro Phe Asn His 515 520 525 His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly 530 535 540 Arg Phe Val Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile 545 550 555 560 Lys Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe 565 570 575 Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu 580 585 590 Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala 595 600 605 Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met 610 615 620 Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala 625 630 635 640 Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Val Pro Ile 645 650 655 Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr 660 665 670 Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro 675 680 685 Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr 690 695 700 Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe Asp Ser Ser Val 705 710 715 720 Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile 725 730 735 Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met 740 745 750 Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly 755 760 765 Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser 770 775 780 Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Val 785 790 795 800 Asn Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn Asn 805 810 815 Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln Pro 820 825 830 Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val Thr 835 840 845 Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met Trp Arg Ile 850 855 860 Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly 865 870 875 880 Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Asn Phe 885 890 895 Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr Val Val Phe Glu 900 905 910 Val Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu 915 920 925 Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 930 935 940 <210> 137 <211> 208 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 137 Met Ala Glu Pro Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile 1 5 10 15 Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg 20 25 30 Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn 35 40 45 Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp 50 55 60 Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser 65 70 75 80 Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu Leu 85 90 95 Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu Lys 100 105 110 Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu Phe 115 120 125 Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro Met 130 135 140 Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly Met 145 150 155 160 Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu Ala 165 170 175 Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe Arg Ser His Arg 180 185 190 Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Gln Asp Met 195 200 205 <210> 138 <211> 798 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 138 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ala 1 5 10 15 Ala Asp Glu Asn Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro 20 25 30 Pro Ser Pro Thr Ser Asp Ala Ala Ala Pro Asp Met Gln Glu Met Glu 35 40 45 Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu 50 55 60 Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln Glu 65 70 75 80 Gln Pro Glu Gln Glu Ala Glu Ser Glu Gln Ser Gln Ala Gly Leu Glu 85 90 95 His Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu Ile Lys His Leu 100 105 110 Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Ala Glu 115 120 125 Val Pro Leu Ser Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg Asn Leu 130 135 140 Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys Glu 145 150 155 160 Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu Ala 165 170 175 Leu Ala Thr Tyr His Leu Phe Phe Lys Asn Gln Arg Ile Pro Val Ser 180 185 190 Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Leu Asn Leu Gly Pro 195 200 205 Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro Lys Ile 210 215 220 Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu Gln 225 230 235 240 Gly Ser Gly Glu Glu His Glu His His Ser Ala Leu Val Glu Leu Glu 245 250 255 Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu Thr 260 265 270 His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser Ala 275 280 285 Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu Glu 290 295 300 Glu Met Gln Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val Val Ser 305 310 315 320 Asp Glu Gln Leu Ala Arg Trp Leu Gly Thr Ser Ser Thr Pro Gln Ser 325 330 335 Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr Val 340 345 350 Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu Arg 355 360 365 Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val Arg 370 375 380 Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr 385 390 395 400 Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr 405 410 415 Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr 420 425 430 Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln Gln 435 440 445 Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys 450 455 460 Asn Leu Lys Ala Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser 465 470 475 480 Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg 485 490 495 Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg 500 505 510 Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala 515 520 525 Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro 530 535 540 Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala Tyr 545 550 555 560 His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu Cys 565 570 575 His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys Asn 580 585 590 Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln 595 600 605 Gly Pro Gly Glu Glu Gly Lys Gly Gly Leu Lys Leu Thr Pro Gly Leu 610 615 620 Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr His Pro 625 630 635 640 Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys Ala Glu 645 650 655 Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala Gln Leu Gln 660 665 670 Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly His Gly 675 680 685 Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro Ser Phe Pro 690 695 700 Gln Asp Ala Gln Arg Lys Gln Gln Glu Ala Glu Ser Gly Ala Ala Ala 705 710 715 720 Ala Ala Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly 725 730 735 Gly Gly Asp Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln Pro 740 745 750 Ala Arg Gln Ser Gly Arg Arg Gly Gly Gly Gly Arg Gly Arg Ser Ser 755 760 765 Arg Arg Gln Thr Val Val Leu Gly Gly Glu Ser Lys Gln His Gly Tyr 770 775 780 His Leu Arg Ser Gly Ser Gly Ser Arg Arg Pro Gly Pro Gln 785 790 795 <210> 139 <211> 227 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 139 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr 50 55 60 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 140 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 140 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Ala 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Ile Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Arg Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asn His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 141 <211> 176 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 141 Met Gly Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val Val 1 5 10 15 Leu Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu Lys Ala 20 25 30 Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Thr Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Ala His Met Cys Asp Thr Val Met Trp Met Ser Lys Gln Tyr Asp Met 115 120 125 Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Leu Cys Thr Val Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 142 <211> 200 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 142 Met Ala Ser Val Lys Phe Leu Leu Leu Phe Ala Ser Leu Ile Thr Val 1 5 10 15 Ile Ser Asn Glu Lys Leu Thr Ile Tyr Ile Gly Thr Asn His Thr Leu 20 25 30 Glu Gly Ile Pro Lys Ser Ser Trp Tyr Cys Tyr Phe Asp Gln Asp Pro 35 40 45 Asp Leu Thr Ile Glu Leu Cys Gly Asn Lys Gly Gln Asn Thr Ser Ile 50 55 60 His Leu Ile Asn Phe Lys Cys Gly Asp Asp Leu Lys Leu Ile Asn Ile 65 70 75 80 Thr Lys Glu Tyr Gly Gly Met Tyr Tyr Tyr Val Thr Glu Asn Asn Asn 85 90 95 Met Gln Phe Tyr Glu Val Thr Val Thr Asn Pro Thr Thr Pro Arg Thr 100 105 110 Thr Thr Thr Thr Thr Lys Thr Thr Pro Val Thr Thr Met Gln Leu Thr 115 120 125 Thr Asn Asn Ile Phe Ala Met Arg Gln Lys Ala Asn Asn Ser Thr Ser 130 135 140 Ile Gln Pro Pro Pro Pro Ser Glu Glu Ile Pro Lys Ser Met Ile Gly 145 150 155 160 Ile Ile Val Ala Val Val Val Cys Met Leu Ile Ile Ala Leu Cys Met 165 170 175 Val Tyr Tyr Ala Phe Cys Tyr Arg Lys His Arg Leu Asn Asp Lys Leu 180 185 190 Glu His Leu Leu Ser Val Glu Phe 195 200 <210> 143 <211> 204 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 143 Met Lys Ile Leu Gly Leu Leu Ile Phe Ser Ile Ile Thr Ser Ala Leu 1 5 10 15 Cys Asn Ser Asp Asn Glu Asp Val Thr Val Val Val Gly Ser Asn Tyr 20 25 30 Thr Leu Lys Gly Pro Ala Lys Gly Met Leu Ser Trp Tyr Cys Trp Phe 35 40 45 Gly Thr Asp Thr Glu Gln Thr Glu Leu Cys Asn Leu Gln Asn Gly Lys 50 55 60 Val His Asn Ser Lys Ile Tyr Asn Tyr Ile Cys Asn Gly Thr Asp Leu 65 70 75 80 Ile Leu Leu Asn Ile Thr Lys Ser Tyr Ala Gly Ser Tyr Ser Cys Pro 85 90 95 Gly Asp Asp Ala Asp Asn Met Ile Phe Tyr Lys Leu Gln Val Val Asp 100 105 110 Pro Thr Thr Pro Pro Pro Pro Thr Thr Thr Thr His Thr Thr His Thr 115 120 125 Glu Gln Thr Thr Ala Glu Glu Ala Ala Lys Leu Ala Leu Gln Val Gln 130 135 140 Asp Ser Ser Phe Val Gly Ile Thr Pro Thr Pro Asp Gln Arg Cys Pro 145 150 155 160 Gly Leu Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly Leu Ala Val 165 170 175 Ile Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr 180 185 190 Arg Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 195 200 <210> 144 <211> 292 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 144 Met Lys Ala Val Ser Ala Leu Val Phe Cys Ser Leu Ile Gly Thr Val 1 5 10 15 Phe Ser Val Ser Phe Leu Lys Gln Ile Asn Val Thr Glu Gly Glu Asn 20 25 30 Val Thr Leu Val Gly Val Glu Gly Ala Gln Asn Thr Thr Trp Thr Lys 35 40 45 Tyr His Leu Asp Gly Trp Lys Asp Ile Cys Asn Trp Ser Val Ile Thr 50 55 60 Tyr Thr Cys Glu Gly Val Asn Leu Thr Ile Val Asn Ala Ser Gln Asn 65 70 75 80 Gln Lys Gly Trp Ile Lys Gly Gln Ser Val Ser Val Thr Ser Glu Gly 85 90 95 Tyr Tyr Thr Gln His Thr Leu Ile Tyr Asp Ile Ile Val Ile Pro Leu 100 105 110 Pro Thr Pro Ser Pro Pro Ser Thr Thr Thr Gln Thr Thr His Thr Thr 115 120 125 Gln Thr Thr Thr Tyr Ser Thr Ser Asn Gln Pro Thr Thr Thr Thr Thr 130 135 140 Ala Glu Val Ala Ser Ser Ser Gly Val Arg Ala Ala Phe Leu Met Leu 145 150 155 160 Ala Pro Ser Ser Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Glu 165 170 175 Phe Leu Ser Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe 180 185 190 Ser Ser Thr Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro 195 200 205 Ala Thr Thr Thr Thr Pro Ala Ile Leu Pro Thr Pro Leu Lys Gln Thr 210 215 220 Glu Asp Ser Gly Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly 225 230 235 240 Leu Val Ile Leu Ala Val Leu Leu Tyr Tyr Ile Phe Arg Arg Arg Ile 245 250 255 Pro Asn Ala His Arg Lys Pro Val Tyr Lys Pro Ile Ile Val Gly Gln 260 265 270 Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser 275 280 285 Phe Thr Val Trp 290 <210> 145 <211> 143 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 145 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu Val Leu Pro Arg 1 5 10 15 Pro Val Asp Pro Arg Pro Pro Thr Gln Ser Pro Glu Glu Val Arg Lys 20 25 30 Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys 35 40 45 Ser Asp Met His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile 50 55 60 Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Cys Phe Asp Phe 65 70 75 80 Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr 85 90 95 Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Pro Gln Pro Arg 100 105 110 Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg Pro 115 120 125 Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 130 135 140 <210> 146 <211> 445 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 146 Met Ser Lys Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro Val Tyr 1 5 10 15 Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro 20 25 30 Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser 35 40 45 Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu 50 55 60 Lys Leu Gly Asp Gly Val Asp Leu Asp Ser Ser Gly Lys Leu Ile Ser 65 70 75 80 Asn Thr Ala Thr Lys Ala Ala Ala Pro Leu Ser Phe Ser Asn Asn Thr 85 90 95 Ile Ser Leu Asn Met Asp Thr Pro Phe Tyr Asn Asn Asn Gly Lys Leu 100 105 110 Gly Met Lys Val Thr Ala Pro Leu Lys Ile Leu Asp Thr Asp Leu Leu 115 120 125 Lys Thr Leu Val Val Ala Tyr Gly Gln Gly Leu Gly Thr Asn Thr Thr 130 135 140 Gly Ala Leu Val Ala Gln Leu Ala Ser Pro Leu Ala Phe Asp Ser Asn 145 150 155 160 Ser Lys Ile Ala Leu Asn Leu Gly Asn Gly Pro Leu Lys Val Asp Ala 165 170 175 Asn Arg Leu Asn Ile Asn Cys Asn Arg Gly Leu Tyr Val Thr Thr Thr 180 185 190 Lys Asp Ala Leu Glu Ala Asn Ile Ser Trp Ala Asn Ala Met Thr Phe 195 200 205 Ile Gly Asn Ala Met Gly Val Asn Ile Asp Thr Gln Lys Gly Leu Gln 210 215 220 Phe Gly Thr Thr Ser Thr Val Ala Asp Val Lys Asn Ala Tyr Pro Ile 225 230 235 240 Gln Ile Lys Leu Gly Ala Gly Leu Thr Phe Asp Ser Thr Gly Ala Ile 245 250 255 Val Ala Trp Asn Lys Asp Asp Asp Lys Leu Thr Leu Trp Thr Thr Ala 260 265 270 Asp Pro Ser Pro Asn Cys His Ile Tyr Ser Glu Lys Asp Ala Lys Leu 275 280 285 Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Ser 290 295 300 Leu Ile Ala Val Asp Thr Gly Ser Leu Asn Pro Ile Thr Gly Thr Val 305 310 315 320 Thr Thr Ala Leu Val Ser Leu Lys Phe Asp Ala Asn Gly Val Leu Gln 325 330 335 Ser Ser Ser Thr Leu Asp Ser Asp Tyr Trp Asn Phe Arg Gln Gly Asp 340 345 350 Val Thr Pro Ala Glu Ala Tyr Thr Asn Ala Ile Gly Phe Met Pro Asn 355 360 365 Leu Lys Ala Tyr Pro Lys Asn Thr Ser Gly Ala Ala Lys Ser His Ile 370 375 380 Val Gly Lys Val Tyr Leu His Gly Asp Thr Asp Lys Pro Leu Asp Leu 385 390 395 400 Ile Ile Thr Phe Asn Glu Thr Ser Asp Glu Ser Cys Thr Tyr Cys Ile 405 410 415 Asn Phe Gln Trp Gln Trp Gly Ala Asp Gln Tyr Lys Asn Glu Thr Leu 420 425 430 Ala Val Ser Ser Phe Thr Phe Ser Tyr Ile Ala Lys Glu 435 440 445 <210> 147 <211> 34800 <212> DNA <213> Artificial Sequence <220> <223> Simian adenovirus A1320 clone <220> <221> CDS <222> (28484)..(29038) <223> 22K <220> <221> CDS <222> (30345)..(30965) <223> E3\CR1-alpha <220> <221> CDS <222> (34346)..(34750) <223> E3\14.7K <400> 147 ctagcctggc gaacaggtgg gtaaatcgtt ctctccagca ccaggcaggc cacggggtct 60 ccggcgcgac cctcgtaaaa attgtcgcta tgattgaaaa ccatcacaga gagacgttcc 120 cggtggccgg cgtgaatgat tcgacaagat gaatacaccc ccggaacatt ggcgtccgcg 180 agtgaaaaaa agcggccgag gaagcaataa ggcactacaa tgctcagtct caagtccagc 240 aaagcgatgc catgcggatg aagcacaaaa ttctcaggtg cgtacaaaat gtaattactc 300 ccctcctgca caggcagcaa agccccagat ccctccagat acacatacaa agcctcagcg 360 tccatagctt accgagcagc agcacacaac aggcgcaaga gtcagagaaa ggctgagctc 420 taacctgtcc cccgctctct gctcaatata tagcccagat ctacactgac gtaaaggcca 480 aagtctaaaa atacccgcca aataatcaca cacgcccagc acacgcccag aaaccggtga 540 cacactcaaa aaaatacgcg cacttcctca aacgcccaaa ctgccgtcat ttccgggttc 600 ccacgctacg tcatcagaat tcgactttca aatccgtcga ccgttaaaca cgtcactcgc 660 cccgccccta acggtcgccc tcctctcggc caatcacagc cccgcatccc caaattcaaa 720 cgcctcattt gcatattaac gcgcacaaaa agtttgaggt atattattga tgatgatcgt 780 ttaaactatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg 840 ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt 900 atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa 960 gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc 1020 gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag 1080 gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt 1140 gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg 1200 aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg 1260 ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg 1320 taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac 1380 tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg 1440 gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt 1500 taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg 1560 tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc 1620 tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt 1680 ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt 1740 taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag 1800 tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt 1860 cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg caatgatacc 1920 gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc 1980 cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg 2040 ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctgc 2100 aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg 2160 atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc 2220 tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact 2280 gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc 2340 aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaac 2400 acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc 2460 ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac 2520 tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa 2580 aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact 2640 catactcttc ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg 2700 atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg 2760 aaaagtgcca cctgacgtct aagaaaccat tattatcatg acattaacct ataaaaatag 2820 gcgtatcacg aggccctttc gtcttcaaga attgtttaaa ctaccatcat caataatata 2880 cctcaaactt tttgtgcgcg ttaatatgca aatgaggcgt ttgaatttgg ggatgcgggg 2940 cggtgattgg ctgtgggaaa ggcgaccgtt aggggcgggg cgggtgacgt tttgatgacg 3000 tgtttgtgag gcggagccgg tttgcaagtt ctcgtgggaa aagtgacgtc aaacgaggtg 3060 tggtttgaac acggaaatac tcaattttcc cgcgctctct gacaggaaat gaggtgtttc 3120 tgggcggatg caagtgaaaa cgggccattt tcgcgcgaaa actgaatgag gaagtgaaaa 3180 tctgagtaat ttcgcgttta tggcagggag gagtatttgc cgagggccga gtagactttg 3240 accgattacg tgggggtttc gattaccgtg tttttcacct aaatttccgc gtacggtgtc 3300 aaagtccggt gtttttacat catttccccg aaaagtgcca cctgacgtaa ctataacggt 3360 cctaaggtag cgaaagctca gatctggatc tcccgatccc ctatggcgac tctcagtaca 3420 atctgctctg atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc 3480 gctgagtagt gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc 3540 atgaagaatc tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat 3600 acgcgttgac attgattatt gactagttat taatagtaat caattacggg gtcattagtt 3660 catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga 3720 ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca 3780 atagggactt tccattgacg tcaatgggtg gactatttac ggtaaactgc ccacttggca 3840 gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg 3900 cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc 3960 tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt 4020 ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt 4080 ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg 4140 acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc tcgtttagtg 4200 aaccgtcaga tcgcctggag acgccatcca cgctgttttg acctccatag aagacaccgg 4260 gaccgatcca gcctccgcgg gcgcgcgtcg acagagagat gggtgcgaga gcgtcagtat 4320 taagcggggg agaattagat cgatgggaaa aaattcggtt aaggccaggg ggaaagaaga 4380 agtacaagct aaagcacatc gtatgggcaa gcagggagct agaacgattc gcagttaatc 4440 ctggcctgtt agaaacatca gaaggctgta gacaaatact gggacagcta caaccatccc 4500 ttcagacagg atcagaggag cttcgatcac tatacaacac agtagcaacc ctctattgtg 4560 tgcaccagcg gatcgagatc aaggacacca aggaagcttt agacaagata gaggaagagc 4620 aaaacaagtc caagaagaag gcccagcagg cagcagctga cacaggacac agcaatcagg 4680 tcagccaaaa ttaccctata gtgcagaaca tccaggggca aatggtacat caggccatat 4740 cacctagaac tttaaatgca tgggtaaaag tagtagaaga gaaggctttc agcccagaag 4800 tgatacccat gttttcagca ttatcagaag gagccacccc acaggacctg aacacgatgt 4860 tgaacaccgt ggggggacat caagcagcca tgcaaatgtt aaaagagacc atcaatgagg 4920 aagctgcaga ttgggataga gtgcatccag tgcatgcagg gcctattgca ccaggccaga 4980 tgagagaacc aaggggaagt gacatagcag gaactactag tacccttcag gaacaaatag 5040 gatggatgac aaataatcca cctatcccag taggagagat ctacaagagg tggataatcc 5100 tgggattgaa caagatcgtg aggatgtata gccctaccag cattctggac ataagacaag 5160 gaccaaagga accctttaga gactatgtag accggttcta taaaactcta agagctgagc 5220 aagcttcaca ggaggtaaaa aattggatga cagaaacctt gttggtccaa aatgcgaacc 5280 cagattgtaa gaccatcctg aaggctctcg gcccagcggc tacactagaa gaaatgatga 5340 cagcatgtca gggagtagga ggacccggcc ataaggcaag agttttgtag ggatccacta 5400 gttctagact cgaggggggg cccggtacct ttaagaccaa tgacttacaa ggcagctgta 5460 gatcttagcc actttttaaa agaaaagggg ggactggaag ggctaattca ctcccaaaga 5520 agacaagata aaccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt 5580 ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta 5640 ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg 5700 ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc 5760 ggtgggctct atggcttctg aggcggaaag aaccagcaga tctgcagatc tgaattcatc 5820 tatgtcgggt gcggagaaag aggtaatgaa atggcattat gggtattatg ggtctgcatt 5880 aatgaatcgg ccagattatg ctggccaccg tgcatgtggc ctcgcacccc cgcaagacat 5940 ggcccgagtt cgagcacaac gtcatgaccc gctgcaatgt gcacctgggc tcccgccgag 6000 gcatgttcat gccataccag tgcaacatgc aatttgtgaa ggtgctgctg gagcccgatg 6060 ccatgtccag agtgagcctg acgggggtgt ttgacatgaa tgtggagctg tggaaaattc 6120 tgagatatga tgaatccaag accaggtgcc gggcctgcga atgcggaggc aagcacgcca 6180 ggcttcagcc cgtgtgtgtg gaggtgacgg aggacctgcg acccgatcat ttggtgttgt 6240 cctgcaacgg gacggagttc ggctccagcg gggaagaatc tgactagagt gagtagtgtt 6300 tgggggtggg tgggagcctg catgatgggc agaatgacta aaatctgtgt ttttctgcgc 6360 agcagcatga gcggaagcgc ctcctttgag ggaggggtat tcagccctta tctgacgggg 6420 cgtctcccct cctgggctgg agtgcgtcag aatgtgatgg gatccacggt ggacggccgg 6480 cccgtgcagc ccgcgaactc ttcaaccctg acctacgcga ccctgagctc ctcgtccgtg 6540 gacgcagctg ccgccgcagc tgctgcttcc gccgccagcg ccgtgcgcgg aatggccctg 6600 ggtgccggct actacagctc tctggtggcc aactcgagtt ccgccaataa tcccgccagc 6660 ctgaacgagg agaagctgct gctgctgatg gcccagctcg aggccctgac ccagcgcctg 6720 ggcgagctga cccagcaggt ggctcagctg caggcggaga cgcgggccgc ggttgccacg 6780 gtgaaaacca aataaaaaat gaatcaataa ataaacggaa acggttgttg attttaacac 6840 agagtcttga atctttattt gatttttcgc gcgcggtagg ccctggacca ccggtctcga 6900 tcattgagca cccggtggat cttttccagg acccggtaga ggtgggcttg gatgttgagg 6960 tacatgggca tgagcccgtc ccgggggtgg aggtagctcc actgcagggc ctcgtgctcg 7020 ggggtggtgt tgtaaatcac ccagtcatag caggggcgca gggcgtggtg ctgcacgatg 7080 tccttgagga ggagactgat ggccacgggc agtcccttgg tgtaggtgtt gacgaacctg 7140 ttgagctggg agggatgcat gcggggggag atgagatgca tcttggcctg gatcttgaga 7200 ttggcgatgt tcccacccag atcccgccgg gggttcatgt tgtgcaggac caccagcacg 7260 gtgtatccgg tgcacttggg gaatttgtca tgcaacttgg aagggaaggc gtgaaagaat 7320 ttggagacgc ccttgtgacc gcccaggttt tccatgcact catccatgat gatggcgatg 7380 ggcccgtggg cggcggcctg ggcaaagacg tttcgggggt cggacacatc gtagttgtgg 7440 tcctgggtga gctcgtcata ggccatttta atgaatttgg ggcggagggt gcccgactgg 7500 gggacaaagg tgccctcgat cccgggggcg tagttgccct cgcagatctg catctcccag 7560 gccttgagct cggagggggg gatcatgtcc acctgcgggg cgatgaaaaa aacggtttcc 7620 ggggcggggg agatgagctg ggccgaaagc aggttccgga gcagctggga cttgccgcag 7680 ccggtggggc cgtagatgac cccgatgacc ggctgcaggt ggtagttgag ggagagacag 7740 ctgccgtcct cgcggaggag gggggccacc tcgttcatca tctcgcgcac atgcatgttc 7800 tcgcgcacga gttccgccag gaggcgctcg ccccccagcg agaggagctc ttgcagcgag 7860 gcgaagtttt tcagcggctt gagtccgtcg gccatgggca ttttggagag ggtctgttgc 7920 aagagttcca gacggtccca gagctcggtg atgtgctcta gggcatctcg atccagcaga 7980 cctcctcgtt tcgcgggttg gggcggctgc gggagtaggg caccaggcga tgggcgtcca 8040 gcgaggccag ggtccggtcc ttccagggtc gcagggtccg cgtcagcgtg gtctccgtca 8100 cggtgaaggg gtgcgcgccg ggctgggcgc ttgcgagggt gcgcttcagg ctcatccggc 8160 tggtcgagaa ccgctcccgg tcggtgccct gcgcgtcggc caggtagcaa ttgagcatga 8220 gttcgtagtt gagcgcctcg gccgcgtggc ccttggcgcg gagcttacct ttggaagtgt 8280 gtccgcagac gggacagagg agggacttga gggcgtagag cttgggggcg aggaagacgg 8340 actcgggggc gtaggcgtcc gcgccgcagc tggcgcagac ggtctcgcac tccacgagcc 8400 aggtgaggtc ggggcggtcg gggtcaaaaa cgaggtttcc tccgtgcttt ttgatgcgtt 8460 tcttacctct ggtctccatg agctcgtgtc cccgctgggt gacaaagagg ctgtccgtgt 8520 ccccgtagac cgactttatg ggccggtcct cgagcggggt gccgcggtcc tcgtcgtaga 8580 ggaaccccgc ccactccgag acgaaggccc gggtccaggc cagcacgaag gaggccacgt 8640 gggaggggta gcggtcgttg tccaccagcg ggtccacctt ctccagggta tgcaagcaca 8700 tgtccccctc gtccacatcc aggaaggtga ttggcttgta agtgtaggcc acgtgaccgg 8760 gggtcccggc cgggggggta taaaaggggg cgggcccctg ctcgtcctca ctgtcttccg 8820 gatcgctgtc caggagcgcc agctgttggg gtaggtattc cctctcgaag gcgggcatga 8880 cctcggcact caggttgtca gtttctagaa acgaggagga tttgatattg acggtgccgt 8940 tggagacgcc tttcatgagc ccctcgtcca tctggtcaga aaagacgatc tttttgttgt 9000 cgagcttggt ggcgaaggag ccgtagaggg cattggagag gagcttggcg atggagcgca 9060 tggtctggtt cttttccttg tcggcgcgct ccttggcggc gatgttgagc tgcacgtact 9120 cgcgcgccac gcacttccat tcggggaaga cggtggtgag ctcgtcgggc acgattctga 9180 cccgccagcc gcggttgtgc agggtgatga ggtccacgct ggtggccacc tcgccgcgca 9240 ggggctcgtt ggtccagcag aggcgcccgc ccttgcgcga gcagaagggg ggcagcgggt 9300 ccagcatgag ctcgtcgggg gggtcggcgt ccacggtgaa gatgccgggc aggagctcgg 9360 ggtcgaagta gctgatgcag gtgcccagat cgtccagcgc cgcttgccag tcgcgcacgg 9420 ccagcgcgcg ctcgtagggg ctgaggggcg tgccccaggg catggggtgc gtgagcgcgg 9480 aggcgtacat gccgcagatg tcgtagacgt agaggggctc ctcgaggacg ccgatgtagg 9540 tggggtagca gcgccccccg cggatgctgg cgcgcacgta gtcgtacagc tcgtgcgagg 9600 gcgcgaggag ccccgcgccg aggttggagc gctgcggctt ttcggcgcgg tagacgatct 9660 ggcggaagat ggcgtgggag ttggaggaga tggtgggcct ctggaagatg ttgaagtggg 9720 cgtggggcag gccgaccgag tccctgatga agtgggcgta ggagtcctgc agcttggcga 9780 cgagctcggc ggtgacgagg acgtccaggg cgcagtagtc gagggtctct tggatgatgt 9840 cgtacttgag ctggcccttc tgcttccaca gctcgcggtt gagaaggaac tcttcgcggt 9900 ccttccagta ctcttcgagg gggaacccgt cctgatcggc acggtaagag cccaccatgt 9960 agaactggtt gacggccttg taggcgcagc agcccttctc cacggggagg gcataagctt 10020 gcgcggcctt gcgcagggag gtgtgggtga gggcgaaggt gtcgcgcacc atgaccttga 10080 ggaactggtg cttgaagtcg aggtcgtcgc agccgccctg ctcccagagt tggaagtccg 10140 tgcgcttctt gtaggcgggg ttgggcaaag cgaaagtaac atcgttgaag aggatcttgc 10200 ccgcgcgggg catgaagttg cgagtgatgc ggaaaggctg gggcacctcg gcccggttgt 10260 tgatgacctg ggcggcgagg acgatctcgt cgaagccgtt gatgttgtgc ccgacgatgt 10320 agagttccac gaatcgcggg cggcccttga cgtggggcag cttcttgagc tcgtcgtagg 10380 tgagctcggc ggggtcgctg agtccgtgct gctcaagggc ccagtcggcg acgtgggggt 10440 tggcgctgag gaaggaagtc cagagatcca cggccagggc ggtttgcaag cggtcccggt 10500 actgacggaa ctgctggccc acggccattt tttcgggggt gatgcagtag aaggtgcggg 10560 ggtcgccgtg ccagcggtcc cacttgagct ggagggcgag gtcgtgggcg agctcgacaa 10620 gcggcgggtc cccggagagt ttcatgacca gcatgaaggg gacgagctgc ttgccgaagg 10680 accccatcca ggtgtaggtt tccacatcgt aggtgaggaa gagcctttcg gtgcgaggat 10740 gcgagccgat ggggaagaac tggatctcct gccaccagtt ggaggaatgg ctgttgatgt 10800 gatggaagta gaaatgccga cggcgcgccg agcactcgtg cttgtgttta tacaagcgtc 10860 cgcagtgctc gcaacgctgc acgggatgca cgtgctgcac gagctgtacc tgagttcctt 10920 tgacgaggaa tttcagtggg cagtggagcg ctggcggctg catctggtgc tgtactacgt 10980 cctggccatc ggcgtggcca tcgtctgcct cgatggtggt catgctgacg agcccgcgcg 11040 ggaggcaggt ccagacctcg gctcggacgg gtcggagagc gaggacgagg gcgcgcaggc 11100 cggagctgtc cagggtcctg agacgctgcg gagtcaggtc agtgggcagc ggcggcgcgc 11160 ggttgacttg caggagcttt tccagggcgc gcgggaggtc cagatggtac ttgatctcca 11220 cggcgccgtt ggtggcgacg tccacggctt gcagggtccc gtgcccctgg ggcgccacca 11280 ccgtgccccg tttcttcttg ggcgctggcg gcgttggcgc tggttccatg tcggtcagaa 11340 gcggcggcga ggacgcgcgc cgggcggcag gggcggctcg gggcccggag gcaggggcgg 11400 caggggcacg tcggcgccgc gcgcgggcag gttctggtac tgcgcccgga gaagactggc 11460 gtgagcgacg acgcgacggt tgacgtcctg gatctgacgc ctctgggtga aggccacggg 11520 acccgtgagt ttgaacctga aagagagttc gacagaatca atctcggtat cgttgacggc 11580 ggcctgccgc aggatctctt gcacgtcgcc cgagttgtcc tggtaggcga tctcggtcat 11640 gaactgctcg atctcctcct cctgaaggtc tccgcggccg gcgcgctcga cggtggccgc 11700 gaggtcgttg gagatgcggg ccatgagctg cgagaaggcg ttcatgccgg cctcgttcca 11760 gacgcggctg tagaccacgg ctccgtcggg gtcgcgcgcg cgcatgacca cctgggcaag 11820 gttgagctcg acgtggcgcg tgaagaccgc gtagttgcag aggcgctggt agaggtagtt 11880 gagcgtggtg gcgatgtgct cggtgacgaa gaagtacatg atccagcggc ggagcggcat 11940 ctcgctgacg tcgcccaggg cttccaagcg ctccatggcc tcgtagaagt ccacggcgaa 12000 gttgaaaaac tgggagttgc gcgccgagac ggtcaactcc tcctccagaa gacggatgag 12060 ctctgcgatg gtggcgcgca cctcgcgctc gaaggccccg gggggctcct cttcttccat 12120 ctcctcctcc tcttcctcct ccactaacat ctcttctact tcctcctcag gcggtggtgg 12180 cgggggaggg ggcctgcgtc gccggcggcg cacgggcaga cggtcgatga agcgctcgat 12240 ggtctcgccg cgccggcgtc gcatggtctc ggtgacggcg cgcccgtcct cgcggggccg 12300 cagcgtgaag acgccgccgc gcatctccag gtggccgggg gggtccccgt tgggcaggga 12360 gagggcgctg acgatgcatc ttatcaattg ccccgtaggg actccgcgca aggacctgag 12420 cgtctcgaga tccacgggat ctgaaaaccg ttgaacgaag gcttcgagcc agtcgcagtc 12480 gcaaggtagg ctgagcacgg tttcttctgg cgggtcatgt tggttggagg gagcggggcg 12540 ggcgatgctg ctggtgatga agttgaaata ggcggttctg agacggcgga tggtggcgag 12600 gagcaccagg tctttgggcc cggcttgctg gatgcgcaga cggtcggcca tgccccaggc 12660 gtggtcctga cacctggcca ggtccttgta gtagtcctgc atgagccgct ccacgggcac 12720 ctcctcctcg cccgcgcggc cgtgcatgcg cgtgagcccg aagccgcgct ggggctggac 12780 gagcgccagg tcggcgacga cgcgctcggc gaggatggcc tgctggacct gggtgagggt 12840 ggtctggaag tcgtcgaagt cgacgaagcg gtggtaggct ccggtgttga tggtgtagga 12900 gcagttggcc atgacggacc agttgacggt ctggtggccg gggcgcacga gctcgtggta 12960 cttgaggcgc gagtaggcgc gcgtgtcgaa gatgtagtcg ttgcaggtgc gcacgaggta 13020 ctggtatccg acgaggaagt gcggcggcgg ctggcggtag agcggccatc gctcggtggc 13080 gggggcgccg ggcgcgaggt cctcgagcat gaggcggtgg tagccgtaga tgtacctgga 13140 catccaggtg atgccggcgg cggtggtgga ggcgcgcggg aactcgcgga cgcggttcca 13200 gatgttgcgc agcggcagga agtagttcat ggtggccgcg gtctggcccg tgaggcgcgc 13260 gcagtcgtgg atgctctaga catacgggca aaaacgaaag cggtcagcgg ctcgactccg 13320 tggcctggag gctaagcgaa cgggttgggc tgcgcgtgta ccccggttcg agtctctgct 13380 cgaatcaggc tggagccgca gctaacgtgg tactggcact cccgtctcga cccaagcctg 13440 ctaacgaaac ctccaggata cggaggcggg tcgttttttg gccttggtca ctggtcatga 13500 aaaactagta agcgcggaaa gcggccgccc gcgatggctc gctgccgtag tctggagaaa 13560 gaatcgccag ggttgcgttg cggtgtgccc cggttcgaga ctcagcgctc ggcgccggcc 13620 ggattccgcg gctaacgtgg gcgtggctgc cccgtcgttt ccaagacccc ttagccagcc 13680 gacttctcca gttacggagc gagcccctct ttttcttgtg tttttgccag atgcatcccg 13740 tactgcggca gatgcgcccc caccctccac cacaaccgcc cctaccgccg cagcagcagc 13800 aacagccggc gcttctgccc ccgccccagc agcagccagc cactaccgcg gcggccgccg 13860 tgagcggagc cggcgttcag tatgacctgg ccttggaaga gggcgagggg ctggcgcggc 13920 tgggggcgtc gtcgccggag cggcacccgc gcgtgcagat gaaaagggac gctcgcgagg 13980 cctacgtgcc caagcagaac ctgttcagag acaggagcgg cgaggagccc gaggagatgc 14040 gcgcctcccg cttccacgcg gggcgggagc tgcggcgcgg cctggaccga aagcgggtgc 14100 tgagggacga ggatttcgag gcggacgagc tgacggggat cagccccgcg cgcgcgcacg 14160 tggccgcggc caacctggtc acggcgtacg agcagaccgt gaaggaggag agcaacttcc 14220 aaaaatcctt caacaaccac gtgcgcacgc tgatcgcgcg cgaggaggtg accctgggcc 14280 tgatgcatct gtgggacctg ttggaggcca tcgtgcagaa ccccacgagc aagccgctga 14340 cggcgcagct gtttctggtg gtgcagcaca gtcgggacaa cgagacgttc agggaggcgc 14400 tgctgaatat caccgagccc gagggccgct ggctcctgga cctggtgaac attctgcaga 14460 gcatcgtggt gcaggagcgc gggctgccgc tgtccgagaa gctggcggcc atcaacttct 14520 cggtgctgag cctgggcaag tactacgcta ggaagatcta caagaccccg tacgtgccca 14580 tagacaagga ggtgaagatc gacgggtttt acatgcgcat gaccctgaaa gtgctgaccc 14640 tgagcgacga tctgggggtg taccgcaacg acaggatgca ccgcgcggtg agcgccagcc 14700 gccggcgcga gctgagcgac caggagctga tgcacagcct gcagcgggcc ctgaccgggg 14760 ccgggaccga gggggagagc tactttgaca tgggcgcgga cctgcgctgg cagcccagcc 14820 gccgggcttt agaggcagcc ggcggcgtgc cctacgtgga ggaggtggac gatgatgagg 14880 aggagggcga gtacctggaa gactgatggc gcgaccgtat ttttgctaga tgcagcaaca 14940 gccaccgcct cctgatcccg cgatgcgggc ggcgctgcag agccagccgt ccggcattaa 15000 ctcctcggac gattggaccc aggccatgca acgcatcatg gcgctgacga cccgcaatcc 15060 cgaagccttt agacagcagc ctcaggccaa ccggctctcg gccatcctgg aggccgtggt 15120 gccctcgcgc tcgaacccca cgcacgagaa ggtgctggcc atcgtgaacg cgctggtgga 15180 gaacaaggcc atccgcggcg acgaggccgg gctggtgtac aacgcgctgc tggagcgcgt 15240 ggcccgctac aacagcacca acgtgcagac gaacctggac cgcatggtga ccgacgtgcg 15300 cgaggcggtg tcgcagcgcg agcggttcca ccgcgagtcg aacctgggct ccatggtggc 15360 gctgaacgcc ttcctgagca cgcagcccgc caacgtgccc cggggccagg aggactacac 15420 caactttatc agcgcgctgc ggctgatggt ggccgaggtg ccccagagcg aggtgtacca 15480 gtcggggccg gactacttct tccagaccag tcgccagggc ttgcagaccg tgaacctgag 15540 ccaggctttc aagaacttgc agggactgtg gggcgtgcag gccccggtcg gggaccgcgc 15600 gacggtgtcg agcctgctga cgccgaactc gcgcctgctg ctgctgctgg tggcgccctt 15660 cacggacagc ggcagcgtga gccgcgactc gtacctgggc tacctgctta acctgtaccg 15720 cgaggccatc gggcaggcgc acgtggacga gcagacctac caggagatca cccacgtgag 15780 ccgcgcgctg ggccaggagg acccgggcaa cctggaggcc accctgaact tcctgctgac 15840 caaccggtcg cagaagatcc cgccccagta cgcgctgagc accgaggagg agcgcatcct 15900 gcgctacgtg cagcagagcg tggggctgtt cctgatgcag gagggggcca cgcccagcgc 15960 cgcgctcgac atgaccgcgc gcaacatgga gcccagcatg tacgcccgca accgcccgtt 16020 catcaataag ctgatggact acttgcatcg ggcggccgcc atgaactcgg actactttac 16080 caacgccatc ttgaacccgc actggctccc gccgcccggg ttctacacgg gcgagtacga 16140 catgcccgac cccaacgacg ggttcctgtg ggacgacgtg gacagcagcg tgttctcgcc 16200 gcgccccacc accaccgtgt ggaagaaaga gggcggggac cggcggccgt cctcggcgct 16260 gtccggtcgc gcgggtgctg ccgcggcggt gcccgaggcc gccagcccct tcccgagcct 16320 gcccttttcg ctgaacagcg tgcgcagcag cgagctgggt cggctgacgc ggccgcgcct 16380 gctgggcgag gaggagtacc tgaacgactc cttgttgagg cccgagcgcg agaaaaactt 16440 ccccaataac gggatagaga gcctggtgga caagatgagc cgctggaaga cgtacgcgca 16500 cgagcacagg gacgagcccc gagctagcag cagcgccggc gccacccgta gacgccagcg 16560 gcacgacagg cagcggggac tggtgtggga cgatgaggat tccgccgacg acagcagcgt 16620 gttggacttg ggtgggagtg gtggtggtaa cccgttcgct cacttgcgcc cccgtatcgg 16680 gcgcctgatg taagaatctg aaaaaataaa aaaacggtac tcaccaaggc catggcgacc 16740 agcgtgcgtt cttctctgtt gtttgtagta gtatgatgag gcgcgtgtac ccggagggtc 16800 ctcctccctc gtacgagagc gtgatgcagc aggcggtggc ggcggcgatg cagcccccgc 16860 tggaggcgcc ttacgtgccc ccgcggtacc tggcgcctac ggaggggcgg aacagcattc 16920 gttactcgga gctggcaccc ttgtacgata ccacccggtt gtacctggtg gacaacaagt 16980 cggcggacat cgcctcgctg aactaccaga acgaccacag caacttcctg accaccgtgg 17040 tgcagaacaa cgatttcacc cccacggagg ccagcaccca gaccatcaac tttgacgagc 17100 gctcgcggtg gggcggccag ctgaaaacca tcatgcacac caacatgccc aacgtgaacg 17160 agttcatgta cagcaacaag ttcaaggcgc gggtgatggt ctcgcgcaag acccccaacg 17220 gggtgacggt ggatgagaat tatgatggta gtcaggacga gctgacctac gagtgggtgg 17280 agtttgagct gcccgagggc aacttctcgg tgaccatgac catcgatctg atgaacaacg 17340 ccatcatcga caactacttg gcggtgggac ggcagaacgg ggtgctggag agcgacatcg 17400 gcgtgaagtt cgacacgcgc aacttccggc tgggctggga ccccgtgacc gagctggtga 17460 tgccgggcgt gtacaccaac gaggccttcc accccgacat cgtcctgctg cccggctgcg 17520 gcgtggactt caccgagagc cgcctcagca acctgctggg catccgcaag cggcagccct 17580 tccaggaggg cttccagatc ctgtacgagg acctggaggg gggcaacatc cccgcgctgc 17640 tggacgtcga agcctacgag aaaagcaagg aggaggccgc cgcagcggcg accgcggccg 17700 tggctaccgc tgcgaccacc gatgcagatg cagctactac taccaggggc gatacattcg 17760 ccacccaggc ggaggaagca gccgccctag cggcgaccga tgatagtgaa agtaagatag 17820 tcatcaagcc ggtggagaag gacagcaagg acaggagcta caacgttcta tcggatggaa 17880 agaacaccgc ctaccgcagc tggtacctgg cctacaacta cggcgaccct gagaagggcg 17940 tgcgctcctg gacgctgctc accacctcgg acgtcacctg cggcgtggag caagtctact 18000 ggtcgctgcc cgacatgatg caagacccgg tcaccttccg ctccacgcgt caagttagca 18060 actacccggt ggtgggcgcc gagctcctgc ccgtctactc caagagcttc ttcaacgagc 18120 aggccgtcta ctcgcagcag ctgcgcgcct tcacctcgct cacgcacgtc ttcaaccgct 18180 tccccgagaa ccagatcctc gtccgcccgc ccgcgcccac cattaccacc gtcagtgaaa 18240 acgttcctgc tctcacagat cacgggaccc tgccgctgcg cagcagtatc cggggagtcc 18300 agcgcgtgac cgtcactgac gccagacgcc gcacctgccc ctacgtctac aaggccctgg 18360 gcgtagtcgc gccgcgcgtc ctctcgagcc gcaccttcta aaaaatgtcc attctcatct 18420 cgcccagtaa taacaccggt tggggcctgc gcgcgcccag caagatgtac ggaggcgctc 18480 gccaacgctc cacgcaacac cccgtgcgcg tgcgcgggca cttccgcgct ccctggggcg 18540 ccctcaaggg ccgcgtgcgc tcgcgcacca ccgtcgacga cgtgatcgac caggtggtgg 18600 ccgacgcgcg caactacacg cccgccgccg cgcccgcctc caccgtggac gccgtcatcg 18660 acagcgtggt ggccgacgcg cgccggtacg cccgcgccaa gagccggcgg cggcgcatcg 18720 cccggcggca ccggagcacc cccgccatgc gcgcggcgcg agccttgctg cgcagggcca 18780 ggcgcacggg acgcagggcc atgctcaggg cggccagacg cgcggcctcc ggcagcagca 18840 gcgccggcag gacccgcaga cgcgcggcca cggcggcggc ggcggccatc gccagcatgt 18900 cccgcccgcg gcgcggcaac gtgtactggg tgcgcgacgc cgccaccggt gtgcgcgtgc 18960 ccgtgcgcac ccgcccccct cgcacttgaa gatgctgact tcgcgatgtt gatgtgtccc 19020 agcggcgagg aggatgtcca agcgcaaatt caaggaagag atgctccagg tcatcgcgcc 19080 tgagatctac ggccccgcgg cggcggtgaa ggaggaaaga aagccccgca aactgaagcg 19140 ggtcaaaaag gacaaaaagg aggaggaaga tgacggactg gtggagtttg tgcgcgagtt 19200 cgccccccgg cggcgcgtgc agtggcgcgg gcggaaagtg aaaccggtgc tgcggcccgg 19260 caccacggtg gtcttcacgc ccggcgagcg ttccggctcc gcctccaagc gctcctacga 19320 cgaggtgtac ggggacgagg acatcctcga gcaggcggcc gagcgtctgg gcgagtttgc 19380 ttacggcaag cgcagccgcc ccgcgccctt gaaagaggag gcggtgtcca tcccgctgga 19440 ccacggcaac cccacgccga gcctgaagcc ggtgaccctg cagcaggtgc tgccgagcgc 19500 ggcgccgcgc cggggcttca agcgcgaggg cggcgaggat ctgtacccga ccatgcagct 19560 gatggtgccc aagcgccaga agctggagga cgtgctggag cacatgaagg tggaccccga 19620 ggtgcagccc gaggtcaagg tgcggcccat caagcaggtg gccccgggcc tgggcgtgca 19680 gaccgtggac atcaagatcc ccacggagcc catggaaacg cagaccgagc ccgtgaagcc 19740 cagcaccagc accatggagg tgcagacgga tccctggatg ccggcgccgg cttccaccac 19800 caccaccacc cgccgaagac gcaagtacgg cgcggccagc ctgctgatgc ccaactacgc 19860 gctgcatcct tccatcatcc ccacgccggg ctaccgcggc acgcgcttct accgcggcta 19920 cagcagccgc cgcaagacca ccacccgccg ccgccgtcgc cgcacccgcc gcagcaccac 19980 cgcgacttcc gccgccgcct tggtgcggag agtgtaccgc agcgggcgtg agcctctgac 20040 cctgccgcgc gcgcgctacc acccgagcat cgccatttaa ctctgccgtc gcctccttgc 20100 agatatggcc ctcacatgcc gcctccgcgt ccccattacg ggctaccgag gaagaaagcc 20160 gcgccgtaga aggctgacgg ggaacgggct gcgtcgccat caccaccggc ggcggcgcgc 20220 catcagcaag cggttggggg gaggcttcct gcccgcgctg atccccatca tcgccgcggc 20280 gatcggggcg atccccggca tagcttccgt ggcggtgcag gcctctcagc gccactgaga 20340 cacagcttgg aaaatttgta ataaaaaaat ggactgacgc tcctggtcct gtgatgtgtg 20400 tttttagatg gaagacatca atttttcgtc cctggcaccg cgacacggca cgcggccgtt 20460 tatgggcacc tggagcgaca tcggcaacag ccaactgaac gggggcgcct tcaattggag 20520 cagtctctgg agcgggctta agaatttcgg gtccacgctc aaaacctatg gcagcaaggc 20580 gtggaacagc accacagggc aggcgctgag ggataagctg aaagagcaga acttccagca 20640 gaaggtggtc gatgggctcg cttcgggcat caacggggtg gtggacctgg ccaaccaggc 20700 cgtgcagcgg cagatcaaca gccgcctgga cccggtgccg cccgccggct ccgtggagat 20760 gccgcaggtg gaggaggagc tgcctcccct ggacaagcgg ggcgagaagc gaccccgccc 20820 cgacgcggag gagacgctgc tgacgcacac ggacgagccg cccccgtacg aggaggcggt 20880 gaaactgggt ctgcccacca cgcggcccat tgcgccccta gccaccgggg tgctgaaacc 20940 cgagagtaat aagcccgcga ccctggactt gcctcctccc cagccttccc gcccctccac 21000 agtggctaag cccctgccgc cggtggccgt ggcccgcgcg cgacccgggg gctccgcccg 21060 ccctcatgcg aactggcaga gcactctgaa cagcatcgtg ggtctgggag tgcagagtgt 21120 gaagcgccgc cgctgctatt aaacctaccg tagcgcttaa cttgcttgtc tgtgtgtgta 21180 tgtattatgt cgccgccgct gtccgccaga aggaggagtg aagaggcgcg tcgccgagtt 21240 gcaagatggc caccccatcg atgctgcccc agtgggcgta catgcacatc gccggacagg 21300 acgcttcgga gtacctgagt ccgggtctgg tgcagttcgc ccgcgccaca gacacctact 21360 tcagtctggg gaacaagttt aggaacccca cggtggcgcc cacgcacgat gtgaccaccg 21420 accgcagcca gcggctgacg ctgcgcttcg tgcccgtgga ccgcgaggac aacacctact 21480 cgtacaaagt gcgctacacg ctggccgtgg gcgacaaccg cgtgctggac atggccagca 21540 cctactttga catccgcggc gtgctggacc ggggccctag cttcaaaccc tactccggca 21600 ccgcctacaa cagcctggct cccaagggag cgcccaattc cagccagtgg gagcgagcta 21660 agacaaacaa taacggagcc acggaatctg ttacctttgg tgtggctgcc atggggggta 21720 tagatattac aaaagagggt ctccagattg gaactgatga aactaaagct gatagtaaag 21780 aaatttatgc agacaaaacc taccaacctg aacctcagat aggagaggag aactggcaag 21840 aaacattctc ctattatggc ggcagagctc ttaaaaaaga taccaagatg aagccatgct 21900 acggctcctt tgctaaacca acgaatgtca aaggaggtca ggccaaattt aaagttcagg 21960 acggtcaaca aactacagaa tatgatatcg acttagcttt ctttgatatt ccaaactctg 22020 gaacaggagg gaatggcacg aatgttaatt atgatccaga tatggtcatg tacactgaaa 22080 atgtggattt ggagacccct gatacccaca ttgtttacaa accagggact tccgatgaca 22140 gttctgaagc aaacttgctt cagcagtcca tgcctaacag acccaactat attgggttta 22200 gagacaactt tatcggtctc atgtactaca acagtactgg caatatgggt gtgctggctg 22260 gtcaggcctc ccagctgaat gctgtggtcg acttgcaaga cagaaacacc gagctatcct 22320 accagctctt gcttgactct ctgggcgata gaacccggta tttcagtatg tggaaccagg 22380 cggtggacag ttatgaccct gatgtgcgca ttattgaaaa ccatggtgtg gaagatgaac 22440 ttcccaacta ttgcttccca ttggatggag ctggtactaa tgctgtctat cagggtgtta 22500 aagcaaaaac taatggaggc gcagccaatg gagattggga gcaagataca gacgtgtcaa 22560 acattaacca gatatgcaag gggaacatct atgccatgga aatcaacctc caagccaacc 22620 tgtggagaag tttcctctac tcgaacgtgg ccctgtacct gcccgattct tacaagtaca 22680 cgccggccaa catcaccttg cccacgaata ccaacaccta tgattacatg aatgggagag 22740 tggcgcctcc ctcgttggtg gatgcctaca tcaacatcgg ggcgcgctgg tcgctggacc 22800 ccatggacaa cgtcaatccc ttcaaccacc accgcaacgc ggggctgcgc taccgctcca 22860 tgcttctggg caacgggcgc ttcgtgccct tccacatcca ggtgccccag aaatttttcg 22920 ccatcaagag cctcctgctc ctgcccgggt cctacaccta cgagtggaac ttccgcaagg 22980 acgtcaacat gatcctgcag agctccctcg gcaacgacct gcgcacggac ggggcctcca 23040 tctccttcac cagcatcaac ctctacgcca ccttcttccc catggcgcac aacacggcct 23100 ccacgctcga ggccatgctg cgcaacgaca ccaacgacca gtccttcaac gactacctct 23160 cggcggccaa catgctctac cccatcccag ccaacgccac caacgtgccc atctccatcc 23220 cctcgcgcaa ctgggccgcc ttccgcggct ggtccttcac gcgtctcaag accaaggaga 23280 cgccctcgct gggctccggg ttcgacccct acttcgtcta ctcgggctcc atcccctacc 23340 tcgacggcac cttctacctc aaccacacct tcaagaaggt ctccatcacc ttcgactcct 23400 ccgtcagctg gcccggcaac gaccggctcc tgacgcccaa cgagttcgaa atcaagcgca 23460 ccgtcgacgg cgagggctac aacgtggccc agtgcaacat gaccaaggac tggttcctgg 23520 tccagatgct ggcccactac aacatcggct accagggctt ctacgtgccc gagggctaca 23580 aggaccgcat gtactccttc ttccgcaact tccagcccat gagccgccag gtggtggacg 23640 aggtcaacta caaggactac caggccgtca ccctggccta ccagcacaac aactcgggct 23700 tcgtcggcta cctcgcgccc accatgcgcc agggccagcc ctaccccgcc aactacccgt 23760 acccgctcat cggcaagagc gccgtcacca gcgtcaccca gaaaaagttc ctctgcgaca 23820 gggtcatgtg gcgcatcccc ttctccagca acttcatgtc catgggcgcg ctcaccgacc 23880 tcggccagaa catgctctat gccaactccg cccacgcgct agacatgaat ttcgaagtcg 23940 accccatgga tgagtccacc cttctctatg ttgtcttcga agtcttcgac gtcgtccgag 24000 tgcaccagcc ccaccgcggc gtcatcgagg ccgtctacct gcgcaccccc ttctcggccg 24060 gtaacgccac cacctaagct cttgcttctt gcaagatggc tgagcccacg ggctccggcg 24120 agcaggagct cagggccatc atccgcgacc tgggctgcgg gccctacttc ctgggcacct 24180 tcgataagcg cttcccggga ttcatggccc cgcacaagct ggcctgcgcc atcgtcaaca 24240 cggccggccg cgagaccggg ggcgagcact ggctggcctt cgcctggaac ccgcgctcga 24300 acacctgcta cctcttcgac cccttcgggt tctcggacga gcgcctcaag cagatctacc 24360 agttcgagta cgagggcctg ctgcgccgca gcgccctggc caccgaggac cgctgcgtca 24420 ccctggaaaa gtccacccag accgtgcagg gtccgcgctc ggccgcctgc gggctctttt 24480 gctgcatgtt cctgcacgcc ttcgtgcact ggcccgaccg ccccatggac aagaacccca 24540 ccatgaactt gctgacgggg gtgcccaacg gcatgctcca gtcgccccag gtggaaccca 24600 ccctgcgccg caaccaggag gcgctctacc gcttcctcaa cgcccactcc gcctactttc 24660 gctcccaccg cgcgcgcatc gagaaggcca ccgccttcga ccgcatgaat caagacatgt 24720 aaaccgtgtg tgtatgtgaa tgctttattc ataataaaca gcacatgttt atgccacctt 24780 ctctgaggct ctgactttat ttagaaatcg aaggggttct gccggctctc ggcgtgcccc 24840 gcgggcaggg atacgttgcg gaactggtac ttgggcagcc acttgaactc ggggatcagc 24900 agcttcggca cggggaggtc ggggaacgag tcgctccaca gcttgcgcgt gagttgcagg 24960 gcgcccagca ggtcgggcgc ggagatcttg aaatcgcagt tgggacccgc gttctgcgcg 25020 cgagagttgc ggtacacggg gttgcagcac tggaacacca tcagggccgg gtgcttcacg 25080 ctcgccagca ccgtcgcgtc ggtgatgccc tccacgtcca gatcctcggc gttggccatc 25140 ccgaaggggg tcatcttgca ggtctgccgc cccatgctgg gcacgcagcc gggcttgtgg 25200 ttgcaatcgc agtgcagggg gatcagcatc atctgggcct gctcggagct catgcccggg 25260 tacatggcct tcatgaaagc ctccagctgg cggaaggcct gctgcgcctt gccgccctcg 25320 gtgaagaaga ccccgcagga cttgctagag aactggttgg tagcgcagcc cgcgtcgtgc 25380 acgcagcagc gcgcgtcgtt gttggccagc tgcaccacgc tgcgccccca gcggttctgg 25440 gtgatcttgg cccggtcggg gttctccttc agcgcgcgct gcccgttctc gctcgccaca 25500 tccatctcga tcgtgtgctc cttctggatc atcacggtcc cgtgcaggca ccgcagcttg 25560 ccctcggcct cggtgcagcc gtgcagccac agcgcgcagc cggtgctctc ccagttcttg 25620 tgggcgatct gggagtgcga gtgcacgaag ccctgcagga agcggcccat catcgcggtc 25680 agggtcttgt tgctggtgaa ggtcagcggg atgccgcggt gctcctcgtt cacatacagg 25740 tggcagatgc ggcggtacac ctcgccctgc tcgggcatca gctggaaggc ggacttcagg 25800 tcgctctcca cgcggtaccg gtccatcagc agcgtcatca cttccatgcc cttctcccag 25860 gccgaaacga tcggcaggct cagggggttc ttcaccgtca tcttagtcgc cgccgccgaa 25920 gtcagggggt cgttctcgtc cagggtctca aacactcgct tgccgtcctt ctcggtgatg 25980 cgcacggggg ggaaggcgaa gcccacggcc gccagctcct cctcggcctg cctttcgtcc 26040 tcgctgtcct ggctgatgtc ttgcaaaggc acatgcttgg tcttgcgggg tttctttttg 26100 ggcggcagag gcggcggcgg cggagacgtg ctgggcgagc gcgagttctc gctcaccacg 26160 actatttctt cttcttggcc gtcgtccgag accacgcggc ggtaggcatg cctcttctgg 26220 ggcagaggcg gaggcgacgg gctctcgcgg ttcggcgggc ggctggcaga gccccttccg 26280 cgttcggggg tgcgctcctg gcggcgctgc tctgactgac ttcctccgcg gccggccatt 26340 gtgttctcct agggagcaac aacaagcatg gagactcagc catcgtcgcc aacatcgcca 26400 tctgcccccg ccgccgccga cgagaaccag cagcagcaga atgaaagctt aaccgccccg 26460 ccgcccagcc ccacctccga cgccgcggcc ccagacatgc aagagatgga ggaatccatc 26520 gagattgacc tgggctacgt gacgcccgcg gagcacgagg aggagctggc agcgcgcttt 26580 tcagccccgg aagagaacca ccaagagcag ccagagcagg aagcagagag cgagcagagc 26640 caggctgggc tcgagcatgg cgactacctg agcggggcag aggacgtgct catcaagcat 26700 ctggcccgcc aatgcatcat cgtcaaggac gcgctgctcg accgcgccga ggtgcccctc 26760 agcgtggcgg agctcagccg cgcctacgag cgcaacctct tctcgccgcg cgtgcccccc 26820 aagcgccagc ccaacggcac ctgcgagccc aacccgcgcc tcaacttcta cccggtcttc 26880 gcggtgcccg aggccctggc cacctaccac ctctttttca agaaccaaag gatccccgtc 26940 tcctgccgcg ccaaccgcac ccgcgccgac gccctgctca acctgggccc cggcgcccgc 27000 ctacctgata tcgcctcctt ggaagaggtt cccaagatct tcgagggtct gggcagcgac 27060 gagactcggg ccgcgaacgc tctgcaagga agcggagagg agcatgagca ccacagcgcc 27120 ctggtggagt tggaaggcga caacgcgcgc ctggcggtcc tcaagcgcac ggtcgagctg 27180 acccacttcg cctacccggc gctcaacctg ccccccaagg tcatgagcgc cgtcatggac 27240 caggtgctca tcaagcgcgc ctcgcccctc tcggaggagg agatgcagga ccccgagagc 27300 tcggacgagg gcaagcccgt ggtcagcgac gagcagctgg cgcgctggct gggaacgagt 27360 agcacccccc agagtctgga agagcggcgc aagctcatga tggccgtggt cctggtgacc 27420 gtggagcttg agtgtctgcg ccgcttcttc gccgacgcgg agaccctgcg caaggtcgag 27480 gagaacctgc actacctctt caggcacggg ttcgtgcgcc aggcctgcaa gatctccaac 27540 gtggagctga ccaacctggt ctcctacatg ggcatcctgc acgagaaccg cctggggcag 27600 aacgtgctgc acaccaccct gcgcggggag gcccgccgcg actacatccg cgactgcgtc 27660 tacctgtacc tctgccacac ctggcagacg ggcatgggcg tgtggcagca gtgcctggag 27720 gagcagaacc tgaaagagct ctgcaagctc ctgcagaaga acctgaaggc cctgtggacc 27780 gggttcgacg agcgtaccac cgcctcggac ctggccgacc tcatcttccc cgagcgcctg 27840 cggctgacgc tgcgcaacgg gctgcccgac tttatgagcc aaagcatgtt gcaaaacttt 27900 cgctctttca tcctcgaacg ctccgggatc ctgcccgcca cctgctccgc gctgccctcg 27960 gacttcgtgc cgctgacctt ccgcgagtgc cccccgccgc tctggagcca ctgctacttg 28020 ctgcgcctgg ccaactacct ggcctaccac tcggacgtga tcgaggacgt cagcggcgag 28080 ggtctgctcg agtgccactg ccgctgcaac ctctgcacgc cgcaccgctc cctggcctgc 28140 aacccccagc tgctgagcga gacccagatc atcggcacct tcgagttgca aggccccggc 28200 gaggagggca aggggggtct gaaactcacc ccggggctgt ggacctcggc ctacttgcgc 28260 aagttcgtgc ccgaggacta ccatcccttc gagatcaggt tctacgagga ccaatcccag 28320 ccgcccaagg ccgagctgtc ggcctgcgtc atcacccagg gggccatcct ggcccaattg 28380 caagccatcc agaaatcccg ccaagaattt ctgctgaaaa agggccacgg ggtctacttg 28440 gacccccaga ccggagagga gctcaacccc agcttccccc agg atg ccc aga gga 28495 Met Pro Arg Gly 1 agc agc aag aag ctg aaa gtg gag ctg ccg ctg ccg ccg gag gat ttg 28543 Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Leu Pro Pro Glu Asp Leu 5 10 15 20 gag gaa gac tgg gag agc agt cag gca gag gag gag gag atg gaa gac 28591 Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu Glu Met Glu Asp 25 30 35 tgg gac agc act cag gca gag gag gac agc ctg caa gac agt ctg gaa 28639 Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser Leu Glu 40 45 50 gac gag gtg gag gag gca gag gaa gaa gca gcc gcc gcc aga ccg tcg 28687 Asp Glu Val Glu Glu Ala Glu Glu Glu Ala Ala Ala Ala Arg Pro Ser 55 60 65 tcc tcg gcg gag aaa gca agc agc acg gat acc atc tcc gct ccg ggt 28735 Ser Ser Ala Glu Lys Ala Ser Ser Thr Asp Thr Ile Ser Ala Pro Gly 70 75 80 cgg ggt ctc ggc ggc cgg gcc cac agt aga tgg gac gag acc ggg cgc 28783 Arg Gly Leu Gly Gly Arg Ala His Ser Arg Trp Asp Glu Thr Gly Arg 85 90 95 100 ttc ccg aac ccc acc acc cag acc ggt aag aag gag cgg cag gga tac 28831 Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys Glu Arg Gln Gly Tyr 105 110 115 aag tcc tgg cgg ggg cac aaa aac gcc atc gtc tcc tgc ttg caa gcc 28879 Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser Cys Leu Gln Ala 120 125 130 tgc ggg ggc aac atc tcc ttc acc cgg cgc tac ctg ctc ttc cac cgc 28927 Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu Leu Phe His Arg 135 140 145 ggg gtg aac ttc ccc cgc aac atc ttg cat tac tac cgt cac ctc cac 28975 Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr Arg His Leu His 150 155 160 agc ccc tac tac tgt ttc caa gaa gag gca gaa acc cag cag cag cag 29023 Ser Pro Tyr Tyr Cys Phe Gln Glu Glu Ala Glu Thr Gln Gln Gln Gln 165 170 175 180 aaa acc agc agc agc tagaaaatcc acagcggcgg cggcggcagg tggactgagg 29078 Lys Thr Ser Ser Ser 185 atcgcggcga acgagccggc gcagacccgg gagctgagga accggatctt tcccaccctc 29138 tatgccatct tccagcagag tcgggggcag gagcaggaac tgaaagtcaa gaaccgttct 29198 ctgcgctcgc tcacccgcag ttgtctgtat cacaagagcg aagaccaact tcagcgcact 29258 ctcgaggacg ccgaggctct cttcaacaag tactgcgcgc tcactcttaa agagtagccc 29318 gcgcccgccc acacacggaa aaaggcggga attacgtcac cacctgcgcc cttcgcccga 29378 ccatcatcat gagcaaagag attcccacgc cttacatgtg gagctaccag ccccagatgg 29438 gcctggccgc cggcgccgcc caggactact ccacccgcat gaactggctc agtgccgggc 29498 ccgcgatgat ctcacgggtg aatgacatcc gcgcccaccg aaaccagata ctcctagaac 29558 agtcagcgat caccgccacg ccccgccatc accttaatcc gcgtaattgg cccgccgccc 29618 tggtgtacca ggaaattccc cagcccacga ccgtactact tccgcgagac gcccaggccg 29678 aagtccagct gactaactca ggtgtccagc tggccggcgg cgccgccctg tgtcgtcacc 29738 gccccgctca gggtataaag cggctggtga tccgaggcag aggcacacag ctcaacgacg 29798 aggtggtgag ctcttcgctg ggtctgcgac ctgacggagt cttccaactc gccggatcgg 29858 ggagatcttc cttcacgcct cgtcaggccg tcctgacttt ggagagttcg tcctcgcagc 29918 cccgctcggg tggcatcggc actctccagt tcgtggagga gttcactccc tcggtctact 29978 tcaacccctt ctccggctcc cccggccact acccggacga gttcatcccg aacttcgacg 30038 ccatcagcga gtcggtggac ggctacgatt gaatgtccca tggtggcgcg gctgacctag 30098 ctcggcttcg acacctggac cactgccgcc gcttccgctg cttcgctcgg gatctcgccg 30158 agtttgccta ctttgagctg cccgaggagc accctcaggg cccggcccac ggagtgcgga 30218 tcatcgtcga agggggcctc gactcccacc tgcttcggat cttcagccag cgtccgatcc 30278 tggtcgagcg cgagcaagga cagacccgtc tgaccctgta ctgcatctgc aaccaccccg 30338 gcctgc atg aaa gtc ttt gtt gtc tgc tgt gta ctg agt ata ata aaa 30386 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys 190 195 gct gag atc agc gac tac tcc gga ctt ccg tgt gtt cct gaa tcc atc 30434 Ala Glu Ile Ser Asp Tyr Ser Gly Leu Pro Cys Val Pro Glu Ser Ile 200 205 210 215 aac cag tcc ctg ttc ttc acc ggg aac gag acc gag ctc cag ctc cag 30482 Asn Gln Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln 220 225 230 tgt aag ccc cac aag aag tac ctc acc tgg ctg ttc cag ggc tcc ccg 30530 Cys Lys Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro 235 240 245 atc gcc gtt gtc aac cac tgc gac aac gac gga gtc ctg ctg agc ggc 30578 Ile Ala Val Val Asn His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly 250 255 260 cct gcc aac ctt act ttt tcc acc cgc aga agc aag ctc cag ctc ttc 30626 Pro Ala Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe 265 270 275 caa ccc ttc ctc ccc ggg acc tat cag tgc gtc tcg gga ccc tgc cat 30674 Gln Pro Phe Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro Cys His 280 285 290 295 cac acc ttc cac ctg atc ccg aat acc aca gcg tcg ctc ccc gct act 30722 His Thr Phe His Leu Ile Pro Asn Thr Thr Ala Ser Leu Pro Ala Thr 300 305 310 aac aac caa act acc cac caa cgc cac cgt cgc gac ctt tcc tct gaa 30770 Asn Asn Gln Thr Thr His Gln Arg His Arg Arg Asp Leu Ser Ser Glu 315 320 325 tct aat acc act acc gga ggt gag ctc cga ggt cga cca acc tct ggg 30818 Ser Asn Thr Thr Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly 330 335 340 att tac tac ggc ccc tgg gag gtg gtg ggg tta ata gcg cta ggc cta 30866 Ile Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu 345 350 355 gtt gtg ggt ggg ctt ttg gct ctc tgc tac cta tac ctc cct tgc tgt 30914 Val Val Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys 360 365 370 375 tcg tac tta gtg gtg ctg tgt tgc tgg ttt aag aaa tgg ggc aga tca 30962 Ser Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser 380 385 390 ccc tagtgagctg cggtgtgctg gtggcggtgg tgctttcgat tgtgggactg 31015 Pro ggcggcgcgg ctgtagtgaa ggagaaggcc gatccctgct tgcatttcaa tcccgataaa 31075 tgccagctga gttttcagcc cgatggcaat cggtgcgcgg tgctgatcaa gtgcggatgg 31135 gaatgcgaga acgtgagaat cgagtacaat aacaagactc ggaacaatac tctcgcgtcc 31195 acgtggcagc ccggggaccc cgagtggtac accgtctctg tccccggtgc tgacggctcc 31255 ccgcgcaccg tgaataatac tttcattttt gcgcacatgt gcgacacggt catgtggatg 31315 agcaagcagt acgatatgtg gccccccacg aaggagaaca tcgtggtctt ctccatcgct 31375 tacagcctgt gcacggtgct aatcaccgct atcgtgtgcc tgagcattca catgctcatc 31435 gctattcgcc ccagaaataa tgccgaaaaa gaaaaacagc cataacacgt tttttcacac 31495 acctttttca gaccatggcc tctgttaaat ttttgctttt atttgccagt ctcattactg 31555 ttataagtaa tgagaaactc actatttaca ttggcactaa ccacactcta gaaggaattc 31615 caaaatcctc atggtattgc tattttgatc aagatccaga cttaactata gaactgtgtg 31675 gtaacaaggg acaaaataca agcattcatt taattaactt taaatgcgga gacgatttga 31735 aattaattaa tatcactaaa gagtatggag gtatgtatta ctatgttaca gaaaataaca 31795 acatgcagtt ttatgaagtt actgtaacta atcccaccac gcctagaaca acaacaacca 31855 ccacaaagac tacacctgtt accactatgc agctcactac caataacatt tttgccatgc 31915 gtcagaaggc caacaatagc accagcattc aacccccccc acccagtgag gaaattccca 31975 aatccatgat tggcattatt gttgctgtag tggtgtgcat gttgatcatc gccttgtgca 32035 tggtgtacta tgccttctgc tacagaaagc acagactgaa cgacaagcta gaacacttac 32095 taagtgttga attttaattt ttttagaacc atgaagatcc taggcctttt aattttttct 32155 atcattacct ctgctctatg caattctgac aatgaggacg ttactgtcgt tgtcggatca 32215 aattatacac tgaaaggtcc agcgaagggt atgctttcgt ggtattgctg gtttggaact 32275 gacactgaac aaaccgaatt atgcaatctt caaaatggca aagttcataa ttctaaaatt 32335 tacaattata tatgcaatgg cactgatttg atactcctca atatcacgaa atcatatgct 32395 ggcagttatt catgccctgg agatgatgct gacaatatga ttttttataa attgcaagtg 32455 gttgatccca ctactccacc tccacccacc acaactactc acaccacaca cacagaacaa 32515 accacagcag aggaggcggc aaagttagct ttgcaggtcc aagacagttc atttgttggc 32575 attaccccta cacccgatca gcggtgtccg gggctgctcg tcagcggcat tgtcggtgtg 32635 ctttcgggat tagcagttat aatcatctgc atgttcattt ttgcttgctg ctatagaagg 32695 ctttaccgac aaaaatcaga cccactgctg aacctctatg tttaattttt tccagagcca 32755 tgaaggcagt tagcgctcta gttttttgtt ctttgattgg cactgttttt agtgttagct 32815 ttttaaaaca aattaatgtt actgaggggg aaaatgtgac actggtaggc gtagaaggtg 32875 ctcaaaatac cacctggaca aaataccacc tcgatgggtg gaaagatatt tgcaattgga 32935 gtgtcattac ttacacatgt gagggagtta atttgaccat agtcaatgcc agccaaaatc 32995 agaagggttg gattaaaggg caatctgtta gtgttaccag tgaggggtac tatacccagc 33055 atactcttat ctatgacatt atagtcatac cgctgcctac gcctagccca cctagcacta 33115 ccacacagac aacccacact acacaaacaa ccacatacag tacatcaaat cagcctacca 33175 ccactacaac agcagaggtt gccagctcgt ctggggtccg agcggcattt ttgatgttgg 33235 ccccatctag cagtcccact gctagtacca atgagcagac tactgaattt ttgtccactg 33295 tcgagagcca caccacagct acctcgagtg ccttctctag caccgccaat ctctcctcgc 33355 tttcctctac accaatcagt cccgctacta ctactacccc cgctattctt cccactcccc 33415 tgaagcaaac tgaggacagc ggcatgcaat ggcagatcac cctgctcatt gtgatcgggt 33475 tggtcatcct agccgtgttg ctctactaca tcttccgccg ccgcattccc aacgcgcacc 33535 gcaagccggt ctacaagccc atcattgtcg ggcagccgga gccgcttcag gtggaagggg 33595 gtctaaggaa tcttctcttc tcttttacag tatggtgatt gaactatgat tcctagacaa 33655 ttcttgatca ctattcttat ctgcctcctc caagtctgtg ccaccctcgc tctggtggcc 33715 aacgccagtc cagactgtat tgggcccttc gcctcctacg tgctctttgc cttcatcacc 33775 tgcatctgct gctgtagcat agtctgcctg cttatcacct tcttccagtt cattgactgg 33835 atctttgtgc gcatcgccta cctgcgccac cacccccagt accgcgacca gcgagtggcg 33895 cagctgctca ggctcctctg ataagcatgc gggctctgct acttctcgcg cttctgctgt 33955 tagtgctccc ccgtcccgtt gacccccggc cccccactca gtcccccgag gaggtccgca 34015 aatgcaaatt ccaagaaccc tggaaattcc tcaaatgcta ccgccaaaaa tcagacatgc 34075 atcccagctg gatcatgatc attgggatcg tgaacattct ggcctgcacc ctcatctcct 34135 ttgtgattta cccctgcttt gactttggtt ggaactcgcc agaggcgctc tatctcccgc 34195 ctgaacctga cacaccacca cagcaacctc aggcacacgc actaccacca ccacagccta 34255 ggccacaata catgcccata ttagactatg aggccgagcc acagcgaccc atgctccccg 34315 ctattagtta cttcaatcta accggcggag atg act gac cca ctg gcc aac aac 34369 Met Thr Asp Pro Leu Ala Asn Asn 395 400 aac gtc aac gac ctt ctc ctg gac atg gac ggc cgc gcc tcg gag cag 34417 Asn Val Asn Asp Leu Leu Leu Asp Met Asp Gly Arg Ala Ser Glu Gln 405 410 415 cga ctc gcc caa ctt cgc att cgc cag cag cag gag aga gcc gtc aag 34465 Arg Leu Ala Gln Leu Arg Ile Arg Gln Gln Gln Glu Arg Ala Val Lys 420 425 430 gag ctg cag gac ggc ata gcc atc cac cag tgc aag aaa ggc atc ttc 34513 Glu Leu Gln Asp Gly Ile Ala Ile His Gln Cys Lys Lys Gly Ile Phe 435 440 445 tgc ctg gtg aaa cag gcc aag atc tcc tac gag gtc acc cag acc gac 34561 Cys Leu Val Lys Gln Ala Lys Ile Ser Tyr Glu Val Thr Gln Thr Asp 450 455 460 cat cgc ctc tcc tac gag ctc ctg cag cag cgc cag aag ttc acc tgc 34609 His Arg Leu Ser Tyr Glu Leu Leu Gln Gln Arg Gln Lys Phe Thr Cys 465 470 475 480 ctg gtc gga gtc aac ccc atc gtc atc acc cag cag tcg ggc gat acc 34657 Leu Val Gly Val Asn Pro Ile Val Ile Thr Gln Gln Ser Gly Asp Thr 485 490 495 aag ggg tgc atc cac tgc tcc tgc gac tcc ccc gac tgc gtc cac act 34705 Lys Gly Cys Ile His Cys Ser Cys Asp Ser Pro Asp Cys Val His Thr 500 505 510 ctg atc aag acc ctc tgc ggc ctc cgc gac ctc ctc ccc atg aac 34750 Leu Ile Lys Thr Leu Cys Gly Leu Arg Asp Leu Leu Pro Met Asn 515 520 525 taatcacccc cttatccagt gaaataaaga tcatattgat gattaaataa 34800 <210> 148 <211> 185 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 148 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Leu Pro 1 5 10 15 Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu 20 25 30 Glu Met Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln 35 40 45 Asp Ser Leu Glu Asp Glu Val Glu Glu Ala Glu Glu Glu Ala Ala Ala 50 55 60 Ala Arg Pro Ser Ser Ser Ala Glu Lys Ala Ser Ser Thr Asp Thr Ile 65 70 75 80 Ser Ala Pro Gly Arg Gly Leu Gly Gly Arg Ala His Ser Arg Trp Asp 85 90 95 Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys Glu 100 105 110 Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser 115 120 125 Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu 130 135 140 Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr 145 150 155 160 Arg His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu Ala Glu Thr 165 170 175 Gln Gln Gln Gln Lys Thr Ser Ser Ser 180 185 <210> 149 <211> 207 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 149 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Pro Cys Val Pro Glu Ser Ile Asn Gln 20 25 30 Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys 35 40 45 Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala 50 55 60 Val Val Asn His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala 65 70 75 80 Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro 85 90 95 Phe Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro Cys His His Thr 100 105 110 Phe His Leu Ile Pro Asn Thr Thr Ala Ser Leu Pro Ala Thr Asn Asn 115 120 125 Gln Thr Thr His Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser Asn 130 135 140 Thr Thr Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile Tyr 145 150 155 160 Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val Val 165 170 175 Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser Tyr 180 185 190 Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 195 200 205 <210> 150 <211> 135 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 150 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu Leu Leu Asp 1 5 10 15 Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg 20 25 30 Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Gly Ile Ala Ile 35 40 45 His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile 50 55 60 Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser Tyr Glu Leu Leu 65 70 75 80 Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val 85 90 95 Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys 100 105 110 Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu 115 120 125 Arg Asp Leu Leu Pro Met Asn 130 135 <210> 151 <211> 38673 <212> DNA <213> Artificial Sequence <220> <223> Simian adenovirus A1331clone <220> <221> misc_feature <222> (5)..(12) <223> Swa\I <220> <221> repeat_region <222> (14)..(142) <223> ITR <220> <221> misc_feature <222> (469)..(494) <223> I-Ceu recognition site <220> <221> misc_feature <222> (482)..(483) <223> cleavage point for bottom strand <220> <221> misc_feature <222> (486)..(487) <223> cleavage point for top strand <220> <221> misc_feature <222> (836)..(1096) <223> Enhancer <220> <221> misc_feature <222> (1097)..(1324) <223> CMV\promoter <220> <221> misc_feature <222> (1298)..(1301) <223> TATA <220> <221> CDS <222> (1420)..(2511) <223> Gag\short <220> <221> misc_feature <222> (2664)..(2866) <223> BGH-PolyA <220> <221> misc_feature <222> (2939)..(2977) <223> PI-Scel recognition sequence <220> <221> misc_feature <222> (2949)..(2950) <223> cleavage point on bottom strand <220> <221> misc_feature <222> (2953)..(2954) <223> cleavage point on top strand <220> <221> misc_feature <222> (3941)..(5562) <223> IVa2 complement (3941..5271,5551..5562) <220> <221> CDS <222> (10808)..(11983) <223> 52K <220> <221> CDS <222> (12010)..(13767) <223> pIIIa <220> <221> CDS <222> (13850)..(15466) <223> penton <220> <221> CDS <222> (15473)..(16054) <223> pVII <220> <221> CDS <222> (16102)..(17139) <223> V <220> <221> CDS <222> (17167)..(17397) <223> pX <220> <221> CDS <222> (17470)..(18186) <223> pVI <220> <221> CDS <222> (18290)..(21121) <223> hexon <220> <221> CDS <222> (21143)..(21766) <223> protease <220> <221> misc_feature <222> (21847)..(23382) <223> DBP complement (21847..23382 <220> <221> CDS <222> (23411)..(25819) <223> 100K <220> <221> CDS <222> (26427)..(27107) <223> pVIII <220> <221> CDS <222> (27111)..(27428) <223> E3\12.5K <220> <221> CDS <222> (27993)..(28520) <223> E3\gp19K <220> <221> CDS <222> (28557)..(29240) <223> E3\CR1-beta <220> <221> CDS <222> (29256)..(29864) <223> E3\CR1-gamma <220> <221> CDS <222> (29882)..(30745) <223> E3\CR1-delta <220> <221> CDS <222> (31037)..(31468) <223> E3\RID-beta <220> <221> CDS <222> (32165)..(33499) <223> fiber <220> <221> misc_feature <222> (33597)..(34750) <223> E4\orf6/7 complement (33597..33847,34580..34750) <220> <221> misc_feature <222> (33848)..(34750) <223> E4\orf6 complement (33848..34750) <220> <221> misc_feature <222> (34659)..(35021) <223> E4\orf4 complement (34659..35021) <220> <221> misc_feature <222> (35384)..(35770) <223> E4\orf2 complement (35384..35770) <220> <221> misc_feature <222> (35823)..(36194) <223> E4\orf1 complement (35823..36194) <220> <221> repeat_region <222> (36472)..(36600) <223> ITR <220> <221> misc_feature <222> (36604)..(36611) <223> Swa\I <220> <221> misc_feature <222> (36849)..(36849) <223> ORI <220> <221> misc_feature <222> (37607)..(38470) <223> AP(R) complement (27607..38470) <400> 151 aattatttaa atccwwymtm wataatatac ctcaaacttt tggtgcgcgt taatatgcaa 60 atgagccgtt tgaatttggg gatggaggaa ggtgattggc tgtgggagcg gcgaccgtta 120 ggggcggggc gggtgacgtt ttgatgacgt ggccatgagg cggagccggt ttgcaagttc 180 tcgtgggaaa agtgacgtca aacgaggtgt ggtttgaaca cggaaatact caattttccc 240 gcgctctctg acaggaaatg aggtgtttct gggcggatgc aagtgaaaac gggccatttt 300 cgcgcgaaaa ctgaatgagg aagtgaaaat ctgagtaatt ccgcgtttat ggcagggagg 360 agtatttgcc gagggccgag tagactttga ccgattacgt gggggtttcg attaccgtat 420 ttttcaccta aatttccgcg tacggtgtca aagtccggtg tttttacgta actataacgg 480 tcctaaggta gcgaaagctc agatctggat ctcccgatcc cctatggcga ctctcagtac 540 aatctgctct gatgccgcat agttaagcca gtatctgctc cctgcttgtg tgttggaggt 600 cgctgagtag tgcgcgagca aaatttaagc tacaacaagg caaggcttga ccgacaattg 660 catgaagaat ctgcttaggg ttaggcgttt tgcgctgctt cgcgatgtac gggccagata 720 tacgcgttga cattgattat tgactagtta ttaatagtaa tcaattacgg ggtcattagt 780 tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg 840 accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc 900 aatagggact ttccattgac gtcaatgggt ggactattta cggtaaactg cccacttggc 960 agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg 1020 gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat 1080 ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca tcaatgggcg 1140 tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag 1200 tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact ccgccccatt 1260 gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctcgtttagt 1320 gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata gaagacaccg 1380 ggaccgatcc agcctccgcg ggcgcgcgtc gacagagag atg ggt gcg aga gcg 1434 Met Gly Ala Arg Ala 1 5 tca gta tta agc ggg gga gaa tta gat cga tgg gaa aaa att cgg tta 1482 Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp Glu Lys Ile Arg Leu 10 15 20 agg cca ggg gga aag aag aag tac aag cta aag cac atc gta tgg gca 1530 Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys His Ile Val Trp Ala 25 30 35 agc agg gag cta gaa cga ttc gca gtt aat cct ggc ctg tta gaa aca 1578 Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro Gly Leu Leu Glu Thr 40 45 50 tca gaa ggc tgt aga caa ata ctg gga cag cta caa cca tcc ctt cag 1626 Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu Gln Pro Ser Leu Gln 55 60 65 aca gga tca gag gag ctt cga tca cta tac aac aca gta gca acc ctc 1674 Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn Thr Val Ala Thr Leu 70 75 80 85 tat tgt gtg cac cag cgg atc gag atc aag gac acc aag gaa gct tta 1722 Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp Thr Lys Glu Ala Leu 90 95 100 gac aag ata gag gaa gag caa aac aag tcc aag aag aag gcc cag cag 1770 Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys Lys Lys Ala Gln Gln 105 110 115 gca gca gct gac aca gga cac agc aat cag gtc agc caa aat tac cct 1818 Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val Ser Gln Asn Tyr Pro 120 125 130 ata gtg cag aac atc cag ggg caa atg gta cat cag gcc ata tca cct 1866 Ile Val Gln Asn Ile Gln Gly Gln Met Val His Gln Ala Ile Ser Pro 135 140 145 aga act tta aat gca tgg gta aaa gta gta gaa gag aag gct ttc agc 1914 Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu Glu Lys Ala Phe Ser 150 155 160 165 cca gaa gtg ata ccc atg ttt tca gca tta tca gaa gga gcc acc cca 1962 Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser Glu Gly Ala Thr Pro 170 175 180 cag gac ctg aac acg atg ttg aac acc gtg ggg gga cat caa gca gcc 2010 Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln Ala Ala 185 190 195 atg caa atg tta aaa gag acc atc aat gag gaa gct gca gat tgg gat 2058 Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu Ala Ala Asp Trp Asp 200 205 210 aga gtg cat cca gtg cat gca ggg cct att gca cca ggc cag atg aga 2106 Arg Val His Pro Val His Ala Gly Pro Ile Ala Pro Gly Gln Met Arg 215 220 225 gaa cca agg gga agt gac ata gca gga act act agt acc ctt cag gaa 2154 Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Thr Leu Gln Glu 230 235 240 245 caa ata gga tgg atg aca aat aat cca cct atc cca gta gga gag atc 2202 Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile Pro Val Gly Glu Ile 250 255 260 tac aag agg tgg ata atc ctg gga ttg aac aag atc gtg agg atg tat 2250 Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg Met Tyr 265 270 275 agc cct acc agc att ctg gac ata aga caa gga cca aag gaa ccc ttt 2298 Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly Pro Lys Glu Pro Phe 280 285 290 aga gac tat gta gac cgg ttc tat aaa act cta aga gct gag caa gct 2346 Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu Arg Ala Glu Gln Ala 295 300 305 tca cag gag gta aaa aat tgg atg aca gaa acc ttg ttg gtc caa aat 2394 Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr Leu Leu Val Gln Asn 310 315 320 325 gcg aac cca gat tgt aag acc atc ctg aag gct ctc ggc cca gcg gct 2442 Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala Leu Gly Pro Ala Ala 330 335 340 aca cta gaa gaa atg atg aca gca tgt cag gga gta gga gga ccc ggc 2490 Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly Pro Gly 345 350 355 cat aag gca aga gtt ttg tag ggatccacta gttctagact cgaggggggg 2541 His Lys Ala Arg Val Leu 360 cccggtacct ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa 2601 agaaaagggg ggactggaag ggctaattca ctcccaaaga agacaagata aaccgctgat 2661 cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt 2721 ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat 2781 cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg 2841 gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg 2901 aggcggaaag aaccagcaga tctgcagatc tgaattcatc tatgtcgggt gcggagaaag 2961 aggtaatgaa atggcacata tgctggccac cgtgcatgtg gcctcgcacc cccgcaagac 3021 atggcccgag ttcgagcaca acgtcatgac ccgctgcaat gtgcacctgg gctcccgccg 3081 aggcatgttc atgccatacc agtgcaacat gcaatttgtg aaggtgctgc tggagcccga 3141 tgccatgtcc agagtgagcc tggcgggggt gtttgacatg aatgtggagc tgtggaaaat 3201 tctgagatat gatgaatcca agaccaggtg ccgggcctgc gaatgcggag gcaagcacgc 3261 caggcttcag cccgtgtgtg tggaggtgac ggaggacctg cgacccgatc atttggtgtt 3321 gtcctgcaac gggacggagt tcggctccag cggggaagaa tctgactaga gtgagtagtg 3381 tttgggggcg ggtgggagcc tgcatgaggg gcagaatgac taaaatctgt gtttttctgt 3441 gcagcagcat gagcggaagc gcctcctttg agggaggggt attcagccct tatctgacgg 3501 ggcgtctccc ctcctgggcg ggagtgcgtc agaatgtgat gggatctacg gtggacggcc 3561 ggcccgtgca gcccgcgaac tcttcaaccc tgacctacgc gaccctgagc tcctcgtccg 3621 tggacgcagc tgccgccgca gctgctgctt ccgccgccag cgccgtgcgc ggaatggccc 3681 tgggcgccgg ctactacagc tctctggtgg ccaactcgag ttccaccaat aatcccgcca 3741 gcctgaacga ggagaagctg ctgctgctga tggcccagct cgaggccctg acccagcgcc 3801 tgggcgagct gacccagcag gtggctcagc tgcaggcgga gacgcgggcc gcggttgcca 3861 cggtgaaaac caaataaaaa atgaatcaat aaataaacgg agacggttgt tgattttaac 3921 acagagtctt gaatctttat ttgatttttc gcgcgcggta ggccctggac caccggtctc 3981 gatcattgag cacccggtgg atcttttcca ggacccggta gaggtgggct tggatgttga 4041 ggtacatggg catgagcccg tcccgggggt ggaggtagct ccattgcagg gcctcgtgct 4101 cgggggtggt gttgtaaatc acccagtcat agcaggggcg cagtgcgtgg tgctgcacga 4161 tgtccttgag gaggagactg atggccacgg gcagcccctt ggtgtaggtg ttgacgaacc 4221 tgttgagctg ggagggatgc atgcgggggg agatgagatg catcttggcc tggatcttga 4281 gattggcgat gttcccgccc agatcccgcc gggggttcat gttgtgcagg accaccagca 4341 cggtgtatcc ggtgcacttg gggaatttgt catgcaactt ggaagggaag gcgtgaaaga 4401 atttggagac gcccttgtga ccgcccaggt tttccatgca ctcatccatg atgatggcga 4461 tgggcccgtg ggcggcggcc tgggcaaaga cgtttcgggg gtcggacaca tcgtagttgt 4521 ggtcctgggt gagctcgtca taggccattt taatgaattt ggggcggagg gtgcccgact 4581 gggggacgaa ggtgccttcg atcccggggg cgtagttgcc ctcgcagatc tgcatctccc 4641 aggccttgag ctcggagggg gggatcatgt ccacctgcgg ggcgatgaaa aaaacggttt 4701 ccggggcggg ggagatgagc tgcgccgaaa gcaggttccg gagcagctgg gacttgccgc 4761 agccggtggg gccgtagatg accccgatga ccggctgcag gtggtagttg agggagagac 4821 agctgccgtc ctcgcgtagg aggggggcca cctcgttcat catctcgcgc acatgcatgt 4881 tctcgcgcac gagttccgcc aggaggcgct cgccccccag cgagaggagc tcttgcagcg 4941 aggcgaagtt tttcagcggc ttgagcccgt cggccatggg cattttggag agggtctgtt 5001 gcaagagttc cagacggtcc cagagctcgg tgatgtgctc tacggcatct cgatccagca 5061 gacctcctcg tttcgcgggt tgggacgact gcgggagtag ggcaccagac gatgggcgtc 5121 cagcgcagcc agggtccggt ccttccaggg tcgcagcgtc cgcgtcagcg tggtctccgt 5181 cacggtgaag gggtgcgcgc cgggctgggc gcttgcgagg gtgcgcttca ggctcatccg 5241 gctggtcgag aaccgctccc gatcggcgcc ctgcgcgtcg gccaggtagc aattgaccat 5301 gagttcgtag ttgagcgcct cggccgcgtg gcctttggcg cggagcttac ctttggaagt 5361 ctgcccgcag gcgggacaga ggagggactt gagggcgtag agcttggggg cgaggaagac 5421 ggactcgggg gcgtaggcgt ccgcgccgca gtgggcgcag acggtctcgc actccacaag 5481 ccaggtgagg tcgggctggt cggggtcaaa aaccagtttt ccgccgttct ttttgatgcg 5541 tttcttacct ttggtctcca tgagctcgtg tccccgctgg gtgacaaaga ggctgtccgt 5601 gtccccgtag accgacttta tgggccggtc ctcgagcggt gtgccacggt cctcctcgta 5661 gaggaacccc gcccactccg agacgaaagc ccgggtccag gccagcacga aggaggccac 5721 gtgggacggg tagcggtcgt tgtccaccag cgggtccact ttctccaggg tatgcaaaca 5781 catgtccccc tcgtccacat ccaggaaggt gattggcttg taagtgtagg ccacgtgacc 5841 gggggtcccg gccggggggg tataaaaggg ggcgggcccc tgctcgtcct cactgtcttc 5901 cggatcgctg tccaggagcg ccagctgttg gggtaggtat tccctctcga aggcgggcat 5961 gacctcggca ctcaggttgt cagtttctag aaacgaggag gatttgatat tgacggtgcc 6021 gttggagacg cctttcatga gcccctcgtc catctggtca gaaaagacga tctttttgtt 6081 gtcgagcttg gtggcgaagg agccgtagag ggcgttggag agcagcttgg cgatggagcg 6141 catggtctgg ttcttttcct tgtcggcgcg ctccttggcg gcgatgttga gctgcacgta 6201 ctcgcgcgcc acgcacttcc attcggggaa gacggtggtg agctcgtcgg gcacgattct 6261 gacccgccag ccgcggttgt gcagggtgat gaggtccacg ctggtggcca cctcgccgcg 6321 caggggctcg ttggtccagc agaggcgccc gcccttgcgc gagcagaagg ggggcagcgg 6381 gtccagcatg agctcgtcgg gggggtcggc gtccacggtg aagatgccgg gcaggagctc 6441 ggggtcgaag tagctgatgc aggtgcccag atcgtccagc gccgcttgcc agtcgcgcac 6501 ggccagcgcg cgctcgtagg ggctgagggg cgtgccccag ggcatggggt gcgtgagcgc 6561 ggaggcgtac atgccgcaga tgtcgtagac gtagaggggc tcctcgagga cgccgatgta 6621 ggtggggtag cagcgccccc cgcggatgct ggcgcgcacg tagtcgtaca gctcgtgcga 6681 gggcgcgagg agccccgcgc cgaggttgga gcgctgcggc ttttcggcgc ggtagacgat 6741 ctggcggaag atggcgtggg agttggagga gatggtgggc ctctggaaga tgttgaagtg 6801 ggcgtggggc aggccgaccg agtccctgat gaagtgggcg taggagtcct gcagcttggc 6861 gacgagctcg gcggtgacga ggacgtccag ggcgcagtag tcgagggtct cttggatgat 6921 gtcgtacttg agctggccct tctgcttcca cagctcgcgg ttgagaagga actcttcgcg 6981 gtccttccag tactcttcga gggggaaccc gtcctgatcg gcacggtaag agcccaccat 7041 gtagaactgg ttgacggcct tgtaggcgca gcagcccttc tccacgggga gggcgtaagc 7101 ttgcgcggcc ttgcgcaggg aggtgtgggt gagggcgaag gtgtcgcgca ccatgacctt 7161 gaggaactgg tgcttgaagt cgaggtcgtc gcagccgccc tgctcccaga gttggaagtc 7221 cgtgcgcttc ttgtaggcgg ggttgggcaa agcgaaagta acatcgttga agaggatctt 7281 gcccgcgcgg ggcatgaagt tgcgagtgat gcggaaaggc tggggcacct cggcccggtt 7341 gttgatgacc tgggcggcga ggacgatctc gtcgaagccg ttgatgttgt gcccgacgat 7401 gtagagttcc acgaatcgcg ggcggccctt gacgtggggc agcttcttga gctcgtcgta 7461 ggtgagctcg gcggggtcgc tgagcccgtg ctgctcaagg gcccagtcgg cgacgtgggg 7521 gttggcgctg aggaaggaag tccagagatc cacggccagg gcggtttgca agcggtcccg 7581 gtactgacgg aactgctggc ccacggccat tttttcgggg gtgatgcagt agaaggtgcg 7641 ggggtcgccg tgccagcggt cccacttgag ctggagggcg aggtcgtggg cgagctcgac 7701 gagcggcggg tccccggaga gtttcatgac cagcatgaag gggacgagct gcttgccgaa 7761 ggaccccatc caggtgtagg tttccacatc gtaggtgagg aagagccttt cggtgcgagg 7821 atgcgagccg atggggaaga actggatctc ctgccaccag ttggaggaat ggctgttgat 7881 gtgatggaag tagaaatgcc gacggcgcgc cgagcactcg tgcttgtgtt tatacaagcg 7941 tccgcagtgc tcgcaacgct gcacgggatg cacgtgctgc acgagctgta cctgggttcc 8001 tttgacgagg aatttcagtg ggcagtggag cgctggcggc tgcatctggt gctgtactac 8061 gtcctggcca tcggcgtggc catcgtctgc ctcgatggtg gtcatgctga cgagcccgcg 8121 cgggaggcag gtccagacct cggctcggac gggtcggaga gcgaggacga gggcgcgcag 8181 gccggagctg tccagggtcc tgagacgctg cggagtcagg tcagtgggca gcggcggcgc 8241 gcggttgact tgcaggagct tttccagggc gcgcgggagg tccagatggt acttgatctc 8301 cacggcgccg ttggtggcga cgtccacggc ttgcagggtc ccgtgcccct ggggcgccac 8361 caccgtgccc cgtttcttct tgggcgctgg cgttggcgct gcttccatgt cggtcagaag 8421 cggcggcgag gacgcgcgcc gggcggcagg ggcggctcgg ggcccggagg caggggcggc 8481 aggggcacgt cggcgccgcg cgcgggcagg ttctggtact gcgcccggag aagactggcg 8541 tgagcgacga cgcgacggtt gacgtcctgg atctgacgcc tctgggtgaa ggccacggga 8601 cccgtgagtt tgaacctgaa agagagttcg acagaatcaa tctcggtatc gttgacggcg 8661 gcctgccgca ggatctcttg cacgtcgccc gagttgtcct ggtaggcgat ctcggtcatg 8721 aactgctcga tctcctcctc ctgaaggtct ccgcggccgg cgcgctcgac ggtggccgcg 8781 aggtcgttgg agatgcggcc catgagctgc gagaaggcgt tcatgccggc ctcgttccag 8841 acgcggctgt agaccacgga tccgtcgggg tcgcgcgcgc gcatgaccac ctgggcgagg 8901 ttgagctcca cgtggcgcgt gaagaccgcg tagttgcaga ggcgctggta gaggtagttg 8961 agcgtggtgg cgatgtgctc ggtgacgaag aagtacatga tccagcggcg gagcggcatc 9021 tcgctgacgt cgcccagggc ttccaagcgc tccatggcct cgtagaagtc cacggcgaag 9081 ttgaaaaact gggagttgcg cgccgagacg gtcaactcct cctccagaag acggatgagc 9141 tcggcgatgg tggcgcgcac ctcgcgctcg aaggccccgg ggggctcctc ttccatctcc 9201 tcctcttctt cctcctccac taacatctct tctacttcct cctcaggagg cggcggcggg 9261 ggagggggcc tgcgtcgccg gcggcgcacg ggcagacggt cgatgaagcg ctcgatggtc 9321 tccccgcgcc ggcgacgcat ggtctcggtg acggcgcgcc cgtcctcgcg gggccgcagc 9381 gtgaagacgc cgccgcgcat ctccaggtgg ccgccggggg ggtctccgtt gggcagggag 9441 agggcgctga cgatgcatct tatcaattga cccgtaggga ctccgcgcaa ggacctgagc 9501 gtctcgagat ccacgggatc cgaaaaccgc tgaacgaagg cttcgagcca gtcgcagtcg 9561 caaggtaggc tgagcccggt ttcttcttcg gggatttgct ggtcgggagg cgggcgggcg 9621 atgctgctgg tgatgaagtt gaagtaggcg gtcctgagac ggcggatggt ggcgaggagc 9681 accaggtcct tgggcccggc ttgctggatg cgcagacggt cggccatgcc ccaggcgtgg 9741 tcctgacacc tggcgaggtc cttgtagtag tcctgcatga gccgctccac gggcacctcc 9801 tcctcgcccg cgcggccgtg catgcgcgtg agcccgaacc cgcgctgggg ctggacgagc 9861 gccaggtcgg cgacgacgcg ctcggcgagg atggcctgct ggatctgggt gagggtggtc 9921 tggaagtcgt cgaagtcgac gaagcggtgg taggctccgg tgttgatggt gtaggagcag 9981 ttggccatga cggaccagtt gacggtctgg tggccggggc gcacgagctc gtggtacttg 10041 aggcgcgagt aggcgcgcgt gtcgaagatg tagtcgttgc aggtgcgcac gaggtactgg 10101 tatccgacga ggaagtgagg cggcggctgg cggtagagcg gccatcgctc ggtggcgggg 10161 gcgccgggcg cgaggtcttc gagcatgagg cggtggtagc cgtagatgta cctggacatc 10221 caggtgatgc cagcggcggt ggtggaggcg cgcgggaact cgcggacgcg gttccagatg 10281 ttgcgcagcg gcaggaagta gttcatggtg gccgcggtct ggcccgtgag gcgcgcgcag 10341 tcgtggatgc tctagacata cgggcaaaaa cgaaagcggt cagcggctcg actccgtggc 10401 ctggaggcta agcgaacggg ttgggctgcg cgtgtacccc ggttcgagtc cctgctcgaa 10461 tcaggctgga gccgcagcta acgtggtact ggcactcccg tctcgaccca agcctgctaa 10521 cgaaacctcc aggatacgga ggcgggtcgt tttttggcct tggtcactgg tcatgaaaaa 10581 ctagtaagcg cggaaagcgg ccgcccgcga tggctcgctg ccgtagtctg gagaaagaat 10641 cgccagggtt gcgttgcggt gtgccccggt tcgagcctca gcgctcggcg ccggccggat 10701 tccgcggcta acgtgggcgt ggctgccccg tcgtttccaa gaccccttag ccagccgact 10761 tctccagtta cggagcgagc ccctcttttt cttgtgtttt tgccag atg cat ccc 10816 Met His Pro 365 gta ctg cgg cag atg cgc ccc cac cct cca cct caa ccg ccc cta ccg 10864 Val Leu Arg Gln Met Arg Pro His Pro Pro Pro Gln Pro Pro Leu Pro 370 375 380 cag cag cag caa cag ccg gcg ctt ttg ccc ccg ccc cag cag cag cag 10912 Gln Gln Gln Gln Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln Gln 385 390 395 cag cca gcc act acc gcg gcg gcc gcc gtg agc gga gcc ggc gtt caa 10960 Gln Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala Gly Val Gln 400 405 410 tat gac ctg gcc ttg gaa gag ggc gag ggg ctg gcg cgg ctg ggg gcg 11008 Tyr Asp Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala Arg Leu Gly Ala 415 420 425 430 tcg tcg ccg gag cgg cac ccg cgc gtg cag atg aaa agg gac gct cgc 11056 Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys Arg Asp Ala Arg 435 440 445 gag gcc tac gtg ccc aag cag aac ctg ttc aga gac agg agc ggc gag 11104 Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp Arg Ser Gly Glu 450 455 460 gag ccc gag gag atg cgc gcc tcc cgc ttc cac gcg ggg cgg gag ctg 11152 Glu Pro Glu Glu Met Arg Ala Ser Arg Phe His Ala Gly Arg Glu Leu 465 470 475 cgg cgc ggc ctg gac cga aag cgg gtg ctg agg gac gag gat ttc gag 11200 Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp Glu Asp Phe Glu 480 485 490 gcg gac gag ctg acg ggg atc agc ccc gcg cgc gcg cac gtg gcc gcg 11248 Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala His Val Ala Ala 495 500 505 510 gcc aac ctg gtc acg gcg tac gag cag acc gtg aag gag gag agc aac 11296 Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys Glu Glu Ser Asn 515 520 525 ttc caa aaa tcc ttc aac aac cac gtg cgc acg ctg atc gcg cgc gag 11344 Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu Ile Ala Arg Glu 530 535 540 gag gtg acc ctg ggc ctg atg cac ctg tgg gac ctg ctg gag gcc atc 11392 Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu Leu Glu Ala Ile 545 550 555 gtg cag aac ccc acg agc aag ccg ctg acg gcg cag ctg ttc ctg gtg 11440 Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln Leu Phe Leu Val 560 565 570 gtg cag cac agt cgg gac aac gag acg ttc agg gag gcg ctg ctg aat 11488 Val Gln His Ser Arg Asp Asn Glu Thr Phe Arg Glu Ala Leu Leu Asn 575 580 585 590 atc acc gag ccc gag ggc cgc tgg ctc ctg gac ctg gtg aac att ctg 11536 Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu Val Asn Ile Leu 595 600 605 cag agc atc gtg gtg cag gag cgc ggg ctg ccg ctg tcc gag aag ctg 11584 Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu Ser Glu Lys Leu 610 615 620 gcg gcc atc aac ttc tcg gtg ctg agc ctg ggc aag tac tac gct agg 11632 Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys Tyr Tyr Ala Arg 625 630 635 aag atc tac aag acc ccg tac gtg ccc ata gac aag gag gtg aag atc 11680 Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys Glu Val Lys Ile 640 645 650 gat ggg ttt tac atg cgc atg acc ctg aaa gtg ctg acc ctg agc gac 11728 Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu Thr Leu Ser Asp 655 660 665 670 gat ctg ggg gtg tac cgc aac gac agg atg cac cgc gcg gtg agc gcc 11776 Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg Ala Val Ser Ala 675 680 685 agc cgc cgg cgc gag ctg agc gac cag gag ctg atg cac agc ctg cag 11824 Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met His Ser Leu Gln 690 695 700 cgg gcc ctg acc ggg gcc ggg acc gag ggg gag agc tac ttt gac atg 11872 Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser Tyr Phe Asp Met 705 710 715 ggc gcg gac ctg cgc tgg cag ccc agc cgc cgg gcc ttg gaa gct gcc 11920 Gly Ala Asp Leu Arg Trp Gln Pro Ser Arg Arg Ala Leu Glu Ala Ala 720 725 730 ggc ggc gtg ccc tac gtg gag gag gtg gac gat gag gag gag gag ggc 11968 Gly Gly Val Pro Tyr Val Glu Glu Val Asp Asp Glu Glu Glu Glu Gly 735 740 745 750 gag tac ctg gaa gac tgatggcgcg accgtatttt tgctag atg cag caa cag 12021 Glu Tyr Leu Glu Asp Met Gln Gln Gln 755 cca ccg cct cct gat ccc gcg atg cgg gcg gcg ctg cag agc cag ccg 12069 Pro Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu Gln Ser Gln Pro 760 765 770 775 tcc ggc att aac tcc tcg gac gat tgg acc cag gcc atg caa cgc atc 12117 Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala Met Gln Arg Ile 780 785 790 atg gcg ctg acg acc cgc aat ccc gaa gcc ttt aga cag cag cct cag 12165 Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg Gln Gln Pro Gln 795 800 805 gcc aac cgg ctc tcg gcc atc ctg gag gcc gtg gtg ccc tcg cgc tcg 12213 Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val Pro Ser Arg Ser 810 815 820 aac ccc acg cac gag aag gtg ctg gcc atc gtg aac gcg ctg gtg gag 12261 Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn Ala Leu Val Glu 825 830 835 aac aag gcc atc cgc ggc gac gag gcc ggg ctg gtg tac aac gcg ctg 12309 Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val Tyr Asn Ala Leu 840 845 850 855 ctg gag cgc gtg gcc cgc tac aac agc acc aac gtg cag acg aac ctg 12357 Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val Gln Thr Asn Leu 860 865 870 gac cgc atg gtg acc gac gtg cgc gag gcg gtg tcg cag cgc gag cgg 12405 Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ser Gln Arg Glu Arg 875 880 885 ttc cac cgc gag tcg aac ctg ggc tcc atg gtg gcg ctg aac gcc ttc 12453 Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala Leu Asn Ala Phe 890 895 900 ctg agc acg cag ccc gcc aac gtg ccc cgg ggc cag gag gac tac acc 12501 Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln Glu Asp Tyr Thr 905 910 915 aac ttc atc agc gcg ctg cgg ctg atg gtg gcc gag gtg ccc cag agc 12549 Asn Phe Ile Ser Ala Leu Arg Leu Met Val Ala Glu Val Pro Gln Ser 920 925 930 935 gag gtg tac cag tcg ggg ccg gac tac ttc ttc cag acc agt cgc cag 12597 Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr Ser Arg Gln 940 945 950 ggc ttg cag acc gtg aac ctg agc cag gct ttc aag aac ttg cag gga 12645 Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys Asn Leu Gln Gly 955 960 965 ctg tgg ggc gtg cag gcc ccg gtc ggg gac cgc gcg acg gtg tcg agc 12693 Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala Thr Val Ser Ser 970 975 980 ctg ctg acg ccg aac tcg cgc ctg ctg ctg ctg ctg gtg gcg ccc ttc 12741 Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu Val Ala Pro Phe 985 990 995 acg gac agc ggc agc gtg agc cgc gac tcg tac ctg ggc tac ctg 12786 Thr Asp Ser Gly Ser Val Ser Arg Asp Ser Tyr Leu Gly Tyr Leu 1000 1005 1010 ctt aac ctg tac cgc gag gcc atc ggg cag gcg cac gtg gac gag 12831 Leu Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp Glu 1015 1020 1025 cag acc tac cag gag atc acc cac gtg agc cgc gcg ctg ggc cag 12876 Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly Gln 1030 1035 1040 gag gac ccg ggc aac ctg gag gcc acc ctg aac ttc ctg ctg acc 12921 Glu Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr 1045 1050 1055 aac cgg tcg cag aag atc ccg ccc cag tac gcg ctg agc acc gag 12966 Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu 1060 1065 1070 gag gag cgc atc ctg cgc tac gtg cag cag agc gtg ggg ctg ttc 13011 Glu Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe 1075 1080 1085 ctg atg cag gag ggg gcc acg ccc agc gcc gcg ctc gac atg acc 13056 Leu Met Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr 1090 1095 1100 gcg cgc aac atg gag ccc agc atg tac gcc cgc aac cgc ccg ttc 13101 Ala Arg Asn Met Glu Pro Ser Met Tyr Ala Arg Asn Arg Pro Phe 1105 1110 1115 atc aat aag ctg atg gac tac ttg cat cgg gcg gcc gcc atg aac 13146 Ile Asn Lys Leu Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn 1120 1125 1130 tcg gac tac ttt acc aac gcc atc ttg aac ccg cac tgg ctc ccg 13191 Ser Asp Tyr Phe Thr Asn Ala Ile Leu Asn Pro His Trp Leu Pro 1135 1140 1145 ccg ccc ggg ttc tac acg ggc gag tac gac atg ccc gac ccc aac 13236 Pro Pro Gly Phe Tyr Thr Gly Glu Tyr Asp Met Pro Asp Pro Asn 1150 1155 1160 gac ggg ttc ctg tgg gac gac gtg gac agc agc gtg ttc tcg ccg 13281 Asp Gly Phe Leu Trp Asp Asp Val Asp Ser Ser Val Phe Ser Pro 1165 1170 1175 cgc ccc acc acc acc gtg tgg aag aaa gag ggc ggg gac cgg cgg 13326 Arg Pro Thr Thr Thr Val Trp Lys Lys Glu Gly Gly Asp Arg Arg 1180 1185 1190 ccg tcc tcg gcg ctg tcc ggt cgc gcg ggt gct gcc gcg gcg gtg 13371 Pro Ser Ser Ala Leu Ser Gly Arg Ala Gly Ala Ala Ala Ala Val 1195 1200 1205 ccc gag gcc gcc agc ccc ttc ccg agc ctg ccc ttt tcg ctg aac 13416 Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu Pro Phe Ser Leu Asn 1210 1215 1220 agc gtg cgc agc agc gat ctg ggt cgg ctg acg cgg ccg cgc ctg 13461 Ser Val Arg Ser Ser Asp Leu Gly Arg Leu Thr Arg Pro Arg Leu 1225 1230 1235 ctg ggc gag gag gag tac ctg aac gac tcc ttg ttg agg ccc gag 13506 Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu Arg Pro Glu 1240 1245 1250 cgc gag aaa aac ttc ccc aat aac ggg ata gag agc ctg gtg gac 13551 Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu Val Asp 1255 1260 1265 aag atg agc cgc tgg aag acg tac gcg cac gag cac agg gac gag 13596 Lys Met Ser Arg Trp Lys Thr Tyr Ala His Glu His Arg Asp Glu 1270 1275 1280 ccc cga gct agc agc agc acc ggc gcc cgt aga cgc cag cgg cac 13641 Pro Arg Ala Ser Ser Ser Thr Gly Ala Arg Arg Arg Gln Arg His 1285 1290 1295 gac agg cag cgg gga ctg gtg tgg gac gat gag gat tcc gcc gac 13686 Asp Arg Gln Arg Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp 1300 1305 1310 gac agc agc gtg ttg gac ttg ggt ggg agt ggt ggt ggt aac ccg 13731 Asp Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro 1315 1320 1325 ttc gct cac ctg cgc ccc cgt atc ggg cgc ctg atg taagaatctg 13777 Phe Ala His Leu Arg Pro Arg Ile Gly Arg Leu Met 1330 1335 1340 aaaaaataaa aaaacggtac tcaccaaggc catggcgacc agcgtgcgtt cttctctgtt 13837 gtttgtagta gt atg atg agg cgc gtg tac ccg gag ggt cct cct ccc 13885 Met Met Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro 1345 1350 tcg tac gag agc gtg atg cag cag gcg gtg gcg gcg gcg atg cag 13930 Ser Tyr Glu Ser Val Met Gln Gln Ala Val Ala Ala Ala Met Gln 1355 1360 1365 ccc ccg ctg gag gcg cct tac gtg ccc ccg cgg tac ctg gcg cct 13975 Pro Pro Leu Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro 1370 1375 1380 acg gag ggg cgg aac agc att cgt tac tcg gag ctg gca ccc ttg 14020 Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu 1385 1390 1395 tac gat acc acc cgg ttg tac ctg gtg gac aac aag tcg gcg gac 14065 Tyr Asp Thr Thr Arg Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp 1400 1405 1410 atc gcc tcg ctg aac tac cag aac gac cac agc aac ttc ctg acc 14110 Ile Ala Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr 1415 1420 1425 acc gtg gtg cag aac aac gat ttc acc ccc acg gag gcc agc acc 14155 Thr Val Val Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr 1430 1435 1440 cag acc atc aac ttt gac gag cgc tcg cgg tgg ggc ggc cag ctg 14200 Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu 1445 1450 1455 aaa acc atc atg cac acc aac atg ccc aac gtg aac gag ttc atg 14245 Lys Thr Ile Met His Thr Asn Met Pro Asn Val Asn Glu Phe Met 1460 1465 1470 tac agc aac aag ttc aag gcg cgg gtg atg gtc tcg cgc aag acc 14290 Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser Arg Lys Thr 1475 1480 1485 ccc aac ggg gtc aca gta aca gat ggt agt cag gac gag ctg acc 14335 Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln Asp Glu Leu Thr 1490 1495 1500 tac gag tgg gtg gag ttt gag ctg ccc gag ggc aac ttc tcg gtg 14380 Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn Phe Ser Val 1505 1510 1515 acc atg acc atc gat ctg atg aac aac gcc atc atc gac aac tac 14425 Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr 1520 1525 1530 ttg gcg gtg gga cgg cag aac ggg gtg ctg gag agc gac atc ggc 14470 Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly 1535 1540 1545 gtg aag ttc gac acg cgc aac ttc cgg ctg ggc tgg gac ccc gtg 14515 Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val 1550 1555 1560 acc gag ctg gtg atg ccg ggc gtg tac acc aac gag gcc ttc cac 14560 Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His 1565 1570 1575 ccc gac atc gtc ctg ctg ccc ggc tgc ggc gtg gac ttc acc gag 14605 Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu 1580 1585 1590 agc cgc ctc agc aac ctg ctg ggc atc cgc aag cgg cag ccc ttc 14650 Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe 1595 1600 1605 cag gag ggc ttc cag atc ctg tac gag gac ctg gag ggg ggc aac 14695 Gln Glu Gly Phe Gln Ile Leu Tyr Glu Asp Leu Glu Gly Gly Asn 1610 1615 1620 atc ccc gcg ctg ctg gac gtc gaa gcc tac gag aaa agc aag gag 14740 Ile Pro Ala Leu Leu Asp Val Glu Ala Tyr Glu Lys Ser Lys Glu 1625 1630 1635 gag gcc gcc gca gcg gcg acc gcg gcc gtg gct acc gct gcg acc 14785 Glu Ala Ala Ala Ala Ala Thr Ala Ala Val Ala Thr Ala Ala Thr 1640 1645 1650 acc gat gca gat gca gct act act acc agg ggc gat aca ttc gcc 14830 Thr Asp Ala Asp Ala Ala Thr Thr Thr Arg Gly Asp Thr Phe Ala 1655 1660 1665 acc cag gcg gag gaa gca gcc gcc cta gcg gcg acc gat gat agt 14875 Thr Gln Ala Glu Glu Ala Ala Ala Leu Ala Ala Thr Asp Asp Ser 1670 1675 1680 gaa agt aag ata gtc atc aag ccg gtg gag aag gac agc aag gac 14920 Glu Ser Lys Ile Val Ile Lys Pro Val Glu Lys Asp Ser Lys Asp 1685 1690 1695 agg agc tac aac gtt cta tcg gat gga aag aac acc gcc tac cgc 14965 Arg Ser Tyr Asn Val Leu Ser Asp Gly Lys Asn Thr Ala Tyr Arg 1700 1705 1710 agc tgg tac ctg gcc tac aac tac ggc gac cct gag aag ggc gtg 15010 Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly Asp Pro Glu Lys Gly Val 1715 1720 1725 cgc tcc tgg acg ctg ctc acc acc tcg gac gtc acc tgc ggc gtg 15055 Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp Val Thr Cys Gly Val 1730 1735 1740 gag caa gtc tac tgg tcg ctg ccc gac atg atg caa gac ccg gtc 15100 Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met Gln Asp Pro Val 1745 1750 1755 acc ttc cgc tcc acg cgt caa gtt agc aac tac ccg gtg gtg ggc 15145 Thr Phe Arg Ser Thr Arg Gln Val Ser Asn Tyr Pro Val Val Gly 1760 1765 1770 gcc gag ctc ctg ccc gtc tac tcc aag agc ttc ttc aac gag cag 15190 Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser Phe Phe Asn Glu Gln 1775 1780 1785 gcc gtc tac tcg cag cag ctg cgc gcc ttc acc tcg ctc acg cac 15235 Ala Val Tyr Ser Gln Gln Leu Arg Ala Phe Thr Ser Leu Thr His 1790 1795 1800 gtc ttc aac cgc ttc ccc gag aac cag atc ctc gtc cgc ccg ccc 15280 Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Val Arg Pro Pro 1805 1810 1815 gcg ccc acc att acc acc gtc agt gaa aac gtt cct gct ctc aca 15325 Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr 1820 1825 1830 gat cac ggg acc ctg ccg ctg cgc agc agt atc cgg gga gtc cag 15370 Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln 1835 1840 1845 cgc gtg acc gtc act gac gcc aga cgc cgc acc tgc ccc tac gtc 15415 Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val 1850 1855 1860 tac aag gcc ctg ggc gta gtc gcg ccg cgc gtc ctc tcg agc cgc 15460 Tyr Lys Ala Leu Gly Val Val Ala Pro Arg Val Leu Ser Ser Arg 1865 1870 1875 acc ttc taaaaa atg tcc att ctc atc tcg ccc agt aat aac acc ggt 15508 Thr Phe Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly 1880 1885 1890 tgg ggc ctg cgc gcg ccc agc aag atg tac gga ggc gct cgc caa 15553 Trp Gly Leu Arg Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln 1895 1900 1905 cgc tcc acg caa cac ccc gtg cgc gtg cgc ggg cac ttc cgc gct 15598 Arg Ser Thr Gln His Pro Val Arg Val Arg Gly His Phe Arg Ala 1910 1915 1920 ccc tgg ggc gcc ctc aag ggc cgc gtg cgc tcg cgc acc acc gtc 15643 Pro Trp Gly Ala Leu Lys Gly Arg Val Arg Ser Arg Thr Thr Val 1925 1930 1935 gac gac gtg atc gac cag gtg gtg gcc gac gcg cgc aac tac acg 15688 Asp Asp Val Ile Asp Gln Val Val Ala Asp Ala Arg Asn Tyr Thr 1940 1945 1950 ccc gcc gcc gcg ccc gcc tcc acc gtg gac gcc gtc atc gac agc 15733 Pro Ala Ala Ala Pro Ala Ser Thr Val Asp Ala Val Ile Asp Ser 1955 1960 1965 gtg gtg gcc gac gcg cgc cgg tac gcc cgc gcc aag agc cgg cgg 15778 Val Val Ala Asp Ala Arg Arg Tyr Ala Arg Ala Lys Ser Arg Arg 1970 1975 1980 cgg cgc atc gcc cgg cgg cac cgg agc acc ccc gcc atg cgc gcg 15823 Arg Arg Ile Ala Arg Arg His Arg Ser Thr Pro Ala Met Arg Ala 1985 1990 1995 gcg cga gcc ttg ctg cgc agg gcc agg cgc acg gga cgc agg gcc 15868 Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr Gly Arg Arg Ala 2000 2005 2010 atg ctc agg gcg gcc aga cgc gcg gcc tcc ggc agc agc agc gcc 15913 Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ser Ser Ser Ala 2015 2020 2025 ggc agg acc cgc aga cgc gcg gcc acg gcg gcg gcg gcg gcc atc 15958 Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala Ala Ile 2030 2035 2040 gcc agc atg tcc cgc ccg cgg cgc ggc aac gtg tac tgg gtg cgc 16003 Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val Arg 2045 2050 2055 gac gcc gcc acc ggt gtg cgc gtg ccc gtg cgc acc cgc ccc cct 16048 Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro 2060 2065 2070 cgc act tgaagatgct gacttcgcga tgttgatgtg tcccagcggc gaggagg atg 16104 Arg Thr Met 2075 tcc aag cgc aaa ttc aag gaa gag atg ctc cag gtc atc gcg cct 16149 Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 2080 2085 2090 gag atc tac ggc ccc gcg gcg gcg gtg aag gag gaa aga aag ccc 16194 Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys Glu Glu Arg Lys Pro 2095 2100 2105 cgc aaa ctg aag cgg gtc aaa aag gac aaa aag gag gag gaa gat 16239 Arg Lys Leu Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Glu Asp 2110 2115 2120 gac gga ctg gtg gag ttt gtg cgc gag ttc gcc ccc cgg cgg cgc 16284 Asp Gly Leu Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg 2125 2130 2135 gtg cag tgg cgc ggg cgg aaa gtg aaa ccg gtg ctg cgg ccc ggc 16329 Val Gln Trp Arg Gly Arg Lys Val Lys Pro Val Leu Arg Pro Gly 2140 2145 2150 acc acg gtg gtc ttc acg ccc ggc gag cgt tcc ggc tcc gcc tcc 16374 Thr Thr Val Val Phe Thr Pro Gly Glu Arg Ser Gly Ser Ala Ser 2155 2160 2165 aag cgc tcc tac gac gag gtg tac ggg gac gag gac atc ctc gag 16419 Lys Arg Ser Tyr Asp Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu 2170 2175 2180 cag gcg gca gag cgt ctg ggc gag ttt gct tac ggc aag cgc agc 16464 Gln Ala Ala Glu Arg Leu Gly Glu Phe Ala Tyr Gly Lys Arg Ser 2185 2190 2195 cgc ccc gcg ccc ttg aaa gag gag gcg gtg tcc atc ccg ctg gac 16509 Arg Pro Ala Pro Leu Lys Glu Glu Ala Val Ser Ile Pro Leu Asp 2200 2205 2210 cac ggc aac ccc acg ccg agc ctg aag ccg gtg acc ctg cag cag 16554 His Gly Asn Pro Thr Pro Ser Leu Lys Pro Val Thr Leu Gln Gln 2215 2220 2225 gtg ctg ccg agc gcg gcg ccg cgc cgg ggc ttc aag cgc gag ggc 16599 Val Leu Pro Ser Ala Ala Pro Arg Arg Gly Phe Lys Arg Glu Gly 2230 2235 2240 ggc gag gat ctg tac ccg acc atg cag ctg atg gtg ccc aag cgc 16644 Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met Val Pro Lys Arg 2245 2250 2255 cag aag ctg gag gac gtg ctg gag cac atg aag gtg gac ccc gag 16689 Gln Lys Leu Glu Asp Val Leu Glu His Met Lys Val Asp Pro Glu 2260 2265 2270 gtg cag ccc gag gtc aag gtg cgg ccc atc aag cag gtg gcc ccg 16734 Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln Val Ala Pro 2275 2280 2285 ggc ctg ggc gtg cag acc gtg gac atc aag atc ccc acg gag ccc 16779 Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr Glu Pro 2290 2295 2300 atg gaa acg cag acc gag ccc gtg aag ccc agc acc agc acc atg 16824 Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr Met 2305 2310 2315 gag gtg cag acg gat ccc tgg atg ccg gcg ccg gct tcc acc acc 16869 Glu Val Gln Thr Asp Pro Trp Met Pro Ala Pro Ala Ser Thr Thr 2320 2325 2330 act cgc cga aga cgc aag tac ggc gcg gcc agc ctg ctg atg ccc 16914 Thr Arg Arg Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro 2335 2340 2345 aac tac gcg ctg cat cct tcc atc atc ccc acg ccg ggc tac cgc 16959 Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg 2350 2355 2360 ggc acg cgc ttc tac cgc ggc tac agc agc cgc cgc aag acc acc 17004 Gly Thr Arg Phe Tyr Arg Gly Tyr Ser Ser Arg Arg Lys Thr Thr 2365 2370 2375 acc cgc cgc cgc cgt cgc cgc acc cgc cgc agc acc acc gcg act 17049 Thr Arg Arg Arg Arg Arg Arg Thr Arg Arg Ser Thr Thr Ala Thr 2380 2385 2390 tcc gcc gcc gcc ttg gtg cgg aga gtg tac cgc agc ggg cgt gag 17094 Ser Ala Ala Ala Leu Val Arg Arg Val Tyr Arg Ser Gly Arg Glu 2395 2400 2405 cct ctg acc ctg ccg cgc gcg cgc tac cac ccg agc atc gcc att 17139 Pro Leu Thr Leu Pro Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 2410 2415 2420 taactctgcc gtcgcctcct tgcagat atg gcc ctc aca tgc cgc ctc cgc 17190 Met Ala Leu Thr Cys Arg Leu Arg 2425 gtc ccc att acg ggc tac cga gga aga aag ccg cgc cgt aga agg 17235 Val Pro Ile Thr Gly Tyr Arg Gly Arg Lys Pro Arg Arg Arg Arg 2430 2435 2440 ctg acg ggg aac ggg ctg cgt cgc cat cac cac cgg cgg cgg cgc 17280 Leu Thr Gly Asn Gly Leu Arg Arg His His His Arg Arg Arg Arg 2445 2450 2455 gcc atc agc aag cgg ttg ggg gga ggc ttc ctg ccc gcg ctg atc 17325 Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe Leu Pro Ala Leu Ile 2460 2465 2470 ccc atc atc gcc gcg gcg atc ggg gcg atc ccc ggc ata gct tcc 17370 Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro Gly Ile Ala Ser 2475 2480 2485 gtg gcg gtg cag gcc tct cag cgc cac tgagacacag cttggaaaat 17417 Val Ala Val Gln Ala Ser Gln Arg His 2490 2495 ttgtaataaa aaaatggact gacgctcctg gtcctgtgat gtgtgttttt ag atg gaa 17475 Met Glu gac atc aat ttt tcg tcc ctg gca ccg cga cac ggc acg cgg ccg 17520 Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg Pro 2500 2505 2510 ttt atg ggc acc tgg agc gac atc ggc aac agc caa ctg aac ggg 17565 Phe Met Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly 2515 2520 2525 ggc gcc ttc aat tgg agc agt ctc tgg agc ggg ctt aag aat ttc 17610 Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe 2530 2535 2540 ggg tcc acg ctc aaa acc tat ggc aac aag gcg tgg aac agc agc 17655 Gly Ser Thr Leu Lys Thr Tyr Gly Asn Lys Ala Trp Asn Ser Ser 2545 2550 2555 aca ggg cag gcg ctg agg gaa aag ctg aaa gag cag aac ttc cag 17700 Thr Gly Gln Ala Leu Arg Glu Lys Leu Lys Glu Gln Asn Phe Gln 2560 2565 2570 cag aag gtg gtc gat ggc ctg gcc tcg ggc atc aac ggg gtg gtg 17745 Gln Lys Val Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val 2575 2580 2585 gac ctg gcc aac cag gcc gtg cag aaa cag atc aac agc cgc ctg 17790 Asp Leu Ala Asn Gln Ala Val Gln Lys Gln Ile Asn Ser Arg Leu 2590 2595 2600 gac gcg gtc ccg ccc gcg ggg tcc gtg gag atg ccc cag gtg gag 17835 Asp Ala Val Pro Pro Ala Gly Ser Val Glu Met Pro Gln Val Glu 2605 2610 2615 gag gag ctg cct ccc ctg gac aag cgc ggc gac aag cga ccg cgt 17880 Glu Glu Leu Pro Pro Leu Asp Lys Arg Gly Asp Lys Arg Pro Arg 2620 2625 2630 ccc gac gcg gag gag acg ctg ctg acg cac acg gac gag ccg ccc 17925 Pro Asp Ala Glu Glu Thr Leu Leu Thr His Thr Asp Glu Pro Pro 2635 2640 2645 ccg tac gag gag gcg gtg aaa ctg ggt ctg ccc acc acg cgg ccc 17970 Pro Tyr Glu Glu Ala Val Lys Leu Gly Leu Pro Thr Thr Arg Pro 2650 2655 2660 atc gcg ccc ctg gcc acc ggg gtg ctg aaa ccc gag tct aag ccc 18015 Ile Ala Pro Leu Ala Thr Gly Val Leu Lys Pro Glu Ser Lys Pro 2665 2670 2675 gcg acc ctg gac ttg cct cct ccc ccg acc tcc cgc ccc tcc aca 18060 Ala Thr Leu Asp Leu Pro Pro Pro Pro Thr Ser Arg Pro Ser Thr 2680 2685 2690 gtg gct aag ccc ctg ccg ccg gtg gcc cgc gcg cga ccc ggg agc 18105 Val Ala Lys Pro Leu Pro Pro Val Ala Arg Ala Arg Pro Gly Ser 2695 2700 2705 cgc ccg cag gcg aac tgg cag agc act ctg aac agc atc gtg ggt 18150 Arg Pro Gln Ala Asn Trp Gln Ser Thr Leu Asn Ser Ile Val Gly 2710 2715 2720 ctg gga gtg cag agt gtg aag cgc cgc cgc tgc tat taaacatacc 18196 Leu Gly Val Gln Ser Val Lys Arg Arg Arg Cys Tyr 2725 2730 2735 gtagcgctta acttgcttgt ctgtgtgtgt atgtattatg tcgccgccgc tgtccagaag 18256 gaggagtgaa gaggcgcgtc gccgagttgc aag atg gcc acc cca tcg atg ctg 18310 Met Ala Thr Pro Ser Met Leu 2740 ccc cag tgg gcg tac atg cac atc gcc gga cag gac gct tcg gag 18355 Pro Gln Trp Ala Tyr Met His Ile Ala Gly Gln Asp Ala Ser Glu 2745 2750 2755 tac ctg agt ccg ggt ctg gtg cag ttc gcc cgc gcc aca gac acc 18400 Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala Arg Ala Thr Asp Thr 2760 2765 2770 tac ttc agt ctg ggg aac aag ttt agg aac ccc acg gtg gcg ccc 18445 Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro Thr Val Ala Pro 2775 2780 2785 acg cac gat gtg acc acc gac cgc agc cag cgg ctg acg ctg cgc 18490 Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu Thr Leu Arg 2790 2795 2800 ttc gtg ccc gtg gac cgc gag gac aac acc tac tcg tac aaa gtg 18535 Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr Lys Val 2805 2810 2815 cgc tac acg ctg gcc gtg ggc gac aac cgc gtg ctg gac atg gcc 18580 Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met Ala 2820 2825 2830 agc acc tac ttt gac atc cgc ggc gtg ctg gac cgg ggc cct agc 18625 Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 2835 2840 2845 ttc aaa ccc tac tcc ggc acc gcc tac aac agc ctg gcc ccc aag 18670 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys 2850 2855 2860 gga gct ccc aat tcc agt cag tgg gag cag acg gag aac ggg ggc 18715 Gly Ala Pro Asn Ser Ser Gln Trp Glu Gln Thr Glu Asn Gly Gly 2865 2870 2875 gga cag gct acg act aaa aca cac acc tat gga gtt gcc cca atg 18760 Gly Gln Ala Thr Thr Lys Thr His Thr Tyr Gly Val Ala Pro Met 2880 2885 2890 ggt gga act aat att aca gtc gac gga cta caa att gga act gac 18805 Gly Gly Thr Asn Ile Thr Val Asp Gly Leu Gln Ile Gly Thr Asp 2895 2900 2905 gct aca gct gat acg gaa aaa cca att tat gct gat aaa aca ttc 18850 Ala Thr Ala Asp Thr Glu Lys Pro Ile Tyr Ala Asp Lys Thr Phe 2910 2915 2920 caa cct gag cct cag ata gga gag gaa aac tgg caa gaa act gaa 18895 Gln Pro Glu Pro Gln Ile Gly Glu Glu Asn Trp Gln Glu Thr Glu 2925 2930 2935 agc ttt tat ggc ggt agg gct ctt aag aaa gac aca aac atg aag 18940 Ser Phe Tyr Gly Gly Arg Ala Leu Lys Lys Asp Thr Asn Met Lys 2940 2945 2950 cct tgt tat ggc tca ttt gcc aga cct acc aat gaa aag gga ggt 18985 Pro Cys Tyr Gly Ser Phe Ala Arg Pro Thr Asn Glu Lys Gly Gly 2955 2960 2965 caa gct aaa ctt aaa gtt gga gct gat ggg ctg ccg acc aaa gaa 19030 Gln Ala Lys Leu Lys Val Gly Ala Asp Gly Leu Pro Thr Lys Glu 2970 2975 2980 ttt gac ata gac cta gca ttc ttt gat act cct ggt ggc act gtg 19075 Phe Asp Ile Asp Leu Ala Phe Phe Asp Thr Pro Gly Gly Thr Val 2985 2990 2995 acc gga ggt aca gag gag tat aaa gca gat att gtt atg tat acc 19120 Thr Gly Gly Thr Glu Glu Tyr Lys Ala Asp Ile Val Met Tyr Thr 3000 3005 3010 gaa aac acg tat ctg gaa act cca gac aca cat gtg gtg tat aaa 19165 Glu Asn Thr Tyr Leu Glu Thr Pro Asp Thr His Val Val Tyr Lys 3015 3020 3025 cca ggc aag gat aac aca agt tct aaa att aac ctg gtc cag cag 19210 Pro Gly Lys Asp Asn Thr Ser Ser Lys Ile Asn Leu Val Gln Gln 3030 3035 3040 tct atg ccc aac agg ccc aac tac att ggg ttt agg gac aac ttt 19255 Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe 3045 3050 3055 att ggg ctc atg tat tac aac agc act ggc aat atg ggt gtg ctg 19300 Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu 3060 3065 3070 gcc ggt cag gct tct cag ttg aat gct gtg gtt gac ttg caa gac 19345 Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp 3075 3080 3085 aga aac act gaa ctg tct tac cag ctc ttg ctt gac tct ttg ggt 19390 Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly 3090 3095 3100 gac aga acc agg tat ttc agt atg tgg aat cag gcg gtg gac agt 19435 Asp Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser 3105 3110 3115 tat gat cct gat gtg cgc att att gaa aac cat ggt gtg gaa gat 19480 Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp 3120 3125 3130 gaa ctt ccc aac tat tgc ttc ccc ctg gat ggg tct ggc act aac 19525 Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asp Gly Ser Gly Thr Asn 3135 3140 3145 gcc gct tac caa ggt gtg aaa gta aaa aat ggt caa gat ggt gat 19570 Ala Ala Tyr Gln Gly Val Lys Val Lys Asn Gly Gln Asp Gly Asp 3150 3155 3160 gtt gag agc gaa tgg gaa aaa gat gat act gtc gca gct cga aat 19615 Val Glu Ser Glu Trp Glu Lys Asp Asp Thr Val Ala Ala Arg Asn 3165 3170 3175 caa tta tgc aag ggc aac att ttt gcc atg gag atc aat ctc cag 19660 Gln Leu Cys Lys Gly Asn Ile Phe Ala Met Glu Ile Asn Leu Gln 3180 3185 3190 gcc aac ctg tgg aga agt ttt ctc tac tcg aac gtg gcc ctg tac 19705 Ala Asn Leu Trp Arg Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr 3195 3200 3205 ctg ccc gat tct tac aag tac acg ccg gcc aac atc acc ctg ccc 19750 Leu Pro Asp Ser Tyr Lys Tyr Thr Pro Ala Asn Ile Thr Leu Pro 3210 3215 3220 acc aac acc aac acc tac gat tac atg aac ggg aga gtg gtg cct 19795 Thr Asn Thr Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val Val Pro 3225 3230 3235 ccc tcg ctg gtg gac gcc tac atc aac atc ggg gcg cgc tgg tcg 19840 Pro Ser Leu Val Asp Ala Tyr Ile Asn Ile Gly Ala Arg Trp Ser 3240 3245 3250 ctg gac ccc atg gac aac gtc aat ccc ttc aac cac cat cgc aac 19885 Leu Asp Pro Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn 3255 3260 3265 gcg ggg ctg cgc tac cgc tcc atg ctc ctg ggc aac ggg cgc tac 19930 Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr 3270 3275 3280 gtg ccc ttc cac atc cag gtg ccc cag aaa ttt ttc gcc att aag 19975 Val Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys 3285 3290 3295 agc ctc ctg ctc ctg ccc ggg tcc tac acc tac gag tgg aac ttc 20020 Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe 3300 3305 3310 cgc aag gac gtc aac atg atc ctg cag agc tcc ctc ggc aac gac 20065 Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp 3315 3320 3325 ctg cgc acg gac ggg gcc tcc atc tcc ttc acc agc atc aac ctc 20110 Leu Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu 3330 3335 3340 tac gcc acc ttc ttc ccc atg gcg cac aac acc gcc tcc acg ctc 20155 Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu 3345 3350 3355 gag gcc atg ctg cgc aac gac acc aac gac cag tcc ttc aac gac 20200 Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp 3360 3365 3370 tac ctc tcg gcg gcc aac atg ctc tac ccc atc ccg gcc aac gcc 20245 Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala 3375 3380 3385 acc aac gtg ccc atc tcc atc ccc tcg cgc aac tgg gcc gcc ttc 20290 Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe 3390 3395 3400 cgc ggc tgg tcc ttc acg cgc ctc aag acc aag gag acg ccc tcg 20335 Arg Gly Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser 3405 3410 3415 ctg ggc tcc ggg ttc gac ccc tac ttc gtc tac tcg ggc tcc atc 20380 Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile 3420 3425 3430 ccc tac ctc gac ggc acc ttc tac ctc aac cac acc ttc aag aag 20425 Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys 3435 3440 3445 gtc tcc atc acc ttc gac tcc tcc gtc agc tgg ccc ggc aac gac 20470 Val Ser Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp 3450 3455 3460 cgg ctc ctg acg ccc aac gag ttc gaa atc aag cgc acc gtc gac 20515 Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp 3465 3470 3475 ggc gag ggc tac aac gtg gcc cag tgc aac atg acc aag gac tgg 20560 Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp 3480 3485 3490 ttc ctg gtc cag atg ctg gcc cac tac aac atc ggc tac cag ggc 20605 Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly 3495 3500 3505 ttc tac gtg ccc gag ggc tac aag gac cgc atg tac tcc ttc ttc 20650 Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe 3510 3515 3520 cgc aac ttc cag ccc atg agc cgc cag gtg gtg gac gag gtc aac 20695 Arg Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Val Asn 3525 3530 3535 tac aag gac tac cag gcc gtc acc ctg gcc tac cag cac aac aac 20740 Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn Asn 3540 3545 3550 tcg ggc ttc gtc ggc tac ctc gcg ccc acc atg cgc cag ggc cag 20785 Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln 3555 3560 3565 ccc tac ccc gcc aac tac ccg tac ccg ctc atc ggc aag agc gcc 20830 Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala 3570 3575 3580 gtc acc agc gtc acc cag aaa aag ttc ctc tgc gac agg gtc atg 20875 Val Thr Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met 3585 3590 3595 tgg cgc atc ccc ttc tcc agc aac ttc atg tcc atg ggc gcg ctc 20920 Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu 3600 3605 3610 acc gac ctc ggc cag aac atg ctc tat gcc aac tcc gcc cac gcg 20965 Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala 3615 3620 3625 cta gac atg aat ttc gaa gtc gac ccc atg gat gag tcc acc ctt 21010 Leu Asp Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu 3630 3635 3640 ctc tat gtt gtc ttc gaa gtc ttc gac gtc gtc cga gtg cac cag 21055 Leu Tyr Val Val Phe Glu Val Phe Asp Val Val Arg Val His Gln 3645 3650 3655 ccc cac cgc ggc gtc atc gag gcc gtc tac ctg cgc acc ccc ttc 21100 Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe 3660 3665 3670 tcg gcc ggt aac gcc acc acc taagctcttg cttcttgcaa g atg gct gag 21151 Ser Ala Gly Asn Ala Thr Thr Met Ala Glu 3675 3680 ccc acg ggc tcc ggc gag cag gag ctc agg gcc atc atc cgc gac 21196 Pro Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile Arg Asp 3685 3690 3695 ctg ggc tgc ggg ccc tac ttc ctg ggc acc ttc gat aag cgc ttc 21241 Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg Phe 3700 3705 3710 ccg gga ttc atg gcc ccg cac aag ctg gcc tgc gcc atc gtc aac 21286 Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn 3715 3720 3725 acg gcc ggc cgc gag acc ggg ggc gag cac tgg ctg gcc ttc gcc 21331 Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala 3730 3735 3740 tgg aac ccg cgc tcg aac acc tgc tac ctc ttc gac ccc ttc ggg 21376 Trp Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly 3745 3750 3755 ttc tcg gac gag cgc ctc aag cag atc tac cag ttc gag tac gag 21421 Phe Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu 3760 3765 3770 ggc ctg ctg cgc cgc agc gcc ctg gcc acc gag gac cgc tgc gtc 21466 Gly Leu Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val 3775 3780 3785 acc ctg gaa aag tcc acc cag acc gtg cag ggt ccg cgc tcg gcc 21511 Thr Leu Glu Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala 3790 3795 3800 gcc tgc ggg ctc ttt tgc tgc atg ttc ctg cac gcc ttc gtg cac 21556 Ala Cys Gly Leu Phe Cys Cys Met Phe Leu His Ala Phe Val His 3805 3810 3815 tgg ccc gac cgc ccc atg gac aag aac ccc acc atg aac ttg ctg 21601 Trp Pro Asp Arg Pro Met Asp Lys Asn Pro Thr Met Asn Leu Leu 3820 3825 3830 acg ggg gtg ccc aac ggc atg ctc cag tcg ccc cag gtg gaa ccc 21646 Thr Gly Val Pro Asn Gly Met Leu Gln Ser Pro Gln Val Glu Pro 3835 3840 3845 acc ctg cgc cgc aac cag gag gcg ctc tac cgc ttc ctc aac gcc 21691 Thr Leu Arg Arg Asn Gln Glu Ala Leu Tyr Arg Phe Leu Asn Ala 3850 3855 3860 cac tcc gcc tac ttt cgc tcc cac cgc gcg cgc atc gag aag gcc 21736 His Ser Ala Tyr Phe Arg Ser His Arg Ala Arg Ile Glu Lys Ala 3865 3870 3875 acc gcc ttc gac cgc atg aat caa gac atg taaaccgtgt gtgtgtatgt 21786 Thr Ala Phe Asp Arg Met Asn Gln Asp Met 3880 3885 taaaatgtct ttaataaaca gcactttcat gttacacatg catctgagat gatttattta 21846 gaaatcgaaa gggttctgcc gggtctcggc atggcccgcg ggcagggaca cgttgcggaa 21906 ctggtacttg gccagccact tgaactcggg gatcagcagt ttcggcagcg gggtgtcggg 21966 gaaggagtcg gtccacagct tccgcgtcag ttgcagggcg cccagcaggt cgggcgcgga 22026 gatcttgaaa tcgcagttgg gacccgcgtt ctgcgcgcga gagttgcggt acacggggtt 22086 gcagcactgg aacaccatca gggccgggtg cttcacgctc gccagcaccg tcgcgtcggt 22146 gatgccctcc acgtccagat cctcggcgtt ggccatcccg aagggggtca tcttgcaggt 22206 ctgccgcccc atgctgggca cgcagccggg cttgtggttg caatcgcagt gcagggggat 22266 cagcatcatc tgggcctgct cggagctcat gcccgggtac atggccttca tgaaagcctc 22326 cagctggcgg aaggcctgct gcgccttgcc gccctcggtg aagaagaccc cgcaggactt 22386 gctagagaac tggttggtag cgcagcccgc gtcgtgcacg cagcagcgcg cgtcgttgtt 22446 ggccagctgc accacgctgc gcccccagcg gttctgggtg atcttggccc ggtcggggtt 22506 ctccttcagc gcgcgctgcc cgttctcgct cgccacatcc atctcgatcg tgtgctcctt 22566 ctggatcatc acggtcccgt gcaggcaccg cagcttgccc tcggcctcgg tgcagccgtg 22626 cagccacagc gcgcagccgg tgctctccca gttcttgtgg gcgatctggg agtgcgagtg 22686 cacgaagccc tgcaggaagc ggcccatcat cgcggtcagg gtcttgttgc tggtgaaggt 22746 cagcgggatg ccgcggtgct cctcgttcac atacaggtgg cagatgcggc ggtacacctc 22806 gccctgctcg ggcatcagct ggaaggcgga cttcaggtcg ctctccacgc ggtaccggtc 22866 catcagcagc gtcatcactt ccatgccctt ctcccaggcc gagacgatcg gcaggctcag 22926 ggggttcttc accgccattg tcatcttagt cgccgccgcc gaggtcaggg ggtcgttctc 22986 gtccagggtc tcaaacactc gcttgccgtc cttctcgatg atgcgcacgg ggggaaagct 23046 gaagcccacg gccgccagct cctcctcggc ctgcctttcg tcctcgctgt cctggctgat 23106 gtcttgcaaa ggcacatgct tggtcttgcg gggtttcttt ttgggcggca gaggcggcgg 23166 cgatgtgctg ggcgagcgcg agttctcgct caccacgact atttcttctc cttggccgtc 23226 gtccgagacc acgcggcggt aggcatgcct cttctggggc agaggcggag gcgacgggct 23286 ctcgcggttc ggcgggcggc tggcagagcc ccttccgcgt tcgggggtgc gctcctggcg 23346 gcgctgctct gactgacttc ctccgcggcc ggccattgtg ttctcctagg gagcaacaac 23406 aagc atg gag act cag cca tcg tcg cca aca tcg cca tct gcc ccc 23452 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro 3890 3895 3900 gcc tcc acc gcc gac gag aac cag cag cag aat gaa agc tta acc 23497 Ala Ser Thr Ala Asp Glu Asn Gln Gln Gln Asn Glu Ser Leu Thr 3905 3910 3915 gcc ccg ccg ccc agc ccc acc tcc gac gcc gcg gcc cca gac atg 23542 Ala Pro Pro Pro Ser Pro Thr Ser Asp Ala Ala Ala Pro Asp Met 3920 3925 3930 caa gag atg gag gaa tcc atc gag att gac ctg ggc tac gtg acg 23587 Gln Glu Met Glu Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr 3935 3940 3945 ccc gcg gag cac gag gag gag ctg gca gcg cgc ttt tca gcc ccg 23632 Pro Ala Glu His Glu Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro 3950 3955 3960 gaa gag aac cac caa gag cag cca gag cag gaa gca gag aac gag 23677 Glu Glu Asn His Gln Glu Gln Pro Glu Gln Glu Ala Glu Asn Glu 3965 3970 3975 cag aac cag gct ggg cac gag cat ggc gac tac ctg agc ggg gca 23722 Gln Asn Gln Ala Gly His Glu His Gly Asp Tyr Leu Ser Gly Ala 3980 3985 3990 gag gac gtg ctc atc aag cat ctg gcc cgc caa tgc atc atc gtc 23767 Glu Asp Val Leu Ile Lys His Leu Ala Arg Gln Cys Ile Ile Val 3995 4000 4005 aag gac gcg ctg ctc gac cgc gcc gag gtg ccc ctc agc gtg gcg 23812 Lys Asp Ala Leu Leu Asp Arg Ala Glu Val Pro Leu Ser Val Ala 4010 4015 4020 gag ctc agc cgc gcc tac gag cgc aac ctc ttc tcg ccg cgc gtg 23857 Glu Leu Ser Arg Ala Tyr Glu Arg Asn Leu Phe Ser Pro Arg Val 4025 4030 4035 ccc ccc aag cgc cag ccc aac ggc acc tgt gag ccc aac ccg cgc 23902 Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys Glu Pro Asn Pro Arg 4040 4045 4050 ctc aac ttc tac ccg gtc ttc gcg gtg ccc gag gcc ctg gcc acc 23947 Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu Ala Leu Ala Thr 4055 4060 4065 tac cac ctc ttt ttc aag aac caa aga atc ccc gtc tcc tgc cgc 23992 Tyr His Leu Phe Phe Lys Asn Gln Arg Ile Pro Val Ser Cys Arg 4070 4075 4080 gcc aac cgc acc cgc gcc gac gcc ctt ttc aac ctg ggc ccc ggc 24037 Ala Asn Arg Thr Arg Ala Asp Ala Leu Phe Asn Leu Gly Pro Gly 4085 4090 4095 gcc cgc cta cct gat atc gcc tcc ttg gaa gag gtt ccc aag atc 24082 Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro Lys Ile 4100 4105 4110 ttc gag ggt ctg ggc agc gac gag act cgg gcc gcg aac gct ctg 24127 Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu 4115 4120 4125 caa gga gaa gga gga gag cat gag cac cac agc gcc ctg gtc gag 24172 Gln Gly Glu Gly Gly Glu His Glu His His Ser Ala Leu Val Glu 4130 4135 4140 ttg gaa ggc gac aac gcg cgg ctg gcg gtg ctc aaa cgc acg gtc 24217 Leu Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val 4145 4150 4155 gag ctg acc cat ttc gcc tac ccg gct ctg aac ctg ccc ccc aaa 24262 Glu Leu Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys 4160 4165 4170 gtc atg agc gcc gtc atg gac cag gtg ctc atc aag cgc gcg tcg 24307 Val Met Ser Ala Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser 4175 4180 4185 ccc atc tcc gag gac gag ggc atg caa gac ccc gag agc acc gag 24352 Pro Ile Ser Glu Asp Glu Gly Met Gln Asp Pro Glu Ser Thr Glu 4190 4195 4200 gat ggc aag ccc gtg gtc agc gac gag cag ctg gcc cgg tgg ctg 24397 Asp Gly Lys Pro Val Val Ser Asp Glu Gln Leu Ala Arg Trp Leu 4205 4210 4215 ggt cct aat gct agt ccc cag agt ttg gaa gag cgg cgc aag ctc 24442 Gly Pro Asn Ala Ser Pro Gln Ser Leu Glu Glu Arg Arg Lys Leu 4220 4225 4230 atg atg gcc gtg gtc ctg gtg acc gtg gag ctg gag tgc ctg cgc 24487 Met Met Ala Val Val Leu Val Thr Val Glu Leu Glu Cys Leu Arg 4235 4240 4245 cgc ttc ttc gcc gac gcg gag acc ctg cgc aag gtc gag gag aac 24532 Arg Phe Phe Ala Asp Ala Glu Thr Leu Arg Lys Val Glu Glu Asn 4250 4255 4260 ctg cac tac ctc ttc agg cac ggg ttc gtg cgc cag gcc tgc aag 24577 Leu His Tyr Leu Phe Arg His Gly Phe Val Arg Gln Ala Cys Lys 4265 4270 4275 atc tcc aac gtg gag ctg acc aac ctg gtc tcc tac atg ggc atc 24622 Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr Met Gly Ile 4280 4285 4290 ttg cac gag aac cgt ctg ggg cag aac gtg ctg cac acc acc ctg 24667 Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr Thr Leu 4295 4300 4305 cgc ggg gag gcc cgc cgc gac tac atc cgc gac tgc gtc tac ctc 24712 Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr Leu 4310 4315 4320 tac ctc tgc cac acc tgg cag acg ggc atg ggc gtg tgg cag cag 24757 Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln Gln 4325 4330 4335 tgc ctg gag gag cag aac ctg aaa gag ctc tgc aag ctc ctg cag 24802 Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln 4340 4345 4350 aag aac ctc aag ggt ctg tgg acc ggg ttc gac gag cgg acc acc 24847 Lys Asn Leu Lys Gly Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr 4355 4360 4365 gcc tcg gat ctg gcc gac ctc atc ttc ccc gag cgc ctc agg ctg 24892 Ala Ser Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu 4370 4375 4380 acg ctg cgc aac ggc ctg ccc gac ttt atg agc caa agc atg ttg 24937 Thr Leu Arg Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu 4385 4390 4395 caa aac ttt cgc tct ttc atc ctc gaa cgc tcc gga atc ctg ccc 24982 Gln Asn Phe Arg Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro 4400 4405 4410 gcc acc tgc tcc gcg ctg ccc tcg gac ttc gtg ccg ctg acc ttc 25027 Ala Thr Cys Ser Ala Leu Pro Ser Asp Phe Val Pro Leu Thr Phe 4415 4420 4425 cgc gag tgc ccc ccg ccg ctg tgg agc cac tgc tac ctg ctg cgc 25072 Arg Glu Cys Pro Pro Pro Leu Trp Ser His Cys Tyr Leu Leu Arg 4430 4435 4440 ctg gcc aac tac ctg gcc tac cac tcg gac gtg atc gag gac gtc 25117 Leu Ala Asn Tyr Leu Ala Tyr His Ser Asp Val Ile Glu Asp Val 4445 4450 4455 agc ggc gag ggc ctg ctc gag tgc cac tgc cgc tgc aac ctc tgc 25162 Ser Gly Glu Gly Leu Leu Glu Cys His Cys Arg Cys Asn Leu Cys 4460 4465 4470 acg ccg cac cgc tcc ctg gcc tgc aac ccc cag ctg ctg agc gag 25207 Thr Pro His Arg Ser Leu Ala Cys Asn Pro Gln Leu Leu Ser Glu 4475 4480 4485 acc cag atc atc ggc acc ttc gag ttg caa ggg ccc agc gat gag 25252 Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln Gly Pro Ser Asp Glu 4490 4495 4500 ggt tcc gcc gcc aag ggg ggt ctg aaa ctc acc ccg ggg ctg tgg 25297 Gly Ser Ala Ala Lys Gly Gly Leu Lys Leu Thr Pro Gly Leu Trp 4505 4510 4515 acc tcg gcc tac ttg cgc aag ttc gtg ccc gag gac tac cat ccc 25342 Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr His Pro 4520 4525 4530 ttc gag atc agg ttc tac gag gac caa tcc cag ccg ccc aag gcc 25387 Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys Ala 4535 4540 4545 gag ctg tcg gcc tgc gtc atc acc cag ggg gcg atc ctg gcc caa 25432 Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala Gln 4550 4555 4560 ttg caa gcc atc cag aaa tcc cgc caa gaa ttc ttg ctg aaa aag 25477 Leu Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys 4565 4570 4575 ggc cgc ggg gtc tac ctc gac ccc cag acc ggt gag gag ctc aac 25522 Gly Arg Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn 4580 4585 4590 ccc ggc ttc ccc cag gat gcc ccg agg aaa caa gaa gct gaa agt 25567 Pro Gly Phe Pro Gln Asp Ala Pro Arg Lys Gln Glu Ala Glu Ser 4595 4600 4605 gga gct gcc gcc cgt gga gga ttt gga gga aga ctg gga gaa cag 25612 Gly Ala Ala Ala Arg Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln 4610 4615 4620 cag tca ggc aga gga gga gga gat gga gga aga ctg gga cag cac 25657 Gln Ser Gly Arg Gly Gly Gly Asp Gly Gly Arg Leu Gly Gln His 4625 4630 4635 tca ggc aga gga gga cag cct gca aga cag tct gga gga aga cga 25702 Ser Gly Arg Gly Gly Gln Pro Ala Arg Gln Ser Gly Gly Arg Arg 4640 4645 4650 gga gga ggc aga ggt gga aga agc agc cgc cgc cag acc gtc gtc 25747 Gly Gly Gly Arg Gly Gly Arg Ser Ser Arg Arg Gln Thr Val Val 4655 4660 4665 ctc ggc ggg gga gaa agc aag cag cac gga tac cat ctc cgc tcc 25792 Leu Gly Gly Gly Glu Ser Lys Gln His Gly Tyr His Leu Arg Ser 4670 4675 4680 ggg tcg ggg tcc cgc tcg gcc cca cag tagatgggac gagaccgggc 25839 Gly Ser Gly Ser Arg Ser Ala Pro Gln 4685 4690 gattcccgaa ccccaccacc cagaccggta agaaggagcg gcagggatac aagtcctggc 25899 gggggcacaa aaacgccatc gtctcctgct tgcaggcctg cgggggcaac atctccttca 25959 cccggcgcta cctgctcttc caccgcgggg tgaacttccc ccgcaacatc ttgcattact 26019 accgtcacct ccacagcccc tactacttcc aagaagaggc agcagaaaaa gaccagaaaa 26079 ccagctagaa aatccacagc ggcggcagca ggtggactga ggatcgcggc gaacgagccg 26139 gcgcagaccc gggagctgag gaaccggatc tttcccaccc tctatgccat cttccagcag 26199 agtcgggggc aggagcagga actgaaagtc aagaaccgtt ctctgcgctc gctcacccgc 26259 agttgtctgt atcacaagag cgaagaccaa cttcagcgca ctctcgagga cgccgaggct 26319 ctcttcaaca agtactgcgc gctcactctt aaagagtagc ccgcgcccgc ccacacacgg 26379 aaaaaggcgg gaattacgtc accacctgcg cccttcgccc gaccatc atg agc aaa 26435 Met Ser Lys gag att ccc acg cct tac atg tgg agc tac cag ccc cag atg ggc 26480 Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln Met Gly 4695 4700 4705 ctg gcc gcc ggc gcc gcc cag gac tac tcc acc cgc atg aac tgg 26525 Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn Trp 4710 4715 4720 ctc agt gcc ggg ccc gcg atg atc tca cgg gtg aat gac atc cgc 26570 Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 4725 4730 4735 gcc cgc cga aac cag ata ctc cta gaa cag tca gcg atc gcc gcc 26615 Ala Arg Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Ala Ala 4740 4745 4750 acg ccc cgc cat cac ctt aat ccg cgt aat tgg ccc gcc gcc ctg 26660 Thr Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu 4755 4760 4765 gtg tac cag gaa att ccc cag ccc acg acc gta cta ctt ccg cga 26705 Val Tyr Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg 4770 4775 4780 gac gcc cag gcc gaa gtc cag ctg act aac tca ggt gtc cag ctg 26750 Asp Ala Gln Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu 4785 4790 4795 gcc ggc ggc gcc gcc ctg tgt cgt cac cgc ccc gct cag ggt ata 26795 Ala Gly Gly Ala Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile 4800 4805 4810 aag cgg ctg gtg atc cga ggc aga ggc aca cag ctc aac gac gag 26840 Lys Arg Leu Val Ile Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu 4815 4820 4825 gtg gtg agc tct tcg ctg ggt ctg cga cct gac gga gtc ttc caa 26885 Val Val Ser Ser Ser Leu Gly Leu Arg Pro Asp Gly Val Phe Gln 4830 4835 4840 ctc gcc gga tcg ggg aga tct tcc ttc acg cct cgt cag gcc gtc 26930 Leu Ala Gly Ser Gly Arg Ser Ser Phe Thr Pro Arg Gln Ala Val 4845 4850 4855 ctg act ttg gag agt tcg tcc tcg cag ccc cgc tcg ggc ggc atc 26975 Leu Thr Leu Glu Ser Ser Ser Ser Gln Pro Arg Ser Gly Gly Ile 4860 4865 4870 ggc act ctc cag ttc gtg gag gag ttc act ccc tcg gtc tac ttc 27020 Gly Thr Leu Gln Phe Val Glu Glu Phe Thr Pro Ser Val Tyr Phe 4875 4880 4885 aac ccc ttc tcc ggc tcc ccc ggc cac tac ccg gac gag ttc atc 27065 Asn Pro Phe Ser Gly Ser Pro Gly His Tyr Pro Asp Glu Phe Ile 4890 4895 4900 ccg aac ttc gac gcc atc agc gag tcg gtg gac ggc tac gat tga 27110 Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp Gly Tyr Asp 4905 4910 4915 atg tcc cat ggt ggc gca gct gac cta gct cgg ctt cga cac ctg 27155 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu 4920 4925 4930 gac cac tgc cgc cgc ttc cgc tgc ttc gct cgg gat ctc gcc gag 27200 Asp His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu 4935 4940 4945 ttt gcc tac ttt gag ctg ccc gag gag cac cct cag ggc cca gcc 27245 Phe Ala Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala 4950 4955 4960 cac gga gtg cgg atc atc gtc gaa ggg ggc ctc gac tcc cac ctg 27290 His Gly Val Arg Ile Ile Val Glu Gly Gly Leu Asp Ser His Leu 4965 4970 4975 ctt cgg atc ttc agc cag cga ccg atc ctg gtc gag cgc gaa caa 27335 Leu Arg Ile Phe Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln 4980 4985 4990 gga cag acc cgt ctg acc ctg tac tgc atc tgc aac cac ccc ggc 27380 Gly Gln Thr Arg Leu Thr Leu Tyr Cys Ile Cys Asn His Pro Gly 4995 5000 5005 ctg cat gaa agt ctt tgt tgt ctg ctg tgt act gag tat aat aaa 27425 Leu His Glu Ser Leu Cys Cys Leu Leu Cys Thr Glu Tyr Asn Lys 5010 5015 5020 agc tgagatcagc gactactccg gactcgattg tggtgttcct gctatcaacc 27478 Ser ggtccctgtt cttcaccggg aacgaaaccg agctccagct ccagtgtaag ccccacaaga 27538 agtacctcac ctggctgttc cagggctccc ccatcgccgt tgtcaaccac tgcgacaacg 27598 acggagtcct gctgagcggc cctgccaacc ttactttttc cacccgcaga agcaagctcc 27658 agctcttcca acccttcctc cccgggacct atcagtgcgt ctcgggaccc tgccatcaca 27718 ccttccacct gatcccgaat accacagcgc cgctccccgc tactaacaac caaactaacc 27778 tccaccaacg ccaccgtcgc gacctttcct ctgaatctaa taccactacc ggaggtgagc 27838 tccgaggtcg accaacctct gggatttact acggcccctg ggaggtggtg gggttaatag 27898 cgctaggcct agttgtgggt gggcttttgg ctctctgcta cctatacctc ccttgctgtt 27958 cgtacttagt ggtgctgtgt tgctggttta agaa atg ggg cag atc acc cta 28010 Met Gly Gln Ile Thr Leu 5025 5030 gtg agc tgc ggt gtg ctg gtg gcg gtg ctt tcg att gtg gga ctg 28055 Val Ser Cys Gly Val Leu Val Ala Val Leu Ser Ile Val Gly Leu 5035 5040 5045 ggc ggc gcg gct gta gtg aag gag gag aag gcc gat ccc tgc ttg 28100 Gly Gly Ala Ala Val Val Lys Glu Glu Lys Ala Asp Pro Cys Leu 5050 5055 5060 cat ttc aat ccc gac aaa tgc cag ctg agt ttt cag ccc gat ggc 28145 His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe Gln Pro Asp Gly 5065 5070 5075 aat cgg tgc gcg gtg ctg atc aag tgc gga tgg gaa tgc gag aac 28190 Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys Glu Asn 5080 5085 5090 gtg aga atc gag tac aat aac aag act cgg aac aat act ctc gcg 28235 Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu Ala 5095 5100 5105 tcc gtg tgg cag ccc ggg gac ccc gag tgg tac acc gtc tct gtc 28280 Ser Val Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 5110 5115 5120 ccc ggt gct gac ggc tcc ccg cgc acc gtg aat aat act ttc att 28325 Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile 5125 5130 5135 ttt gcg cac atg tgc aac acg gtc atg tgg atg agc aag cag tac 28370 Phe Ala His Met Cys Asn Thr Val Met Trp Met Ser Lys Gln Tyr 5140 5145 5150 gat atg tgg ccc ccc acg aag gag aac atc gtg gtc ttc tcc atc 28415 Asp Met Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile 5155 5160 5165 gct tac agc ctg tgc acg gcg cta atc acc gct atc gtg tgc ctg 28460 Ala Tyr Ser Leu Cys Thr Ala Leu Ile Thr Ala Ile Val Cys Leu 5170 5175 5180 agc att cac atg ctc atc gct att cgc ccc aga aat aat gcc gag 28505 Ser Ile His Met Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu 5185 5190 5195 aaa gag aaa cag cca taacacgttt tttcacacac cttgttttta cagaca atg 28559 Lys Glu Lys Gln Pro Met 5200 cgt ctg tta aat ttt tta aac att gtg ctc agt att gct tat gcc 28604 Arg Leu Leu Asn Phe Leu Asn Ile Val Leu Ser Ile Ala Tyr Ala 5205 5210 5215 tct ggt tat gca aac ata cag aaa acc ctt tat gta gga tct gat 28649 Ser Gly Tyr Ala Asn Ile Gln Lys Thr Leu Tyr Val Gly Ser Asp 5220 5225 5230 ggt aca cta gag ggt acc caa tca caa gcc aag gtt gca tgg tat 28694 Gly Thr Leu Glu Gly Thr Gln Ser Gln Ala Lys Val Ala Trp Tyr 5235 5240 5245 ttt tat aga acc aac act gat cca gtt aaa ctt tgt aag ggt gaa 28739 Phe Tyr Arg Thr Asn Thr Asp Pro Val Lys Leu Cys Lys Gly Glu 5250 5255 5260 ttg ccg cgt aca cat aaa act cca ctt aca ttt agt tgc agc aat 28784 Leu Pro Arg Thr His Lys Thr Pro Leu Thr Phe Ser Cys Ser Asn 5265 5270 5275 aat aat ctt aca ctt ttt tca att aca aaa caa tat act ggt act 28829 Asn Asn Leu Thr Leu Phe Ser Ile Thr Lys Gln Tyr Thr Gly Thr 5280 5285 5290 tat tac agt aca aac ttt cat aca gga caa gat aaa tat tat act 28874 Tyr Tyr Ser Thr Asn Phe His Thr Gly Gln Asp Lys Tyr Tyr Thr 5295 5300 5305 gtt aag gta gaa aat cct acc act cct aga act acc acc acc acc 28919 Val Lys Val Glu Asn Pro Thr Thr Pro Arg Thr Thr Thr Thr Thr 5310 5315 5320 acc act act gca aag ccc act gtg aaa act aca act agg acc acc 28964 Thr Thr Thr Ala Lys Pro Thr Val Lys Thr Thr Thr Arg Thr Thr 5325 5330 5335 aca act aca gaa acc acc acc agc aca aca ctt gct gca act aca 29009 Thr Thr Thr Glu Thr Thr Thr Ser Thr Thr Leu Ala Ala Thr Thr 5340 5345 5350 cac aca cac act aag cta acc tta cag acc act aat gat ttg atc 29054 His Thr His Thr Lys Leu Thr Leu Gln Thr Thr Asn Asp Leu Ile 5355 5360 5365 gcc ctg ctg caa aag ggg gat aac agc acc act tcc aat gag gag 29099 Ala Leu Leu Gln Lys Gly Asp Asn Ser Thr Thr Ser Asn Glu Glu 5370 5375 5380 ata ccc aaa tcc atg att ggc att att gtt gct gta gtg gtg tgc 29144 Ile Pro Lys Ser Met Ile Gly Ile Ile Val Ala Val Val Val Cys 5385 5390 5395 atg ttg atc atc gcc ttg tgc atg gtg tac tat gcc ttc tgc tac 29189 Met Leu Ile Ile Ala Leu Cys Met Val Tyr Tyr Ala Phe Cys Tyr 5400 5405 5410 aga aag cac aga ctg aac gac aag ctg gaa cac tta cta agt gtt 29234 Arg Lys His Arg Leu Asn Asp Lys Leu Glu His Leu Leu Ser Val 5415 5420 5425 gaa ttt taatttttta gaacc atg aag atc cta ggc ctt ttt agt ttt 29282 Glu Phe Met Lys Ile Leu Gly Leu Phe Ser Phe 5430 5435 tct atc att acc tct gct ctt tgt gaa tca gtg gat aga gat gtt 29327 Ser Ile Ile Thr Ser Ala Leu Cys Glu Ser Val Asp Arg Asp Val 5440 5445 5450 act att acc act ggt tct aat tat aca ctg aaa ggg cca ccc tca 29372 Thr Ile Thr Thr Gly Ser Asn Tyr Thr Leu Lys Gly Pro Pro Ser 5455 5460 5465 ggt atg ctt tcg tgg tat tgc tat ttt gga act gac act gat caa 29417 Gly Met Leu Ser Trp Tyr Cys Tyr Phe Gly Thr Asp Thr Asp Gln 5470 5475 5480 act gaa tta tgc aat ttt caa aaa ggc aaa acc tca aac tct aaa 29462 Thr Glu Leu Cys Asn Phe Gln Lys Gly Lys Thr Ser Asn Ser Lys 5485 5490 5495 atc tct aat tat caa tgc aat ggc act gat ctg ata cta ctc aat 29507 Ile Ser Asn Tyr Gln Cys Asn Gly Thr Asp Leu Ile Leu Leu Asn 5500 5505 5510 gtc acg aaa gca tat ggt ggc agt tat tat tgc cct gga caa aac 29552 Val Thr Lys Ala Tyr Gly Gly Ser Tyr Tyr Cys Pro Gly Gln Asn 5515 5520 5525 act gaa gaa atg att ttt tac aaa gtg gaa gtg gtt gat ccc act 29597 Thr Glu Glu Met Ile Phe Tyr Lys Val Glu Val Val Asp Pro Thr 5530 5535 5540 aca cca ccc acc acc aca act att cat acc aca cac aca gaa caa 29642 Thr Pro Pro Thr Thr Thr Thr Ile His Thr Thr His Thr Glu Gln 5545 5550 5555 aca cca gag gca aca gaa gca gag ttg gcc ttc cag gtt cac gga 29687 Thr Pro Glu Ala Thr Glu Ala Glu Leu Ala Phe Gln Val His Gly 5560 5565 5570 gat tcc ttt gct gtc aat acc cct aca ccc gat cag cgg tgt ccg 29732 Asp Ser Phe Ala Val Asn Thr Pro Thr Pro Asp Gln Arg Cys Pro 5575 5580 5585 ggg ccg cta gtc agc ggc att gtc ggt gtg ctt tcg gga tta gca 29777 Gly Pro Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly Leu Ala 5590 5595 5600 gtc ata atc atc tgc atg ttc att ttt gct tgc tgc tat aga agg 29822 Val Ile Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg 5605 5610 5615 ctt tac cga caa aaa tca gac cca ctg ctg aac ctc tat gtt 29864 Leu Tyr Arg Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 5620 5625 5630 taattttttc cagagcc atg aag gca gtt agc gct cta gtt ttt tgt tct 29914 Met Lys Ala Val Ser Ala Leu Val Phe Cys Ser 5635 5640 ttg att gac att gtt ttt aat agt aaa att acc aaa gtt agc ttt 29959 Leu Ile Asp Ile Val Phe Asn Ser Lys Ile Thr Lys Val Ser Phe 5645 5650 5655 att aaa cat gtt aat gta act gaa gga gat aac atc aca cta gca 30004 Ile Lys His Val Asn Val Thr Glu Gly Asp Asn Ile Thr Leu Ala 5660 5665 5670 ggt gta gaa ggt gct caa aac acc acc tgg aca aaa tac cat cta 30049 Gly Val Glu Gly Ala Gln Asn Thr Thr Trp Thr Lys Tyr His Leu 5675 5680 5685 gga tgg aga gat att tgc acc tgg aat gta act tat tat tgc ata 30094 Gly Trp Arg Asp Ile Cys Thr Trp Asn Val Thr Tyr Tyr Cys Ile 5690 5695 5700 gga att aat ctt acc att gtt aac gct aac caa tct cag aat ggg 30139 Gly Ile Asn Leu Thr Ile Val Asn Ala Asn Gln Ser Gln Asn Gly 5705 5710 5715 tta att aaa gga cag agt gtt agt gtg acc agt gat ggg tac tat 30184 Leu Ile Lys Gly Gln Ser Val Ser Val Thr Ser Asp Gly Tyr Tyr 5720 5725 5730 acc cag cat agt ttt aac tac aac att act gtc ata cca ctg cct 30229 Thr Gln His Ser Phe Asn Tyr Asn Ile Thr Val Ile Pro Leu Pro 5735 5740 5745 acg cct agc cca cct agc act acc aca cag aca acc aca tac agt 30274 Thr Pro Ser Pro Pro Ser Thr Thr Thr Gln Thr Thr Thr Tyr Ser 5750 5755 5760 aca tca aat cag cct acc acc act aca gca gca gag gtt gcc agc 30319 Thr Ser Asn Gln Pro Thr Thr Thr Thr Ala Ala Glu Val Ala Ser 5765 5770 5775 tcg tct ggg gtc cga gtg gca ttt ttg atg ttg gcc cca tct agc 30364 Ser Ser Gly Val Arg Val Ala Phe Leu Met Leu Ala Pro Ser Ser 5780 5785 5790 agt ccc act gct agt acc aat gag cag act act gaa ttt ttg tcc 30409 Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Glu Phe Leu Ser 5795 5800 5805 act gtc gag agc cac acc aca gct acc tcc agt gcc ttc tct agc 30454 Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe Ser Ser 5810 5815 5820 acc gcc aat ctc tcc tcg ctt tcc tct aca cca atc agc ccc gct 30499 Thr Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro Ala 5825 5830 5835 act act cct agc ccc gct cct ctt ccc act ccc ctg aag caa aca 30544 Thr Thr Pro Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys Gln Thr 5840 5845 5850 gac ggc ggc atg caa tgg cag atc acc ctg ctc att gtg atc ggg 30589 Asp Gly Gly Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly 5855 5860 5865 ttg gtc atc ctg gcc gtg ttg ctc tac tac atc ttc tgc cgc cgc 30634 Leu Val Ile Leu Ala Val Leu Leu Tyr Tyr Ile Phe Cys Arg Arg 5870 5875 5880 att ccc aac gcg cac cgc aag ccg gcc tac aag ccc atc gtt atc 30679 Ile Pro Asn Ala His Arg Lys Pro Ala Tyr Lys Pro Ile Val Ile 5885 5890 5895 ggg cag ccg gag ccg ctt cag gtg gaa ggg ggt cta agg aat ctt 30724 Gly Gln Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu 5900 5905 5910 ctc ttc tct ttt aca gta tgg tgattgaact atgattccta gacaattctt 30775 Leu Phe Ser Phe Thr Val Trp 5915 gatcactatt cttatctgcc tcctccaagt ctgtgccacc ctcgctctgg tggccaacgc 30835 cagtccagac tgtattgggc ccttcgcctc ctacgtgctc tttgccttca tcacctgcat 30895 ctgctgctgt agcatagtct gcctgcttat caccttcttc cagttcattg actggatctt 30955 tgtgcgcatc gcctacctgc gccaccaccc ccagtaccgc gaccagcgag tggcgcagct 31015 gctcaggctc ctctgataag c atg cgg gct ctg cta ctt ctc gca ctt ctg 31066 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu 5920 5925 ctg tta gtg ctc ccc cgt ccc gtt gac ccc cgg ccc ccc act cag 31111 Leu Leu Val Leu Pro Arg Pro Val Asp Pro Arg Pro Pro Thr Gln 5930 5935 5940 tcc ccc gag gag gtc cgc aaa tgc aaa ttc caa gaa ccc tgg aaa 31156 Ser Pro Glu Glu Val Arg Lys Cys Lys Phe Gln Glu Pro Trp Lys 5945 5950 5955 ttc ctc aaa tgc tac cgc caa aaa tca gac atg cat ccc agc tgg 31201 Phe Leu Lys Cys Tyr Arg Gln Lys Ser Asp Met His Pro Ser Trp 5960 5965 5970 atc atg atc att ggg atc gtg aac att ctg gcc tgc acc ctc atc 31246 Ile Met Ile Ile Gly Ile Val Asn Ile Leu Ala Cys Thr Leu Ile 5975 5980 5985 tcc ttt gtg att tac ccc tgc ttt gac ttt ggt tgg aac tcg cca 31291 Ser Phe Val Ile Tyr Pro Cys Phe Asp Phe Gly Trp Asn Ser Pro 5990 5995 6000 gag gcg ctc tat ctc ccg cct gaa cct gac aca cca cca cag caa 31336 Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr Pro Pro Gln Gln 6005 6010 6015 cct cag gca cac gca cta cca cca cca cca cag cct agg cca caa 31381 Pro Gln Ala His Ala Leu Pro Pro Pro Pro Gln Pro Arg Pro Gln 6020 6025 6030 tac atg ccc ata tta gac tat gag gcc gag cca cag cga ccc atg 31426 Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg Pro Met 6035 6040 6045 ctc ccc gct att agt tac ttc aat cta acc ggc gga gat gac 31468 Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 6050 6055 6060 tgacccactg gccaacaaca acgtcaacga ccttctcctg gacatggacg gccgcgcctc 31528 ggagcagcga ctcgcccaac ttcgcattcg ccagcagcag gagagagccg tcaaggagct 31588 gcaggacggc atagccatcc accagtgcaa gaaaggcatc ttctgcctgg tgaaacaggc 31648 caagatctcc tacgaggtca cccagaccga ccatcgcctc tcctacgagc tcctgcagca 31708 gcgccagaag ttcacctgcc tggtcggagt caaccccatc gtcatcaccc agcagtcggg 31768 cgataccaag gggtgcatcc actgctcctg cgactccccc gactgcgtcc acactctgat 31828 caagaccctc tgcggcctcc gcgacctcct ccccatgaac taatcacccc cttatccagt 31888 gaaataaaga tcatattgat gattaaataa aaaaaataat catttgattt gaaataaaga 31948 tacaatcata ttgatgattt gagtttaata aaaataaaga atcacttact tgaaatctga 32008 taccaggtct ctgtccatgt tttctgccaa caccacttca ctcccctctt cccagctctg 32068 gtactgcagg ccccggcggg ctgcaaactt cctccacacc ctgaagggga tgtcaaattc 32128 ctcctgtccc tcaatcttca ttttatcttc tatcag atg tcc aaa aag cgc gtc 32182 Met Ser Lys Lys Arg Val 6065 cgg gtg gat gat gac ttc gac ccc gtc tac ccc tac gat gca gac 32227 Arg Val Asp Asp Asp Phe Asp Pro Val Tyr Pro Tyr Asp Ala Asp 6070 6075 6080 aac gca ccg acc gtg ccc ttc atc aac ccc ccc ttc gtc tct tca 32272 Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro Phe Val Ser Ser 6085 6090 6095 gat gga ttc caa gag aag ccc ctg ggg gtg ctg tcc ctg cgt ctg 32317 Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser Leu Arg Leu 6100 6105 6110 gcc gat ccc gtc acc acc aag aac ggg gaa atc acc ctc aag ctg 32362 Ala Asp Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu Lys Leu 6115 6120 6125 gga gat ggg gtg gac ctc gac gac tcg gga aaa ctc atc tcc aac 32407 Gly Asp Gly Val Asp Leu Asp Asp Ser Gly Lys Leu Ile Ser Asn 6130 6135 6140 acg gcc acc aag gcc gcc gcc cct ctc agt ttt tcc aac aac acc 32452 Thr Ala Thr Lys Ala Ala Ala Pro Leu Ser Phe Ser Asn Asn Thr 6145 6150 6155 att tcc ctt aac atg gat acc cct ctt tac aac aac aat gga aag 32497 Ile Ser Leu Asn Met Asp Thr Pro Leu Tyr Asn Asn Asn Gly Lys 6160 6165 6170 cta ggt atg aag gta acc gca cca tta aag ata tta gac aca gat 32542 Leu Gly Met Lys Val Thr Ala Pro Leu Lys Ile Leu Asp Thr Asp 6175 6180 6185 cta cta aaa aca ctt gtt gtt gct tat ggg cag gga tta gga aca 32587 Leu Leu Lys Thr Leu Val Val Ala Tyr Gly Gln Gly Leu Gly Thr 6190 6195 6200 aac acc aat ggt gct ctt gtt gcc caa cta gca tac cca ctt gtt 32632 Asn Thr Asn Gly Ala Leu Val Ala Gln Leu Ala Tyr Pro Leu Val 6205 6210 6215 ttt aat acc gct agc aaa att gcc ctt aat tta ggc aat gga cca 32677 Phe Asn Thr Ala Ser Lys Ile Ala Leu Asn Leu Gly Asn Gly Pro 6220 6225 6230 tta aaa gtg gat gca aat aga ctg aac att aat tgc aaa aga ggt 32722 Leu Lys Val Asp Ala Asn Arg Leu Asn Ile Asn Cys Lys Arg Gly 6235 6240 6245 atc tat gtc act acc aca aaa gat gca ctg gag att aat atc agt 32767 Ile Tyr Val Thr Thr Thr Lys Asp Ala Leu Glu Ile Asn Ile Ser 6250 6255 6260 tgg gca aat gct atg aca ttt ata gga aat gcc att ggt gtc aat 32812 Trp Ala Asn Ala Met Thr Phe Ile Gly Asn Ala Ile Gly Val Asn 6265 6270 6275 att gac aca aaa aaa ggc cta cag ttc ggc act tca agc act gaa 32857 Ile Asp Thr Lys Lys Gly Leu Gln Phe Gly Thr Ser Ser Thr Glu 6280 6285 6290 aca gat gtt aaa aat gct ttt cca ctc caa gta aaa ctt gga gct 32902 Thr Asp Val Lys Asn Ala Phe Pro Leu Gln Val Lys Leu Gly Ala 6295 6300 6305 ggt ctt aca ttt gac agc aca ggt gcc att gtt gct tgg aac aaa 32947 Gly Leu Thr Phe Asp Ser Thr Gly Ala Ile Val Ala Trp Asn Lys 6310 6315 6320 gaa gat gac aaa ctt aca ctg tgg acc aca gcc gat cca tct cca 32992 Glu Asp Asp Lys Leu Thr Leu Trp Thr Thr Ala Asp Pro Ser Pro 6325 6330 6335 aac tgt cac ata tat tct gca aag gat gct aag ctt aca ctc tgc 33037 Asn Cys His Ile Tyr Ser Ala Lys Asp Ala Lys Leu Thr Leu Cys 6340 6345 6350 ttg aca aag tgt ggt agt cag ata ctg ggc act gtt tct ctc ata 33082 Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Ser Leu Ile 6355 6360 6365 gct gtt gat act ggt agc tta aat cca ata aca gga caa gta acc 33127 Ala Val Asp Thr Gly Ser Leu Asn Pro Ile Thr Gly Gln Val Thr 6370 6375 6380 act gct ctt gtt tca ctt aaa ttc gat gcc aat gga gtt ttg caa 33172 Thr Ala Leu Val Ser Leu Lys Phe Asp Ala Asn Gly Val Leu Gln 6385 6390 6395 acc agt tca aca ttg gac aaa gaa tat tgg aat ttt aga aaa gga 33217 Thr Ser Ser Thr Leu Asp Lys Glu Tyr Trp Asn Phe Arg Lys Gly 6400 6405 6410 gat gtg aca cct gct gag cca tat act aat gct ata ggt ttt atg 33262 Asp Val Thr Pro Ala Glu Pro Tyr Thr Asn Ala Ile Gly Phe Met 6415 6420 6425 ccc aat ata aag gca tat ccg aaa aac aca aat tca gct gca aaa 33307 Pro Asn Ile Lys Ala Tyr Pro Lys Asn Thr Asn Ser Ala Ala Lys 6430 6435 6440 agt cac att gtg gga aaa gta tac cta cat ggg gaa gta agc aag 33352 Ser His Ile Val Gly Lys Val Tyr Leu His Gly Glu Val Ser Lys 6445 6450 6455 cca cta gac ttg ata att aca ttt aat gaa acc agt aat gaa acc 33397 Pro Leu Asp Leu Ile Ile Thr Phe Asn Glu Thr Ser Asn Glu Thr 6460 6465 6470 tgt acc tat tgc att aac ttt cag tgg cag tgg gga act gac aaa 33442 Cys Thr Tyr Cys Ile Asn Phe Gln Trp Gln Trp Gly Thr Asp Lys 6475 6480 6485 tat aaa aat gaa acg ctt gct gtc agt tca ttc acc ttt tcc tac 33487 Tyr Lys Asn Glu Thr Leu Ala Val Ser Ser Phe Thr Phe Ser Tyr 6490 6495 6500 att gcc caa gaa taaacccgcc ctgcatgtca accccattgt tcccaccact 33539 Ile Ala Gln Glu 6505 atggaaaact ctgaagcaga aaaataaagt tcaagtgttt tattgattca acagttttca 33599 cagaattcga gtagttattt ttcctccacc ctcccaggac atggaataca ccaccctctc 33659 cccccgcaca gccttgaaca tctgaatgtc attggtgatg gacatgcttt tggtctccac 33719 attccacaca gtttcagagc gagccagtct cgggtcggtc agggagatga aaccctccgg 33779 gcactcccgc atctgcacct caaagttcag tagctgaggg ctgtcctcgg tggtcgggat 33839 cacggttatc tggaagaagc agaagagcgg cggtgggaat catagtccgc gaacgggatc 33899 ggccggtggt gtcgcatcag gccccgcagc agtcgctgtc gccgccgctc cgtcaaactg 33959 ctgctcaggg ggtccgggtc cagggactcc ctcagcatga tgcccacggc cctcagcatc 34019 agtcgcctgg tgcggcgggc gcagcagcgc atgcggatct cgctcaggtc gctgcagtac 34079 gtgcaacaca ggaccaccag gttgttcaac agtccatagt tcaacacgct ccagccgaaa 34139 ctcatcgcgg gaaggatgct acccacgtgg ccgtcgtacc agatcctcag gtaaatcaag 34199 tggcgctccc tccagaacac gctgcccaca tacatgatct ccttgggcat gtggtggttc 34259 accacctccc ggtaccacat caccctctgg ttgaacatgc agccccggat gatcctgcgg 34319 aaccacaggg ccagcaccgc cccgcccgcc atgcagcgaa gagaccccgg gtcccggcaa 34379 tggcaatgga ggacccaccg ctcgtacccg tggatcatct gggagctgaa caagtctatg 34439 ttggcacagc acaggcacac gctcatgcat ctcttcagca ctctcagctc ctcgggggtc 34499 aaaaccatat cccagggcac ggggaactct tgcaggacag cgaaccccgc agaacagggc 34559 aatcctcgca cataacttac attgtgcatg gacagggtat cgcaatcagg cagcaccggg 34619 tgatcctcca ccagagaagc gcgggtctcg gtttcctcac agcgtggtaa gggggccggc 34679 cgatacgggt gatggcggga cgcggctgat cgtgttctcg accgtgtcat gatgcagttg 34739 ctttcggaca ttttcgtact tgctgtagca gaacctggtc cgggcgctgc acaccgatcg 34799 ccggcggcgg tctcggcgct tggaacgctc ggtgttgaaa ttgtaaaaca gccactctct 34859 cagaccgtgc agcagatcta gggcctcagg agtgatgaag atcccatcat gcctgatggc 34919 tctgatcaca tcgaccaccg tggaatgggc cagacccagc cagatgatgc aattttgttg 34979 ggtttcggtg acggcggggg agggaagaac aggaagaacc atgattaact tttaatccaa 35039 acggtctcgg agcacttcaa aatgaaggtc gcggagatgg cacctctcgc ccccgctgtg 35099 ttggtggaaa ataacagcca ggtcaaaggt gatacggttc tcgagatgtt ccacggtggc 35159 ttccagcaaa gcctccacgc gcacatccag aaacaagaca atagcgaaag cgggagggtt 35219 ctctaattcc tcaatcatca tgttacactc ctgcaccatc cccagataat tttcattttt 35279 ccagccttga atgattcgaa ctagttcctg aggtaaatcc aagccagcca tgataaagag 35339 ctcgcgcaga gcgccctcca ccggcattct taagcacacc ctcataattc caagagattc 35399 tgctcctggt tcacctgcag cagattaaca aggggaatat caaaatctct gccgcgatct 35459 ctaagctcct ccctcagcaa taactgcaag tactctttca tatcttctcc gaaattttta 35519 gccatagggc cgccaggaat gagagcaggg caagccacat tacagataaa gcgaagtcct 35579 ccccagtgag cattgccaaa tgtaagattg aaataagcat gctggctaga cccggtgata 35639 tcttccagat aactggacag aaaatcaggc aagcaatttt taagaaaatc aacaaaagaa 35699 aagtcgtcca ggtgcaagtt tagagcctca ggaacaacga tggaataagt gcaaggagtg 35759 cgttccagca tggttagtgt ttttttggtg atctgtagaa caaaaaataa acatgcaata 35819 ttaaaccatg ctagcctggc gaacaggtgg gtaaatcact ctttccagca ccaggcaggc 35879 tacggggtct ccggcgcgac cctcgtagaa gctgtcgcca tgattgaaaa gcatcaccga 35939 aagactttcc cggtggccgg catggatgat tcgcgaagac gcgtacactc cgggaacatt 35999 ggcatccgtg agtgaaaaaa atcgccccaa gaagccccga ggcactacaa tgctcaacct 36059 taattccagc agagcgaccc catgcggatg aagcacaaaa ttggtaggtg cgtaaaaaat 36119 gtaattactc ccctcctgca caggcagcaa agcccccgct ccctccagaa acacatacaa 36179 agcctcagcg tccatagctt accgagcacg gcaggcgcaa gattcagaga aaaggctgag 36239 ctctaacctg actgcccgct cctgagctca atatatagcc ctaacctaca ctgacgtaaa 36299 ggccaaagtc taaaaatacc cgccaaaatg acacacacgc ccagcacacg cccagaaacc 36359 ggtgacacac tcaaaaaaat acgtgcgctt cctcaaacgc ccaaaccggc gtcatttccg 36419 ggttcccacg ctacgtcacc gctcagcgac tttcaaattt cgtcgaccgt taaacacgtc 36479 actcgccccg cccctaacgg tcgccgctcc cacagccaat caccttcctc catccccaaa 36539 ttcaaacggc tcatttgcat attaacgcgc accaaaagtt tgaggtatat tatwkakrww 36599 gatcatttaa atatgcggtg tgaaataccg cacagatgcg taaggagaaa ataccgcatc 36659 aggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga 36719 gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca 36779 ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg 36839 ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt 36899 cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc 36959 ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct 37019 tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc 37079 gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta 37139 tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca 37199 gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag 37259 tggtggccta actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag 37319 ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt 37379 agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa 37439 gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg 37499 attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga 37559 agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta 37619 atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc 37679 cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg 37739 ataccgcgag acccacgctc accggctcca gatttatcag caataaacca gccagccgga 37799 agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt 37859 tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt 37919 gctgcaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc 37979 caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc 38039 ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca 38099 gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag 38159 tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg 38219 tcaacacggg ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa 38279 cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa 38339 cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga 38399 gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga 38459 atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg 38519 agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt 38579 ccccgaaaag tgccacctga cgtctaagaa accattatta tcatgacatt aacctataaa 38639 aataggcgta tcacgaggcc ctttcgtctt caag 38673 <210> 152 <211> 363 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 152 Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 1 5 10 15 Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 20 25 30 His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 35 40 45 Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 50 55 60 Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 65 70 75 80 Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 85 90 95 Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 100 105 110 Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val 115 120 125 Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 130 135 140 Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 145 150 155 160 Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 165 170 175 Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 180 185 190 Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 195 200 205 Ala Ala Asp Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 210 215 220 Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 225 230 235 240 Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 245 250 255 Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 260 265 270 Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 275 280 285 Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 290 295 300 Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 305 310 315 320 Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 325 330 335 Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 340 345 350 Val Gly Gly Pro Gly His Lys Ala Arg Val Leu 355 360 <210> 153 <211> 392 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 153 Met His Pro Val Leu Arg Gln Met Arg Pro His Pro Pro Pro Gln Pro 1 5 10 15 Pro Leu Pro Gln Gln Gln Gln Gln Pro Ala Leu Leu Pro Pro Pro Gln 20 25 30 Gln Gln Gln Gln Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala 35 40 45 Gly Val Gln Tyr Asp Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala Arg 50 55 60 Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys Arg 65 70 75 80 Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp Arg 85 90 95 Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ser Arg Phe His Ala Gly 100 105 110 Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp Glu 115 120 125 Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala His 130 135 140 Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys Glu 145 150 155 160 Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu Ile 165 170 175 Ala Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu Leu 180 185 190 Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln Leu 195 200 205 Phe Leu Val Val Gln His Ser Arg Asp Asn Glu Thr Phe Arg Glu Ala 210 215 220 Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu Val 225 230 235 240 Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu Ser 245 250 255 Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys Tyr 260 265 270 Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys Glu 275 280 285 Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu Thr 290 295 300 Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg Ala 305 310 315 320 Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met His 325 330 335 Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser Tyr 340 345 350 Phe Asp Met Gly Ala Asp Leu Arg Trp Gln Pro Ser Arg Arg Ala Leu 355 360 365 Glu Ala Ala Gly Gly Val Pro Tyr Val Glu Glu Val Asp Asp Glu Glu 370 375 380 Glu Glu Gly Glu Tyr Leu Glu Asp 385 390 <210> 154 <211> 586 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 154 Met Gln Gln Gln Pro Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu 1 5 10 15 Gln Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala 20 25 30 Met Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg 35 40 45 Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val 50 55 60 Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn 65 70 75 80 Ala Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val 85 90 95 Tyr Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val 100 105 110 Gln Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ser 115 120 125 Gln Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala 130 135 140 Leu Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln 145 150 155 160 Glu Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Ala Glu 165 170 175 Val Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln 180 185 190 Thr Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys 195 200 205 Asn Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala 210 215 220 Thr Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu 225 230 235 240 Val Ala Pro Phe Thr Asp Ser Gly Ser Val Ser Arg Asp Ser Tyr Leu 245 250 255 Gly Tyr Leu Leu Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val 260 265 270 Asp Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly 275 280 285 Gln Glu Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr 290 295 300 Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu 305 310 315 320 Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met 325 330 335 Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn 340 345 350 Met Glu Pro Ser Met Tyr Ala Arg Asn Arg Pro Phe Ile Asn Lys Leu 355 360 365 Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr 370 375 380 Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr 385 390 395 400 Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp 405 410 415 Val Asp Ser Ser Val Phe Ser Pro Arg Pro Thr Thr Thr Val Trp Lys 420 425 430 Lys Glu Gly Gly Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly Arg Ala 435 440 445 Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu 450 455 460 Pro Phe Ser Leu Asn Ser Val Arg Ser Ser Asp Leu Gly Arg Leu Thr 465 470 475 480 Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu 485 490 495 Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu 500 505 510 Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala His Glu His Arg Asp 515 520 525 Glu Pro Arg Ala Ser Ser Ser Thr Gly Ala Arg Arg Arg Gln Arg His 530 535 540 Asp Arg Gln Arg Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp Asp 545 550 555 560 Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe Ala 565 570 575 His Leu Arg Pro Arg Ile Gly Arg Leu Met 580 585 <210> 155 <211> 539 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 155 Met Met Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Val Ala Ala Ala Met Gln Pro Pro Leu Glu Ala 20 25 30 Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg Asn Ser 35 40 45 Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg Leu Tyr 50 55 60 Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr Gln Asn 65 70 75 80 Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp Phe Thr 85 90 95 Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg 100 105 110 Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro Asn Val 115 120 125 Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser 130 135 140 Arg Lys Thr Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln Asp Glu 145 150 155 160 Leu Thr Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn Phe Ser 165 170 175 Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr 180 185 190 Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val 195 200 205 Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val Thr Glu 210 215 220 Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro Asp Ile 225 230 235 240 Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg Leu Ser 245 250 255 Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly Phe Gln 260 265 270 Ile Leu Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp 275 280 285 Val Glu Ala Tyr Glu Lys Ser Lys Glu Glu Ala Ala Ala Ala Ala Thr 290 295 300 Ala Ala Val Ala Thr Ala Ala Thr Thr Asp Ala Asp Ala Ala Thr Thr 305 310 315 320 Thr Arg Gly Asp Thr Phe Ala Thr Gln Ala Glu Glu Ala Ala Ala Leu 325 330 335 Ala Ala Thr Asp Asp Ser Glu Ser Lys Ile Val Ile Lys Pro Val Glu 340 345 350 Lys Asp Ser Lys Asp Arg Ser Tyr Asn Val Leu Ser Asp Gly Lys Asn 355 360 365 Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly Asp Pro Glu 370 375 380 Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp Val Thr Cys 385 390 395 400 Gly Val Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met Gln Asp Pro 405 410 415 Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn Tyr Pro Val Val Gly 420 425 430 Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser Phe Phe Asn Glu Gln Ala 435 440 445 Val Tyr Ser Gln Gln Leu Arg Ala Phe Thr Ser Leu Thr His Val Phe 450 455 460 Asn Arg Phe Pro Glu Asn Gln Ile Leu Val Arg Pro Pro Ala Pro Thr 465 470 475 480 Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr 485 490 495 Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val Thr Val Thr 500 505 510 Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Val 515 520 525 Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 530 535 <210> 156 <211> 194 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 156 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Ala Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ser 130 135 140 Ser Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala 145 150 155 160 Ala Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val 165 170 175 Arg Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro 180 185 190 Arg Thr <210> 157 <211> 346 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 157 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys Glu Glu Arg Lys Pro Arg 20 25 30 Lys Leu Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Glu Asp Asp Gly 35 40 45 Leu Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp 50 55 60 Arg Gly Arg Lys Val Lys Pro Val Leu Arg Pro Gly Thr Thr Val Val 65 70 75 80 Phe Thr Pro Gly Glu Arg Ser Gly Ser Ala Ser Lys Arg Ser Tyr Asp 85 90 95 Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu 100 105 110 Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Pro Ala Pro Leu Lys Glu 115 120 125 Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu 130 135 140 Lys Pro Val Thr Leu Gln Gln Val Leu Pro Ser Ala Ala Pro Arg Arg 145 150 155 160 Gly Phe Lys Arg Glu Gly Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu 165 170 175 Met Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu His Met Lys 180 185 190 Val Asp Pro Glu Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln 195 200 205 Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr 210 215 220 Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr 225 230 235 240 Met Glu Val Gln Thr Asp Pro Trp Met Pro Ala Pro Ala Ser Thr Thr 245 250 255 Thr Arg Arg Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn 260 265 270 Tyr Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr 275 280 285 Arg Phe Tyr Arg Gly Tyr Ser Ser Arg Arg Lys Thr Thr Thr Arg Arg 290 295 300 Arg Arg Arg Arg Thr Arg Arg Ser Thr Thr Ala Thr Ser Ala Ala Ala 305 310 315 320 Leu Val Arg Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu Thr Leu Pro 325 330 335 Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 340 345 <210> 158 <211> 77 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 158 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly Asn Gly Leu Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 159 <211> 239 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 159 Met Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg 1 5 10 15 Pro Phe Met Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly 20 25 30 Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly 35 40 45 Ser Thr Leu Lys Thr Tyr Gly Asn Lys Ala Trp Asn Ser Ser Thr Gly 50 55 60 Gln Ala Leu Arg Glu Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val 65 70 75 80 Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn 85 90 95 Gln Ala Val Gln Lys Gln Ile Asn Ser Arg Leu Asp Ala Val Pro Pro 100 105 110 Ala Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu 115 120 125 Asp Lys Arg Gly Asp Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu 130 135 140 Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu 145 150 155 160 Gly Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu 165 170 175 Lys Pro Glu Ser Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Pro Thr 180 185 190 Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Arg Ala 195 200 205 Arg Pro Gly Ser Arg Pro Gln Ala Asn Trp Gln Ser Thr Leu Asn Ser 210 215 220 Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg Arg Arg Cys Tyr 225 230 235 <210> 160 <211> 944 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 160 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Ser Ser Gln Trp Glu Gln Thr Glu Asn Gly Gly Gly Gln 130 135 140 Ala Thr Thr Lys Thr His Thr Tyr Gly Val Ala Pro Met Gly Gly Thr 145 150 155 160 Asn Ile Thr Val Asp Gly Leu Gln Ile Gly Thr Asp Ala Thr Ala Asp 165 170 175 Thr Glu Lys Pro Ile Tyr Ala Asp Lys Thr Phe Gln Pro Glu Pro Gln 180 185 190 Ile Gly Glu Glu Asn Trp Gln Glu Thr Glu Ser Phe Tyr Gly Gly Arg 195 200 205 Ala Leu Lys Lys Asp Thr Asn Met Lys Pro Cys Tyr Gly Ser Phe Ala 210 215 220 Arg Pro Thr Asn Glu Lys Gly Gly Gln Ala Lys Leu Lys Val Gly Ala 225 230 235 240 Asp Gly Leu Pro Thr Lys Glu Phe Asp Ile Asp Leu Ala Phe Phe Asp 245 250 255 Thr Pro Gly Gly Thr Val Thr Gly Gly Thr Glu Glu Tyr Lys Ala Asp 260 265 270 Ile Val Met Tyr Thr Glu Asn Thr Tyr Leu Glu Thr Pro Asp Thr His 275 280 285 Val Val Tyr Lys Pro Gly Lys Asp Asn Thr Ser Ser Lys Ile Asn Leu 290 295 300 Val Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp 305 310 315 320 Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val 325 330 335 Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp 340 345 350 Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp 355 360 365 Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp 370 375 380 Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro 385 390 395 400 Asn Tyr Cys Phe Pro Leu Asp Gly Ser Gly Thr Asn Ala Ala Tyr Gln 405 410 415 Gly Val Lys Val Lys Asn Gly Gln Asp Gly Asp Val Glu Ser Glu Trp 420 425 430 Glu Lys Asp Asp Thr Val Ala Ala Arg Asn Gln Leu Cys Lys Gly Asn 435 440 445 Ile Phe Ala Met Glu Ile Asn Leu Gln Ala Asn Leu Trp Arg Ser Phe 450 455 460 Leu Tyr Ser Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr 465 470 475 480 Pro Ala Asn Ile Thr Leu Pro Thr Asn Thr Asn Thr Tyr Asp Tyr Met 485 490 495 Asn Gly Arg Val Val Pro Pro Ser Leu Val Asp Ala Tyr Ile Asn Ile 500 505 510 Gly Ala Arg Trp Ser Leu Asp Pro Met Asp Asn Val Asn Pro Phe Asn 515 520 525 His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn 530 535 540 Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala 545 550 555 560 Ile Lys Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn 565 570 575 Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp 580 585 590 Leu Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr 595 600 605 Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala 610 615 620 Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser 625 630 635 640 Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Val Pro 645 650 655 Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe 660 665 670 Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp 675 680 685 Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe 690 695 700 Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe Asp Ser Ser 705 710 715 720 Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu 725 730 735 Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn 740 745 750 Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile 755 760 765 Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr 770 775 780 Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu 785 790 795 800 Val Asn Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn 805 810 815 Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln 820 825 830 Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val 835 840 845 Thr Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met Trp Arg 850 855 860 Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu 865 870 875 880 Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Asn 885 890 895 Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr Val Val Phe 900 905 910 Glu Val Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile 915 920 925 Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 930 935 940 <210> 161 <211> 208 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 161 Met Ala Glu Pro Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile 1 5 10 15 Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg 20 25 30 Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn 35 40 45 Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp 50 55 60 Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser 65 70 75 80 Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu Leu 85 90 95 Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu Lys 100 105 110 Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu Phe 115 120 125 Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro Met 130 135 140 Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly Met 145 150 155 160 Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu Ala 165 170 175 Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe Arg Ser His Arg 180 185 190 Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Gln Asp Met 195 200 205 <210> 162 <211> 803 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 162 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ser 1 5 10 15 Thr Ala Asp Glu Asn Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro 20 25 30 Pro Ser Pro Thr Ser Asp Ala Ala Ala Pro Asp Met Gln Glu Met Glu 35 40 45 Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu 50 55 60 Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln Glu 65 70 75 80 Gln Pro Glu Gln Glu Ala Glu Asn Glu Gln Asn Gln Ala Gly His Glu 85 90 95 His Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu Ile Lys His Leu 100 105 110 Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Ala Glu 115 120 125 Val Pro Leu Ser Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg Asn Leu 130 135 140 Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys Glu 145 150 155 160 Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu Ala 165 170 175 Leu Ala Thr Tyr His Leu Phe Phe Lys Asn Gln Arg Ile Pro Val Ser 180 185 190 Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Phe Asn Leu Gly Pro 195 200 205 Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro Lys Ile 210 215 220 Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu Gln 225 230 235 240 Gly Glu Gly Gly Glu His Glu His His Ser Ala Leu Val Glu Leu Glu 245 250 255 Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu Thr 260 265 270 His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser Ala 275 280 285 Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Ile Ser Glu Asp 290 295 300 Glu Gly Met Gln Asp Pro Glu Ser Thr Glu Asp Gly Lys Pro Val Val 305 310 315 320 Ser Asp Glu Gln Leu Ala Arg Trp Leu Gly Pro Asn Ala Ser Pro Gln 325 330 335 Ser Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr 340 345 350 Val Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu 355 360 365 Arg Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val 370 375 380 Arg Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser 385 390 395 400 Tyr Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His 405 410 415 Thr Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val 420 425 430 Tyr Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln 435 440 445 Gln Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln 450 455 460 Lys Asn Leu Lys Gly Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala 465 470 475 480 Ser Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu 485 490 495 Arg Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe 500 505 510 Arg Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser 515 520 525 Ala Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro 530 535 540 Pro Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala 545 550 555 560 Tyr His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu 565 570 575 Cys His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys 580 585 590 Asn Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu 595 600 605 Gln Gly Pro Ser Asp Glu Gly Ser Ala Ala Lys Gly Gly Leu Lys Leu 610 615 620 Thr Pro Gly Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu 625 630 635 640 Asp Tyr His Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro 645 650 655 Pro Lys Ala Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu 660 665 670 Ala Gln Leu Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys 675 680 685 Lys Gly Arg Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn 690 695 700 Pro Gly Phe Pro Gln Asp Ala Pro Arg Lys Gln Glu Ala Glu Ser Gly 705 710 715 720 Ala Ala Ala Arg Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Gln Ser 725 730 735 Gly Arg Gly Gly Gly Asp Gly Gly Arg Leu Gly Gln His Ser Gly Arg 740 745 750 Gly Gly Gln Pro Ala Arg Gln Ser Gly Gly Arg Arg Gly Gly Gly Arg 755 760 765 Gly Gly Arg Ser Ser Arg Arg Gln Thr Val Val Leu Gly Gly Gly Glu 770 775 780 Ser Lys Gln His Gly Tyr His Leu Arg Ser Gly Ser Gly Ser Arg Ser 785 790 795 800 Ala Pro Gln <210> 163 <211> 227 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 163 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala Arg Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Ala Ala Thr 50 55 60 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 164 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 164 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Ala 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Ile Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Arg Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asn His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 165 <211> 176 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 165 Met Gly Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val Leu 1 5 10 15 Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu Glu Lys Ala 20 25 30 Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Val Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Ala His Met Cys Asn Thr Val Met Trp Met Ser Lys Gln Tyr Asp Met 115 120 125 Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Leu Cys Thr Ala Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 166 <211> 228 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 166 Met Arg Leu Leu Asn Phe Leu Asn Ile Val Leu Ser Ile Ala Tyr Ala 1 5 10 15 Ser Gly Tyr Ala Asn Ile Gln Lys Thr Leu Tyr Val Gly Ser Asp Gly 20 25 30 Thr Leu Glu Gly Thr Gln Ser Gln Ala Lys Val Ala Trp Tyr Phe Tyr 35 40 45 Arg Thr Asn Thr Asp Pro Val Lys Leu Cys Lys Gly Glu Leu Pro Arg 50 55 60 Thr His Lys Thr Pro Leu Thr Phe Ser Cys Ser Asn Asn Asn Leu Thr 65 70 75 80 Leu Phe Ser Ile Thr Lys Gln Tyr Thr Gly Thr Tyr Tyr Ser Thr Asn 85 90 95 Phe His Thr Gly Gln Asp Lys Tyr Tyr Thr Val Lys Val Glu Asn Pro 100 105 110 Thr Thr Pro Arg Thr Thr Thr Thr Thr Thr Thr Thr Ala Lys Pro Thr 115 120 125 Val Lys Thr Thr Thr Arg Thr Thr Thr Thr Thr Glu Thr Thr Thr Ser 130 135 140 Thr Thr Leu Ala Ala Thr Thr His Thr His Thr Lys Leu Thr Leu Gln 145 150 155 160 Thr Thr Asn Asp Leu Ile Ala Leu Leu Gln Lys Gly Asp Asn Ser Thr 165 170 175 Thr Ser Asn Glu Glu Ile Pro Lys Ser Met Ile Gly Ile Ile Val Ala 180 185 190 Val Val Val Cys Met Leu Ile Ile Ala Leu Cys Met Val Tyr Tyr Ala 195 200 205 Phe Cys Tyr Arg Lys His Arg Leu Asn Asp Lys Leu Glu His Leu Leu 210 215 220 Ser Val Glu Phe 225 <210> 167 <211> 203 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 167 Met Lys Ile Leu Gly Leu Phe Ser Phe Ser Ile Ile Thr Ser Ala Leu 1 5 10 15 Cys Glu Ser Val Asp Arg Asp Val Thr Ile Thr Thr Gly Ser Asn Tyr 20 25 30 Thr Leu Lys Gly Pro Pro Ser Gly Met Leu Ser Trp Tyr Cys Tyr Phe 35 40 45 Gly Thr Asp Thr Asp Gln Thr Glu Leu Cys Asn Phe Gln Lys Gly Lys 50 55 60 Thr Ser Asn Ser Lys Ile Ser Asn Tyr Gln Cys Asn Gly Thr Asp Leu 65 70 75 80 Ile Leu Leu Asn Val Thr Lys Ala Tyr Gly Gly Ser Tyr Tyr Cys Pro 85 90 95 Gly Gln Asn Thr Glu Glu Met Ile Phe Tyr Lys Val Glu Val Val Asp 100 105 110 Pro Thr Thr Pro Pro Thr Thr Thr Thr Ile His Thr Thr His Thr Glu 115 120 125 Gln Thr Pro Glu Ala Thr Glu Ala Glu Leu Ala Phe Gln Val His Gly 130 135 140 Asp Ser Phe Ala Val Asn Thr Pro Thr Pro Asp Gln Arg Cys Pro Gly 145 150 155 160 Pro Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly Leu Ala Val Ile 165 170 175 Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr Arg 180 185 190 Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 195 200 <210> 168 <211> 288 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 168 Met Lys Ala Val Ser Ala Leu Val Phe Cys Ser Leu Ile Asp Ile Val 1 5 10 15 Phe Asn Ser Lys Ile Thr Lys Val Ser Phe Ile Lys His Val Asn Val 20 25 30 Thr Glu Gly Asp Asn Ile Thr Leu Ala Gly Val Glu Gly Ala Gln Asn 35 40 45 Thr Thr Trp Thr Lys Tyr His Leu Gly Trp Arg Asp Ile Cys Thr Trp 50 55 60 Asn Val Thr Tyr Tyr Cys Ile Gly Ile Asn Leu Thr Ile Val Asn Ala 65 70 75 80 Asn Gln Ser Gln Asn Gly Leu Ile Lys Gly Gln Ser Val Ser Val Thr 85 90 95 Ser Asp Gly Tyr Tyr Thr Gln His Ser Phe Asn Tyr Asn Ile Thr Val 100 105 110 Ile Pro Leu Pro Thr Pro Ser Pro Pro Ser Thr Thr Thr Gln Thr Thr 115 120 125 Thr Tyr Ser Thr Ser Asn Gln Pro Thr Thr Thr Thr Ala Ala Glu Val 130 135 140 Ala Ser Ser Ser Gly Val Arg Val Ala Phe Leu Met Leu Ala Pro Ser 145 150 155 160 Ser Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Glu Phe Leu Ser 165 170 175 Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe Ser Ser Thr 180 185 190 Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro Ala Thr Thr 195 200 205 Pro Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys Gln Thr Asp Gly Gly 210 215 220 Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly Leu Val Ile Leu 225 230 235 240 Ala Val Leu Leu Tyr Tyr Ile Phe Cys Arg Arg Ile Pro Asn Ala His 245 250 255 Arg Lys Pro Ala Tyr Lys Pro Ile Val Ile Gly Gln Pro Glu Pro Leu 260 265 270 Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser Phe Thr Val Trp 275 280 285 <210> 169 <211> 144 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 169 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu Val Leu Pro Arg 1 5 10 15 Pro Val Asp Pro Arg Pro Pro Thr Gln Ser Pro Glu Glu Val Arg Lys 20 25 30 Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys 35 40 45 Ser Asp Met His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile 50 55 60 Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Cys Phe Asp Phe 65 70 75 80 Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr 85 90 95 Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Pro Pro Gln Pro 100 105 110 Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg 115 120 125 Pro Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 130 135 140 <210> 170 <211> 445 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 170 Met Ser Lys Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro Val Tyr 1 5 10 15 Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro 20 25 30 Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser 35 40 45 Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu 50 55 60 Lys Leu Gly Asp Gly Val Asp Leu Asp Asp Ser Gly Lys Leu Ile Ser 65 70 75 80 Asn Thr Ala Thr Lys Ala Ala Ala Pro Leu Ser Phe Ser Asn Asn Thr 85 90 95 Ile Ser Leu Asn Met Asp Thr Pro Leu Tyr Asn Asn Asn Gly Lys Leu 100 105 110 Gly Met Lys Val Thr Ala Pro Leu Lys Ile Leu Asp Thr Asp Leu Leu 115 120 125 Lys Thr Leu Val Val Ala Tyr Gly Gln Gly Leu Gly Thr Asn Thr Asn 130 135 140 Gly Ala Leu Val Ala Gln Leu Ala Tyr Pro Leu Val Phe Asn Thr Ala 145 150 155 160 Ser Lys Ile Ala Leu Asn Leu Gly Asn Gly Pro Leu Lys Val Asp Ala 165 170 175 Asn Arg Leu Asn Ile Asn Cys Lys Arg Gly Ile Tyr Val Thr Thr Thr 180 185 190 Lys Asp Ala Leu Glu Ile Asn Ile Ser Trp Ala Asn Ala Met Thr Phe 195 200 205 Ile Gly Asn Ala Ile Gly Val Asn Ile Asp Thr Lys Lys Gly Leu Gln 210 215 220 Phe Gly Thr Ser Ser Thr Glu Thr Asp Val Lys Asn Ala Phe Pro Leu 225 230 235 240 Gln Val Lys Leu Gly Ala Gly Leu Thr Phe Asp Ser Thr Gly Ala Ile 245 250 255 Val Ala Trp Asn Lys Glu Asp Asp Lys Leu Thr Leu Trp Thr Thr Ala 260 265 270 Asp Pro Ser Pro Asn Cys His Ile Tyr Ser Ala Lys Asp Ala Lys Leu 275 280 285 Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Ser 290 295 300 Leu Ile Ala Val Asp Thr Gly Ser Leu Asn Pro Ile Thr Gly Gln Val 305 310 315 320 Thr Thr Ala Leu Val Ser Leu Lys Phe Asp Ala Asn Gly Val Leu Gln 325 330 335 Thr Ser Ser Thr Leu Asp Lys Glu Tyr Trp Asn Phe Arg Lys Gly Asp 340 345 350 Val Thr Pro Ala Glu Pro Tyr Thr Asn Ala Ile Gly Phe Met Pro Asn 355 360 365 Ile Lys Ala Tyr Pro Lys Asn Thr Asn Ser Ala Ala Lys Ser His Ile 370 375 380 Val Gly Lys Val Tyr Leu His Gly Glu Val Ser Lys Pro Leu Asp Leu 385 390 395 400 Ile Ile Thr Phe Asn Glu Thr Ser Asn Glu Thr Cys Thr Tyr Cys Ile 405 410 415 Asn Phe Gln Trp Gln Trp Gly Thr Asp Lys Tyr Lys Asn Glu Thr Leu 420 425 430 Ala Val Ser Ser Phe Thr Phe Ser Tyr Ile Ala Gln Glu 435 440 445 <210> 171 <211> 31920 <212> DNA <213> Artificial Sequence <220> <223> Simian adenovirus A1331 clone <220> <221> CDS <222> (25539)..(26084) <223> 22K <220> <221> CDS <222> (27385)..(28008) <223> E3\CR1-alpha <220> <221> CDS <222> (31464)..(31868) <223> E3\14.7K <400> 171 aattatttaa atccwwymtm wataatatac ctcaaacttt tggtgcgcgt taatatgcaa 60 atgagccgtt tgaatttggg gatggaggaa ggtgattggc tgtgggagcg gcgaccgtta 120 ggggcggggc gggtgacgtt ttgatgacgt ggccatgagg cggagccggt ttgcaagttc 180 tcgtgggaaa agtgacgtca aacgaggtgt ggtttgaaca cggaaatact caattttccc 240 gcgctctctg acaggaaatg aggtgtttct gggcggatgc aagtgaaaac gggccatttt 300 cgcgcgaaaa ctgaatgagg aagtgaaaat ctgagtaatt ccgcgtttat ggcagggagg 360 agtatttgcc gagggccgag tagactttga ccgattacgt gggggtttcg attaccgtat 420 ttttcaccta aatttccgcg tacggtgtca aagtccggtg tttttacgta actataacgg 480 tcctaaggta gcgaaagctc agatctggat ctcccgatcc cctatggcga ctctcagtac 540 aatctgctct gatgccgcat agttaagcca gtatctgctc cctgcttgtg tgttggaggt 600 cgctgagtag tgcgcgagca aaatttaagc tacaacaagg caaggcttga ccgacaattg 660 catgaagaat ctgcttaggg ttaggcgttt tgcgctgctt cgcgatgtac gggccagata 720 tacgcgttga cattgattat tgactagtta ttaatagtaa tcaattacgg ggtcattagt 780 tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg 840 accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc 900 aatagggact ttccattgac gtcaatgggt ggactattta cggtaaactg cccacttggc 960 agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg 1020 gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat 1080 ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca tcaatgggcg 1140 tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag 1200 tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact ccgccccatt 1260 gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctcgtttagt 1320 gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata gaagacaccg 1380 ggaccgatcc agcctccgcg ggcgcgcgtc gacagagaga tgggtgcgag agcgtcagta 1440 ttaagcgggg gagaattaga tcgatgggaa aaaattcggt taaggccagg gggaaagaag 1500 aagtacaagc taaagcacat cgtatgggca agcagggagc tagaacgatt cgcagttaat 1560 cctggcctgt tagaaacatc agaaggctgt agacaaatac tgggacagct acaaccatcc 1620 cttcagacag gatcagagga gcttcgatca ctatacaaca cagtagcaac cctctattgt 1680 gtgcaccagc ggatcgagat caaggacacc aaggaagctt tagacaagat agaggaagag 1740 caaaacaagt ccaagaagaa ggcccagcag gcagcagctg acacaggaca cagcaatcag 1800 gtcagccaaa attaccctat agtgcagaac atccaggggc aaatggtaca tcaggccata 1860 tcacctagaa ctttaaatgc atgggtaaaa gtagtagaag agaaggcttt cagcccagaa 1920 gtgataccca tgttttcagc attatcagaa ggagccaccc cacaggacct gaacacgatg 1980 ttgaacaccg tggggggaca tcaagcagcc atgcaaatgt taaaagagac catcaatgag 2040 gaagctgcag attgggatag agtgcatcca gtgcatgcag ggcctattgc accaggccag 2100 atgagagaac caaggggaag tgacatagca ggaactacta gtacccttca ggaacaaata 2160 ggatggatga caaataatcc acctatccca gtaggagaga tctacaagag gtggataatc 2220 ctgggattga acaagatcgt gaggatgtat agccctacca gcattctgga cataagacaa 2280 ggaccaaagg aaccctttag agactatgta gaccggttct ataaaactct aagagctgag 2340 caagcttcac aggaggtaaa aaattggatg acagaaacct tgttggtcca aaatgcgaac 2400 ccagattgta agaccatcct gaaggctctc ggcccagcgg ctacactaga agaaatgatg 2460 acagcatgtc agggagtagg aggacccggc cataaggcaa gagttttgta gggatccact 2520 agttctagac tcgagggggg gcccggtacc tttaagacca atgacttaca aggcagctgt 2580 agatcttagc cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaaag 2640 aagacaagat aaaccgctga tcagcctcga ctgtgccttc tagttgccag ccatctgttg 2700 tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct 2760 aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg 2820 gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg 2880 cggtgggctc tatggcttct gaggcggaaa gaaccagcag atctgcagat ctgaattcat 2940 ctatgtcggg tgcggagaaa gaggtaatga aatggcacat atgctggcca ccgtgcatgt 3000 ggcctcgcac ccccgcaaga catggcccga gttcgagcac aacgtcatga cccgctgcaa 3060 tgtgcacctg ggctcccgcc gaggcatgtt catgccatac cagtgcaaca tgcaatttgt 3120 gaaggtgctg ctggagcccg atgccatgtc cagagtgagc ctggcggggg tgtttgacat 3180 gaatgtggag ctgtggaaaa ttctgagata tgatgaatcc aagaccaggt gccgggcctg 3240 cgaatgcgga ggcaagcacg ccaggcttca gcccgtgtgt gtggaggtga cggaggacct 3300 gcgacccgat catttggtgt tgtcctgcaa cgggacggag ttcggctcca gcggggaaga 3360 atctgactag agtgagtagt gtttgggggc gggtgggagc ctgcatgagg ggcagaatga 3420 ctaaaatctg tgtttttctg tgcagcagca tgagcggaag cgcctccttt gagggagggg 3480 tattcagccc ttatctgacg gggcgtctcc cctcctgggc gggagtgcgt cagaatgtga 3540 tgggatctac ggtggacggc cggcccgtgc agcccgcgaa ctcttcaacc ctgacctacg 3600 cgaccctgag ctcctcgtcc gtggacgcag ctgccgccgc agctgctgct tccgccgcca 3660 gcgccgtgcg cggaatggcc ctgggcgccg gctactacag ctctctggtg gccaactcga 3720 gttccaccaa taatcccgcc agcctgaacg aggagaagct gctgctgctg atggcccagc 3780 tcgaggccct gacccagcgc ctgggcgagc tgacccagca ggtggctcag ctgcaggcgg 3840 agacgcgggc cgcggttgcc acggtgaaaa ccaaataaaa aatgaatcaa taaataaacg 3900 gagacggttg ttgattttaa cacagagtct tgaatcttta tttgattttt cgcgcgcggt 3960 aggccctgga ccaccggtct cgatcattga gcacccggtg gatcttttcc aggacccggt 4020 agaggtgggc ttggatgttg aggtacatgg gcatgagccc gtcccggggg tggaggtagc 4080 tccattgcag ggcctcgtgc tcgggggtgg tgttgtaaat cacccagtca tagcaggggc 4140 gcagtgcgtg gtgctgcacg atgtccttga ggaggagact gatggccacg ggcagcccct 4200 tggtgtaggt gttgacgaac ctgttgagct gggagggatg catgcggggg gagatgagat 4260 gcatcttggc ctggatcttg agattggcga tgttcccgcc cagatcccgc cgggggttca 4320 tgttgtgcag gaccaccagc acggtgtatc cggtgcactt ggggaatttg tcatgcaact 4380 tggaagggaa ggcgtgaaag aatttggaga cgcccttgtg accgcccagg ttttccatgc 4440 actcatccat gatgatggcg atgggcccgt gggcggcggc ctgggcaaag acgtttcggg 4500 ggtcggacac atcgtagttg tggtcctggg tgagctcgtc ataggccatt ttaatgaatt 4560 tggggcggag ggtgcccgac tgggggacga aggtgccttc gatcccgggg gcgtagttgc 4620 cctcgcagat ctgcatctcc caggccttga gctcggaggg ggggatcatg tccacctgcg 4680 gggcgatgaa aaaaacggtt tccggggcgg gggagatgag ctgcgccgaa agcaggttcc 4740 ggagcagctg ggacttgccg cagccggtgg ggccgtagat gaccccgatg accggctgca 4800 ggtggtagtt gagggagaga cagctgccgt cctcgcgtag gaggggggcc acctcgttca 4860 tcatctcgcg cacatgcatg ttctcgcgca cgagttccgc caggaggcgc tcgcccccca 4920 gcgagaggag ctcttgcagc gaggcgaagt ttttcagcgg cttgagcccg tcggccatgg 4980 gcattttgga gagggtctgt tgcaagagtt ccagacggtc ccagagctcg gtgatgtgct 5040 ctacggcatc tcgatccagc agacctcctc gtttcgcggg ttgggacgac tgcgggagta 5100 gggcaccaga cgatgggcgt ccagcgcagc cagggtccgg tccttccagg gtcgcagcgt 5160 ccgcgtcagc gtggtctccg tcacggtgaa ggggtgcgcg ccgggctggg cgcttgcgag 5220 ggtgcgcttc aggctcatcc ggctggtcga gaaccgctcc cgatcggcgc cctgcgcgtc 5280 ggccaggtag caattgacca tgagttcgta gttgagcgcc tcggccgcgt ggcctttggc 5340 gcggagctta cctttggaag tctgcccgca ggcgggacag aggagggact tgagggcgta 5400 gagcttgggg gcgaggaaga cggactcggg ggcgtaggcg tccgcgccgc agtgggcgca 5460 gacggtctcg cactccacaa gccaggtgag gtcgggctgg tcggggtcaa aaaccagttt 5520 tccgccgttc tttttgatgc gtttcttacc tttggtctcc atgagctcgt gtccccgctg 5580 ggtgacaaag aggctgtccg tgtccccgta gaccgacttt atgggccggt cctcgagcgg 5640 tgtgccacgg tcctcctcgt agaggaaccc cgcccactcc gagacgaaag cccgggtcca 5700 ggccagcacg aaggaggcca cgtgggacgg gtagcggtcg ttgtccacca gcgggtccac 5760 tttctccagg gtatgcaaac acatgtcccc ctcgtccaca tccaggaagg tgattggctt 5820 gtaagtgtag gccacgtgac cgggggtccc ggccgggggg gtataaaagg gggcgggccc 5880 ctgctcgtcc tcactgtctt ccggatcgct gtccaggagc gccagctgtt ggggtaggta 5940 ttccctctcg aaggcgggca tgacctcggc actcaggttg tcagtttcta gaaacgagga 6000 ggatttgata ttgacggtgc cgttggagac gcctttcatg agcccctcgt ccatctggtc 6060 agaaaagacg atctttttgt tgtcgagctt ggtggcgaag gagccgtaga gggcgttgga 6120 gagcagcttg gcgatggagc gcatggtctg gttcttttcc ttgtcggcgc gctccttggc 6180 ggcgatgttg agctgcacgt actcgcgcgc cacgcacttc cattcgggga agacggtggt 6240 gagctcgtcg ggcacgattc tgacccgcca gccgcggttg tgcagggtga tgaggtccac 6300 gctggtggcc acctcgccgc gcaggggctc gttggtccag cagaggcgcc cgcccttgcg 6360 cgagcagaag gggggcagcg ggtccagcat gagctcgtcg ggggggtcgg cgtccacggt 6420 gaagatgccg ggcaggagct cggggtcgaa gtagctgatg caggtgccca gatcgtccag 6480 cgccgcttgc cagtcgcgca cggccagcgc gcgctcgtag gggctgaggg gcgtgcccca 6540 gggcatgggg tgcgtgagcg cggaggcgta catgccgcag atgtcgtaga cgtagagggg 6600 ctcctcgagg acgccgatgt aggtggggta gcagcgcccc ccgcggatgc tggcgcgcac 6660 gtagtcgtac agctcgtgcg agggcgcgag gagccccgcg ccgaggttgg agcgctgcgg 6720 cttttcggcg cggtagacga tctggcggaa gatggcgtgg gagttggagg agatggtggg 6780 cctctggaag atgttgaagt gggcgtgggg caggccgacc gagtccctga tgaagtgggc 6840 gtaggagtcc tgcagcttgg cgacgagctc ggcggtgacg aggacgtcca gggcgcagta 6900 gtcgagggtc tcttggatga tgtcgtactt gagctggccc ttctgcttcc acagctcgcg 6960 gttgagaagg aactcttcgc ggtccttcca gtactcttcg agggggaacc cgtcctgatc 7020 ggcacggtaa gagcccacca tgtagaactg gttgacggcc ttgtaggcgc agcagccctt 7080 ctccacgggg agggcgtaag cttgcgcggc cttgcgcagg gaggtgtggg tgagggcgaa 7140 ggtgtcgcgc accatgacct tgaggaactg gtgcttgaag tcgaggtcgt cgcagccgcc 7200 ctgctcccag agttggaagt ccgtgcgctt cttgtaggcg gggttgggca aagcgaaagt 7260 aacatcgttg aagaggatct tgcccgcgcg gggcatgaag ttgcgagtga tgcggaaagg 7320 ctggggcacc tcggcccggt tgttgatgac ctgggcggcg aggacgatct cgtcgaagcc 7380 gttgatgttg tgcccgacga tgtagagttc cacgaatcgc gggcggccct tgacgtgggg 7440 cagcttcttg agctcgtcgt aggtgagctc ggcggggtcg ctgagcccgt gctgctcaag 7500 ggcccagtcg gcgacgtggg ggttggcgct gaggaaggaa gtccagagat ccacggccag 7560 ggcggtttgc aagcggtccc ggtactgacg gaactgctgg cccacggcca ttttttcggg 7620 ggtgatgcag tagaaggtgc gggggtcgcc gtgccagcgg tcccacttga gctggagggc 7680 gaggtcgtgg gcgagctcga cgagcggcgg gtccccggag agtttcatga ccagcatgaa 7740 ggggacgagc tgcttgccga aggaccccat ccaggtgtag gtttccacat cgtaggtgag 7800 gaagagcctt tcggtgcgag gatgcgagcc gatggggaag aactggatct cctgccacca 7860 gttggaggaa tggctgttga tgtgatggaa gtagaaatgc cgacggcgcg ccgagcactc 7920 gtgcttgtgt ttatacaagc gtccgcagtg ctcgcaacgc tgcacgggat gcacgtgctg 7980 cacgagctgt acctgggttc ctttgacgag gaatttcagt gggcagtgga gcgctggcgg 8040 ctgcatctgg tgctgtacta cgtcctggcc atcggcgtgg ccatcgtctg cctcgatggt 8100 ggtcatgctg acgagcccgc gcgggaggca ggtccagacc tcggctcgga cgggtcggag 8160 agcgaggacg agggcgcgca ggccggagct gtccagggtc ctgagacgct gcggagtcag 8220 gtcagtgggc agcggcggcg cgcggttgac ttgcaggagc ttttccaggg cgcgcgggag 8280 gtccagatgg tacttgatct ccacggcgcc gttggtggcg acgtccacgg cttgcagggt 8340 cccgtgcccc tggggcgcca ccaccgtgcc ccgtttcttc ttgggcgctg gcgttggcgc 8400 tgcttccatg tcggtcagaa gcggcggcga ggacgcgcgc cgggcggcag gggcggctcg 8460 gggcccggag gcaggggcgg caggggcacg tcggcgccgc gcgcgggcag gttctggtac 8520 tgcgcccgga gaagactggc gtgagcgacg acgcgacggt tgacgtcctg gatctgacgc 8580 ctctgggtga aggccacggg acccgtgagt ttgaacctga aagagagttc gacagaatca 8640 atctcggtat cgttgacggc ggcctgccgc aggatctctt gcacgtcgcc cgagttgtcc 8700 tggtaggcga tctcggtcat gaactgctcg atctcctcct cctgaaggtc tccgcggccg 8760 gcgcgctcga cggtggccgc gaggtcgttg gagatgcggc ccatgagctg cgagaaggcg 8820 ttcatgccgg cctcgttcca gacgcggctg tagaccacgg atccgtcggg gtcgcgcgcg 8880 cgcatgacca cctgggcgag gttgagctcc acgtggcgcg tgaagaccgc gtagttgcag 8940 aggcgctggt agaggtagtt gagcgtggtg gcgatgtgct cggtgacgaa gaagtacatg 9000 atccagcggc ggagcggcat ctcgctgacg tcgcccaggg cttccaagcg ctccatggcc 9060 tcgtagaagt ccacggcgaa gttgaaaaac tgggagttgc gcgccgagac ggtcaactcc 9120 tcctccagaa gacggatgag ctcggcgatg gtggcgcgca cctcgcgctc gaaggccccg 9180 gggggctcct cttccatctc ctcctcttct tcctcctcca ctaacatctc ttctacttcc 9240 tcctcaggag gcggcggcgg gggagggggc ctgcgtcgcc ggcggcgcac gggcagacgg 9300 tcgatgaagc gctcgatggt ctccccgcgc cggcgacgca tggtctcggt gacggcgcgc 9360 ccgtcctcgc ggggccgcag cgtgaagacg ccgccgcgca tctccaggtg gccgccgggg 9420 gggtctccgt tgggcaggga gagggcgctg acgatgcatc ttatcaattg acccgtaggg 9480 actccgcgca aggacctgag cgtctcgaga tccacgggat ccgaaaaccg ctgaacgaag 9540 gcttcgagcc agtcgcagtc gcaaggtagg ctgagcccgg tttcttcttc ggggatttgc 9600 tggtcgggag gcgggcgggc gatgctgctg gtgatgaagt tgaagtaggc ggtcctgaga 9660 cggcggatgg tggcgaggag caccaggtcc ttgggcccgg cttgctggat gcgcagacgg 9720 tcggccatgc cccaggcgtg gtcctgacac ctggcgaggt ccttgtagta gtcctgcatg 9780 agccgctcca cgggcacctc ctcctcgccc gcgcggccgt gcatgcgcgt gagcccgaac 9840 ccgcgctggg gctggacgag cgccaggtcg gcgacgacgc gctcggcgag gatggcctgc 9900 tggatctggg tgagggtggt ctggaagtcg tcgaagtcga cgaagcggtg gtaggctccg 9960 gtgttgatgg tgtaggagca gttggccatg acggaccagt tgacggtctg gtggccgggg 10020 cgcacgagct cgtggtactt gaggcgcgag taggcgcgcg tgtcgaagat gtagtcgttg 10080 caggtgcgca cgaggtactg gtatccgacg aggaagtgag gcggcggctg gcggtagagc 10140 ggccatcgct cggtggcggg ggcgccgggc gcgaggtctt cgagcatgag gcggtggtag 10200 ccgtagatgt acctggacat ccaggtgatg ccagcggcgg tggtggaggc gcgcgggaac 10260 tcgcggacgc ggttccagat gttgcgcagc ggcaggaagt agttcatggt ggccgcggtc 10320 tggcccgtga ggcgcgcgca gtcgtggatg ctctagacat acgggcaaaa acgaaagcgg 10380 tcagcggctc gactccgtgg cctggaggct aagcgaacgg gttgggctgc gcgtgtaccc 10440 cggttcgagt ccctgctcga atcaggctgg agccgcagct aacgtggtac tggcactccc 10500 gtctcgaccc aagcctgcta acgaaacctc caggatacgg aggcgggtcg ttttttggcc 10560 ttggtcactg gtcatgaaaa actagtaagc gcggaaagcg gccgcccgcg atggctcgct 10620 gccgtagtct ggagaaagaa tcgccagggt tgcgttgcgg tgtgccccgg ttcgagcctc 10680 agcgctcggc gccggccgga ttccgcggct aacgtgggcg tggctgcccc gtcgtttcca 10740 agacccctta gccagccgac ttctccagtt acggagcgag cccctctttt tcttgtgttt 10800 ttgccagatg catcccgtac tgcggcagat gcgcccccac cctccacctc aaccgcccct 10860 accgcagcag cagcaacagc cggcgctttt gcccccgccc cagcagcagc agcagccagc 10920 cactaccgcg gcggccgccg tgagcggagc cggcgttcaa tatgacctgg ccttggaaga 10980 gggcgagggg ctggcgcggc tgggggcgtc gtcgccggag cggcacccgc gcgtgcagat 11040 gaaaagggac gctcgcgagg cctacgtgcc caagcagaac ctgttcagag acaggagcgg 11100 cgaggagccc gaggagatgc gcgcctcccg cttccacgcg gggcgggagc tgcggcgcgg 11160 cctggaccga aagcgggtgc tgagggacga ggatttcgag gcggacgagc tgacggggat 11220 cagccccgcg cgcgcgcacg tggccgcggc caacctggtc acggcgtacg agcagaccgt 11280 gaaggaggag agcaacttcc aaaaatcctt caacaaccac gtgcgcacgc tgatcgcgcg 11340 cgaggaggtg accctgggcc tgatgcacct gtgggacctg ctggaggcca tcgtgcagaa 11400 ccccacgagc aagccgctga cggcgcagct gttcctggtg gtgcagcaca gtcgggacaa 11460 cgagacgttc agggaggcgc tgctgaatat caccgagccc gagggccgct ggctcctgga 11520 cctggtgaac attctgcaga gcatcgtggt gcaggagcgc gggctgccgc tgtccgagaa 11580 gctggcggcc atcaacttct cggtgctgag cctgggcaag tactacgcta ggaagatcta 11640 caagaccccg tacgtgccca tagacaagga ggtgaagatc gatgggtttt acatgcgcat 11700 gaccctgaaa gtgctgaccc tgagcgacga tctgggggtg taccgcaacg acaggatgca 11760 ccgcgcggtg agcgccagcc gccggcgcga gctgagcgac caggagctga tgcacagcct 11820 gcagcgggcc ctgaccgggg ccgggaccga gggggagagc tactttgaca tgggcgcgga 11880 cctgcgctgg cagcccagcc gccgggcctt ggaagctgcc ggcggcgtgc cctacgtgga 11940 ggaggtggac gatgaggagg aggagggcga gtacctggaa gactgatggc gcgaccgtat 12000 ttttgctaga tgcagcaaca gccaccgcct cctgatcccg cgatgcgggc ggcgctgcag 12060 agccagccgt ccggcattaa ctcctcggac gattggaccc aggccatgca acgcatcatg 12120 gcgctgacga cccgcaatcc cgaagccttt agacagcagc ctcaggccaa ccggctctcg 12180 gccatcctgg aggccgtggt gccctcgcgc tcgaacccca cgcacgagaa ggtgctggcc 12240 atcgtgaacg cgctggtgga gaacaaggcc atccgcggcg acgaggccgg gctggtgtac 12300 aacgcgctgc tggagcgcgt ggcccgctac aacagcacca acgtgcagac gaacctggac 12360 cgcatggtga ccgacgtgcg cgaggcggtg tcgcagcgcg agcggttcca ccgcgagtcg 12420 aacctgggct ccatggtggc gctgaacgcc ttcctgagca cgcagcccgc caacgtgccc 12480 cggggccagg aggactacac caacttcatc agcgcgctgc ggctgatggt ggccgaggtg 12540 ccccagagcg aggtgtacca gtcggggccg gactacttct tccagaccag tcgccagggc 12600 ttgcagaccg tgaacctgag ccaggctttc aagaacttgc agggactgtg gggcgtgcag 12660 gccccggtcg gggaccgcgc gacggtgtcg agcctgctga cgccgaactc gcgcctgctg 12720 ctgctgctgg tggcgccctt cacggacagc ggcagcgtga gccgcgactc gtacctgggc 12780 tacctgctta acctgtaccg cgaggccatc gggcaggcgc acgtggacga gcagacctac 12840 caggagatca cccacgtgag ccgcgcgctg ggccaggagg acccgggcaa cctggaggcc 12900 accctgaact tcctgctgac caaccggtcg cagaagatcc cgccccagta cgcgctgagc 12960 accgaggagg agcgcatcct gcgctacgtg cagcagagcg tggggctgtt cctgatgcag 13020 gagggggcca cgcccagcgc cgcgctcgac atgaccgcgc gcaacatgga gcccagcatg 13080 tacgcccgca accgcccgtt catcaataag ctgatggact acttgcatcg ggcggccgcc 13140 atgaactcgg actactttac caacgccatc ttgaacccgc actggctccc gccgcccggg 13200 ttctacacgg gcgagtacga catgcccgac cccaacgacg ggttcctgtg ggacgacgtg 13260 gacagcagcg tgttctcgcc gcgccccacc accaccgtgt ggaagaaaga gggcggggac 13320 cggcggccgt cctcggcgct gtccggtcgc gcgggtgctg ccgcggcggt gcccgaggcc 13380 gccagcccct tcccgagcct gcccttttcg ctgaacagcg tgcgcagcag cgatctgggt 13440 cggctgacgc ggccgcgcct gctgggcgag gaggagtacc tgaacgactc cttgttgagg 13500 cccgagcgcg agaaaaactt ccccaataac gggatagaga gcctggtgga caagatgagc 13560 cgctggaaga cgtacgcgca cgagcacagg gacgagcccc gagctagcag cagcaccggc 13620 gcccgtagac gccagcggca cgacaggcag cggggactgg tgtgggacga tgaggattcc 13680 gccgacgaca gcagcgtgtt ggacttgggt gggagtggtg gtggtaaccc gttcgctcac 13740 ctgcgccccc gtatcgggcg cctgatgtaa gaatctgaaa aaataaaaaa acggtactca 13800 ccaaggccat ggcgaccagc gtgcgttctt ctctgttgtt tgtagtagta tgatgaggcg 13860 cgtgtacccg gagggtcctc ctccctcgta cgagagcgtg atgcagcagg cggtggcggc 13920 ggcgatgcag cccccgctgg aggcgcctta cgtgcccccg cggtacctgg cgcctacgga 13980 ggggcggaac agcattcgtt actcggagct ggcacccttg tacgatacca cccggttgta 14040 cctggtggac aacaagtcgg cggacatcgc ctcgctgaac taccagaacg accacagcaa 14100 cttcctgacc accgtggtgc agaacaacga tttcaccccc acggaggcca gcacccagac 14160 catcaacttt gacgagcgct cgcggtgggg cggccagctg aaaaccatca tgcacaccaa 14220 catgcccaac gtgaacgagt tcatgtacag caacaagttc aaggcgcggg tgatggtctc 14280 gcgcaagacc cccaacgggg tcacagtaac agatggtagt caggacgagc tgacctacga 14340 gtgggtggag tttgagctgc ccgagggcaa cttctcggtg accatgacca tcgatctgat 14400 gaacaacgcc atcatcgaca actacttggc ggtgggacgg cagaacgggg tgctggagag 14460 cgacatcggc gtgaagttcg acacgcgcaa cttccggctg ggctgggacc ccgtgaccga 14520 gctggtgatg ccgggcgtgt acaccaacga ggccttccac cccgacatcg tcctgctgcc 14580 cggctgcggc gtggacttca ccgagagccg cctcagcaac ctgctgggca tccgcaagcg 14640 gcagcccttc caggagggct tccagatcct gtacgaggac ctggaggggg gcaacatccc 14700 cgcgctgctg gacgtcgaag cctacgagaa aagcaaggag gaggccgccg cagcggcgac 14760 cgcggccgtg gctaccgctg cgaccaccga tgcagatgca gctactacta ccaggggcga 14820 tacattcgcc acccaggcgg aggaagcagc cgccctagcg gcgaccgatg atagtgaaag 14880 taagatagtc atcaagccgg tggagaagga cagcaaggac aggagctaca acgttctatc 14940 ggatggaaag aacaccgcct accgcagctg gtacctggcc tacaactacg gcgaccctga 15000 gaagggcgtg cgctcctgga cgctgctcac cacctcggac gtcacctgcg gcgtggagca 15060 agtctactgg tcgctgcccg acatgatgca agacccggtc accttccgct ccacgcgtca 15120 agttagcaac tacccggtgg tgggcgccga gctcctgccc gtctactcca agagcttctt 15180 caacgagcag gccgtctact cgcagcagct gcgcgccttc acctcgctca cgcacgtctt 15240 caaccgcttc cccgagaacc agatcctcgt ccgcccgccc gcgcccacca ttaccaccgt 15300 cagtgaaaac gttcctgctc tcacagatca cgggaccctg ccgctgcgca gcagtatccg 15360 gggagtccag cgcgtgaccg tcactgacgc cagacgccgc acctgcccct acgtctacaa 15420 ggccctgggc gtagtcgcgc cgcgcgtcct ctcgagccgc accttctaaa aaatgtccat 15480 tctcatctcg cccagtaata acaccggttg gggcctgcgc gcgcccagca agatgtacgg 15540 aggcgctcgc caacgctcca cgcaacaccc cgtgcgcgtg cgcgggcact tccgcgctcc 15600 ctggggcgcc ctcaagggcc gcgtgcgctc gcgcaccacc gtcgacgacg tgatcgacca 15660 ggtggtggcc gacgcgcgca actacacgcc cgccgccgcg cccgcctcca ccgtggacgc 15720 cgtcatcgac agcgtggtgg ccgacgcgcg ccggtacgcc cgcgccaaga gccggcggcg 15780 gcgcatcgcc cggcggcacc ggagcacccc cgccatgcgc gcggcgcgag ccttgctgcg 15840 cagggccagg cgcacgggac gcagggccat gctcagggcg gccagacgcg cggcctccgg 15900 cagcagcagc gccggcagga cccgcagacg cgcggccacg gcggcggcgg cggccatcgc 15960 cagcatgtcc cgcccgcggc gcggcaacgt gtactgggtg cgcgacgccg ccaccggtgt 16020 gcgcgtgccc gtgcgcaccc gcccccctcg cacttgaaga tgctgacttc gcgatgttga 16080 tgtgtcccag cggcgaggag gatgtccaag cgcaaattca aggaagagat gctccaggtc 16140 atcgcgcctg agatctacgg ccccgcggcg gcggtgaagg aggaaagaaa gccccgcaaa 16200 ctgaagcggg tcaaaaagga caaaaaggag gaggaagatg acggactggt ggagtttgtg 16260 cgcgagttcg ccccccggcg gcgcgtgcag tggcgcgggc ggaaagtgaa accggtgctg 16320 cggcccggca ccacggtggt cttcacgccc ggcgagcgtt ccggctccgc ctccaagcgc 16380 tcctacgacg aggtgtacgg ggacgaggac atcctcgagc aggcggcaga gcgtctgggc 16440 gagtttgctt acggcaagcg cagccgcccc gcgcccttga aagaggaggc ggtgtccatc 16500 ccgctggacc acggcaaccc cacgccgagc ctgaagccgg tgaccctgca gcaggtgctg 16560 ccgagcgcgg cgccgcgccg gggcttcaag cgcgagggcg gcgaggatct gtacccgacc 16620 atgcagctga tggtgcccaa gcgccagaag ctggaggacg tgctggagca catgaaggtg 16680 gaccccgagg tgcagcccga ggtcaaggtg cggcccatca agcaggtggc cccgggcctg 16740 ggcgtgcaga ccgtggacat caagatcccc acggagccca tggaaacgca gaccgagccc 16800 gtgaagccca gcaccagcac catggaggtg cagacggatc cctggatgcc ggcgccggct 16860 tccaccacca ctcgccgaag acgcaagtac ggcgcggcca gcctgctgat gcccaactac 16920 gcgctgcatc cttccatcat ccccacgccg ggctaccgcg gcacgcgctt ctaccgcggc 16980 tacagcagcc gccgcaagac caccacccgc cgccgccgtc gccgcacccg ccgcagcacc 17040 accgcgactt ccgccgccgc cttggtgcgg agagtgtacc gcagcgggcg tgagcctctg 17100 accctgccgc gcgcgcgcta ccacccgagc atcgccattt aactctgccg tcgcctcctt 17160 gcagatatgg ccctcacatg ccgcctccgc gtccccatta cgggctaccg aggaagaaag 17220 ccgcgccgta gaaggctgac ggggaacggg ctgcgtcgcc atcaccaccg gcggcggcgc 17280 gccatcagca agcggttggg gggaggcttc ctgcccgcgc tgatccccat catcgccgcg 17340 gcgatcgggg cgatccccgg catagcttcc gtggcggtgc aggcctctca gcgccactga 17400 gacacagctt ggaaaatttg taataaaaaa atggactgac gctcctggtc ctgtgatgtg 17460 tgtttttaga tggaagacat caatttttcg tccctggcac cgcgacacgg cacgcggccg 17520 tttatgggca cctggagcga catcggcaac agccaactga acgggggcgc cttcaattgg 17580 agcagtctct ggagcgggct taagaatttc gggtccacgc tcaaaaccta tggcaacaag 17640 gcgtggaaca gcagcacagg gcaggcgctg agggaaaagc tgaaagagca gaacttccag 17700 cagaaggtgg tcgatggcct ggcctcgggc atcaacgggg tggtggacct ggccaaccag 17760 gccgtgcaga aacagatcaa cagccgcctg gacgcggtcc cgcccgcggg gtccgtggag 17820 atgccccagg tggaggagga gctgcctccc ctggacaagc gcggcgacaa gcgaccgcgt 17880 cccgacgcgg aggagacgct gctgacgcac acggacgagc cgcccccgta cgaggaggcg 17940 gtgaaactgg gtctgcccac cacgcggccc atcgcgcccc tggccaccgg ggtgctgaaa 18000 cccgagtcta agcccgcgac cctggacttg cctcctcccc cgacctcccg cccctccaca 18060 gtggctaagc ccctgccgcc ggtggcccgc gcgcgacccg ggagccgccc gcaggcgaac 18120 tggcagagca ctctgaacag catcgtgggt ctgggagtgc agagtgtgaa gcgccgccgc 18180 tgctattaaa cataccgtag cgcttaactt gcttgtctgt gtgtgtatgt attatgtcgc 18240 cgccgctgtc cagaaggagg agtgaagagg cgcgtcgccg agttgcaaga tggccacccc 18300 atcgatgctg ccccagtggg cgtacatgca catcgccgga caggacgctt cggagtacct 18360 gagtccgggt ctggtgcagt tcgcccgcgc cacagacacc tacttcagtc tggggaacaa 18420 gtttaggaac cccacggtgg cgcccacgca cgatgtgacc accgaccgca gccagcggct 18480 gacgctgcgc ttcgtgcccg tggaccgcga ggacaacacc tactcgtaca aagtgcgcta 18540 cacgctggcc gtgggcgaca accgcgtgct ggacatggcc agcacctact ttgacatccg 18600 cggcgtgctg gaccggggcc ctagcttcaa accctactcc ggcaccgcct acaacagcct 18660 ggcccccaag ggagctccca attccagtca gtgggagcag acggagaacg ggggcggaca 18720 ggctacgact aaaacacaca cctatggagt tgccccaatg ggtggaacta atattacagt 18780 cgacggacta caaattggaa ctgacgctac agctgatacg gaaaaaccaa tttatgctga 18840 taaaacattc caacctgagc ctcagatagg agaggaaaac tggcaagaaa ctgaaagctt 18900 ttatggcggt agggctctta agaaagacac aaacatgaag ccttgttatg gctcatttgc 18960 cagacctacc aatgaaaagg gaggtcaagc taaacttaaa gttggagctg atgggctgcc 19020 gaccaaagaa tttgacatag acctagcatt ctttgatact cctggtggca ctgtgaccgg 19080 aggtacagag gagtataaag cagatattgt tatgtatacc gaaaacacgt atctggaaac 19140 tccagacaca catgtggtgt ataaaccagg caaggataac acaagttcta aaattaacct 19200 ggtccagcag tctatgccca acaggcccaa ctacattggg tttagggaca actttattgg 19260 gctcatgtat tacaacagca ctggcaatat gggtgtgctg gccggtcagg cttctcagtt 19320 gaatgctgtg gttgacttgc aagacagaaa cactgaactg tcttaccagc tcttgcttga 19380 ctctttgggt gacagaacca ggtatttcag tatgtggaat caggcggtgg acagttatga 19440 tcctgatgtg cgcattattg aaaaccatgg tgtggaagat gaacttccca actattgctt 19500 ccccctggat gggtctggca ctaacgccgc ttaccaaggt gtgaaagtaa aaaatggtca 19560 agatggtgat gttgagagcg aatgggaaaa agatgatact gtcgcagctc gaaatcaatt 19620 atgcaagggc aacatttttg ccatggagat caatctccag gccaacctgt ggagaagttt 19680 tctctactcg aacgtggccc tgtacctgcc cgattcttac aagtacacgc cggccaacat 19740 caccctgccc accaacacca acacctacga ttacatgaac gggagagtgg tgcctccctc 19800 gctggtggac gcctacatca acatcggggc gcgctggtcg ctggacccca tggacaacgt 19860 caatcccttc aaccaccatc gcaacgcggg gctgcgctac cgctccatgc tcctgggcaa 19920 cgggcgctac gtgcccttcc acatccaggt gccccagaaa tttttcgcca ttaagagcct 19980 cctgctcctg cccgggtcct acacctacga gtggaacttc cgcaaggacg tcaacatgat 20040 cctgcagagc tccctcggca acgacctgcg cacggacggg gcctccatct ccttcaccag 20100 catcaacctc tacgccacct tcttccccat ggcgcacaac accgcctcca cgctcgaggc 20160 catgctgcgc aacgacacca acgaccagtc cttcaacgac tacctctcgg cggccaacat 20220 gctctacccc atcccggcca acgccaccaa cgtgcccatc tccatcccct cgcgcaactg 20280 ggccgccttc cgcggctggt ccttcacgcg cctcaagacc aaggagacgc cctcgctggg 20340 ctccgggttc gacccctact tcgtctactc gggctccatc ccctacctcg acggcacctt 20400 ctacctcaac cacaccttca agaaggtctc catcaccttc gactcctccg tcagctggcc 20460 cggcaacgac cggctcctga cgcccaacga gttcgaaatc aagcgcaccg tcgacggcga 20520 gggctacaac gtggcccagt gcaacatgac caaggactgg ttcctggtcc agatgctggc 20580 ccactacaac atcggctacc agggcttcta cgtgcccgag ggctacaagg accgcatgta 20640 ctccttcttc cgcaacttcc agcccatgag ccgccaggtg gtggacgagg tcaactacaa 20700 ggactaccag gccgtcaccc tggcctacca gcacaacaac tcgggcttcg tcggctacct 20760 cgcgcccacc atgcgccagg gccagcccta ccccgccaac tacccgtacc cgctcatcgg 20820 caagagcgcc gtcaccagcg tcacccagaa aaagttcctc tgcgacaggg tcatgtggcg 20880 catccccttc tccagcaact tcatgtccat gggcgcgctc accgacctcg gccagaacat 20940 gctctatgcc aactccgccc acgcgctaga catgaatttc gaagtcgacc ccatggatga 21000 gtccaccctt ctctatgttg tcttcgaagt cttcgacgtc gtccgagtgc accagcccca 21060 ccgcggcgtc atcgaggccg tctacctgcg cacccccttc tcggccggta acgccaccac 21120 ctaagctctt gcttcttgca agatggctga gcccacgggc tccggcgagc aggagctcag 21180 ggccatcatc cgcgacctgg gctgcgggcc ctacttcctg ggcaccttcg ataagcgctt 21240 cccgggattc atggccccgc acaagctggc ctgcgccatc gtcaacacgg ccggccgcga 21300 gaccgggggc gagcactggc tggccttcgc ctggaacccg cgctcgaaca cctgctacct 21360 cttcgacccc ttcgggttct cggacgagcg cctcaagcag atctaccagt tcgagtacga 21420 gggcctgctg cgccgcagcg ccctggccac cgaggaccgc tgcgtcaccc tggaaaagtc 21480 cacccagacc gtgcagggtc cgcgctcggc cgcctgcggg ctcttttgct gcatgttcct 21540 gcacgccttc gtgcactggc ccgaccgccc catggacaag aaccccacca tgaacttgct 21600 gacgggggtg cccaacggca tgctccagtc gccccaggtg gaacccaccc tgcgccgcaa 21660 ccaggaggcg ctctaccgct tcctcaacgc ccactccgcc tactttcgct cccaccgcgc 21720 gcgcatcgag aaggccaccg ccttcgaccg catgaatcaa gacatgtaaa ccgtgtgtgt 21780 gtatgttaaa atgtctttaa taaacagcac tttcatgtta cacatgcatc tgagatgatt 21840 tatttagaaa tcgaaagggt tctgccgggt ctcggcatgg cccgcgggca gggacacgtt 21900 gcggaactgg tacttggcca gccacttgaa ctcggggatc agcagtttcg gcagcggggt 21960 gtcggggaag gagtcggtcc acagcttccg cgtcagttgc agggcgccca gcaggtcggg 22020 cgcggagatc ttgaaatcgc agttgggacc cgcgttctgc gcgcgagagt tgcggtacac 22080 ggggttgcag cactggaaca ccatcagggc cgggtgcttc acgctcgcca gcaccgtcgc 22140 gtcggtgatg ccctccacgt ccagatcctc ggcgttggcc atcccgaagg gggtcatctt 22200 gcaggtctgc cgccccatgc tgggcacgca gccgggcttg tggttgcaat cgcagtgcag 22260 ggggatcagc atcatctggg cctgctcgga gctcatgccc gggtacatgg ccttcatgaa 22320 agcctccagc tggcggaagg cctgctgcgc cttgccgccc tcggtgaaga agaccccgca 22380 ggacttgcta gagaactggt tggtagcgca gcccgcgtcg tgcacgcagc agcgcgcgtc 22440 gttgttggcc agctgcacca cgctgcgccc ccagcggttc tgggtgatct tggcccggtc 22500 ggggttctcc ttcagcgcgc gctgcccgtt ctcgctcgcc acatccatct cgatcgtgtg 22560 ctccttctgg atcatcacgg tcccgtgcag gcaccgcagc ttgccctcgg cctcggtgca 22620 gccgtgcagc cacagcgcgc agccggtgct ctcccagttc ttgtgggcga tctgggagtg 22680 cgagtgcacg aagccctgca ggaagcggcc catcatcgcg gtcagggtct tgttgctggt 22740 gaaggtcagc gggatgccgc ggtgctcctc gttcacatac aggtggcaga tgcggcggta 22800 cacctcgccc tgctcgggca tcagctggaa ggcggacttc aggtcgctct ccacgcggta 22860 ccggtccatc agcagcgtca tcacttccat gcccttctcc caggccgaga cgatcggcag 22920 gctcaggggg ttcttcaccg ccattgtcat cttagtcgcc gccgccgagg tcagggggtc 22980 gttctcgtcc agggtctcaa acactcgctt gccgtccttc tcgatgatgc gcacgggggg 23040 aaagctgaag cccacggccg ccagctcctc ctcggcctgc ctttcgtcct cgctgtcctg 23100 gctgatgtct tgcaaaggca catgcttggt cttgcggggt ttctttttgg gcggcagagg 23160 cggcggcgat gtgctgggcg agcgcgagtt ctcgctcacc acgactattt cttctccttg 23220 gccgtcgtcc gagaccacgc ggcggtaggc atgcctcttc tggggcagag gcggaggcga 23280 cgggctctcg cggttcggcg ggcggctggc agagcccctt ccgcgttcgg gggtgcgctc 23340 ctggcggcgc tgctctgact gacttcctcc gcggccggcc attgtgttct cctagggagc 23400 aacaacaagc atggagactc agccatcgtc gccaacatcg ccatctgccc ccgcctccac 23460 cgccgacgag aaccagcagc agaatgaaag cttaaccgcc ccgccgccca gccccacctc 23520 cgacgccgcg gccccagaca tgcaagagat ggaggaatcc atcgagattg acctgggcta 23580 cgtgacgccc gcggagcacg aggaggagct ggcagcgcgc ttttcagccc cggaagagaa 23640 ccaccaagag cagccagagc aggaagcaga gaacgagcag aaccaggctg ggcacgagca 23700 tggcgactac ctgagcgggg cagaggacgt gctcatcaag catctggccc gccaatgcat 23760 catcgtcaag gacgcgctgc tcgaccgcgc cgaggtgccc ctcagcgtgg cggagctcag 23820 ccgcgcctac gagcgcaacc tcttctcgcc gcgcgtgccc cccaagcgcc agcccaacgg 23880 cacctgtgag cccaacccgc gcctcaactt ctacccggtc ttcgcggtgc ccgaggccct 23940 ggccacctac cacctctttt tcaagaacca aagaatcccc gtctcctgcc gcgccaaccg 24000 cacccgcgcc gacgcccttt tcaacctggg ccccggcgcc cgcctacctg atatcgcctc 24060 cttggaagag gttcccaaga tcttcgaggg tctgggcagc gacgagactc gggccgcgaa 24120 cgctctgcaa ggagaaggag gagagcatga gcaccacagc gccctggtcg agttggaagg 24180 cgacaacgcg cggctggcgg tgctcaaacg cacggtcgag ctgacccatt tcgcctaccc 24240 ggctctgaac ctgcccccca aagtcatgag cgccgtcatg gaccaggtgc tcatcaagcg 24300 cgcgtcgccc atctccgagg acgagggcat gcaagacccc gagagcaccg aggatggcaa 24360 gcccgtggtc agcgacgagc agctggcccg gtggctgggt cctaatgcta gtccccagag 24420 tttggaagag cggcgcaagc tcatgatggc cgtggtcctg gtgaccgtgg agctggagtg 24480 cctgcgccgc ttcttcgccg acgcggagac cctgcgcaag gtcgaggaga acctgcacta 24540 cctcttcagg cacgggttcg tgcgccaggc ctgcaagatc tccaacgtgg agctgaccaa 24600 cctggtctcc tacatgggca tcttgcacga gaaccgtctg gggcagaacg tgctgcacac 24660 caccctgcgc ggggaggccc gccgcgacta catccgcgac tgcgtctacc tctacctctg 24720 ccacacctgg cagacgggca tgggcgtgtg gcagcagtgc ctggaggagc agaacctgaa 24780 agagctctgc aagctcctgc agaagaacct caagggtctg tggaccgggt tcgacgagcg 24840 gaccaccgcc tcggatctgg ccgacctcat cttccccgag cgcctcaggc tgacgctgcg 24900 caacggcctg cccgacttta tgagccaaag catgttgcaa aactttcgct ctttcatcct 24960 cgaacgctcc ggaatcctgc ccgccacctg ctccgcgctg ccctcggact tcgtgccgct 25020 gaccttccgc gagtgccccc cgccgctgtg gagccactgc tacctgctgc gcctggccaa 25080 ctacctggcc taccactcgg acgtgatcga ggacgtcagc ggcgagggcc tgctcgagtg 25140 ccactgccgc tgcaacctct gcacgccgca ccgctccctg gcctgcaacc cccagctgct 25200 gagcgagacc cagatcatcg gcaccttcga gttgcaaggg cccagcgatg agggttccgc 25260 cgccaagggg ggtctgaaac tcaccccggg gctgtggacc tcggcctact tgcgcaagtt 25320 cgtgcccgag gactaccatc ccttcgagat caggttctac gaggaccaat cccagccgcc 25380 caaggccgag ctgtcggcct gcgtcatcac ccagggggcg atcctggccc aattgcaagc 25440 catccagaaa tcccgccaag aattcttgct gaaaaagggc cgcggggtct acctcgaccc 25500 ccagaccggt gaggagctca accccggctt cccccagg atg ccc cga gga aac aag 25556 Met Pro Arg Gly Asn Lys 1 5 aag ctg aaa gtg gag ctg ccg ccc gtg gag gat ttg gag gaa gac tgg 25604 Lys Leu Lys Val Glu Leu Pro Pro Val Glu Asp Leu Glu Glu Asp Trp 10 15 20 gag aac agc agt cag gca gag gag gag gag atg gag gaa gac tgg gac 25652 Glu Asn Ser Ser Gln Ala Glu Glu Glu Glu Met Glu Glu Asp Trp Asp 25 30 35 agc act cag gca gag gag gac agc ctg caa gac agt ctg gag gaa gac 25700 Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser Leu Glu Glu Asp 40 45 50 gag gag gag gca gag gtg gaa gaa gca gcc gcc gcc aga ccg tcg tcc 25748 Glu Glu Glu Ala Glu Val Glu Glu Ala Ala Ala Ala Arg Pro Ser Ser 55 60 65 70 tcg gcg ggg gag aaa gca agc agc acg gat acc atc tcc gct ccg ggt 25796 Ser Ala Gly Glu Lys Ala Ser Ser Thr Asp Thr Ile Ser Ala Pro Gly 75 80 85 cgg ggt ccc gct cgg ccc cac agt aga tgg gac gag acc ggg cga ttc 25844 Arg Gly Pro Ala Arg Pro His Ser Arg Trp Asp Glu Thr Gly Arg Phe 90 95 100 ccg aac ccc acc acc cag acc ggt aag aag gag cgg cag gga tac aag 25892 Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys Glu Arg Gln Gly Tyr Lys 105 110 115 tcc tgg cgg ggg cac aaa aac gcc atc gtc tcc tgc ttg cag gcc tgc 25940 Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser Cys Leu Gln Ala Cys 120 125 130 ggg ggc aac atc tcc ttc acc cgg cgc tac ctg ctc ttc cac cgc ggg 25988 Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu Leu Phe His Arg Gly 135 140 145 150 gtg aac ttc ccc cgc aac atc ttg cat tac tac cgt cac ctc cac agc 26036 Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr Arg His Leu His Ser 155 160 165 ccc tac tac ttc caa gaa gag gca gca gaa aaa gac cag aaa acc agc 26084 Pro Tyr Tyr Phe Gln Glu Glu Ala Ala Glu Lys Asp Gln Lys Thr Ser 170 175 180 tagaaaatcc acagcggcgg cagcaggtgg actgaggatc gcggcgaacg agccggcgca 26144 gacccgggag ctgaggaacc ggatctttcc caccctctat gccatcttcc agcagagtcg 26204 ggggcaggag caggaactga aagtcaagaa ccgttctctg cgctcgctca cccgcagttg 26264 tctgtatcac aagagcgaag accaacttca gcgcactctc gaggacgccg aggctctctt 26324 caacaagtac tgcgcgctca ctcttaaaga gtagcccgcg cccgcccaca cacggaaaaa 26384 ggcgggaatt acgtcaccac ctgcgccctt cgcccgacca tcatgagcaa agagattccc 26444 acgccttaca tgtggagcta ccagccccag atgggcctgg ccgccggcgc cgcccaggac 26504 tactccaccc gcatgaactg gctcagtgcc gggcccgcga tgatctcacg ggtgaatgac 26564 atccgcgccc gccgaaacca gatactccta gaacagtcag cgatcgccgc cacgccccgc 26624 catcacctta atccgcgtaa ttggcccgcc gccctggtgt accaggaaat tccccagccc 26684 acgaccgtac tacttccgcg agacgcccag gccgaagtcc agctgactaa ctcaggtgtc 26744 cagctggccg gcggcgccgc cctgtgtcgt caccgccccg ctcagggtat aaagcggctg 26804 gtgatccgag gcagaggcac acagctcaac gacgaggtgg tgagctcttc gctgggtctg 26864 cgacctgacg gagtcttcca actcgccgga tcggggagat cttccttcac gcctcgtcag 26924 gccgtcctga ctttggagag ttcgtcctcg cagccccgct cgggcggcat cggcactctc 26984 cagttcgtgg aggagttcac tccctcggtc tacttcaacc ccttctccgg ctcccccggc 27044 cactacccgg acgagttcat cccgaacttc gacgccatca gcgagtcggt ggacggctac 27104 gattgaatgt cccatggtgg cgcagctgac ctagctcggc ttcgacacct ggaccactgc 27164 cgccgcttcc gctgcttcgc tcgggatctc gccgagtttg cctactttga gctgcccgag 27224 gagcaccctc agggcccagc ccacggagtg cggatcatcg tcgaaggggg cctcgactcc 27284 cacctgcttc ggatcttcag ccagcgaccg atcctggtcg agcgcgaaca aggacagacc 27344 cgtctgaccc tgtactgcat ctgcaaccac cccggcctgc atg aaa gtc ttt gtt 27399 Met Lys Val Phe Val 185 gtc tgc tgt gta ctg agt ata ata aaa gct gag atc agc gac tac tcc 27447 Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu Ile Ser Asp Tyr Ser 190 195 200 gga ctc gat tgt ggt gtt cct gct atc aac cgg tcc ctg ttc ttc acc 27495 Gly Leu Asp Cys Gly Val Pro Ala Ile Asn Arg Ser Leu Phe Phe Thr 205 210 215 ggg aac gaa acc gag ctc cag ctc cag tgt aag ccc cac aag aag tac 27543 Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys Pro His Lys Lys Tyr 220 225 230 235 ctc acc tgg ctg ttc cag ggc tcc ccc atc gcc gtt gtc aac cac tgc 27591 Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala Val Val Asn His Cys 240 245 250 gac aac gac gga gtc ctg ctg agc ggc cct gcc aac ctt act ttt tcc 27639 Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala Asn Leu Thr Phe Ser 255 260 265 acc cgc aga agc aag ctc cag ctc ttc caa ccc ttc ctc ccc ggg acc 27687 Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro Phe Leu Pro Gly Thr 270 275 280 tat cag tgc gtc tcg gga ccc tgc cat cac acc ttc cac ctg atc ccg 27735 Tyr Gln Cys Val Ser Gly Pro Cys His His Thr Phe His Leu Ile Pro 285 290 295 aat acc aca gcg ccg ctc ccc gct act aac aac caa act aac ctc cac 27783 Asn Thr Thr Ala Pro Leu Pro Ala Thr Asn Asn Gln Thr Asn Leu His 300 305 310 315 caa cgc cac cgt cgc gac ctt tcc tct gaa tct aat acc act acc gga 27831 Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser Asn Thr Thr Thr Gly 320 325 330 ggt gag ctc cga ggt cga cca acc tct ggg att tac tac ggc ccc tgg 27879 Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile Tyr Tyr Gly Pro Trp 335 340 345 gag gtg gtg ggg tta ata gcg cta ggc cta gtt gtg ggt ggg ctt ttg 27927 Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val Val Gly Gly Leu Leu 350 355 360 gct ctc tgc tac cta tac ctc cct tgc tgt tcg tac tta gtg gtg ctg 27975 Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser Tyr Leu Val Val Leu 365 370 375 tgt tgc tgg ttt aag aaa tgg ggc aga tca ccc tagtgagctg cggtgtgctg 28028 Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 380 385 390 gtggcggtgc tttcgattgt gggactgggc ggcgcggctg tagtgaagga ggagaaggcc 28088 gatccctgct tgcatttcaa tcccgacaaa tgccagctga gttttcagcc cgatggcaat 28148 cggtgcgcgg tgctgatcaa gtgcggatgg gaatgcgaga acgtgagaat cgagtacaat 28208 aacaagactc ggaacaatac tctcgcgtcc gtgtggcagc ccggggaccc cgagtggtac 28268 accgtctctg tccccggtgc tgacggctcc ccgcgcaccg tgaataatac tttcattttt 28328 gcgcacatgt gcaacacggt catgtggatg agcaagcagt acgatatgtg gccccccacg 28388 aaggagaaca tcgtggtctt ctccatcgct tacagcctgt gcacggcgct aatcaccgct 28448 atcgtgtgcc tgagcattca catgctcatc gctattcgcc ccagaaataa tgccgagaaa 28508 gagaaacagc cataacacgt tttttcacac accttgtttt tacagacaat gcgtctgtta 28568 aattttttaa acattgtgct cagtattgct tatgcctctg gttatgcaaa catacagaaa 28628 accctttatg taggatctga tggtacacta gagggtaccc aatcacaagc caaggttgca 28688 tggtattttt atagaaccaa cactgatcca gttaaacttt gtaagggtga attgccgcgt 28748 acacataaaa ctccacttac atttagttgc agcaataata atcttacact tttttcaatt 28808 acaaaacaat atactggtac ttattacagt acaaactttc atacaggaca agataaatat 28868 tatactgtta aggtagaaaa tcctaccact cctagaacta ccaccaccac caccactact 28928 gcaaagccca ctgtgaaaac tacaactagg accaccacaa ctacagaaac caccaccagc 28988 acaacacttg ctgcaactac acacacacac actaagctaa ccttacagac cactaatgat 29048 ttgatcgccc tgctgcaaaa gggggataac agcaccactt ccaatgagga gatacccaaa 29108 tccatgattg gcattattgt tgctgtagtg gtgtgcatgt tgatcatcgc cttgtgcatg 29168 gtgtactatg ccttctgcta cagaaagcac agactgaacg acaagctgga acacttacta 29228 agtgttgaat tttaattttt tagaaccatg aagatcctag gcctttttag tttttctatc 29288 attacctctg ctctttgtga atcagtggat agagatgtta ctattaccac tggttctaat 29348 tatacactga aagggccacc ctcaggtatg ctttcgtggt attgctattt tggaactgac 29408 actgatcaaa ctgaattatg caattttcaa aaaggcaaaa cctcaaactc taaaatctct 29468 aattatcaat gcaatggcac tgatctgata ctactcaatg tcacgaaagc atatggtggc 29528 agttattatt gccctggaca aaacactgaa gaaatgattt tttacaaagt ggaagtggtt 29588 gatcccacta caccacccac caccacaact attcatacca cacacacaga acaaacacca 29648 gaggcaacag aagcagagtt ggccttccag gttcacggag attcctttgc tgtcaatacc 29708 cctacacccg atcagcggtg tccggggccg ctagtcagcg gcattgtcgg tgtgctttcg 29768 ggattagcag tcataatcat ctgcatgttc atttttgctt gctgctatag aaggctttac 29828 cgacaaaaat cagacccact gctgaacctc tatgtttaat tttttccaga gccatgaagg 29888 cagttagcgc tctagttttt tgttctttga ttgacattgt ttttaatagt aaaattacca 29948 aagttagctt tattaaacat gttaatgtaa ctgaaggaga taacatcaca ctagcaggtg 30008 tagaaggtgc tcaaaacacc acctggacaa aataccatct aggatggaga gatatttgca 30068 cctggaatgt aacttattat tgcataggaa ttaatcttac cattgttaac gctaaccaat 30128 ctcagaatgg gttaattaaa ggacagagtg ttagtgtgac cagtgatggg tactataccc 30188 agcatagttt taactacaac attactgtca taccactgcc tacgcctagc ccacctagca 30248 ctaccacaca gacaaccaca tacagtacat caaatcagcc taccaccact acagcagcag 30308 aggttgccag ctcgtctggg gtccgagtgg catttttgat gttggcccca tctagcagtc 30368 ccactgctag taccaatgag cagactactg aatttttgtc cactgtcgag agccacacca 30428 cagctacctc cagtgccttc tctagcaccg ccaatctctc ctcgctttcc tctacaccaa 30488 tcagccccgc tactactcct agccccgctc ctcttcccac tcccctgaag caaacagacg 30548 gcggcatgca atggcagatc accctgctca ttgtgatcgg gttggtcatc ctggccgtgt 30608 tgctctacta catcttctgc cgccgcattc ccaacgcgca ccgcaagccg gcctacaagc 30668 ccatcgttat cgggcagccg gagccgcttc aggtggaagg gggtctaagg aatcttctct 30728 tctcttttac agtatggtga ttgaactatg attcctagac aattcttgat cactattctt 30788 atctgcctcc tccaagtctg tgccaccctc gctctggtgg ccaacgccag tccagactgt 30848 attgggccct tcgcctccta cgtgctcttt gccttcatca cctgcatctg ctgctgtagc 30908 atagtctgcc tgcttatcac cttcttccag ttcattgact ggatctttgt gcgcatcgcc 30968 tacctgcgcc accaccccca gtaccgcgac cagcgagtgg cgcagctgct caggctcctc 31028 tgataagcat gcgggctctg ctacttctcg cacttctgct gttagtgctc ccccgtcccg 31088 ttgacccccg gccccccact cagtcccccg aggaggtccg caaatgcaaa ttccaagaac 31148 cctggaaatt cctcaaatgc taccgccaaa aatcagacat gcatcccagc tggatcatga 31208 tcattgggat cgtgaacatt ctggcctgca ccctcatctc ctttgtgatt tacccctgct 31268 ttgactttgg ttggaactcg ccagaggcgc tctatctccc gcctgaacct gacacaccac 31328 cacagcaacc tcaggcacac gcactaccac caccaccaca gcctaggcca caatacatgc 31388 ccatattaga ctatgaggcc gagccacagc gacccatgct ccccgctatt agttacttca 31448 atctaaccgg cggag atg act gac cca ctg gcc aac aac aac gtc aac gac 31499 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp 395 400 ctt ctc ctg gac atg gac ggc cgc gcc tcg gag cag cga ctc gcc caa 31547 Leu Leu Leu Asp Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln 405 410 415 ctt cgc att cgc cag cag cag gag aga gcc gtc aag gag ctg cag gac 31595 Leu Arg Ile Arg Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp 420 425 430 ggc ata gcc atc cac cag tgc aag aaa ggc atc ttc tgc ctg gtg aaa 31643 Gly Ile Ala Ile His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys 435 440 445 450 cag gcc aag atc tcc tac gag gtc acc cag acc gac cat cgc ctc tcc 31691 Gln Ala Lys Ile Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser 455 460 465 tac gag ctc ctg cag cag cgc cag aag ttc acc tgc ctg gtc gga gtc 31739 Tyr Glu Leu Leu Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val 470 475 480 aac ccc atc gtc atc acc cag cag tcg ggc gat acc aag ggg tgc atc 31787 Asn Pro Ile Val Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile 485 490 495 cac tgc tcc tgc gac tcc ccc gac tgc gtc cac act ctg atc aag acc 31835 His Cys Ser Cys Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr 500 505 510 ctc tgc ggc ctc cgc gac ctc ctc ccc atg aac taatcacccc cttatccagt 31888 Leu Cys Gly Leu Arg Asp Leu Leu Pro Met Asn 515 520 525 gaaataaaga tcatattgat gattaaataa aa 31920 <210> 172 <211> 182 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 172 Met Pro Arg Gly Asn Lys Lys Leu Lys Val Glu Leu Pro Pro Val Glu 1 5 10 15 Asp Leu Glu Glu Asp Trp Glu Asn Ser Ser Gln Ala Glu Glu Glu Glu 20 25 30 Met Glu Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln 35 40 45 Asp Ser Leu Glu Glu Asp Glu Glu Glu Ala Glu Val Glu Glu Ala Ala 50 55 60 Ala Ala Arg Pro Ser Ser Ser Ala Gly Glu Lys Ala Ser Ser Thr Asp 65 70 75 80 Thr Ile Ser Ala Pro Gly Arg Gly Pro Ala Arg Pro His Ser Arg Trp 85 90 95 Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys 100 105 110 Glu Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val 115 120 125 Ser Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr 130 135 140 Leu Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr 145 150 155 160 Tyr Arg His Leu His Ser Pro Tyr Tyr Phe Gln Glu Glu Ala Ala Glu 165 170 175 Lys Asp Gln Lys Thr Ser 180 <210> 173 <211> 208 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 173 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Asp Cys Gly Val Pro Ala Ile Asn Arg 20 25 30 Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys 35 40 45 Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala 50 55 60 Val Val Asn His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala 65 70 75 80 Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro 85 90 95 Phe Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro Cys His His Thr 100 105 110 Phe His Leu Ile Pro Asn Thr Thr Ala Pro Leu Pro Ala Thr Asn Asn 115 120 125 Gln Thr Asn Leu His Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser 130 135 140 Asn Thr Thr Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile 145 150 155 160 Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val 165 170 175 Val Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser 180 185 190 Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 195 200 205 <210> 174 <211> 135 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 174 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu Leu Leu Asp 1 5 10 15 Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg 20 25 30 Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Gly Ile Ala Ile 35 40 45 His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile 50 55 60 Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser Tyr Glu Leu Leu 65 70 75 80 Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val 85 90 95 Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys 100 105 110 Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu 115 120 125 Arg Asp Leu Leu Pro Met Asn 130 135 <210> 175 <211> 38677 <212> DNA <213> Artificial Sequence <220> <223> Simian adenovirus A1337 clone <220> <221> misc_feature <222> (5)..(12) <223> Pme\I <220> <221> repeat_region <222> (22)..(144) <223> ITR <220> <221> misc_feature <222> (471)..(496) <223> I-Ceu\recognition site <220> <221> misc_feature <222> (484)..(485) <223> cleavage point for bottom strand <220> <221> misc_feature <222> (488)..(489) <223> cleavage point for top strand <220> <221> enhancer <222> (838)..(1098) <223> Enhancer <220> <221> misc_feature <222> (1099)..(1326) <223> CMV promoter <220> <221> TATA_signal <222> (1300)..(1303) <223> TATA <220> <221> CDS <222> (1422)..(2513) <223> Gag\short <220> <221> polyA_signal <222> (2666)..(2868) <223> BGH-PolyA <220> <221> misc_feature <222> (2941)..(2979) <223> PI-Scel recognition site <220> <221> misc_feature <222> (2951)..(2952) <223> cleavage point on bottom strand <220> <221> misc_feature <222> (2955)..(2956) <223> cleavage point on top strand <220> <221> misc_feature <222> (3947)..(5568) <223> IVa2 complement (3947..5277,5557..5568) <220> <221> misc_feature <222> (5557)..(13808) <223> pol complement (5557..8622,13800..13808) <220> <221> misc_feature <222> (8430)..(13808) <223> pTP complement (8430..10358,13800..13808) <220> <221> CDS <222> (10795)..(11976) <223> 52K <220> <221> CDS <222> (12003)..(13769) <223> pIIIa <220> <221> CDS <222> (13853)..(15448) <223> penton <220> <221> CDS <222> (15455)..(16033) <223> pVII <220> <221> CDS <222> (16078)..(17103) <223> V <220> <221> CDS <222> (17130)..(17360) <223> pX <220> <221> CDS <222> (17395)..(18171) <223> pVI <220> <221> CDS <222> (18277)..(21069) <223> hexon <220> <221> CDS <222> (21085)..(21714) <223> protease <220> <221> misc_feature <222> (21794)..(23329) <223> DBP complement (21794..23329) <220> <221> CDS <222> (23358)..(25760) <223> 100K <220> <221> CDS <222> (26382)..(27062) <223> pVIII <220> <221> CDS <222> (27066)..(27383) <223> E3\12.5K <220> <221> CDS <222> (27960)..(28487) <223> E3\gp19K <220> <221> CDS <222> (28526)..(29266) <223> E3\CR1-beta <220> <221> CDS <222> (29928)..(30800) <223> E3\CR1-delta <220> <221> CDS <222> (31087)..(31533) <223> E3\RID-beta <220> <221> CDS <222> (32042)..(33511) <223> fiber <220> <221> misc_feature <222> (33607)..(34934) <223> E4\orf6/7 complement (33607..33857,34581..34934) <220> <221> misc_feature <222> (33858)..(34754) <223> E4\orf6 complement (33858..34754) <220> <221> misc_feature <222> (34660)..(35025) <223> E4\orf4 complement (34660..35025) <220> <221> misc_feature <222> (35037)..(35387) <223> E4\orf3 complement (35037..35387) <220> <221> misc_feature <222> (35387)..(35773) <223> E4\orf2 complement (35387..35773) <220> <221> misc_feature <222> (35826)..(36197) <223> E4\orf1 complement (35826..36197) <220> <221> repeat_region <222> (36475)..(36697) <223> ITR <220> <221> misc_feature <222> (36607)..(36614) <223> Pme\I <220> <221> misc_feature <222> (36843)..(36849) <223> pMB1\ORI complement (36843..36849) <220> <221> misc_feature <222> (36852)..(37440) <223> pMB1\ori <220> <221> rep_origin <222> (36853)..(36853) <223> ORI <220> <221> misc_feature <222> (37611)..(38474) <223> AP(R) complement (37611..38474) <400> 175 aattgtttaa actaccatca tcaataatat acctcaaact ttttgtgcgc gttaatatgc 60 aaatgaggcg tttgaatttg ggaagggagg aaggtgattg gccgagagaa gggcgaccgt 120 taggggcggg gcgagtgacg ttttgatgac gtggccgcga ggaggagcca gtttgcaagt 180 tctcgtggga aaagtgacgt caaacgaggt gtggtttgaa cacggaaata ctcaattttc 240 ccgcgctctc tgacaggaaa tgaggtgttt ttgggcggat gcaagttaaa acgggccatt 300 ttcgcgcgaa aactgaatga ggaagtgaaa atctgagtaa tttcgcgttt atggcaggga 360 ggagtatttg ccgagggccg agtagacttt gaccgattac gtgggggttt cgattaccgt 420 gtttttcacc taaatttccg cgtacggtgt caaagtccgg tgtttttacg taactataac 480 ggtcctaagg tagcgaaagc tcagatctgg atctcccgat cccctatggc gactctcagt 540 acaatctgct ctgatgccgc atagttaagc cagtatctgc tccctgcttg tgtgttggag 600 gtcgctgagt agtgcgcgag caaaatttaa gctacaacaa ggcaaggctt gaccgacaat 660 tgcatgaaga atctgcttag ggttaggcgt tttgcgctgc ttcgcgatgt acgggccaga 720 tatacgcgtt gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta 780 gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc 840 tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg 900 ccaataggga ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg 960 gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa 1020 tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac 1080 atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg 1140 cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg 1200 agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca 1260 ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta 1320 gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac 1380 cgggaccgat ccagcctccg cgggcgcgcg tcgacagaga g atg ggt gcg aga gcg 1436 Met Gly Ala Arg Ala 1 5 tca gta tta agc ggg gga gaa tta gat cga tgg gaa aaa att cgg tta 1484 Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp Glu Lys Ile Arg Leu 10 15 20 agg cca ggg gga aag aag aag tac aag cta aag cac atc gta tgg gca 1532 Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys His Ile Val Trp Ala 25 30 35 agc agg gag cta gaa cga ttc gca gtt aat cct ggc ctg tta gaa aca 1580 Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro Gly Leu Leu Glu Thr 40 45 50 tca gaa ggc tgt aga caa ata ctg gga cag cta caa cca tcc ctt cag 1628 Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu Gln Pro Ser Leu Gln 55 60 65 aca gga tca gag gag ctt cga tca cta tac aac aca gta gca acc ctc 1676 Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn Thr Val Ala Thr Leu 70 75 80 85 tat tgt gtg cac cag cgg atc gag atc aag gac acc aag gaa gct tta 1724 Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp Thr Lys Glu Ala Leu 90 95 100 gac aag ata gag gaa gag caa aac aag tcc aag aag aag gcc cag cag 1772 Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys Lys Lys Ala Gln Gln 105 110 115 gca gca gct gac aca gga cac agc aat cag gtc agc caa aat tac cct 1820 Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val Ser Gln Asn Tyr Pro 120 125 130 ata gtg cag aac atc cag ggg caa atg gta cat cag gcc ata tca cct 1868 Ile Val Gln Asn Ile Gln Gly Gln Met Val His Gln Ala Ile Ser Pro 135 140 145 aga act tta aat gca tgg gta aaa gta gta gaa gag aag gct ttc agc 1916 Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu Glu Lys Ala Phe Ser 150 155 160 165 cca gaa gtg ata ccc atg ttt tca gca tta tca gaa gga gcc acc cca 1964 Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser Glu Gly Ala Thr Pro 170 175 180 cag gac ctg aac acg atg ttg aac acc gtg ggg gga cat caa gca gcc 2012 Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln Ala Ala 185 190 195 atg caa atg tta aaa gag acc atc aat gag gaa gct gca gat tgg gat 2060 Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu Ala Ala Asp Trp Asp 200 205 210 aga gtg cat cca gtg cat gca ggg cct att gca cca ggc cag atg aga 2108 Arg Val His Pro Val His Ala Gly Pro Ile Ala Pro Gly Gln Met Arg 215 220 225 gaa cca agg gga agt gac ata gca gga act act agt acc ctt cag gaa 2156 Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Thr Leu Gln Glu 230 235 240 245 caa ata gga tgg atg aca aat aat cca cct atc cca gta gga gag atc 2204 Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile Pro Val Gly Glu Ile 250 255 260 tac aag agg tgg ata atc ctg gga ttg aac aag atc gtg agg atg tat 2252 Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg Met Tyr 265 270 275 agc cct acc agc att ctg gac ata aga caa gga cca aag gaa ccc ttt 2300 Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly Pro Lys Glu Pro Phe 280 285 290 aga gac tat gta gac cgg ttc tat aaa act cta aga gct gag caa gct 2348 Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu Arg Ala Glu Gln Ala 295 300 305 tca cag gag gta aaa aat tgg atg aca gaa acc ttg ttg gtc caa aat 2396 Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr Leu Leu Val Gln Asn 310 315 320 325 gcg aac cca gat tgt aag acc atc ctg aag gct ctc ggc cca gcg gct 2444 Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala Leu Gly Pro Ala Ala 330 335 340 aca cta gaa gaa atg atg aca gca tgt cag gga gta gga gga ccc ggc 2492 Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly Pro Gly 345 350 355 cat aag gca aga gtt ttg tag ggatccacta gttctagact cgaggggggg 2543 His Lys Ala Arg Val Leu 360 cccggtacct ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa 2603 agaaaagggg ggactggaag ggctaattca ctcccaaaga agacaagata aaccgctgat 2663 cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt 2723 ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat 2783 cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg 2843 gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg 2903 aggcggaaag aaccagcaga tctgcagatc tgaattcatc tatgtcgggt gcggagaaag 2963 aggtaatgaa atggcacata tgctggccac cgtgcatgtg gcttcccatg cccgcaagcc 3023 ctggcccgag ttcgagcaca atgtcatgac caggtgcaat atgcatctgg ggtctcgccg 3083 aggcatgttc atgccctacc agtgcaacct gaattatgtg aaggtgctgc tggagcccga 3143 tgccatgtcc agagtgagcc tgacgggggt gtttgacatg aatgtggagg tgtggaagat 3203 tctgagatat gatgaatcca agaccaggtg ccgagcctgc gagtgcggag ggaagcatgc 3263 caggttccag cccgtgtgtg tggatgtgac ggaggacctg cgacccgatc atttggtgtt 3323 gtcctgcacc gggacggagt tcggttccag cggggaagaa tctgactaga gtgagtagtg 3383 ttctggggcg ggggaggacc tgcatgaggg ccagaatgat tgaaatctgt gcttttctgt 3443 gtgttgcagc agcatgagcg gaagcggctc ctttgaggga ggggtattca gcccttatct 3503 gacggggcgt ctcccctcct gggcgggagt gcgtcagaat gtgatgggat ccacggtgga 3563 cggccggccc gtgcagcccg cgaactcttc aaccctgacc tatgcaaccc tgagctcttc 3623 gtcggtggac gcagctgccg ccgcagctgc tgcatctgcc gccagcgccg tgcgcggaat 3683 ggccatgggc gccggctact acggcactct ggtggccaac tcgagttcca ccaataatcc 3743 cgccagcctg aacgaggaga agctgctgct gctgatggcc cagctcgagg ccttgaccca 3803 gcgcctgggc gagctgaccc agcaggtggc tcagctgcag gagcagacgc gggccgcggt 3863 tgccacggtg aaatccaaat aaaaaatgaa tcaataaata aacggagacg gttgttgatt 3923 ttaacacaga gtctgaatct ttatttgatt tttcgcgcgc ggtaggccct ggaccaccgg 3983 tctcgatcat tgagcactcg gtggatcttt tccaggaccc ggtagaggtg ggcttggatg 4043 ttgaggtaca tgggcatgag cccgtcccgg gggtggaggt agctccattg cagggcctcg 4103 tgctcggggg tggtgttgta aatcacccag tcatagcagg ggcgcagggc atggtgttgc 4163 acaatatctt tgaggaggag actgatggcc acgggcagcc ctttggtgta ggtgtttaca 4223 aatctgttga gctgggaggg atgcatgcgg ggggagatga ggtgcatctt ggcctggatc 4283 ttgagattgg cgatgttacc gcccagatcc cgcctggggt tcatgttgtg caggaccacc 4343 agcacggtgt atccggtgca cttggggaat ttatcatgca acttggaagg gaaggcgtga 4403 aagaatttgg cgacgccctt gtgcccgccc aggttttcca tgcactcatc catgatgatg 4463 gcgatggggc cgtgggcggc ggcctgggca aaaacgtttc gggggtcgga cacatcatag 4523 ttgtggtcct gggtgagatc atcataggcc attttaatga atttggggcg gagggtgccg 4583 gactggggga caaaggtacc ctcgatcccg ggggcgtagt tcccctcaca gatctgcatc 4643 tcccaggctt tgagctcgga gggggggatc atgtccacct gcggggcgat aaagaacacg 4703 gtttccgggg cgggagagat gagctgggcc gaaagcaagt tccggagcag ctgggacttg 4763 ccgcagccgg tggggccgta gatgaccccg atgaccggtt gcaggtggta gttgagggag 4823 agacagctgc cgtcctcccg gaggaggggg gccacctcgt tcatcatctc gcgcacgtgc 4883 atgttctcgc gcaccagttc cgccaggagg cgctctcccc ccagggatag gagctcctgg 4943 agcgaggcga agtttttcag cggcttgagt ccgtcggcca tgggcatttt ggagagggtc 5003 tgttgcaaga gttccaagcg gtcccagagc tcggtgatgt gctctacggc atctcgatcc 5063 agcagacctc ctcgtttcgc gggttggggc ggctgcggga gtagggcacc agacgatggg 5123 cgtccagcgc agccagggtc cggtccttcc agggtcgcag cgtccgcgtc agggtggtct 5183 ccgtcacggt gaaggggtgc gcgccgggct gggcgcttgc gagggtgcgc ttcaggctca 5243 tccggctggt cgaaaaccgc tcccgatcgg cgccctgcgc gtcggccagg tagcaattga 5303 ccatgagttc gtaattgagc gcctcggccg cgtgaccttt ggcgcggagc ttacctttgg 5363 aagtctgccc gcaggtggga cagaggaggg acttgagggc gtagagcttg ggggcgagga 5423 agacggactc gggggcgtag gcgtccgcgc cgcagtgggc gcagacggtc tcgcactcca 5483 cgagccaggt gaggtcgggc tggtcggggt caaaaaccag tttcccgccg ttctttttga 5543 tgcgtttctt acctttggtc tccatgagct cgtgtccccg ctgggtgaca aagaggctgt 5603 ccgtgtcccc gtagaccgac tttatgggcc ggtcctcgag cggtgtgccg cggtcctcct 5663 cgtagaggaa ccccgcccac tccgagacga aagcccgggt ccaggccagc acgaaggagg 5723 ccacgtggga cgggtagcgg tcgttgtcca ccagcgggtc caccttctcc agggtatgca 5783 aacacatgtc cccctcgtcc acatccagga aggtgattgg cttgtaagtg taggccacgt 5843 gaccgggggt cccagccggg ggggtataaa agggggcggg cccctgctcg tcctcactgt 5903 cttccggatc gctgtccagg agcgccagct gttggggtag gtattccctc tcgaaggcgg 5963 gcatgacctc ggcactcagg ttgtcagttt ctagaaacga ggaggatttg atattgacgg 6023 tgccggcgga gatgcctttc aagagcccct cgtccatctg gtcagaaaag acgatctttt 6083 tgttgtcgag tttggtggcg aaggagccgt agagggcatt ggagaggagc ttggcgatag 6143 agcgcatggt ctggtttttt tccttgtcgg cgcgctcctt ggccgcgatg ttgagctgca 6203 cgtactcgcg cgccacgcac ttccattcgg ggaagacggt ggtcagctcg tcgggcacga 6263 ttctgacttg ccagccccgg ttatgcaggg tgatgaggtc cacactggtg cccacctcgc 6323 cgcgcagggg ctcgttggtc cagcagagtc gaccgccctt gcgcgagcag aaggggggca 6383 gggggtccag catgacctcg tcgggggggt cggcatcgat ggtgaagatg cctggcagga 6443 gatcggggtc gaagtagctg atggaagtgg ccagatcgtc cagggcagct tgccattcgc 6503 gcacggccag cgcgcgctcg tagggactga ggggcgtgcc ccaaggcatg gggtgtgtga 6563 gcgcggaggc gtacatgccg cagatgtcgt agacgtagag gggctcctcg aggatgccga 6623 tgtaggtggg gtaacagcgc cccccgcgga tgctggcgcg cacgtagtca tacagctcat 6683 gcgagggggc gaggagcccc gggcccaggt tggtgcgact gggcttttcg gcgcggtaga 6743 cgatctggcg aaagatggca tgcgagttgg aggagatggt gggcctttgg aagatgttga 6803 agtgggcgtg gggcagaccg accgagtcgc ggatgaagtg ggcgtaggag tcttgcagtt 6863 tggcgacgag ctcggcggtg acgaggacgt ccagagcgca gtagtcgagg gtctcctgga 6923 tgatgtcata cttgagctgg cccttttgtt tccacagctc gcggttgaga aggaactctt 6983 cgcggtcctt ccagtactct tcgaggggga acccgtcctg atctgcacgg taagagccta 7043 gcatgtagaa ctggttgacg gccttgtagg cgcagcagcc cttctccacg gggagggcgt 7103 aggcctgggc ggccttgcgc agggaggtgt gcgtgagggc gaaggtgtcc ctgaccatga 7163 ccttgaggaa ctggtgcttg aaatcgatat cgtcgcagcc cccctgctcc cagagctgga 7223 agtccgtgcg cttcttgtag gcggggttgg gcaaagcgaa agtaacatcg ttgaaaagga 7283 tcttgcccgc gcggggcata aagttgcgag tgatgcggaa aggctggggc acctcggccc 7343 ggttgttgat gacctgggcg gcgagcacga tctcgtcgaa accgttgatg ttgtggccca 7403 cgatgtagag ttccacgaat cgcgggcggc ccttgacgtg gggcagcttc ttgagctcct 7463 cgtaggtgag ctcgtcgggg tcgctgagac cgtgctgctc gagcgcccag tcggcgagat 7523 gggggttggc gcggaggaag gaagtccaga gatccacggc cagggcggtt tgcagacggt 7583 cccggtactg acggaactgc tgcccgacgg ccattttttc gggggtgacg cagtagaagg 7643 tgcgggggtc cccgtgccag cggtcccatt tgagctggag ggcgagatcg agggcgagct 7703 cgacgaggcg gtcgtccccg gagagtttca tgaccagcat gaaggggacg agctgcttgc 7763 cgaaggaccc catccaggtg taggtttcca catcgtaggt gaggaagagc ctttcggtgc 7823 gaggatgcga gccgatgggg aagaactgga tctcctgcca ccaattggag gaatggctgt 7883 tgatgtgatg gaagtagaaa tgccgacggc gcgccgaaca ctcgtgcttg tgtttataca 7943 agcggccaca gtgctcgcaa cgctgcacgg gatgcacgtg ctgcacgagc tgtacctgag 8003 ttcctttgac gaggaatttc agtgggaagt ggagtcgtgg cgcctgcatc tcgtgctgta 8063 ctacgtcgtg gtggtcggcc tggccctctt ctgcctcgat ggtggtcatg ctgacgagcc 8123 cgcgcgggag gcaggtccag acctcggcgc gagcgggtcg gagagcgagg acgagggcgc 8183 gcaggccgga gctgtccagg gtcctgagac gctgcggagt caggtcagtg ggcagcggcg 8243 gcgcgcggtt gacttgcagg agtttttcca gggcgcgcgg gaggtccaga tggtacttga 8303 tctccaccgc gccgttggtg gcgacgtcga tggcttgcag ggtcccgtgc ccctggggtg 8363 tgaccaccgt cccccgtttc ttcttgggcg gctggggcga cgggggcggt gcctcttcca 8423 tggttagaag cggcggcgag gacgcgcgcc gggcggcaga ggcggctcgg ggcccggagg 8483 caggggcggc aggggcacgt cggcgccgcg cgcgggtagg ttctggtact gcgcccggag 8543 aagactggcg tgagcgacga cgcgacggtt gacgtcctgg atctgacgcc tctgggtgaa 8603 ggccacggga cccgtgagtt tgaacctgaa agagagttcg acagaatcaa tctcggtatc 8663 gttgacggcg gcctgccgca ggatctcttg cacgtcgccc gagttgtcct ggtaggcgat 8723 ctcggtcatg aactgctcga tctcctcctc ctgaaggtct ccgcggccgg cgcgctccac 8783 ggtggccgcg aggtcgttgg agatgcggcc catgagctgc gagaaggcgt tcatgcccgc 8843 ctcgttccag acgcggctgt agaccacgac gccctcggga tcgcgggcgc gcatgaccac 8903 ctgggcgagg ttgagctcca cgtggcgcgt gaagaccgcg tagttgcaga ggcgctggta 8963 gaggtagttg agcgtggtgg cgatgtgctc ggtgacgaag aaatacatga tccagcggcg 9023 gagcggcatc tcgctgacgt cgcccagcgc ctccaagcgt tccatggcct cgtaaaagtc 9083 cacggcgaag ttgaaaaact gggagttgcg cgccgagacg gtcaactcct cctccagaag 9143 acggatgagc tcggcgatgg tggcgcgcac ctcgcgctcg aaggcccccg ggagttcctc 9203 ctcttccatc tcctcttctt cctcctccac taacatctct tctacttcct cctcaggcgg 9263 tggtggcggg ggagggggcc tgcgtcgccg gcggcgcacg ggcagacggt cgatgaagcg 9323 ctcgatggtc tcgccgcgcc ggcgtcgcat ggtctcggtg acggcgcgcc cgtcctcgcg 9383 gggccgcagc gtgaagacgc cgccgcgcat ctccaggtgg ccgggggggt ccccgttggg 9443 cagggagagg gcgctgacga tgcatcttat caattgcccc gtagggactc cgcgcaagga 9503 cctgagcgtc tcgagatcca cgggatctga aaaccgttga acgaaggctt cgagccagtc 9563 gcagtcgcaa ggtaggctga gcacggtttc ttctggcggg tcatgttggg gagcggggcg 9623 ggcgatgctg ctggtgatga agttgaaata ggcggttctg agacggcgga tggtggcgag 9683 gagcaccagg tctttgggcc cggcttgctg gatgcgcaga cggtcggcca tgccccaggc 9743 gtggtcctga cacctggcca ggtccttgta gtagtcctgc atgagccgct ccacgggcac 9803 ctcctcctcg cccgcgcggc cgtgcatgcg cgtgagcccg aagccgcgct ggggctggac 9863 gagcgccagg tcggcgacga cgcgctcggc gaggatggcc tgctggatct gggtgagggt 9923 ggtctggaag tcgtcaaagt cgacgaagcg gtggtaggct ccggtgttga tggtgtagga 9983 gcagttggcc atgacggacc agttgacggt ctggtggccc ggacgcacga gctcgtggta 10043 cttgaggcgc gagtaggcgc gcgtgtcgaa gatgtagtcg ttgcaggtgc gcaccaggta 10103 ctggtagccg atgaggaagt gcggcggcgg ctggcggtag agcggccatc gctcggtggc 10163 gggggcgccg ggcgcgaggt cctcgagcat ggtgcggtgg tagccgtaga tgtacctgga 10223 catccaggtg atgccggcgg cggtggtgga ggcgcgcggg aactcgcgga cgcggttcca 10283 gatgttgcgc agcggcagga agtagttcat ggtgggcacg gtctggcccg tgaggcgcgc 10343 gcagtcgtgg atgctctata cgggcaaaaa cgaaagcggt cagcggctcg actccgtggc 10403 ctggaggcta agcgaacggg ttgggctgcg cgtgtacccc ggttcgaatc tcgaatcagg 10463 ctggagccgc agctaacgtg gtactggcac tcccgtctcg acccaagcct gcaccaaccc 10523 tccaggatac ggaggcgggt cgttttgcaa ctttttttcg gaggccggaa atgaagacta 10583 gtaagcgcgg aaagcggccg accgcgatgg ctcgctgccg tagtctggag aagaatcgcc 10643 agggttgcgt tgcggtgtgc cccggttcga ggccggccgg attccgcggc taacgagggc 10703 gtggctgccc cgtcgtttcc aagaccccct agccagccga cttctccagt tacggagcga 10763 gcccctcttt tgttttgttt gtttttgcca g atg cat ccc gta ctg cgg cag 10815 Met His Pro Val Leu Arg Gln 365 370 atg cgc ccc cac cac cct cca ccg caa caa cag ccc cct cca cag ccg 10863 Met Arg Pro His His Pro Pro Pro Gln Gln Gln Pro Pro Pro Gln Pro 375 380 385 gcg ctt ctg ccc ccg ccc cag cag cag cag caa ctt cca gcc acg acc 10911 Ala Leu Leu Pro Pro Pro Gln Gln Gln Gln Gln Leu Pro Ala Thr Thr 390 395 400 gcc gcg gcc gcc gtg agc ggg gct gga cag act tct cag tat gac ctg 10959 Ala Ala Ala Ala Val Ser Gly Ala Gly Gln Thr Ser Gln Tyr Asp Leu 405 410 415 gcc ttg gaa gag ggc gag ggg ctg gcg cgc ctg ggg gcg tcg tcg ccg 11007 Ala Leu Glu Glu Gly Glu Gly Leu Ala Arg Leu Gly Ala Ser Ser Pro 420 425 430 gag cgg cac ccg cgc gtg cag atg aaa agg gac gct cgc gag gcc tac 11055 Glu Arg His Pro Arg Val Gln Met Lys Arg Asp Ala Arg Glu Ala Tyr 435 440 445 450 gtg ccc aag cag aac ctg ttc aga gac agg agc ggc gag gag ccc gag 11103 Val Pro Lys Gln Asn Leu Phe Arg Asp Arg Ser Gly Glu Glu Pro Glu 455 460 465 gag atg cgc gcg gcc cgg ttc cac gcg ggg cgg gag ctg cgg cgc ggc 11151 Glu Met Arg Ala Ala Arg Phe His Ala Gly Arg Glu Leu Arg Arg Gly 470 475 480 ctg gac cga aag agg gtg ctg agg gac gag gat ttc gag gcg gac gag 11199 Leu Asp Arg Lys Arg Val Leu Arg Asp Glu Asp Phe Glu Ala Asp Glu 485 490 495 ctg acg ggg atc agc ccc gcg cgc gcg cac gtg gcc gcg gcc aac ctg 11247 Leu Thr Gly Ile Ser Pro Ala Arg Ala His Val Ala Ala Ala Asn Leu 500 505 510 gtc acg gcg tac gag cag acc gtg aag gag gag agc aac ttc caa aaa 11295 Val Thr Ala Tyr Glu Gln Thr Val Lys Glu Glu Ser Asn Phe Gln Lys 515 520 525 530 tcc ttc aac aac cac gtg cgc acc ctg atc gcg cgc gag gag gtg acc 11343 Ser Phe Asn Asn His Val Arg Thr Leu Ile Ala Arg Glu Glu Val Thr 535 540 545 ctg ggc ctg atg cac ctg tgg gac ctg ctg gag gcc atc gtg cag aac 11391 Leu Gly Leu Met His Leu Trp Asp Leu Leu Glu Ala Ile Val Gln Asn 550 555 560 ccc acc agc aag ccg ctg acg gcg cag ctg ttc ctg gtg gtg cag cat 11439 Pro Thr Ser Lys Pro Leu Thr Ala Gln Leu Phe Leu Val Val Gln His 565 570 575 agt cgg gac aac gag gcg ttc agg gag gcg ctg ctg aat atc acc gag 11487 Ser Arg Asp Asn Glu Ala Phe Arg Glu Ala Leu Leu Asn Ile Thr Glu 580 585 590 ccc gag ggc cgc tgg ctc ctg gac ctg gtg aac att ctg cag agc atc 11535 Pro Glu Gly Arg Trp Leu Leu Asp Leu Val Asn Ile Leu Gln Ser Ile 595 600 605 610 gtg gtg cag gag cgc ggg ctg ccg ctg tcc gag aag ctg gcg gcc atc 11583 Val Val Gln Glu Arg Gly Leu Pro Leu Ser Glu Lys Leu Ala Ala Ile 615 620 625 aac ttc tcg gtg ctg agt ctg ggc aag tac tac gct agg aag atc tac 11631 Asn Phe Ser Val Leu Ser Leu Gly Lys Tyr Tyr Ala Arg Lys Ile Tyr 630 635 640 aag acc ccg tac gtg ccc ata gac aag gag gtg aag atc gac ggg ttt 11679 Lys Thr Pro Tyr Val Pro Ile Asp Lys Glu Val Lys Ile Asp Gly Phe 645 650 655 tac atg cgc atg acc ctg aaa gtg ctg acc ctg agc gac gat ctg ggg 11727 Tyr Met Arg Met Thr Leu Lys Val Leu Thr Leu Ser Asp Asp Leu Gly 660 665 670 gtg tac cgc aac gac agg atg cac cgc gcg gtg agc gcc agc agg cgg 11775 Val Tyr Arg Asn Asp Arg Met His Arg Ala Val Ser Ala Ser Arg Arg 675 680 685 690 cgc gag ctg agc gac cag gag ctg atg cat agt ctg cag cgg gcc ctg 11823 Arg Glu Leu Ser Asp Gln Glu Leu Met His Ser Leu Gln Arg Ala Leu 695 700 705 acc ggg gcc ggg acc gag ggg gag agc tac ttt gac atg ggc gcg gac 11871 Thr Gly Ala Gly Thr Glu Gly Glu Ser Tyr Phe Asp Met Gly Ala Asp 710 715 720 ctg cac tgg cag ccc agc cgc cgg gcc ttg gag gcg gca ggc ggt ccc 11919 Leu His Trp Gln Pro Ser Arg Arg Ala Leu Glu Ala Ala Gly Gly Pro 725 730 735 ccc tac ata gaa gag gtg gac gat gag gtg gac gag gag ggc gag tac 11967 Pro Tyr Ile Glu Glu Val Asp Asp Glu Val Asp Glu Glu Gly Glu Tyr 740 745 750 ctg gaa gac tgatggcgcg accgtatttt tgctag atg caa caa cag cca cct 12020 Leu Glu Asp Met Gln Gln Gln Pro Pro 755 760 cct gat ccc gcg atg cgg gcg gcg ctg cag agc cag ccg tcc ggc att 12068 Pro Asp Pro Ala Met Arg Ala Ala Leu Gln Ser Gln Pro Ser Gly Ile 765 770 775 aac tcc tcg gac gat tgg acc cag gcc atg caa cgc atc atg gcg ctg 12116 Asn Ser Ser Asp Asp Trp Thr Gln Ala Met Gln Arg Ile Met Ala Leu 780 785 790 795 acg acc cgc aac ccc gaa gcc ttt aga cag cag ccc cag gcc aac cgg 12164 Thr Thr Arg Asn Pro Glu Ala Phe Arg Gln Gln Pro Gln Ala Asn Arg 800 805 810 ctc tcg gcc atc ctg gag gcc gtg gtg ccc tcg cgc tcc aac ccc acg 12212 Leu Ser Ala Ile Leu Glu Ala Val Val Pro Ser Arg Ser Asn Pro Thr 815 820 825 cac gag aag gtc ctg gcc atc gtg aac gcg ctg gtg gag aac aag gcc 12260 His Glu Lys Val Leu Ala Ile Val Asn Ala Leu Val Glu Asn Lys Ala 830 835 840 atc cgc ggc gac gag gcc ggc ctg gtg tac aac gcg ctg ctg gag cgc 12308 Ile Arg Gly Asp Glu Ala Gly Leu Val Tyr Asn Ala Leu Leu Glu Arg 845 850 855 gtg gcc cgc tac aac agc acc aac gtg cag acc aac ctg gac cgc atg 12356 Val Ala Arg Tyr Asn Ser Thr Asn Val Gln Thr Asn Leu Asp Arg Met 860 865 870 875 gtg acc gac gtg cgc gag gcc gtg gcc cag cgc gag cgg ttc cac cgc 12404 Val Thr Asp Val Arg Glu Ala Val Ala Gln Arg Glu Arg Phe His Arg 880 885 890 gag tcc aac ctg gga tcc atg gtg gcg ctg aac gcc ttc ctc agc acc 12452 Glu Ser Asn Leu Gly Ser Met Val Ala Leu Asn Ala Phe Leu Ser Thr 895 900 905 cag ccc gcc aac gtg ccc cgg ggc cag gag gac tac acc aac ttc atc 12500 Gln Pro Ala Asn Val Pro Arg Gly Gln Glu Asp Tyr Thr Asn Phe Ile 910 915 920 agc gcc ctg cgc ctg atg gtg acc gag gtg ccc cag agc gag gtg tac 12548 Ser Ala Leu Arg Leu Met Val Thr Glu Val Pro Gln Ser Glu Val Tyr 925 930 935 cag tcc ggg ccg gac tac ttc ttc cag acc agt cgc cag ggc ttg cag 12596 Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr Ser Arg Gln Gly Leu Gln 940 945 950 955 acc gtg aac ctg agc cag gcg ttc aag aac ttg cag ggc ctg tgg ggc 12644 Thr Val Asn Leu Ser Gln Ala Phe Lys Asn Leu Gln Gly Leu Trp Gly 960 965 970 gtg cag gcc ccg gtc ggg gac cgc gcg acg gtg tcg agc ctg ctg acg 12692 Val Gln Ala Pro Val Gly Asp Arg Ala Thr Val Ser Ser Leu Leu Thr 975 980 985 ccg aac tcg cgc ctg ctg ctg ctg ctg gtg gcc ccc ttc acg gac agc 12740 Pro Asn Ser Arg Leu Leu Leu Leu Leu Val Ala Pro Phe Thr Asp Ser 990 995 1000 ggc agc atc aac cgc aac tcg tac ctg ggc tac ctg att aac ctg 12785 Gly Ser Ile Asn Arg Asn Ser Tyr Leu Gly Tyr Leu Ile Asn Leu 1005 1010 1015 tac cgc gag gcc atc ggc cag gcg cac gtg gac gag cag acc tac 12830 Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp Glu Gln Thr Tyr 1020 1025 1030 cag gag atc acc cac gtg agc cgc gcc ctg ggc cag gac gac ccg 12875 Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly Gln Asp Asp Pro 1035 1040 1045 ggc aat ctg gaa gcc acc ctg aac ttt ttg ctg acc aac cgg tcg 12920 Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr Asn Arg Ser 1050 1055 1060 cag aag atc ccg ccc cag tac acg ctc agc gcc gag gag gag cgc 12965 Gln Lys Ile Pro Pro Gln Tyr Thr Leu Ser Ala Glu Glu Glu Arg 1065 1070 1075 atc ctg cga tac gtg cag cag agc gtg ggc ctg ttc ctg atg cag 13010 Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met Gln 1080 1085 1090 gag ggg gcc acc ccc agc gcc gcg ctc gac atg acc gcg cgc aac 13055 Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn 1095 1100 1105 atg gag ccc agc atg tac gcc agc aac cgc ccg ttc atc aat aaa 13100 Met Glu Pro Ser Met Tyr Ala Ser Asn Arg Pro Phe Ile Asn Lys 1110 1115 1120 ctg atg gac tac ttg cat cgg gcg gcc gcc atg aac tct gac tat 13145 Leu Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr 1125 1130 1135 ttc acc aac gcc atc ctg aat ccc cac tgg ctc ccg ccg ccg ggg 13190 Phe Thr Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly 1140 1145 1150 ttc tac acg ggc gag tac gac atg ccc gac ccc aat gac ggg ttc 13235 Phe Tyr Thr Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe 1155 1160 1165 ctg tgg gac gat gtg gac agc agc gtg ttc tcc ccc cga ccg ggt 13280 Leu Trp Asp Asp Val Asp Ser Ser Val Phe Ser Pro Arg Pro Gly 1170 1175 1180 gct aac gag cgc ccc ttg tgg aag aag gaa ggc agc gac cga cgc 13325 Ala Asn Glu Arg Pro Leu Trp Lys Lys Glu Gly Ser Asp Arg Arg 1185 1190 1195 ccg tcc tcg gcg ctg tcc ggc cgc gag ggt gct gcc gcg gcg gtg 13370 Pro Ser Ser Ala Leu Ser Gly Arg Glu Gly Ala Ala Ala Ala Val 1200 1205 1210 ccc gag gcc gcc agt cct ttc ccg agc ttg ccc ttc tcg ctg aac 13415 Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu Pro Phe Ser Leu Asn 1215 1220 1225 agt att cgc agc agc gag ctg ggc agg atc acg cgc ccg cgc ttg 13460 Ser Ile Arg Ser Ser Glu Leu Gly Arg Ile Thr Arg Pro Arg Leu 1230 1235 1240 ctg ggc gag gag gag tac ttg aat gac tcg ctg ttg aga ccc gag 13505 Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu Arg Pro Glu 1245 1250 1255 cgg gag aag aac ttc ccc aat aac ggg ata gag agc ctg gtg gac 13550 Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu Val Asp 1260 1265 1270 aag atg agc cgc tgg aag acg tat gcg cag gag cac agg gac gat 13595 Lys Met Ser Arg Trp Lys Thr Tyr Ala Gln Glu His Arg Asp Asp 1275 1280 1285 ccg tcg cag ggg gcc acg agc cgg ggc agc gcc gcc cgt aaa cgc 13640 Pro Ser Gln Gly Ala Thr Ser Arg Gly Ser Ala Ala Arg Lys Arg 1290 1295 1300 cgg tgg cac gac agg cag cgg gga ctg atg tgg gac gat gag gat 13685 Arg Trp His Asp Arg Gln Arg Gly Leu Met Trp Asp Asp Glu Asp 1305 1310 1315 tcc gcc gac gac agc agc gtg ttg gac ttg ggt ggg agt ggt aac 13730 Ser Ala Asp Asp Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Asn 1320 1325 1330 ccg ttc gct cac ctg cgc ccc cgc atc ggg cgc atg atg taagagaaac 13779 Pro Phe Ala His Leu Arg Pro Arg Ile Gly Arg Met Met 1335 1340 1345 cgaaaataaa tgatactcac caaggccatg gcgaccagcg tgcgttcgtt tcttctctgt 13839 tgttgtatct agt atg atg agg cgt gcg tac ccg gag ggt cct cct ccc 13888 Met Met Arg Arg Ala Tyr Pro Glu Gly Pro Pro Pro 1350 1355 tcg tac gag agc gtg atg cag cag gcg atg gcg gcg gcg gcg gcg 13933 Ser Tyr Glu Ser Val Met Gln Gln Ala Met Ala Ala Ala Ala Ala 1360 1365 1370 atg cag ccc ccg ctg gag gct cct tac gtg ccc ccg cgg tac ctg 13978 Met Gln Pro Pro Leu Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu 1375 1380 1385 gcg cct acg gag ggg cgg aac agc att cgt tac tcg gag ctg gca 14023 Ala Pro Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala 1390 1395 1400 ccc ttg tac gat acc acc cgg ttg tac ctg gtg gac aac aag tcg 14068 Pro Leu Tyr Asp Thr Thr Arg Leu Tyr Leu Val Asp Asn Lys Ser 1405 1410 1415 gcg gac atc gcc tcg ctg aac tac cag aac gac cac agc aac ttc 14113 Ala Asp Ile Ala Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe 1420 1425 1430 ctg acc acc gtg gtg cag aac aat gac ttc acc ccc acg gag gcc 14158 Leu Thr Thr Val Val Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala 1435 1440 1445 agc acc cag acc atc aac ttt gac gag cgc tcg cgg tgg ggc ggt 14203 Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly 1450 1455 1460 cag ctg aaa acc atc atg cac acc aac atg ccc aac gtg aac gag 14248 Gln Leu Lys Thr Ile Met His Thr Asn Met Pro Asn Val Asn Glu 1465 1470 1475 ttc atg tac agc aac aag ttc aag gcg cgg gtg atg gtc tcc cgc 14293 Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser Arg 1480 1485 1490 aag acc ccc aac ggg gtg aca gtg aca gat ggt agt cag gat atc 14338 Lys Thr Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln Asp Ile 1495 1500 1505 ttg gag tat gaa tgg gtg gag ttt gag ctg ccc gaa ggc aac ttc 14383 Leu Glu Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn Phe 1510 1515 1520 tcg gtg acc atg acc atc gac ctg atg aac aac gcc atc atc gac 14428 Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp 1525 1530 1535 aat tac ttg gcg gtg ggg cgg cag aac ggg gtc ctg gag agc gat 14473 Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp 1540 1545 1550 atc ggc gtg aag ttc gac act agg aac ttc agg ctg ggc tgg gac 14518 Ile Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp 1555 1560 1565 ccc gtg acc gag ctg gtc atg ccc ggg gtg tac acc aac gag gcc 14563 Pro Val Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala 1570 1575 1580 ttc cac ccc gat att gtc ttg ctg ccc ggc tgc ggg gtg gac ttc 14608 Phe His Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe 1585 1590 1595 acc gag agc cgc ctc agc aac ctg ctg ggc att cgc aag agg cag 14653 Thr Glu Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln 1600 1605 1610 ccc ttc cag gag ggc ttc cag atc atg tac gag gat ctg gag ggg 14698 Pro Phe Gln Glu Gly Phe Gln Ile Met Tyr Glu Asp Leu Glu Gly 1615 1620 1625 ggc aac atc ccc gcg ctc ctg gat gtc gac gcc tat gag aaa agc 14743 Gly Asn Ile Pro Ala Leu Leu Asp Val Asp Ala Tyr Glu Lys Ser 1630 1635 1640 aag gag gag agc gcc gcc gcg gcg act gca gct gta gcc acc gcc 14788 Lys Glu Glu Ser Ala Ala Ala Ala Thr Ala Ala Val Ala Thr Ala 1645 1650 1655 tct acc gag gtc agg ggc gat aat ttt gcc agc cct gca gca gtg 14833 Ser Thr Glu Val Arg Gly Asp Asn Phe Ala Ser Pro Ala Ala Val 1660 1665 1670 gca gcg gcc gag gcg gct gaa acc gaa agt aag ata gtc att cag 14878 Ala Ala Ala Glu Ala Ala Glu Thr Glu Ser Lys Ile Val Ile Gln 1675 1680 1685 ccg gtg gag aag gat agc aag gac agg agc tac aac gtg ctg ccg 14923 Pro Val Glu Lys Asp Ser Lys Asp Arg Ser Tyr Asn Val Leu Pro 1690 1695 1700 gac aag ata aac acc gcc tac cgc agc tgg tac ctg gcc tac aac 14968 Asp Lys Ile Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn 1705 1710 1715 tat ggc gac ccc gag aag ggc gtg cgc tcc tgg acg ctg ctc acc 15013 Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu Thr 1720 1725 1730 acc tcg gac gtc acc tgc ggc gtg gag caa gtc tac tgg tcg ctg 15058 Thr Ser Asp Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser Leu 1735 1740 1745 ccc gac atg atg caa gac ccg gtc acc ttc cgc tcc acg cgt caa 15103 Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln 1750 1755 1760 gtt agc aac tac ccg gtg gtg ggc gcc gag ctc ctg ccc gtc tac 15148 Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val Tyr 1765 1770 1775 tcc aag agc ttc ttc aac gag cag gcc gtc tac tcg cag cag ctg 15193 Ser Lys Ser Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu 1780 1785 1790 cgc gcc ttc acc tcg ctc acg cac gtc ttc aac cgc ttc ccc gag 15238 Arg Ala Phe Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu 1795 1800 1805 aac cag atc ctc gtc cgc ccg ccc gcg ccc acc att acc acc gtc 15283 Asn Gln Ile Leu Val Arg Pro Pro Ala Pro Thr Ile Thr Thr Val 1810 1815 1820 agt gaa aac gtt cct gct ctc aca gat cac ggg acc ctg ccg ctg 15328 Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu 1825 1830 1835 cgc agc agt atc cgg gga gtc cag cgc gtg acc gtt act gac gcc 15373 Arg Ser Ser Ile Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala 1840 1845 1850 aga cgc cgc acc tgc ccc tac gtc tac aag gcc ctg ggc ata gtc 15418 Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val 1855 1860 1865 gcg ccg cgc gtc ctc tcg agc cgc acc ttc taaaaa atg tcc att ctc 15466 Ala Pro Arg Val Leu Ser Ser Arg Thr Phe Met Ser Ile Leu 1870 1875 1880 atc tcg ccc agt aat aac acc ggt tgg ggc ctg cgc gcg ccc agc 15511 Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg Ala Pro Ser 1885 1890 1895 aag atg tac gga ggc gct cgc caa cgc tcc acg caa cac ccc gtg 15556 Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His Pro Val 1900 1905 1910 cgc gtg cgc ggg cac ttc cgc gct ccc tgg ggc gcc ctc aag ggc 15601 Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys Gly 1915 1920 1925 cgc gtg cgg tcg cgc acc acc gtc gac gac gtg atc gac cag gtg 15646 Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 1930 1935 1940 gtg gcc gac gcg cgc aac tac acc ccc gcc gcc gcg ccc gtc tcc 15691 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Val Ser 1945 1950 1955 acc gtg gac gcc gtc atc gac agc gtg gtg gcc gac gcg cgc cgg 15736 Thr Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg 1960 1965 1970 tac gcc cgc gcc aag agc cgg cgg cgg cgc atc gcc cgg cgg cac 15781 Tyr Ala Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His 1975 1980 1985 cgg agc acc ccc gcc atg cgc gcg gcg cga gcc ttg ctg cgc agg 15826 Arg Ser Thr Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg 1990 1995 2000 gcc agg cgc acg gga cgc agg gcc atg ctc agg gcg gcc aga cgc 15871 Ala Arg Arg Thr Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg 2005 2010 2015 gcg gcc tca ggc gcc agc gcc ggc agg acc cgg aga cgc gcg gcc 15916 Ala Ala Ser Gly Ala Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala 2020 2025 2030 acg gcg gcg gca gcg gcc atc gcc agc atg tcc cgc ccg cgg cga 15961 Thr Ala Ala Ala Ala Ala Ile Ala Ser Met Ser Arg Pro Arg Arg 2035 2040 2045 ggg aac gtg tac tgg gtg cgc gac gcc gcc acc ggt gtg cgc gtg 16006 Gly Asn Val Tyr Trp Val Arg Asp Ala Ala Thr Gly Val Arg Val 2050 2055 2060 ccc gtg cgc acc cgc ccc cct cgc act tgaagatgtt cacttcgcga 16053 Pro Val Arg Thr Arg Pro Pro Arg Thr 2065 2070 tgttgatgtg tcccagcggc gagg atg tcc aag cgc aaa ttc aag gaa gag 16104 Met Ser Lys Arg Lys Phe Lys Glu Glu 2075 2080 atg ctc cag gtc atc gcg cct gag atc tac ggc ccc gcg gtg gtg 16149 Met Leu Gln Val Ile Ala Pro Glu Ile Tyr Gly Pro Ala Val Val 2085 2090 2095 aag gag gaa aga aag ccc cgc aaa atc aag cgg gtc aaa aag gac 16194 Lys Glu Glu Arg Lys Pro Arg Lys Ile Lys Arg Val Lys Lys Asp 2100 2105 2110 aaa aag gaa gaa gaa agt gat gtg gac gga ctg gtg gag ttt gtg 16239 Lys Lys Glu Glu Glu Ser Asp Val Asp Gly Leu Val Glu Phe Val 2115 2120 2125 cgc gag ttc gcc ccc cgg cgg cgc gtg cag tgg cgc ggg cgg aag 16284 Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp Arg Gly Arg Lys 2130 2135 2140 gtg cgc ccg gtg ctg aga cca ggc act acg gtg gtc ttc acg ccc 16329 Val Arg Pro Val Leu Arg Pro Gly Thr Thr Val Val Phe Thr Pro 2145 2150 2155 ggc gag cgc tcc ggc acc gct tcc aag cgc tcc tac gac gag gtg 16374 Gly Glu Arg Ser Gly Thr Ala Ser Lys Arg Ser Tyr Asp Glu Val 2160 2165 2170 tac ggg gac gag gac atc ctc gag cag gcg gcc gag cgc ctg ggc 16419 Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu Gly 2175 2180 2185 gag ttt gct tac ggc aag cgc agc cgc tcc gcg ccg aag gaa gag 16464 Glu Phe Ala Tyr Gly Lys Arg Ser Arg Ser Ala Pro Lys Glu Glu 2190 2195 2200 gcg gtg tcc atc ccg ctg gac cac ggc aac ccc acg ccg agc ctc 16509 Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu 2205 2210 2215 aag ccc gtg acc ctg cag cag gtg ctg ccg acc gcg gcg ccg cgc 16554 Lys Pro Val Thr Leu Gln Gln Val Leu Pro Thr Ala Ala Pro Arg 2220 2225 2230 cgg ggg ttc aag cgc gag ggc gag gat ctg tac ccc acc atg cag 16599 Arg Gly Phe Lys Arg Glu Gly Glu Asp Leu Tyr Pro Thr Met Gln 2235 2240 2245 ctg atg gtg ccc aag cgc cag aag ctg gaa gac gtg ctg gag acc 16644 Leu Met Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu Thr 2250 2255 2260 atg aag gtg gac ccg gac gtg cag ccc gag gtc aag gtg cgg ccc 16689 Met Lys Val Asp Pro Asp Val Gln Pro Glu Val Lys Val Arg Pro 2265 2270 2275 atc aag cag gtg gcc ccg ggc ctg ggc gtg cag acc gtg gac atc 16734 Ile Lys Gln Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile 2280 2285 2290 aag atc ccc acg gag ccc atg gaa acg cag acc gag ccc gtg aaa 16779 Lys Ile Pro Thr Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys 2295 2300 2305 ccc agc acc agc acc atg gag gtg cag acg gat cct tgg atg cca 16824 Pro Ser Thr Ser Thr Met Glu Val Gln Thr Asp Pro Trp Met Pro 2310 2315 2320 tcg gct act agc cga aga ccc cgg cgc aag tac ggc gcg gcc agc 16869 Ser Ala Thr Ser Arg Arg Pro Arg Arg Lys Tyr Gly Ala Ala Ser 2325 2330 2335 ctg ctg atg ccc aac tac gcg ctg cat cct tcc atc atc ccc acg 16914 Leu Leu Met Pro Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr 2340 2345 2350 ccg ggc tac cgc ggc acg cgc ttc tac cgc ggt cat aca agc cgc 16959 Pro Gly Tyr Arg Gly Thr Arg Phe Tyr Arg Gly His Thr Ser Arg 2355 2360 2365 cgc cgc aag acc acc acc cgc cgc cgc cgt cgc cgc aca acc gct 17004 Arg Arg Lys Thr Thr Thr Arg Arg Arg Arg Arg Arg Thr Thr Ala 2370 2375 2380 gct gca tct acc cct gcc gcc ctg gtg cgg aga gtg tac cgc cgc 17049 Ala Ala Ser Thr Pro Ala Ala Leu Val Arg Arg Val Tyr Arg Arg 2385 2390 2395 ggc cgc gcg cct ctg acc ctg ccg cgc gcg cgc tac cac ccg agc 17094 Gly Arg Ala Pro Leu Thr Leu Pro Arg Ala Arg Tyr His Pro Ser 2400 2405 2410 att gcc att taaactttcg cctgctttgc agatca atg gcc ctc aca tgc cgc 17147 Ile Ala Ile Met Ala Leu Thr Cys Arg 2415 ctc cgc gtt ccc att acg ggc tac cga gga aga aaa ccg cgc cgt 17192 Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly Arg Lys Pro Arg Arg 2420 2425 2430 aga agg ctg gcg ggg aac ggg atg cgt cgc cac cac cac cgg cgg 17237 Arg Arg Leu Ala Gly Asn Gly Met Arg Arg His His His Arg Arg 2435 2440 2445 cgg cgc gcc atc agc aag cgg ttg ggg gga ggc ttc ctg ccc gcg 17282 Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe Leu Pro Ala 2450 2455 2460 ctg atc ccc atc atc gcc gcg gcg atc ggg gcg atc ccc ggc att 17327 Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro Gly Ile 2465 2470 2475 gct tcc gtg gcg gtg cag gcc tct cag cgc cac tgagacacac 17370 Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 2480 2485 2490 ttggaaacat cttgtaataa acca atg gac tct gac gct cct ggt cct gtg 17421 Met Asp Ser Asp Ala Pro Gly Pro Val 2495 atg tgt ttt cgt aga cag atg gaa gac atc aat ttt tcg tcc ctg 17466 Met Cys Phe Arg Arg Gln Met Glu Asp Ile Asn Phe Ser Ser Leu 2500 2505 2510 gct ccg cga cac ggc acg cgg ccg ttc atg ggc acc tgg agc gac 17511 Ala Pro Arg His Gly Thr Arg Pro Phe Met Gly Thr Trp Ser Asp 2515 2520 2525 atc ggc acc agc caa ctg aac ggg ggc gcc ttc aat tgg agc agt 17556 Ile Gly Thr Ser Gln Leu Asn Gly Gly Ala Phe Asn Trp Ser Ser 2530 2535 2540 ctc tgg agc ggg ctt aag aat ttc ggg tcc acg ctt aaa acc tat 17601 Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser Thr Leu Lys Thr Tyr 2545 2550 2555 ggc agc aag gcg tgg aac agc acc aca ggg cag gcg ctg agg gat 17646 Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly Gln Ala Leu Arg Asp 2560 2565 2570 aag ctg aaa gag cag aac ttc cag cag aag gtg gtc gat ggc ctg 17691 Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val Val Asp Gly Leu 2575 2580 2585 gcc tcg ggc atc aac ggg gtg gtg gac ctg gcc aac cag gcc gtg 17736 Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn Gln Ala Val 2590 2595 2600 cag cgg cag atc aac agc cgc ctg gac ccg gtg ccg ccc gcc ggc 17781 Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro Ala Gly 2605 2610 2615 tcc gtg gag atg ccg cag gtg gag gag gag ctg cct ccc ctg gac 17826 Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu Asp 2620 2625 2630 aag cgg ggc gag aag cga ccc cgc ccc gac gcg gag gag acg ctg 17871 Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu 2635 2640 2645 ctg acg cac acg gac gag ccg ccc ccg tac gag gag gcg gtg aaa 17916 Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys 2650 2655 2660 ctg ggc ctg ccc acc acg cgg ccc atc gcg cct ctg gcc acc ggg 17961 Leu Gly Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly 2665 2670 2675 gtg ctg aaa ccc gaa agt agt aag ccc gcg acc ctg gac ttg cct 18006 Val Leu Lys Pro Glu Ser Ser Lys Pro Ala Thr Leu Asp Leu Pro 2680 2685 2690 cct ccc cag cct tcc cgc ccc tcc aca gtg gct aag cct ctg ccg 18051 Pro Pro Gln Pro Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro 2695 2700 2705 ccg gtg gcc gtg gcc cgc gcg cga ccc ggg ggc acc gcc cgc cct 18096 Pro Val Ala Val Ala Arg Ala Arg Pro Gly Gly Thr Ala Arg Pro 2710 2715 2720 cat gcg aac tgg cag agc act ctg aac agc atc gtg ggt ctg gga 18141 His Ala Asn Trp Gln Ser Thr Leu Asn Ser Ile Val Gly Leu Gly 2725 2730 2735 gtg cag agt gtg aag cgc cgc cgc tgc tat taaacctacc gtagcgctta 18191 Val Gln Ser Val Lys Arg Arg Arg Cys Tyr 2740 2745 acttgcttgt ctgtgtgtgt atgtattatg tcgccgccgc tgtcgccaga aggaggagtg 18251 aagaggcgcg tcgccgagtt gcaag atg gcc acc cca tcg atg ctg ccc cag 18303 Met Ala Thr Pro Ser Met Leu Pro Gln 2750 2755 tgg gcg tac atg cac atc gcc gga cag gac gct tcg gag tac ctg 18348 Trp Ala Tyr Met His Ile Ala Gly Gln Asp Ala Ser Glu Tyr Leu 2760 2765 2770 agt ccg ggt ctg gtg cag ttc gcc cgc gcc aca gac acc tac ttc 18393 Ser Pro Gly Leu Val Gln Phe Ala Arg Ala Thr Asp Thr Tyr Phe 2775 2780 2785 agt ctg ggg aac aag ttt agg aac ccc acg gtg gcg ccc acg cac 18438 Ser Leu Gly Asn Lys Phe Arg Asn Pro Thr Val Ala Pro Thr His 2790 2795 2800 gat gtg acc acc gac cgc agc cag cgg ctg acg ctg cgc ttc gtg 18483 Asp Val Thr Thr Asp Arg Ser Gln Arg Leu Thr Leu Arg Phe Val 2805 2810 2815 ccc gtg gac cgc gag gac aac acc tac tcg tac aaa gtg cgc tac 18528 Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr Lys Val Arg Tyr 2820 2825 2830 acg ctg gcc gtg ggc gac aac cgc gtg ctg gac atg gcc agc acc 18573 Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met Ala Ser Thr 2835 2840 2845 tac ttt gac atc cgc ggc gtg ctg gac cgg ggc cct agc ttc aaa 18618 Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser Phe Lys 2850 2855 2860 ccc tac tcc ggc acc gcc tac aat gct ctg gcc ccc aag gga gca 18663 Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly Ala 2865 2870 2875 ccc aac act tgc cag tgg aca tac aca gat aag caa acc gaa aaa 18708 Pro Asn Thr Cys Gln Trp Thr Tyr Thr Asp Lys Gln Thr Glu Lys 2880 2885 2890 aca gcc acg tat ggg aat gcg cct gta caa ggc att gcc atc aca 18753 Thr Ala Thr Tyr Gly Asn Ala Pro Val Gln Gly Ile Ala Ile Thr 2895 2900 2905 aaa gat ggt att caa ctt gga act gac agt gat gga aat cct gta 18798 Lys Asp Gly Ile Gln Leu Gly Thr Asp Ser Asp Gly Asn Pro Val 2910 2915 2920 tat gct caa aag aca ttt gaa ccc gaa cct caa gtg ggt gat gca 18843 Tyr Ala Gln Lys Thr Phe Glu Pro Glu Pro Gln Val Gly Asp Ala 2925 2930 2935 gaa tgg cat gac act aca ggt aca gat gaa aag tat gga ggc agg 18888 Glu Trp His Asp Thr Thr Gly Thr Asp Glu Lys Tyr Gly Gly Arg 2940 2945 2950 gca ctt aag cct gac acc aaa atg aag cct tgc tat ggt tct ttt 18933 Ala Leu Lys Pro Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe 2955 2960 2965 gcc aaa ccc act aac aaa gaa ggt gga cag gca aag aac aga aca 18978 Ala Lys Pro Thr Asn Lys Glu Gly Gly Gln Ala Lys Asn Arg Thr 2970 2975 2980 aaa act gat gga act ggc gaa gag cct gat att gat atg gca ttt 19023 Lys Thr Asp Gly Thr Gly Glu Glu Pro Asp Ile Asp Met Ala Phe 2985 2990 2995 ttt gac ggc aga aat gca act aca gct ggt ttg gct cca gaa att 19068 Phe Asp Gly Arg Asn Ala Thr Thr Ala Gly Leu Ala Pro Glu Ile 3000 3005 3010 gtt ttg tat act gag aat gtg gat ctg gag act cca gat acc cat 19113 Val Leu Tyr Thr Glu Asn Val Asp Leu Glu Thr Pro Asp Thr His 3015 3020 3025 att gta tac aaa gca ggc aca gat gac agc agc tct tcg att aat 19158 Ile Val Tyr Lys Ala Gly Thr Asp Asp Ser Ser Ser Ser Ile Asn 3030 3035 3040 ttg ggg cag caa tcc atg ccc aac aga ccc aac tac att ggg ttc 19203 Leu Gly Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe 3045 3050 3055 aga gac aac ttt atc ggg ctc atg tac tac aac agc act ggc aat 19248 Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn 3060 3065 3070 atg ggg gtg ctg gcc ggt cag gct tct cag ctg aat gct gtg gtt 19293 Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val 3075 3080 3085 gac ttg caa gac aga aac acc gaa ctg tcc tac cag ctc ttg ctt 19338 Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu 3090 3095 3100 gac tct ctg ggc gac aga acc ctg tat ttc agt atg tgg aat cag 19383 Asp Ser Leu Gly Asp Arg Thr Leu Tyr Phe Ser Met Trp Asn Gln 3105 3110 3115 gcg gtg gac agc tat gat cct gat gtg cgc att att gaa aac cat 19428 Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His 3120 3125 3130 ggt gtg gaa gat gaa ctt ccc aac tat tgc ttc cct ctg gat gct 19473 Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asp Ala 3135 3140 3145 gtt ggt agg aca gat act tat cag gga att aag ccc aat gga ggc 19518 Val Gly Arg Thr Asp Thr Tyr Gln Gly Ile Lys Pro Asn Gly Gly 3150 3155 3160 gat cca gcc aca tgg gcc aaa gat gac agc gcc aat gat gct aat 19563 Asp Pro Ala Thr Trp Ala Lys Asp Asp Ser Ala Asn Asp Ala Asn 3165 3170 3175 gaa atg ggc aag ggc aat cca ttc gcc atg gaa atc aac atc caa 19608 Glu Met Gly Lys Gly Asn Pro Phe Ala Met Glu Ile Asn Ile Gln 3180 3185 3190 gcc aac ctg tgg agg aac ttc ctc tac gcc aac gtg gcc ctg tac 19653 Ala Asn Leu Trp Arg Asn Phe Leu Tyr Ala Asn Val Ala Leu Tyr 3195 3200 3205 cta ccc gat tct tac aag tac acg ccg gcc aac gtc acc ctg ccc 19698 Leu Pro Asp Ser Tyr Lys Tyr Thr Pro Ala Asn Val Thr Leu Pro 3210 3215 3220 acc aac acc aac acc tac gat tat atg aac ggc cgg gtg gtg gcg 19743 Thr Asn Thr Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val Val Ala 3225 3230 3235 cct tcg ctg gtg gac tcc tac atc aac atc ggg gcg cgc tgg tcg 19788 Pro Ser Leu Val Asp Ser Tyr Ile Asn Ile Gly Ala Arg Trp Ser 3240 3245 3250 ctg gac ccc atg gac aac gtc aat ccc ttc aac cac cac cgc aac 19833 Leu Asp Pro Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn 3255 3260 3265 gcg ggc ttg cgc tac cgc tcc atg ctc ctg ggc aac ggg cgc tac 19878 Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr 3270 3275 3280 gtg ccc ttc cac atc cag gtg ccc cag aaa ttt ttc gcc atc aag 19923 Val Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys 3285 3290 3295 agc ctc ctg ctc ctg ccc ggg tcc tac acc tac gag tgg aac ttc 19968 Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe 3300 3305 3310 cgc aag gac gtc aac atg atc ctg cag agc tcc ctc ggc aac gac 20013 Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp 3315 3320 3325 ctg cgc acg gac ggg gcc tcc atc tcc ttc acc agc atc aac ctc 20058 Leu Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu 3330 3335 3340 tac gcc acc ttc ttc ccc atg gcg cac aac acg gcc tcc acg ctc 20103 Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu 3345 3350 3355 gag gcc atg ctg cgc aac gac acc aac gac cag tcc ttc aac gac 20148 Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp 3360 3365 3370 tac ctc tcg gcg gcc aac atg ctc tac ccc atc ccg gcc aac gcc 20193 Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala 3375 3380 3385 acc aac gtg ccc atc tcc atc ccc tcg cgc aac tgg gcc gcc ttc 20238 Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe 3390 3395 3400 cgc ggc tgg tcc ttc acg cgc ctc aag acc aag gag acg ccc tcg 20283 Arg Gly Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser 3405 3410 3415 ctg ggc tcc ggg ttc gac ccc tac ttc gtc tac tcg ggc tcc atc 20328 Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile 3420 3425 3430 ccc tac ctc gac ggc acc ttc tac ctc aac cac acc ttc aag aag 20373 Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys 3435 3440 3445 gtc tcc atc acc ttc gac tcc tcc gtc agc tgg ccc ggc aac gac 20418 Val Ser Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp 3450 3455 3460 cgg ctc ctg acg ccc aac gag ttc gaa atc aag cgc acc gtc gac 20463 Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp 3465 3470 3475 ggc gag ggc tac aac gtg gcc cag tgc aac atg acc aag gac tgg 20508 Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp 3480 3485 3490 ttc ctg gtc cag atg ctg gcc cac tac aac atc ggc tac cag ggc 20553 Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly 3495 3500 3505 ttc tac gtg ccc gag ggc tac aag gac cgc atg tac tcc ttc ttc 20598 Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe 3510 3515 3520 cgc aac ttc cag ccc atg agc cgc cag gtg gtg gac gag gtc aac 20643 Arg Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Val Asn 3525 3530 3535 tac aag gac tac cag gcc gtc acc ctg gcc tac cag cac aac aac 20688 Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn Asn 3540 3545 3550 tcg ggc ttc gtc ggc tac ctc gcg ccc acc atg cgc cag ggc cag 20733 Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln 3555 3560 3565 ccc tac ccc gcc aac tac ccg tac ccg ctc atc ggc aag agc gcc 20778 Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala 3570 3575 3580 gtc acc agc gtc acc cag aaa aag ttc ctc tgc gac agg gtc atg 20823 Val Thr Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met 3585 3590 3595 tgg cgc atc ccc ttc tcc agc aac ttc atg tcc atg ggc gcg ctc 20868 Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu 3600 3605 3610 acc gac ctc ggc cag aac atg ctc tat gcc aac tcc gcc cac gcg 20913 Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala 3615 3620 3625 cta gac atg aat ttc gaa gtc gac ccc atg gat gag tcc acc ctt 20958 Leu Asp Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu 3630 3635 3640 ctc tat gtt gtc ttc gaa gtc ttc gac gtc gtc cga gtg cac cag 21003 Leu Tyr Val Val Phe Glu Val Phe Asp Val Val Arg Val His Gln 3645 3650 3655 ccc cac cgc ggc gtc atc gag gcc gtc tac ctg cgc acc ccc ttc 21048 Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe 3660 3665 3670 tcg gcc ggt aac gcc acc acc taaattgcta cttgc atg atg gct gag 21096 Ser Ala Gly Asn Ala Thr Thr Met Met Ala Glu 3675 3680 gcc gcg ggc tcc ggc gag cag gag ctc agg gcc atc atc cgc gac 21141 Ala Ala Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile Arg Asp 3685 3690 3695 ctg ggc tgc ggg ccc tac ttc ctg ggc acc ttc gat aag cgc ttc 21186 Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg Phe 3700 3705 3710 ccg gga ttc atg gcc ccg cac aag ctg gcc tgc gcc atc gtc aac 21231 Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn 3715 3720 3725 acg gcc ggt cgc gag acc ggg ggc gag cac tgg ctg gcc ttc gcc 21276 Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala 3730 3735 3740 tgg aac ccg cgc tcg aac acc tgc tac ctc ttc gac ccc ttc ggg 21321 Trp Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly 3745 3750 3755 ttc tcg gac gag cgc ctc aag cag atc tac cag ttc gag tac gag 21366 Phe Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu 3760 3765 3770 ggc ctg ctg cgc cgc agc gcc ctg gcc acc gag gac cgc tgc gtc 21411 Gly Leu Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val 3775 3780 3785 acc ctg gaa aag tcc acc cag acc gtg cag ggt ccg cgc tcg gcc 21456 Thr Leu Glu Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala 3790 3795 3800 gcc tgc ggg ctc ttc tgc tgc atg ttc ctg cac gcc ttc gtg cac 21501 Ala Cys Gly Leu Phe Cys Cys Met Phe Leu His Ala Phe Val His 3805 3810 3815 tgg ccc gac cgc ccc atg gac aag aac ccc acc atg aac ttg ctg 21546 Trp Pro Asp Arg Pro Met Asp Lys Asn Pro Thr Met Asn Leu Leu 3820 3825 3830 acg ggg gtg ccc aac ggc atg ctc cag tcg ccc cag gtg gaa ccc 21591 Thr Gly Val Pro Asn Gly Met Leu Gln Ser Pro Gln Val Glu Pro 3835 3840 3845 acc ctg cgc cgc aac cag gag gcg ctc tac cgc ttc ctc aac tcc 21636 Thr Leu Arg Arg Asn Gln Glu Ala Leu Tyr Arg Phe Leu Asn Ser 3850 3855 3860 cac tcc gcc tac ttt cgc tcc cac cgc gcg cgc atc gag aag gcc 21681 His Ser Ala Tyr Phe Arg Ser His Arg Ala Arg Ile Glu Lys Ala 3865 3870 3875 acc gcc ttc gat cgc atg aac aat caa gac atg taaaccgtgt 21724 Thr Ala Phe Asp Arg Met Asn Asn Gln Asp Met 3880 3885 3890 gtgtatgttt aaaatatctt ttaataaaca gcactttcat gttacacatg catctgagat 21784 gattatttag aaatcgaaag ggttctgccg ggtctcggca tggcccgcgg gcagggacac 21844 gttgcggaac tggtacttgg ccagccactt gaactcgggg atcagcagtt tcggcagcgg 21904 ggtgtcgggg aaggagtcgg tccacagctt ccgcgtcagt tgcagggcgc ccagcaggtc 21964 gggcgcggag atcttgaaat cgcagttggg acccgcgttc tgcgcgcgag agttgcggta 22024 cacggggttg cagcactgga acaccatcag ggccgggtgc ttcacgctcg ccagcaccgt 22084 cgcgtcggtg atgctctcca cgtcgaggtc ctcggcgttg gccatcccga agggggtcat 22144 cttgcaggtc tgccttccca tagtgggcac gcacccgggc ttgtggttgc aatcgcagtg 22204 cagggggatc agcatcatct gggcctggtc ggcgttcatc cccgggtaca tggccttcat 22264 gaaagcctcc aattgcctga aagcctgctg ggccttggct ccctcggtga agaagacccc 22324 gcaggacttg ctagagaact ggttggtagc gcacccggcg tcgtgcacgc agcagcgcgc 22384 gtcgttgttg gccagctgca ccacgctgcg cccccagcgg ttctgggtga tcttggcccg 22444 gtcggggttc tccttcagcg cgcgctgccc gttctcgctc gccacatcca tctcgatcat 22504 gtgctccttc tggatcatgg tggtcccgtg caggcaccgc agcttgccct cggtctcggt 22564 gcacccgtgc agccacagcg cgcacccggt gcactcccag ttcttgtggg cgatctggga 22624 atgcgcgtgc acgaacccct gcaggaagcg gcccatcatg gtggtcaggg tcttgttgct 22684 agtgaaggtc agcgggatgc cgcggtgctc ctcgttgatg tacaggtggc agatgcggcg 22744 gtacacctcg ccctgctcgg gcatcagctg gaagttggct ttcaggtcgg tctccacgcg 22804 gtagcggtcc atcagtatag tcatgatttc catacccttc tcccaggccg agacgatggg 22864 caggctcata gggttcttca ccatcatctt agcactagca gccgcggcca gggggtcgct 22924 ctcatccagg gtctcaaagc tccgcttgcc gtccttctcg gtgatccgca ccggggggta 22984 gctgaagccc acggccgcca gctcctcctc ggcctgcctt tcgtcctcgc tgtcctggct 23044 gacgtcctgc aggaccacat gcttggtctt gcggggtttc ttcttgggcg gcagcggcgg 23104 cggagatgct tgtggcgagg gggagcgcga gttctcgctc accactacta tctcttcctc 23164 ttcgtggtcc gaggccacgc ggcggtaggt atgtctcttc gggggcagag gcggaggcga 23224 cgggctctcg ccgccgcgac ttggcggatg gctggcagag ccccttccgc gatcgggggt 23284 gcgctcccgg cggcgctctg actgacttcc tccgcggccg gccattgtgt tctcctaggg 23344 aggaacaaca agc atg gag act cag cca tcg cca acc tcg cca tct gcc 23393 Met Glu Thr Gln Pro Ser Pro Thr Ser Pro Ser Ala 3895 3900 ccc acc acc gcc gac gag aag cag cag aat gaa agc tta acc gcc 23438 Pro Thr Thr Ala Asp Glu Lys Gln Gln Asn Glu Ser Leu Thr Ala 3905 3910 3915 ccg ccg ccc agc ccc gcc acc tcc gac gca gcc gcg gtc cca gac 23483 Pro Pro Pro Ser Pro Ala Thr Ser Asp Ala Ala Ala Val Pro Asp 3920 3925 3930 atg caa gag atg gag gaa tcc atc gag att gac ctg ggc tat gtg 23528 Met Gln Glu Met Glu Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val 3935 3940 3945 acg ccc gcg gag cac gag gag gag ctg gca gtg cgc ttt caa tcg 23573 Thr Pro Ala Glu His Glu Glu Glu Leu Ala Val Arg Phe Gln Ser 3950 3955 3960 tca agc cag gaa gat aaa gaa cag cca gag cag gaa gca gaa aac 23618 Ser Ser Gln Glu Asp Lys Glu Gln Pro Glu Gln Glu Ala Glu Asn 3965 3970 3975 gag cag agt cag gct ggg ctc gag cat gac ggc gac tac ctc cac 23663 Glu Gln Ser Gln Ala Gly Leu Glu His Asp Gly Asp Tyr Leu His 3980 3985 3990 ctg agc ggg gag gag gac gcg ctc atc aag cat ctg gcc cgg cag 23708 Leu Ser Gly Glu Glu Asp Ala Leu Ile Lys His Leu Ala Arg Gln 3995 4000 4005 gcc atc atc gtc aag gat gcg ctg ctc gac cgc acc gag gtg ccc 23753 Ala Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Thr Glu Val Pro 4010 4015 4020 ctc agc gtg gag gag ctc agc cgc gcc tac gag ctc aac ctc ttc 23798 Leu Ser Val Glu Glu Leu Ser Arg Ala Tyr Glu Leu Asn Leu Phe 4025 4030 4035 tcg ccg cgc gtg ccc ccc aag cgc cag ccc aac ggc acc tgc gag 23843 Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys Glu 4040 4045 4050 ccc aac ccg cgc ctc aac ttc tac ccg gtc ttc gcg gtg ccc gag 23888 Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu 4055 4060 4065 gcc ctg gcc acc tac cac atc ttt ttc aag aac caa aag atc ccc 23933 Ala Leu Ala Thr Tyr His Ile Phe Phe Lys Asn Gln Lys Ile Pro 4070 4075 4080 gtc tcc tgt cgc gcc aac cgc acc cgc gcc gac gcc ctc ttc aac 23978 Val Ser Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Phe Asn 4085 4090 4095 ctg ggc ccc ggc gcc cgc cta cct gat atc gcc tcc ttg gaa gag 24023 Leu Gly Pro Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu 4100 4105 4110 gtt ccc aag atc ttc gag ggt ctg ggc agc gac gag act cgg gcc 24068 Val Pro Lys Ile Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala 4115 4120 4125 gca aac gct ctg caa gga gaa gga gga gag cat gag cac cac agc 24113 Ala Asn Ala Leu Gln Gly Glu Gly Gly Glu His Glu His His Ser 4130 4135 4140 gcc ctg gtc gag ttg gaa ggc gac aac gcg cgg ctg gcg gtg ctc 24158 Ala Leu Val Glu Leu Glu Gly Asp Asn Ala Arg Leu Ala Val Leu 4145 4150 4155 aaa cgc acg gtc gag ctg acc cat ttc gcc tac ccg gct ctg aac 24203 Lys Arg Thr Val Glu Leu Thr His Phe Ala Tyr Pro Ala Leu Asn 4160 4165 4170 ctg ccc ccc aaa gtc atg agc gcg gtc atg gac cag gtg ctc atc 24248 Leu Pro Pro Lys Val Met Ser Ala Val Met Asp Gln Val Leu Ile 4175 4180 4185 aag cgc gcg tcg ccc atc tcc gag gac gag ggc atg caa gac tcc 24293 Lys Arg Ala Ser Pro Ile Ser Glu Asp Glu Gly Met Gln Asp Ser 4190 4195 4200 gag gat ggc aag ccc gtg gtc agc gac gag cag ctg gcc cgg tgg 24338 Glu Asp Gly Lys Pro Val Val Ser Asp Glu Gln Leu Ala Arg Trp 4205 4210 4215 ctg ggt cct aat gct agt ccc cag agt ttg gaa gag cgg cgc aag 24383 Leu Gly Pro Asn Ala Ser Pro Gln Ser Leu Glu Glu Arg Arg Lys 4220 4225 4230 ctc atg atg gcc gtg gtc ctg gtg acc gtg gag ctg gag tgc ctg 24428 Leu Met Met Ala Val Val Leu Val Thr Val Glu Leu Glu Cys Leu 4235 4240 4245 cgc cgc ttc ttc gcc gac gcg gag acc ctg cgc aag gtc gag gag 24473 Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu Arg Lys Val Glu Glu 4250 4255 4260 aac ctg cac tac ctc ttc agg cac ggg ttc gtg cgc cag gcc tgc 24518 Asn Leu His Tyr Leu Phe Arg His Gly Phe Val Arg Gln Ala Cys 4265 4270 4275 aag atc tcc aac gtg gag ctg acc aac ctg gtc tcc tac atg ggc 24563 Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr Met Gly 4280 4285 4290 atc ttg cac gag aac cgc ctg ggg cag aac gtg ctg cac acc acc 24608 Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr Thr 4295 4300 4305 ctg cgc ggg gag gcc cgc cgc gac tac atc cgc gac tgc gtc tac 24653 Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr 4310 4315 4320 ctc tac ctc tgc cac acc tgg cag acg ggc atg ggc gtg tgg cag 24698 Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln 4325 4330 4335 cag tgt ctg gag gag cag aac ctg aaa gag ctc tgc aag ctc ctg 24743 Gln Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu 4340 4345 4350 cag aag aac ctc aag ggt ctg tgg acc ggg ttc gac gag cgg acc 24788 Gln Lys Asn Leu Lys Gly Leu Trp Thr Gly Phe Asp Glu Arg Thr 4355 4360 4365 acc gcc tcg gac ctg gcc gac ctc atc ttc ccc gag cgc ctc agg 24833 Thr Ala Ser Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg 4370 4375 4380 ctg acg ctg cgc aac ggc ctg ccc gac ttt atg agc caa agc atg 24878 Leu Thr Leu Arg Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met 4385 4390 4395 ttg caa aac ttt cgc tct ttc atc ctc gaa cgc tcc gga atc ctg 24923 Leu Gln Asn Phe Arg Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu 4400 4405 4410 ccc gcc acc tgc tcc gcg ctg ccc tcg gac ttc gtg ccg ctg acc 24968 Pro Ala Thr Cys Ser Ala Leu Pro Ser Asp Phe Val Pro Leu Thr 4415 4420 4425 ttc cgc gag tgc ccc ccg ccg ctg tgg agc cac tgc tac ctg ctg 25013 Phe Arg Glu Cys Pro Pro Pro Leu Trp Ser His Cys Tyr Leu Leu 4430 4435 4440 cgc ctg gcc aac tac ctg gcc tac cac tcg gac gtg atc gag gac 25058 Arg Leu Ala Asn Tyr Leu Ala Tyr His Ser Asp Val Ile Glu Asp 4445 4450 4455 gtc agc ggc gag ggc ctg ctt gag tgc cac tgc cgc tgc aac ctc 25103 Val Ser Gly Glu Gly Leu Leu Glu Cys His Cys Arg Cys Asn Leu 4460 4465 4470 tgc acg ccg cac cgc tcc ctg gcc tgc aac ccc cag ctg ctg agc 25148 Cys Thr Pro His Arg Ser Leu Ala Cys Asn Pro Gln Leu Leu Ser 4475 4480 4485 gag acc cag atc atc ggc acc ttc gag ttg caa ggg ccc agc gat 25193 Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln Gly Pro Ser Asp 4490 4495 4500 gac ggc gag gga gcc aag ggg ggt ctg aaa ctc acc ccg ggg ctg 25238 Asp Gly Glu Gly Ala Lys Gly Gly Leu Lys Leu Thr Pro Gly Leu 4505 4510 4515 tgg acc tcg gcc tac ttg cgc aag ttc gtg ccc gag gac tac cat 25283 Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr His 4520 4525 4530 ccc ttc gag atc agg ttc tac gag gac caa tcc cag ccg cct aag 25328 Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys 4535 4540 4545 gcc gag ctg tcg gcc tgc gtc atc acc cag ggg gcc atc ctg gcc 25373 Ala Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala 4550 4555 4560 caa ttg caa gcc atc cag aaa tcc cgc caa gaa ttc ttg ctg aaa 25418 Gln Leu Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys 4565 4570 4575 aag ggc cgc ggg gtc tac ctc gac ccc cag acc ggt gag gag ctc 25463 Lys Gly Arg Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu 4580 4585 4590 aac ccc ggc ttc ccc cag gat gcc ccg agg aaa caa gaa gct gaa 25508 Asn Pro Gly Phe Pro Gln Asp Ala Pro Arg Lys Gln Glu Ala Glu 4595 4600 4605 agt gga gct gcc gcc cgt gga gga ttt gga gga aga ctg gga gaa 25553 Ser Gly Ala Ala Ala Arg Gly Gly Phe Gly Gly Arg Leu Gly Glu 4610 4615 4620 cag cag tca ggc aga gga gga gat gga gga aga ctg gga cag cac 25598 Gln Gln Ser Gly Arg Gly Gly Asp Gly Gly Arg Leu Gly Gln His 4625 4630 4635 tca ggc aga gga gga cag cct gca aga cag tct gga gga aga cga 25643 Ser Gly Arg Gly Gly Gln Pro Ala Arg Gln Ser Gly Gly Arg Arg 4640 4645 4650 gga gga ggc aga ggt gga aga agc agc cgc cgc cag acc gtc gtc 25688 Gly Gly Gly Arg Gly Gly Arg Ser Ser Arg Arg Gln Thr Val Val 4655 4660 4665 ctc ggc ggg gga gaa agc aag cag cac gga tac cat ctc cgc tcc 25733 Leu Gly Gly Gly Glu Ser Lys Gln His Gly Tyr His Leu Arg Ser 4670 4675 4680 ggg tcg ggg tcc cgc tcg gcc cca cag tagatgggac gagaccgggc 25780 Gly Ser Gly Ser Arg Ser Ala Pro Gln 4685 4690 gattcccgaa ccccaccatc cagaccggta agaaggagcg gcagggatac aagtcctggc 25840 gggggcacaa aaacgccatc gtctcctgct tgcaggcctg cgggggcaac atctccttca 25900 ccaggcgcta cctgctcttc caccgcgggg tgaacttccc ccgcaacatc ttgcattact 25960 accgtcacct ccacagcccc tactacttcc aagaagaggc agcagcagaa aaagaccagc 26020 agaaaaccag cagctagaaa atccacagcg gcagcaggtg gactgaggat cgcggcgaac 26080 gagccggcgc agacccggga gctgaggaac cggatctttc ccaccctcta tgccatcttc 26140 cagcagagtc gggggcagga gcaggaactg aaagtcaaga accgttctct gcgctcgctc 26200 acccgcagtt gtctgtatca caagagcgaa gaccaacttc agcgcactct cgaggacgcc 26260 gaggctctct tcaacaagta ctgcgcgctc actcttaaag agtagcccgc gcccgcccag 26320 tcgcagaaaa aggcgggaat tacgtcacct gtgcccttcg ccctagccgc ctccacccat 26380 c atg agc aaa gag att ccc acg cct tac atg tgg agc tac cag ccc 26426 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro 4695 4700 4705 cag atg ggc ctg gcc gcc ggc gcc gcc cag gac tac tcc acc cgc 26471 Gln Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg 4710 4715 4720 atg aat tgg ctc agc gcc ggg ccc gcg atg atc tca cgg gtg aat 26516 Met Asn Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn 4725 4730 4735 gac atc cgc gcc cac cga aac cag ata ctc cta gaa cag tca gcg 26561 Asp Ile Arg Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala 4740 4745 4750 ctc acc gcc acg ccc cgc aat cac ctc aat ccg cgt aat tgg ccc 26606 Leu Thr Ala Thr Pro Arg Asn His Leu Asn Pro Arg Asn Trp Pro 4755 4760 4765 gcc gcc ctg gtg tac cag gaa att ccc cag ccc acg acc gta cta 26651 Ala Ala Leu Val Tyr Gln Glu Ile Pro Gln Pro Thr Thr Val Leu 4770 4775 4780 ctt ccg cga gac gcc cag gcc gaa gtc cag ctg act aac tca ggt 26696 Leu Pro Arg Asp Ala Gln Ala Glu Val Gln Leu Thr Asn Ser Gly 4785 4790 4795 gtc cag ctg gcg ggc ggc gcc acc ctg tgt cgt cac cgc ccc gct 26741 Val Gln Leu Ala Gly Gly Ala Thr Leu Cys Arg His Arg Pro Ala 4800 4805 4810 cag ggt ata aag cgg ctg gtg atc cgg ggc aga ggc aca cag ctc 26786 Gln Gly Ile Lys Arg Leu Val Ile Arg Gly Arg Gly Thr Gln Leu 4815 4820 4825 aac gac gag gtg gtg agc tct tcg ctg ggt ctg cga cct gac gga 26831 Asn Asp Glu Val Val Ser Ser Ser Leu Gly Leu Arg Pro Asp Gly 4830 4835 4840 gtc ttc caa atc gcc gga tcg ggg aga tct tcc ttc acg cct cgt 26876 Val Phe Gln Ile Ala Gly Ser Gly Arg Ser Ser Phe Thr Pro Arg 4845 4850 4855 cag gcg gtc ctg act ttg gag agt tcg tcc tcg cag ccc cgc tcg 26921 Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser Gln Pro Arg Ser 4860 4865 4870 ggc ggc atc ggc act ctc cag ttc gtg gag gag ttc act ccc tcg 26966 Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe Thr Pro Ser 4875 4880 4885 gtc tac ttc aac ccc ttc tcc ggc tcc ccc ggc cac tac ccg gac 27011 Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr Pro Asp 4890 4895 4900 gag ttc atc ccg aac ttt gac gcc atc agc gag tcg gtg gac ggc 27056 Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp Gly 4905 4910 4915 tac gat tga atg tcc cat ggt ggc gcg gct gac cta gct cgg ctt 27101 Tyr Asp Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu 4920 4925 4930 cga cac ctg gac cac tgc cgc cgc ttt cgc tgc ttc gct cgg gac 27146 Arg His Leu Asp His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp 4935 4940 4945 ctc gcc gag ttc acc tac ttc gag ctg ccc gag gag cat cct cag 27191 Leu Ala Glu Phe Thr Tyr Phe Glu Leu Pro Glu Glu His Pro Gln 4950 4955 4960 ggc ccg gcc cac gga gtg cgg atc gtc gtc gaa ggg ggc cta gac 27236 Gly Pro Ala His Gly Val Arg Ile Val Val Glu Gly Gly Leu Asp 4965 4970 4975 tcc cac ctg ctt cgg atc ttc agc cag cgc ccg atc ctg gtc gag 27281 Ser His Leu Leu Arg Ile Phe Ser Gln Arg Pro Ile Leu Val Glu 4980 4985 4990 cgc caa cag ggc aac acc ctc ctg acc ctc tac tgc atc tgc gac 27326 Arg Gln Gln Gly Asn Thr Leu Leu Thr Leu Tyr Cys Ile Cys Asp 4995 5000 5005 cac ccc ggc ctg cat gaa agt ctt tgt tgt ctg ctg tgt act gag 27371 His Pro Gly Leu His Glu Ser Leu Cys Cys Leu Leu Cys Thr Glu 5010 5015 5020 tat aat aaa agc tgagatcagc gactactccg gactcaactg tggtgtttct 27423 Tyr Asn Lys Ser gcatccatca accagtctct gaccttcacc gggaacgaga ccgagctcca gctccagtgt 27483 aagccccaca agaagtacct cacctggctg taccagggct ccccgatcgc cgttgttaac 27543 cactgcgacg acgacggagt cctgctgaac ggccccgcca accttacttt ttccacccgc 27603 agaagcaagc tactgctctt cagacccttc ctccccggga tctatcagtg catctcggga 27663 ccctgccatc acaccttcca cctgatcccg aataccacct cttccccagc accgctcccc 27723 actaacaacc aaactaacca ccaacgccac cgtcgagacc tttcctctga ttctaatacc 27783 actaccggag gtgagctccg aggtactaag aagtcctcac ctgggattta ttacggcccc 27843 tgggaggtgg tggggttaat agctttaggc ttagtagcgg gtgggctttt ggctctctgc 27903 tacctatacc tcccttgctg ttcctactta gtggtgcttt gttgctggtt taagaa 27959 atg ggg aag atc acc cta gtg tgc ggt gtg ctg gtg acg gtg gtg 28004 Met Gly Lys Ile Thr Leu Val Cys Gly Val Leu Val Thr Val Val 5025 5030 5035 ctt tcg att ctg gga ggg gga agc gcg gct gta gtg acg gag aag 28049 Leu Ser Ile Leu Gly Gly Gly Ser Ala Ala Val Val Thr Glu Lys 5040 5045 5050 aag gcc gat ccc tgc ttg act ttc aat ccc gat aaa tgc cgg ctg 28094 Lys Ala Asp Pro Cys Leu Thr Phe Asn Pro Asp Lys Cys Arg Leu 5055 5060 5065 agt ttt cag cca gat ggc aat cgg tgc acg gtg ctg atc aag tgc 28139 Ser Phe Gln Pro Asp Gly Asn Arg Cys Thr Val Leu Ile Lys Cys 5070 5075 5080 gga tgg gaa tgc gag agc gtg gcg atc cag tat aaa aac aag acg 28184 Gly Trp Glu Cys Glu Ser Val Ala Ile Gln Tyr Lys Asn Lys Thr 5085 5090 5095 cgg aac aat act ctc gcg tcc aca tgg cag ccc ggg gac ccc gag 28229 Arg Asn Asn Thr Leu Ala Ser Thr Trp Gln Pro Gly Asp Pro Glu 5100 5105 5110 tgg tac acc gtc tct gtc cct ggt gct gac ggc tcc ctc cac acg 28274 Trp Tyr Thr Val Ser Val Pro Gly Ala Asp Gly Ser Leu His Thr 5115 5120 5125 gtg aac aac act ttc att ttt gag cac atg tgc gaa acc gcc atg 28319 Val Asn Asn Thr Phe Ile Phe Glu His Met Cys Glu Thr Ala Met 5130 5135 5140 ttc atg agc aag cag tac ggt atg tgg ccc cca cga aaa gag aat 28364 Phe Met Ser Lys Gln Tyr Gly Met Trp Pro Pro Arg Lys Glu Asn 5145 5150 5155 atc gtg gtc ttc tcc atc gct tac agc gcg tgc acg gtg cta atc 28409 Ile Val Val Phe Ser Ile Ala Tyr Ser Ala Cys Thr Val Leu Ile 5160 5165 5170 acc gcg atc gtg tgc ctg agc att cac atg ctc atc gct att cgc 28454 Thr Ala Ile Val Cys Leu Ser Ile His Met Leu Ile Ala Ile Arg 5175 5180 5185 ccc aga aat aat gcc gag aaa gag aaa cag cca taacacactt 28497 Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 5190 5195 5200 ttttcacaca ccttgttttt tacagaca atg cgt ctg tta att ttt gtt atc 28549 Met Arg Leu Leu Ile Phe Val Ile 5205 att aca ctc agc ttt aac tat gcc cat ggc tat gca aat ata caa 28594 Ile Thr Leu Ser Phe Asn Tyr Ala His Gly Tyr Ala Asn Ile Gln 5210 5215 5220 aaa acc ctc tat gta ggc tct gac tct aca tta gaa ggt act caa 28639 Lys Thr Leu Tyr Val Gly Ser Asp Ser Thr Leu Glu Gly Thr Gln 5225 5230 5235 tct caa gcc agg gtt tca tgg tat ttt tat aaa ggc tct gat gac 28684 Ser Gln Ala Arg Val Ser Trp Tyr Phe Tyr Lys Gly Ser Asp Asp 5240 5245 5250 cca att act ctt tgc aaa ggt gat cag ggg cgc ata aca aag cca 28729 Pro Ile Thr Leu Cys Lys Gly Asp Gln Gly Arg Ile Thr Lys Pro 5255 5260 5265 cct atc aca ttt agc tgc acc aga aca aac ctc acg ctt tta tcc 28774 Pro Ile Thr Phe Ser Cys Thr Arg Thr Asn Leu Thr Leu Leu Ser 5270 5275 5280 att aca aaa gaa tat gct ggc act tat tac agc aca aat ttt cat 28819 Ile Thr Lys Glu Tyr Ala Gly Thr Tyr Tyr Ser Thr Asn Phe His 5285 5290 5295 cgt ggg caa gat aaa tat tat act gtt aag gta gaa aac cct acc 28864 Arg Gly Gln Asp Lys Tyr Tyr Thr Val Lys Val Glu Asn Pro Thr 5300 5305 5310 acc cct aga aca act aca aag ccc acc aca act aag aag ccc act 28909 Thr Pro Arg Thr Thr Thr Lys Pro Thr Thr Thr Lys Lys Pro Thr 5315 5320 5325 aca cct aag aag cct acc aca ccc aaa acc act aag aca aca act 28954 Thr Pro Lys Lys Pro Thr Thr Pro Lys Thr Thr Lys Thr Thr Thr 5330 5335 5340 gct aag acc act acc aca aag cca acc aca acc agc acc aca ctt 28999 Ala Lys Thr Thr Thr Thr Lys Pro Thr Thr Thr Ser Thr Thr Leu 5345 5350 5355 gct ata act aca cac aca cac act gag ctg acc tca cag gca act 29044 Ala Ile Thr Thr His Thr His Thr Glu Leu Thr Ser Gln Ala Thr 5360 5365 5370 act gaa aat gat ttg gtt gcc ctg ttg caa aag ggg gag aac agt 29089 Thr Glu Asn Asp Leu Val Ala Leu Leu Gln Lys Gly Glu Asn Ser 5375 5380 5385 agc agc agt cct ctg cct act acc ccc agt gag gaa ata ccc aag 29134 Ser Ser Ser Pro Leu Pro Thr Thr Pro Ser Glu Glu Ile Pro Lys 5390 5395 5400 tcc atg gtt ggc att atc gct gct gta gtg gtg tgt atg ctg att 29179 Ser Met Val Gly Ile Ile Ala Ala Val Val Val Cys Met Leu Ile 5405 5410 5415 atc atc ttg tgc atg atg tac tat gcc tgc tac tac aga aaa cac 29224 Ile Ile Leu Cys Met Met Tyr Tyr Ala Cys Tyr Tyr Arg Lys His 5420 5425 5430 agg ctg aac aac aaa ctg gac ccc tta ctg agt gtt gat ttt 29266 Arg Leu Asn Asn Lys Leu Asp Pro Leu Leu Ser Val Asp Phe 5435 5440 5445 taatttttta gaaccatgaa gatcctaagc ctttttgttt tttctataat tattacctct 29326 gctatttgtg aatcagtgga taaggacgtt actgtcacca ctggctctaa ttatacacta 29386 aaagggcctt cctcaggtat gctttcgtgg tattgttatt ttggaaatga tgataaacag 29446 acagagctat gtaactttca gaacggcaaa accaaaaatt ctaaaataga taactatcaa 29506 tgccagggta ctaatttagt actgatgaat atcacgaaag catatgctgg cagttattcc 29566 tgtcctggac aaaacaccga ggaaatgatt ttttacaaat taattgtagt tgaccctact 29626 actccagcac cacccaccac aaccaaggca cataccacag acacacagga aaccactcca 29686 gaggcagaag tagcagagtt agcaaagcag attcatgaag attcatttgt tgccaatacc 29746 cccacacacc ccggaccgca atgtccaggg ccattagtca gcggcattgt cggtgtgctt 29806 tgcgggttag cagttataat catctgcatg ttcatttttg cttgctgcta cagaaggctt 29866 caccgacaaa aatcagaccc actgctgaac ctctatgttt aatttttgat tttccagagc 29926 c atg aag gca ctt agc act tta gta ttt ttg tcc ttg att ggc att 29972 Met Lys Ala Leu Ser Thr Leu Val Phe Leu Ser Leu Ile Gly Ile 5450 5455 5460 gtt ttc agt gct ggg ttt ttg aaa aat ctt acc att att gaa ggt 30017 Val Phe Ser Ala Gly Phe Leu Lys Asn Leu Thr Ile Ile Glu Gly 5465 5470 5475 gat aat gca aca ctg gta gga atc agc ggt cag aat gtt agt tgg 30062 Asp Asn Ala Thr Leu Val Gly Ile Ser Gly Gln Asn Val Ser Trp 5480 5485 5490 cta aaa tat cat cta gat ggg tgg aaa cct att tgc acc tgg aat 30107 Leu Lys Tyr His Leu Asp Gly Trp Lys Pro Ile Cys Thr Trp Asn 5495 5500 5505 gtc agt gtg tac aca tgc cat ggt gtt aac ctc acc att acc aat 30152 Val Ser Val Tyr Thr Cys His Gly Val Asn Leu Thr Ile Thr Asn 5510 5515 5520 gcc acc caa gat cag aat ggc agg ttt aag ggt cag agt ttc act 30197 Ala Thr Gln Asp Gln Asn Gly Arg Phe Lys Gly Gln Ser Phe Thr 5525 5530 5535 agc aac aat ggg tat gaa acc cat aac atg ttc atc tat gat gtc 30242 Ser Asn Asn Gly Tyr Glu Thr His Asn Met Phe Ile Tyr Asp Val 5540 5545 5550 act gtc ata tca aat aag act aca cct acc aca cag aca ccc act 30287 Thr Val Ile Ser Asn Lys Thr Thr Pro Thr Thr Gln Thr Pro Thr 5555 5560 5565 aca cat agc tca act cat gcc atg cag acc act cag aca acc aca 30332 Thr His Ser Ser Thr His Ala Met Gln Thr Thr Gln Thr Thr Thr 5570 5575 5580 tac act aca tct act gag tcc acc acc acc act aca gca gag gta 30377 Tyr Thr Thr Ser Thr Glu Ser Thr Thr Thr Thr Thr Ala Glu Val 5585 5590 5595 tcc agc aca gcg cct cag ccc cag gca ttg gct ttg atg gct cag 30422 Ser Ser Thr Ala Pro Gln Pro Gln Ala Leu Ala Leu Met Ala Gln 5600 5605 5610 cct agc agc atg act gct aaa acc aat gag cag act act gaa ttt 30467 Pro Ser Ser Met Thr Ala Lys Thr Asn Glu Gln Thr Thr Glu Phe 5615 5620 5625 ttg tcc act att cag agc agc acc aca gct acc tcg agt gcc ttc 30512 Leu Ser Thr Ile Gln Ser Ser Thr Thr Ala Thr Ser Ser Ala Phe 5630 5635 5640 tct agc acc gcc aat ctc acc tcg ctt tcc tct acg cca atc agt 30557 Ser Ser Thr Ala Asn Leu Thr Ser Leu Ser Ser Thr Pro Ile Ser 5645 5650 5655 aac gct act acc tcc ccc gct cct ctt ccc act cct ctg aag caa 30602 Asn Ala Thr Thr Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys Gln 5660 5665 5670 tcc gag tct agc acg cag ctg cag atc acc ctg ctc att gtg atc 30647 Ser Glu Ser Ser Thr Gln Leu Gln Ile Thr Leu Leu Ile Val Ile 5675 5680 5685 ggg gtg gtc atc ctg gca gtg ctg ctc tac ttt atc ttc tgc cgc 30692 Gly Val Val Ile Leu Ala Val Leu Leu Tyr Phe Ile Phe Cys Arg 5690 5695 5700 cgc atc ccc aac gcg aaa ccg gcc tac aag ccc att gtt atc ggg 30737 Arg Ile Pro Asn Ala Lys Pro Ala Tyr Lys Pro Ile Val Ile Gly 5705 5710 5715 acg ccg gag ccg ctt cag gtg gag gga ggt cta agg aat ctt ctc 30782 Thr Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu 5720 5725 5730 ttc tct ttt aca gta tgg tgatttgaac tatgattcct agacatttca 30830 Phe Ser Phe Thr Val Trp 5735 ttatcacttc tctaatctgt gtgctccaag tctgtgccac cctcgctctc gtggctaacg 30890 cgagtccaga ctgcattgga gcgttcgcct cctacgtgct ctttgccttc atcacctgca 30950 tctgctgctg tagcatagtc tgcctgctta tcaccttctt ccagttcgtt gactgggtct 31010 ttgtgcgcat cgcctacctg cgccaccacc cccagtaccg cgaccagaga gtggcgcaac 31070 tgttgagact catctg atg ata agc atg cgg gct ctg cta cta ctt ctc 31119 Met Ile Ser Met Arg Ala Leu Leu Leu Leu Leu 5740 5745 gcg ctt ctg cta gct ccc ctc gcc gcc ccc cta tcc ctc aaa tcc 31164 Ala Leu Leu Leu Ala Pro Leu Ala Ala Pro Leu Ser Leu Lys Ser 5750 5755 5760 ccc acc cag tcc cct gaa gag gtt cga aaa tgt aaa ttc caa gaa 31209 Pro Thr Gln Ser Pro Glu Glu Val Arg Lys Cys Lys Phe Gln Glu 5765 5770 5775 ccc tgg aaa ttc ctt tca tgc tac aaa ctc aaa tca gaa atg cac 31254 Pro Trp Lys Phe Leu Ser Cys Tyr Lys Leu Lys Ser Glu Met His 5780 5785 5790 ccc agc tgg atc atg atc gtt gga atc gta aac atc ctt gcc tgt 31299 Pro Ser Trp Ile Met Ile Val Gly Ile Val Asn Ile Leu Ala Cys 5795 5800 5805 acc ctc ttc tcc ttt gtg att tac ccc cgc ttt gac ttt ggg tgg 31344 Thr Leu Phe Ser Phe Val Ile Tyr Pro Arg Phe Asp Phe Gly Trp 5810 5815 5820 aac gca ccc gag gcg ctc tgg ctc ccg cct gat ccc gac aca cca 31389 Asn Ala Pro Glu Ala Leu Trp Leu Pro Pro Asp Pro Asp Thr Pro 5825 5830 5835 cca cag cag cag caa aat cag gca cag gca cat gca cca cca cag 31434 Pro Gln Gln Gln Gln Asn Gln Ala Gln Ala His Ala Pro Pro Gln 5840 5845 5850 cct agg cca caa tac atg ccc atc tta gac tat gag gcc gag cca 31479 Pro Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro 5855 5860 5865 cag cga gcc atg ctt cct gct att agt tac ttc aat cta acc ggc 31524 Gln Arg Ala Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly 5870 5875 5880 gga gat gac tgaccccatg gccaacaaca ccgtcaacga cctcctggac 31573 Gly Asp Asp 5885 atggacggcc gcgcctcgga gcagcgactc gcccaactcc gcatccgcca gcagcaggag 31633 agagccgtca aggagctgca ggacgcggtg gccatccacc agtgcaagag aggcatcttc 31693 tgcctggtga agcaggccaa gatctccttc gaggtcacgt ccaccgacca tcgcctctcc 31753 tacgagctcc tgcagcagcg ccagaagttc acctgcctgg tcggagtcaa ccccatcgtc 31813 atcacccagc agtctggcga taccaagggt tgcatccact gctcctgcga ctcccccgag 31873 tgcgttcaca ccctgatcaa gaccctctgc ggcctccgcg acctcctccc catgaactaa 31933 tcaactaacc ccctacccct ttaccctcca gtaaaaataa agattaaaaa tgattgaatt 31993 gatcaataaa gaatcactta cttgaaatct gaaaccaggt ctctgtcc atg ttt tct 32050 Met Phe Ser 5890 gtc agc agc act tca ctc ccc tct tcc caa ctc tgg tac tgc agg 32095 Val Ser Ser Thr Ser Leu Pro Ser Ser Gln Leu Trp Tyr Cys Arg 5895 5900 5905 ccc cgg cgg gct gca aac ttc ctc cac act ctg aag ggg atg tca 32140 Pro Arg Arg Ala Ala Asn Phe Leu His Thr Leu Lys Gly Met Ser 5910 5915 5920 aat tcc tcc tgt ccc tca atc ttc att ttt atc ttc tat cag atg 32185 Asn Ser Ser Cys Pro Ser Ile Phe Ile Phe Ile Phe Tyr Gln Met 5925 5930 5935 tcc aaa aag cgc gcg cgg gtg gat gat ggc ttc gac ccc gtg tac 32230 Ser Lys Lys Arg Ala Arg Val Asp Asp Gly Phe Asp Pro Val Tyr 5940 5945 5950 ccc tac gat gca gac aac gca ccg act gtg ccc ttc atc aac cct 32275 Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro 5955 5960 5965 ccc ttc gtc tct tca gat gga ttc caa gaa aag ccc ctg ggg gtg 32320 Pro Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val 5970 5975 5980 ttg tcc ctg cga ctg gcc gac ccc gtc acc acc aag aat ggg gct 32365 Leu Ser Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Ala 5985 5990 5995 gtc acc ctc aag ctg ggg gag ggg gtg gac ctc gac gac tcg gga 32410 Val Thr Leu Lys Leu Gly Glu Gly Val Asp Leu Asp Asp Ser Gly 6000 6005 6010 aaa ctc atc tcc aaa aat gcc acc aag gcc act gcc cct ctc agt 32455 Lys Leu Ile Ser Lys Asn Ala Thr Lys Ala Thr Ala Pro Leu Ser 6015 6020 6025 att tcc aac ggc acc att tcc ctt aac atg gcc gcc cct ttt tac 32500 Ile Ser Asn Gly Thr Ile Ser Leu Asn Met Ala Ala Pro Phe Tyr 6030 6035 6040 aac aac aat gga acg tta agt ctc aat gtt tct aca cca tta gca 32545 Asn Asn Asn Gly Thr Leu Ser Leu Asn Val Ser Thr Pro Leu Ala 6045 6050 6055 gta ttt ccc act ttt aac act tta ggt atc agt ctt gga aac ggt 32590 Val Phe Pro Thr Phe Asn Thr Leu Gly Ile Ser Leu Gly Asn Gly 6060 6065 6070 ctt caa act tct aat aag ttg ctg act gta cag tta act cat cct 32635 Leu Gln Thr Ser Asn Lys Leu Leu Thr Val Gln Leu Thr His Pro 6075 6080 6085 ctt aca ttc agc tca aat agc atc aca gta aaa aca gac aaa gga 32680 Leu Thr Phe Ser Ser Asn Ser Ile Thr Val Lys Thr Asp Lys Gly 6090 6095 6100 ctc tat att aat tct agt gga aac aga ggg ctt gag gct aac ata 32725 Leu Tyr Ile Asn Ser Ser Gly Asn Arg Gly Leu Glu Ala Asn Ile 6105 6110 6115 agc cta aaa aga gga ctg att ttt gat ggt aat gct att gca aca 32770 Ser Leu Lys Arg Gly Leu Ile Phe Asp Gly Asn Ala Ile Ala Thr 6120 6125 6130 tac ctt gga agt ggt tta gac tat gga tcc tat gat agc gat ggg 32815 Tyr Leu Gly Ser Gly Leu Asp Tyr Gly Ser Tyr Asp Ser Asp Gly 6135 6140 6145 aaa aca aga ccc atc atc acc aaa att gga gca ggt ttg aat ttt 32860 Lys Thr Arg Pro Ile Ile Thr Lys Ile Gly Ala Gly Leu Asn Phe 6150 6155 6160 gat gct aat aat gcc atg gct gtg aag cta ggc aca ggt tta agt 32905 Asp Ala Asn Asn Ala Met Ala Val Lys Leu Gly Thr Gly Leu Ser 6165 6170 6175 ttt gac tct gcc ggt gcc tta aca gct gga aac aaa gag gat gac 32950 Phe Asp Ser Ala Gly Ala Leu Thr Ala Gly Asn Lys Glu Asp Asp 6180 6185 6190 aag cta aca ctt tgg act aca cct gac cca agc cct aat tgt caa 32995 Lys Leu Thr Leu Trp Thr Thr Pro Asp Pro Ser Pro Asn Cys Gln 6195 6200 6205 tta ctt tca gac aga gat gcc aaa ttt acc cta tgt ctt aca aaa 33040 Leu Leu Ser Asp Arg Asp Ala Lys Phe Thr Leu Cys Leu Thr Lys 6210 6215 6220 tgc ggt agt caa ata cta ggc act gtt gca gta gct gct gtt act 33085 Cys Gly Ser Gln Ile Leu Gly Thr Val Ala Val Ala Ala Val Thr 6225 6230 6235 gta ggt tca gca cta aat cca att aat gac aca gta aaa agc gcc 33130 Val Gly Ser Ala Leu Asn Pro Ile Asn Asp Thr Val Lys Ser Ala 6240 6245 6250 ata gta ttc ctt aga ttt gac tct gac ggt gtg ctc atg tca aac 33175 Ile Val Phe Leu Arg Phe Asp Ser Asp Gly Val Leu Met Ser Asn 6255 6260 6265 tca tca atg gta ggt gat tac tgg aac ttt agg gaa gga cag acc 33220 Ser Ser Met Val Gly Asp Tyr Trp Asn Phe Arg Glu Gly Gln Thr 6270 6275 6280 acc caa agt gtg gcc tat aca aat gct gtg gga ttc atg ccc aat 33265 Thr Gln Ser Val Ala Tyr Thr Asn Ala Val Gly Phe Met Pro Asn 6285 6290 6295 cta ggt gca tat cct aaa acc caa agc aaa aca cca aaa aat agt 33310 Leu Gly Ala Tyr Pro Lys Thr Gln Ser Lys Thr Pro Lys Asn Ser 6300 6305 6310 ata gta agt cag gta tat tta aat gga gaa act act atg cca atg 33355 Ile Val Ser Gln Val Tyr Leu Asn Gly Glu Thr Thr Met Pro Met 6315 6320 6325 aca ctg aca ata act ttc aat ggc act gat gaa aaa gac aca aca 33400 Thr Leu Thr Ile Thr Phe Asn Gly Thr Asp Glu Lys Asp Thr Thr 6330 6335 6340 cct gtg agc act tac tcc atg act ttt aca tgg cag tgg act gga 33445 Pro Val Ser Thr Tyr Ser Met Thr Phe Thr Trp Gln Trp Thr Gly 6345 6350 6355 gac tat aag gac aag aat att acc ttt gct acc aac tcc ttt act 33490 Asp Tyr Lys Asp Lys Asn Ile Thr Phe Ala Thr Asn Ser Phe Thr 6360 6365 6370 ttc tcc tac atg gcc caa gaa taaaccctgc atgccaaccc cattgttccc 33541 Phe Ser Tyr Met Ala Gln Glu 6375 accactatgg aaaactctga agcagaaaaa aataaagttc aagtgtttta ttgattcaac 33601 agttttcaca gaattcgagt agttattttc cctcctccct cccaactcat ggaatacacc 33661 accctctccc cacgcacagc cttaaacatc tgaatgccat tggtaatgga catggttttg 33721 gtctccacat tccacacagt ttcagagcga gccagtctcg ggtcggtcag ggagatgaaa 33781 ccctccgggc actcctgcat ctgcacctca aagttcagta gctgagggct gtcctcggtg 33841 gtcgggatca cagttatctg gaagaagagc ggtgagagtc ataatccgcg aacgggatcg 33901 ggcggttgtg gcgcatcagg ccccgcagca gtcgctgtct gcgccgctcc gtcaagctgc 33961 tgctcaaggg gtctgggtcc agggactccc tgcgcatgat gccgatggcc ctgagcatca 34021 gtcgcctggt gcggcgggcg cagcagcgga tgcggatctc actcaggtcg gagcagtacg 34081 tgcagcacag cactaccaag ttgttcaaca gtccatagtt caacgtgctc cagccaaaac 34141 tcatctgtgg aactatgctg cccacatgtc catcgtacca gatcctgatg taaatcaggt 34201 ggcgccccct ccagaacaca ctgcccatgt acatgatctc cttgggcatg tgcaggttca 34261 ccacctcccg gtaccacatc acccgctggt tgaacatgca gccctggata atcctgcgga 34321 accagatggc cagcaccgcc ccgcccgcca tgcagcgcag ggaccccggg tcctggcaat 34381 ggcagtggag cacccaccgc tcacggccgt ggattaactg ggagctgaac aagtctatgt 34441 tggcacagca caggcacacg ctcatgcatg tcttcagcac tctcagttcc tcgggggtca 34501 ggaccatgtc ccagggcacg gggaactctt gcaggacagt gaacccggca gaacagggca 34561 gccctcgcac acaacttaca ttgtgcatgg acagggtatc gcaatcaggc agcaccggat 34621 gatcctccac cagagaagcg cgggtctcgg tctcctcaca gcgaggtaag ggggccggcg 34681 gttggtacgg atgatggcgg gatgacgcta atcgtgttct ggatcgtgtc atgatggagc 34741 tgtttcctga cattttcgta cttcacgaag cagaacctgg tacgggcact gcacaccgct 34801 cgccggcgac ggtctcggcg cttcgagcgc tcggtgttga agttatagaa cagccactcc 34861 ctcagagcgt gcagtatctc ctgagcctct tgggtgatga aaatcccatc cgctctgatg 34921 gctctgatca catcggccac ggtggaatgg gccagaccca gccagatgat gcaattttgt 34981 tgggtttcgg tgacggaggg agagggaaga acaggaagaa ccatgattaa ctttattcca 35041 aacggtctcg gagcacttca aaatgcaggt cccggaggtg gcacctctcg cccccactgt 35101 gttggtggaa aataacagcc aggtcaaagg tgacacggtt ctcgagatgt tccacggtgg 35161 cttccagcaa agcctccacg cgcacatcca gaaacaagag gacagcgaaa gcgggagcgt 35221 tttctaattc ctcaatcatc atattacact cctgcaccat ccccagataa ttttcatttt 35281 tccagccttg aatgattcgt attagttcct gaggtaaatc caagccagcc atgataaaaa 35341 gctcgcgcag agcgccctcc accggcattc ttaagcacac cctcataatt ccaagagatt 35401 ctgctcctgg ttcacctgca gcagattaac aatgggaata tcaaaatctc tgccgcgatc 35461 cctaagctcc tccctcaaca ataactgtat gtaatctttc atatcatctc cgaaattttt 35521 agccataggg ccgccaggaa taagagcagg gcaagccaca ttacagataa agcgaagtcc 35581 tccccagtga gcattgccaa atgtaagatt gaaataagca tgctggctag accctgtgat 35641 atcttccaga taactggaca gaaaatcagg caagcaattt ttaagaaaat caacaaaaga 35701 aaagtcgtcc aggtgcaggt ttagagcctc aggaacaacg atggaataag tgcaaggagt 35761 gcgttccagc atggttagtg tttttttggt gatctgtaga acaaaaaata aacatgcaat 35821 attaaaccat gctagcctgg cgaacaggtg ggtaaatcac tctttccagc accaggcagg 35881 ctacggggtc tccggcgcga ccctcgtaga agctgtcgcc atgattgaaa agcatcaccg 35941 agagaccttc ccggtggccg gcatggatga ttcgagaaga agcatacact ccgggaacat 36001 tggcatccgt gagtgaaaaa aagcgaccta taaagcctcg gggcactaca atgctcaatc 36061 tcaattccag caaagccacc ccatgcggat ggagcacaaa attggcaggt gcgtaaaaaa 36121 tgtaattact cccctcctgc acaggcagca aagcccccgc tccctccaga aacacataca 36181 aagcctcagc gtccatagct taccgagcac ggcaggcgca agagtcagag aaaaggctga 36241 gctctaacct gactgcccgc tcctgtgctc aatatatagc cctaacctac actgacgtaa 36301 aggccaaagt ctaaaaatac ccgccaaaat gacacacacg cccagcacac gcccagaaac 36361 cggtgacaca ctcaaaaaaa tacgtgcgct tcctcaaacg cccaaaccgg cgtcatttcc 36421 gggttcccac gctacgtcac cgctcagcga ctttcaaatt ccgtcgaccg ttaaaaacgt 36481 cactcgcccc gcccctaacg gtcgcccttc tctcggccaa tcaccttcct cccttcccaa 36541 attcaaacgc ctcatttgca tattaacgcg cacaaaaagt ttgaggtata ttattgatga 36601 tgatcgttta aactatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca 36661 tcaggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc 36721 gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg 36781 caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt 36841 tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa 36901 gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct 36961 ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc 37021 cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg 37081 tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct 37141 tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag 37201 cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga 37261 agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga 37321 agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg 37381 gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag 37441 aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag 37501 ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat 37561 gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct 37621 taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac 37681 tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa 37741 tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg 37801 gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt 37861 gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca 37921 ttgctgcagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt 37981 cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct 38041 tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg 38101 cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg 38161 agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg 38221 cgtcaacacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa 38281 aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt 38341 aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt 38401 gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt 38461 gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca 38521 tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat 38581 ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca ttaacctata 38641 aaaataggcg tatcacgagg ccctttcgtc ttcaag 38677 <210> 176 <211> 363 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 176 Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 1 5 10 15 Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 20 25 30 His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 35 40 45 Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 50 55 60 Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 65 70 75 80 Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 85 90 95 Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 100 105 110 Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val 115 120 125 Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 130 135 140 Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 145 150 155 160 Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 165 170 175 Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 180 185 190 Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 195 200 205 Ala Ala Asp Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 210 215 220 Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 225 230 235 240 Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 245 250 255 Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 260 265 270 Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 275 280 285 Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 290 295 300 Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 305 310 315 320 Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 325 330 335 Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 340 345 350 Val Gly Gly Pro Gly His Lys Ala Arg Val Leu 355 360 <210> 177 <211> 394 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 177 Met His Pro Val Leu Arg Gln Met Arg Pro His His Pro Pro Pro Gln 1 5 10 15 Gln Gln Pro Pro Pro Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln 20 25 30 Gln Gln Leu Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala Gly 35 40 45 Gln Thr Ser Gln Tyr Asp Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala 50 55 60 Arg Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys 65 70 75 80 Arg Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp 85 90 95 Arg Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ala Arg Phe His Ala 100 105 110 Gly Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp 115 120 125 Glu Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala 130 135 140 His Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys 145 150 155 160 Glu Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu 165 170 175 Ile Ala Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu 180 185 190 Leu Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln 195 200 205 Leu Phe Leu Val Val Gln His Ser Arg Asp Asn Glu Ala Phe Arg Glu 210 215 220 Ala Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu 225 230 235 240 Val Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu 245 250 255 Ser Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys 260 265 270 Tyr Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys 275 280 285 Glu Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu 290 295 300 Thr Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg 305 310 315 320 Ala Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met 325 330 335 His Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser 340 345 350 Tyr Phe Asp Met Gly Ala Asp Leu His Trp Gln Pro Ser Arg Arg Ala 355 360 365 Leu Glu Ala Ala Gly Gly Pro Pro Tyr Ile Glu Glu Val Asp Asp Glu 370 375 380 Val Asp Glu Glu Gly Glu Tyr Leu Glu Asp 385 390 <210> 178 <211> 589 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 178 Met Gln Gln Gln Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu Gln 1 5 10 15 Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala Met 20 25 30 Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg Gln 35 40 45 Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val Pro 50 55 60 Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn Ala 65 70 75 80 Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val Tyr 85 90 95 Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val Gln 100 105 110 Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ala Gln 115 120 125 Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala Leu 130 135 140 Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln Glu 145 150 155 160 Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Thr Glu Val 165 170 175 Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr 180 185 190 Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys Asn 195 200 205 Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala Thr 210 215 220 Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu Val 225 230 235 240 Ala Pro Phe Thr Asp Ser Gly Ser Ile Asn Arg Asn Ser Tyr Leu Gly 245 250 255 Tyr Leu Ile Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp 260 265 270 Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly Gln 275 280 285 Asp Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr Asn 290 295 300 Arg Ser Gln Lys Ile Pro Pro Gln Tyr Thr Leu Ser Ala Glu Glu Glu 305 310 315 320 Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met Gln 325 330 335 Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn Met 340 345 350 Glu Pro Ser Met Tyr Ala Ser Asn Arg Pro Phe Ile Asn Lys Leu Met 355 360 365 Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr Asn 370 375 380 Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr Gly 385 390 395 400 Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp Val 405 410 415 Asp Ser Ser Val Phe Ser Pro Arg Pro Gly Ala Asn Glu Arg Pro Leu 420 425 430 Trp Lys Lys Glu Gly Ser Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly 435 440 445 Arg Glu Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro 450 455 460 Ser Leu Pro Phe Ser Leu Asn Ser Ile Arg Ser Ser Glu Leu Gly Arg 465 470 475 480 Ile Thr Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser 485 490 495 Leu Leu Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu 500 505 510 Ser Leu Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala Gln Glu His 515 520 525 Arg Asp Asp Pro Ser Gln Gly Ala Thr Ser Arg Gly Ser Ala Ala Arg 530 535 540 Lys Arg Arg Trp His Asp Arg Gln Arg Gly Leu Met Trp Asp Asp Glu 545 550 555 560 Asp Ser Ala Asp Asp Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Asn 565 570 575 Pro Phe Ala His Leu Arg Pro Arg Ile Gly Arg Met Met 580 585 <210> 179 <211> 532 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 179 Met Met Arg Arg Ala Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Met Ala Ala Ala Ala Ala Met Gln Pro Pro Leu 20 25 30 Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg 35 40 45 Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg 50 55 60 Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr 65 70 75 80 Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp 85 90 95 Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg 100 105 110 Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro 115 120 125 Asn Val Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met 130 135 140 Val Ser Arg Lys Thr Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln 145 150 155 160 Asp Ile Leu Glu Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn 165 170 175 Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp 180 185 190 Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile 195 200 205 Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val 210 215 220 Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro 225 230 235 240 Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg 245 250 255 Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly 260 265 270 Phe Gln Ile Met Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu 275 280 285 Leu Asp Val Asp Ala Tyr Glu Lys Ser Lys Glu Glu Ser Ala Ala Ala 290 295 300 Ala Thr Ala Ala Val Ala Thr Ala Ser Thr Glu Val Arg Gly Asp Asn 305 310 315 320 Phe Ala Ser Pro Ala Ala Val Ala Ala Ala Glu Ala Ala Glu Thr Glu 325 330 335 Ser Lys Ile Val Ile Gln Pro Val Glu Lys Asp Ser Lys Asp Arg Ser 340 345 350 Tyr Asn Val Leu Pro Asp Lys Ile Asn Thr Ala Tyr Arg Ser Trp Tyr 355 360 365 Leu Ala Tyr Asn Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr 370 375 380 Leu Leu Thr Thr Ser Asp Val Thr Cys Gly Val Glu Gln Val Tyr Trp 385 390 395 400 Ser Leu Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg 405 410 415 Gln Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val Tyr 420 425 430 Ser Lys Ser Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg 435 440 445 Ala Phe Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln 450 455 460 Ile Leu Val Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn 465 470 475 480 Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile 485 490 495 Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys 500 505 510 Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val Ala Pro Arg Val Leu Ser 515 520 525 Ser Arg Thr Phe 530 <210> 180 <211> 193 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 180 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Val Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ala 130 135 140 Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala Ala 145 150 155 160 Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val Arg 165 170 175 Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro Arg 180 185 190 Thr <210> 181 <211> 342 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 181 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Val Val Lys Glu Glu Arg Lys Pro Arg Lys 20 25 30 Ile Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Glu Ser Asp Val Asp 35 40 45 Gly Leu Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln 50 55 60 Trp Arg Gly Arg Lys Val Arg Pro Val Leu Arg Pro Gly Thr Thr Val 65 70 75 80 Val Phe Thr Pro Gly Glu Arg Ser Gly Thr Ala Ser Lys Arg Ser Tyr 85 90 95 Asp Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Ala Glu Arg 100 105 110 Leu Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Ser Ala Pro Lys Glu 115 120 125 Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu 130 135 140 Lys Pro Val Thr Leu Gln Gln Val Leu Pro Thr Ala Ala Pro Arg Arg 145 150 155 160 Gly Phe Lys Arg Glu Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met 165 170 175 Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu Thr Met Lys Val 180 185 190 Asp Pro Asp Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln Val 195 200 205 Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr Glu 210 215 220 Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr Met 225 230 235 240 Glu Val Gln Thr Asp Pro Trp Met Pro Ser Ala Thr Ser Arg Arg Pro 245 250 255 Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn Tyr Ala Leu 260 265 270 His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg Phe Tyr 275 280 285 Arg Gly His Thr Ser Arg Arg Arg Lys Thr Thr Thr Arg Arg Arg Arg 290 295 300 Arg Arg Thr Thr Ala Ala Ala Ser Thr Pro Ala Ala Leu Val Arg Arg 305 310 315 320 Val Tyr Arg Arg Gly Arg Ala Pro Leu Thr Leu Pro Arg Ala Arg Tyr 325 330 335 His Pro Ser Ile Ala Ile 340 <210> 182 <211> 77 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 182 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Ala Gly Asn Gly Met Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 183 <211> 259 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 183 Met Asp Ser Asp Ala Pro Gly Pro Val Met Cys Phe Arg Arg Gln Met 1 5 10 15 Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg Pro 20 25 30 Phe Met Gly Thr Trp Ser Asp Ile Gly Thr Ser Gln Leu Asn Gly Gly 35 40 45 Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser 50 55 60 Thr Leu Lys Thr Tyr Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly Gln 65 70 75 80 Ala Leu Arg Asp Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val Val 85 90 95 Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn Gln 100 105 110 Ala Val Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro Ala 115 120 125 Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu Asp 130 135 140 Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu Leu 145 150 155 160 Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu Gly 165 170 175 Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu Lys 180 185 190 Pro Glu Ser Ser Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Gln Pro 195 200 205 Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val Ala 210 215 220 Arg Ala Arg Pro Gly Gly Thr Ala Arg Pro His Ala Asn Trp Gln Ser 225 230 235 240 Thr Leu Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg Arg 245 250 255 Arg Cys Tyr <210> 184 <211> 931 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 184 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Thr Cys Gln Trp Thr Tyr Thr Asp Lys Gln Thr Glu Lys 130 135 140 Thr Ala Thr Tyr Gly Asn Ala Pro Val Gln Gly Ile Ala Ile Thr Lys 145 150 155 160 Asp Gly Ile Gln Leu Gly Thr Asp Ser Asp Gly Asn Pro Val Tyr Ala 165 170 175 Gln Lys Thr Phe Glu Pro Glu Pro Gln Val Gly Asp Ala Glu Trp His 180 185 190 Asp Thr Thr Gly Thr Asp Glu Lys Tyr Gly Gly Arg Ala Leu Lys Pro 195 200 205 Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys Pro Thr Asn 210 215 220 Lys Glu Gly Gly Gln Ala Lys Asn Arg Thr Lys Thr Asp Gly Thr Gly 225 230 235 240 Glu Glu Pro Asp Ile Asp Met Ala Phe Phe Asp Gly Arg Asn Ala Thr 245 250 255 Thr Ala Gly Leu Ala Pro Glu Ile Val Leu Tyr Thr Glu Asn Val Asp 260 265 270 Leu Glu Thr Pro Asp Thr His Ile Val Tyr Lys Ala Gly Thr Asp Asp 275 280 285 Ser Ser Ser Ser Ile Asn Leu Gly Gln Gln Ser Met Pro Asn Arg Pro 290 295 300 Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn 305 310 315 320 Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn 325 330 335 Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu 340 345 350 Leu Leu Asp Ser Leu Gly Asp Arg Thr Leu Tyr Phe Ser Met Trp Asn 355 360 365 Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His 370 375 380 Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asp Ala Val 385 390 395 400 Gly Arg Thr Asp Thr Tyr Gln Gly Ile Lys Pro Asn Gly Gly Asp Pro 405 410 415 Ala Thr Trp Ala Lys Asp Asp Ser Ala Asn Asp Ala Asn Glu Met Gly 420 425 430 Lys Gly Asn Pro Phe Ala Met Glu Ile Asn Ile Gln Ala Asn Leu Trp 435 440 445 Arg Asn Phe Leu Tyr Ala Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr 450 455 460 Lys Tyr Thr Pro Ala Asn Val Thr Leu Pro Thr Asn Thr Asn Thr Tyr 465 470 475 480 Asp Tyr Met Asn Gly Arg Val Val Ala Pro Ser Leu Val Asp Ser Tyr 485 490 495 Ile Asn Ile Gly Ala Arg Trp Ser Leu Asp Pro Met Asp Asn Val Asn 500 505 510 Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu 515 520 525 Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro Gln Lys 530 535 540 Phe Phe Ala Ile Lys Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr 545 550 555 560 Glu Trp Asn Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu 565 570 575 Gly Asn Asp Leu Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile 580 585 590 Asn Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr 595 600 605 Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp 610 615 620 Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr 625 630 635 640 Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly 645 650 655 Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser 660 665 670 Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp 675 680 685 Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe 690 695 700 Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn 705 710 715 720 Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn Val Ala 725 730 735 Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala His 740 745 750 Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys Asp 755 760 765 Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val 770 775 780 Val Asp Glu Val Asn Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr 785 790 795 800 Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg 805 810 815 Gln Gly Gln Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys 820 825 830 Ser Ala Val Thr Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val 835 840 845 Met Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu 850 855 860 Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu 865 870 875 880 Asp Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr 885 890 895 Val Val Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro His Arg 900 905 910 Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn 915 920 925 Ala Thr Thr 930 <210> 185 <211> 210 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 185 Met Met Ala Glu Ala Ala Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile 1 5 10 15 Ile Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys 20 25 30 Arg Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val 35 40 45 Asn Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala 50 55 60 Trp Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe 65 70 75 80 Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu 85 90 95 Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu 100 105 110 Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu 115 120 125 Phe Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro 130 135 140 Met Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly 145 150 155 160 Met Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu 165 170 175 Ala Leu Tyr Arg Phe Leu Asn Ser His Ser Ala Tyr Phe Arg Ser His 180 185 190 Arg Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Asn Gln 195 200 205 Asp Met 210 <210> 186 <211> 801 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 186 Met Glu Thr Gln Pro Ser Pro Thr Ser Pro Ser Ala Pro Thr Thr Ala 1 5 10 15 Asp Glu Lys Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro Pro Ser Pro 20 25 30 Ala Thr Ser Asp Ala Ala Ala Val Pro Asp Met Gln Glu Met Glu Glu 35 40 45 Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu Glu 50 55 60 Glu Leu Ala Val Arg Phe Gln Ser Ser Ser Gln Glu Asp Lys Glu Gln 65 70 75 80 Pro Glu Gln Glu Ala Glu Asn Glu Gln Ser Gln Ala Gly Leu Glu His 85 90 95 Asp Gly Asp Tyr Leu His Leu Ser Gly Glu Glu Asp Ala Leu Ile Lys 100 105 110 His Leu Ala Arg Gln Ala Ile Ile Val Lys Asp Ala Leu Leu Asp Arg 115 120 125 Thr Glu Val Pro Leu Ser Val Glu Glu Leu Ser Arg Ala Tyr Glu Leu 130 135 140 Asn Leu Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr 145 150 155 160 Cys Glu Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro 165 170 175 Glu Ala Leu Ala Thr Tyr His Ile Phe Phe Lys Asn Gln Lys Ile Pro 180 185 190 Val Ser Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Phe Asn Leu 195 200 205 Gly Pro Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro 210 215 220 Lys Ile Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala 225 230 235 240 Leu Gln Gly Glu Gly Gly Glu His Glu His His Ser Ala Leu Val Glu 245 250 255 Leu Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu 260 265 270 Leu Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met 275 280 285 Ser Ala Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Ile Ser 290 295 300 Glu Asp Glu Gly Met Gln Asp Ser Glu Asp Gly Lys Pro Val Val Ser 305 310 315 320 Asp Glu Gln Leu Ala Arg Trp Leu Gly Pro Asn Ala Ser Pro Gln Ser 325 330 335 Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr Val 340 345 350 Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu Arg 355 360 365 Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val Arg 370 375 380 Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr 385 390 395 400 Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr 405 410 415 Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr 420 425 430 Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln Gln 435 440 445 Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys 450 455 460 Asn Leu Lys Gly Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser 465 470 475 480 Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg 485 490 495 Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg 500 505 510 Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala 515 520 525 Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro 530 535 540 Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala Tyr 545 550 555 560 His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu Cys 565 570 575 His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys Asn 580 585 590 Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln 595 600 605 Gly Pro Ser Asp Asp Gly Glu Gly Ala Lys Gly Gly Leu Lys Leu Thr 610 615 620 Pro Gly Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp 625 630 635 640 Tyr His Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro 645 650 655 Lys Ala Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala 660 665 670 Gln Leu Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys 675 680 685 Gly Arg Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro 690 695 700 Gly Phe Pro Gln Asp Ala Pro Arg Lys Gln Glu Ala Glu Ser Gly Ala 705 710 715 720 Ala Ala Arg Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Gln Ser Gly 725 730 735 Arg Gly Gly Asp Gly Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly 740 745 750 Gln Pro Ala Arg Gln Ser Gly Gly Arg Arg Gly Gly Gly Arg Gly Gly 755 760 765 Arg Ser Ser Arg Arg Gln Thr Val Val Leu Gly Gly Gly Glu Ser Lys 770 775 780 Gln His Gly Tyr His Leu Arg Ser Gly Ser Gly Ser Arg Ser Ala Pro 785 790 795 800 Gln <210> 187 <211> 227 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 187 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Leu Thr Ala Thr 50 55 60 Pro Arg Asn His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Thr Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Ile Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 188 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 188 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Thr 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Val Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Gln Gln Gly Asn Thr Leu Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asp His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 189 <211> 176 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 189 Met Gly Lys Ile Thr Leu Val Cys Gly Val Leu Val Thr Val Val Leu 1 5 10 15 Ser Ile Leu Gly Gly Gly Ser Ala Ala Val Val Thr Glu Lys Lys Ala 20 25 30 Asp Pro Cys Leu Thr Phe Asn Pro Asp Lys Cys Arg Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Thr Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Ser Val Ala Ile Gln Tyr Lys Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Thr Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Leu His Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Glu His Met Cys Glu Thr Ala Met Phe Met Ser Lys Gln Tyr Gly Met 115 120 125 Trp Pro Pro Arg Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Ala Cys Thr Val Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 190 <211> 247 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 190 Met Arg Leu Leu Ile Phe Val Ile Ile Thr Leu Ser Phe Asn Tyr Ala 1 5 10 15 His Gly Tyr Ala Asn Ile Gln Lys Thr Leu Tyr Val Gly Ser Asp Ser 20 25 30 Thr Leu Glu Gly Thr Gln Ser Gln Ala Arg Val Ser Trp Tyr Phe Tyr 35 40 45 Lys Gly Ser Asp Asp Pro Ile Thr Leu Cys Lys Gly Asp Gln Gly Arg 50 55 60 Ile Thr Lys Pro Pro Ile Thr Phe Ser Cys Thr Arg Thr Asn Leu Thr 65 70 75 80 Leu Leu Ser Ile Thr Lys Glu Tyr Ala Gly Thr Tyr Tyr Ser Thr Asn 85 90 95 Phe His Arg Gly Gln Asp Lys Tyr Tyr Thr Val Lys Val Glu Asn Pro 100 105 110 Thr Thr Pro Arg Thr Thr Thr Lys Pro Thr Thr Thr Lys Lys Pro Thr 115 120 125 Thr Pro Lys Lys Pro Thr Thr Pro Lys Thr Thr Lys Thr Thr Thr Ala 130 135 140 Lys Thr Thr Thr Thr Lys Pro Thr Thr Thr Ser Thr Thr Leu Ala Ile 145 150 155 160 Thr Thr His Thr His Thr Glu Leu Thr Ser Gln Ala Thr Thr Glu Asn 165 170 175 Asp Leu Val Ala Leu Leu Gln Lys Gly Glu Asn Ser Ser Ser Ser Pro 180 185 190 Leu Pro Thr Thr Pro Ser Glu Glu Ile Pro Lys Ser Met Val Gly Ile 195 200 205 Ile Ala Ala Val Val Val Cys Met Leu Ile Ile Ile Leu Cys Met Met 210 215 220 Tyr Tyr Ala Cys Tyr Tyr Arg Lys His Arg Leu Asn Asn Lys Leu Asp 225 230 235 240 Pro Leu Leu Ser Val Asp Phe 245 <210> 191 <211> 291 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 191 Met Lys Ala Leu Ser Thr Leu Val Phe Leu Ser Leu Ile Gly Ile Val 1 5 10 15 Phe Ser Ala Gly Phe Leu Lys Asn Leu Thr Ile Ile Glu Gly Asp Asn 20 25 30 Ala Thr Leu Val Gly Ile Ser Gly Gln Asn Val Ser Trp Leu Lys Tyr 35 40 45 His Leu Asp Gly Trp Lys Pro Ile Cys Thr Trp Asn Val Ser Val Tyr 50 55 60 Thr Cys His Gly Val Asn Leu Thr Ile Thr Asn Ala Thr Gln Asp Gln 65 70 75 80 Asn Gly Arg Phe Lys Gly Gln Ser Phe Thr Ser Asn Asn Gly Tyr Glu 85 90 95 Thr His Asn Met Phe Ile Tyr Asp Val Thr Val Ile Ser Asn Lys Thr 100 105 110 Thr Pro Thr Thr Gln Thr Pro Thr Thr His Ser Ser Thr His Ala Met 115 120 125 Gln Thr Thr Gln Thr Thr Thr Tyr Thr Thr Ser Thr Glu Ser Thr Thr 130 135 140 Thr Thr Thr Ala Glu Val Ser Ser Thr Ala Pro Gln Pro Gln Ala Leu 145 150 155 160 Ala Leu Met Ala Gln Pro Ser Ser Met Thr Ala Lys Thr Asn Glu Gln 165 170 175 Thr Thr Glu Phe Leu Ser Thr Ile Gln Ser Ser Thr Thr Ala Thr Ser 180 185 190 Ser Ala Phe Ser Ser Thr Ala Asn Leu Thr Ser Leu Ser Ser Thr Pro 195 200 205 Ile Ser Asn Ala Thr Thr Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys 210 215 220 Gln Ser Glu Ser Ser Thr Gln Leu Gln Ile Thr Leu Leu Ile Val Ile 225 230 235 240 Gly Val Val Ile Leu Ala Val Leu Leu Tyr Phe Ile Phe Cys Arg Arg 245 250 255 Ile Pro Asn Ala Lys Pro Ala Tyr Lys Pro Ile Val Ile Gly Thr Pro 260 265 270 Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser Phe 275 280 285 Thr Val Trp 290 <210> 192 <211> 149 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 192 Met Ile Ser Met Arg Ala Leu Leu Leu Leu Leu Ala Leu Leu Leu Ala 1 5 10 15 Pro Leu Ala Ala Pro Leu Ser Leu Lys Ser Pro Thr Gln Ser Pro Glu 20 25 30 Glu Val Arg Lys Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Ser Cys 35 40 45 Tyr Lys Leu Lys Ser Glu Met His Pro Ser Trp Ile Met Ile Val Gly 50 55 60 Ile Val Asn Ile Leu Ala Cys Thr Leu Phe Ser Phe Val Ile Tyr Pro 65 70 75 80 Arg Phe Asp Phe Gly Trp Asn Ala Pro Glu Ala Leu Trp Leu Pro Pro 85 90 95 Asp Pro Asp Thr Pro Pro Gln Gln Gln Gln Asn Gln Ala Gln Ala His 100 105 110 Ala Pro Pro Gln Pro Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu 115 120 125 Ala Glu Pro Gln Arg Ala Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu 130 135 140 Thr Gly Gly Asp Asp 145 <210> 193 <211> 490 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 193 Met Phe Ser Val Ser Ser Thr Ser Leu Pro Ser Ser Gln Leu Trp Tyr 1 5 10 15 Cys Arg Pro Arg Arg Ala Ala Asn Phe Leu His Thr Leu Lys Gly Met 20 25 30 Ser Asn Ser Ser Cys Pro Ser Ile Phe Ile Phe Ile Phe Tyr Gln Met 35 40 45 Ser Lys Lys Arg Ala Arg Val Asp Asp Gly Phe Asp Pro Val Tyr Pro 50 55 60 Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro Phe 65 70 75 80 Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser Leu 85 90 95 Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Ala Val Thr Leu Lys 100 105 110 Leu Gly Glu Gly Val Asp Leu Asp Asp Ser Gly Lys Leu Ile Ser Lys 115 120 125 Asn Ala Thr Lys Ala Thr Ala Pro Leu Ser Ile Ser Asn Gly Thr Ile 130 135 140 Ser Leu Asn Met Ala Ala Pro Phe Tyr Asn Asn Asn Gly Thr Leu Ser 145 150 155 160 Leu Asn Val Ser Thr Pro Leu Ala Val Phe Pro Thr Phe Asn Thr Leu 165 170 175 Gly Ile Ser Leu Gly Asn Gly Leu Gln Thr Ser Asn Lys Leu Leu Thr 180 185 190 Val Gln Leu Thr His Pro Leu Thr Phe Ser Ser Asn Ser Ile Thr Val 195 200 205 Lys Thr Asp Lys Gly Leu Tyr Ile Asn Ser Ser Gly Asn Arg Gly Leu 210 215 220 Glu Ala Asn Ile Ser Leu Lys Arg Gly Leu Ile Phe Asp Gly Asn Ala 225 230 235 240 Ile Ala Thr Tyr Leu Gly Ser Gly Leu Asp Tyr Gly Ser Tyr Asp Ser 245 250 255 Asp Gly Lys Thr Arg Pro Ile Ile Thr Lys Ile Gly Ala Gly Leu Asn 260 265 270 Phe Asp Ala Asn Asn Ala Met Ala Val Lys Leu Gly Thr Gly Leu Ser 275 280 285 Phe Asp Ser Ala Gly Ala Leu Thr Ala Gly Asn Lys Glu Asp Asp Lys 290 295 300 Leu Thr Leu Trp Thr Thr Pro Asp Pro Ser Pro Asn Cys Gln Leu Leu 305 310 315 320 Ser Asp Arg Asp Ala Lys Phe Thr Leu Cys Leu Thr Lys Cys Gly Ser 325 330 335 Gln Ile Leu Gly Thr Val Ala Val Ala Ala Val Thr Val Gly Ser Ala 340 345 350 Leu Asn Pro Ile Asn Asp Thr Val Lys Ser Ala Ile Val Phe Leu Arg 355 360 365 Phe Asp Ser Asp Gly Val Leu Met Ser Asn Ser Ser Met Val Gly Asp 370 375 380 Tyr Trp Asn Phe Arg Glu Gly Gln Thr Thr Gln Ser Val Ala Tyr Thr 385 390 395 400 Asn Ala Val Gly Phe Met Pro Asn Leu Gly Ala Tyr Pro Lys Thr Gln 405 410 415 Ser Lys Thr Pro Lys Asn Ser Ile Val Ser Gln Val Tyr Leu Asn Gly 420 425 430 Glu Thr Thr Met Pro Met Thr Leu Thr Ile Thr Phe Asn Gly Thr Asp 435 440 445 Glu Lys Asp Thr Thr Pro Val Ser Thr Tyr Ser Met Thr Phe Thr Trp 450 455 460 Gln Trp Thr Gly Asp Tyr Lys Asp Lys Asn Ile Thr Phe Ala Thr Asn 465 470 475 480 Ser Phe Thr Phe Ser Tyr Met Ala Gln Glu 485 490 <210> 194 <211> 31980 <212> DNA <213> Artificial Sequence <220> <223> Simian adenovirus A1337 clone <220> <221> CDS <222> (25483)..(26034) <223> 22K <220> <221> CDS <222> (27340)..(27975) <223> E3\CR1-alpha <220> <221> CDS <222> (31529)..(31930) <223> E3\14.7K <400> 194 aattgtttaa actaccatca tcaataatat acctcaaact ttttgtgcgc gttaatatgc 60 aaatgaggcg tttgaatttg ggaagggagg aaggtgattg gccgagagaa gggcgaccgt 120 taggggcggg gcgagtgacg ttttgatgac gtggccgcga ggaggagcca gtttgcaagt 180 tctcgtggga aaagtgacgt caaacgaggt gtggtttgaa cacggaaata ctcaattttc 240 ccgcgctctc tgacaggaaa tgaggtgttt ttgggcggat gcaagttaaa acgggccatt 300 ttcgcgcgaa aactgaatga ggaagtgaaa atctgagtaa tttcgcgttt atggcaggga 360 ggagtatttg ccgagggccg agtagacttt gaccgattac gtgggggttt cgattaccgt 420 gtttttcacc taaatttccg cgtacggtgt caaagtccgg tgtttttacg taactataac 480 ggtcctaagg tagcgaaagc tcagatctgg atctcccgat cccctatggc gactctcagt 540 acaatctgct ctgatgccgc atagttaagc cagtatctgc tccctgcttg tgtgttggag 600 gtcgctgagt agtgcgcgag caaaatttaa gctacaacaa ggcaaggctt gaccgacaat 660 tgcatgaaga atctgcttag ggttaggcgt tttgcgctgc ttcgcgatgt acgggccaga 720 tatacgcgtt gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta 780 gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc 840 tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg 900 ccaataggga ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg 960 gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa 1020 tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac 1080 atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg 1140 cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg 1200 agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca 1260 ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta 1320 gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac 1380 cgggaccgat ccagcctccg cgggcgcgcg tcgacagaga gatgggtgcg agagcgtcag 1440 tattaagcgg gggagaatta gatcgatggg aaaaaattcg gttaaggcca gggggaaaga 1500 agaagtacaa gctaaagcac atcgtatggg caagcaggga gctagaacga ttcgcagtta 1560 atcctggcct gttagaaaca tcagaaggct gtagacaaat actgggacag ctacaaccat 1620 cccttcagac aggatcagag gagcttcgat cactatacaa cacagtagca accctctatt 1680 gtgtgcacca gcggatcgag atcaaggaca ccaaggaagc tttagacaag atagaggaag 1740 agcaaaacaa gtccaagaag aaggcccagc aggcagcagc tgacacagga cacagcaatc 1800 aggtcagcca aaattaccct atagtgcaga acatccaggg gcaaatggta catcaggcca 1860 tatcacctag aactttaaat gcatgggtaa aagtagtaga agagaaggct ttcagcccag 1920 aagtgatacc catgttttca gcattatcag aaggagccac cccacaggac ctgaacacga 1980 tgttgaacac cgtgggggga catcaagcag ccatgcaaat gttaaaagag accatcaatg 2040 aggaagctgc agattgggat agagtgcatc cagtgcatgc agggcctatt gcaccaggcc 2100 agatgagaga accaagggga agtgacatag caggaactac tagtaccctt caggaacaaa 2160 taggatggat gacaaataat ccacctatcc cagtaggaga gatctacaag aggtggataa 2220 tcctgggatt gaacaagatc gtgaggatgt atagccctac cagcattctg gacataagac 2280 aaggaccaaa ggaacccttt agagactatg tagaccggtt ctataaaact ctaagagctg 2340 agcaagcttc acaggaggta aaaaattgga tgacagaaac cttgttggtc caaaatgcga 2400 acccagattg taagaccatc ctgaaggctc tcggcccagc ggctacacta gaagaaatga 2460 tgacagcatg tcagggagta ggaggacccg gccataaggc aagagttttg tagggatcca 2520 ctagttctag actcgagggg gggcccggta cctttaagac caatgactta caaggcagct 2580 gtagatctta gccacttttt aaaagaaaag gggggactgg aagggctaat tcactcccaa 2640 agaagacaag ataaaccgct gatcagcctc gactgtgcct tctagttgcc agccatctgt 2700 tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc 2760 ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg 2820 tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga 2880 tgcggtgggc tctatggctt ctgaggcgga aagaaccagc agatctgcag atctgaattc 2940 atctatgtcg ggtgcggaga aagaggtaat gaaatggcac atatgctggc caccgtgcat 3000 gtggcttccc atgcccgcaa gccctggccc gagttcgagc acaatgtcat gaccaggtgc 3060 aatatgcatc tggggtctcg ccgaggcatg ttcatgccct accagtgcaa cctgaattat 3120 gtgaaggtgc tgctggagcc cgatgccatg tccagagtga gcctgacggg ggtgtttgac 3180 atgaatgtgg aggtgtggaa gattctgaga tatgatgaat ccaagaccag gtgccgagcc 3240 tgcgagtgcg gagggaagca tgccaggttc cagcccgtgt gtgtggatgt gacggaggac 3300 ctgcgacccg atcatttggt gttgtcctgc accgggacgg agttcggttc cagcggggaa 3360 gaatctgact agagtgagta gtgttctggg gcgggggagg acctgcatga gggccagaat 3420 gattgaaatc tgtgcttttc tgtgtgttgc agcagcatga gcggaagcgg ctcctttgag 3480 ggaggggtat tcagccctta tctgacgggg cgtctcccct cctgggcggg agtgcgtcag 3540 aatgtgatgg gatccacggt ggacggccgg cccgtgcagc ccgcgaactc ttcaaccctg 3600 acctatgcaa ccctgagctc ttcgtcggtg gacgcagctg ccgccgcagc tgctgcatct 3660 gccgccagcg ccgtgcgcgg aatggccatg ggcgccggct actacggcac tctggtggcc 3720 aactcgagtt ccaccaataa tcccgccagc ctgaacgagg agaagctgct gctgctgatg 3780 gcccagctcg aggccttgac ccagcgcctg ggcgagctga cccagcaggt ggctcagctg 3840 caggagcaga cgcgggccgc ggttgccacg gtgaaatcca aataaaaaat gaatcaataa 3900 ataaacggag acggttgttg attttaacac agagtctgaa tctttatttg atttttcgcg 3960 cgcggtaggc cctggaccac cggtctcgat cattgagcac tcggtggatc ttttccagga 4020 cccggtagag gtgggcttgg atgttgaggt acatgggcat gagcccgtcc cgggggtgga 4080 ggtagctcca ttgcagggcc tcgtgctcgg gggtggtgtt gtaaatcacc cagtcatagc 4140 aggggcgcag ggcatggtgt tgcacaatat ctttgaggag gagactgatg gccacgggca 4200 gccctttggt gtaggtgttt acaaatctgt tgagctggga gggatgcatg cggggggaga 4260 tgaggtgcat cttggcctgg atcttgagat tggcgatgtt accgcccaga tcccgcctgg 4320 ggttcatgtt gtgcaggacc accagcacgg tgtatccggt gcacttgggg aatttatcat 4380 gcaacttgga agggaaggcg tgaaagaatt tggcgacgcc cttgtgcccg cccaggtttt 4440 ccatgcactc atccatgatg atggcgatgg ggccgtgggc ggcggcctgg gcaaaaacgt 4500 ttcgggggtc ggacacatca tagttgtggt cctgggtgag atcatcatag gccattttaa 4560 tgaatttggg gcggagggtg ccggactggg ggacaaaggt accctcgatc ccgggggcgt 4620 agttcccctc acagatctgc atctcccagg ctttgagctc ggaggggggg atcatgtcca 4680 cctgcggggc gataaagaac acggtttccg gggcgggaga gatgagctgg gccgaaagca 4740 agttccggag cagctgggac ttgccgcagc cggtggggcc gtagatgacc ccgatgaccg 4800 gttgcaggtg gtagttgagg gagagacagc tgccgtcctc ccggaggagg ggggccacct 4860 cgttcatcat ctcgcgcacg tgcatgttct cgcgcaccag ttccgccagg aggcgctctc 4920 cccccaggga taggagctcc tggagcgagg cgaagttttt cagcggcttg agtccgtcgg 4980 ccatgggcat tttggagagg gtctgttgca agagttccaa gcggtcccag agctcggtga 5040 tgtgctctac ggcatctcga tccagcagac ctcctcgttt cgcgggttgg ggcggctgcg 5100 ggagtagggc accagacgat gggcgtccag cgcagccagg gtccggtcct tccagggtcg 5160 cagcgtccgc gtcagggtgg tctccgtcac ggtgaagggg tgcgcgccgg gctgggcgct 5220 tgcgagggtg cgcttcaggc tcatccggct ggtcgaaaac cgctcccgat cggcgccctg 5280 cgcgtcggcc aggtagcaat tgaccatgag ttcgtaattg agcgcctcgg ccgcgtgacc 5340 tttggcgcgg agcttacctt tggaagtctg cccgcaggtg ggacagagga gggacttgag 5400 ggcgtagagc ttgggggcga ggaagacgga ctcgggggcg taggcgtccg cgccgcagtg 5460 ggcgcagacg gtctcgcact ccacgagcca ggtgaggtcg ggctggtcgg ggtcaaaaac 5520 cagtttcccg ccgttctttt tgatgcgttt cttacctttg gtctccatga gctcgtgtcc 5580 ccgctgggtg acaaagaggc tgtccgtgtc cccgtagacc gactttatgg gccggtcctc 5640 gagcggtgtg ccgcggtcct cctcgtagag gaaccccgcc cactccgaga cgaaagcccg 5700 ggtccaggcc agcacgaagg aggccacgtg ggacgggtag cggtcgttgt ccaccagcgg 5760 gtccaccttc tccagggtat gcaaacacat gtccccctcg tccacatcca ggaaggtgat 5820 tggcttgtaa gtgtaggcca cgtgaccggg ggtcccagcc gggggggtat aaaagggggc 5880 gggcccctgc tcgtcctcac tgtcttccgg atcgctgtcc aggagcgcca gctgttgggg 5940 taggtattcc ctctcgaagg cgggcatgac ctcggcactc aggttgtcag tttctagaaa 6000 cgaggaggat ttgatattga cggtgccggc ggagatgcct ttcaagagcc cctcgtccat 6060 ctggtcagaa aagacgatct ttttgttgtc gagtttggtg gcgaaggagc cgtagagggc 6120 attggagagg agcttggcga tagagcgcat ggtctggttt ttttccttgt cggcgcgctc 6180 cttggccgcg atgttgagct gcacgtactc gcgcgccacg cacttccatt cggggaagac 6240 ggtggtcagc tcgtcgggca cgattctgac ttgccagccc cggttatgca gggtgatgag 6300 gtccacactg gtgcccacct cgccgcgcag gggctcgttg gtccagcaga gtcgaccgcc 6360 cttgcgcgag cagaaggggg gcagggggtc cagcatgacc tcgtcggggg ggtcggcatc 6420 gatggtgaag atgcctggca ggagatcggg gtcgaagtag ctgatggaag tggccagatc 6480 gtccagggca gcttgccatt cgcgcacggc cagcgcgcgc tcgtagggac tgaggggcgt 6540 gccccaaggc atggggtgtg tgagcgcgga ggcgtacatg ccgcagatgt cgtagacgta 6600 gaggggctcc tcgaggatgc cgatgtaggt ggggtaacag cgccccccgc ggatgctggc 6660 gcgcacgtag tcatacagct catgcgaggg ggcgaggagc cccgggccca ggttggtgcg 6720 actgggcttt tcggcgcggt agacgatctg gcgaaagatg gcatgcgagt tggaggagat 6780 ggtgggcctt tggaagatgt tgaagtgggc gtggggcaga ccgaccgagt cgcggatgaa 6840 gtgggcgtag gagtcttgca gtttggcgac gagctcggcg gtgacgagga cgtccagagc 6900 gcagtagtcg agggtctcct ggatgatgtc atacttgagc tggccctttt gtttccacag 6960 ctcgcggttg agaaggaact cttcgcggtc cttccagtac tcttcgaggg ggaacccgtc 7020 ctgatctgca cggtaagagc ctagcatgta gaactggttg acggccttgt aggcgcagca 7080 gcccttctcc acggggaggg cgtaggcctg ggcggccttg cgcagggagg tgtgcgtgag 7140 ggcgaaggtg tccctgacca tgaccttgag gaactggtgc ttgaaatcga tatcgtcgca 7200 gcccccctgc tcccagagct ggaagtccgt gcgcttcttg taggcggggt tgggcaaagc 7260 gaaagtaaca tcgttgaaaa ggatcttgcc cgcgcggggc ataaagttgc gagtgatgcg 7320 gaaaggctgg ggcacctcgg cccggttgtt gatgacctgg gcggcgagca cgatctcgtc 7380 gaaaccgttg atgttgtggc ccacgatgta gagttccacg aatcgcgggc ggcccttgac 7440 gtggggcagc ttcttgagct cctcgtaggt gagctcgtcg gggtcgctga gaccgtgctg 7500 ctcgagcgcc cagtcggcga gatgggggtt ggcgcggagg aaggaagtcc agagatccac 7560 ggccagggcg gtttgcagac ggtcccggta ctgacggaac tgctgcccga cggccatttt 7620 ttcgggggtg acgcagtaga aggtgcgggg gtccccgtgc cagcggtccc atttgagctg 7680 gagggcgaga tcgagggcga gctcgacgag gcggtcgtcc ccggagagtt tcatgaccag 7740 catgaagggg acgagctgct tgccgaagga ccccatccag gtgtaggttt ccacatcgta 7800 ggtgaggaag agcctttcgg tgcgaggatg cgagccgatg gggaagaact ggatctcctg 7860 ccaccaattg gaggaatggc tgttgatgtg atggaagtag aaatgccgac ggcgcgccga 7920 acactcgtgc ttgtgtttat acaagcggcc acagtgctcg caacgctgca cgggatgcac 7980 gtgctgcacg agctgtacct gagttccttt gacgaggaat ttcagtggga agtggagtcg 8040 tggcgcctgc atctcgtgct gtactacgtc gtggtggtcg gcctggccct cttctgcctc 8100 gatggtggtc atgctgacga gcccgcgcgg gaggcaggtc cagacctcgg cgcgagcggg 8160 tcggagagcg aggacgaggg cgcgcaggcc ggagctgtcc agggtcctga gacgctgcgg 8220 agtcaggtca gtgggcagcg gcggcgcgcg gttgacttgc aggagttttt ccagggcgcg 8280 cgggaggtcc agatggtact tgatctccac cgcgccgttg gtggcgacgt cgatggcttg 8340 cagggtcccg tgcccctggg gtgtgaccac cgtcccccgt ttcttcttgg gcggctgggg 8400 cgacgggggc ggtgcctctt ccatggttag aagcggcggc gaggacgcgc gccgggcggc 8460 agaggcggct cggggcccgg aggcaggggc ggcaggggca cgtcggcgcc gcgcgcgggt 8520 aggttctggt actgcgcccg gagaagactg gcgtgagcga cgacgcgacg gttgacgtcc 8580 tggatctgac gcctctgggt gaaggccacg ggacccgtga gtttgaacct gaaagagagt 8640 tcgacagaat caatctcggt atcgttgacg gcggcctgcc gcaggatctc ttgcacgtcg 8700 cccgagttgt cctggtaggc gatctcggtc atgaactgct cgatctcctc ctcctgaagg 8760 tctccgcggc cggcgcgctc cacggtggcc gcgaggtcgt tggagatgcg gcccatgagc 8820 tgcgagaagg cgttcatgcc cgcctcgttc cagacgcggc tgtagaccac gacgccctcg 8880 ggatcgcggg cgcgcatgac cacctgggcg aggttgagct ccacgtggcg cgtgaagacc 8940 gcgtagttgc agaggcgctg gtagaggtag ttgagcgtgg tggcgatgtg ctcggtgacg 9000 aagaaataca tgatccagcg gcggagcggc atctcgctga cgtcgcccag cgcctccaag 9060 cgttccatgg cctcgtaaaa gtccacggcg aagttgaaaa actgggagtt gcgcgccgag 9120 acggtcaact cctcctccag aagacggatg agctcggcga tggtggcgcg cacctcgcgc 9180 tcgaaggccc ccgggagttc ctcctcttcc atctcctctt cttcctcctc cactaacatc 9240 tcttctactt cctcctcagg cggtggtggc gggggagggg gcctgcgtcg ccggcggcgc 9300 acgggcagac ggtcgatgaa gcgctcgatg gtctcgccgc gccggcgtcg catggtctcg 9360 gtgacggcgc gcccgtcctc gcggggccgc agcgtgaaga cgccgccgcg catctccagg 9420 tggccggggg ggtccccgtt gggcagggag agggcgctga cgatgcatct tatcaattgc 9480 cccgtaggga ctccgcgcaa ggacctgagc gtctcgagat ccacgggatc tgaaaaccgt 9540 tgaacgaagg cttcgagcca gtcgcagtcg caaggtaggc tgagcacggt ttcttctggc 9600 gggtcatgtt ggggagcggg gcgggcgatg ctgctggtga tgaagttgaa ataggcggtt 9660 ctgagacggc ggatggtggc gaggagcacc aggtctttgg gcccggcttg ctggatgcgc 9720 agacggtcgg ccatgcccca ggcgtggtcc tgacacctgg ccaggtcctt gtagtagtcc 9780 tgcatgagcc gctccacggg cacctcctcc tcgcccgcgc ggccgtgcat gcgcgtgagc 9840 ccgaagccgc gctggggctg gacgagcgcc aggtcggcga cgacgcgctc ggcgaggatg 9900 gcctgctgga tctgggtgag ggtggtctgg aagtcgtcaa agtcgacgaa gcggtggtag 9960 gctccggtgt tgatggtgta ggagcagttg gccatgacgg accagttgac ggtctggtgg 10020 cccggacgca cgagctcgtg gtacttgagg cgcgagtagg cgcgcgtgtc gaagatgtag 10080 tcgttgcagg tgcgcaccag gtactggtag ccgatgagga agtgcggcgg cggctggcgg 10140 tagagcggcc atcgctcggt ggcgggggcg ccgggcgcga ggtcctcgag catggtgcgg 10200 tggtagccgt agatgtacct ggacatccag gtgatgccgg cggcggtggt ggaggcgcgc 10260 gggaactcgc ggacgcggtt ccagatgttg cgcagcggca ggaagtagtt catggtgggc 10320 acggtctggc ccgtgaggcg cgcgcagtcg tggatgctct atacgggcaa aaacgaaagc 10380 ggtcagcggc tcgactccgt ggcctggagg ctaagcgaac gggttgggct gcgcgtgtac 10440 cccggttcga atctcgaatc aggctggagc cgcagctaac gtggtactgg cactcccgtc 10500 tcgacccaag cctgcaccaa ccctccagga tacggaggcg ggtcgttttg caactttttt 10560 tcggaggccg gaaatgaaga ctagtaagcg cggaaagcgg ccgaccgcga tggctcgctg 10620 ccgtagtctg gagaagaatc gccagggttg cgttgcggtg tgccccggtt cgaggccggc 10680 cggattccgc ggctaacgag ggcgtggctg ccccgtcgtt tccaagaccc cctagccagc 10740 cgacttctcc agttacggag cgagcccctc ttttgttttg tttgtttttg ccagatgcat 10800 cccgtactgc ggcagatgcg cccccaccac cctccaccgc aacaacagcc ccctccacag 10860 ccggcgcttc tgcccccgcc ccagcagcag cagcaacttc cagccacgac cgccgcggcc 10920 gccgtgagcg gggctggaca gacttctcag tatgacctgg ccttggaaga gggcgagggg 10980 ctggcgcgcc tgggggcgtc gtcgccggag cggcacccgc gcgtgcagat gaaaagggac 11040 gctcgcgagg cctacgtgcc caagcagaac ctgttcagag acaggagcgg cgaggagccc 11100 gaggagatgc gcgcggcccg gttccacgcg gggcgggagc tgcggcgcgg cctggaccga 11160 aagagggtgc tgagggacga ggatttcgag gcggacgagc tgacggggat cagccccgcg 11220 cgcgcgcacg tggccgcggc caacctggtc acggcgtacg agcagaccgt gaaggaggag 11280 agcaacttcc aaaaatcctt caacaaccac gtgcgcaccc tgatcgcgcg cgaggaggtg 11340 accctgggcc tgatgcacct gtgggacctg ctggaggcca tcgtgcagaa ccccaccagc 11400 aagccgctga cggcgcagct gttcctggtg gtgcagcata gtcgggacaa cgaggcgttc 11460 agggaggcgc tgctgaatat caccgagccc gagggccgct ggctcctgga cctggtgaac 11520 attctgcaga gcatcgtggt gcaggagcgc gggctgccgc tgtccgagaa gctggcggcc 11580 atcaacttct cggtgctgag tctgggcaag tactacgcta ggaagatcta caagaccccg 11640 tacgtgccca tagacaagga ggtgaagatc gacgggtttt acatgcgcat gaccctgaaa 11700 gtgctgaccc tgagcgacga tctgggggtg taccgcaacg acaggatgca ccgcgcggtg 11760 agcgccagca ggcggcgcga gctgagcgac caggagctga tgcatagtct gcagcgggcc 11820 ctgaccgggg ccgggaccga gggggagagc tactttgaca tgggcgcgga cctgcactgg 11880 cagcccagcc gccgggcctt ggaggcggca ggcggtcccc cctacataga agaggtggac 11940 gatgaggtgg acgaggaggg cgagtacctg gaagactgat ggcgcgaccg tatttttgct 12000 agatgcaaca acagccacct cctgatcccg cgatgcgggc ggcgctgcag agccagccgt 12060 ccggcattaa ctcctcggac gattggaccc aggccatgca acgcatcatg gcgctgacga 12120 cccgcaaccc cgaagccttt agacagcagc cccaggccaa ccggctctcg gccatcctgg 12180 aggccgtggt gccctcgcgc tccaacccca cgcacgagaa ggtcctggcc atcgtgaacg 12240 cgctggtgga gaacaaggcc atccgcggcg acgaggccgg cctggtgtac aacgcgctgc 12300 tggagcgcgt ggcccgctac aacagcacca acgtgcagac caacctggac cgcatggtga 12360 ccgacgtgcg cgaggccgtg gcccagcgcg agcggttcca ccgcgagtcc aacctgggat 12420 ccatggtggc gctgaacgcc ttcctcagca cccagcccgc caacgtgccc cggggccagg 12480 aggactacac caacttcatc agcgccctgc gcctgatggt gaccgaggtg ccccagagcg 12540 aggtgtacca gtccgggccg gactacttct tccagaccag tcgccagggc ttgcagaccg 12600 tgaacctgag ccaggcgttc aagaacttgc agggcctgtg gggcgtgcag gccccggtcg 12660 gggaccgcgc gacggtgtcg agcctgctga cgccgaactc gcgcctgctg ctgctgctgg 12720 tggccccctt cacggacagc ggcagcatca accgcaactc gtacctgggc tacctgatta 12780 acctgtaccg cgaggccatc ggccaggcgc acgtggacga gcagacctac caggagatca 12840 cccacgtgag ccgcgccctg ggccaggacg acccgggcaa tctggaagcc accctgaact 12900 ttttgctgac caaccggtcg cagaagatcc cgccccagta cacgctcagc gccgaggagg 12960 agcgcatcct gcgatacgtg cagcagagcg tgggcctgtt cctgatgcag gagggggcca 13020 cccccagcgc cgcgctcgac atgaccgcgc gcaacatgga gcccagcatg tacgccagca 13080 accgcccgtt catcaataaa ctgatggact acttgcatcg ggcggccgcc atgaactctg 13140 actatttcac caacgccatc ctgaatcccc actggctccc gccgccgggg ttctacacgg 13200 gcgagtacga catgcccgac cccaatgacg ggttcctgtg ggacgatgtg gacagcagcg 13260 tgttctcccc ccgaccgggt gctaacgagc gccccttgtg gaagaaggaa ggcagcgacc 13320 gacgcccgtc ctcggcgctg tccggccgcg agggtgctgc cgcggcggtg cccgaggccg 13380 ccagtccttt cccgagcttg cccttctcgc tgaacagtat tcgcagcagc gagctgggca 13440 ggatcacgcg cccgcgcttg ctgggcgagg aggagtactt gaatgactcg ctgttgagac 13500 ccgagcggga gaagaacttc cccaataacg ggatagagag cctggtggac aagatgagcc 13560 gctggaagac gtatgcgcag gagcacaggg acgatccgtc gcagggggcc acgagccggg 13620 gcagcgccgc ccgtaaacgc cggtggcacg acaggcagcg gggactgatg tgggacgatg 13680 aggattccgc cgacgacagc agcgtgttgg acttgggtgg gagtggtaac ccgttcgctc 13740 acctgcgccc ccgcatcggg cgcatgatgt aagagaaacc gaaaataaat gatactcacc 13800 aaggccatgg cgaccagcgt gcgttcgttt cttctctgtt gttgtatcta gtatgatgag 13860 gcgtgcgtac ccggagggtc ctcctccctc gtacgagagc gtgatgcagc aggcgatggc 13920 ggcggcggcg gcgatgcagc ccccgctgga ggctccttac gtgcccccgc ggtacctggc 13980 gcctacggag gggcggaaca gcattcgtta ctcggagctg gcacccttgt acgataccac 14040 ccggttgtac ctggtggaca acaagtcggc ggacatcgcc tcgctgaact accagaacga 14100 ccacagcaac ttcctgacca ccgtggtgca gaacaatgac ttcaccccca cggaggccag 14160 cacccagacc atcaactttg acgagcgctc gcggtggggc ggtcagctga aaaccatcat 14220 gcacaccaac atgcccaacg tgaacgagtt catgtacagc aacaagttca aggcgcgggt 14280 gatggtctcc cgcaagaccc ccaacggggt gacagtgaca gatggtagtc aggatatctt 14340 ggagtatgaa tgggtggagt ttgagctgcc cgaaggcaac ttctcggtga ccatgaccat 14400 cgacctgatg aacaacgcca tcatcgacaa ttacttggcg gtggggcggc agaacggggt 14460 cctggagagc gatatcggcg tgaagttcga cactaggaac ttcaggctgg gctgggaccc 14520 cgtgaccgag ctggtcatgc ccggggtgta caccaacgag gccttccacc ccgatattgt 14580 cttgctgccc ggctgcgggg tggacttcac cgagagccgc ctcagcaacc tgctgggcat 14640 tcgcaagagg cagcccttcc aggagggctt ccagatcatg tacgaggatc tggagggggg 14700 caacatcccc gcgctcctgg atgtcgacgc ctatgagaaa agcaaggagg agagcgccgc 14760 cgcggcgact gcagctgtag ccaccgcctc taccgaggtc aggggcgata attttgccag 14820 ccctgcagca gtggcagcgg ccgaggcggc tgaaaccgaa agtaagatag tcattcagcc 14880 ggtggagaag gatagcaagg acaggagcta caacgtgctg ccggacaaga taaacaccgc 14940 ctaccgcagc tggtacctgg cctacaacta tggcgacccc gagaagggcg tgcgctcctg 15000 gacgctgctc accacctcgg acgtcacctg cggcgtggag caagtctact ggtcgctgcc 15060 cgacatgatg caagacccgg tcaccttccg ctccacgcgt caagttagca actacccggt 15120 ggtgggcgcc gagctcctgc ccgtctactc caagagcttc ttcaacgagc aggccgtcta 15180 ctcgcagcag ctgcgcgcct tcacctcgct cacgcacgtc ttcaaccgct tccccgagaa 15240 ccagatcctc gtccgcccgc ccgcgcccac cattaccacc gtcagtgaaa acgttcctgc 15300 tctcacagat cacgggaccc tgccgctgcg cagcagtatc cggggagtcc agcgcgtgac 15360 cgttactgac gccagacgcc gcacctgccc ctacgtctac aaggccctgg gcatagtcgc 15420 gccgcgcgtc ctctcgagcc gcaccttcta aaaaatgtcc attctcatct cgcccagtaa 15480 taacaccggt tggggcctgc gcgcgcccag caagatgtac ggaggcgctc gccaacgctc 15540 cacgcaacac cccgtgcgcg tgcgcgggca cttccgcgct ccctggggcg ccctcaaggg 15600 ccgcgtgcgg tcgcgcacca ccgtcgacga cgtgatcgac caggtggtgg ccgacgcgcg 15660 caactacacc cccgccgccg cgcccgtctc caccgtggac gccgtcatcg acagcgtggt 15720 ggccgacgcg cgccggtacg cccgcgccaa gagccggcgg cggcgcatcg cccggcggca 15780 ccggagcacc cccgccatgc gcgcggcgcg agccttgctg cgcagggcca ggcgcacggg 15840 acgcagggcc atgctcaggg cggccagacg cgcggcctca ggcgccagcg ccggcaggac 15900 ccggagacgc gcggccacgg cggcggcagc ggccatcgcc agcatgtccc gcccgcggcg 15960 agggaacgtg tactgggtgc gcgacgccgc caccggtgtg cgcgtgcccg tgcgcacccg 16020 cccccctcgc acttgaagat gttcacttcg cgatgttgat gtgtcccagc ggcgaggatg 16080 tccaagcgca aattcaagga agagatgctc caggtcatcg cgcctgagat ctacggcccc 16140 gcggtggtga aggaggaaag aaagccccgc aaaatcaagc gggtcaaaaa ggacaaaaag 16200 gaagaagaaa gtgatgtgga cggactggtg gagtttgtgc gcgagttcgc cccccggcgg 16260 cgcgtgcagt ggcgcgggcg gaaggtgcgc ccggtgctga gaccaggcac tacggtggtc 16320 ttcacgcccg gcgagcgctc cggcaccgct tccaagcgct cctacgacga ggtgtacggg 16380 gacgaggaca tcctcgagca ggcggccgag cgcctgggcg agtttgctta cggcaagcgc 16440 agccgctccg cgccgaagga agaggcggtg tccatcccgc tggaccacgg caaccccacg 16500 ccgagcctca agcccgtgac cctgcagcag gtgctgccga ccgcggcgcc gcgccggggg 16560 ttcaagcgcg agggcgagga tctgtacccc accatgcagc tgatggtgcc caagcgccag 16620 aagctggaag acgtgctgga gaccatgaag gtggacccgg acgtgcagcc cgaggtcaag 16680 gtgcggccca tcaagcaggt ggccccgggc ctgggcgtgc agaccgtgga catcaagatc 16740 cccacggagc ccatggaaac gcagaccgag cccgtgaaac ccagcaccag caccatggag 16800 gtgcagacgg atccttggat gccatcggct actagccgaa gaccccggcg caagtacggc 16860 gcggccagcc tgctgatgcc caactacgcg ctgcatcctt ccatcatccc cacgccgggc 16920 taccgcggca cgcgcttcta ccgcggtcat acaagccgcc gccgcaagac caccacccgc 16980 cgccgccgtc gccgcacaac cgctgctgca tctacccctg ccgccctggt gcggagagtg 17040 taccgccgcg gccgcgcgcc tctgaccctg ccgcgcgcgc gctaccaccc gagcattgcc 17100 atttaaactt tcgcctgctt tgcagatcaa tggccctcac atgccgcctc cgcgttccca 17160 ttacgggcta ccgaggaaga aaaccgcgcc gtagaaggct ggcggggaac gggatgcgtc 17220 gccaccacca ccggcggcgg cgcgccatca gcaagcggtt ggggggaggc ttcctgcccg 17280 cgctgatccc catcatcgcc gcggcgatcg gggcgatccc cggcattgct tccgtggcgg 17340 tgcaggcctc tcagcgccac tgagacacac ttggaaacat cttgtaataa accaatggac 17400 tctgacgctc ctggtcctgt gatgtgtttt cgtagacaga tggaagacat caatttttcg 17460 tccctggctc cgcgacacgg cacgcggccg ttcatgggca cctggagcga catcggcacc 17520 agccaactga acgggggcgc cttcaattgg agcagtctct ggagcgggct taagaatttc 17580 gggtccacgc ttaaaaccta tggcagcaag gcgtggaaca gcaccacagg gcaggcgctg 17640 agggataagc tgaaagagca gaacttccag cagaaggtgg tcgatggcct ggcctcgggc 17700 atcaacgggg tggtggacct ggccaaccag gccgtgcagc ggcagatcaa cagccgcctg 17760 gacccggtgc cgcccgccgg ctccgtggag atgccgcagg tggaggagga gctgcctccc 17820 ctggacaagc ggggcgagaa gcgaccccgc cccgacgcgg aggagacgct gctgacgcac 17880 acggacgagc cgcccccgta cgaggaggcg gtgaaactgg gcctgcccac cacgcggccc 17940 atcgcgcctc tggccaccgg ggtgctgaaa cccgaaagta gtaagcccgc gaccctggac 18000 ttgcctcctc cccagccttc ccgcccctcc acagtggcta agcctctgcc gccggtggcc 18060 gtggcccgcg cgcgacccgg gggcaccgcc cgccctcatg cgaactggca gagcactctg 18120 aacagcatcg tgggtctggg agtgcagagt gtgaagcgcc gccgctgcta ttaaacctac 18180 cgtagcgctt aacttgcttg tctgtgtgtg tatgtattat gtcgccgccg ctgtcgccag 18240 aaggaggagt gaagaggcgc gtcgccgagt tgcaagatgg ccaccccatc gatgctgccc 18300 cagtgggcgt acatgcacat cgccggacag gacgcttcgg agtacctgag tccgggtctg 18360 gtgcagttcg cccgcgccac agacacctac ttcagtctgg ggaacaagtt taggaacccc 18420 acggtggcgc ccacgcacga tgtgaccacc gaccgcagcc agcggctgac gctgcgcttc 18480 gtgcccgtgg accgcgagga caacacctac tcgtacaaag tgcgctacac gctggccgtg 18540 ggcgacaacc gcgtgctgga catggccagc acctactttg acatccgcgg cgtgctggac 18600 cggggcccta gcttcaaacc ctactccggc accgcctaca atgctctggc ccccaaggga 18660 gcacccaaca cttgccagtg gacatacaca gataagcaaa ccgaaaaaac agccacgtat 18720 gggaatgcgc ctgtacaagg cattgccatc acaaaagatg gtattcaact tggaactgac 18780 agtgatggaa atcctgtata tgctcaaaag acatttgaac ccgaacctca agtgggtgat 18840 gcagaatggc atgacactac aggtacagat gaaaagtatg gaggcagggc acttaagcct 18900 gacaccaaaa tgaagccttg ctatggttct tttgccaaac ccactaacaa agaaggtgga 18960 caggcaaaga acagaacaaa aactgatgga actggcgaag agcctgatat tgatatggca 19020 ttttttgacg gcagaaatgc aactacagct ggtttggctc cagaaattgt tttgtatact 19080 gagaatgtgg atctggagac tccagatacc catattgtat acaaagcagg cacagatgac 19140 agcagctctt cgattaattt ggggcagcaa tccatgccca acagacccaa ctacattggg 19200 ttcagagaca actttatcgg gctcatgtac tacaacagca ctggcaatat gggggtgctg 19260 gccggtcagg cttctcagct gaatgctgtg gttgacttgc aagacagaaa caccgaactg 19320 tcctaccagc tcttgcttga ctctctgggc gacagaaccc tgtatttcag tatgtggaat 19380 caggcggtgg acagctatga tcctgatgtg cgcattattg aaaaccatgg tgtggaagat 19440 gaacttccca actattgctt ccctctggat gctgttggta ggacagatac ttatcaggga 19500 attaagccca atggaggcga tccagccaca tgggccaaag atgacagcgc caatgatgct 19560 aatgaaatgg gcaagggcaa tccattcgcc atggaaatca acatccaagc caacctgtgg 19620 aggaacttcc tctacgccaa cgtggccctg tacctacccg attcttacaa gtacacgccg 19680 gccaacgtca ccctgcccac caacaccaac acctacgatt atatgaacgg ccgggtggtg 19740 gcgccttcgc tggtggactc ctacatcaac atcggggcgc gctggtcgct ggaccccatg 19800 gacaacgtca atcccttcaa ccaccaccgc aacgcgggct tgcgctaccg ctccatgctc 19860 ctgggcaacg ggcgctacgt gcccttccac atccaggtgc cccagaaatt tttcgccatc 19920 aagagcctcc tgctcctgcc cgggtcctac acctacgagt ggaacttccg caaggacgtc 19980 aacatgatcc tgcagagctc cctcggcaac gacctgcgca cggacggggc ctccatctcc 20040 ttcaccagca tcaacctcta cgccaccttc ttccccatgg cgcacaacac ggcctccacg 20100 ctcgaggcca tgctgcgcaa cgacaccaac gaccagtcct tcaacgacta cctctcggcg 20160 gccaacatgc tctaccccat cccggccaac gccaccaacg tgcccatctc catcccctcg 20220 cgcaactggg ccgccttccg cggctggtcc ttcacgcgcc tcaagaccaa ggagacgccc 20280 tcgctgggct ccgggttcga cccctacttc gtctactcgg gctccatccc ctacctcgac 20340 ggcaccttct acctcaacca caccttcaag aaggtctcca tcaccttcga ctcctccgtc 20400 agctggcccg gcaacgaccg gctcctgacg cccaacgagt tcgaaatcaa gcgcaccgtc 20460 gacggcgagg gctacaacgt ggcccagtgc aacatgacca aggactggtt cctggtccag 20520 atgctggccc actacaacat cggctaccag ggcttctacg tgcccgaggg ctacaaggac 20580 cgcatgtact ccttcttccg caacttccag cccatgagcc gccaggtggt ggacgaggtc 20640 aactacaagg actaccaggc cgtcaccctg gcctaccagc acaacaactc gggcttcgtc 20700 ggctacctcg cgcccaccat gcgccagggc cagccctacc ccgccaacta cccgtacccg 20760 ctcatcggca agagcgccgt caccagcgtc acccagaaaa agttcctctg cgacagggtc 20820 atgtggcgca tccccttctc cagcaacttc atgtccatgg gcgcgctcac cgacctcggc 20880 cagaacatgc tctatgccaa ctccgcccac gcgctagaca tgaatttcga agtcgacccc 20940 atggatgagt ccacccttct ctatgttgtc ttcgaagtct tcgacgtcgt ccgagtgcac 21000 cagccccacc gcggcgtcat cgaggccgtc tacctgcgca cccccttctc ggccggtaac 21060 gccaccacct aaattgctac ttgcatgatg gctgaggccg cgggctccgg cgagcaggag 21120 ctcagggcca tcatccgcga cctgggctgc gggccctact tcctgggcac cttcgataag 21180 cgcttcccgg gattcatggc cccgcacaag ctggcctgcg ccatcgtcaa cacggccggt 21240 cgcgagaccg ggggcgagca ctggctggcc ttcgcctgga acccgcgctc gaacacctgc 21300 tacctcttcg accccttcgg gttctcggac gagcgcctca agcagatcta ccagttcgag 21360 tacgagggcc tgctgcgccg cagcgccctg gccaccgagg accgctgcgt caccctggaa 21420 aagtccaccc agaccgtgca gggtccgcgc tcggccgcct gcgggctctt ctgctgcatg 21480 ttcctgcacg ccttcgtgca ctggcccgac cgccccatgg acaagaaccc caccatgaac 21540 ttgctgacgg gggtgcccaa cggcatgctc cagtcgcccc aggtggaacc caccctgcgc 21600 cgcaaccagg aggcgctcta ccgcttcctc aactcccact ccgcctactt tcgctcccac 21660 cgcgcgcgca tcgagaaggc caccgccttc gatcgcatga acaatcaaga catgtaaacc 21720 gtgtgtgtat gtttaaaata tcttttaata aacagcactt tcatgttaca catgcatctg 21780 agatgattat ttagaaatcg aaagggttct gccgggtctc ggcatggccc gcgggcaggg 21840 acacgttgcg gaactggtac ttggccagcc acttgaactc ggggatcagc agtttcggca 21900 gcggggtgtc ggggaaggag tcggtccaca gcttccgcgt cagttgcagg gcgcccagca 21960 ggtcgggcgc ggagatcttg aaatcgcagt tgggacccgc gttctgcgcg cgagagttgc 22020 ggtacacggg gttgcagcac tggaacacca tcagggccgg gtgcttcacg ctcgccagca 22080 ccgtcgcgtc ggtgatgctc tccacgtcga ggtcctcggc gttggccatc ccgaaggggg 22140 tcatcttgca ggtctgcctt cccatagtgg gcacgcaccc gggcttgtgg ttgcaatcgc 22200 agtgcagggg gatcagcatc atctgggcct ggtcggcgtt catccccggg tacatggcct 22260 tcatgaaagc ctccaattgc ctgaaagcct gctgggcctt ggctccctcg gtgaagaaga 22320 ccccgcagga cttgctagag aactggttgg tagcgcaccc ggcgtcgtgc acgcagcagc 22380 gcgcgtcgtt gttggccagc tgcaccacgc tgcgccccca gcggttctgg gtgatcttgg 22440 cccggtcggg gttctccttc agcgcgcgct gcccgttctc gctcgccaca tccatctcga 22500 tcatgtgctc cttctggatc atggtggtcc cgtgcaggca ccgcagcttg ccctcggtct 22560 cggtgcaccc gtgcagccac agcgcgcacc cggtgcactc ccagttcttg tgggcgatct 22620 gggaatgcgc gtgcacgaac ccctgcagga agcggcccat catggtggtc agggtcttgt 22680 tgctagtgaa ggtcagcggg atgccgcggt gctcctcgtt gatgtacagg tggcagatgc 22740 ggcggtacac ctcgccctgc tcgggcatca gctggaagtt ggctttcagg tcggtctcca 22800 cgcggtagcg gtccatcagt atagtcatga tttccatacc cttctcccag gccgagacga 22860 tgggcaggct catagggttc ttcaccatca tcttagcact agcagccgcg gccagggggt 22920 cgctctcatc cagggtctca aagctccgct tgccgtcctt ctcggtgatc cgcaccgggg 22980 ggtagctgaa gcccacggcc gccagctcct cctcggcctg cctttcgtcc tcgctgtcct 23040 ggctgacgtc ctgcaggacc acatgcttgg tcttgcgggg tttcttcttg ggcggcagcg 23100 gcggcggaga tgcttgtggc gagggggagc gcgagttctc gctcaccact actatctctt 23160 cctcttcgtg gtccgaggcc acgcggcggt aggtatgtct cttcgggggc agaggcggag 23220 gcgacgggct ctcgccgccg cgacttggcg gatggctggc agagcccctt ccgcgatcgg 23280 gggtgcgctc ccggcggcgc tctgactgac ttcctccgcg gccggccatt gtgttctcct 23340 agggaggaac aacaagcatg gagactcagc catcgccaac ctcgccatct gcccccacca 23400 ccgccgacga gaagcagcag aatgaaagct taaccgcccc gccgcccagc cccgccacct 23460 ccgacgcagc cgcggtccca gacatgcaag agatggagga atccatcgag attgacctgg 23520 gctatgtgac gcccgcggag cacgaggagg agctggcagt gcgctttcaa tcgtcaagcc 23580 aggaagataa agaacagcca gagcaggaag cagaaaacga gcagagtcag gctgggctcg 23640 agcatgacgg cgactacctc cacctgagcg gggaggagga cgcgctcatc aagcatctgg 23700 cccggcaggc catcatcgtc aaggatgcgc tgctcgaccg caccgaggtg cccctcagcg 23760 tggaggagct cagccgcgcc tacgagctca acctcttctc gccgcgcgtg ccccccaagc 23820 gccagcccaa cggcacctgc gagcccaacc cgcgcctcaa cttctacccg gtcttcgcgg 23880 tgcccgaggc cctggccacc taccacatct ttttcaagaa ccaaaagatc cccgtctcct 23940 gtcgcgccaa ccgcacccgc gccgacgccc tcttcaacct gggccccggc gcccgcctac 24000 ctgatatcgc ctccttggaa gaggttccca agatcttcga gggtctgggc agcgacgaga 24060 ctcgggccgc aaacgctctg caaggagaag gaggagagca tgagcaccac agcgccctgg 24120 tcgagttgga aggcgacaac gcgcggctgg cggtgctcaa acgcacggtc gagctgaccc 24180 atttcgccta cccggctctg aacctgcccc ccaaagtcat gagcgcggtc atggaccagg 24240 tgctcatcaa gcgcgcgtcg cccatctccg aggacgaggg catgcaagac tccgaggatg 24300 gcaagcccgt ggtcagcgac gagcagctgg cccggtggct gggtcctaat gctagtcccc 24360 agagtttgga agagcggcgc aagctcatga tggccgtggt cctggtgacc gtggagctgg 24420 agtgcctgcg ccgcttcttc gccgacgcgg agaccctgcg caaggtcgag gagaacctgc 24480 actacctctt caggcacggg ttcgtgcgcc aggcctgcaa gatctccaac gtggagctga 24540 ccaacctggt ctcctacatg ggcatcttgc acgagaaccg cctggggcag aacgtgctgc 24600 acaccaccct gcgcggggag gcccgccgcg actacatccg cgactgcgtc tacctctacc 24660 tctgccacac ctggcagacg ggcatgggcg tgtggcagca gtgtctggag gagcagaacc 24720 tgaaagagct ctgcaagctc ctgcagaaga acctcaaggg tctgtggacc gggttcgacg 24780 agcggaccac cgcctcggac ctggccgacc tcatcttccc cgagcgcctc aggctgacgc 24840 tgcgcaacgg cctgcccgac tttatgagcc aaagcatgtt gcaaaacttt cgctctttca 24900 tcctcgaacg ctccggaatc ctgcccgcca cctgctccgc gctgccctcg gacttcgtgc 24960 cgctgacctt ccgcgagtgc cccccgccgc tgtggagcca ctgctacctg ctgcgcctgg 25020 ccaactacct ggcctaccac tcggacgtga tcgaggacgt cagcggcgag ggcctgcttg 25080 agtgccactg ccgctgcaac ctctgcacgc cgcaccgctc cctggcctgc aacccccagc 25140 tgctgagcga gacccagatc atcggcacct tcgagttgca agggcccagc gatgacggcg 25200 agggagccaa ggggggtctg aaactcaccc cggggctgtg gacctcggcc tacttgcgca 25260 agttcgtgcc cgaggactac catcccttcg agatcaggtt ctacgaggac caatcccagc 25320 cgcctaaggc cgagctgtcg gcctgcgtca tcacccaggg ggccatcctg gcccaattgc 25380 aagccatcca gaaatcccgc caagaattct tgctgaaaaa gggccgcggg gtctacctcg 25440 acccccagac cggtgaggag ctcaaccccg gcttccccca gg atg ccc cga gga 25494 Met Pro Arg Gly 1 aac aag aag ctg aaa gtg gag ctg ccg ccc gtg gag gat ttg gag gaa 25542 Asn Lys Lys Leu Lys Val Glu Leu Pro Pro Val Glu Asp Leu Glu Glu 5 10 15 20 gac tgg gag aac agc agt cag gca gag gag gag atg gag gaa gac tgg 25590 Asp Trp Glu Asn Ser Ser Gln Ala Glu Glu Glu Met Glu Glu Asp Trp 25 30 35 gac agc act cag gca gag gag gac agc ctg caa gac agt ctg gag gaa 25638 Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser Leu Glu Glu 40 45 50 gac gag gag gag gca gag gtg gaa gaa gca gcc gcc gcc aga ccg tcg 25686 Asp Glu Glu Glu Ala Glu Val Glu Glu Ala Ala Ala Ala Arg Pro Ser 55 60 65 tcc tcg gcg ggg gag aaa gca agc agc acg gat acc atc tcc gct ccg 25734 Ser Ser Ala Gly Glu Lys Ala Ser Ser Thr Asp Thr Ile Ser Ala Pro 70 75 80 ggt cgg ggt ccc gct cgg ccc cac agt aga tgg gac gag acc ggg cga 25782 Gly Arg Gly Pro Ala Arg Pro His Ser Arg Trp Asp Glu Thr Gly Arg 85 90 95 100 ttc ccg aac ccc acc atc cag acc ggt aag aag gag cgg cag gga tac 25830 Phe Pro Asn Pro Thr Ile Gln Thr Gly Lys Lys Glu Arg Gln Gly Tyr 105 110 115 aag tcc tgg cgg ggg cac aaa aac gcc atc gtc tcc tgc ttg cag gcc 25878 Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser Cys Leu Gln Ala 120 125 130 tgc ggg ggc aac atc tcc ttc acc agg cgc tac ctg ctc ttc cac cgc 25926 Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu Leu Phe His Arg 135 140 145 ggg gtg aac ttc ccc cgc aac atc ttg cat tac tac cgt cac ctc cac 25974 Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr Arg His Leu His 150 155 160 agc ccc tac tac ttc caa gaa gag gca gca gca gaa aaa gac cag cag 26022 Ser Pro Tyr Tyr Phe Gln Glu Glu Ala Ala Ala Glu Lys Asp Gln Gln 165 170 175 180 aaa acc agc agc tagaaaatcc acagcggcag caggtggact gaggatcgcg 26074 Lys Thr Ser Ser gcgaacgagc cggcgcagac ccgggagctg aggaaccgga tctttcccac cctctatgcc 26134 atcttccagc agagtcgggg gcaggagcag gaactgaaag tcaagaaccg ttctctgcgc 26194 tcgctcaccc gcagttgtct gtatcacaag agcgaagacc aacttcagcg cactctcgag 26254 gacgccgagg ctctcttcaa caagtactgc gcgctcactc ttaaagagta gcccgcgccc 26314 gcccagtcgc agaaaaaggc gggaattacg tcacctgtgc ccttcgccct agccgcctcc 26374 acccatcatg agcaaagaga ttcccacgcc ttacatgtgg agctaccagc cccagatggg 26434 cctggccgcc ggcgccgccc aggactactc cacccgcatg aattggctca gcgccgggcc 26494 cgcgatgatc tcacgggtga atgacatccg cgcccaccga aaccagatac tcctagaaca 26554 gtcagcgctc accgccacgc cccgcaatca cctcaatccg cgtaattggc ccgccgccct 26614 ggtgtaccag gaaattcccc agcccacgac cgtactactt ccgcgagacg cccaggccga 26674 agtccagctg actaactcag gtgtccagct ggcgggcggc gccaccctgt gtcgtcaccg 26734 ccccgctcag ggtataaagc ggctggtgat ccggggcaga ggcacacagc tcaacgacga 26794 ggtggtgagc tcttcgctgg gtctgcgacc tgacggagtc ttccaaatcg ccggatcggg 26854 gagatcttcc ttcacgcctc gtcaggcggt cctgactttg gagagttcgt cctcgcagcc 26914 ccgctcgggc ggcatcggca ctctccagtt cgtggaggag ttcactccct cggtctactt 26974 caaccccttc tccggctccc ccggccacta cccggacgag ttcatcccga actttgacgc 27034 catcagcgag tcggtggacg gctacgattg aatgtcccat ggtggcgcgg ctgacctagc 27094 tcggcttcga cacctggacc actgccgccg ctttcgctgc ttcgctcggg acctcgccga 27154 gttcacctac ttcgagctgc ccgaggagca tcctcagggc ccggcccacg gagtgcggat 27214 cgtcgtcgaa gggggcctag actcccacct gcttcggatc ttcagccagc gcccgatcct 27274 ggtcgagcgc caacagggca acaccctcct gaccctctac tgcatctgcg accaccccgg 27334 cctgc atg aaa gtc ttt gtt gtc tgc tgt gta ctg agt ata ata aaa gct 27384 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala 185 190 195 gag atc agc gac tac tcc gga ctc aac tgt ggt gtt tct gca tcc atc 27432 Glu Ile Ser Asp Tyr Ser Gly Leu Asn Cys Gly Val Ser Ala Ser Ile 200 205 210 215 aac cag tct ctg acc ttc acc ggg aac gag acc gag ctc cag ctc cag 27480 Asn Gln Ser Leu Thr Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln 220 225 230 tgt aag ccc cac aag aag tac ctc acc tgg ctg tac cag ggc tcc ccg 27528 Cys Lys Pro His Lys Lys Tyr Leu Thr Trp Leu Tyr Gln Gly Ser Pro 235 240 245 atc gcc gtt gtt aac cac tgc gac gac gac gga gtc ctg ctg aac ggc 27576 Ile Ala Val Val Asn His Cys Asp Asp Asp Gly Val Leu Leu Asn Gly 250 255 260 ccc gcc aac ctt act ttt tcc acc cgc aga agc aag cta ctg ctc ttc 27624 Pro Ala Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Leu Leu Phe 265 270 275 aga ccc ttc ctc ccc ggg atc tat cag tgc atc tcg gga ccc tgc cat 27672 Arg Pro Phe Leu Pro Gly Ile Tyr Gln Cys Ile Ser Gly Pro Cys His 280 285 290 295 cac acc ttc cac ctg atc ccg aat acc acc tct tcc cca gca ccg ctc 27720 His Thr Phe His Leu Ile Pro Asn Thr Thr Ser Ser Pro Ala Pro Leu 300 305 310 ccc act aac aac caa act aac cac caa cgc cac cgt cga gac ctt tcc 27768 Pro Thr Asn Asn Gln Thr Asn His Gln Arg His Arg Arg Asp Leu Ser 315 320 325 tct gat tct aat acc act acc gga ggt gag ctc cga ggt act aag aag 27816 Ser Asp Ser Asn Thr Thr Thr Gly Gly Glu Leu Arg Gly Thr Lys Lys 330 335 340 tcc tca cct ggg att tat tac ggc ccc tgg gag gtg gtg ggg tta ata 27864 Ser Ser Pro Gly Ile Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile 345 350 355 gct tta ggc tta gta gcg ggt ggg ctt ttg gct ctc tgc tac cta tac 27912 Ala Leu Gly Leu Val Ala Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr 360 365 370 375 ctc cct tgc tgt tcc tac tta gtg gtg ctt tgt tgc tgg ttt aag aaa 27960 Leu Pro Cys Cys Ser Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys 380 385 390 tgg gga aga tca ccc tagtgtgcgg tgtgctggtg acggtggtgc tttcgattct 28015 Trp Gly Arg Ser Pro 395 gggaggggga agcgcggctg tagtgacgga gaagaaggcc gatccctgct tgactttcaa 28075 tcccgataaa tgccggctga gttttcagcc agatggcaat cggtgcacgg tgctgatcaa 28135 gtgcggatgg gaatgcgaga gcgtggcgat ccagtataaa aacaagacgc ggaacaatac 28195 tctcgcgtcc acatggcagc ccggggaccc cgagtggtac accgtctctg tccctggtgc 28255 tgacggctcc ctccacacgg tgaacaacac tttcattttt gagcacatgt gcgaaaccgc 28315 catgttcatg agcaagcagt acggtatgtg gcccccacga aaagagaata tcgtggtctt 28375 ctccatcgct tacagcgcgt gcacggtgct aatcaccgcg atcgtgtgcc tgagcattca 28435 catgctcatc gctattcgcc ccagaaataa tgccgagaaa gagaaacagc cataacacac 28495 ttttttcaca caccttgttt tttacagaca atgcgtctgt taatttttgt tatcattaca 28555 ctcagcttta actatgccca tggctatgca aatatacaaa aaaccctcta tgtaggctct 28615 gactctacat tagaaggtac tcaatctcaa gccagggttt catggtattt ttataaaggc 28675 tctgatgacc caattactct ttgcaaaggt gatcaggggc gcataacaaa gccacctatc 28735 acatttagct gcaccagaac aaacctcacg cttttatcca ttacaaaaga atatgctggc 28795 acttattaca gcacaaattt tcatcgtggg caagataaat attatactgt taaggtagaa 28855 aaccctacca cccctagaac aactacaaag cccaccacaa ctaagaagcc cactacacct 28915 aagaagccta ccacacccaa aaccactaag acaacaactg ctaagaccac taccacaaag 28975 ccaaccacaa ccagcaccac acttgctata actacacaca cacacactga gctgacctca 29035 caggcaacta ctgaaaatga tttggttgcc ctgttgcaaa agggggagaa cagtagcagc 29095 agtcctctgc ctactacccc cagtgaggaa atacccaagt ccatggttgg cattatcgct 29155 gctgtagtgg tgtgtatgct gattatcatc ttgtgcatga tgtactatgc ctgctactac 29215 agaaaacaca ggctgaacaa caaactggac cccttactga gtgttgattt ttaatttttt 29275 agaaccatga agatcctaag cctttttgtt ttttctataa ttattacctc tgctatttgt 29335 gaatcagtgg ataaggacgt tactgtcacc actggctcta attatacact aaaagggcct 29395 tcctcaggta tgctttcgtg gtattgttat tttggaaatg atgataaaca gacagagcta 29455 tgtaactttc agaacggcaa aaccaaaaat tctaaaatag ataactatca atgccagggt 29515 actaatttag tactgatgaa tatcacgaaa gcatatgctg gcagttattc ctgtcctgga 29575 caaaacaccg aggaaatgat tttttacaaa ttaattgtag ttgaccctac tactccagca 29635 ccacccacca caaccaaggc acataccaca gacacacagg aaaccactcc agaggcagaa 29695 gtagcagagt tagcaaagca gattcatgaa gattcatttg ttgccaatac ccccacacac 29755 cccggaccgc aatgtccagg gccattagtc agcggcattg tcggtgtgct ttgcgggtta 29815 gcagttataa tcatctgcat gttcattttt gcttgctgct acagaaggct tcaccgacaa 29875 aaatcagacc cactgctgaa cctctatgtt taatttttga ttttccagag ccatgaaggc 29935 acttagcact ttagtatttt tgtccttgat tggcattgtt ttcagtgctg ggtttttgaa 29995 aaatcttacc attattgaag gtgataatgc aacactggta ggaatcagcg gtcagaatgt 30055 tagttggcta aaatatcatc tagatgggtg gaaacctatt tgcacctgga atgtcagtgt 30115 gtacacatgc catggtgtta acctcaccat taccaatgcc acccaagatc agaatggcag 30175 gtttaagggt cagagtttca ctagcaacaa tgggtatgaa acccataaca tgttcatcta 30235 tgatgtcact gtcatatcaa ataagactac acctaccaca cagacaccca ctacacatag 30295 ctcaactcat gccatgcaga ccactcagac aaccacatac actacatcta ctgagtccac 30355 caccaccact acagcagagg tatccagcac agcgcctcag ccccaggcat tggctttgat 30415 ggctcagcct agcagcatga ctgctaaaac caatgagcag actactgaat ttttgtccac 30475 tattcagagc agcaccacag ctacctcgag tgccttctct agcaccgcca atctcacctc 30535 gctttcctct acgccaatca gtaacgctac tacctccccc gctcctcttc ccactcctct 30595 gaagcaatcc gagtctagca cgcagctgca gatcaccctg ctcattgtga tcggggtggt 30655 catcctggca gtgctgctct actttatctt ctgccgccgc atccccaacg cgaaaccggc 30715 ctacaagccc attgttatcg ggacgccgga gccgcttcag gtggagggag gtctaaggaa 30775 tcttctcttc tcttttacag tatggtgatt tgaactatga ttcctagaca tttcattatc 30835 acttctctaa tctgtgtgct ccaagtctgt gccaccctcg ctctcgtggc taacgcgagt 30895 ccagactgca ttggagcgtt cgcctcctac gtgctctttg ccttcatcac ctgcatctgc 30955 tgctgtagca tagtctgcct gcttatcacc ttcttccagt tcgttgactg ggtctttgtg 31015 cgcatcgcct acctgcgcca ccacccccag taccgcgacc agagagtggc gcaactgttg 31075 agactcatct gatgataagc atgcgggctc tgctactact tctcgcgctt ctgctagctc 31135 ccctcgccgc ccccctatcc ctcaaatccc ccacccagtc ccctgaagag gttcgaaaat 31195 gtaaattcca agaaccctgg aaattccttt catgctacaa actcaaatca gaaatgcacc 31255 ccagctggat catgatcgtt ggaatcgtaa acatccttgc ctgtaccctc ttctcctttg 31315 tgatttaccc ccgctttgac tttgggtgga acgcacccga ggcgctctgg ctcccgcctg 31375 atcccgacac accaccacag cagcagcaaa atcaggcaca ggcacatgca ccaccacagc 31435 ctaggccaca atacatgccc atcttagact atgaggccga gccacagcga gccatgcttc 31495 ctgctattag ttacttcaat ctaaccggcg gag atg act gac ccc atg gcc aac 31549 Met Thr Asp Pro Met Ala Asn 400 aac acc gtc aac gac ctc ctg gac atg gac ggc cgc gcc tcg gag cag 31597 Asn Thr Val Asn Asp Leu Leu Asp Met Asp Gly Arg Ala Ser Glu Gln 405 410 415 cga ctc gcc caa ctc cgc atc cgc cag cag cag gag aga gcc gtc aag 31645 Arg Leu Ala Gln Leu Arg Ile Arg Gln Gln Gln Glu Arg Ala Val Lys 420 425 430 435 gag ctg cag gac gcg gtg gcc atc cac cag tgc aag aga ggc atc ttc 31693 Glu Leu Gln Asp Ala Val Ala Ile His Gln Cys Lys Arg Gly Ile Phe 440 445 450 tgc ctg gtg aag cag gcc aag atc tcc ttc gag gtc acg tcc acc gac 31741 Cys Leu Val Lys Gln Ala Lys Ile Ser Phe Glu Val Thr Ser Thr Asp 455 460 465 cat cgc ctc tcc tac gag ctc ctg cag cag cgc cag aag ttc acc tgc 31789 His Arg Leu Ser Tyr Glu Leu Leu Gln Gln Arg Gln Lys Phe Thr Cys 470 475 480 ctg gtc gga gtc aac ccc atc gtc atc acc cag cag tct ggc gat acc 31837 Leu Val Gly Val Asn Pro Ile Val Ile Thr Gln Gln Ser Gly Asp Thr 485 490 495 aag ggt tgc atc cac tgc tcc tgc gac tcc ccc gag tgc gtt cac acc 31885 Lys Gly Cys Ile His Cys Ser Cys Asp Ser Pro Glu Cys Val His Thr 500 505 510 515 ctg atc aag acc ctc tgc ggc ctc cgc gac ctc ctc ccc atg aac 31930 Leu Ile Lys Thr Leu Cys Gly Leu Arg Asp Leu Leu Pro Met Asn 520 525 530 taatcaacta accccctacc cctttaccct ccagtaaaaa taaagattaa 31980 <210> 195 <211> 184 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 195 Met Pro Arg Gly Asn Lys Lys Leu Lys Val Glu Leu Pro Pro Val Glu 1 5 10 15 Asp Leu Glu Glu Asp Trp Glu Asn Ser Ser Gln Ala Glu Glu Glu Met 20 25 30 Glu Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp 35 40 45 Ser Leu Glu Glu Asp Glu Glu Glu Ala Glu Val Glu Glu Ala Ala Ala 50 55 60 Ala Arg Pro Ser Ser Ser Ala Gly Glu Lys Ala Ser Ser Thr Asp Thr 65 70 75 80 Ile Ser Ala Pro Gly Arg Gly Pro Ala Arg Pro His Ser Arg Trp Asp 85 90 95 Glu Thr Gly Arg Phe Pro Asn Pro Thr Ile Gln Thr Gly Lys Lys Glu 100 105 110 Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser 115 120 125 Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu 130 135 140 Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr 145 150 155 160 Arg His Leu His Ser Pro Tyr Tyr Phe Gln Glu Glu Ala Ala Ala Glu 165 170 175 Lys Asp Gln Gln Lys Thr Ser Ser 180 <210> 196 <211> 212 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 196 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Asn Cys Gly Val Ser Ala Ser Ile Asn 20 25 30 Gln Ser Leu Thr Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys 35 40 45 Lys Pro His Lys Lys Tyr Leu Thr Trp Leu Tyr Gln Gly Ser Pro Ile 50 55 60 Ala Val Val Asn His Cys Asp Asp Asp Gly Val Leu Leu Asn Gly Pro 65 70 75 80 Ala Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Leu Leu Phe Arg 85 90 95 Pro Phe Leu Pro Gly Ile Tyr Gln Cys Ile Ser Gly Pro Cys His His 100 105 110 Thr Phe His Leu Ile Pro Asn Thr Thr Ser Ser Pro Ala Pro Leu Pro 115 120 125 Thr Asn Asn Gln Thr Asn His Gln Arg His Arg Arg Asp Leu Ser Ser 130 135 140 Asp Ser Asn Thr Thr Thr Gly Gly Glu Leu Arg Gly Thr Lys Lys Ser 145 150 155 160 Ser Pro Gly Ile Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala 165 170 175 Leu Gly Leu Val Ala Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu 180 185 190 Pro Cys Cys Ser Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp 195 200 205 Gly Arg Ser Pro 210 <210> 197 <211> 134 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 197 Met Thr Asp Pro Met Ala Asn Asn Thr Val Asn Asp Leu Leu Asp Met 1 5 10 15 Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg Gln 20 25 30 Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Ala Val Ala Ile His 35 40 45 Gln Cys Lys Arg Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile Ser 50 55 60 Phe Glu Val Thr Ser Thr Asp His Arg Leu Ser Tyr Glu Leu Leu Gln 65 70 75 80 Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val Ile 85 90 95 Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys Asp 100 105 110 Ser Pro Glu Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu Arg 115 120 125 Asp Leu Leu Pro Met Asn 130 <210> 198 <211> 5315 <212> DNA <213> Artificial Sequence <220> <223> pSh-HIV-short-gag - based on HIV <220> <221> enhancer <222> (350)..(610) <223> Enhancer <220> <221> misc_feature <222> (611)..(838) <223> CMV\promoter <220> <221> TATA_signal <222> (812)..(815) <223> TATA <220> <221> CDS <222> (934)..(2025) <223> Gag\short <220> <221> polyA_signal <222> (2178)..(2380) <223> BGH-PolyA <220> <221> misc_feature <222> (2453)..(2491) <223> PI-Sce\I\recognition\site <220> <221> misc_feature <222> (2713)..(3356) <223> ColE1-Ori <220> <221> misc_feature <222> (4030)..(4845) <223> Kanamycin-r complement (4030..4845) <400> 198 ggtagcgaaa gctcagatct ggatctcccg atcccctatg gcgactctca gtacaatctg 60 ctctgatgcc gcatagttaa gccagtatct gctccctgct tgtgtgttgg aggtcgctga 120 gtagtgcgcg agcaaaattt aagctacaac aaggcaaggc ttgaccgaca attgcatgaa 180 gaatctgctt agggttaggc gttttgcgct gcttcgcgat gtacgggcca gatatacgcg 240 ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag 300 cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc 360 caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg 420 gactttccat tgacgtcaat gggtggacta tttacggtaa actgcccact tggcagtaca 480 tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc 540 ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt 600 attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata 660 gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt 720 ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca 780 aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg 840 tcagatcgcc tggagacgcc atccacgctg ttttgacctc catagaagac accgggaccg 900 atccagcctc cgcgggcgcg cgtcgacaga gag atg ggt gcg aga gcg tca gta 954 Met Gly Ala Arg Ala Ser Val 1 5 tta agc ggg gga gaa tta gat cga tgg gaa aaa att cgg tta agg cca 1002 Leu Ser Gly Gly Glu Leu Asp Arg Trp Glu Lys Ile Arg Leu Arg Pro 10 15 20 ggg gga aag aag aag tac aag cta aag cac atc gta tgg gca agc agg 1050 Gly Gly Lys Lys Lys Tyr Lys Leu Lys His Ile Val Trp Ala Ser Arg 25 30 35 gag cta gaa cga ttc gca gtt aat cct ggc ctg tta gaa aca tca gaa 1098 Glu Leu Glu Arg Phe Ala Val Asn Pro Gly Leu Leu Glu Thr Ser Glu 40 45 50 55 ggc tgt aga caa ata ctg gga cag cta caa cca tcc ctt cag aca gga 1146 Gly Cys Arg Gln Ile Leu Gly Gln Leu Gln Pro Ser Leu Gln Thr Gly 60 65 70 tca gag gag ctt cga tca cta tac aac aca gta gca acc ctc tat tgt 1194 Ser Glu Glu Leu Arg Ser Leu Tyr Asn Thr Val Ala Thr Leu Tyr Cys 75 80 85 gtg cac cag cgg atc gag atc aag gac acc aag gaa gct tta gac aag 1242 Val His Gln Arg Ile Glu Ile Lys Asp Thr Lys Glu Ala Leu Asp Lys 90 95 100 ata gag gaa gag caa aac aag tcc aag aag aag gcc cag cag gca gca 1290 Ile Glu Glu Glu Gln Asn Lys Ser Lys Lys Lys Ala Gln Gln Ala Ala 105 110 115 gct gac aca gga cac agc aat cag gtc agc caa aat tac cct ata gtg 1338 Ala Asp Thr Gly His Ser Asn Gln Val Ser Gln Asn Tyr Pro Ile Val 120 125 130 135 cag aac atc cag ggg caa atg gta cat cag gcc ata tca cct aga act 1386 Gln Asn Ile Gln Gly Gln Met Val His Gln Ala Ile Ser Pro Arg Thr 140 145 150 tta aat gca tgg gta aaa gta gta gaa gag aag gct ttc agc cca gaa 1434 Leu Asn Ala Trp Val Lys Val Val Glu Glu Lys Ala Phe Ser Pro Glu 155 160 165 gtg ata ccc atg ttt tca gca tta tca gaa gga gcc acc cca cag gac 1482 Val Ile Pro Met Phe Ser Ala Leu Ser Glu Gly Ala Thr Pro Gln Asp 170 175 180 ctg aac acg atg ttg aac acc gtg ggg gga cat caa gca gcc atg caa 1530 Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln Ala Ala Met Gln 185 190 195 atg tta aaa gag acc atc aat gag gaa gct gca gat tgg gat aga gtg 1578 Met Leu Lys Glu Thr Ile Asn Glu Glu Ala Ala Asp Trp Asp Arg Val 200 205 210 215 cat cca gtg cat gca ggg cct att gca cca ggc cag atg aga gaa cca 1626 His Pro Val His Ala Gly Pro Ile Ala Pro Gly Gln Met Arg Glu Pro 220 225 230 agg gga agt gac ata gca gga act act agt acc ctt cag gaa caa ata 1674 Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Thr Leu Gln Glu Gln Ile 235 240 245 gga tgg atg aca aat aat cca cct atc cca gta gga gag atc tac aag 1722 Gly Trp Met Thr Asn Asn Pro Pro Ile Pro Val Gly Glu Ile Tyr Lys 250 255 260 agg tgg ata atc ctg gga ttg aac aag atc gtg agg atg tat agc cct 1770 Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg Met Tyr Ser Pro 265 270 275 acc agc att ctg gac ata aga caa gga cca aag gaa ccc ttt aga gac 1818 Thr Ser Ile Leu Asp Ile Arg Gln Gly Pro Lys Glu Pro Phe Arg Asp 280 285 290 295 tat gta gac cgg ttc tat aaa act cta aga gct gag caa gct tca cag 1866 Tyr Val Asp Arg Phe Tyr Lys Thr Leu Arg Ala Glu Gln Ala Ser Gln 300 305 310 gag gta aaa aat tgg atg aca gaa acc ttg ttg gtc caa aat gcg aac 1914 Glu Val Lys Asn Trp Met Thr Glu Thr Leu Leu Val Gln Asn Ala Asn 315 320 325 cca gat tgt aag acc atc ctg aag gct ctc ggc cca gcg gct aca cta 1962 Pro Asp Cys Lys Thr Ile Leu Lys Ala Leu Gly Pro Ala Ala Thr Leu 330 335 340 gaa gaa atg atg aca gca tgt cag gga gta gga gga ccc ggc cat aag 2010 Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly Pro Gly His Lys 345 350 355 gca aga gtt ttg tag ggatccacta gttctagact cgaggggggg cccggtacct 2065 Ala Arg Val Leu 360 ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg 2125 ggactggaag ggctaattca ctcccaaaga agacaagata aaccgctgat cagcctcgac 2185 tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct 2245 ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct 2305 gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg 2365 ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag 2425 aaccagcaga tctgcagatc tgaattcatc tatgtcgggt gcggagaaag aggtaatgaa 2485 atggcattat gggtattatg ggtctgcatt aatgaatcgg ccaacgcgcg gggagaggcg 2545 gtttgcgtat tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc 2605 ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag 2665 gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa 2725 aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc 2785 gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc 2845 ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg 2905 cctttctccc ttcgggaagc gtggcgcttt ctcaatgctc acgctgtagg tatctcagtt 2965 cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc 3025 gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc 3085 cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag 3145 agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg 3205 ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa 3265 ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag 3325 gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact 3385 cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttga 3445 tcctccggcg ttcagcctgt gccacagccg acaggatggt gaccaccatt tgccccatat 3505 caccgtcggt actgatcccg tcgtcaataa accgaaccgc tacaccctga gcatcaaact 3565 cttttatcag ttggatcatg tcggcggtgt cgcggccaag acggtcgagc ttcttcacca 3625 gaatgacatc accttcctcc accttcatcc tcagcaaatc cagcccttcc cgatctgttg 3685 aactgccgga tgccttgtcg gtaaagatgc ggttagcttt tacccctgca tctttgagcg 3745 ctgaggtctg cctcgtgaag aaggtgttgc tgactcatac caggcctgaa tcgccccatc 3805 atccagccag aaagtgaggg agccacggtt gatgagagct ttgttgtagg tggaccagtt 3865 ggtgattttg aacttttgct ttgccacgga acggtctgcg ttgtcgggaa gatgcgtgat 3925 ctgatccttc aactcagcaa aagttcgatt tattcaacaa agccgccgtc ccgtcaagtc 3985 agcgtaatgc tctgccagtg ttacaaccaa ttaaccaatt ctgattagaa aaactcatcg 4045 agcatcaaat gaaactgcaa tttattcata tcaggattat caataccata tttttgaaaa 4105 agccgtttct gtaatgaagg agaaaactca ccgaggcagt tccataggat ggcaagatcc 4165 tggtatcggt ctgcgattcc gactcgtcca acatcaatac aacctattaa tttcccctcg 4225 tcaaaaataa ggttatcaag tgagaaatca ccatgagtga cgactgaatc cggtgagaat 4285 ggcaaaagct tatgcatttc tttccagact tgttcaacag gccagccatt acgctcgtca 4345 tcaaaatcac tcgcatcaac caaaccgtta ttcattcgtg attgcgcctg agcgagacga 4405 aatacgcgat cgctgttaaa aggacaatta caaacaggaa tcgaatgcaa ccggcgcagg 4465 aacactgcca gcgcatcaac aatattttca cctgaatcag gatattcttc taatacctgg 4525 aatgctgttt tcccggggat cgcagtggtg agtaaccatg catcatcagg agtacggata 4585 aaatgcttga tggtcggaag aggcataaat tccgtcagcc agtttagtct gaccatctca 4645 tctgtaacat cattggcaac gctacctttg ccatgtttca gaaacaactc tggcgcatcg 4705 ggcttcccat acaatcgata gattgtcgca cctgattgcc cgacattatc gcgagcccat 4765 ttatacccat ataaatcagc atccatgttg gaatttaatc gcggcctcga gcaagacgtt 4825 tcccgttgaa tatggctcat aacacccctt gtattactgt ttatgtaagc agacagtttt 4885 attgttcatg atgatatatt tttatcttgt gcaatgtaac atcagagatt ttgagacaca 4945 acgtggcttt gttgaataaa tcgaactttt gctgagttga aggatcagat cacgcatctt 5005 cccgacaacg cagaccgttc cgtggcaaag caaaagttca aaatcaccaa ctggtccacc 5065 tacaacaaag ctctcatcaa ccgtggctcc ctcactttct ggctggatga tggggcgatt 5125 caggcctggt atgagtcagc aacaccttct tcacgaggca gacctcagcg ctagattatt 5185 gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa 5245 ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac gttaactata 5305 acggtcctaa 5315 <210> 199 <211> 363 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 199 Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 1 5 10 15 Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 20 25 30 His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 35 40 45 Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 50 55 60 Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 65 70 75 80 Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 85 90 95 Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 100 105 110 Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val 115 120 125 Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 130 135 140 Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 145 150 155 160 Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 165 170 175 Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 180 185 190 Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 195 200 205 Ala Ala Asp Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 210 215 220 Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 225 230 235 240 Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 245 250 255 Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 260 265 270 Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 275 280 285 Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 290 295 300 Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 305 310 315 320 Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 325 330 335 Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 340 345 350 Val Gly Gly Pro Gly His Lys Ala Arg Val Leu 355 360 <210> 200 <211> 26 <212> DNA <213> Artificial Sequence <220> <223> pSh-HIV-short-gag - based on HIV <220> <221> misc_feature <222> (1)..(26) <223> I-Ceu\I\Recognition\Sequence (5298...8) <400> 200 taactataac ggtcctaagg tagcga 26 <210> 201 <211> 2128 <212> DNA <213> Artificial Sequence <220> <223> pSR5 - based on E. coli <220> <221> misc_feature <222> (303)..(891) <223> pMB origin of replication <220> <221> rep_origin <222> (304)..(304) <223> ORI <220> <221> misc_feature <222> (1062)..(1925) <223> AP(R) complement (1062..1925) <400> 201 aattatttaa atcccgggga tcatcgatga tctctagaga tcactagtct aggatatcat 60 ttaaatatgc ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg catcaggcgc 120 tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta 180 tcagctcact caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag 240 aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg 300 tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg 360 tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg 420 cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga 480 agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc 540 tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt 600 aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact 660 ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg 720 cctaactacg gctacactag aaggacagta tttggtatct gcgctctgct gaagccagtt 780 accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt 840 ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct 900 ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg 960 gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt 1020 aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt 1080 gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc 1140 gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg 1200 cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc 1260 gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg 1320 gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctgca 1380 ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga 1440 tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct 1500 ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg 1560 cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca 1620 accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaaca 1680 cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct 1740 tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact 1800 cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa 1860 acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc 1920 atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga 1980 tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga 2040 aaagtgccac ctgacgtcta agaaaccatt attatcatga cattaaccta taaaaatagg 2100 cgtatcacga ggccctttcg tcttcaag 2128 <210> 202 <211> 2171 <212> DNA <213> Artificial Sequence <220> <223> pSR7 - based on E. coli <220> <221> misc_feature <222> (346)..(934) <223> pMB1\ori <220> <221> rep_origin <222> (347)..(347) <223> ORI <220> <221> misc_feature <222> (1105)..(1968) <223> AP(R) complement (1105..1968) <400> 202 aattgtttaa actacgtaat taggccggcc gcgcacgcgc atatggatcg atcgctagcg 60 atcgatcgaa ttccgcgtgt cattaattaa gctagatatc gtttaaacta tgcggtgtga 120 aataccgcac agatgcgtaa ggagaaaata ccgcatcagg cgctcttccg cttcctcgct 180 cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc 240 ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg 300 ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg 360 cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg 420 actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac 480 cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca 540 tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt 600 gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc 660 caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag 720 agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac 780 tagaaggaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt 840 tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa 900 gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg 960 gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa 1020 aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat 1080 atatgagtaa acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc 1140 gatctgtcta tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat 1200 acgggagggc ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc 1260 ggctccagat ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc 1320 tgcaacttta tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag 1380 ttcgccagtt aatagtttgc gcaacgttgt tgccattgct gcaggcatcg tggtgtcacg 1440 ctcgtcgttt ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg 1500 atcccccatg ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag 1560 taagttggcc gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt 1620 catgccatcc gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga 1680 atagtgtatg cggcgaccga gttgctcttg cccggcgtca acacgggata ataccgcgcc 1740 acatagcaga actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc 1800 aaggatctta ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc 1860 ttcagcatct tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc 1920 cgcaaaaaag ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca 1980 atattattga agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat 2040 ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgacgt 2100 ctaagaaacc attattatca tgacattaac ctataaaaat aggcgtatca cgaggccctt 2160 tcgtcttcaa g 2171 <210> 203 <211> 3615 <212> DNA <213> Artificial Sequence <220> <223> pBleuSK I-PI cassette - based on E. coli <220> <221> CDS <222> (818)..(1678) <223> Amp-R <220> <221> polyA_signal <222> (3254)..(3456) <223> BGH-polyA <400> 203 tatcgatacc gtcgacctcg agggggggcc cggtacccaa ttcgccctat agtgagtcgt 60 attacgcgcg ctcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta 120 cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg 180 cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg gacgcgccct 240 gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg 300 ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg 360 gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac 420 ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct 480 gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt 540 tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt 600 tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt 660 ttaacaaaat attaacgctt acaatttagg tggcactttt cggggaaatg tgcgcggaac 720 ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc 780 ctgataaatg cttcaataat attgaaaaag gaagagt atg agt att caa cat ttc 835 Met Ser Ile Gln His Phe 1 5 cgt gtc gcc ctt att ccc ttt ttt gcg gca ttt tgc ctt cct gtt ttt 883 Arg Val Ala Leu Ile Pro Phe Phe Ala Ala Phe Cys Leu Pro Val Phe 10 15 20 gct cac cca gaa acg ctg gtg aaa gta aaa gat gct gaa gat cag ttg 931 Ala His Pro Glu Thr Leu Val Lys Val Lys Asp Ala Glu Asp Gln Leu 25 30 35 ggt gca cga gtg ggt tac atc gaa ctg gat ctc aac agc ggt aag atc 979 Gly Ala Arg Val Gly Tyr Ile Glu Leu Asp Leu Asn Ser Gly Lys Ile 40 45 50 ctt gag agt ttt cgc ccc gaa gaa cgt ttt cca atg atg agc act ttt 1027 Leu Glu Ser Phe Arg Pro Glu Glu Arg Phe Pro Met Met Ser Thr Phe 55 60 65 70 aaa gtt ctg cta tgt ggc gcg gta tta tcc cgt att gac gcc ggg caa 1075 Lys Val Leu Leu Cys Gly Ala Val Leu Ser Arg Ile Asp Ala Gly Gln 75 80 85 gag caa ctc ggt cgc cgc ata cac tat tct cag aat gac ttg gtt gag 1123 Glu Gln Leu Gly Arg Arg Ile His Tyr Ser Gln Asn Asp Leu Val Glu 90 95 100 tac tca cca gtc aca gaa aag cat ctt acg gat ggc atg aca gta aga 1171 Tyr Ser Pro Val Thr Glu Lys His Leu Thr Asp Gly Met Thr Val Arg 105 110 115 gaa tta tgc agt gct gcc ata acc atg agt gat aac act gcg gcc aac 1219 Glu Leu Cys Ser Ala Ala Ile Thr Met Ser Asp Asn Thr Ala Ala Asn 120 125 130 tta ctt ctg aca acg atc gga gga ccg aag gag cta acc gct ttt ttg 1267 Leu Leu Leu Thr Thr Ile Gly Gly Pro Lys Glu Leu Thr Ala Phe Leu 135 140 145 150 cac aac atg ggg gat cat gta act cgc ctt gat cgt tgg gaa ccg gag 1315 His Asn Met Gly Asp His Val Thr Arg Leu Asp Arg Trp Glu Pro Glu 155 160 165 ctg aat gaa gcc ata cca aac gac gag cgt gac acc acg atg cct gta 1363 Leu Asn Glu Ala Ile Pro Asn Asp Glu Arg Asp Thr Thr Met Pro Val 170 175 180 gca atg gca aca acg ttg cgc aaa cta tta act ggc gaa cta ctt act 1411 Ala Met Ala Thr Thr Leu Arg Lys Leu Leu Thr Gly Glu Leu Leu Thr 185 190 195 cta gct tcc cgg caa caa tta ata gac tgg atg gag gcg gat aaa gtt 1459 Leu Ala Ser Arg Gln Gln Leu Ile Asp Trp Met Glu Ala Asp Lys Val 200 205 210 gca gga cca ctt ctg cgc tcg gcc ctt ccg gct ggc tgg ttt att gct 1507 Ala Gly Pro Leu Leu Arg Ser Ala Leu Pro Ala Gly Trp Phe Ile Ala 215 220 225 230 gat aaa tct gga gcc ggt gag cgt ggg tct cgc ggt atc att gca gca 1555 Asp Lys Ser Gly Ala Gly Glu Arg Gly Ser Arg Gly Ile Ile Ala Ala 235 240 245 ctg ggg cca gat ggt aag ccc tcc cgt atc gta gtt atc tac acg acg 1603 Leu Gly Pro Asp Gly Lys Pro Ser Arg Ile Val Val Ile Tyr Thr Thr 250 255 260 ggg agt cag gca act atg gat gaa cga aat aga cag atc gct gag ata 1651 Gly Ser Gln Ala Thr Met Asp Glu Arg Asn Arg Gln Ile Ala Glu Ile 265 270 275 ggt gcc tca ctg att aag cat tgg taa ctgtcagacc aagtttactc 1698 Gly Ala Ser Leu Ile Lys His Trp 280 285 atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat 1758 cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc 1818 agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg 1878 ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct 1938 accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa atactgtcct 1998 tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct 2058 cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg 2118 gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc 2178 gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga 2238 gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg 2298 cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta 2358 tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg 2418 ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg 2478 ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat 2538 taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc 2598 agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg cgcgttggcc 2658 gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa 2718 cgcaattaat gtgagttagc tcactcatta ggcaccccag gctttacact ttatgcttcc 2778 ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa acagctatga 2838 ccatgattac gccaagcgcg caattaaccc tcactaaagg gaacaaaagc tggagctcca 2898 ccgcggtggc ggccgctcta gaactagtgg atcccccggg ctgcaggaat tcgatatcat 2958 ttccccgaaa agtgccacct gacgtaacta taacggtcct aaggtagcga aagctcagat 3018 ctcccgatcc cctatggtgc actctcagta caatctgctc tgatgccgca tagttaagcc 3078 agtatctgct ccctgcttgt gtgttggagg tcgctgagta gtgcgcgagc aaaatttaag 3138 ctacaacaag gcaaggcttg accgacaatt gcatgaagaa tctgcttagg gttaggcgtt 3198 ttgcgctgct tcgcgatgta cgggccagat atacgcggta cgaaaccgct gatcagcctc 3258 gactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac 3318 cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg 3378 tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga 3438 ttgggaagac aatagcaggc atgctgggga tgcggtgggc tctatggctt ctgaggcgga 3498 aagaaccagc agatctgcag atctgaattc atctatgtcg ggtgcggaga aagaggtaat 3558 gaaatggcat tatgggtatt atgggtctgc attaatgaat cggccagata tcaagct 3615 <210> 204 <211> 286 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 204 Met Ser Ile Gln His Phe Arg Val Ala Leu Ile Pro Phe Phe Ala Ala 1 5 10 15 Phe Cys Leu Pro Val Phe Ala His Pro Glu Thr Leu Val Lys Val Lys 20 25 30 Asp Ala Glu Asp Gln Leu Gly Ala Arg Val Gly Tyr Ile Glu Leu Asp 35 40 45 Leu Asn Ser Gly Lys Ile Leu Glu Ser Phe Arg Pro Glu Glu Arg Phe 50 55 60 Pro Met Met Ser Thr Phe Lys Val Leu Leu Cys Gly Ala Val Leu Ser 65 70 75 80 Arg Ile Asp Ala Gly Gln Glu Gln Leu Gly Arg Arg Ile His Tyr Ser 85 90 95 Gln Asn Asp Leu Val Glu Tyr Ser Pro Val Thr Glu Lys His Leu Thr 100 105 110 Asp Gly Met Thr Val Arg Glu Leu Cys Ser Ala Ala Ile Thr Met Ser 115 120 125 Asp Asn Thr Ala Ala Asn Leu Leu Leu Thr Thr Ile Gly Gly Pro Lys 130 135 140 Glu Leu Thr Ala Phe Leu His Asn Met Gly Asp His Val Thr Arg Leu 145 150 155 160 Asp Arg Trp Glu Pro Glu Leu Asn Glu Ala Ile Pro Asn Asp Glu Arg 165 170 175 Asp Thr Thr Met Pro Val Ala Met Ala Thr Thr Leu Arg Lys Leu Leu 180 185 190 Thr Gly Glu Leu Leu Thr Leu Ala Ser Arg Gln Gln Leu Ile Asp Trp 195 200 205 Met Glu Ala Asp Lys Val Ala Gly Pro Leu Leu Arg Ser Ala Leu Pro 210 215 220 Ala Gly Trp Phe Ile Ala Asp Lys Ser Gly Ala Gly Glu Arg Gly Ser 225 230 235 240 Arg Gly Ile Ile Ala Ala Leu Gly Pro Asp Gly Lys Pro Ser Arg Ile 245 250 255 Val Val Ile Tyr Thr Thr Gly Ser Gln Ala Thr Met Asp Glu Arg Asn 260 265 270 Arg Gln Ile Ala Glu Ile Gly Ala Ser Leu Ile Lys His Trp 275 280 285 <210> 205 <211> 89 <212> DNA <213> Artificial Sequence <220> <223> ICeuPISceI cassette based on Saccharomyces cerevisiae <220> <221> misc_feature <222> (13)..(38) <223> I-Ceu recognition site <220> <221> misc_feature <222> (26)..(27) <223> cleavage point for bottom strand <220> <221> misc_feature <222> (30)..(31) <223> cleavage point for top strand <220> <221> misc_feature <222> (39)..(77) <223> PI-SceI recognition sequence <220> <221> misc_feature <222> (49)..(50) <223> cleavage point on bottom strand <220> <221> misc_feature <222> (53)..(54) <223> cleavage point on top strand <400> 205 gatcatcgta cgtaactata acggtcctaa ggtagcgaat ctatgtcggg tgcggagaaa 60 gaggtaatga aatggcacat atggatcta 89 <210> 206 <211> 36773 <212> DNA <213> Artificial Sequence <220> <223> p2870 - E1 deleted molecular clone, based on Simian Adenovirus A1320 <220> <221> repeat_region <222> (1)..(129) <223> ITR <220> <221> polyA_signal <222> (755)..(957) <223> BGH-PolyA (bovine growth hormone (bGH) polyadenylation signal) <220> <221> misc_feature <222> (1111)..(1496) <223> E1b\del <220> <221> misc_feature <222> (2070)..(3691) <223> IVa2 complement (2070..3691) <220> <221> misc_feature <222> (3680)..(11945) <223> pol complement (3680..11945) <220> <221> misc_feature <222> (6550)..(11945) <223> pTP complement (6550..11945) <220> <221> CDS <222> (10142)..(11902) <223> pIIIa <220> <221> CDS <222> (11985)..(13610) <223> penton <220> <221> CDS <222> (13617)..(14198) <223> pVIII <220> <221> CDS <222> (14246)..(15289) <223> V <220> <221> CDS <222> (15317)..(15547) <223> pX <220> <221> CDS <222> (15620)..(16351) <223> pVI <220> <221> CDS <222> (16458)..(19286) <223> hexon <220> <221> CDS <222> (19308)..(19931) <223> protease <220> <221> CDS <222> (20016)..(21551) <223> DBP complement (20016..21551) <220> <221> CDS <222> (21580)..(23973) <223> 100K <220> <221> CDS <222> (24599)..(25279) <223> pVIII <220> <221> CDS <222> (25283)..(25600) <223> E3 12.5K <220> <221> CDS <222> (26162)..(26689) <223> E3 gp19K <220> <221> CDS <222> (26722)..(27321) <223> E3 CR1-beta <220> <221> CDS <222> (27338)..(27949) <223> E3 CR1-gamma <220> <221> CDS <222> (29134)..(29562) <223> E3 RID-beta <220> <221> CDS <222> (30259)..(31593) <223> fiber <220> <221> misc_feature <222> (31686)..(33019) <223> E4 orf 6/7 complement (31686..31936, 32669..33019) <220> <221> misc_feature <222> (32669)..(32692) <223> middle\right <220> <221> CDS <222> (32748)..(33110) <223> E4 orf4 complement (32748..33110) <220> <221> repeat_region <222> (34556)..(34684) <223> ITR complement (34556..34684) <220> <221> misc_feature <222> (34924)..(34930) <223> pMB1\ORI: low copy number <220> <221> misc_feature <222> (34933)..(35521) <223> pMB1\ori <220> <221> rep_origin <222> (34934)..(34934) <223> ORI <220> <221> CDS <222> (35692)..(36555) <223> AP(R) [Note: E-286] Complement (35692..36555) <400> 206 catcatcaat aatatacctc aaactttttg tgcgcgttaa tatgcaaatg aggcgtttga 60 atttggggat gcggggcggt gattggctgt gggaaaggcg accgttaggg gcggggcggg 120 tgacgttttg atgacgtgtt tgtgaggcgg agccggtttg caagttctcg tgggaaaagt 180 gacgtcaaac gaggtgtggt ttgaacacgg aaatactcaa ttttcccgcg ctctctgaca 240 ggaaatgagg tgtttctggg cggatgcaag tgaaaacggg ccattttcgc gcgaaaactg 300 aatgaggaag tgaaaatctg agtaatttcg cgtttatggc agggaggagt atttgccgag 360 ggccgagtag actttgaccg attacgtggg ggtttcgatt accgtgtttt tcacctaaat 420 ttccgcgtac ggtgtcaaag tccggtgttt ttacatcatt tccccgaaaa gtgccacctg 480 acgtaactat aacggtccta aggtagcgaa agctcagatc tcccgatccc ctatggtgca 540 ctctcagtac aatctgctct gatgccgcat agttaagcca gtatctgctc cctgcttgtg 600 tgttggaggt cgctgagtag tgcgcgagca aaatttaagc tacaacaagg caaggcttga 660 ccgacaattg catgaagaat ctgcttaggg ttaggcgttt tgcgctgctt cgcgatgtac 720 gggccagata tacgcggtac gaaaccgctg atcagcctcg actgtgcctt ctagttgcca 780 gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac 840 tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat 900 tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca 960 tgctggggat gcggtgggct ctatggcttc tgaggcggaa agaaccagca gatctgcaga 1020 tctgaattca tctatgtcgg gtgcggagaa agaggtaatg aaatggcatt atgggtatta 1080 tgggtctgca ttaatgaatc ggccagatta tgctggccac cgtgcatgtg gcctcgcacc 1140 cccgcaagac atggcccgag ttcgagcaca acgtcatgac ccgctgcaat gtgcacctgg 1200 gctcccgccg aggcatgttc atgccatacc agtgcaacat gcaatttgtg aaggtgctgc 1260 tggagcccga tgccatgtcc agagtgagcc tgacgggggt gtttgacatg aatgtggagc 1320 tgtggaaaat tctgagatat gatgaatcca agaccaggtg ccgggcctgc gaatgcggag 1380 gcaagcacgc caggcttcag cccgtgtgtg tggaggtgac ggaggacctg cgacccgatc 1440 atttggtgtt gtcctgcaac gggacggagt tcggctccag cggggaagaa tctgactaga 1500 gtgagtagtg tttgggggtg ggtgggagcc tgcatgatgg gcagaatgac taaaatctgt 1560 gtttttctgc gcagcagcat gagcggaagc gcctcctttg agggaggggt attcagccct 1620 tatctgacgg ggcgtctccc ctcctgggct ggagtgcgtc agaatgtgat gggatccacg 1680 gtggacggcc ggcccgtgca gcccgcgaac tcttcaaccc tgacctacgc gaccctgagc 1740 tcctcgtccg tggacgcagc tgccgccgca gctgctgctt ccgccgccag cgccgtgcgc 1800 ggaatggccc tgggtgccgg ctactacagc tctctggtgg ccaactcgag ttccgccaat 1860 aatcccgcca gcctgaacga ggagaagctg ctgctgctga tggcccagct cgaggccctg 1920 acccagcgcc tgggcgagct gacccagcag gtggctcagc tgcaggcgga gacgcgggcc 1980 gcggttgcca cggtgaaaac caaataaaaa atgaatcaat aaataaacgg aaacggttgt 2040 tgattttaac acagagtctt gaatctttat ttgatttttc gcgcgcggta ggccctggac 2100 caccggtctc gatcattgag cacccggtgg atcttttcca ggacccggta gaggtgggct 2160 tggatgttga ggtacatggg catgagcccg tcccgggggt ggaggtagct ccactgcagg 2220 gcctcgtgct cgggggtggt gttgtaaatc acccagtcat agcaggggcg cagggcgtgg 2280 tgctgcacga tgtccttgag gaggagactg atggccacgg gcagtccctt ggtgtaggtg 2340 ttgacgaacc tgttgagctg ggagggatgc atgcgggggg agatgagatg catcttggcc 2400 tggatcttga gattggcgat gttcccaccc agatcccgcc gggggttcat gttgtgcagg 2460 accaccagca cggtgtatcc ggtgcacttg gggaatttgt catgcaactt ggaagggaag 2520 gcgtgaaaga atttggagac gcccttgtga ccgcccaggt tttccatgca ctcatccatg 2580 atgatggcga tgggcccgtg ggcggcggcc tgggcaaaga cgtttcgggg gtcggacaca 2640 tcgtagttgt ggtcctgggt gagctcgtca taggccattt taatgaattt ggggcggagg 2700 gtgcccgact gggggacaaa ggtgccctcg atcccggggg cgtagttgcc ctcgcagatc 2760 tgcatctccc aggccttgag ctcggagggg gggatcatgt ccacctgcgg ggcgatgaaa 2820 aaaacggttt ccggggcggg ggagatgagc tgggccgaaa gcaggttccg gagcagctgg 2880 gacttgccgc agccggtggg gccgtagatg accccgatga ccggctgcag gtggtagttg 2940 agggagagac agctgccgtc ctcgcggagg aggggggcca cctcgttcat catctcgcgc 3000 acatgcatgt tctcgcgcac gagttccgcc aggaggcgct cgccccccag cgagaggagc 3060 tcttgcagcg aggcgaagtt tttcagcggc ttgagtccgt cggccatggg cattttggag 3120 agggtctgtt gcaagagttc cagacggtcc cagagctcgg tgatgtgctc tagggcatct 3180 cgatccagca gacctcctcg tttcgcgggt tggggcggct gcgggagtag ggcaccaggc 3240 gatgggcgtc cagcgaggcc agggtccggt ccttccaggg tcgcagggtc cgcgtcagcg 3300 tggtctccgt cacggtgaag gggtgcgcgc cgggctgggc gcttgcgagg gtgcgcttca 3360 ggctcatccg gctggtcgag aaccgctccc ggtcggtgcc ctgcgcgtcg gccaggtagc 3420 aattgagcat gagttcgtag ttgagcgcct cggccgcgtg gcccttggcg cggagcttac 3480 ctttggaagt gtgtccgcag acgggacaga ggagggactt gagggcgtag agcttggggg 3540 cgaggaagac ggactcgggg gcgtaggcgt ccgcgccgca gctggcgcag acggtctcgc 3600 actccacgag ccaggtgagg tcggggcggt cggggtcaaa aacgaggttt cctccgtgct 3660 ttttgatgcg tttcttacct ctggtctcca tgagctcgtg tccccgctgg gtgacaaaga 3720 ggctgtccgt gtccccgtag accgacttta tgggccggtc ctcgagcggg gtgccgcggt 3780 cctcgtcgta gaggaacccc gcccactccg agacgaaggc ccgggtccag gccagcacga 3840 aggaggccac gtgggagggg tagcggtcgt tgtccaccag cgggtccacc ttctccaggg 3900 tatgcaagca catgtccccc tcgtccacat ccaggaaggt gattggcttg taagtgtagg 3960 ccacgtgacc gggggtcccg gccggggggg tataaaaggg ggcgggcccc tgctcgtcct 4020 cactgtcttc cggatcgctg tccaggagcg ccagctgttg gggtaggtat tccctctcga 4080 aggcgggcat gacctcggca ctcaggttgt cagtttctag aaacgaggag gatttgatat 4140 tgacggtgcc gttggagacg cctttcatga gcccctcgtc catctggtca gaaaagacga 4200 tctttttgtt gtcgagcttg gtggcgaagg agccgtagag ggcattggag aggagcttgg 4260 cgatggagcg catggtctgg ttcttttcct tgtcggcgcg ctccttggcg gcgatgttga 4320 gctgcacgta ctcgcgcgcc acgcacttcc attcggggaa gacggtggtg agctcgtcgg 4380 gcacgattct gacccgccag ccgcggttgt gcagggtgat gaggtccacg ctggtggcca 4440 cctcgccgcg caggggctcg ttggtccagc agaggcgccc gcccttgcgc gagcagaagg 4500 ggggcagcgg gtccagcatg agctcgtcgg gggggtcggc gtccacggtg aagatgccgg 4560 gcaggagctc ggggtcgaag tagctgatgc aggtgcccag atcgtccagc gccgcttgcc 4620 agtcgcgcac ggccagcgcg cgctcgtagg ggctgagggg cgtgccccag ggcatggggt 4680 gcgtgagcgc ggaggcgtac atgccgcaga tgtcgtagac gtagaggggc tcctcgagga 4740 cgccgatgta ggtggggtag cagcgccccc cgcggatgct ggcgcgcacg tagtcgtaca 4800 gctcgtgcga gggcgcgagg agccccgcgc cgaggttgga gcgctgcggc ttttcggcgc 4860 ggtagacgat ctggcggaag atggcgtggg agttggagga gatggtgggc ctctggaaga 4920 tgttgaagtg ggcgtggggc aggccgaccg agtccctgat gaagtgggcg taggagtcct 4980 gcagcttggc gacgagctcg gcggtgacga ggacgtccag ggcgcagtag tcgagggtct 5040 cttggatgat gtcgtacttg agctggccct tctgcttcca cagctcgcgg ttgagaagga 5100 actcttcgcg gtccttccag tactcttcga gggggaaccc gtcctgatcg gcacggtaag 5160 agcccaccat gtagaactgg ttgacggcct tgtaggcgca gcagcccttc tccacgggga 5220 gggcataagc ttgcgcggcc ttgcgcaggg aggtgtgggt gagggcgaag gtgtcgcgca 5280 ccatgacctt gaggaactgg tgcttgaagt cgaggtcgtc gcagccgccc tgctcccaga 5340 gttggaagtc cgtgcgcttc ttgtaggcgg ggttgggcaa agcgaaagta acatcgttga 5400 agaggatctt gcccgcgcgg ggcatgaagt tgcgagtgat gcggaaaggc tggggcacct 5460 cggcccggtt gttgatgacc tgggcggcga ggacgatctc gtcgaagccg ttgatgttgt 5520 gcccgacgat gtagagttcc acgaatcgcg ggcggccctt gacgtggggc agcttcttga 5580 gctcgtcgta ggtgagctcg gcggggtcgc tgagtccgtg ctgctcaagg gcccagtcgg 5640 cgacgtgggg gttggcgctg aggaaggaag tccagagatc cacggccagg gcggtttgca 5700 agcggtcccg gtactgacgg aactgctggc ccacggccat tttttcgggg gtgatgcagt 5760 agaaggtgcg ggggtcgccg tgccagcggt cccacttgag ctggagggcg aggtcgtggg 5820 cgagctcgac aagcggcggg tccccggaga gtttcatgac cagcatgaag gggacgagct 5880 gcttgccgaa ggaccccatc caggtgtagg tttccacatc gtaggtgagg aagagccttt 5940 cggtgcgagg atgcgagccg atggggaaga actggatctc ctgccaccag ttggaggaat 6000 ggctgttgat gtgatggaag tagaaatgcc gacggcgcgc cgagcactcg tgcttgtgtt 6060 tatacaagcg tccgcagtgc tcgcaacgct gcacgggatg cacgtgctgc acgagctgta 6120 cctgagttcc tttgacgagg aatttcagtg ggcagtggag cgctggcggc tgcatctggt 6180 gctgtactac gtcctggcca tcggcgtggc catcgtctgc ctcgatggtg gtcatgctga 6240 cgagcccgcg cgggaggcag gtccagacct cggctcggac gggtcggaga gcgaggacga 6300 gggcgcgcag gccggagctg tccagggtcc tgagacgctg cggagtcagg tcagtgggca 6360 gcggcggcgc gcggttgact tgcaggagct tttccagggc gcgcgggagg tccagatggt 6420 acttgatctc cacggcgccg ttggtggcga cgtccacggc ttgcagggtc ccgtgcccct 6480 ggggcgccac caccgtgccc cgtttcttct tgggcgctgg cggcgttggc gctggttcca 6540 tgtcggtcag aagcggcggc gaggacgcgc gccgggcggc aggggcggct cggggcccgg 6600 aggcaggggc ggcaggggca cgtcggcgcc gcgcgcgggc aggttctggt actgcgcccg 6660 gagaagactg gcgtgagcga cgacgcgacg gttgacgtcc tggatctgac gcctctgggt 6720 gaaggccacg ggacccgtga gtttgaacct gaaagagagt tcgacagaat caatctcggt 6780 atcgttgacg gcggcctgcc gcaggatctc ttgcacgtcg cccgagttgt cctggtaggc 6840 gatctcggtc atgaactgct cgatctcctc ctcctgaagg tctccgcggc cggcgcgctc 6900 gacggtggcc gcgaggtcgt tggagatgcg ggccatgagc tgcgagaagg cgttcatgcc 6960 ggcctcgttc cagacgcggc tgtagaccac ggctccgtcg gggtcgcgcg cgcgcatgac 7020 cacctgggca aggttgagct cgacgtggcg cgtgaagacc gcgtagttgc agaggcgctg 7080 gtagaggtag ttgagcgtgg tggcgatgtg ctcggtgacg aagaagtaca tgatccagcg 7140 gcggagcggc atctcgctga cgtcgcccag ggcttccaag cgctccatgg cctcgtagaa 7200 gtccacggcg aagttgaaaa actgggagtt gcgcgccgag acggtcaact cctcctccag 7260 aagacggatg agctctgcga tggtggcgcg cacctcgcgc tcgaaggccc cggggggctc 7320 ctcttcttcc atctcctcct cctcttcctc ctccactaac atctcttcta cttcctcctc 7380 aggcggtggt ggcgggggag ggggcctgcg tcgccggcgg cgcacgggca gacggtcgat 7440 gaagcgctcg atggtctcgc cgcgccggcg tcgcatggtc tcggtgacgg cgcgcccgtc 7500 ctcgcggggc cgcagcgtga agacgccgcc gcgcatctcc aggtggccgg gggggtcccc 7560 gttgggcagg gagagggcgc tgacgatgca tcttatcaat tgccccgtag ggactccgcg 7620 caaggacctg agcgtctcga gatccacggg atctgaaaac cgttgaacga aggcttcgag 7680 ccagtcgcag tcgcaaggta ggctgagcac ggtttcttct ggcgggtcat gttggttgga 7740 gggagcgggg cgggcgatgc tgctggtgat gaagttgaaa taggcggttc tgagacggcg 7800 gatggtggcg aggagcacca ggtctttggg cccggcttgc tggatgcgca gacggtcggc 7860 catgccccag gcgtggtcct gacacctggc caggtccttg tagtagtcct gcatgagccg 7920 ctccacgggc acctcctcct cgcccgcgcg gccgtgcatg cgcgtgagcc cgaagccgcg 7980 ctggggctgg acgagcgcca ggtcggcgac gacgcgctcg gcgaggatgg cctgctggac 8040 ctgggtgagg gtggtctgga agtcgtcgaa gtcgacgaag cggtggtagg ctccggtgtt 8100 gatggtgtag gagcagttgg ccatgacgga ccagttgacg gtctggtggc cggggcgcac 8160 gagctcgtgg tacttgaggc gcgagtaggc gcgcgtgtcg aagatgtagt cgttgcaggt 8220 gcgcacgagg tactggtatc cgacgaggaa gtgcggcggc ggctggcggt agagcggcca 8280 tcgctcggtg gcgggggcgc cgggcgcgag gtcctcgagc atgaggcggt ggtagccgta 8340 gatgtacctg gacatccagg tgatgccggc ggcggtggtg gaggcgcgcg ggaactcgcg 8400 gacgcggttc cagatgttgc gcagcggcag gaagtagttc atggtggccg cggtctggcc 8460 cgtgaggcgc gcgcagtcgt ggatgctcta gacatacggg caaaaacgaa agcggtcagc 8520 ggctcgactc cgtggcctgg aggctaagcg aacgggttgg gctgcgcgtg taccccggtt 8580 cgagtctctg ctcgaatcag gctggagccg cagctaacgt ggtactggca ctcccgtctc 8640 gacccaagcc tgctaacgaa acctccagga tacggaggcg ggtcgttttt tggccttggt 8700 cactggtcat gaaaaactag taagcgcgga aagcggccgc ccgcgatggc tcgctgccgt 8760 agtctggaga aagaatcgcc agggttgcgt tgcggtgtgc cccggttcga gactcagcgc 8820 tcggcgccgg ccggattccg cggctaacgt gggcgtggct gccccgtcgt ttccaagacc 8880 ccttagccag ccgacttctc cagttacgga gcgagcccct ctttttcttg tgtttttgcc 8940 agatgcatcc cgtactgcgg cagatgcgcc cccaccctcc accacaaccg cccctaccgc 9000 cgcagcagca gcaacagccg gcgcttctgc ccccgcccca gcagcagcca gccactaccg 9060 cggcggccgc cgtgagcgga gccggcgttc agtatgacct ggccttggaa gagggcgagg 9120 ggctggcgcg gctgggggcg tcgtcgccgg agcggcaccc gcgcgtgcag atgaaaaggg 9180 acgctcgcga ggcctacgtg cccaagcaga acctgttcag agacaggagc ggcgaggagc 9240 ccgaggagat gcgcgcctcc cgcttccacg cggggcggga gctgcggcgc ggcctggacc 9300 gaaagcgggt gctgagggac gaggatttcg aggcggacga gctgacgggg atcagccccg 9360 cgcgcgcgca cgtggccgcg gccaacctgg tcacggcgta cgagcagacc gtgaaggagg 9420 agagcaactt ccaaaaatcc ttcaacaacc acgtgcgcac gctgatcgcg cgcgaggagg 9480 tgaccctggg cctgatgcat ctgtgggacc tgttggaggc catcgtgcag aaccccacga 9540 gcaagccgct gacggcgcag ctgtttctgg tggtgcagca cagtcgggac aacgagacgt 9600 tcagggaggc gctgctgaat atcaccgagc ccgagggccg ctggctcctg gacctggtga 9660 acattctgca gagcatcgtg gtgcaggagc gcgggctgcc gctgtccgag aagctggcgg 9720 ccatcaactt ctcggtgctg agcctgggca agtactacgc taggaagatc tacaagaccc 9780 cgtacgtgcc catagacaag gaggtgaaga tcgacgggtt ttacatgcgc atgaccctga 9840 aagtgctgac cctgagcgac gatctggggg tgtaccgcaa cgacaggatg caccgcgcgg 9900 tgagcgccag ccgccggcgc gagctgagcg accaggagct gatgcacagc ctgcagcggg 9960 ccctgaccgg ggccgggacc gagggggaga gctactttga catgggcgcg gacctgcgct 10020 ggcagcccag ccgccgggct ttagaggcag ccggcggcgt gccctacgtg gaggaggtgg 10080 acgatgatga ggaggagggc gagtacctgg aagactgatg gcgcgaccgt atttttgcta 10140 g atg cag caa cag cca ccg cct cct gat ccc gcg atg cgg gcg gcg ctg 10189 Met Gln Gln Gln Pro Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu 1 5 10 15 cag agc cag ccg tcc ggc att aac tcc tcg gac gat tgg acc cag gcc 10237 Gln Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala 20 25 30 atg caa cgc atc atg gcg ctg acg acc cgc aat ccc gaa gcc ttt aga 10285 Met Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg 35 40 45 cag cag cct cag gcc aac cgg ctc tcg gcc atc ctg gag gcc gtg gtg 10333 Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val 50 55 60 ccc tcg cgc tcg aac ccc acg cac gag aag gtg ctg gcc atc gtg aac 10381 Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn 65 70 75 80 gcg ctg gtg gag aac aag gcc atc cgc ggc gac gag gcc ggg ctg gtg 10429 Ala Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val 85 90 95 tac aac gcg ctg ctg gag cgc gtg gcc cgc tac aac agc acc aac gtg 10477 Tyr Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val 100 105 110 cag acg aac ctg gac cgc atg gtg acc gac gtg cgc gag gcg gtg tcg 10525 Gln Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ser 115 120 125 cag cgc gag cgg ttc cac cgc gag tcg aac ctg ggc tcc atg gtg gcg 10573 Gln Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala 130 135 140 ctg aac gcc ttc ctg agc acg cag ccc gcc aac gtg ccc cgg ggc cag 10621 Leu Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln 145 150 155 160 gag gac tac acc aac ttt atc agc gcg ctg cgg ctg atg gtg gcc gag 10669 Glu Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Ala Glu 165 170 175 gtg ccc cag agc gag gtg tac cag tcg ggg ccg gac tac ttc ttc cag 10717 Val Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln 180 185 190 acc agt cgc cag ggc ttg cag acc gtg aac ctg agc cag gct ttc aag 10765 Thr Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys 195 200 205 aac ttg cag gga ctg tgg ggc gtg cag gcc ccg gtc ggg gac cgc gcg 10813 Asn Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala 210 215 220 acg gtg tcg agc ctg ctg acg ccg aac tcg cgc ctg ctg ctg ctg ctg 10861 Thr Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu 225 230 235 240 gtg gcg ccc ttc acg gac agc ggc agc gtg agc cgc gac tcg tac ctg 10909 Val Ala Pro Phe Thr Asp Ser Gly Ser Val Ser Arg Asp Ser Tyr Leu 245 250 255 ggc tac ctg ctt aac ctg tac cgc gag gcc atc ggg cag gcg cac gtg 10957 Gly Tyr Leu Leu Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val 260 265 270 gac gag cag acc tac cag gag atc acc cac gtg agc cgc gcg ctg ggc 11005 Asp Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly 275 280 285 cag gag gac ccg ggc aac ctg gag gcc acc ctg aac ttc ctg ctg acc 11053 Gln Glu Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr 290 295 300 aac cgg tcg cag aag atc ccg ccc cag tac gcg ctg agc acc gag gag 11101 Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu 305 310 315 320 gag cgc atc ctg cgc tac gtg cag cag agc gtg ggg ctg ttc ctg atg 11149 Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met 325 330 335 cag gag ggg gcc acg ccc agc gcc gcg ctc gac atg acc gcg cgc aac 11197 Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn 340 345 350 atg gag ccc agc atg tac gcc cgc aac cgc ccg ttc atc aat aag ctg 11245 Met Glu Pro Ser Met Tyr Ala Arg Asn Arg Pro Phe Ile Asn Lys Leu 355 360 365 atg gac tac ttg cat cgg gcg gcc gcc atg aac tcg gac tac ttt acc 11293 Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr 370 375 380 aac gcc atc ttg aac ccg cac tgg ctc ccg ccg ccc ggg ttc tac acg 11341 Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr 385 390 395 400 ggc gag tac gac atg ccc gac ccc aac gac ggg ttc ctg tgg gac gac 11389 Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp 405 410 415 gtg gac agc agc gtg ttc tcg ccg cgc ccc acc acc acc gtg tgg aag 11437 Val Asp Ser Ser Val Phe Ser Pro Arg Pro Thr Thr Thr Val Trp Lys 420 425 430 aaa gag ggc ggg gac cgg cgg ccg tcc tcg gcg ctg tcc ggt cgc gcg 11485 Lys Glu Gly Gly Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly Arg Ala 435 440 445 ggt gct gcc gcg gcg gtg ccc gag gcc gcc agc ccc ttc ccg agc ctg 11533 Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu 450 455 460 ccc ttt tcg ctg aac agc gtg cgc agc agc gag ctg ggt cgg ctg acg 11581 Pro Phe Ser Leu Asn Ser Val Arg Ser Ser Glu Leu Gly Arg Leu Thr 465 470 475 480 cgg ccg cgc ctg ctg ggc gag gag gag tac ctg aac gac tcc ttg ttg 11629 Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu 485 490 495 agg ccc gag cgc gag aaa aac ttc ccc aat aac ggg ata gag agc ctg 11677 Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu 500 505 510 gtg gac aag atg agc cgc tgg aag acg tac gcg cac gag cac agg gac 11725 Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala His Glu His Arg Asp 515 520 525 gag ccc cga gct agc agc agc gcc ggc gcc acc cgt aga cgc cag cgg 11773 Glu Pro Arg Ala Ser Ser Ser Ala Gly Ala Thr Arg Arg Arg Gln Arg 530 535 540 cac gac agg cag cgg gga ctg gtg tgg gac gat gag gat tcc gcc gac 11821 His Asp Arg Gln Arg Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp 545 550 555 560 gac agc agc gtg ttg gac ttg ggt ggg agt ggt ggt ggt aac ccg ttc 11869 Asp Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe 565 570 575 gct cac ttg cgc ccc cgt atc ggg cgc ctg atg taagaatctg aaaaaataaa 11922 Ala His Leu Arg Pro Arg Ile Gly Arg Leu Met 580 585 aaaacggtac tcaccaaggc catggcgacc agcgtgcgtt cttctctgtt gtttgtagta 11982 gt atg atg agg cgc gtg tac ccg gag ggt cct cct ccc tcg tac gag 12029 Met Met Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu 590 595 600 agc gtg atg cag cag gcg gtg gcg gcg gcg atg cag ccc ccg ctg gag 12077 Ser Val Met Gln Gln Ala Val Ala Ala Ala Met Gln Pro Pro Leu Glu 605 610 615 gcg cct tac gtg ccc ccg cgg tac ctg gcg cct acg gag ggg cgg aac 12125 Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg Asn 620 625 630 agc att cgt tac tcg gag ctg gca ccc ttg tac gat acc acc cgg ttg 12173 Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg Leu 635 640 645 650 tac ctg gtg gac aac aag tcg gcg gac atc gcc tcg ctg aac tac cag 12221 Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr Gln 655 660 665 aac gac cac agc aac ttc ctg acc acc gtg gtg cag aac aac gat ttc 12269 Asn Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp Phe 670 675 680 acc ccc acg gag gcc agc acc cag acc atc aac ttt gac gag cgc tcg 12317 Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser 685 690 695 cgg tgg ggc ggc cag ctg aaa acc atc atg cac acc aac atg ccc aac 12365 Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro Asn 700 705 710 gtg aac gag ttc atg tac agc aac aag ttc aag gcg cgg gtg atg gtc 12413 Val Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val 715 720 725 730 tcg cgc aag acc ccc aac ggg gtg acg gtg gat gag aat tat gat ggt 12461 Ser Arg Lys Thr Pro Asn Gly Val Thr Val Asp Glu Asn Tyr Asp Gly 735 740 745 agt cag gac gag ctg acc tac gag tgg gtg gag ttt gag ctg ccc gag 12509 Ser Gln Asp Glu Leu Thr Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu 750 755 760 ggc aac ttc tcg gtg acc atg acc atc gat ctg atg aac aac gcc atc 12557 Gly Asn Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile 765 770 775 atc gac aac tac ttg gcg gtg gga cgg cag aac ggg gtg ctg gag agc 12605 Ile Asp Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser 780 785 790 gac atc ggc gtg aag ttc gac acg cgc aac ttc cgg ctg ggc tgg gac 12653 Asp Ile Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp 795 800 805 810 ccc gtg acc gag ctg gtg atg ccg ggc gtg tac acc aac gag gcc ttc 12701 Pro Val Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe 815 820 825 cac ccc gac atc gtc ctg ctg ccc ggc tgc ggc gtg gac ttc acc gag 12749 His Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu 830 835 840 agc cgc ctc agc aac ctg ctg ggc atc cgc aag cgg cag ccc ttc cag 12797 Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln 845 850 855 gag ggc ttc cag atc ctg tac gag gac ctg gag ggg ggc aac atc ccc 12845 Glu Gly Phe Gln Ile Leu Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro 860 865 870 gcg ctg ctg gac gtc gaa gcc tac gag aaa agc aag gag gag gcc gcc 12893 Ala Leu Leu Asp Val Glu Ala Tyr Glu Lys Ser Lys Glu Glu Ala Ala 875 880 885 890 gca gcg gcg acc gcg gcc gtg gct acc gct gcg acc acc gat gca gat 12941 Ala Ala Ala Thr Ala Ala Val Ala Thr Ala Ala Thr Thr Asp Ala Asp 895 900 905 gca gct act act acc agg ggc gat aca ttc gcc acc cag gcg gag gaa 12989 Ala Ala Thr Thr Thr Arg Gly Asp Thr Phe Ala Thr Gln Ala Glu Glu 910 915 920 gca gcc gcc cta gcg gcg acc gat gat agt gaa agt aag ata gtc atc 13037 Ala Ala Ala Leu Ala Ala Thr Asp Asp Ser Glu Ser Lys Ile Val Ile 925 930 935 aag ccg gtg gag aag gac agc aag gac agg agc tac aac gtt cta tcg 13085 Lys Pro Val Glu Lys Asp Ser Lys Asp Arg Ser Tyr Asn Val Leu Ser 940 945 950 gat gga aag aac acc gcc tac cgc agc tgg tac ctg gcc tac aac tac 13133 Asp Gly Lys Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr 955 960 965 970 ggc gac cct gag aag ggc gtg cgc tcc tgg acg ctg ctc acc acc tcg 13181 Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr Ser 975 980 985 gac gtc acc tgc ggc gtg gag caa gtc tac tgg tcg ctg ccc gac atg 13229 Asp Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser Leu Pro Asp Met 990 995 1000 atg caa gac ccg gtc acc ttc cgc tcc acg cgt caa gtt agc aac 13274 Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn 1005 1010 1015 tac ccg gtg gtg ggc gcc gag ctc ctg ccc gtc tac tcc aag agc 13319 Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser 1020 1025 1030 ttc ttc aac gag cag gcc gtc tac tcg cag cag ctg cgc gcc ttc 13364 Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Ala Phe 1035 1040 1045 acc tcg ctc acg cac gtc ttc aac cgc ttc ccc gag aac cag atc 13409 Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile 1050 1055 1060 ctc gtc cgc ccg ccc gcg ccc acc att acc acc gtc agt gaa aac 13454 Leu Val Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn 1065 1070 1075 gtt cct gct ctc aca gat cac ggg acc ctg ccg ctg cgc agc agt 13499 Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser 1080 1085 1090 atc cgg gga gtc cag cgc gtg acc gtc act gac gcc aga cgc cgc 13544 Ile Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg Arg 1095 1100 1105 acc tgc ccc tac gtc tac aag gcc ctg ggc gta gtc gcg ccg cgc 13589 Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Val Val Ala Pro Arg 1110 1115 1120 gtc ctc tcg agc cgc acc ttc taaaaa atg tcc att ctc atc tcg ccc 13637 Val Leu Ser Ser Arg Thr Phe Met Ser Ile Leu Ile Ser Pro 1125 1130 1135 agt aat aac acc ggt tgg ggc ctg cgc gcg ccc agc aag atg tac 13682 Ser Asn Asn Thr Gly Trp Gly Leu Arg Ala Pro Ser Lys Met Tyr 1140 1145 1150 gga ggc gct cgc caa cgc tcc acg caa cac ccc gtg cgc gtg cgc 13727 Gly Gly Ala Arg Gln Arg Ser Thr Gln His Pro Val Arg Val Arg 1155 1160 1165 ggg cac ttc cgc gct ccc tgg ggc gcc ctc aag ggc cgc gtg cgc 13772 Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys Gly Arg Val Arg 1170 1175 1180 tcg cgc acc acc gtc gac gac gtg atc gac cag gtg gtg gcc gac 13817 Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val Val Ala Asp 1185 1190 1195 gcg cgc aac tac acg ccc gcc gcc gcg ccc gcc tcc acc gtg gac 13862 Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Ala Ser Thr Val Asp 1200 1205 1210 gcc gtc atc gac agc gtg gtg gcc gac gcg cgc cgg tac gcc cgc 13907 Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala Arg 1215 1220 1225 gcc aag agc cgg cgg cgg cgc atc gcc cgg cgg cac cgg agc acc 13952 Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 1230 1235 1240 ccc gcc atg cgc gcg gcg cga gcc ttg ctg cgc agg gcc agg cgc 13997 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg 1245 1250 1255 acg gga cgc agg gcc atg ctc agg gcg gcc aga cgc gcg gcc tcc 14042 Thr Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser 1260 1265 1270 ggc agc agc agc gcc ggc agg acc cgc aga cgc gcg gcc acg gcg 14087 Gly Ser Ser Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala 1275 1280 1285 gcg gcg gcg gcc atc gcc agc atg tcc cgc ccg cgg cgc ggc aac 14132 Ala Ala Ala Ala Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn 1290 1295 1300 gtg tac tgg gtg cgc gac gcc gcc acc ggt gtg cgc gtg ccc gtg 14177 Val Tyr Trp Val Arg Asp Ala Ala Thr Gly Val Arg Val Pro Val 1305 1310 1315 cgc acc cgc ccc cct cgc act tgaagatgct gacttcgcga tgttgatgtg 14228 Arg Thr Arg Pro Pro Arg Thr 1320 tcccagcggc gaggagg atg tcc aag cgc aaa ttc aag gaa gag atg ctc 14278 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu 1325 1330 cag gtc atc gcg cct gag atc tac ggc ccc gcg gcg gcg gtg aag 14323 Gln Val Ile Ala Pro Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys 1335 1340 1345 gag gaa aga aag ccc cgc aaa ctg aag cgg gtc aaa aag gac aaa 14368 Glu Glu Arg Lys Pro Arg Lys Leu Lys Arg Val Lys Lys Asp Lys 1350 1355 1360 aag gag gag gaa gat gac gga ctg gtg gag ttt gtg cgc gag ttc 14413 Lys Glu Glu Glu Asp Asp Gly Leu Val Glu Phe Val Arg Glu Phe 1365 1370 1375 gcc ccc cgg cgg cgc gtg cag tgg cgc ggg cgg aaa gtg aaa ccg 14458 Ala Pro Arg Arg Arg Val Gln Trp Arg Gly Arg Lys Val Lys Pro 1380 1385 1390 gtg ctg cgg ccc ggc acc acg gtg gtc ttc acg ccc ggc gag cgt 14503 Val Leu Arg Pro Gly Thr Thr Val Val Phe Thr Pro Gly Glu Arg 1395 1400 1405 tcc ggc tcc gcc tcc aag cgc tcc tac gac gag gtg tac ggg gac 14548 Ser Gly Ser Ala Ser Lys Arg Ser Tyr Asp Glu Val Tyr Gly Asp 1410 1415 1420 gag gac atc ctc gag cag gcg gcc gag cgt ctg ggc gag ttt gct 14593 Glu Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu Gly Glu Phe Ala 1425 1430 1435 tac ggc aag cgc agc cgc ccc gcg ccc ttg aaa gag gag gcg gtg 14638 Tyr Gly Lys Arg Ser Arg Pro Ala Pro Leu Lys Glu Glu Ala Val 1440 1445 1450 tcc atc ccg ctg gac cac ggc aac ccc acg ccg agc ctg aag ccg 14683 Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu Lys Pro 1455 1460 1465 gtg acc ctg cag cag gtg ctg ccg agc gcg gcg ccg cgc cgg ggc 14728 Val Thr Leu Gln Gln Val Leu Pro Ser Ala Ala Pro Arg Arg Gly 1470 1475 1480 ttc aag cgc gag ggc ggc gag gat ctg tac ccg acc atg cag ctg 14773 Phe Lys Arg Glu Gly Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu 1485 1490 1495 atg gtg ccc aag cgc cag aag ctg gag gac gtg ctg gag cac atg 14818 Met Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu His Met 1500 1505 1510 aag gtg gac ccc gag gtg cag ccc gag gtc aag gtg cgg ccc atc 14863 Lys Val Asp Pro Glu Val Gln Pro Glu Val Lys Val Arg Pro Ile 1515 1520 1525 aag cag gtg gcc ccg ggc ctg ggc gtg cag acc gtg gac atc aag 14908 Lys Gln Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys 1530 1535 1540 atc ccc acg gag ccc atg gaa acg cag acc gag ccc gtg aag ccc 14953 Ile Pro Thr Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro 1545 1550 1555 agc acc agc acc atg gag gtg cag acg gat ccc tgg atg ccg gcg 14998 Ser Thr Ser Thr Met Glu Val Gln Thr Asp Pro Trp Met Pro Ala 1560 1565 1570 ccg gct tcc acc acc acc acc acc cgc cga aga cgc aag tac ggc 15043 Pro Ala Ser Thr Thr Thr Thr Thr Arg Arg Arg Arg Lys Tyr Gly 1575 1580 1585 gcg gcc agc ctg ctg atg ccc aac tac gcg ctg cat cct tcc atc 15088 Ala Ala Ser Leu Leu Met Pro Asn Tyr Ala Leu His Pro Ser Ile 1590 1595 1600 atc ccc acg ccg ggc tac cgc ggc acg cgc ttc tac cgc ggc tac 15133 Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg Phe Tyr Arg Gly Tyr 1605 1610 1615 agc agc cgc cgc aag acc acc acc cgc cgc cgc cgt cgc cgc acc 15178 Ser Ser Arg Arg Lys Thr Thr Thr Arg Arg Arg Arg Arg Arg Thr 1620 1625 1630 cgc cgc agc acc acc gcg act tcc gcc gcc gcc ttg gtg cgg aga 15223 Arg Arg Ser Thr Thr Ala Thr Ser Ala Ala Ala Leu Val Arg Arg 1635 1640 1645 gtg tac cgc agc ggg cgt gag cct ctg acc ctg ccg cgc gcg cgc 15268 Val Tyr Arg Ser Gly Arg Glu Pro Leu Thr Leu Pro Arg Ala Arg 1650 1655 1660 tac cac ccg agc atc gcc att taactctgcc gtcgcctcct tgcagat atg 15319 Tyr His Pro Ser Ile Ala Ile Met 1665 1670 gcc ctc aca tgc cgc ctc cgc gtc ccc att acg ggc tac cga gga 15364 Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1675 1680 1685 aga aag ccg cgc cgt aga agg ctg acg ggg aac ggg ctg cgt cgc 15409 Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly Asn Gly Leu Arg Arg 1690 1695 1700 cat cac cac cgg cgg cgg cgc gcc atc agc aag cgg ttg ggg gga 15454 His His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly 1705 1710 1715 ggc ttc ctg ccc gcg ctg atc ccc atc atc gcc gcg gcg atc ggg 15499 Gly Phe Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly 1720 1725 1730 gcg atc ccc ggc ata gct tcc gtg gcg gtg cag gcc tct cag cgc 15544 Ala Ile Pro Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg 1735 1740 1745 cac tgagacacag cttggaaaat ttgtaataaa aaaatggact gacgctcctg 15597 His gtcctgtgat gtgtgttttt ag atg gaa gac atc aat ttt tcg tcc ctg 15646 Met Glu Asp Ile Asn Phe Ser Ser Leu 1750 1755 gca ccg cga cac ggc acg cgg ccg ttt atg ggc acc tgg agc gac 15691 Ala Pro Arg His Gly Thr Arg Pro Phe Met Gly Thr Trp Ser Asp 1760 1765 1770 atc ggc aac agc caa ctg aac ggg ggc gcc ttc aat tgg agc agt 15736 Ile Gly Asn Ser Gln Leu Asn Gly Gly Ala Phe Asn Trp Ser Ser 1775 1780 1785 ctc tgg agc ggg ctt aag aat ttc ggg tcc acg ctc aaa acc tat 15781 Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser Thr Leu Lys Thr Tyr 1790 1795 1800 ggc agc aag gcg tgg aac agc acc aca ggg cag gcg ctg agg gat 15826 Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly Gln Ala Leu Arg Asp 1805 1810 1815 aag ctg aaa gag cag aac ttc cag cag aag gtg gtc gat ggg ctc 15871 Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val Val Asp Gly Leu 1820 1825 1830 gct tcg ggc atc aac ggg gtg gtg gac ctg gcc aac cag gcc gtg 15916 Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn Gln Ala Val 1835 1840 1845 cag cgg cag atc aac agc cgc ctg gac ccg gtg ccg ccc gcc ggc 15961 Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro Ala Gly 1850 1855 1860 tcc gtg gag atg ccg cag gtg gag gag gag ctg cct ccc ctg gac 16006 Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu Asp 1865 1870 1875 aag cgg ggc gag aag cga ccc cgc ccc gac gcg gag gag acg ctg 16051 Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu 1880 1885 1890 ctg acg cac acg gac gag ccg ccc ccg tac gag gag gcg gtg aaa 16096 Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys 1895 1900 1905 ctg ggt ctg ccc acc acg cgg ccc att gcg ccc cta gcc acc ggg 16141 Leu Gly Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly 1910 1915 1920 gtg ctg aaa ccc gag agt aat aag ccc gcg acc ctg gac ttg cct 16186 Val Leu Lys Pro Glu Ser Asn Lys Pro Ala Thr Leu Asp Leu Pro 1925 1930 1935 cct ccc cag cct tcc cgc ccc tcc aca gtg gct aag ccc ctg ccg 16231 Pro Pro Gln Pro Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro 1940 1945 1950 ccg gtg gcc gtg gcc cgc gcg cga ccc ggg ggc tcc gcc cgc cct 16276 Pro Val Ala Val Ala Arg Ala Arg Pro Gly Gly Ser Ala Arg Pro 1955 1960 1965 cat gcg aac tgg cag agc act ctg aac agc atc gtg ggt ctg gga 16321 His Ala Asn Trp Gln Ser Thr Leu Asn Ser Ile Val Gly Leu Gly 1970 1975 1980 gtg cag agt gtg aag cgc cgc cgc tgc tat taaacctacc gtagcgctta 16371 Val Gln Ser Val Lys Arg Arg Arg Cys Tyr 1985 1990 acttgcttgt ctgtgtgtgt atgtattatg tcgccgccgc tgtccgccag aaggaggagt 16431 gaagaggcgc gtcgccgagt tgcaag atg gcc acc cca tcg atg ctg ccc 16481 Met Ala Thr Pro Ser Met Leu Pro 1995 2000 cag tgg gcg tac atg cac atc gcc gga cag gac gct tcg gag tac 16526 Gln Trp Ala Tyr Met His Ile Ala Gly Gln Asp Ala Ser Glu Tyr 2005 2010 2015 ctg agt ccg ggt ctg gtg cag ttc gcc cgc gcc aca gac acc tac 16571 Leu Ser Pro Gly Leu Val Gln Phe Ala Arg Ala Thr Asp Thr Tyr 2020 2025 2030 ttc agt ctg ggg aac aag ttt agg aac ccc acg gtg gcg ccc acg 16616 Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro Thr Val Ala Pro Thr 2035 2040 2045 cac gat gtg acc acc gac cgc agc cag cgg ctg acg ctg cgc ttc 16661 His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu Thr Leu Arg Phe 2050 2055 2060 gtg ccc gtg gac cgc gag gac aac acc tac tcg tac aaa gtg cgc 16706 Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr Lys Val Arg 2065 2070 2075 tac acg ctg gcc gtg ggc gac aac cgc gtg ctg gac atg gcc agc 16751 Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met Ala Ser 2080 2085 2090 acc tac ttt gac atc cgc ggc gtg ctg gac cgg ggc cct agc ttc 16796 Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser Phe 2095 2100 2105 aaa ccc tac tcc ggc acc gcc tac aac agc ctg gct ccc aag gga 16841 Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 2110 2115 2120 gcg ccc aat tcc agc cag tgg gag cga gct aag aca aac aat aac 16886 Ala Pro Asn Ser Ser Gln Trp Glu Arg Ala Lys Thr Asn Asn Asn 2125 2130 2135 gga gcc acg gaa tct gtt acc ttt ggt gtg gct gcc atg ggg ggt 16931 Gly Ala Thr Glu Ser Val Thr Phe Gly Val Ala Ala Met Gly Gly 2140 2145 2150 ata gat att aca aaa gag ggt ctc cag att gga act gat gaa act 16976 Ile Asp Ile Thr Lys Glu Gly Leu Gln Ile Gly Thr Asp Glu Thr 2155 2160 2165 aaa gct gat agt aaa gaa att tat gca gac aaa acc tac caa cct 17021 Lys Ala Asp Ser Lys Glu Ile Tyr Ala Asp Lys Thr Tyr Gln Pro 2170 2175 2180 gaa cct cag ata gga gag gag aac tgg caa gaa aca ttc tcc tat 17066 Glu Pro Gln Ile Gly Glu Glu Asn Trp Gln Glu Thr Phe Ser Tyr 2185 2190 2195 tat ggc ggc aga gct ctt aaa aaa gat acc aag atg aag cca tgc 17111 Tyr Gly Gly Arg Ala Leu Lys Lys Asp Thr Lys Met Lys Pro Cys 2200 2205 2210 tac ggc tcc ttt gct aaa cca acg aat gtc aaa gga ggt cag gcc 17156 Tyr Gly Ser Phe Ala Lys Pro Thr Asn Val Lys Gly Gly Gln Ala 2215 2220 2225 aaa ttt aaa gtt cag gac ggt caa caa act aca gaa tat gat atc 17201 Lys Phe Lys Val Gln Asp Gly Gln Gln Thr Thr Glu Tyr Asp Ile 2230 2235 2240 gac tta gct ttc ttt gat att cca aac tct gga aca gga ggg aat 17246 Asp Leu Ala Phe Phe Asp Ile Pro Asn Ser Gly Thr Gly Gly Asn 2245 2250 2255 ggc acg aat gtt aat tat gat cca gat atg gtc atg tac act gaa 17291 Gly Thr Asn Val Asn Tyr Asp Pro Asp Met Val Met Tyr Thr Glu 2260 2265 2270 aat gtg gat ttg gag acc cct gat acc cac att gtt tac aaa cca 17336 Asn Val Asp Leu Glu Thr Pro Asp Thr His Ile Val Tyr Lys Pro 2275 2280 2285 ggg act tcc gat gac agt tct gaa gca aac ttg ctt cag cag tcc 17381 Gly Thr Ser Asp Asp Ser Ser Glu Ala Asn Leu Leu Gln Gln Ser 2290 2295 2300 atg cct aac aga ccc aac tat att ggg ttt aga gac aac ttt atc 17426 Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile 2305 2310 2315 ggt ctc atg tac tac aac agt act ggc aat atg ggt gtg ctg gct 17471 Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala 2320 2325 2330 ggt cag gcc tcc cag ctg aat gct gtg gtc gac ttg caa gac aga 17516 Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg 2335 2340 2345 aac acc gag cta tcc tac cag ctc ttg ctt gac tct ctg ggc gat 17561 Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp 2350 2355 2360 aga acc cgg tat ttc agt atg tgg aac cag gcg gtg gac agt tat 17606 Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr 2365 2370 2375 gac cct gat gtg cgc att att gaa aac cat ggt gtg gaa gat gaa 17651 Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu 2380 2385 2390 ctt ccc aac tat tgc ttc cca ttg gat gga gct ggt act aat gct 17696 Leu Pro Asn Tyr Cys Phe Pro Leu Asp Gly Ala Gly Thr Asn Ala 2395 2400 2405 gtc tat cag ggt gtt aaa gca aaa act aat gga ggc gca gcc aat 17741 Val Tyr Gln Gly Val Lys Ala Lys Thr Asn Gly Gly Ala Ala Asn 2410 2415 2420 gga gat tgg gag caa gat aca gac gtg tca aac att aac cag ata 17786 Gly Asp Trp Glu Gln Asp Thr Asp Val Ser Asn Ile Asn Gln Ile 2425 2430 2435 tgc aag ggg aac atc tat gcc atg gaa atc aac ctc caa gcc aac 17831 Cys Lys Gly Asn Ile Tyr Ala Met Glu Ile Asn Leu Gln Ala Asn 2440 2445 2450 ctg tgg aga agt ttc ctc tac tcg aac gtg gcc ctg tac ctg ccc 17876 Leu Trp Arg Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr Leu Pro 2455 2460 2465 gat tct tac aag tac acg ccg gcc aac atc acc ttg ccc acg aat 17921 Asp Ser Tyr Lys Tyr Thr Pro Ala Asn Ile Thr Leu Pro Thr Asn 2470 2475 2480 acc aac acc tat gat tac atg aat ggg aga gtg gcg cct ccc tcg 17966 Thr Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val Ala Pro Pro Ser 2485 2490 2495 ttg gtg gat gcc tac atc aac atc ggg gcg cgc tgg tcg ctg gac 18011 Leu Val Asp Ala Tyr Ile Asn Ile Gly Ala Arg Trp Ser Leu Asp 2500 2505 2510 ccc atg gac aac gtc aat ccc ttc aac cac cac cgc aac gcg ggg 18056 Pro Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly 2515 2520 2525 ctg cgc tac cgc tcc atg ctt ctg ggc aac ggg cgc ttc gtg ccc 18101 Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Phe Val Pro 2530 2535 2540 ttc cac atc cag gtg ccc cag aaa ttt ttc gcc atc aag agc ctc 18146 Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu 2545 2550 2555 ctg ctc ctg ccc ggg tcc tac acc tac gag tgg aac ttc cgc aag 18191 Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys 2560 2565 2570 gac gtc aac atg atc ctg cag agc tcc ctc ggc aac gac ctg cgc 18236 Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg 2575 2580 2585 acg gac ggg gcc tcc atc tcc ttc acc agc atc aac ctc tac gcc 18281 Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala 2590 2595 2600 acc ttc ttc ccc atg gcg cac aac acg gcc tcc acg ctc gag gcc 18326 Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala 2605 2610 2615 atg ctg cgc aac gac acc aac gac cag tcc ttc aac gac tac ctc 18371 Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu 2620 2625 2630 tcg gcg gcc aac atg ctc tac ccc atc cca gcc aac gcc acc aac 18416 Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn 2635 2640 2645 gtg ccc atc tcc atc ccc tcg cgc aac tgg gcc gcc ttc cgc ggc 18461 Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly 2650 2655 2660 tgg tcc ttc acg cgt ctc aag acc aag gag acg ccc tcg ctg ggc 18506 Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly 2665 2670 2675 tcc ggg ttc gac ccc tac ttc gtc tac tcg ggc tcc atc ccc tac 18551 Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr 2680 2685 2690 ctc gac ggc acc ttc tac ctc aac cac acc ttc aag aag gtc tcc 18596 Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser 2695 2700 2705 atc acc ttc gac tcc tcc gtc agc tgg ccc ggc aac gac cgg ctc 18641 Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu 2710 2715 2720 ctg acg ccc aac gag ttc gaa atc aag cgc acc gtc gac ggc gag 18686 Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu 2725 2730 2735 ggc tac aac gtg gcc cag tgc aac atg acc aag gac tgg ttc ctg 18731 Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu 2740 2745 2750 gtc cag atg ctg gcc cac tac aac atc ggc tac cag ggc ttc tac 18776 Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr 2755 2760 2765 gtg ccc gag ggc tac aag gac cgc atg tac tcc ttc ttc cgc aac 18821 Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn 2770 2775 2780 ttc cag ccc atg agc cgc cag gtg gtg gac gag gtc aac tac aag 18866 Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Val Asn Tyr Lys 2785 2790 2795 gac tac cag gcc gtc acc ctg gcc tac cag cac aac aac tcg ggc 18911 Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn Asn Ser Gly 2800 2805 2810 ttc gtc ggc tac ctc gcg ccc acc atg cgc cag ggc cag ccc tac 18956 Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln Pro Tyr 2815 2820 2825 ccc gcc aac tac ccg tac ccg ctc atc ggc aag agc gcc gtc acc 19001 Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val Thr 2830 2835 2840 agc gtc acc cag aaa aag ttc ctc tgc gac agg gtc atg tgg cgc 19046 Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met Trp Arg 2845 2850 2855 atc ccc ttc tcc agc aac ttc atg tcc atg ggc gcg ctc acc gac 19091 Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp 2860 2865 2870 ctc ggc cag aac atg ctc tat gcc aac tcc gcc cac gcg cta gac 19136 Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu Asp 2875 2880 2885 atg aat ttc gaa gtc gac ccc atg gat gag tcc acc ctt ctc tat 19181 Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr 2890 2895 2900 gtt gtc ttc gaa gtc ttc gac gtc gtc cga gtg cac cag ccc cac 19226 Val Val Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro His 2905 2910 2915 cgc ggc gtc atc gag gcc gtc tac ctg cgc acc ccc ttc tcg gcc 19271 Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala 2920 2925 2930 ggt aac gcc acc acc taagctcttg cttcttgcaa g atg gct gag ccc acg 19322 Gly Asn Ala Thr Thr Met Ala Glu Pro Thr 2935 2940 ggc tcc ggc gag cag gag ctc agg gcc atc atc cgc gac ctg ggc 19367 Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile Arg Asp Leu Gly 2945 2950 2955 tgc ggg ccc tac ttc ctg ggc acc ttc gat aag cgc ttc ccg gga 19412 Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg Phe Pro Gly 2960 2965 2970 ttc atg gcc ccg cac aag ctg gcc tgc gcc atc gtc aac acg gcc 19457 Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn Thr Ala 2975 2980 2985 ggc cgc gag acc ggg ggc gag cac tgg ctg gcc ttc gcc tgg aac 19502 Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp Asn 2990 2995 3000 ccg cgc tcg aac acc tgc tac ctc ttc gac ccc ttc ggg ttc tcg 19547 Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser 3005 3010 3015 gac gag cgc ctc aag cag atc tac cag ttc gag tac gag ggc ctg 19592 Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu 3020 3025 3030 ctg cgc cgc agc gcc ctg gcc acc gag gac cgc tgc gtc acc ctg 19637 Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu 3035 3040 3045 gaa aag tcc acc cag acc gtg cag ggt ccg cgc tcg gcc gcc tgc 19682 Glu Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys 3050 3055 3060 ggg ctc ttt tgc tgc atg ttc ctg cac gcc ttc gtg cac tgg ccc 19727 Gly Leu Phe Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro 3065 3070 3075 gac cgc ccc atg gac aag aac ccc acc atg aac ttg ctg acg ggg 19772 Asp Arg Pro Met Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly 3080 3085 3090 gtg ccc aac ggc atg ctc cag tcg ccc cag gtg gaa ccc acc ctg 19817 Val Pro Asn Gly Met Leu Gln Ser Pro Gln Val Glu Pro Thr Leu 3095 3100 3105 cgc cgc aac cag gag gcg ctc tac cgc ttc ctc aac gcc cac tcc 19862 Arg Arg Asn Gln Glu Ala Leu Tyr Arg Phe Leu Asn Ala His Ser 3110 3115 3120 gcc tac ttt cgc tcc cac cgc gcg cgc atc gag aag gcc acc gcc 19907 Ala Tyr Phe Arg Ser His Arg Ala Arg Ile Glu Lys Ala Thr Ala 3125 3130 3135 ttc gac cgc atg aat caa gac atg taaaccgtgt gtgtatgtga atgctttatt 19961 Phe Asp Arg Met Asn Gln Asp Met 3140 cataataaac agcacatgtt tatgccacct tctctgaggc tctgacttta ttta gaa 20018 Glu atc gaa ggg gtt ctg ccg gct ctc ggc gtg ccc cgc ggg cag gga 20063 Ile Glu Gly Val Leu Pro Ala Leu Gly Val Pro Arg Gly Gln Gly 3145 3150 3155 tac gtt gcg gaa ctg gta ctt ggg cag cca ctt gaa ctc ggg gat 20108 Tyr Val Ala Glu Leu Val Leu Gly Gln Pro Leu Glu Leu Gly Asp 3160 3165 3170 cag cag ctt cgg cac ggg gag gtc ggg gaa cga gtc gct cca cag 20153 Gln Gln Leu Arg His Gly Glu Val Gly Glu Arg Val Ala Pro Gln 3175 3180 3185 ctt gcg cgt gag ttg cag ggc gcc cag cag gtc ggg cgc gga gat 20198 Leu Ala Arg Glu Leu Gln Gly Ala Gln Gln Val Gly Arg Gly Asp 3190 3195 3200 ctt gaa atc gca gtt ggg acc cgc gtt ctg cgc gcg aga gtt gcg 20243 Leu Glu Ile Ala Val Gly Thr Arg Val Leu Arg Ala Arg Val Ala 3205 3210 3215 gta cac ggg gtt gca gca ctg gaa cac cat cag ggc cgg gtg ctt 20288 Val His Gly Val Ala Ala Leu Glu His His Gln Gly Arg Val Leu 3220 3225 3230 cac gct cgc cag cac cgt cgc gtc ggt gat gcc ctc cac gtc cag 20333 His Ala Arg Gln His Arg Arg Val Gly Asp Ala Leu His Val Gln 3235 3240 3245 atc ctc ggc gtt ggc cat ccc gaa ggg ggt cat ctt gca ggt ctg 20378 Ile Leu Gly Val Gly His Pro Glu Gly Gly His Leu Ala Gly Leu 3250 3255 3260 ccg ccc cat gct ggg cac gca gcc ggg ctt gtg gtt gca atc gca 20423 Pro Pro His Ala Gly His Ala Ala Gly Leu Val Val Ala Ile Ala 3265 3270 3275 gtg cag ggg gat cag cat cat ctg ggc ctg ctc gga gct cat gcc 20468 Val Gln Gly Asp Gln His His Leu Gly Leu Leu Gly Ala His Ala 3280 3285 3290 cgg gta cat ggc ctt cat gaa agc ctc cag ctg gcg gaa ggc ctg 20513 Arg Val His Gly Leu His Glu Ser Leu Gln Leu Ala Glu Gly Leu 3295 3300 3305 ctg cgc ctt gcc gcc ctc ggt gaa gaa gac ccc gca gga ctt gct 20558 Leu Arg Leu Ala Ala Leu Gly Glu Glu Asp Pro Ala Gly Leu Ala 3310 3315 3320 aga gaa ctg gtt ggt agc gca gcc cgc gtc gtg cac gca gca gcg 20603 Arg Glu Leu Val Gly Ser Ala Ala Arg Val Val His Ala Ala Ala 3325 3330 3335 cgc gtc gtt gtt ggc cag ctg cac cac gct gcg ccc cca gcg gtt 20648 Arg Val Val Val Gly Gln Leu His His Ala Ala Pro Pro Ala Val 3340 3345 3350 ctg ggt gat ctt ggc ccg gtc ggg gtt ctc ctt cag cgc gcg ctg 20693 Leu Gly Asp Leu Gly Pro Val Gly Val Leu Leu Gln Arg Ala Leu 3355 3360 3365 ccc gtt ctc gct cgc cac atc cat ctc gat cgt gtg ctc ctt ctg 20738 Pro Val Leu Ala Arg His Ile His Leu Asp Arg Val Leu Leu Leu 3370 3375 3380 gat cat cac ggt ccc gtg cag gca ccg cag ctt gcc ctc ggc ctc 20783 Asp His His Gly Pro Val Gln Ala Pro Gln Leu Ala Leu Gly Leu 3385 3390 3395 ggt gca gcc gtg cag cca cag cgc gca gcc ggt gct ctc cca gtt 20828 Gly Ala Ala Val Gln Pro Gln Arg Ala Ala Gly Ala Leu Pro Val 3400 3405 3410 ctt gtg ggc gat ctg gga gtg cga gtg cac gaa gcc ctg cag gaa 20873 Leu Val Gly Asp Leu Gly Val Arg Val His Glu Ala Leu Gln Glu 3415 3420 3425 gcg gcc cat cat cgc ggt cag ggt ctt gtt gct ggt gaa ggt cag 20918 Ala Ala His His Arg Gly Gln Gly Leu Val Ala Gly Glu Gly Gln 3430 3435 3440 cgg gat gcc gcg gtg ctc ctc gtt cac ata cag gtg gca gat gcg 20963 Arg Asp Ala Ala Val Leu Leu Val His Ile Gln Val Ala Asp Ala 3445 3450 3455 gcg gta cac ctc gcc ctg ctc ggg cat cag ctg gaa ggc gga ctt 21008 Ala Val His Leu Ala Leu Leu Gly His Gln Leu Glu Gly Gly Leu 3460 3465 3470 cag gtc gct ctc cac gcg gta ccg gtc cat cag cag cgt cat cac 21053 Gln Val Ala Leu His Ala Val Pro Val His Gln Gln Arg His His 3475 3480 3485 ttc cat gcc ctt ctc cca ggc cga aac gat cgg cag gct cag ggg 21098 Phe His Ala Leu Leu Pro Gly Arg Asn Asp Arg Gln Ala Gln Gly 3490 3495 3500 gtt ctt cac cgt cat ctt agt cgc cgc cgc cga agt cag ggg gtc 21143 Val Leu His Arg His Leu Ser Arg Arg Arg Arg Ser Gln Gly Val 3505 3510 3515 gtt ctc gtc cag ggt ctc aaa cac tcg ctt gcc gtc ctt ctc ggt 21188 Val Leu Val Gln Gly Leu Lys His Ser Leu Ala Val Leu Leu Gly 3520 3525 3530 gat gcg cac ggg ggg gaa ggc gaa gcc cac ggc cgc cag ctc ctc 21233 Asp Ala His Gly Gly Glu Gly Glu Ala His Gly Arg Gln Leu Leu 3535 3540 3545 ctc ggc ctg cct ttc gtc ctc gct gtc ctg gct gat gtc ttg caa 21278 Leu Gly Leu Pro Phe Val Leu Ala Val Leu Ala Asp Val Leu Gln 3550 3555 3560 agg cac atg ctt ggt ctt gcg ggg ttt ctt ttt ggg cgg cag agg 21323 Arg His Met Leu Gly Leu Ala Gly Phe Leu Phe Gly Arg Gln Arg 3565 3570 3575 cgg cgg cgg cgg aga cgt gct ggg cga gcg cga gtt ctc gct cac 21368 Arg Arg Arg Arg Arg Arg Ala Gly Arg Ala Arg Val Leu Ala His 3580 3585 3590 cac gac tat ttc ttc ttc ttg gcc gtc gtc cga gac cac gcg gcg 21413 His Asp Tyr Phe Phe Phe Leu Ala Val Val Arg Asp His Ala Ala 3595 3600 3605 gta ggc atg cct ctt ctg ggg cag agg cgg agg cga cgg gct ctc 21458 Val Gly Met Pro Leu Leu Gly Gln Arg Arg Arg Arg Arg Ala Leu 3610 3615 3620 gcg gtt cgg cgg gcg gct ggc aga gcc cct tcc gcg ttc ggg ggt 21503 Ala Val Arg Arg Ala Ala Gly Arg Ala Pro Ser Ala Phe Gly Gly 3625 3630 3635 gcg ctc ctg gcg gcg ctg ctc tga ctg act tcc tcc gcg gcc ggc 21548 Ala Leu Leu Ala Ala Leu Leu Leu Thr Ser Ser Ala Ala Gly 3640 3645 3650 cat tgtgttctcc tagggagcaa caacaagc atg gag act cag cca tcg tcg 21600 His Met Glu Thr Gln Pro Ser Ser 3655 3660 cca aca tcg cca tct gcc ccc gcc gcc gcc gac gag aac cag cag 21645 Pro Thr Ser Pro Ser Ala Pro Ala Ala Ala Asp Glu Asn Gln Gln 3665 3670 3675 cag cag aat gaa agc tta acc gcc ccg ccg ccc agc ccc acc tcc 21690 Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro Pro Ser Pro Thr Ser 3680 3685 3690 gac gcc gcg gcc cca gac atg caa gag atg gag gaa tcc atc gag 21735 Asp Ala Ala Ala Pro Asp Met Gln Glu Met Glu Glu Ser Ile Glu 3695 3700 3705 att gac ctg ggc tac gtg acg ccc gcg gag cac gag gag gag ctg 21780 Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu Glu Glu Leu 3710 3715 3720 gca gcg cgc ttt tca gcc ccg gaa gag aac cac caa gag cag cca 21825 Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln Glu Gln Pro 3725 3730 3735 gag cag gaa gca gag agc gag cag agc cag gct ggg ctc gag cat 21870 Glu Gln Glu Ala Glu Ser Glu Gln Ser Gln Ala Gly Leu Glu His 3740 3745 3750 ggc gac tac ctg agc ggg gca gag gac gtg ctc atc aag cat ctg 21915 Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu Ile Lys His Leu 3755 3760 3765 gcc cgc caa tgc atc atc gtc aag gac gcg ctg ctc gac cgc gcc 21960 Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Ala 3770 3775 3780 gag gtg ccc ctc agc gtg gcg gag ctc agc cgc gcc tac gag cgc 22005 Glu Val Pro Leu Ser Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg 3785 3790 3795 aac ctc ttc tcg ccg cgc gtg ccc ccc aag cgc cag ccc aac ggc 22050 Asn Leu Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly 3800 3805 3810 acc tgc gag ccc aac ccg cgc ctc aac ttc tac ccg gtc ttc gcg 22095 Thr Cys Glu Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala 3815 3820 3825 gtg ccc gag gcc ctg gcc acc tac cac ctc ttt ttc aag aac caa 22140 Val Pro Glu Ala Leu Ala Thr Tyr His Leu Phe Phe Lys Asn Gln 3830 3835 3840 agg atc ccc gtc tcc tgc cgc gcc aac cgc acc cgc gcc gac gcc 22185 Arg Ile Pro Val Ser Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala 3845 3850 3855 ctg ctc aac ctg ggc ccc ggc gcc cgc cta cct gat atc gcc tcc 22230 Leu Leu Asn Leu Gly Pro Gly Ala Arg Leu Pro Asp Ile Ala Ser 3860 3865 3870 ttg gaa gag gtt ccc aag atc ttc gag ggt ctg ggc agc gac gag 22275 Leu Glu Glu Val Pro Lys Ile Phe Glu Gly Leu Gly Ser Asp Glu 3875 3880 3885 act cgg gcc gcg aac gct ctg caa gga agc gga gag gag cat gag 22320 Thr Arg Ala Ala Asn Ala Leu Gln Gly Ser Gly Glu Glu His Glu 3890 3895 3900 cac cac agc gcc ctg gtg gag ttg gaa ggc gac aac gcg cgc ctg 22365 His His Ser Ala Leu Val Glu Leu Glu Gly Asp Asn Ala Arg Leu 3905 3910 3915 gcg gtc ctc aag cgc acg gtc gag ctg acc cac ttc gcc tac ccg 22410 Ala Val Leu Lys Arg Thr Val Glu Leu Thr His Phe Ala Tyr Pro 3920 3925 3930 gcg ctc aac ctg ccc ccc aag gtc atg agc gcc gtc atg gac cag 22455 Ala Leu Asn Leu Pro Pro Lys Val Met Ser Ala Val Met Asp Gln 3935 3940 3945 gtg ctc atc aag cgc gcc tcg ccc ctc tcg gag gag gag atg cag 22500 Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu Glu Glu Met Gln 3950 3955 3960 gac ccc gag agc tcg gac gag ggc aag ccc gtg gtc agc gac gag 22545 Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val Val Ser Asp Glu 3965 3970 3975 cag ctg gcg cgc tgg ctg gga acg agt agc acc ccc cag agt ctg 22590 Gln Leu Ala Arg Trp Leu Gly Thr Ser Ser Thr Pro Gln Ser Leu 3980 3985 3990 gaa gag cgg cgc aag ctc atg atg gcc gtg gtc ctg gtg acc gtg 22635 Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr Val 3995 4000 4005 gag ctt gag tgt ctg cgc cgc ttc ttc gcc gac gcg gag acc ctg 22680 Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu 4010 4015 4020 cgc aag gtc gag gag aac ctg cac tac ctc ttc agg cac ggg ttc 22725 Arg Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe 4025 4030 4035 gtg cgc cag gcc tgc aag atc tcc aac gtg gag ctg acc aac ctg 22770 Val Arg Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu 4040 4045 4050 gtc tcc tac atg ggc atc ctg cac gag aac cgc ctg ggg cag aac 22815 Val Ser Tyr Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn 4055 4060 4065 gtg ctg cac acc acc ctg cgc ggg gag gcc cgc cgc gac tac atc 22860 Val Leu His Thr Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile 4070 4075 4080 cgc gac tgc gtc tac ctg tac ctc tgc cac acc tgg cag acg ggc 22905 Arg Asp Cys Val Tyr Leu Tyr Leu Cys His Thr Trp Gln Thr Gly 4085 4090 4095 atg ggc gtg tgg cag cag tgc ctg gag gag cag aac ctg aaa gag 22950 Met Gly Val Trp Gln Gln Cys Leu Glu Glu Gln Asn Leu Lys Glu 4100 4105 4110 ctc tgc aag ctc ctg cag aag aac ctg aag gcc ctg tgg acc ggg 22995 Leu Cys Lys Leu Leu Gln Lys Asn Leu Lys Ala Leu Trp Thr Gly 4115 4120 4125 ttc gac gag cgt acc acc gcc tcg gac ctg gcc gac ctc atc ttc 23040 Phe Asp Glu Arg Thr Thr Ala Ser Asp Leu Ala Asp Leu Ile Phe 4130 4135 4140 ccc gag cgc ctg cgg ctg acg ctg cgc aac ggg ctg ccc gac ttt 23085 Pro Glu Arg Leu Arg Leu Thr Leu Arg Asn Gly Leu Pro Asp Phe 4145 4150 4155 atg agc caa agc atg ttg caa aac ttt cgc tct ttc atc ctc gaa 23130 Met Ser Gln Ser Met Leu Gln Asn Phe Arg Ser Phe Ile Leu Glu 4160 4165 4170 cgc tcc ggg atc ctg ccc gcc acc tgc tcc gcg ctg ccc tcg gac 23175 Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala Leu Pro Ser Asp 4175 4180 4185 ttc gtg ccg ctg acc ttc cgc gag tgc ccc ccg ccg ctc tgg agc 23220 Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro Leu Trp Ser 4190 4195 4200 cac tgc tac ttg ctg cgc ctg gcc aac tac ctg gcc tac cac tcg 23265 His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala Tyr His Ser 4205 4210 4215 gac gtg atc gag gac gtc agc ggc gag ggt ctg ctc gag tgc cac 23310 Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu Cys His 4220 4225 4230 tgc cgc tgc aac ctc tgc acg ccg cac cgc tcc ctg gcc tgc aac 23355 Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys Asn 4235 4240 4245 ccc cag ctg ctg agc gag acc cag atc atc ggc acc ttc gag ttg 23400 Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu 4250 4255 4260 caa ggc ccc ggc gag gag ggc aag ggg ggt ctg aaa ctc acc ccg 23445 Gln Gly Pro Gly Glu Glu Gly Lys Gly Gly Leu Lys Leu Thr Pro 4265 4270 4275 ggg ctg tgg acc tcg gcc tac ttg cgc aag ttc gtg ccc gag gac 23490 Gly Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp 4280 4285 4290 tac cat ccc ttc gag atc agg ttc tac gag gac caa tcc cag ccg 23535 Tyr His Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro 4295 4300 4305 ccc aag gcc gag ctg tcg gcc tgc gtc atc acc cag ggg gcc atc 23580 Pro Lys Ala Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile 4310 4315 4320 ctg gcc caa ttg caa gcc atc cag aaa tcc cgc caa gaa ttt ctg 23625 Leu Ala Gln Leu Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu 4325 4330 4335 ctg aaa aag ggc cac ggg gtc tac ttg gac ccc cag acc gga gag 23670 Leu Lys Lys Gly His Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu 4340 4345 4350 gag ctc aac ccc agc ttc ccc cag gat gcc cag agg aag cag caa 23715 Glu Leu Asn Pro Ser Phe Pro Gln Asp Ala Gln Arg Lys Gln Gln 4355 4360 4365 gaa gct gaa agt gga gct gcc gct gcc gcc gga gga ttt gga gga 23760 Glu Ala Glu Ser Gly Ala Ala Ala Ala Ala Gly Gly Phe Gly Gly 4370 4375 4380 aga ctg gga gag cag tca ggc aga gga gga gga gat gga aga ctg 23805 Arg Leu Gly Glu Gln Ser Gly Arg Gly Gly Gly Asp Gly Arg Leu 4385 4390 4395 gga cag cac tca ggc aga gga gga cag cct gca aga cag tct gga 23850 Gly Gln His Ser Gly Arg Gly Gly Gln Pro Ala Arg Gln Ser Gly 4400 4405 4410 aga cga ggt gga gga ggc aga gga aga agc agc cgc cgc cag acc 23895 Arg Arg Gly Gly Gly Gly Arg Gly Arg Ser Ser Arg Arg Gln Thr 4415 4420 4425 gtc gtc ctc ggc gga gaa agc aag cag cac gga tac cat ctc cgc 23940 Val Val Leu Gly Gly Glu Ser Lys Gln His Gly Tyr His Leu Arg 4430 4435 4440 tcc ggg tcg ggg tct cgg cgg ccg ggc cca cag tagatgggac 23983 Ser Gly Ser Gly Ser Arg Arg Pro Gly Pro Gln 4445 4450 gagaccgggc gcttcccgaa ccccaccacc cagaccggta agaaggagcg gcagggatac 24043 aagtcctggc gggggcacaa aaacgccatc gtctcctgct tgcaagcctg cgggggcaac 24103 atctccttca cccggcgcta cctgctcttc caccgcgggg tgaacttccc ccgcaacatc 24163 ttgcattact accgtcacct ccacagcccc tactactgtt tccaagaaga ggcagaaacc 24223 cagcagcagc agaaaaccag cagcagctag aaaatccaca gcggcggcgg cggcaggtgg 24283 actgaggatc gcggcgaacg agccggcgca gacccgggag ctgaggaacc ggatctttcc 24343 caccctctat gccatcttcc agcagagtcg ggggcaggag caggaactga aagtcaagaa 24403 ccgttctctg cgctcgctca cccgcagttg tctgtatcac aagagcgaag accaacttca 24463 gcgcactctc gaggacgccg aggctctctt caacaagtac tgcgcgctca ctcttaaaga 24523 gtagcccgcg cccgcccaca cacggaaaaa ggcgggaatt acgtcaccac ctgcgccctt 24583 cgcccgacca tcatc atg agc aaa gag att ccc acg cct tac atg tgg 24631 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp 4455 4460 agc tac cag ccc cag atg ggc ctg gcc gcc ggc gcc gcc cag gac 24676 Ser Tyr Gln Pro Gln Met Gly Leu Ala Ala Gly Ala Ala Gln Asp 4465 4470 4475 tac tcc acc cgc atg aac tgg ctc agt gcc ggg ccc gcg atg atc 24721 Tyr Ser Thr Arg Met Asn Trp Leu Ser Ala Gly Pro Ala Met Ile 4480 4485 4490 tca cgg gtg aat gac atc cgc gcc cac cga aac cag ata ctc cta 24766 Ser Arg Val Asn Asp Ile Arg Ala His Arg Asn Gln Ile Leu Leu 4495 4500 4505 gaa cag tca gcg atc acc gcc acg ccc cgc cat cac ctt aat ccg 24811 Glu Gln Ser Ala Ile Thr Ala Thr Pro Arg His His Leu Asn Pro 4510 4515 4520 cgt aat tgg ccc gcc gcc ctg gtg tac cag gaa att ccc cag ccc 24856 Arg Asn Trp Pro Ala Ala Leu Val Tyr Gln Glu Ile Pro Gln Pro 4525 4530 4535 acg acc gta cta ctt ccg cga gac gcc cag gcc gaa gtc cag ctg 24901 Thr Thr Val Leu Leu Pro Arg Asp Ala Gln Ala Glu Val Gln Leu 4540 4545 4550 act aac tca ggt gtc cag ctg gcc ggc ggc gcc gcc ctg tgt cgt 24946 Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala Ala Leu Cys Arg 4555 4560 4565 cac cgc ccc gct cag ggt ata aag cgg ctg gtg atc cga ggc aga 24991 His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile Arg Gly Arg 4570 4575 4580 ggc aca cag ctc aac gac gag gtg gtg agc tct tcg ctg ggt ctg 25036 Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu Gly Leu 4585 4590 4595 cga cct gac gga gtc ttc caa ctc gcc gga tcg ggg aga tct tcc 25081 Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser Ser 4600 4605 4610 ttc acg cct cgt cag gcc gtc ctg act ttg gag agt tcg tcc tcg 25126 Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 4615 4620 4625 cag ccc cgc tcg ggt ggc atc ggc act ctc cag ttc gtg gag gag 25171 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu 4630 4635 4640 ttc act ccc tcg gtc tac ttc aac ccc ttc tcc ggc tcc ccc ggc 25216 Phe Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly 4645 4650 4655 cac tac ccg gac gag ttc atc ccg aac ttc gac gcc atc agc gag 25261 His Tyr Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu 4660 4665 4670 tcg gtg gac ggc tac gat tga atg tcc cat ggt ggc gcg gct gac 25306 Ser Val Asp Gly Tyr Asp Met Ser His Gly Gly Ala Ala Asp 4675 4680 4685 cta gct cgg ctt cga cac ctg gac cac tgc cgc cgc ttc cgc tgc 25351 Leu Ala Arg Leu Arg His Leu Asp His Cys Arg Arg Phe Arg Cys 4690 4695 4700 ttc gct cgg gat ctc gcc gag ttt gcc tac ttt gag ctg ccc gag 25396 Phe Ala Arg Asp Leu Ala Glu Phe Ala Tyr Phe Glu Leu Pro Glu 4705 4710 4715 gag cac cct cag ggc ccg gcc cac gga gtg cgg atc atc gtc gaa 25441 Glu His Pro Gln Gly Pro Ala His Gly Val Arg Ile Ile Val Glu 4720 4725 4730 ggg ggc ctc gac tcc cac ctg ctt cgg atc ttc agc cag cgt ccg 25486 Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe Ser Gln Arg Pro 4735 4740 4745 atc ctg gtc gag cgc gag caa gga cag acc cgt ctg acc ctg tac 25531 Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Arg Leu Thr Leu Tyr 4750 4755 4760 tgc atc tgc aac cac ccc ggc ctg cat gaa agt ctt tgt tgt ctg 25576 Cys Ile Cys Asn His Pro Gly Leu His Glu Ser Leu Cys Cys Leu 4765 4770 4775 ctg tgt act gag tat aat aaa agc tgagatcagc gactactccg 25620 Leu Cys Thr Glu Tyr Asn Lys Ser 4780 4785 gacttccgtg tgttcctgaa tccatcaacc agtccctgtt cttcaccggg aacgagaccg 25680 agctccagct ccagtgtaag ccccacaaga agtacctcac ctggctgttc cagggctccc 25740 cgatcgccgt tgtcaaccac tgcgacaacg acggagtcct gctgagcggc cctgccaacc 25800 ttactttttc cacccgcaga agcaagctcc agctcttcca acccttcctc cccgggacct 25860 atcagtgcgt ctcgggaccc tgccatcaca ccttccacct gatcccgaat accacagcgt 25920 cgctccccgc tactaacaac caaactaccc accaacgcca ccgtcgcgac ctttcctctg 25980 aatctaatac cactaccgga ggtgagctcc gaggtcgacc aacctctggg atttactacg 26040 gcccctggga ggtggtgggg ttaatagcgc taggcctagt tgtgggtggg cttttggctc 26100 tctgctacct atacctccct tgctgttcgt acttagtggt gctgtgttgc tggtttaaga 26160 a atg ggg cag atc acc cta gtg agc tgc ggt gtg ctg gtg gcg gtg 26206 Met Gly Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val 4790 4795 4800 gtg ctt tcg att gtg gga ctg ggc ggc gcg gct gta gtg aag gag 26251 Val Leu Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu 4805 4810 4815 aag gcc gat ccc tgc ttg cat ttc aat ccc gat aaa tgc cag ctg 26296 Lys Ala Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu 4820 4825 4830 agt ttt cag ccc gat ggc aat cgg tgc gcg gtg ctg atc aag tgc 26341 Ser Phe Gln Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys 4835 4840 4845 gga tgg gaa tgc gag aac gtg aga atc gag tac aat aac aag act 26386 Gly Trp Glu Cys Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr 4850 4855 4860 cgg aac aat act ctc gcg tcc acg tgg cag ccc ggg gac ccc gag 26431 Arg Asn Asn Thr Leu Ala Ser Thr Trp Gln Pro Gly Asp Pro Glu 4865 4870 4875 tgg tac acc gtc tct gtc ccc ggt gct gac ggc tcc ccg cgc acc 26476 Trp Tyr Thr Val Ser Val Pro Gly Ala Asp Gly Ser Pro Arg Thr 4880 4885 4890 gtg aat aat act ttc att ttt gcg cac atg tgc gac acg gtc atg 26521 Val Asn Asn Thr Phe Ile Phe Ala His Met Cys Asp Thr Val Met 4895 4900 4905 tgg atg agc aag cag tac gat atg tgg ccc ccc acg aag gag aac 26566 Trp Met Ser Lys Gln Tyr Asp Met Trp Pro Pro Thr Lys Glu Asn 4910 4915 4920 atc gtg gtc ttc tcc atc gct tac agc ctg tgc acg gtg cta atc 26611 Ile Val Val Phe Ser Ile Ala Tyr Ser Leu Cys Thr Val Leu Ile 4925 4930 4935 acc gct atc gtg tgc ctg agc att cac atg ctc atc gct att cgc 26656 Thr Ala Ile Val Cys Leu Ser Ile His Met Leu Ile Ala Ile Arg 4940 4945 4950 ccc aga aat aat gcc gaa aaa gaa aaa cag cca taacacgttt 26699 Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 4955 4960 tttcacacac ctttttcaga cc atg gcc tct gtt aaa ttt ttg ctt tta 26748 Met Ala Ser Val Lys Phe Leu Leu Leu 4965 4970 ttt gcc agt ctc att act gtt ata agt aat gag aaa ctc act att 26793 Phe Ala Ser Leu Ile Thr Val Ile Ser Asn Glu Lys Leu Thr Ile 4975 4980 4985 tac att ggc act aac cac act cta gaa gga att cca aaa tcc tca 26838 Tyr Ile Gly Thr Asn His Thr Leu Glu Gly Ile Pro Lys Ser Ser 4990 4995 5000 tgg tat tgc tat ttt gat caa gat cca gac tta act ata gaa ctg 26883 Trp Tyr Cys Tyr Phe Asp Gln Asp Pro Asp Leu Thr Ile Glu Leu 5005 5010 5015 tgt ggt aac aag gga caa aat aca agc att cat tta att aac ttt 26928 Cys Gly Asn Lys Gly Gln Asn Thr Ser Ile His Leu Ile Asn Phe 5020 5025 5030 aaa tgc gga gac gat ttg aaa tta att aat atc act aaa gag tat 26973 Lys Cys Gly Asp Asp Leu Lys Leu Ile Asn Ile Thr Lys Glu Tyr 5035 5040 5045 gga ggt atg tat tac tat gtt aca gaa aat aac aac atg cag ttt 27018 Gly Gly Met Tyr Tyr Tyr Val Thr Glu Asn Asn Asn Met Gln Phe 5050 5055 5060 tat gaa gtt act gta act aat ccc acc acg cct aga aca aca aca 27063 Tyr Glu Val Thr Val Thr Asn Pro Thr Thr Pro Arg Thr Thr Thr 5065 5070 5075 acc acc aca aag act aca cct gtt acc act atg cag ctc act acc 27108 Thr Thr Thr Lys Thr Thr Pro Val Thr Thr Met Gln Leu Thr Thr 5080 5085 5090 aat aac att ttt gcc atg cgt cag aag gcc aac aat agc acc agc 27153 Asn Asn Ile Phe Ala Met Arg Gln Lys Ala Asn Asn Ser Thr Ser 5095 5100 5105 att caa ccc ccc cca ccc agt gag gaa att ccc aaa tcc atg att 27198 Ile Gln Pro Pro Pro Pro Ser Glu Glu Ile Pro Lys Ser Met Ile 5110 5115 5120 ggc att att gtt gct gta gtg gtg tgc atg ttg atc atc gcc ttg 27243 Gly Ile Ile Val Ala Val Val Val Cys Met Leu Ile Ile Ala Leu 5125 5130 5135 tgc atg gtg tac tat gcc ttc tgc tac aga aag cac aga ctg aac 27288 Cys Met Val Tyr Tyr Ala Phe Cys Tyr Arg Lys His Arg Leu Asn 5140 5145 5150 gac aag cta gaa cac tta cta agt gtt gaa ttt taattttttt agaacc 27337 Asp Lys Leu Glu His Leu Leu Ser Val Glu Phe 5155 5160 atg aag atc cta ggc ctt tta att ttt tct atc att acc tct gct 27382 Met Lys Ile Leu Gly Leu Leu Ile Phe Ser Ile Ile Thr Ser Ala 5165 5170 5175 cta tgc aat tct gac aat gag gac gtt act gtc gtt gtc gga tca 27427 Leu Cys Asn Ser Asp Asn Glu Asp Val Thr Val Val Val Gly Ser 5180 5185 5190 aat tat aca ctg aaa ggt cca gcg aag ggt atg ctt tcg tgg tat 27472 Asn Tyr Thr Leu Lys Gly Pro Ala Lys Gly Met Leu Ser Trp Tyr 5195 5200 5205 tgc tgg ttt gga act gac act gaa caa acc gaa tta tgc aat ctt 27517 Cys Trp Phe Gly Thr Asp Thr Glu Gln Thr Glu Leu Cys Asn Leu 5210 5215 5220 caa aat ggc aaa gtt cat aat tct aaa att tac aat tat ata tgc 27562 Gln Asn Gly Lys Val His Asn Ser Lys Ile Tyr Asn Tyr Ile Cys 5225 5230 5235 aat ggc act gat ttg ata ctc ctc aat atc acg aaa tca tat gct 27607 Asn Gly Thr Asp Leu Ile Leu Leu Asn Ile Thr Lys Ser Tyr Ala 5240 5245 5250 ggc agt tat tca tgc cct gga gat gat gct gac aat atg att ttt 27652 Gly Ser Tyr Ser Cys Pro Gly Asp Asp Ala Asp Asn Met Ile Phe 5255 5260 5265 tat aaa ttg caa gtg gtt gat ccc act act cca cct cca ccc acc 27697 Tyr Lys Leu Gln Val Val Asp Pro Thr Thr Pro Pro Pro Pro Thr 5270 5275 5280 aca act act cac acc aca cac aca gaa caa acc aca gca gag gag 27742 Thr Thr Thr His Thr Thr His Thr Glu Gln Thr Thr Ala Glu Glu 5285 5290 5295 gcg gca aag tta gct ttg cag gtc caa gac agt tca ttt gtt ggc 27787 Ala Ala Lys Leu Ala Leu Gln Val Gln Asp Ser Ser Phe Val Gly 5300 5305 5310 att acc cct aca ccc gat cag cgg tgt ccg ggg ctg ctc gtc agc 27832 Ile Thr Pro Thr Pro Asp Gln Arg Cys Pro Gly Leu Leu Val Ser 5315 5320 5325 ggc att gtc ggt gtg ctt tcg gga tta gca gtt ata atc atc tgc 27877 Gly Ile Val Gly Val Leu Ser Gly Leu Ala Val Ile Ile Ile Cys 5330 5335 5340 atg ttc att ttt gct tgc tgc tat aga agg ctt tac cga caa aaa 27922 Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr Arg Gln Lys 5345 5350 5355 tca gac cca ctg ctg aac ctc tat gtt taattttttc cagagccatg 27969 Ser Asp Pro Leu Leu Asn Leu Tyr Val 5360 5365 aaggcagtta gcgctctagt tttttgttct ttgattggca ctgtttttag tgttagcttt 28029 ttaaaacaaa ttaatgttac tgagggggaa aatgtgacac tggtaggcgt agaaggtgct 28089 caaaatacca cctggacaaa ataccacctc gatgggtgga aagatatttg caattggagt 28149 gtcattactt acacatgtga gggagttaat ttgaccatag tcaatgccag ccaaaatcag 28209 aagggttgga ttaaagggca atctgttagt gttaccagtg aggggtacta tacccagcat 28269 actcttatct atgacattat agtcataccg ctgcctacgc ctagcccacc tagcactacc 28329 acacagacaa cccacactac acaaacaacc acatacagta catcaaatca gcctaccacc 28389 actacaacag cagaggttgc cagctcgtct ggggtccgag cggcattttt gatgttggcc 28449 ccatctagca gtcccactgc tagtaccaat gagcagacta ctgaattttt gtccactgtc 28509 gagagccaca ccacagctac ctcgagtgcc ttctctagca ccgccaatct ctcctcgctt 28569 tcctctacac caatcagtcc cgctactact actacccccg ctattcttcc cactcccctg 28629 aagcaaactg aggacagcgg catgcaatgg cagatcaccc tgctcattgt gatcgggttg 28689 gtcatcctag ccgtgttgct ctactacatc ttccgccgcc gcattcccaa cgcgcaccgc 28749 aagccggtct acaagcccat cattgtcggg cagccggagc cgcttcaggt ggaagggggt 28809 ctaaggaatc ttctcttctc ttttacagta tggtgattga actatgattc ctagacaatt 28869 cttgatcact attcttatct gcctcctcca agtctgtgcc accctcgctc tggtggccaa 28929 cgccagtcca gactgtattg ggcccttcgc ctcctacgtg ctctttgcct tcatcacctg 28989 catctgctgc tgtagcatag tctgcctgct tatcaccttc ttccagttca ttgactggat 29049 ctttgtgcgc atcgcctacc tgcgccacca cccccagtac cgcgaccagc gagtggcgca 29109 gctgctcagg ctcctctgat aagc atg cgg gct ctg cta ctt ctc gcg ctt 29160 Met Arg Ala Leu Leu Leu Leu Ala Leu 5370 ctg ctg tta gtg ctc ccc cgt ccc gtt gac ccc cgg ccc ccc act 29205 Leu Leu Leu Val Leu Pro Arg Pro Val Asp Pro Arg Pro Pro Thr 5375 5380 5385 cag tcc ccc gag gag gtc cgc aaa tgc aaa ttc caa gaa ccc tgg 29250 Gln Ser Pro Glu Glu Val Arg Lys Cys Lys Phe Gln Glu Pro Trp 5390 5395 5400 aaa ttc ctc aaa tgc tac cgc caa aaa tca gac atg cat ccc agc 29295 Lys Phe Leu Lys Cys Tyr Arg Gln Lys Ser Asp Met His Pro Ser 5405 5410 5415 tgg atc atg atc att ggg atc gtg aac att ctg gcc tgc acc ctc 29340 Trp Ile Met Ile Ile Gly Ile Val Asn Ile Leu Ala Cys Thr Leu 5420 5425 5430 atc tcc ttt gtg att tac ccc tgc ttt gac ttt ggt tgg aac tcg 29385 Ile Ser Phe Val Ile Tyr Pro Cys Phe Asp Phe Gly Trp Asn Ser 5435 5440 5445 cca gag gcg ctc tat ctc ccg cct gaa cct gac aca cca cca cag 29430 Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr Pro Pro Gln 5450 5455 5460 caa cct cag gca cac gca cta cca cca cca cag cct agg cca caa 29475 Gln Pro Gln Ala His Ala Leu Pro Pro Pro Gln Pro Arg Pro Gln 5465 5470 5475 tac atg ccc ata tta gac tat gag gcc gag cca cag cga ccc atg 29520 Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg Pro Met 5480 5485 5490 ctc ccc gct att agt tac ttc aat cta acc ggc gga gat gac 29562 Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 5495 5500 5505 tgacccactg gccaacaaca acgtcaacga ccttctcctg gacatggacg gccgcgcctc 29622 ggagcagcga ctcgcccaac ttcgcattcg ccagcagcag gagagagccg tcaaggagct 29682 gcaggacggc atagccatcc accagtgcaa gaaaggcatc ttctgcctgg tgaaacaggc 29742 caagatctcc tacgaggtca cccagaccga ccatcgcctc tcctacgagc tcctgcagca 29802 gcgccagaag ttcacctgcc tggtcggagt caaccccatc gtcatcaccc agcagtcggg 29862 cgataccaag gggtgcatcc actgctcctg cgactccccc gactgcgtcc acactctgat 29922 caagaccctc tgcggcctcc gcgacctcct ccccatgaac taatcacccc cttatccagt 29982 gaaataaaga tcatattgat gattaaataa aaaaaataat catttgattt gaaataaaga 30042 tacaatcata ttgatgattt gagtttaata aaaataaaga atcacttact tgaaatctga 30102 taccaggtct ctgtccatgt tttctgccaa caccacttca ctcccctctt cccagctctg 30162 gtactgcagg ccccggcggg ctgcaaactt cctccacacc ctgaagggga tgtcaaattc 30222 ctcctgtccc tcaatcttca ttttatcttc tatcag atg tcc aaa aag cgc gtc 30276 Met Ser Lys Lys Arg Val 5510 cgg gtg gat gat gac ttc gac ccc gtc tac ccc tac gat gca gac 30321 Arg Val Asp Asp Asp Phe Asp Pro Val Tyr Pro Tyr Asp Ala Asp 5515 5520 5525 aac gca ccg acc gtg ccc ttc atc aac ccc ccc ttc gtc tct tca 30366 Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro Phe Val Ser Ser 5530 5535 5540 gat gga ttc caa gag aag ccc ctg ggg gtg ctg tcc ctg cgt ctg 30411 Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser Leu Arg Leu 5545 5550 5555 gcc gat ccc gtc acc acc aag aac ggg gaa atc acc ctc aag ctg 30456 Ala Asp Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu Lys Leu 5560 5565 5570 gga gat ggg gtg gac ctc gac tcc tcg gga aaa ctc atc tcc aac 30501 Gly Asp Gly Val Asp Leu Asp Ser Ser Gly Lys Leu Ile Ser Asn 5575 5580 5585 acg gcc acc aag gcc gcc gcc cct ctc agt ttt tcc aac aac acc 30546 Thr Ala Thr Lys Ala Ala Ala Pro Leu Ser Phe Ser Asn Asn Thr 5590 5595 5600 att tcc ctt aac atg gat acc cct ttt tac aac aac aat gga aag 30591 Ile Ser Leu Asn Met Asp Thr Pro Phe Tyr Asn Asn Asn Gly Lys 5605 5610 5615 tta ggc atg aaa gtc act gct cca ctg aag ata cta gac aca gac 30636 Leu Gly Met Lys Val Thr Ala Pro Leu Lys Ile Leu Asp Thr Asp 5620 5625 5630 ttg cta aaa aca ctt gtt gta gct tat gga caa ggt tta gga aca 30681 Leu Leu Lys Thr Leu Val Val Ala Tyr Gly Gln Gly Leu Gly Thr 5635 5640 5645 aac acc act ggt gcc ctt gtt gcc caa cta gca tcc cca ctt gct 30726 Asn Thr Thr Gly Ala Leu Val Ala Gln Leu Ala Ser Pro Leu Ala 5650 5655 5660 ttt gat agc aat agc aaa att gcc ctt aat tta ggc aat gga cca 30771 Phe Asp Ser Asn Ser Lys Ile Ala Leu Asn Leu Gly Asn Gly Pro 5665 5670 5675 ttg aaa gtg gat gca aat aga ctg aac atc aat tgc aat aga gga 30816 Leu Lys Val Asp Ala Asn Arg Leu Asn Ile Asn Cys Asn Arg Gly 5680 5685 5690 ctc tat gtt act acc aca aaa gat gca ctg gaa gcc aat ata agt 30861 Leu Tyr Val Thr Thr Thr Lys Asp Ala Leu Glu Ala Asn Ile Ser 5695 5700 5705 tgg gct aat gct atg aca ttt ata gga aat gcc atg ggt gtc aat 30906 Trp Ala Asn Ala Met Thr Phe Ile Gly Asn Ala Met Gly Val Asn 5710 5715 5720 att gat aca caa aaa ggc ttg caa ttt ggc acc act agt acc gtc 30951 Ile Asp Thr Gln Lys Gly Leu Gln Phe Gly Thr Thr Ser Thr Val 5725 5730 5735 gca gat gtt aaa aac gct tac ccc ata caa atc aaa ctt gga gct 30996 Ala Asp Val Lys Asn Ala Tyr Pro Ile Gln Ile Lys Leu Gly Ala 5740 5745 5750 ggt ctc aca ttt gac agc aca ggt gca att gtt gca tgg aac aaa 31041 Gly Leu Thr Phe Asp Ser Thr Gly Ala Ile Val Ala Trp Asn Lys 5755 5760 5765 gat gat gac aag ctt aca cta tgg acc aca gcc gac ccc tct cca 31086 Asp Asp Asp Lys Leu Thr Leu Trp Thr Thr Ala Asp Pro Ser Pro 5770 5775 5780 aat tgt cac ata tat tct gaa aag gat gct aag ctt aca ctt tgc 31131 Asn Cys His Ile Tyr Ser Glu Lys Asp Ala Lys Leu Thr Leu Cys 5785 5790 5795 ttg aca aag tgt ggc agt cag att ctg ggc act gtt tcc ctc ata 31176 Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Ser Leu Ile 5800 5805 5810 gct gtt gat act ggc agt tta aat ccc ata aca gga aca gta acc 31221 Ala Val Asp Thr Gly Ser Leu Asn Pro Ile Thr Gly Thr Val Thr 5815 5820 5825 act gct ctt gtc tca ctt aaa ttc gat gca aat gga gtt ttg caa 31266 Thr Ala Leu Val Ser Leu Lys Phe Asp Ala Asn Gly Val Leu Gln 5830 5835 5840 agc agc tca aca cta gac tca gac tat tgg aat ttc aga cag gga 31311 Ser Ser Ser Thr Leu Asp Ser Asp Tyr Trp Asn Phe Arg Gln Gly 5845 5850 5855 gat gtt aca cct gct gaa gcc tat act aat gct ata ggt ttc atg 31356 Asp Val Thr Pro Ala Glu Ala Tyr Thr Asn Ala Ile Gly Phe Met 5860 5865 5870 ccc aat cta aaa gca tac cct aaa aac aca agt gga gct gca aaa 31401 Pro Asn Leu Lys Ala Tyr Pro Lys Asn Thr Ser Gly Ala Ala Lys 5875 5880 5885 agt cac att gtt ggg aaa gtg tac cta cat ggg gat aca gac aaa 31446 Ser His Ile Val Gly Lys Val Tyr Leu His Gly Asp Thr Asp Lys 5890 5895 5900 cca ctg gac ctc att att act ttc aat gaa aca agt gat gaa tct 31491 Pro Leu Asp Leu Ile Ile Thr Phe Asn Glu Thr Ser Asp Glu Ser 5905 5910 5915 tgc act tac tgt att aac ttt caa tgg cag tgg ggg gct gat caa 31536 Cys Thr Tyr Cys Ile Asn Phe Gln Trp Gln Trp Gly Ala Asp Gln 5920 5925 5930 tat aaa aat gaa aca ctt gcc gtc agt tca ttc acc ttt tcc tat 31581 Tyr Lys Asn Glu Thr Leu Ala Val Ser Ser Phe Thr Phe Ser Tyr 5935 5940 5945 att gct aaa gaa taaaccccac tctgtacccc atctctgtct atggaaaaaa 31633 Ile Ala Lys Glu 5950 ctctgaaaca caaaataaaa taaagttcaa gtgttttatt gattcaacag ttttacagga 31693 ttcgagcagt tatttttcct ccaccctccc aggacatgga atacaccacc ctctcccccc 31753 gcacagcctt gaacatctga atgccattgg tgatggacat gcttttggtc tccacgttcc 31813 acacagtttc agagcgagcc agtctcgggt cggtcaggga gatgaaaccc tccgggcact 31873 cccgcatctg cacctcacag ctcaacagct gaggattgtc ctcggtggtc gggatcacgg 31933 ttatctggaa gaagcagaag agcggcggtg ggaatcatag tccgcgaacg ggatcggccg 31993 gtggtgtcgc atcaggcccc gcagcagtcg ctgtcgccgc cgctccgtca agctgctgct 32053 cagggggtcc gggtccaggg actccctcag catgatgccc acggccctca gcatcagtcg 32113 tctggtgcgg cgggcgcagc agcgcatgcg gatctcgctc aggtcgctgc agtacgtgca 32173 acacaggacc accaggttgt tcaacagtcc atagttcaac acgctccagc cgaaactcat 32233 cgcgggaagg atgctaccca cgtggccgtc gtaccagatc ctcaggtaaa tcaagtggcg 32293 ccccctccag aacacgctgc ccatgtacat gatctccttg ggcatgtggc ggttcaccac 32353 ctcccggtac cacatcaccc tctggttgaa catgcagccc cggatgatcc tgcggaacca 32413 cagggccagc accgccccgc ccgccatgca gcgaagagac cccgggtccc gacaatggca 32473 atggaggacc caccgctcgt acccgtggat catctgggag ctgaacaagt ctatgttggc 32533 acagcacagg catatgctca tgcatctctt cagcactctc agctcctcgg gggtcaaaac 32593 catatcccag ggcacgggga actcttgcag gacagcgaac cccgcagaac agggcaatcc 32653 tcgcacataa cttacattgt gcatggacag ggtatcgcaa tcaggcagca ccgggtgatc 32713 ctccaccaga gaagcgcggg tctcggtctc ctca cag cgt ggt aag ggg gcc 32765 Gln Arg Gly Lys Gly Ala 5955 ggc cga tac ggg tga tgg cgg gac gcg gct gat cgt gtt cgc gac 32810 Gly Arg Tyr Gly Trp Arg Asp Ala Ala Asp Arg Val Arg Asp 5960 5965 5970 cgt gtc atg atg cag ttg ctt tcg gac att ttc gta ctt gct gta 32855 Arg Val Met Met Gln Leu Leu Ser Asp Ile Phe Val Leu Ala Val 5975 5980 5985 gca gaa cct ggt ccg ggc gct gca cac cga tcg ccg gcg gcg gtc 32900 Ala Glu Pro Gly Pro Gly Ala Ala His Arg Ser Pro Ala Ala Val 5990 5995 6000 ccg gcg ctt gga acg ctc ggt gtt gaa gtt gta aaa cag cca ctc 32945 Pro Ala Leu Gly Thr Leu Gly Val Glu Val Val Lys Gln Pro Leu 6005 6010 6015 tct cag acc gtg cag cag atc tag ggc ctc agg agt gat gaa gat 32990 Ser Gln Thr Val Gln Gln Ile Gly Leu Arg Ser Asp Glu Asp 6020 6025 6030 ccc atc atg cct gat ggc tct aat cac atc gac cac cgt gga atg 33035 Pro Ile Met Pro Asp Gly Ser Asn His Ile Asp His Arg Gly Met 6035 6040 6045 ggc cag acc cag cca gat gat gca att ttg ttg ggt ttc ggt gac 33080 Gly Gln Thr Gln Pro Asp Asp Ala Ile Leu Leu Gly Phe Gly Asp 6050 6055 6060 ggc ggg gga ggg aag aac agg aag aac cat gattaacttt taatccaaac 33130 Gly Gly Gly Gly Lys Asn Arg Lys Asn His 6065 6070 ggtctcggag cacttcaaaa tgaagatcgc ggagatggca cctctcgccc ccgctgtgtt 33190 ggtggaaaat aacagccagg tcaaaggtga tacggttctc gagatgttcc acggtggctt 33250 ccagcaaagc ctccacgcgc acatccagaa acaagacaat agcgaaagcg ggagggttct 33310 ctaattcctc aatcatcatg ttacactcct gcaccatccc cagataattt tcatttttcc 33370 agccttgaat gattcgaact agttcctgag gtaaatccaa gccagccatg ataaagagct 33430 cgcgcagagc gccctccacc ggcattctta agcacaccct cataattcca agatattctg 33490 ctcctggttc acctgcagca gattgacaag cggaatatca aaatctctgc cgcgatccct 33550 aagctcctcc ctcagcaata actgtaagta ctctttcata tcctctccga aatttttagc 33610 cataggaccg ccaggaatga gattaggaca agccacatta cagataaacc gaagtccccc 33670 ccagtgagca ttgccaaatg taagattgaa ataagcatgc tggctagacc cggtgatatc 33730 ttccagataa ctggacagaa aatcgcccag gcaattttta agaaaatcaa caaaagaaaa 33790 atcttccagg tgcacgttta gggcctcggg aacaacgatg gagtaagtgc aaggggtgcg 33850 ttccagcatg gttagttagc tgatctgtaa aaaaacaaaa aataaaacat taaaccatgc 33910 tagcctggcg aacaggtggg taaatcgttc tctccagcac caggcaggcc acggggtctc 33970 cggcgcgacc ctcgtaaaaa ttgtcgctat gattgaaaac catcacagag agacgttccc 34030 ggtggccggc gtgaatgatt cgacaagatg aatacacccc cggaacattg gcgtccgcga 34090 gtgaaaaaaa gcggccgagg aagcaataag gcactacaat gctcagtctc aagtccagca 34150 aagcgatgcc atgcggatga agcacaaaat tctcaggtgc gtacaaaatg taattactcc 34210 cctcctgcac aggcagcaaa gccccagatc cctccagata cacatacaaa gcctcagcgt 34270 ccatagctta ccgagcagca gcacacaaca ggcgcaagag tcagagaaag gctgagctct 34330 aacctgtccc ccgctctctg ctcaatatat agcccagatc tacactgacg taaaggccaa 34390 agtctaaaaa tacccgccaa ataatcacac acgcccagca cacgcccaga aaccggtgac 34450 acactcaaaa aaatacgcgc acttcctcaa acgcccaaac tgccgtcatt tccgggttcc 34510 cacgctacgt catcagaatt cgactttcaa atccgtcgac cgttaaacac gtcactcgcc 34570 ccgcccctaa cggtcgccct cctctcggcc aatcacagcc ccgcatcccc aaattcaaac 34630 gcctcatttg catattaacg cgcacaaaaa gtttgaggta tattattgat gatgatcgtt 34690 taaactatgc ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg catcaggcgc 34750 tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta 34810 tcagctcact caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag 34870 aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg 34930 tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg 34990 tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg 35050 cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga 35110 agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc 35170 tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt 35230 aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact 35290 ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg 35350 cctaactacg gctacactag aaggacagta tttggtatct gcgctctgct gaagccagtt 35410 accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt 35470 ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct 35530 ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg 35590 gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt 35650 aaatcaatct aaagtatata tgagtaaact tggtctgaca g tta cca atg ctt 35703 Leu Pro Met Leu 6075 aat cag tga ggc acc tat ctc agc gat ctg tct att tcg ttc atc 35748 Asn Gln Gly Thr Tyr Leu Ser Asp Leu Ser Ile Ser Phe Ile 6080 6085 6090 cat agt tgc ctg act ccc cgt cgt gta gat aac tac gat acg gga 35793 His Ser Cys Leu Thr Pro Arg Arg Val Asp Asn Tyr Asp Thr Gly 6095 6100 6105 ggg ctt acc atc tgg ccc cag tgc tgc aat gat acc gcg aga ccc 35838 Gly Leu Thr Ile Trp Pro Gln Cys Cys Asn Asp Thr Ala Arg Pro 6110 6115 6120 acg ctc acc ggc tcc aga ttt atc agc aat aaa cca gcc agc cgg 35883 Thr Leu Thr Gly Ser Arg Phe Ile Ser Asn Lys Pro Ala Ser Arg 6125 6130 6135 aag ggc cga gcg cag aag tgg tcc tgc aac ttt atc cgc ctc cat 35928 Lys Gly Arg Ala Gln Lys Trp Ser Cys Asn Phe Ile Arg Leu His 6140 6145 6150 cca gtc tat taa ttg ttg ccg gga agc tag agt aag tag ttc gcc agt 35976 Pro Val Tyr Leu Leu Pro Gly Ser Ser Lys Phe Ala Ser 6155 6160 taa tag ttt gcg caa cgt tgt tgc cat tgc tgc agg cat cgt ggt 36021 Phe Ala Gln Arg Cys Cys His Cys Cys Arg His Arg Gly 6165 6170 6175 gtc acg ctc gtc gtt tgg tat ggc ttc att cag ctc cgg ttc cca 36066 Val Thr Leu Val Val Trp Tyr Gly Phe Ile Gln Leu Arg Phe Pro 6180 6185 6190 acg atc aag gcg agt tac atg atc ccc cat gtt gtg caa aaa agc 36111 Thr Ile Lys Ala Ser Tyr Met Ile Pro His Val Val Gln Lys Ser 6195 6200 6205 ggt tag ctc ctt cgg tcc tcc gat cgt tgt cag aag taa gtt ggc 36156 Gly Leu Leu Arg Ser Ser Asp Arg Cys Gln Lys Val Gly 6210 6215 cgc agt gtt atc act cat ggt tat ggc agc act gca taa ttc tct 36201 Arg Ser Val Ile Thr His Gly Tyr Gly Ser Thr Ala Phe Ser 6220 6225 6230 tac tgt cat gcc atc cgt aag atg ctt ttc tgt gac tgg tga gta 36246 Tyr Cys His Ala Ile Arg Lys Met Leu Phe Cys Asp Trp Val 6235 6240 6245 ctc aac caa gtc att ctg aga ata gtg tat gcg gcg acc gag ttg 36291 Leu Asn Gln Val Ile Leu Arg Ile Val Tyr Ala Ala Thr Glu Leu 6250 6255 6260 ctc ttg ccc ggc gtc aac acg gga taa tac cgc gcc aca tag cag 36336 Leu Leu Pro Gly Val Asn Thr Gly Tyr Arg Ala Thr Gln 6265 6270 6275 aac ttt aaa agt gct cat cat tgg aaa acg ttc ttc ggg gcg aaa 36381 Asn Phe Lys Ser Ala His His Trp Lys Thr Phe Phe Gly Ala Lys 6280 6285 6290 act ctc aag gat ctt acc gct gtt gag atc cag ttc gat gta acc 36426 Thr Leu Lys Asp Leu Thr Ala Val Glu Ile Gln Phe Asp Val Thr 6295 6300 6305 cac tcg tgc acc caa ctg atc ttc agc atc ttt tac ttt cac cag 36471 His Ser Cys Thr Gln Leu Ile Phe Ser Ile Phe Tyr Phe His Gln 6310 6315 6320 cgt ttc tgg gtg agc aaa aac agg aag gca aaa tgc cgc aaa aaa 36516 Arg Phe Trp Val Ser Lys Asn Arg Lys Ala Lys Cys Arg Lys Lys 6325 6330 6335 ggg aat aag ggc gac acg gaa atg ttg aat act cat act cttccttttt 36565 Gly Asn Lys Gly Asp Thr Glu Met Leu Asn Thr His Thr 6340 6345 caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt 36625 atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac 36685 gtctaagaaa ccattattat catgacatta acctataaaa ataggcgtat cacgaggccc 36745 tttcgtcttc aagaattgtt taaactac 36773 <210> 207 <211> 587 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 207 Met Gln Gln Gln Pro Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu 1 5 10 15 Gln Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala 20 25 30 Met Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg 35 40 45 Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val 50 55 60 Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn 65 70 75 80 Ala Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val 85 90 95 Tyr Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val 100 105 110 Gln Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ser 115 120 125 Gln Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala 130 135 140 Leu Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln 145 150 155 160 Glu Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Ala Glu 165 170 175 Val Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln 180 185 190 Thr Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys 195 200 205 Asn Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala 210 215 220 Thr Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu 225 230 235 240 Val Ala Pro Phe Thr Asp Ser Gly Ser Val Ser Arg Asp Ser Tyr Leu 245 250 255 Gly Tyr Leu Leu Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val 260 265 270 Asp Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly 275 280 285 Gln Glu Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr 290 295 300 Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu 305 310 315 320 Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met 325 330 335 Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn 340 345 350 Met Glu Pro Ser Met Tyr Ala Arg Asn Arg Pro Phe Ile Asn Lys Leu 355 360 365 Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr 370 375 380 Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr 385 390 395 400 Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp 405 410 415 Val Asp Ser Ser Val Phe Ser Pro Arg Pro Thr Thr Thr Val Trp Lys 420 425 430 Lys Glu Gly Gly Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly Arg Ala 435 440 445 Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu 450 455 460 Pro Phe Ser Leu Asn Ser Val Arg Ser Ser Glu Leu Gly Arg Leu Thr 465 470 475 480 Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu 485 490 495 Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu 500 505 510 Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala His Glu His Arg Asp 515 520 525 Glu Pro Arg Ala Ser Ser Ser Ala Gly Ala Thr Arg Arg Arg Gln Arg 530 535 540 His Asp Arg Gln Arg Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp 545 550 555 560 Asp Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe 565 570 575 Ala His Leu Arg Pro Arg Ile Gly Arg Leu Met 580 585 <210> 208 <211> 542 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 208 Met Met Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Val Ala Ala Ala Met Gln Pro Pro Leu Glu Ala 20 25 30 Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg Asn Ser 35 40 45 Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg Leu Tyr 50 55 60 Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr Gln Asn 65 70 75 80 Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp Phe Thr 85 90 95 Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg 100 105 110 Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro Asn Val 115 120 125 Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser 130 135 140 Arg Lys Thr Pro Asn Gly Val Thr Val Asp Glu Asn Tyr Asp Gly Ser 145 150 155 160 Gln Asp Glu Leu Thr Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly 165 170 175 Asn Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile 180 185 190 Asp Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp 195 200 205 Ile Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro 210 215 220 Val Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His 225 230 235 240 Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser 245 250 255 Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu 260 265 270 Gly Phe Gln Ile Leu Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala 275 280 285 Leu Leu Asp Val Glu Ala Tyr Glu Lys Ser Lys Glu Glu Ala Ala Ala 290 295 300 Ala Ala Thr Ala Ala Val Ala Thr Ala Ala Thr Thr Asp Ala Asp Ala 305 310 315 320 Ala Thr Thr Thr Arg Gly Asp Thr Phe Ala Thr Gln Ala Glu Glu Ala 325 330 335 Ala Ala Leu Ala Ala Thr Asp Asp Ser Glu Ser Lys Ile Val Ile Lys 340 345 350 Pro Val Glu Lys Asp Ser Lys Asp Arg Ser Tyr Asn Val Leu Ser Asp 355 360 365 Gly Lys Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly 370 375 380 Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp 385 390 395 400 Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met 405 410 415 Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn Tyr Pro 420 425 430 Val Val Gly Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser Phe Phe Asn 435 440 445 Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Ala Phe Thr Ser Leu Thr 450 455 460 His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Val Arg Pro Pro 465 470 475 480 Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp 485 490 495 His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val 500 505 510 Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala 515 520 525 Leu Gly Val Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 530 535 540 <210> 209 <211> 194 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 209 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Ala Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ser 130 135 140 Ser Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala 145 150 155 160 Ala Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val 165 170 175 Arg Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro 180 185 190 Arg Thr <210> 210 <211> 348 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 210 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys Glu Glu Arg Lys Pro Arg 20 25 30 Lys Leu Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Glu Asp Asp Gly 35 40 45 Leu Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp 50 55 60 Arg Gly Arg Lys Val Lys Pro Val Leu Arg Pro Gly Thr Thr Val Val 65 70 75 80 Phe Thr Pro Gly Glu Arg Ser Gly Ser Ala Ser Lys Arg Ser Tyr Asp 85 90 95 Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu 100 105 110 Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Pro Ala Pro Leu Lys Glu 115 120 125 Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu 130 135 140 Lys Pro Val Thr Leu Gln Gln Val Leu Pro Ser Ala Ala Pro Arg Arg 145 150 155 160 Gly Phe Lys Arg Glu Gly Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu 165 170 175 Met Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu His Met Lys 180 185 190 Val Asp Pro Glu Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln 195 200 205 Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr 210 215 220 Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr 225 230 235 240 Met Glu Val Gln Thr Asp Pro Trp Met Pro Ala Pro Ala Ser Thr Thr 245 250 255 Thr Thr Thr Arg Arg Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met 260 265 270 Pro Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg 275 280 285 Gly Thr Arg Phe Tyr Arg Gly Tyr Ser Ser Arg Arg Lys Thr Thr Thr 290 295 300 Arg Arg Arg Arg Arg Arg Thr Arg Arg Ser Thr Thr Ala Thr Ser Ala 305 310 315 320 Ala Ala Leu Val Arg Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu Thr 325 330 335 Leu Pro Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 340 345 <210> 211 <211> 77 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 211 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly Asn Gly Leu Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 212 <211> 244 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 212 Met Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg 1 5 10 15 Pro Phe Met Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly 20 25 30 Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly 35 40 45 Ser Thr Leu Lys Thr Tyr Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly 50 55 60 Gln Ala Leu Arg Asp Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val 65 70 75 80 Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn 85 90 95 Gln Ala Val Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro 100 105 110 Ala Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu 115 120 125 Asp Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu 130 135 140 Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu 145 150 155 160 Gly Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu 165 170 175 Lys Pro Glu Ser Asn Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Gln 180 185 190 Pro Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val 195 200 205 Ala Arg Ala Arg Pro Gly Gly Ser Ala Arg Pro His Ala Asn Trp Gln 210 215 220 Ser Thr Leu Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg 225 230 235 240 Arg Arg Cys Tyr <210> 213 <211> 943 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 213 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Ser Ser Gln Trp Glu Arg Ala Lys Thr Asn Asn Asn Gly 130 135 140 Ala Thr Glu Ser Val Thr Phe Gly Val Ala Ala Met Gly Gly Ile Asp 145 150 155 160 Ile Thr Lys Glu Gly Leu Gln Ile Gly Thr Asp Glu Thr Lys Ala Asp 165 170 175 Ser Lys Glu Ile Tyr Ala Asp Lys Thr Tyr Gln Pro Glu Pro Gln Ile 180 185 190 Gly Glu Glu Asn Trp Gln Glu Thr Phe Ser Tyr Tyr Gly Gly Arg Ala 195 200 205 Leu Lys Lys Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys 210 215 220 Pro Thr Asn Val Lys Gly Gly Gln Ala Lys Phe Lys Val Gln Asp Gly 225 230 235 240 Gln Gln Thr Thr Glu Tyr Asp Ile Asp Leu Ala Phe Phe Asp Ile Pro 245 250 255 Asn Ser Gly Thr Gly Gly Asn Gly Thr Asn Val Asn Tyr Asp Pro Asp 260 265 270 Met Val Met Tyr Thr Glu Asn Val Asp Leu Glu Thr Pro Asp Thr His 275 280 285 Ile Val Tyr Lys Pro Gly Thr Ser Asp Asp Ser Ser Glu Ala Asn Leu 290 295 300 Leu Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp 305 310 315 320 Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val 325 330 335 Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp 340 345 350 Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp 355 360 365 Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp 370 375 380 Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro 385 390 395 400 Asn Tyr Cys Phe Pro Leu Asp Gly Ala Gly Thr Asn Ala Val Tyr Gln 405 410 415 Gly Val Lys Ala Lys Thr Asn Gly Gly Ala Ala Asn Gly Asp Trp Glu 420 425 430 Gln Asp Thr Asp Val Ser Asn Ile Asn Gln Ile Cys Lys Gly Asn Ile 435 440 445 Tyr Ala Met Glu Ile Asn Leu Gln Ala Asn Leu Trp Arg Ser Phe Leu 450 455 460 Tyr Ser Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr Pro 465 470 475 480 Ala Asn Ile Thr Leu Pro Thr Asn Thr Asn Thr Tyr Asp Tyr Met Asn 485 490 495 Gly Arg Val Ala Pro Pro Ser Leu Val Asp Ala Tyr Ile Asn Ile Gly 500 505 510 Ala Arg Trp Ser Leu Asp Pro Met Asp Asn Val Asn Pro Phe Asn His 515 520 525 His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly 530 535 540 Arg Phe Val Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile 545 550 555 560 Lys Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe 565 570 575 Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu 580 585 590 Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala 595 600 605 Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met 610 615 620 Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala 625 630 635 640 Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Val Pro Ile 645 650 655 Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr 660 665 670 Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro 675 680 685 Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr 690 695 700 Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe Asp Ser Ser Val 705 710 715 720 Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile 725 730 735 Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met 740 745 750 Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly 755 760 765 Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser 770 775 780 Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Val 785 790 795 800 Asn Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn Asn 805 810 815 Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln Pro 820 825 830 Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val Thr 835 840 845 Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met Trp Arg Ile 850 855 860 Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly 865 870 875 880 Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Asn Phe 885 890 895 Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr Val Val Phe Glu 900 905 910 Val Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu 915 920 925 Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 930 935 940 <210> 214 <211> 208 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 214 Met Ala Glu Pro Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile 1 5 10 15 Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg 20 25 30 Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn 35 40 45 Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp 50 55 60 Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser 65 70 75 80 Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu Leu 85 90 95 Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu Lys 100 105 110 Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu Phe 115 120 125 Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro Met 130 135 140 Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly Met 145 150 155 160 Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu Ala 165 170 175 Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe Arg Ser His Arg 180 185 190 Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Gln Asp Met 195 200 205 <210> 215 <211> 503 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 215 Glu Ile Glu Gly Val Leu Pro Ala Leu Gly Val Pro Arg Gly Gln Gly 1 5 10 15 Tyr Val Ala Glu Leu Val Leu Gly Gln Pro Leu Glu Leu Gly Asp Gln 20 25 30 Gln Leu Arg His Gly Glu Val Gly Glu Arg Val Ala Pro Gln Leu Ala 35 40 45 Arg Glu Leu Gln Gly Ala Gln Gln Val Gly Arg Gly Asp Leu Glu Ile 50 55 60 Ala Val Gly Thr Arg Val Leu Arg Ala Arg Val Ala Val His Gly Val 65 70 75 80 Ala Ala Leu Glu His His Gln Gly Arg Val Leu His Ala Arg Gln His 85 90 95 Arg Arg Val Gly Asp Ala Leu His Val Gln Ile Leu Gly Val Gly His 100 105 110 Pro Glu Gly Gly His Leu Ala Gly Leu Pro Pro His Ala Gly His Ala 115 120 125 Ala Gly Leu Val Val Ala Ile Ala Val Gln Gly Asp Gln His His Leu 130 135 140 Gly Leu Leu Gly Ala His Ala Arg Val His Gly Leu His Glu Ser Leu 145 150 155 160 Gln Leu Ala Glu Gly Leu Leu Arg Leu Ala Ala Leu Gly Glu Glu Asp 165 170 175 Pro Ala Gly Leu Ala Arg Glu Leu Val Gly Ser Ala Ala Arg Val Val 180 185 190 His Ala Ala Ala Arg Val Val Val Gly Gln Leu His His Ala Ala Pro 195 200 205 Pro Ala Val Leu Gly Asp Leu Gly Pro Val Gly Val Leu Leu Gln Arg 210 215 220 Ala Leu Pro Val Leu Ala Arg His Ile His Leu Asp Arg Val Leu Leu 225 230 235 240 Leu Asp His His Gly Pro Val Gln Ala Pro Gln Leu Ala Leu Gly Leu 245 250 255 Gly Ala Ala Val Gln Pro Gln Arg Ala Ala Gly Ala Leu Pro Val Leu 260 265 270 Val Gly Asp Leu Gly Val Arg Val His Glu Ala Leu Gln Glu Ala Ala 275 280 285 His His Arg Gly Gln Gly Leu Val Ala Gly Glu Gly Gln Arg Asp Ala 290 295 300 Ala Val Leu Leu Val His Ile Gln Val Ala Asp Ala Ala Val His Leu 305 310 315 320 Ala Leu Leu Gly His Gln Leu Glu Gly Gly Leu Gln Val Ala Leu His 325 330 335 Ala Val Pro Val His Gln Gln Arg His His Phe His Ala Leu Leu Pro 340 345 350 Gly Arg Asn Asp Arg Gln Ala Gln Gly Val Leu His Arg His Leu Ser 355 360 365 Arg Arg Arg Arg Ser Gln Gly Val Val Leu Val Gln Gly Leu Lys His 370 375 380 Ser Leu Ala Val Leu Leu Gly Asp Ala His Gly Gly Glu Gly Glu Ala 385 390 395 400 His Gly Arg Gln Leu Leu Leu Gly Leu Pro Phe Val Leu Ala Val Leu 405 410 415 Ala Asp Val Leu Gln Arg His Met Leu Gly Leu Ala Gly Phe Leu Phe 420 425 430 Gly Arg Gln Arg Arg Arg Arg Arg Arg Arg Ala Gly Arg Ala Arg Val 435 440 445 Leu Ala His His Asp Tyr Phe Phe Phe Leu Ala Val Val Arg Asp His 450 455 460 Ala Ala Val Gly Met Pro Leu Leu Gly Gln Arg Arg Arg Arg Arg Ala 465 470 475 480 Leu Ala Val Arg Arg Ala Ala Gly Arg Ala Pro Ser Ala Phe Gly Gly 485 490 495 Ala Leu Leu Ala Ala Leu Leu 500 <210> 216 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 216 Leu Thr Ser Ser Ala Ala Gly His 1 5 <210> 217 <211> 798 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 217 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ala 1 5 10 15 Ala Asp Glu Asn Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro 20 25 30 Pro Ser Pro Thr Ser Asp Ala Ala Ala Pro Asp Met Gln Glu Met Glu 35 40 45 Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu 50 55 60 Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln Glu 65 70 75 80 Gln Pro Glu Gln Glu Ala Glu Ser Glu Gln Ser Gln Ala Gly Leu Glu 85 90 95 His Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu Ile Lys His Leu 100 105 110 Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Ala Glu 115 120 125 Val Pro Leu Ser Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg Asn Leu 130 135 140 Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys Glu 145 150 155 160 Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu Ala 165 170 175 Leu Ala Thr Tyr His Leu Phe Phe Lys Asn Gln Arg Ile Pro Val Ser 180 185 190 Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Leu Asn Leu Gly Pro 195 200 205 Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro Lys Ile 210 215 220 Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu Gln 225 230 235 240 Gly Ser Gly Glu Glu His Glu His His Ser Ala Leu Val Glu Leu Glu 245 250 255 Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu Thr 260 265 270 His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser Ala 275 280 285 Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu Glu 290 295 300 Glu Met Gln Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val Val Ser 305 310 315 320 Asp Glu Gln Leu Ala Arg Trp Leu Gly Thr Ser Ser Thr Pro Gln Ser 325 330 335 Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr Val 340 345 350 Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu Arg 355 360 365 Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val Arg 370 375 380 Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr 385 390 395 400 Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr 405 410 415 Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr 420 425 430 Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln Gln 435 440 445 Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys 450 455 460 Asn Leu Lys Ala Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser 465 470 475 480 Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg 485 490 495 Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg 500 505 510 Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala 515 520 525 Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro 530 535 540 Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala Tyr 545 550 555 560 His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu Cys 565 570 575 His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys Asn 580 585 590 Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln 595 600 605 Gly Pro Gly Glu Glu Gly Lys Gly Gly Leu Lys Leu Thr Pro Gly Leu 610 615 620 Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr His Pro 625 630 635 640 Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys Ala Glu 645 650 655 Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala Gln Leu Gln 660 665 670 Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly His Gly 675 680 685 Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro Ser Phe Pro 690 695 700 Gln Asp Ala Gln Arg Lys Gln Gln Glu Ala Glu Ser Gly Ala Ala Ala 705 710 715 720 Ala Ala Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly 725 730 735 Gly Gly Asp Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln Pro 740 745 750 Ala Arg Gln Ser Gly Arg Arg Gly Gly Gly Gly Arg Gly Arg Ser Ser 755 760 765 Arg Arg Gln Thr Val Val Leu Gly Gly Glu Ser Lys Gln His Gly Tyr 770 775 780 His Leu Arg Ser Gly Ser Gly Ser Arg Arg Pro Gly Pro Gln 785 790 795 <210> 218 <211> 227 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 218 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr 50 55 60 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 219 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 219 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Ala 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Ile Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Arg Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asn His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 220 <211> 176 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 220 Met Gly Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val Val 1 5 10 15 Leu Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu Lys Ala 20 25 30 Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Thr Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Ala His Met Cys Asp Thr Val Met Trp Met Ser Lys Gln Tyr Asp Met 115 120 125 Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Leu Cys Thr Val Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 221 <211> 200 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 221 Met Ala Ser Val Lys Phe Leu Leu Leu Phe Ala Ser Leu Ile Thr Val 1 5 10 15 Ile Ser Asn Glu Lys Leu Thr Ile Tyr Ile Gly Thr Asn His Thr Leu 20 25 30 Glu Gly Ile Pro Lys Ser Ser Trp Tyr Cys Tyr Phe Asp Gln Asp Pro 35 40 45 Asp Leu Thr Ile Glu Leu Cys Gly Asn Lys Gly Gln Asn Thr Ser Ile 50 55 60 His Leu Ile Asn Phe Lys Cys Gly Asp Asp Leu Lys Leu Ile Asn Ile 65 70 75 80 Thr Lys Glu Tyr Gly Gly Met Tyr Tyr Tyr Val Thr Glu Asn Asn Asn 85 90 95 Met Gln Phe Tyr Glu Val Thr Val Thr Asn Pro Thr Thr Pro Arg Thr 100 105 110 Thr Thr Thr Thr Thr Lys Thr Thr Pro Val Thr Thr Met Gln Leu Thr 115 120 125 Thr Asn Asn Ile Phe Ala Met Arg Gln Lys Ala Asn Asn Ser Thr Ser 130 135 140 Ile Gln Pro Pro Pro Pro Ser Glu Glu Ile Pro Lys Ser Met Ile Gly 145 150 155 160 Ile Ile Val Ala Val Val Val Cys Met Leu Ile Ile Ala Leu Cys Met 165 170 175 Val Tyr Tyr Ala Phe Cys Tyr Arg Lys His Arg Leu Asn Asp Lys Leu 180 185 190 Glu His Leu Leu Ser Val Glu Phe 195 200 <210> 222 <211> 204 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 222 Met Lys Ile Leu Gly Leu Leu Ile Phe Ser Ile Ile Thr Ser Ala Leu 1 5 10 15 Cys Asn Ser Asp Asn Glu Asp Val Thr Val Val Val Gly Ser Asn Tyr 20 25 30 Thr Leu Lys Gly Pro Ala Lys Gly Met Leu Ser Trp Tyr Cys Trp Phe 35 40 45 Gly Thr Asp Thr Glu Gln Thr Glu Leu Cys Asn Leu Gln Asn Gly Lys 50 55 60 Val His Asn Ser Lys Ile Tyr Asn Tyr Ile Cys Asn Gly Thr Asp Leu 65 70 75 80 Ile Leu Leu Asn Ile Thr Lys Ser Tyr Ala Gly Ser Tyr Ser Cys Pro 85 90 95 Gly Asp Asp Ala Asp Asn Met Ile Phe Tyr Lys Leu Gln Val Val Asp 100 105 110 Pro Thr Thr Pro Pro Pro Pro Thr Thr Thr Thr His Thr Thr His Thr 115 120 125 Glu Gln Thr Thr Ala Glu Glu Ala Ala Lys Leu Ala Leu Gln Val Gln 130 135 140 Asp Ser Ser Phe Val Gly Ile Thr Pro Thr Pro Asp Gln Arg Cys Pro 145 150 155 160 Gly Leu Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly Leu Ala Val 165 170 175 Ile Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr 180 185 190 Arg Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 195 200 <210> 223 <211> 143 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 223 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu Val Leu Pro Arg 1 5 10 15 Pro Val Asp Pro Arg Pro Pro Thr Gln Ser Pro Glu Glu Val Arg Lys 20 25 30 Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys 35 40 45 Ser Asp Met His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile 50 55 60 Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Cys Phe Asp Phe 65 70 75 80 Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr 85 90 95 Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Pro Gln Pro Arg 100 105 110 Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg Pro 115 120 125 Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 130 135 140 <210> 224 <211> 445 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 224 Met Ser Lys Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro Val Tyr 1 5 10 15 Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro 20 25 30 Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser 35 40 45 Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu 50 55 60 Lys Leu Gly Asp Gly Val Asp Leu Asp Ser Ser Gly Lys Leu Ile Ser 65 70 75 80 Asn Thr Ala Thr Lys Ala Ala Ala Pro Leu Ser Phe Ser Asn Asn Thr 85 90 95 Ile Ser Leu Asn Met Asp Thr Pro Phe Tyr Asn Asn Asn Gly Lys Leu 100 105 110 Gly Met Lys Val Thr Ala Pro Leu Lys Ile Leu Asp Thr Asp Leu Leu 115 120 125 Lys Thr Leu Val Val Ala Tyr Gly Gln Gly Leu Gly Thr Asn Thr Thr 130 135 140 Gly Ala Leu Val Ala Gln Leu Ala Ser Pro Leu Ala Phe Asp Ser Asn 145 150 155 160 Ser Lys Ile Ala Leu Asn Leu Gly Asn Gly Pro Leu Lys Val Asp Ala 165 170 175 Asn Arg Leu Asn Ile Asn Cys Asn Arg Gly Leu Tyr Val Thr Thr Thr 180 185 190 Lys Asp Ala Leu Glu Ala Asn Ile Ser Trp Ala Asn Ala Met Thr Phe 195 200 205 Ile Gly Asn Ala Met Gly Val Asn Ile Asp Thr Gln Lys Gly Leu Gln 210 215 220 Phe Gly Thr Thr Ser Thr Val Ala Asp Val Lys Asn Ala Tyr Pro Ile 225 230 235 240 Gln Ile Lys Leu Gly Ala Gly Leu Thr Phe Asp Ser Thr Gly Ala Ile 245 250 255 Val Ala Trp Asn Lys Asp Asp Asp Lys Leu Thr Leu Trp Thr Thr Ala 260 265 270 Asp Pro Ser Pro Asn Cys His Ile Tyr Ser Glu Lys Asp Ala Lys Leu 275 280 285 Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Ser 290 295 300 Leu Ile Ala Val Asp Thr Gly Ser Leu Asn Pro Ile Thr Gly Thr Val 305 310 315 320 Thr Thr Ala Leu Val Ser Leu Lys Phe Asp Ala Asn Gly Val Leu Gln 325 330 335 Ser Ser Ser Thr Leu Asp Ser Asp Tyr Trp Asn Phe Arg Gln Gly Asp 340 345 350 Val Thr Pro Ala Glu Ala Tyr Thr Asn Ala Ile Gly Phe Met Pro Asn 355 360 365 Leu Lys Ala Tyr Pro Lys Asn Thr Ser Gly Ala Ala Lys Ser His Ile 370 375 380 Val Gly Lys Val Tyr Leu His Gly Asp Thr Asp Lys Pro Leu Asp Leu 385 390 395 400 Ile Ile Thr Phe Asn Glu Thr Ser Asp Glu Ser Cys Thr Tyr Cys Ile 405 410 415 Asn Phe Gln Trp Gln Trp Gly Ala Asp Gln Tyr Lys Asn Glu Thr Leu 420 425 430 Ala Val Ser Ser Phe Thr Phe Ser Tyr Ile Ala Lys Glu 435 440 445 <210> 225 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 225 Gln Arg Gly Lys Gly Ala Gly Arg Tyr Gly 1 5 10 <210> 226 <211> 62 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 226 Trp Arg Asp Ala Ala Asp Arg Val Arg Asp Arg Val Met Met Gln Leu 1 5 10 15 Leu Ser Asp Ile Phe Val Leu Ala Val Ala Glu Pro Gly Pro Gly Ala 20 25 30 Ala His Arg Ser Pro Ala Ala Val Pro Ala Leu Gly Thr Leu Gly Val 35 40 45 Glu Val Val Lys Gln Pro Leu Ser Gln Thr Val Gln Gln Ile 50 55 60 <210> 227 <211> 47 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 227 Gly Leu Arg Ser Asp Glu Asp Pro Ile Met Pro Asp Gly Ser Asn His 1 5 10 15 Ile Asp His Arg Gly Met Gly Gln Thr Gln Pro Asp Asp Ala Ile Leu 20 25 30 Leu Gly Phe Gly Asp Gly Gly Gly Gly Lys Asn Arg Lys Asn His 35 40 45 <210> 228 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 228 Leu Pro Met Leu Asn Gln 1 5 <210> 229 <211> 75 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 229 Gly Thr Tyr Leu Ser Asp Leu Ser Ile Ser Phe Ile His Ser Cys Leu 1 5 10 15 Thr Pro Arg Arg Val Asp Asn Tyr Asp Thr Gly Gly Leu Thr Ile Trp 20 25 30 Pro Gln Cys Cys Asn Asp Thr Ala Arg Pro Thr Leu Thr Gly Ser Arg 35 40 45 Phe Ile Ser Asn Lys Pro Ala Ser Arg Lys Gly Arg Ala Gln Lys Trp 50 55 60 Ser Cys Asn Phe Ile Arg Leu His Pro Val Tyr 65 70 75 <210> 230 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 230 Leu Leu Pro Gly Ser 1 5 <210> 231 <211> 44 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 231 Phe Ala Gln Arg Cys Cys His Cys Cys Arg His Arg Gly Val Thr Leu 1 5 10 15 Val Val Trp Tyr Gly Phe Ile Gln Leu Arg Phe Pro Thr Ile Lys Ala 20 25 30 Ser Tyr Met Ile Pro His Val Val Gln Lys Ser Gly 35 40 <210> 232 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 232 Leu Leu Arg Ser Ser Asp Arg Cys Gln Lys 1 5 10 <210> 233 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 233 Val Gly Arg Ser Val Ile Thr His Gly Tyr Gly Ser Thr Ala 1 5 10 <210> 234 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 234 Phe Ser Tyr Cys His Ala Ile Arg Lys Met Leu Phe Cys Asp Trp 1 5 10 15 <210> 235 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 235 Val Leu Asn Gln Val Ile Leu Arg Ile Val Tyr Ala Ala Thr Glu Leu 1 5 10 15 Leu Leu Pro Gly Val Asn Thr Gly 20 <210> 236 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 236 Tyr Arg Ala Thr 1 <210> 237 <211> 74 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 237 Gln Asn Phe Lys Ser Ala His His Trp Lys Thr Phe Phe Gly Ala Lys 1 5 10 15 Thr Leu Lys Asp Leu Thr Ala Val Glu Ile Gln Phe Asp Val Thr His 20 25 30 Ser Cys Thr Gln Leu Ile Phe Ser Ile Phe Tyr Phe His Gln Arg Phe 35 40 45 Trp Val Ser Lys Asn Arg Lys Ala Lys Cys Arg Lys Lys Gly Asn Lys 50 55 60 Gly Asp Thr Glu Met Leu Asn Thr His Thr 65 70 <210> 238 <211> 36773 <212> DNA <213> Artificial Sequence <220> <223> p2870 - E1 deleted molecular clone, based on Simian Adenovirus A1320 <220> <221> CDS <222> (23696)..(24250) <223> 22K <220> <221> CDS <222> (25557)..(26177) <223> E3 CR1-alpha <220> <221> CDS <222> (27967)..(28842) <223> E3 CR1-delta <220> <221> CDS <222> (29558)..(29962) <223> E3 14.7K <220> <221> CDS <222> (31937)..(32839) <223> E4 orf6 complement (31937..32839) <400> 238 catcatcaat aatatacctc aaactttttg tgcgcgttaa tatgcaaatg aggcgtttga 60 atttggggat gcggggcggt gattggctgt gggaaaggcg accgttaggg gcggggcggg 120 tgacgttttg atgacgtgtt tgtgaggcgg agccggtttg caagttctcg tgggaaaagt 180 gacgtcaaac gaggtgtggt ttgaacacgg aaatactcaa ttttcccgcg ctctctgaca 240 ggaaatgagg tgtttctggg cggatgcaag tgaaaacggg ccattttcgc gcgaaaactg 300 aatgaggaag tgaaaatctg agtaatttcg cgtttatggc agggaggagt atttgccgag 360 ggccgagtag actttgaccg attacgtggg ggtttcgatt accgtgtttt tcacctaaat 420 ttccgcgtac ggtgtcaaag tccggtgttt ttacatcatt tccccgaaaa gtgccacctg 480 acgtaactat aacggtccta aggtagcgaa agctcagatc tcccgatccc ctatggtgca 540 ctctcagtac aatctgctct gatgccgcat agttaagcca gtatctgctc cctgcttgtg 600 tgttggaggt cgctgagtag tgcgcgagca aaatttaagc tacaacaagg caaggcttga 660 ccgacaattg catgaagaat ctgcttaggg ttaggcgttt tgcgctgctt cgcgatgtac 720 gggccagata tacgcggtac gaaaccgctg atcagcctcg actgtgcctt ctagttgcca 780 gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac 840 tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat 900 tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca 960 tgctggggat gcggtgggct ctatggcttc tgaggcggaa agaaccagca gatctgcaga 1020 tctgaattca tctatgtcgg gtgcggagaa agaggtaatg aaatggcatt atgggtatta 1080 tgggtctgca ttaatgaatc ggccagatta tgctggccac cgtgcatgtg gcctcgcacc 1140 cccgcaagac atggcccgag ttcgagcaca acgtcatgac ccgctgcaat gtgcacctgg 1200 gctcccgccg aggcatgttc atgccatacc agtgcaacat gcaatttgtg aaggtgctgc 1260 tggagcccga tgccatgtcc agagtgagcc tgacgggggt gtttgacatg aatgtggagc 1320 tgtggaaaat tctgagatat gatgaatcca agaccaggtg ccgggcctgc gaatgcggag 1380 gcaagcacgc caggcttcag cccgtgtgtg tggaggtgac ggaggacctg cgacccgatc 1440 atttggtgtt gtcctgcaac gggacggagt tcggctccag cggggaagaa tctgactaga 1500 gtgagtagtg tttgggggtg ggtgggagcc tgcatgatgg gcagaatgac taaaatctgt 1560 gtttttctgc gcagcagcat gagcggaagc gcctcctttg agggaggggt attcagccct 1620 tatctgacgg ggcgtctccc ctcctgggct ggagtgcgtc agaatgtgat gggatccacg 1680 gtggacggcc ggcccgtgca gcccgcgaac tcttcaaccc tgacctacgc gaccctgagc 1740 tcctcgtccg tggacgcagc tgccgccgca gctgctgctt ccgccgccag cgccgtgcgc 1800 ggaatggccc tgggtgccgg ctactacagc tctctggtgg ccaactcgag ttccgccaat 1860 aatcccgcca gcctgaacga ggagaagctg ctgctgctga tggcccagct cgaggccctg 1920 acccagcgcc tgggcgagct gacccagcag gtggctcagc tgcaggcgga gacgcgggcc 1980 gcggttgcca cggtgaaaac caaataaaaa atgaatcaat aaataaacgg aaacggttgt 2040 tgattttaac acagagtctt gaatctttat ttgatttttc gcgcgcggta ggccctggac 2100 caccggtctc gatcattgag cacccggtgg atcttttcca ggacccggta gaggtgggct 2160 tggatgttga ggtacatggg catgagcccg tcccgggggt ggaggtagct ccactgcagg 2220 gcctcgtgct cgggggtggt gttgtaaatc acccagtcat agcaggggcg cagggcgtgg 2280 tgctgcacga tgtccttgag gaggagactg atggccacgg gcagtccctt ggtgtaggtg 2340 ttgacgaacc tgttgagctg ggagggatgc atgcgggggg agatgagatg catcttggcc 2400 tggatcttga gattggcgat gttcccaccc agatcccgcc gggggttcat gttgtgcagg 2460 accaccagca cggtgtatcc ggtgcacttg gggaatttgt catgcaactt ggaagggaag 2520 gcgtgaaaga atttggagac gcccttgtga ccgcccaggt tttccatgca ctcatccatg 2580 atgatggcga tgggcccgtg ggcggcggcc tgggcaaaga cgtttcgggg gtcggacaca 2640 tcgtagttgt ggtcctgggt gagctcgtca taggccattt taatgaattt ggggcggagg 2700 gtgcccgact gggggacaaa ggtgccctcg atcccggggg cgtagttgcc ctcgcagatc 2760 tgcatctccc aggccttgag ctcggagggg gggatcatgt ccacctgcgg ggcgatgaaa 2820 aaaacggttt ccggggcggg ggagatgagc tgggccgaaa gcaggttccg gagcagctgg 2880 gacttgccgc agccggtggg gccgtagatg accccgatga ccggctgcag gtggtagttg 2940 agggagagac agctgccgtc ctcgcggagg aggggggcca cctcgttcat catctcgcgc 3000 acatgcatgt tctcgcgcac gagttccgcc aggaggcgct cgccccccag cgagaggagc 3060 tcttgcagcg aggcgaagtt tttcagcggc ttgagtccgt cggccatggg cattttggag 3120 agggtctgtt gcaagagttc cagacggtcc cagagctcgg tgatgtgctc tagggcatct 3180 cgatccagca gacctcctcg tttcgcgggt tggggcggct gcgggagtag ggcaccaggc 3240 gatgggcgtc cagcgaggcc agggtccggt ccttccaggg tcgcagggtc cgcgtcagcg 3300 tggtctccgt cacggtgaag gggtgcgcgc cgggctgggc gcttgcgagg gtgcgcttca 3360 ggctcatccg gctggtcgag aaccgctccc ggtcggtgcc ctgcgcgtcg gccaggtagc 3420 aattgagcat gagttcgtag ttgagcgcct cggccgcgtg gcccttggcg cggagcttac 3480 ctttggaagt gtgtccgcag acgggacaga ggagggactt gagggcgtag agcttggggg 3540 cgaggaagac ggactcgggg gcgtaggcgt ccgcgccgca gctggcgcag acggtctcgc 3600 actccacgag ccaggtgagg tcggggcggt cggggtcaaa aacgaggttt cctccgtgct 3660 ttttgatgcg tttcttacct ctggtctcca tgagctcgtg tccccgctgg gtgacaaaga 3720 ggctgtccgt gtccccgtag accgacttta tgggccggtc ctcgagcggg gtgccgcggt 3780 cctcgtcgta gaggaacccc gcccactccg agacgaaggc ccgggtccag gccagcacga 3840 aggaggccac gtgggagggg tagcggtcgt tgtccaccag cgggtccacc ttctccaggg 3900 tatgcaagca catgtccccc tcgtccacat ccaggaaggt gattggcttg taagtgtagg 3960 ccacgtgacc gggggtcccg gccggggggg tataaaaggg ggcgggcccc tgctcgtcct 4020 cactgtcttc cggatcgctg tccaggagcg ccagctgttg gggtaggtat tccctctcga 4080 aggcgggcat gacctcggca ctcaggttgt cagtttctag aaacgaggag gatttgatat 4140 tgacggtgcc gttggagacg cctttcatga gcccctcgtc catctggtca gaaaagacga 4200 tctttttgtt gtcgagcttg gtggcgaagg agccgtagag ggcattggag aggagcttgg 4260 cgatggagcg catggtctgg ttcttttcct tgtcggcgcg ctccttggcg gcgatgttga 4320 gctgcacgta ctcgcgcgcc acgcacttcc attcggggaa gacggtggtg agctcgtcgg 4380 gcacgattct gacccgccag ccgcggttgt gcagggtgat gaggtccacg ctggtggcca 4440 cctcgccgcg caggggctcg ttggtccagc agaggcgccc gcccttgcgc gagcagaagg 4500 ggggcagcgg gtccagcatg agctcgtcgg gggggtcggc gtccacggtg aagatgccgg 4560 gcaggagctc ggggtcgaag tagctgatgc aggtgcccag atcgtccagc gccgcttgcc 4620 agtcgcgcac ggccagcgcg cgctcgtagg ggctgagggg cgtgccccag ggcatggggt 4680 gcgtgagcgc ggaggcgtac atgccgcaga tgtcgtagac gtagaggggc tcctcgagga 4740 cgccgatgta ggtggggtag cagcgccccc cgcggatgct ggcgcgcacg tagtcgtaca 4800 gctcgtgcga gggcgcgagg agccccgcgc cgaggttgga gcgctgcggc ttttcggcgc 4860 ggtagacgat ctggcggaag atggcgtggg agttggagga gatggtgggc ctctggaaga 4920 tgttgaagtg ggcgtggggc aggccgaccg agtccctgat gaagtgggcg taggagtcct 4980 gcagcttggc gacgagctcg gcggtgacga ggacgtccag ggcgcagtag tcgagggtct 5040 cttggatgat gtcgtacttg agctggccct tctgcttcca cagctcgcgg ttgagaagga 5100 actcttcgcg gtccttccag tactcttcga gggggaaccc gtcctgatcg gcacggtaag 5160 agcccaccat gtagaactgg ttgacggcct tgtaggcgca gcagcccttc tccacgggga 5220 gggcataagc ttgcgcggcc ttgcgcaggg aggtgtgggt gagggcgaag gtgtcgcgca 5280 ccatgacctt gaggaactgg tgcttgaagt cgaggtcgtc gcagccgccc tgctcccaga 5340 gttggaagtc cgtgcgcttc ttgtaggcgg ggttgggcaa agcgaaagta acatcgttga 5400 agaggatctt gcccgcgcgg ggcatgaagt tgcgagtgat gcggaaaggc tggggcacct 5460 cggcccggtt gttgatgacc tgggcggcga ggacgatctc gtcgaagccg ttgatgttgt 5520 gcccgacgat gtagagttcc acgaatcgcg ggcggccctt gacgtggggc agcttcttga 5580 gctcgtcgta ggtgagctcg gcggggtcgc tgagtccgtg ctgctcaagg gcccagtcgg 5640 cgacgtgggg gttggcgctg aggaaggaag tccagagatc cacggccagg gcggtttgca 5700 agcggtcccg gtactgacgg aactgctggc ccacggccat tttttcgggg gtgatgcagt 5760 agaaggtgcg ggggtcgccg tgccagcggt cccacttgag ctggagggcg aggtcgtggg 5820 cgagctcgac aagcggcggg tccccggaga gtttcatgac cagcatgaag gggacgagct 5880 gcttgccgaa ggaccccatc caggtgtagg tttccacatc gtaggtgagg aagagccttt 5940 cggtgcgagg atgcgagccg atggggaaga actggatctc ctgccaccag ttggaggaat 6000 ggctgttgat gtgatggaag tagaaatgcc gacggcgcgc cgagcactcg tgcttgtgtt 6060 tatacaagcg tccgcagtgc tcgcaacgct gcacgggatg cacgtgctgc acgagctgta 6120 cctgagttcc tttgacgagg aatttcagtg ggcagtggag cgctggcggc tgcatctggt 6180 gctgtactac gtcctggcca tcggcgtggc catcgtctgc ctcgatggtg gtcatgctga 6240 cgagcccgcg cgggaggcag gtccagacct cggctcggac gggtcggaga gcgaggacga 6300 gggcgcgcag gccggagctg tccagggtcc tgagacgctg cggagtcagg tcagtgggca 6360 gcggcggcgc gcggttgact tgcaggagct tttccagggc gcgcgggagg tccagatggt 6420 acttgatctc cacggcgccg ttggtggcga cgtccacggc ttgcagggtc ccgtgcccct 6480 ggggcgccac caccgtgccc cgtttcttct tgggcgctgg cggcgttggc gctggttcca 6540 tgtcggtcag aagcggcggc gaggacgcgc gccgggcggc aggggcggct cggggcccgg 6600 aggcaggggc ggcaggggca cgtcggcgcc gcgcgcgggc aggttctggt actgcgcccg 6660 gagaagactg gcgtgagcga cgacgcgacg gttgacgtcc tggatctgac gcctctgggt 6720 gaaggccacg ggacccgtga gtttgaacct gaaagagagt tcgacagaat caatctcggt 6780 atcgttgacg gcggcctgcc gcaggatctc ttgcacgtcg cccgagttgt cctggtaggc 6840 gatctcggtc atgaactgct cgatctcctc ctcctgaagg tctccgcggc cggcgcgctc 6900 gacggtggcc gcgaggtcgt tggagatgcg ggccatgagc tgcgagaagg cgttcatgcc 6960 ggcctcgttc cagacgcggc tgtagaccac ggctccgtcg gggtcgcgcg cgcgcatgac 7020 cacctgggca aggttgagct cgacgtggcg cgtgaagacc gcgtagttgc agaggcgctg 7080 gtagaggtag ttgagcgtgg tggcgatgtg ctcggtgacg aagaagtaca tgatccagcg 7140 gcggagcggc atctcgctga cgtcgcccag ggcttccaag cgctccatgg cctcgtagaa 7200 gtccacggcg aagttgaaaa actgggagtt gcgcgccgag acggtcaact cctcctccag 7260 aagacggatg agctctgcga tggtggcgcg cacctcgcgc tcgaaggccc cggggggctc 7320 ctcttcttcc atctcctcct cctcttcctc ctccactaac atctcttcta cttcctcctc 7380 aggcggtggt ggcgggggag ggggcctgcg tcgccggcgg cgcacgggca gacggtcgat 7440 gaagcgctcg atggtctcgc cgcgccggcg tcgcatggtc tcggtgacgg cgcgcccgtc 7500 ctcgcggggc cgcagcgtga agacgccgcc gcgcatctcc aggtggccgg gggggtcccc 7560 gttgggcagg gagagggcgc tgacgatgca tcttatcaat tgccccgtag ggactccgcg 7620 caaggacctg agcgtctcga gatccacggg atctgaaaac cgttgaacga aggcttcgag 7680 ccagtcgcag tcgcaaggta ggctgagcac ggtttcttct ggcgggtcat gttggttgga 7740 gggagcgggg cgggcgatgc tgctggtgat gaagttgaaa taggcggttc tgagacggcg 7800 gatggtggcg aggagcacca ggtctttggg cccggcttgc tggatgcgca gacggtcggc 7860 catgccccag gcgtggtcct gacacctggc caggtccttg tagtagtcct gcatgagccg 7920 ctccacgggc acctcctcct cgcccgcgcg gccgtgcatg cgcgtgagcc cgaagccgcg 7980 ctggggctgg acgagcgcca ggtcggcgac gacgcgctcg gcgaggatgg cctgctggac 8040 ctgggtgagg gtggtctgga agtcgtcgaa gtcgacgaag cggtggtagg ctccggtgtt 8100 gatggtgtag gagcagttgg ccatgacgga ccagttgacg gtctggtggc cggggcgcac 8160 gagctcgtgg tacttgaggc gcgagtaggc gcgcgtgtcg aagatgtagt cgttgcaggt 8220 gcgcacgagg tactggtatc cgacgaggaa gtgcggcggc ggctggcggt agagcggcca 8280 tcgctcggtg gcgggggcgc cgggcgcgag gtcctcgagc atgaggcggt ggtagccgta 8340 gatgtacctg gacatccagg tgatgccggc ggcggtggtg gaggcgcgcg ggaactcgcg 8400 gacgcggttc cagatgttgc gcagcggcag gaagtagttc atggtggccg cggtctggcc 8460 cgtgaggcgc gcgcagtcgt ggatgctcta gacatacggg caaaaacgaa agcggtcagc 8520 ggctcgactc cgtggcctgg aggctaagcg aacgggttgg gctgcgcgtg taccccggtt 8580 cgagtctctg ctcgaatcag gctggagccg cagctaacgt ggtactggca ctcccgtctc 8640 gacccaagcc tgctaacgaa acctccagga tacggaggcg ggtcgttttt tggccttggt 8700 cactggtcat gaaaaactag taagcgcgga aagcggccgc ccgcgatggc tcgctgccgt 8760 agtctggaga aagaatcgcc agggttgcgt tgcggtgtgc cccggttcga gactcagcgc 8820 tcggcgccgg ccggattccg cggctaacgt gggcgtggct gccccgtcgt ttccaagacc 8880 ccttagccag ccgacttctc cagttacgga gcgagcccct ctttttcttg tgtttttgcc 8940 agatgcatcc cgtactgcgg cagatgcgcc cccaccctcc accacaaccg cccctaccgc 9000 cgcagcagca gcaacagccg gcgcttctgc ccccgcccca gcagcagcca gccactaccg 9060 cggcggccgc cgtgagcgga gccggcgttc agtatgacct ggccttggaa gagggcgagg 9120 ggctggcgcg gctgggggcg tcgtcgccgg agcggcaccc gcgcgtgcag atgaaaaggg 9180 acgctcgcga ggcctacgtg cccaagcaga acctgttcag agacaggagc ggcgaggagc 9240 ccgaggagat gcgcgcctcc cgcttccacg cggggcggga gctgcggcgc ggcctggacc 9300 gaaagcgggt gctgagggac gaggatttcg aggcggacga gctgacgggg atcagccccg 9360 cgcgcgcgca cgtggccgcg gccaacctgg tcacggcgta cgagcagacc gtgaaggagg 9420 agagcaactt ccaaaaatcc ttcaacaacc acgtgcgcac gctgatcgcg cgcgaggagg 9480 tgaccctggg cctgatgcat ctgtgggacc tgttggaggc catcgtgcag aaccccacga 9540 gcaagccgct gacggcgcag ctgtttctgg tggtgcagca cagtcgggac aacgagacgt 9600 tcagggaggc gctgctgaat atcaccgagc ccgagggccg ctggctcctg gacctggtga 9660 acattctgca gagcatcgtg gtgcaggagc gcgggctgcc gctgtccgag aagctggcgg 9720 ccatcaactt ctcggtgctg agcctgggca agtactacgc taggaagatc tacaagaccc 9780 cgtacgtgcc catagacaag gaggtgaaga tcgacgggtt ttacatgcgc atgaccctga 9840 aagtgctgac cctgagcgac gatctggggg tgtaccgcaa cgacaggatg caccgcgcgg 9900 tgagcgccag ccgccggcgc gagctgagcg accaggagct gatgcacagc ctgcagcggg 9960 ccctgaccgg ggccgggacc gagggggaga gctactttga catgggcgcg gacctgcgct 10020 ggcagcccag ccgccgggct ttagaggcag ccggcggcgt gccctacgtg gaggaggtgg 10080 acgatgatga ggaggagggc gagtacctgg aagactgatg gcgcgaccgt atttttgcta 10140 gatgcagcaa cagccaccgc ctcctgatcc cgcgatgcgg gcggcgctgc agagccagcc 10200 gtccggcatt aactcctcgg acgattggac ccaggccatg caacgcatca tggcgctgac 10260 gacccgcaat cccgaagcct ttagacagca gcctcaggcc aaccggctct cggccatcct 10320 ggaggccgtg gtgccctcgc gctcgaaccc cacgcacgag aaggtgctgg ccatcgtgaa 10380 cgcgctggtg gagaacaagg ccatccgcgg cgacgaggcc gggctggtgt acaacgcgct 10440 gctggagcgc gtggcccgct acaacagcac caacgtgcag acgaacctgg accgcatggt 10500 gaccgacgtg cgcgaggcgg tgtcgcagcg cgagcggttc caccgcgagt cgaacctggg 10560 ctccatggtg gcgctgaacg ccttcctgag cacgcagccc gccaacgtgc cccggggcca 10620 ggaggactac accaacttta tcagcgcgct gcggctgatg gtggccgagg tgccccagag 10680 cgaggtgtac cagtcggggc cggactactt cttccagacc agtcgccagg gcttgcagac 10740 cgtgaacctg agccaggctt tcaagaactt gcagggactg tggggcgtgc aggccccggt 10800 cggggaccgc gcgacggtgt cgagcctgct gacgccgaac tcgcgcctgc tgctgctgct 10860 ggtggcgccc ttcacggaca gcggcagcgt gagccgcgac tcgtacctgg gctacctgct 10920 taacctgtac cgcgaggcca tcgggcaggc gcacgtggac gagcagacct accaggagat 10980 cacccacgtg agccgcgcgc tgggccagga ggacccgggc aacctggagg ccaccctgaa 11040 cttcctgctg accaaccggt cgcagaagat cccgccccag tacgcgctga gcaccgagga 11100 ggagcgcatc ctgcgctacg tgcagcagag cgtggggctg ttcctgatgc aggagggggc 11160 cacgcccagc gccgcgctcg acatgaccgc gcgcaacatg gagcccagca tgtacgcccg 11220 caaccgcccg ttcatcaata agctgatgga ctacttgcat cgggcggccg ccatgaactc 11280 ggactacttt accaacgcca tcttgaaccc gcactggctc ccgccgcccg ggttctacac 11340 gggcgagtac gacatgcccg accccaacga cgggttcctg tgggacgacg tggacagcag 11400 cgtgttctcg ccgcgcccca ccaccaccgt gtggaagaaa gagggcgggg accggcggcc 11460 gtcctcggcg ctgtccggtc gcgcgggtgc tgccgcggcg gtgcccgagg ccgccagccc 11520 cttcccgagc ctgccctttt cgctgaacag cgtgcgcagc agcgagctgg gtcggctgac 11580 gcggccgcgc ctgctgggcg aggaggagta cctgaacgac tccttgttga ggcccgagcg 11640 cgagaaaaac ttccccaata acgggataga gagcctggtg gacaagatga gccgctggaa 11700 gacgtacgcg cacgagcaca gggacgagcc ccgagctagc agcagcgccg gcgccacccg 11760 tagacgccag cggcacgaca ggcagcgggg actggtgtgg gacgatgagg attccgccga 11820 cgacagcagc gtgttggact tgggtgggag tggtggtggt aacccgttcg ctcacttgcg 11880 cccccgtatc gggcgcctga tgtaagaatc tgaaaaaata aaaaaacggt actcaccaag 11940 gccatggcga ccagcgtgcg ttcttctctg ttgtttgtag tagtatgatg aggcgcgtgt 12000 acccggaggg tcctcctccc tcgtacgaga gcgtgatgca gcaggcggtg gcggcggcga 12060 tgcagccccc gctggaggcg ccttacgtgc ccccgcggta cctggcgcct acggaggggc 12120 ggaacagcat tcgttactcg gagctggcac ccttgtacga taccacccgg ttgtacctgg 12180 tggacaacaa gtcggcggac atcgcctcgc tgaactacca gaacgaccac agcaacttcc 12240 tgaccaccgt ggtgcagaac aacgatttca cccccacgga ggccagcacc cagaccatca 12300 actttgacga gcgctcgcgg tggggcggcc agctgaaaac catcatgcac accaacatgc 12360 ccaacgtgaa cgagttcatg tacagcaaca agttcaaggc gcgggtgatg gtctcgcgca 12420 agacccccaa cggggtgacg gtggatgaga attatgatgg tagtcaggac gagctgacct 12480 acgagtgggt ggagtttgag ctgcccgagg gcaacttctc ggtgaccatg accatcgatc 12540 tgatgaacaa cgccatcatc gacaactact tggcggtggg acggcagaac ggggtgctgg 12600 agagcgacat cggcgtgaag ttcgacacgc gcaacttccg gctgggctgg gaccccgtga 12660 ccgagctggt gatgccgggc gtgtacacca acgaggcctt ccaccccgac atcgtcctgc 12720 tgcccggctg cggcgtggac ttcaccgaga gccgcctcag caacctgctg ggcatccgca 12780 agcggcagcc cttccaggag ggcttccaga tcctgtacga ggacctggag gggggcaaca 12840 tccccgcgct gctggacgtc gaagcctacg agaaaagcaa ggaggaggcc gccgcagcgg 12900 cgaccgcggc cgtggctacc gctgcgacca ccgatgcaga tgcagctact actaccaggg 12960 gcgatacatt cgccacccag gcggaggaag cagccgccct agcggcgacc gatgatagtg 13020 aaagtaagat agtcatcaag ccggtggaga aggacagcaa ggacaggagc tacaacgttc 13080 tatcggatgg aaagaacacc gcctaccgca gctggtacct ggcctacaac tacggcgacc 13140 ctgagaaggg cgtgcgctcc tggacgctgc tcaccacctc ggacgtcacc tgcggcgtgg 13200 agcaagtcta ctggtcgctg cccgacatga tgcaagaccc ggtcaccttc cgctccacgc 13260 gtcaagttag caactacccg gtggtgggcg ccgagctcct gcccgtctac tccaagagct 13320 tcttcaacga gcaggccgtc tactcgcagc agctgcgcgc cttcacctcg ctcacgcacg 13380 tcttcaaccg cttccccgag aaccagatcc tcgtccgccc gcccgcgccc accattacca 13440 ccgtcagtga aaacgttcct gctctcacag atcacgggac cctgccgctg cgcagcagta 13500 tccggggagt ccagcgcgtg accgtcactg acgccagacg ccgcacctgc ccctacgtct 13560 acaaggccct gggcgtagtc gcgccgcgcg tcctctcgag ccgcaccttc taaaaaatgt 13620 ccattctcat ctcgcccagt aataacaccg gttggggcct gcgcgcgccc agcaagatgt 13680 acggaggcgc tcgccaacgc tccacgcaac accccgtgcg cgtgcgcggg cacttccgcg 13740 ctccctgggg cgccctcaag ggccgcgtgc gctcgcgcac caccgtcgac gacgtgatcg 13800 accaggtggt ggccgacgcg cgcaactaca cgcccgccgc cgcgcccgcc tccaccgtgg 13860 acgccgtcat cgacagcgtg gtggccgacg cgcgccggta cgcccgcgcc aagagccggc 13920 ggcggcgcat cgcccggcgg caccggagca cccccgccat gcgcgcggcg cgagccttgc 13980 tgcgcagggc caggcgcacg ggacgcaggg ccatgctcag ggcggccaga cgcgcggcct 14040 ccggcagcag cagcgccggc aggacccgca gacgcgcggc cacggcggcg gcggcggcca 14100 tcgccagcat gtcccgcccg cggcgcggca acgtgtactg ggtgcgcgac gccgccaccg 14160 gtgtgcgcgt gcccgtgcgc acccgccccc ctcgcacttg aagatgctga cttcgcgatg 14220 ttgatgtgtc ccagcggcga ggaggatgtc caagcgcaaa ttcaaggaag agatgctcca 14280 ggtcatcgcg cctgagatct acggccccgc ggcggcggtg aaggaggaaa gaaagccccg 14340 caaactgaag cgggtcaaaa aggacaaaaa ggaggaggaa gatgacggac tggtggagtt 14400 tgtgcgcgag ttcgcccccc ggcggcgcgt gcagtggcgc gggcggaaag tgaaaccggt 14460 gctgcggccc ggcaccacgg tggtcttcac gcccggcgag cgttccggct ccgcctccaa 14520 gcgctcctac gacgaggtgt acggggacga ggacatcctc gagcaggcgg ccgagcgtct 14580 gggcgagttt gcttacggca agcgcagccg ccccgcgccc ttgaaagagg aggcggtgtc 14640 catcccgctg gaccacggca accccacgcc gagcctgaag ccggtgaccc tgcagcaggt 14700 gctgccgagc gcggcgccgc gccggggctt caagcgcgag ggcggcgagg atctgtaccc 14760 gaccatgcag ctgatggtgc ccaagcgcca gaagctggag gacgtgctgg agcacatgaa 14820 ggtggacccc gaggtgcagc ccgaggtcaa ggtgcggccc atcaagcagg tggccccggg 14880 cctgggcgtg cagaccgtgg acatcaagat ccccacggag cccatggaaa cgcagaccga 14940 gcccgtgaag cccagcacca gcaccatgga ggtgcagacg gatccctgga tgccggcgcc 15000 ggcttccacc accaccacca cccgccgaag acgcaagtac ggcgcggcca gcctgctgat 15060 gcccaactac gcgctgcatc cttccatcat ccccacgccg ggctaccgcg gcacgcgctt 15120 ctaccgcggc tacagcagcc gccgcaagac caccacccgc cgccgccgtc gccgcacccg 15180 ccgcagcacc accgcgactt ccgccgccgc cttggtgcgg agagtgtacc gcagcgggcg 15240 tgagcctctg accctgccgc gcgcgcgcta ccacccgagc atcgccattt aactctgccg 15300 tcgcctcctt gcagatatgg ccctcacatg ccgcctccgc gtccccatta cgggctaccg 15360 aggaagaaag ccgcgccgta gaaggctgac ggggaacggg ctgcgtcgcc atcaccaccg 15420 gcggcggcgc gccatcagca agcggttggg gggaggcttc ctgcccgcgc tgatccccat 15480 catcgccgcg gcgatcgggg cgatccccgg catagcttcc gtggcggtgc aggcctctca 15540 gcgccactga gacacagctt ggaaaatttg taataaaaaa atggactgac gctcctggtc 15600 ctgtgatgtg tgtttttaga tggaagacat caatttttcg tccctggcac cgcgacacgg 15660 cacgcggccg tttatgggca cctggagcga catcggcaac agccaactga acgggggcgc 15720 cttcaattgg agcagtctct ggagcgggct taagaatttc gggtccacgc tcaaaaccta 15780 tggcagcaag gcgtggaaca gcaccacagg gcaggcgctg agggataagc tgaaagagca 15840 gaacttccag cagaaggtgg tcgatgggct cgcttcgggc atcaacgggg tggtggacct 15900 ggccaaccag gccgtgcagc ggcagatcaa cagccgcctg gacccggtgc cgcccgccgg 15960 ctccgtggag atgccgcagg tggaggagga gctgcctccc ctggacaagc ggggcgagaa 16020 gcgaccccgc cccgacgcgg aggagacgct gctgacgcac acggacgagc cgcccccgta 16080 cgaggaggcg gtgaaactgg gtctgcccac cacgcggccc attgcgcccc tagccaccgg 16140 ggtgctgaaa cccgagagta ataagcccgc gaccctggac ttgcctcctc cccagccttc 16200 ccgcccctcc acagtggcta agcccctgcc gccggtggcc gtggcccgcg cgcgacccgg 16260 gggctccgcc cgccctcatg cgaactggca gagcactctg aacagcatcg tgggtctggg 16320 agtgcagagt gtgaagcgcc gccgctgcta ttaaacctac cgtagcgctt aacttgcttg 16380 tctgtgtgtg tatgtattat gtcgccgccg ctgtccgcca gaaggaggag tgaagaggcg 16440 cgtcgccgag ttgcaagatg gccaccccat cgatgctgcc ccagtgggcg tacatgcaca 16500 tcgccggaca ggacgcttcg gagtacctga gtccgggtct ggtgcagttc gcccgcgcca 16560 cagacaccta cttcagtctg gggaacaagt ttaggaaccc cacggtggcg cccacgcacg 16620 atgtgaccac cgaccgcagc cagcggctga cgctgcgctt cgtgcccgtg gaccgcgagg 16680 acaacaccta ctcgtacaaa gtgcgctaca cgctggccgt gggcgacaac cgcgtgctgg 16740 acatggccag cacctacttt gacatccgcg gcgtgctgga ccggggccct agcttcaaac 16800 cctactccgg caccgcctac aacagcctgg ctcccaaggg agcgcccaat tccagccagt 16860 gggagcgagc taagacaaac aataacggag ccacggaatc tgttaccttt ggtgtggctg 16920 ccatgggggg tatagatatt acaaaagagg gtctccagat tggaactgat gaaactaaag 16980 ctgatagtaa agaaatttat gcagacaaaa cctaccaacc tgaacctcag ataggagagg 17040 agaactggca agaaacattc tcctattatg gcggcagagc tcttaaaaaa gataccaaga 17100 tgaagccatg ctacggctcc tttgctaaac caacgaatgt caaaggaggt caggccaaat 17160 ttaaagttca ggacggtcaa caaactacag aatatgatat cgacttagct ttctttgata 17220 ttccaaactc tggaacagga gggaatggca cgaatgttaa ttatgatcca gatatggtca 17280 tgtacactga aaatgtggat ttggagaccc ctgataccca cattgtttac aaaccaggga 17340 cttccgatga cagttctgaa gcaaacttgc ttcagcagtc catgcctaac agacccaact 17400 atattgggtt tagagacaac tttatcggtc tcatgtacta caacagtact ggcaatatgg 17460 gtgtgctggc tggtcaggcc tcccagctga atgctgtggt cgacttgcaa gacagaaaca 17520 ccgagctatc ctaccagctc ttgcttgact ctctgggcga tagaacccgg tatttcagta 17580 tgtggaacca ggcggtggac agttatgacc ctgatgtgcg cattattgaa aaccatggtg 17640 tggaagatga acttcccaac tattgcttcc cattggatgg agctggtact aatgctgtct 17700 atcagggtgt taaagcaaaa actaatggag gcgcagccaa tggagattgg gagcaagata 17760 cagacgtgtc aaacattaac cagatatgca aggggaacat ctatgccatg gaaatcaacc 17820 tccaagccaa cctgtggaga agtttcctct actcgaacgt ggccctgtac ctgcccgatt 17880 cttacaagta cacgccggcc aacatcacct tgcccacgaa taccaacacc tatgattaca 17940 tgaatgggag agtggcgcct ccctcgttgg tggatgccta catcaacatc ggggcgcgct 18000 ggtcgctgga ccccatggac aacgtcaatc ccttcaacca ccaccgcaac gcggggctgc 18060 gctaccgctc catgcttctg ggcaacgggc gcttcgtgcc cttccacatc caggtgcccc 18120 agaaattttt cgccatcaag agcctcctgc tcctgcccgg gtcctacacc tacgagtgga 18180 acttccgcaa ggacgtcaac atgatcctgc agagctccct cggcaacgac ctgcgcacgg 18240 acggggcctc catctccttc accagcatca acctctacgc caccttcttc cccatggcgc 18300 acaacacggc ctccacgctc gaggccatgc tgcgcaacga caccaacgac cagtccttca 18360 acgactacct ctcggcggcc aacatgctct accccatccc agccaacgcc accaacgtgc 18420 ccatctccat cccctcgcgc aactgggccg ccttccgcgg ctggtccttc acgcgtctca 18480 agaccaagga gacgccctcg ctgggctccg ggttcgaccc ctacttcgtc tactcgggct 18540 ccatccccta cctcgacggc accttctacc tcaaccacac cttcaagaag gtctccatca 18600 ccttcgactc ctccgtcagc tggcccggca acgaccggct cctgacgccc aacgagttcg 18660 aaatcaagcg caccgtcgac ggcgagggct acaacgtggc ccagtgcaac atgaccaagg 18720 actggttcct ggtccagatg ctggcccact acaacatcgg ctaccagggc ttctacgtgc 18780 ccgagggcta caaggaccgc atgtactcct tcttccgcaa cttccagccc atgagccgcc 18840 aggtggtgga cgaggtcaac tacaaggact accaggccgt caccctggcc taccagcaca 18900 acaactcggg cttcgtcggc tacctcgcgc ccaccatgcg ccagggccag ccctaccccg 18960 ccaactaccc gtacccgctc atcggcaaga gcgccgtcac cagcgtcacc cagaaaaagt 19020 tcctctgcga cagggtcatg tggcgcatcc ccttctccag caacttcatg tccatgggcg 19080 cgctcaccga cctcggccag aacatgctct atgccaactc cgcccacgcg ctagacatga 19140 atttcgaagt cgaccccatg gatgagtcca cccttctcta tgttgtcttc gaagtcttcg 19200 acgtcgtccg agtgcaccag ccccaccgcg gcgtcatcga ggccgtctac ctgcgcaccc 19260 ccttctcggc cggtaacgcc accacctaag ctcttgcttc ttgcaagatg gctgagccca 19320 cgggctccgg cgagcaggag ctcagggcca tcatccgcga cctgggctgc gggccctact 19380 tcctgggcac cttcgataag cgcttcccgg gattcatggc cccgcacaag ctggcctgcg 19440 ccatcgtcaa cacggccggc cgcgagaccg ggggcgagca ctggctggcc ttcgcctgga 19500 acccgcgctc gaacacctgc tacctcttcg accccttcgg gttctcggac gagcgcctca 19560 agcagatcta ccagttcgag tacgagggcc tgctgcgccg cagcgccctg gccaccgagg 19620 accgctgcgt caccctggaa aagtccaccc agaccgtgca gggtccgcgc tcggccgcct 19680 gcgggctctt ttgctgcatg ttcctgcacg ccttcgtgca ctggcccgac cgccccatgg 19740 acaagaaccc caccatgaac ttgctgacgg gggtgcccaa cggcatgctc cagtcgcccc 19800 aggtggaacc caccctgcgc cgcaaccagg aggcgctcta ccgcttcctc aacgcccact 19860 ccgcctactt tcgctcccac cgcgcgcgca tcgagaaggc caccgccttc gaccgcatga 19920 atcaagacat gtaaaccgtg tgtgtatgtg aatgctttat tcataataaa cagcacatgt 19980 ttatgccacc ttctctgagg ctctgacttt atttagaaat cgaaggggtt ctgccggctc 20040 tcggcgtgcc ccgcgggcag ggatacgttg cggaactggt acttgggcag ccacttgaac 20100 tcggggatca gcagcttcgg cacggggagg tcggggaacg agtcgctcca cagcttgcgc 20160 gtgagttgca gggcgcccag caggtcgggc gcggagatct tgaaatcgca gttgggaccc 20220 gcgttctgcg cgcgagagtt gcggtacacg gggttgcagc actggaacac catcagggcc 20280 gggtgcttca cgctcgccag caccgtcgcg tcggtgatgc cctccacgtc cagatcctcg 20340 gcgttggcca tcccgaaggg ggtcatcttg caggtctgcc gccccatgct gggcacgcag 20400 ccgggcttgt ggttgcaatc gcagtgcagg gggatcagca tcatctgggc ctgctcggag 20460 ctcatgcccg ggtacatggc cttcatgaaa gcctccagct ggcggaaggc ctgctgcgcc 20520 ttgccgccct cggtgaagaa gaccccgcag gacttgctag agaactggtt ggtagcgcag 20580 cccgcgtcgt gcacgcagca gcgcgcgtcg ttgttggcca gctgcaccac gctgcgcccc 20640 cagcggttct gggtgatctt ggcccggtcg gggttctcct tcagcgcgcg ctgcccgttc 20700 tcgctcgcca catccatctc gatcgtgtgc tccttctgga tcatcacggt cccgtgcagg 20760 caccgcagct tgccctcggc ctcggtgcag ccgtgcagcc acagcgcgca gccggtgctc 20820 tcccagttct tgtgggcgat ctgggagtgc gagtgcacga agccctgcag gaagcggccc 20880 atcatcgcgg tcagggtctt gttgctggtg aaggtcagcg ggatgccgcg gtgctcctcg 20940 ttcacataca ggtggcagat gcggcggtac acctcgccct gctcgggcat cagctggaag 21000 gcggacttca ggtcgctctc cacgcggtac cggtccatca gcagcgtcat cacttccatg 21060 cccttctccc aggccgaaac gatcggcagg ctcagggggt tcttcaccgt catcttagtc 21120 gccgccgccg aagtcagggg gtcgttctcg tccagggtct caaacactcg cttgccgtcc 21180 ttctcggtga tgcgcacggg ggggaaggcg aagcccacgg ccgccagctc ctcctcggcc 21240 tgcctttcgt cctcgctgtc ctggctgatg tcttgcaaag gcacatgctt ggtcttgcgg 21300 ggtttctttt tgggcggcag aggcggcggc ggcggagacg tgctgggcga gcgcgagttc 21360 tcgctcacca cgactatttc ttcttcttgg ccgtcgtccg agaccacgcg gcggtaggca 21420 tgcctcttct ggggcagagg cggaggcgac gggctctcgc ggttcggcgg gcggctggca 21480 gagccccttc cgcgttcggg ggtgcgctcc tggcggcgct gctctgactg acttcctccg 21540 cggccggcca ttgtgttctc ctagggagca acaacaagca tggagactca gccatcgtcg 21600 ccaacatcgc catctgcccc cgccgccgcc gacgagaacc agcagcagca gaatgaaagc 21660 ttaaccgccc cgccgcccag ccccacctcc gacgccgcgg ccccagacat gcaagagatg 21720 gaggaatcca tcgagattga cctgggctac gtgacgcccg cggagcacga ggaggagctg 21780 gcagcgcgct tttcagcccc ggaagagaac caccaagagc agccagagca ggaagcagag 21840 agcgagcaga gccaggctgg gctcgagcat ggcgactacc tgagcggggc agaggacgtg 21900 ctcatcaagc atctggcccg ccaatgcatc atcgtcaagg acgcgctgct cgaccgcgcc 21960 gaggtgcccc tcagcgtggc ggagctcagc cgcgcctacg agcgcaacct cttctcgccg 22020 cgcgtgcccc ccaagcgcca gcccaacggc acctgcgagc ccaacccgcg cctcaacttc 22080 tacccggtct tcgcggtgcc cgaggccctg gccacctacc acctcttttt caagaaccaa 22140 aggatccccg tctcctgccg cgccaaccgc acccgcgccg acgccctgct caacctgggc 22200 cccggcgccc gcctacctga tatcgcctcc ttggaagagg ttcccaagat cttcgagggt 22260 ctgggcagcg acgagactcg ggccgcgaac gctctgcaag gaagcggaga ggagcatgag 22320 caccacagcg ccctggtgga gttggaaggc gacaacgcgc gcctggcggt cctcaagcgc 22380 acggtcgagc tgacccactt cgcctacccg gcgctcaacc tgccccccaa ggtcatgagc 22440 gccgtcatgg accaggtgct catcaagcgc gcctcgcccc tctcggagga ggagatgcag 22500 gaccccgaga gctcggacga gggcaagccc gtggtcagcg acgagcagct ggcgcgctgg 22560 ctgggaacga gtagcacccc ccagagtctg gaagagcggc gcaagctcat gatggccgtg 22620 gtcctggtga ccgtggagct tgagtgtctg cgccgcttct tcgccgacgc ggagaccctg 22680 cgcaaggtcg aggagaacct gcactacctc ttcaggcacg ggttcgtgcg ccaggcctgc 22740 aagatctcca acgtggagct gaccaacctg gtctcctaca tgggcatcct gcacgagaac 22800 cgcctggggc agaacgtgct gcacaccacc ctgcgcgggg aggcccgccg cgactacatc 22860 cgcgactgcg tctacctgta cctctgccac acctggcaga cgggcatggg cgtgtggcag 22920 cagtgcctgg aggagcagaa cctgaaagag ctctgcaagc tcctgcagaa gaacctgaag 22980 gccctgtgga ccgggttcga cgagcgtacc accgcctcgg acctggccga cctcatcttc 23040 cccgagcgcc tgcggctgac gctgcgcaac gggctgcccg actttatgag ccaaagcatg 23100 ttgcaaaact ttcgctcttt catcctcgaa cgctccggga tcctgcccgc cacctgctcc 23160 gcgctgccct cggacttcgt gccgctgacc ttccgcgagt gccccccgcc gctctggagc 23220 cactgctact tgctgcgcct ggccaactac ctggcctacc actcggacgt gatcgaggac 23280 gtcagcggcg agggtctgct cgagtgccac tgccgctgca acctctgcac gccgcaccgc 23340 tccctggcct gcaaccccca gctgctgagc gagacccaga tcatcggcac cttcgagttg 23400 caaggccccg gcgaggaggg caaggggggt ctgaaactca ccccggggct gtggacctcg 23460 gcctacttgc gcaagttcgt gcccgaggac taccatccct tcgagatcag gttctacgag 23520 gaccaatccc agccgcccaa ggccgagctg tcggcctgcg tcatcaccca gggggccatc 23580 ctggcccaat tgcaagccat ccagaaatcc cgccaagaat ttctgctgaa aaagggccac 23640 ggggtctact tggaccccca gaccggagag gagctcaacc ccagcttccc ccagg atg 23698 Met 1 ccc aga gga agc agc aag aag ctg aaa gtg gag ctg ccg ctg ccg ccg 23746 Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Leu Pro Pro 5 10 15 gag gat ttg gag gaa gac tgg gag agc agt cag gca gag gag gag gag 23794 Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu Glu 20 25 30 atg gaa gac tgg gac agc act cag gca gag gag gac agc ctg caa gac 23842 Met Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp 35 40 45 agt ctg gaa gac gag gtg gag gag gca gag gaa gaa gca gcc gcc gcc 23890 Ser Leu Glu Asp Glu Val Glu Glu Ala Glu Glu Glu Ala Ala Ala Ala 50 55 60 65 aga ccg tcg tcc tcg gcg gag aaa gca agc agc acg gat acc atc tcc 23938 Arg Pro Ser Ser Ser Ala Glu Lys Ala Ser Ser Thr Asp Thr Ile Ser 70 75 80 gct ccg ggt cgg ggt ctc ggc ggc cgg gcc cac agt aga tgg gac gag 23986 Ala Pro Gly Arg Gly Leu Gly Gly Arg Ala His Ser Arg Trp Asp Glu 85 90 95 acc ggg cgc ttc ccg aac ccc acc acc cag acc ggt aag aag gag cgg 24034 Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys Glu Arg 100 105 110 cag gga tac aag tcc tgg cgg ggg cac aaa aac gcc atc gtc tcc tgc 24082 Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser Cys 115 120 125 ttg caa gcc tgc ggg ggc aac atc tcc ttc acc cgg cgc tac ctg ctc 24130 Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu Leu 130 135 140 145 ttc cac cgc ggg gtg aac ttc ccc cgc aac atc ttg cat tac tac cgt 24178 Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr Arg 150 155 160 cac ctc cac agc ccc tac tac tgt ttc caa gaa gag gca gaa acc cag 24226 His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu Ala Glu Thr Gln 165 170 175 cag cag cag aaa acc agc agc agc tagaaaatcc acagcggcgg cggcggcagg 24280 Gln Gln Gln Lys Thr Ser Ser Ser 180 185 tggactgagg atcgcggcga acgagccggc gcagacccgg gagctgagga accggatctt 24340 tcccaccctc tatgccatct tccagcagag tcgggggcag gagcaggaac tgaaagtcaa 24400 gaaccgttct ctgcgctcgc tcacccgcag ttgtctgtat cacaagagcg aagaccaact 24460 tcagcgcact ctcgaggacg ccgaggctct cttcaacaag tactgcgcgc tcactcttaa 24520 agagtagccc gcgcccgccc acacacggaa aaaggcggga attacgtcac cacctgcgcc 24580 cttcgcccga ccatcatcat gagcaaagag attcccacgc cttacatgtg gagctaccag 24640 ccccagatgg gcctggccgc cggcgccgcc caggactact ccacccgcat gaactggctc 24700 agtgccgggc ccgcgatgat ctcacgggtg aatgacatcc gcgcccaccg aaaccagata 24760 ctcctagaac agtcagcgat caccgccacg ccccgccatc accttaatcc gcgtaattgg 24820 cccgccgccc tggtgtacca ggaaattccc cagcccacga ccgtactact tccgcgagac 24880 gcccaggccg aagtccagct gactaactca ggtgtccagc tggccggcgg cgccgccctg 24940 tgtcgtcacc gccccgctca gggtataaag cggctggtga tccgaggcag aggcacacag 25000 ctcaacgacg aggtggtgag ctcttcgctg ggtctgcgac ctgacggagt cttccaactc 25060 gccggatcgg ggagatcttc cttcacgcct cgtcaggccg tcctgacttt ggagagttcg 25120 tcctcgcagc cccgctcggg tggcatcggc actctccagt tcgtggagga gttcactccc 25180 tcggtctact tcaacccctt ctccggctcc cccggccact acccggacga gttcatcccg 25240 aacttcgacg ccatcagcga gtcggtggac ggctacgatt gaatgtccca tggtggcgcg 25300 gctgacctag ctcggcttcg acacctggac cactgccgcc gcttccgctg cttcgctcgg 25360 gatctcgccg agtttgccta ctttgagctg cccgaggagc accctcaggg cccggcccac 25420 ggagtgcgga tcatcgtcga agggggcctc gactcccacc tgcttcggat cttcagccag 25480 cgtccgatcc tggtcgagcg cgagcaagga cagacccgtc tgaccctgta ctgcatctgc 25540 aaccaccccg gcctgc atg aaa gtc ttt gtt gtc tgc tgt gta ctg agt ata 25592 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile 190 195 ata aaa gct gag atc agc gac tac tcc gga ctt ccg tgt gtt cct gaa 25640 Ile Lys Ala Glu Ile Ser Asp Tyr Ser Gly Leu Pro Cys Val Pro Glu 200 205 210 tcc atc aac cag tcc ctg ttc ttc acc ggg aac gag acc gag ctc cag 25688 Ser Ile Asn Gln Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln 215 220 225 ctc cag tgt aag ccc cac aag aag tac ctc acc tgg ctg ttc cag ggc 25736 Leu Gln Cys Lys Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly 230 235 240 245 tcc ccg atc gcc gtt gtc aac cac tgc gac aac gac gga gtc ctg ctg 25784 Ser Pro Ile Ala Val Val Asn His Cys Asp Asn Asp Gly Val Leu Leu 250 255 260 agc ggc cct gcc aac ctt act ttt tcc acc cgc aga agc aag ctc cag 25832 Ser Gly Pro Ala Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln 265 270 275 ctc ttc caa ccc ttc ctc ccc ggg acc tat cag tgc gtc tcg gga ccc 25880 Leu Phe Gln Pro Phe Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro 280 285 290 tgc cat cac acc ttc cac ctg atc ccg aat acc aca gcg tcg ctc ccc 25928 Cys His His Thr Phe His Leu Ile Pro Asn Thr Thr Ala Ser Leu Pro 295 300 305 gct act aac aac caa act acc cac caa cgc cac cgt cgc gac ctt tcc 25976 Ala Thr Asn Asn Gln Thr Thr His Gln Arg His Arg Arg Asp Leu Ser 310 315 320 325 tct gaa tct aat acc act acc gga ggt gag ctc cga ggt cga cca acc 26024 Ser Glu Ser Asn Thr Thr Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr 330 335 340 tct ggg att tac tac ggc ccc tgg gag gtg gtg ggg tta ata gcg cta 26072 Ser Gly Ile Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu 345 350 355 ggc cta gtt gtg ggt ggg ctt ttg gct ctc tgc tac cta tac ctc cct 26120 Gly Leu Val Val Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro 360 365 370 tgc tgt tcg tac tta gtg gtg ctg tgt tgc tgg ttt aag aaa tgg ggc 26168 Cys Cys Ser Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly 375 380 385 aga tca ccc tagtgagctg cggtgtgctg gtggcggtgg tgctttcgat 26217 Arg Ser Pro 390 tgtgggactg ggcggcgcgg ctgtagtgaa ggagaaggcc gatccctgct tgcatttcaa 26277 tcccgataaa tgccagctga gttttcagcc cgatggcaat cggtgcgcgg tgctgatcaa 26337 gtgcggatgg gaatgcgaga acgtgagaat cgagtacaat aacaagactc ggaacaatac 26397 tctcgcgtcc acgtggcagc ccggggaccc cgagtggtac accgtctctg tccccggtgc 26457 tgacggctcc ccgcgcaccg tgaataatac tttcattttt gcgcacatgt gcgacacggt 26517 catgtggatg agcaagcagt acgatatgtg gccccccacg aaggagaaca tcgtggtctt 26577 ctccatcgct tacagcctgt gcacggtgct aatcaccgct atcgtgtgcc tgagcattca 26637 catgctcatc gctattcgcc ccagaaataa tgccgaaaaa gaaaaacagc cataacacgt 26697 tttttcacac acctttttca gaccatggcc tctgttaaat ttttgctttt atttgccagt 26757 ctcattactg ttataagtaa tgagaaactc actatttaca ttggcactaa ccacactcta 26817 gaaggaattc caaaatcctc atggtattgc tattttgatc aagatccaga cttaactata 26877 gaactgtgtg gtaacaaggg acaaaataca agcattcatt taattaactt taaatgcgga 26937 gacgatttga aattaattaa tatcactaaa gagtatggag gtatgtatta ctatgttaca 26997 gaaaataaca acatgcagtt ttatgaagtt actgtaacta atcccaccac gcctagaaca 27057 acaacaacca ccacaaagac tacacctgtt accactatgc agctcactac caataacatt 27117 tttgccatgc gtcagaaggc caacaatagc accagcattc aacccccccc acccagtgag 27177 gaaattccca aatccatgat tggcattatt gttgctgtag tggtgtgcat gttgatcatc 27237 gccttgtgca tggtgtacta tgccttctgc tacagaaagc acagactgaa cgacaagcta 27297 gaacacttac taagtgttga attttaattt ttttagaacc atgaagatcc taggcctttt 27357 aattttttct atcattacct ctgctctatg caattctgac aatgaggacg ttactgtcgt 27417 tgtcggatca aattatacac tgaaaggtcc agcgaagggt atgctttcgt ggtattgctg 27477 gtttggaact gacactgaac aaaccgaatt atgcaatctt caaaatggca aagttcataa 27537 ttctaaaatt tacaattata tatgcaatgg cactgatttg atactcctca atatcacgaa 27597 atcatatgct ggcagttatt catgccctgg agatgatgct gacaatatga ttttttataa 27657 attgcaagtg gttgatccca ctactccacc tccacccacc acaactactc acaccacaca 27717 cacagaacaa accacagcag aggaggcggc aaagttagct ttgcaggtcc aagacagttc 27777 atttgttggc attaccccta cacccgatca gcggtgtccg gggctgctcg tcagcggcat 27837 tgtcggtgtg ctttcgggat tagcagttat aatcatctgc atgttcattt ttgcttgctg 27897 ctatagaagg ctttaccgac aaaaatcaga cccactgctg aacctctatg tttaattttt 27957 tccagagcc atg aag gca gtt agc gct cta gtt ttt tgt tct ttg att ggc 28008 Met Lys Ala Val Ser Ala Leu Val Phe Cys Ser Leu Ile Gly 395 400 405 act gtt ttt agt gtt agc ttt tta aaa caa att aat gtt act gag ggg 28056 Thr Val Phe Ser Val Ser Phe Leu Lys Gln Ile Asn Val Thr Glu Gly 410 415 420 gaa aat gtg aca ctg gta ggc gta gaa ggt gct caa aat acc acc tgg 28104 Glu Asn Val Thr Leu Val Gly Val Glu Gly Ala Gln Asn Thr Thr Trp 425 430 435 aca aaa tac cac ctc gat ggg tgg aaa gat att tgc aat tgg agt gtc 28152 Thr Lys Tyr His Leu Asp Gly Trp Lys Asp Ile Cys Asn Trp Ser Val 440 445 450 att act tac aca tgt gag gga gtt aat ttg acc ata gtc aat gcc agc 28200 Ile Thr Tyr Thr Cys Glu Gly Val Asn Leu Thr Ile Val Asn Ala Ser 455 460 465 470 caa aat cag aag ggt tgg att aaa ggg caa tct gtt agt gtt acc agt 28248 Gln Asn Gln Lys Gly Trp Ile Lys Gly Gln Ser Val Ser Val Thr Ser 475 480 485 gag ggg tac tat acc cag cat act ctt atc tat gac att ata gtc ata 28296 Glu Gly Tyr Tyr Thr Gln His Thr Leu Ile Tyr Asp Ile Ile Val Ile 490 495 500 ccg ctg cct acg cct agc cca cct agc act acc aca cag aca acc cac 28344 Pro Leu Pro Thr Pro Ser Pro Pro Ser Thr Thr Thr Gln Thr Thr His 505 510 515 act aca caa aca acc aca tac agt aca tca aat cag cct acc acc act 28392 Thr Thr Gln Thr Thr Thr Tyr Ser Thr Ser Asn Gln Pro Thr Thr Thr 520 525 530 aca aca gca gag gtt gcc agc tcg tct ggg gtc cga gcg gca ttt ttg 28440 Thr Thr Ala Glu Val Ala Ser Ser Ser Gly Val Arg Ala Ala Phe Leu 535 540 545 550 atg ttg gcc cca tct agc agt ccc act gct agt acc aat gag cag act 28488 Met Leu Ala Pro Ser Ser Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr 555 560 565 act gaa ttt ttg tcc act gtc gag agc cac acc aca gct acc tcg agt 28536 Thr Glu Phe Leu Ser Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser 570 575 580 gcc ttc tct agc acc gcc aat ctc tcc tcg ctt tcc tct aca cca atc 28584 Ala Phe Ser Ser Thr Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile 585 590 595 agt ccc gct act act act acc ccc gct att ctt ccc act ccc ctg aag 28632 Ser Pro Ala Thr Thr Thr Thr Pro Ala Ile Leu Pro Thr Pro Leu Lys 600 605 610 caa act gag gac agc ggc atg caa tgg cag atc acc ctg ctc att gtg 28680 Gln Thr Glu Asp Ser Gly Met Gln Trp Gln Ile Thr Leu Leu Ile Val 615 620 625 630 atc ggg ttg gtc atc cta gcc gtg ttg ctc tac tac atc ttc cgc cgc 28728 Ile Gly Leu Val Ile Leu Ala Val Leu Leu Tyr Tyr Ile Phe Arg Arg 635 640 645 cgc att ccc aac gcg cac cgc aag ccg gtc tac aag ccc atc att gtc 28776 Arg Ile Pro Asn Ala His Arg Lys Pro Val Tyr Lys Pro Ile Ile Val 650 655 660 ggg cag ccg gag ccg ctt cag gtg gaa ggg ggt cta agg aat ctt ctc 28824 Gly Gln Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu 665 670 675 ttc tct ttt aca gta tgg tgattgaact atgattccta gacaattctt 28872 Phe Ser Phe Thr Val Trp 680 gatcactatt cttatctgcc tcctccaagt ctgtgccacc ctcgctctgg tggccaacgc 28932 cagtccagac tgtattgggc ccttcgcctc ctacgtgctc tttgccttca tcacctgcat 28992 ctgctgctgt agcatagtct gcctgcttat caccttcttc cagttcattg actggatctt 29052 tgtgcgcatc gcctacctgc gccaccaccc ccagtaccgc gaccagcgag tggcgcagct 29112 gctcaggctc ctctgataag catgcgggct ctgctacttc tcgcgcttct gctgttagtg 29172 ctcccccgtc ccgttgaccc ccggcccccc actcagtccc ccgaggaggt ccgcaaatgc 29232 aaattccaag aaccctggaa attcctcaaa tgctaccgcc aaaaatcaga catgcatccc 29292 agctggatca tgatcattgg gatcgtgaac attctggcct gcaccctcat ctcctttgtg 29352 atttacccct gctttgactt tggttggaac tcgccagagg cgctctatct cccgcctgaa 29412 cctgacacac caccacagca acctcaggca cacgcactac caccaccaca gcctaggcca 29472 caatacatgc ccatattaga ctatgaggcc gagccacagc gacccatgct ccccgctatt 29532 agttacttca atctaaccgg cggag atg act gac cca ctg gcc aac aac aac 29584 Met Thr Asp Pro Leu Ala Asn Asn Asn 685 690 gtc aac gac ctt ctc ctg gac atg gac ggc cgc gcc tcg gag cag cga 29632 Val Asn Asp Leu Leu Leu Asp Met Asp Gly Arg Ala Ser Glu Gln Arg 695 700 705 ctc gcc caa ctt cgc att cgc cag cag cag gag aga gcc gtc aag gag 29680 Leu Ala Gln Leu Arg Ile Arg Gln Gln Gln Glu Arg Ala Val Lys Glu 710 715 720 725 ctg cag gac ggc ata gcc atc cac cag tgc aag aaa ggc atc ttc tgc 29728 Leu Gln Asp Gly Ile Ala Ile His Gln Cys Lys Lys Gly Ile Phe Cys 730 735 740 ctg gtg aaa cag gcc aag atc tcc tac gag gtc acc cag acc gac cat 29776 Leu Val Lys Gln Ala Lys Ile Ser Tyr Glu Val Thr Gln Thr Asp His 745 750 755 cgc ctc tcc tac gag ctc ctg cag cag cgc cag aag ttc acc tgc ctg 29824 Arg Leu Ser Tyr Glu Leu Leu Gln Gln Arg Gln Lys Phe Thr Cys Leu 760 765 770 gtc gga gtc aac ccc atc gtc atc acc cag cag tcg ggc gat acc aag 29872 Val Gly Val Asn Pro Ile Val Ile Thr Gln Gln Ser Gly Asp Thr Lys 775 780 785 ggg tgc atc cac tgc tcc tgc gac tcc ccc gac tgc gtc cac act ctg 29920 Gly Cys Ile His Cys Ser Cys Asp Ser Pro Asp Cys Val His Thr Leu 790 795 800 805 atc aag acc ctc tgc ggc ctc cgc gac ctc ctc ccc atg aac 29962 Ile Lys Thr Leu Cys Gly Leu Arg Asp Leu Leu Pro Met Asn 810 815 taatcacccc cttatccagt gaaataaaga tcatattgat gattaaataa aaaaaataat 30022 catttgattt gaaataaaga tacaatcata ttgatgattt gagtttaata aaaataaaga 30082 atcacttact tgaaatctga taccaggtct ctgtccatgt tttctgccaa caccacttca 30142 ctcccctctt cccagctctg gtactgcagg ccccggcggg ctgcaaactt cctccacacc 30202 ctgaagggga tgtcaaattc ctcctgtccc tcaatcttca ttttatcttc tatcagatgt 30262 ccaaaaagcg cgtccgggtg gatgatgact tcgaccccgt ctacccctac gatgcagaca 30322 acgcaccgac cgtgcccttc atcaaccccc ccttcgtctc ttcagatgga ttccaagaga 30382 agcccctggg ggtgctgtcc ctgcgtctgg ccgatcccgt caccaccaag aacggggaaa 30442 tcaccctcaa gctgggagat ggggtggacc tcgactcctc gggaaaactc atctccaaca 30502 cggccaccaa ggccgccgcc cctctcagtt tttccaacaa caccatttcc cttaacatgg 30562 ataccccttt ttacaacaac aatggaaagt taggcatgaa agtcactgct ccactgaaga 30622 tactagacac agacttgcta aaaacacttg ttgtagctta tggacaaggt ttaggaacaa 30682 acaccactgg tgcccttgtt gcccaactag catccccact tgcttttgat agcaatagca 30742 aaattgccct taatttaggc aatggaccat tgaaagtgga tgcaaataga ctgaacatca 30802 attgcaatag aggactctat gttactacca caaaagatgc actggaagcc aatataagtt 30862 gggctaatgc tatgacattt ataggaaatg ccatgggtgt caatattgat acacaaaaag 30922 gcttgcaatt tggcaccact agtaccgtcg cagatgttaa aaacgcttac cccatacaaa 30982 tcaaacttgg agctggtctc acatttgaca gcacaggtgc aattgttgca tggaacaaag 31042 atgatgacaa gcttacacta tggaccacag ccgacccctc tccaaattgt cacatatatt 31102 ctgaaaagga tgctaagctt acactttgct tgacaaagtg tggcagtcag attctgggca 31162 ctgtttccct catagctgtt gatactggca gtttaaatcc cataacagga acagtaacca 31222 ctgctcttgt ctcacttaaa ttcgatgcaa atggagtttt gcaaagcagc tcaacactag 31282 actcagacta ttggaatttc agacagggag atgttacacc tgctgaagcc tatactaatg 31342 ctataggttt catgcccaat ctaaaagcat accctaaaaa cacaagtgga gctgcaaaaa 31402 gtcacattgt tgggaaagtg tacctacatg gggatacaga caaaccactg gacctcatta 31462 ttactttcaa tgaaacaagt gatgaatctt gcacttactg tattaacttt caatggcagt 31522 ggggggctga tcaatataaa aatgaaacac ttgccgtcag ttcattcacc ttttcctata 31582 ttgctaaaga ataaacccca ctctgtaccc catctctgtc tatggaaaaa actctgaaac 31642 acaaaataaa ataaagttca agtgttttat tgattcaaca gttttacagg attcgagcag 31702 ttatttttcc tccaccctcc caggacatgg aatacaccac cctctccccc cgcacagcct 31762 tgaacatctg aatgccattg gtgatggaca tgcttttggt ctccacgttc cacacagttt 31822 cagagcgagc cagtctcggg tcggtcaggg agatgaaacc ctccgggcac tcccgcatct 31882 gcacctcaca gctcaacagc tgaggattgt cctcggtggt cgggatcacg gtta tct 31939 Ser 820 gga aga agc aga aga gcg gcg gtg gga atc ata gtc cgc gaa cgg gat 31987 Gly Arg Ser Arg Arg Ala Ala Val Gly Ile Ile Val Arg Glu Arg Asp 825 830 835 cgg ccg gtg gtg tcg cat cag gcc ccg cag cag tcg ctg tcg ccg ccg 32035 Arg Pro Val Val Ser His Gln Ala Pro Gln Gln Ser Leu Ser Pro Pro 840 845 850 ctc cgt caa gct gct gct cag ggg gtc cgg gtc cag gga ctc cct cag 32083 Leu Arg Gln Ala Ala Ala Gln Gly Val Arg Val Gln Gly Leu Pro Gln 855 860 865 cat gat gcc cac ggc cct cag cat cag tcg tct ggt gcg gcg ggc gca 32131 His Asp Ala His Gly Pro Gln His Gln Ser Ser Gly Ala Ala Gly Ala 870 875 880 gca gcg cat gcg gat ctc gct cag gtc gct gca gta cgt gca aca cag 32179 Ala Ala His Ala Asp Leu Ala Gln Val Ala Ala Val Arg Ala Thr Gln 885 890 895 900 gac cac cag gtt gtt caa cag tcc ata gtt caa cac gct cca gcc gaa 32227 Asp His Gln Val Val Gln Gln Ser Ile Val Gln His Ala Pro Ala Glu 905 910 915 act cat cgc ggg aag gat gct acc cac gtg gcc gtc gta cca gat cct 32275 Thr His Arg Gly Lys Asp Ala Thr His Val Ala Val Val Pro Asp Pro 920 925 930 cag gta aat caa gtg gcg ccc cct cca gaa cac gct gcc cat gta cat 32323 Gln Val Asn Gln Val Ala Pro Pro Pro Glu His Ala Ala His Val His 935 940 945 gat ctc ctt ggg cat gtg gcg gtt cac cac ctc ccg gta cca cat cac 32371 Asp Leu Leu Gly His Val Ala Val His His Leu Pro Val Pro His His 950 955 960 cct ctg gtt gaa cat gca gcc ccg gat gat cct gcg gaa cca cag ggc 32419 Pro Leu Val Glu His Ala Ala Pro Asp Asp Pro Ala Glu Pro Gln Gly 965 970 975 980 cag cac cgc ccc gcc cgc cat gca gcg aag aga ccc cgg gtc ccg aca 32467 Gln His Arg Pro Ala Arg His Ala Ala Lys Arg Pro Arg Val Pro Thr 985 990 995 atg gca atg gag gac cca ccg ctc gta ccc gtg gat cat ctg gga 32512 Met Ala Met Glu Asp Pro Pro Leu Val Pro Val Asp His Leu Gly 1000 1005 1010 gct gaa caa gtc tat gtt ggc aca gca cag gca tat gct cat gca 32557 Ala Glu Gln Val Tyr Val Gly Thr Ala Gln Ala Tyr Ala His Ala 1015 1020 1025 tct ctt cag cac tct cag ctc ctc ggg ggt caa aac cat atc cca 32602 Ser Leu Gln His Ser Gln Leu Leu Gly Gly Gln Asn His Ile Pro 1030 1035 1040 ggg cac ggg gaa ctc ttg cag gac agc gaa ccc cgc aga aca ggg 32647 Gly His Gly Glu Leu Leu Gln Asp Ser Glu Pro Arg Arg Thr Gly 1045 1050 1055 caa tcc tcg cac ata act tac att gtg cat gga cag ggt atc gca 32692 Gln Ser Ser His Ile Thr Tyr Ile Val His Gly Gln Gly Ile Ala 1060 1065 1070 atc agg cag cac cgg gtg atc ctc cac cag aga agc gcg ggt ctc 32737 Ile Arg Gln His Arg Val Ile Leu His Gln Arg Ser Ala Gly Leu 1075 1080 1085 ggt ctc ctc aca gcg tgg taa ggg ggc cgg ccg ata cgg gtg atg 32782 Gly Leu Leu Thr Ala Trp Gly Gly Arg Pro Ile Arg Val Met 1090 1095 1100 gcg gga cgc ggc tga tcg tgt tcg cga ccg tgt cat gat gca gtt 32827 Ala Gly Arg Gly Ser Cys Ser Arg Pro Cys His Asp Ala Val 1105 1110 gct ttc gga cat tttcgtactt gctgtagcag aacctggtcc gggcgctgca 32879 Ala Phe Gly His 1115 caccgatcgc cggcggcggt cccggcgctt ggaacgctcg gtgttgaagt tgtaaaacag 32939 ccactctctc agaccgtgca gcagatctag ggcctcagga gtgatgaaga tcccatcatg 32999 cctgatggct ctaatcacat cgaccaccgt ggaatgggcc agacccagcc agatgatgca 33059 attttgttgg gtttcggtga cggcggggga gggaagaaca ggaagaacca tgattaactt 33119 ttaatccaaa cggtctcgga gcacttcaaa atgaagatcg cggagatggc acctctcgcc 33179 cccgctgtgt tggtggaaaa taacagccag gtcaaaggtg atacggttct cgagatgttc 33239 cacggtggct tccagcaaag cctccacgcg cacatccaga aacaagacaa tagcgaaagc 33299 gggagggttc tctaattcct caatcatcat gttacactcc tgcaccatcc ccagataatt 33359 ttcatttttc cagccttgaa tgattcgaac tagttcctga ggtaaatcca agccagccat 33419 gataaagagc tcgcgcagag cgccctccac cggcattctt aagcacaccc tcataattcc 33479 aagatattct gctcctggtt cacctgcagc agattgacaa gcggaatatc aaaatctctg 33539 ccgcgatccc taagctcctc cctcagcaat aactgtaagt actctttcat atcctctccg 33599 aaatttttag ccataggacc gccaggaatg agattaggac aagccacatt acagataaac 33659 cgaagtcccc cccagtgagc attgccaaat gtaagattga aataagcatg ctggctagac 33719 ccggtgatat cttccagata actggacaga aaatcgccca ggcaattttt aagaaaatca 33779 acaaaagaaa aatcttccag gtgcacgttt agggcctcgg gaacaacgat ggagtaagtg 33839 caaggggtgc gttccagcat ggttagttag ctgatctgta aaaaaacaaa aaataaaaca 33899 ttaaaccatg ctagcctggc gaacaggtgg gtaaatcgtt ctctccagca ccaggcaggc 33959 cacggggtct ccggcgcgac cctcgtaaaa attgtcgcta tgattgaaaa ccatcacaga 34019 gagacgttcc cggtggccgg cgtgaatgat tcgacaagat gaatacaccc ccggaacatt 34079 ggcgtccgcg agtgaaaaaa agcggccgag gaagcaataa ggcactacaa tgctcagtct 34139 caagtccagc aaagcgatgc catgcggatg aagcacaaaa ttctcaggtg cgtacaaaat 34199 gtaattactc ccctcctgca caggcagcaa agccccagat ccctccagat acacatacaa 34259 agcctcagcg tccatagctt accgagcagc agcacacaac aggcgcaaga gtcagagaaa 34319 ggctgagctc taacctgtcc cccgctctct gctcaatata tagcccagat ctacactgac 34379 gtaaaggcca aagtctaaaa atacccgcca aataatcaca cacgcccagc acacgcccag 34439 aaaccggtga cacactcaaa aaaatacgcg cacttcctca aacgcccaaa ctgccgtcat 34499 ttccgggttc ccacgctacg tcatcagaat tcgactttca aatccgtcga ccgttaaaca 34559 cgtcactcgc cccgccccta acggtcgccc tcctctcggc caatcacagc cccgcatccc 34619 caaattcaaa cgcctcattt gcatattaac gcgcacaaaa agtttgaggt atattattga 34679 tgatgatcgt ttaaactatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc 34739 gcatcaggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc 34799 ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata 34859 acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg 34919 cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct 34979 caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa 35039 gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc 35099 tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt 35159 aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg 35219 ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg 35279 cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct 35339 tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc 35399 tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg 35459 ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc 35519 aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt 35579 aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa 35639 aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat 35699 gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct 35759 gactccccgt cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg 35819 caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag 35879 ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta 35939 attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg 35999 ccattgctgc aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg 36059 gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct 36119 ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta 36179 tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg 36239 gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc 36299 cggcgtcaac acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg 36359 gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga 36419 tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg 36479 ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat 36539 gttgaatact catactcttc ctttttcaat attattgaag catttatcag ggttattgtc 36599 tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca 36659 catttccccg aaaagtgcca cctgacgtct aagaaaccat tattatcatg acattaacct 36719 ataaaaatag gcgtatcacg aggccctttc gtcttcaaga attgtttaaa ctac 36773 <210> 239 <211> 185 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 239 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Leu Pro 1 5 10 15 Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu 20 25 30 Glu Met Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln 35 40 45 Asp Ser Leu Glu Asp Glu Val Glu Glu Ala Glu Glu Glu Ala Ala Ala 50 55 60 Ala Arg Pro Ser Ser Ser Ala Glu Lys Ala Ser Ser Thr Asp Thr Ile 65 70 75 80 Ser Ala Pro Gly Arg Gly Leu Gly Gly Arg Ala His Ser Arg Trp Asp 85 90 95 Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys Glu 100 105 110 Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser 115 120 125 Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu 130 135 140 Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr 145 150 155 160 Arg His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu Ala Glu Thr 165 170 175 Gln Gln Gln Gln Lys Thr Ser Ser Ser 180 185 <210> 240 <211> 207 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 240 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Pro Cys Val Pro Glu Ser Ile Asn Gln 20 25 30 Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys 35 40 45 Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala 50 55 60 Val Val Asn His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala 65 70 75 80 Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro 85 90 95 Phe Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro Cys His His Thr 100 105 110 Phe His Leu Ile Pro Asn Thr Thr Ala Ser Leu Pro Ala Thr Asn Asn 115 120 125 Gln Thr Thr His Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser Asn 130 135 140 Thr Thr Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile Tyr 145 150 155 160 Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val Val 165 170 175 Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser Tyr 180 185 190 Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 195 200 205 <210> 241 <211> 292 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 241 Met Lys Ala Val Ser Ala Leu Val Phe Cys Ser Leu Ile Gly Thr Val 1 5 10 15 Phe Ser Val Ser Phe Leu Lys Gln Ile Asn Val Thr Glu Gly Glu Asn 20 25 30 Val Thr Leu Val Gly Val Glu Gly Ala Gln Asn Thr Thr Trp Thr Lys 35 40 45 Tyr His Leu Asp Gly Trp Lys Asp Ile Cys Asn Trp Ser Val Ile Thr 50 55 60 Tyr Thr Cys Glu Gly Val Asn Leu Thr Ile Val Asn Ala Ser Gln Asn 65 70 75 80 Gln Lys Gly Trp Ile Lys Gly Gln Ser Val Ser Val Thr Ser Glu Gly 85 90 95 Tyr Tyr Thr Gln His Thr Leu Ile Tyr Asp Ile Ile Val Ile Pro Leu 100 105 110 Pro Thr Pro Ser Pro Pro Ser Thr Thr Thr Gln Thr Thr His Thr Thr 115 120 125 Gln Thr Thr Thr Tyr Ser Thr Ser Asn Gln Pro Thr Thr Thr Thr Thr 130 135 140 Ala Glu Val Ala Ser Ser Ser Gly Val Arg Ala Ala Phe Leu Met Leu 145 150 155 160 Ala Pro Ser Ser Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Glu 165 170 175 Phe Leu Ser Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe 180 185 190 Ser Ser Thr Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro 195 200 205 Ala Thr Thr Thr Thr Pro Ala Ile Leu Pro Thr Pro Leu Lys Gln Thr 210 215 220 Glu Asp Ser Gly Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly 225 230 235 240 Leu Val Ile Leu Ala Val Leu Leu Tyr Tyr Ile Phe Arg Arg Arg Ile 245 250 255 Pro Asn Ala His Arg Lys Pro Val Tyr Lys Pro Ile Ile Val Gly Gln 260 265 270 Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser 275 280 285 Phe Thr Val Trp 290 <210> 242 <211> 135 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 242 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu Leu Leu Asp 1 5 10 15 Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg 20 25 30 Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Gly Ile Ala Ile 35 40 45 His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile 50 55 60 Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser Tyr Glu Leu Leu 65 70 75 80 Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val 85 90 95 Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys 100 105 110 Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu 115 120 125 Arg Asp Leu Leu Pro Met Asn 130 135 <210> 243 <211> 273 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 243 Ser Gly Arg Ser Arg Arg Ala Ala Val Gly Ile Ile Val Arg Glu Arg 1 5 10 15 Asp Arg Pro Val Val Ser His Gln Ala Pro Gln Gln Ser Leu Ser Pro 20 25 30 Pro Leu Arg Gln Ala Ala Ala Gln Gly Val Arg Val Gln Gly Leu Pro 35 40 45 Gln His Asp Ala His Gly Pro Gln His Gln Ser Ser Gly Ala Ala Gly 50 55 60 Ala Ala Ala His Ala Asp Leu Ala Gln Val Ala Ala Val Arg Ala Thr 65 70 75 80 Gln Asp His Gln Val Val Gln Gln Ser Ile Val Gln His Ala Pro Ala 85 90 95 Glu Thr His Arg Gly Lys Asp Ala Thr His Val Ala Val Val Pro Asp 100 105 110 Pro Gln Val Asn Gln Val Ala Pro Pro Pro Glu His Ala Ala His Val 115 120 125 His Asp Leu Leu Gly His Val Ala Val His His Leu Pro Val Pro His 130 135 140 His Pro Leu Val Glu His Ala Ala Pro Asp Asp Pro Ala Glu Pro Gln 145 150 155 160 Gly Gln His Arg Pro Ala Arg His Ala Ala Lys Arg Pro Arg Val Pro 165 170 175 Thr Met Ala Met Glu Asp Pro Pro Leu Val Pro Val Asp His Leu Gly 180 185 190 Ala Glu Gln Val Tyr Val Gly Thr Ala Gln Ala Tyr Ala His Ala Ser 195 200 205 Leu Gln His Ser Gln Leu Leu Gly Gly Gln Asn His Ile Pro Gly His 210 215 220 Gly Glu Leu Leu Gln Asp Ser Glu Pro Arg Arg Thr Gly Gln Ser Ser 225 230 235 240 His Ile Thr Tyr Ile Val His Gly Gln Gly Ile Ala Ile Arg Gln His 245 250 255 Arg Val Ile Leu His Gln Arg Ser Ala Gly Leu Gly Leu Leu Thr Ala 260 265 270 Trp <210> 244 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 244 Gly Gly Arg Pro Ile Arg Val Met Ala Gly Arg Gly 1 5 10 <210> 245 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 245 Ser Cys Ser Arg Pro Cys His Asp Ala Val Ala Phe Gly His 1 5 10 <210> 246 <211> 38692 <212> DNA <213> Artificial Sequence <220> <223> p2876 - E1 deleted molecular clone with HIVgagshort insertion, based on Simian Adenovirus A1320 <220> <221> repeat_region <222> (1)..(129) <223> ITR <220> <221> mutation <222> (517)..(517) <223> GATCTG\deleted <220> <221> mutation <222> (539)..(539) <223> C\insertion <220> <221> enhancer <222> (846)..(1106) <223> enhancer <220> <221> misc_feature <222> (1107)..(1334) <223> CMV\promoter <220> <221> primer_bind <222> (1254)..(1275) <223> Primer\Ad\CMV-F <220> <221> TATA_signal <222> (1308)..(1311) <223> TATA <220> <221> CDS <222> (1430)..(2521) <223> HIV gag\short <220> <221> primer_bind <222> (1704)..(1728) <223> Primer HIVgag-5F <220> <221> primer_bind <222> (2423)..(2442) <223> Primer HIVgag-F <220> <221> polyA_signal <222> (2674)..(2876) <223> BGH-PolyA (bovine growth hormone (bGH) polyadenylation signal) <220> <221> misc_feature <222> (3030)..(3415) <223> E1b\del <220> <221> misc_feature <222> (3989)..(5610) <223> IVa2 complement (3989..5610) <220> <221> misc_feature <222> (5599)..(13864) <223> pol complement (5599..13864) <220> <221> misc_feature <222> (8469)..(13864) <223> pTP complement (8469..13864) <220> <221> CDS <222> (12061)..(13821) <223> pIIIa <220> <221> CDS <222> (13904)..(15529) <223> penton <220> <221> CDS <222> (15536)..(16117) <223> pVII <220> <221> CDS <222> (16165)..(17208) <223> V <220> <221> CDS <222> (17236)..(17466) <223> pX <220> <221> CDS <222> (17539)..(18270) <223> pVI <220> <221> CDS <222> (18377)..(21205) <223> hexon <220> <221> CDS <222> (21227)..(21850) <223> protease <220> <221> CDS <222> (21935)..(23470) <223> DBP complement (21935..23470) <220> <221> CDS <222> (25615)..(26169) <223> 22K <220> <221> CDS <222> (26518)..(27198) <223> pVIII <220> <221> CDS <222> (27202)..(27519) <223> E3 12.5K <220> <221> CDS <222> (28081)..(28608) <223> E3 gp19K <220> <221> CDS <222> (28641)..(29240) <223> E3 CR1-beta <220> <221> CDS <222> (29886)..(30761) <223> E3 CR1-delta <220> <221> CDS <222> (31477)..(31881) <223> E3 14.7K <220> <221> CDS <222> (32178)..(33512) <223> fiber <220> <221> misc_feature <222> (33605)..(34938) <223> E4 orf 6/7 complement (33605..33855, 34588..34938) <220> <221> CDS <222> (33856)..(34758) <223> E4\orf6 complement (33856..34758) <220> <221> misc_feature <222> (34588)..(34611) <223> middle\right <220> <221> misc_feature <222> (34919)..(34938) <223> end of E4 orf 6/7 <220> <221> repeat_region <222> (36475)..(36603) <223> ITR complement (36475..36603) <220> <221> misc_feature <222> (36843)..(36849) <223> pMB1\ori low copy number <220> <221> misc_feature <222> (36852)..(37440) <223> pMB1\ori <220> <221> rep_origin <222> (36853)..(36853) <223> ORI <220> <221> CDS <222> (37611)..(38474) <223> AP(R) [note: E-286] complement (37611..38474) <400> 246 catcatcaat aatatacctc aaactttttg tgcgcgttaa tatgcaaatg aggcgtttga 60 atttggggat gcggggcggt gattggctgt gggaaaggcg accgttaggg gcggggcggg 120 tgacgttttg atgacgtgtt tgtgaggcgg agccggtttg caagttctcg tgggaaaagt 180 gacgtcaaac gaggtgtggt ttgaacacgg aaatactcaa ttttcccgcg ctctctgaca 240 ggaaatgagg tgtttctggg cggatgcaag tgaaaacggg ccattttcgc gcgaaaactg 300 aatgaggaag tgaaaatctg agtaatttcg cgtttatggc agggaggagt atttgccgag 360 ggccgagtag actttgaccg attacgtggg ggtttcgatt accgtgtttt tcacctaaat 420 ttccgcgtac ggtgtcaaag tccggtgttt ttacatcatt tccccgaaaa gtgccacctg 480 acgtaactat aacggtccta aggtagcgaa agctcagatc tcccgatccc ctatggtgca 540 ctctcagtac aatctgctct gatgccgcat agttaagcca gtatctgctc cctgcttgtg 600 tgttggaggt cgctgagtag tgcgcgagca aaatttaagc tacaacaagg caaggcttga 660 ccgacaattg catgaagaat ctgcttaggg ttaggcgttt tgcgctgctt cgcgatgtac 720 gggccagata tacgcgttga cattgattat tgactagtta ttaatagtaa tcaattacgg 780 ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc 840 cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca 900 tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg 960 cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg 1020 acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt 1080 ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca 1140 tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg 1200 tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact 1260 ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag 1320 ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata 1380 gaagacaccg ggaccgatcc agcctccgcg ggcgcgcgtc gacagagag atg ggt gcg 1438 Met Gly Ala 1 aga gcg tca gta tta agc ggg gga gaa tta gat cga tgg gaa aaa att 1486 Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp Glu Lys Ile 5 10 15 cgg tta agg cca ggg gga aag aag aag tac aag cta aag cac atc gta 1534 Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys His Ile Val 20 25 30 35 tgg gca agc agg gag cta gaa cga ttc gca gtt aat cct ggc ctg tta 1582 Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro Gly Leu Leu 40 45 50 gaa aca tca gaa ggc tgt aga caa ata ctg gga cag cta caa cca tcc 1630 Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu Gln Pro Ser 55 60 65 ctt cag aca gga tca gag gag ctt cga tca cta tac aac aca gta gca 1678 Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn Thr Val Ala 70 75 80 acc ctc tat tgt gtg cac cag cgg atc gag atc aag gac acc aag gaa 1726 Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp Thr Lys Glu 85 90 95 gct tta gac aag ata gag gaa gag caa aac aag tcc aag aag aag gcc 1774 Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys Lys Lys Ala 100 105 110 115 cag cag gca gca gct gac aca gga cac agc aat cag gtc agc caa aat 1822 Gln Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val Ser Gln Asn 120 125 130 tac cct ata gtg cag aac atc cag ggg caa atg gta cat cag gcc ata 1870 Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His Gln Ala Ile 135 140 145 tca cct aga act tta aat gca tgg gta aaa gta gta gaa gag aag gct 1918 Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu Glu Lys Ala 150 155 160 ttc agc cca gaa gtg ata ccc atg ttt tca gca tta tca gaa gga gcc 1966 Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser Glu Gly Ala 165 170 175 acc cca cag gac ctg aac acg atg ttg aac acc gtg ggg gga cat caa 2014 Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln 180 185 190 195 gca gcc atg caa atg tta aaa gag acc atc aat gag gaa gct gca gaa 2062 Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu Ala Ala Glu 200 205 210 tgg gat aga gtg cat cca gtg cat gca ggg cct att gca cca ggc cag 2110 Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala Pro Gly Gln 215 220 225 atg aga gaa cca agg gga agt gac ata gca gga act act agt acc ctt 2158 Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Thr Leu 230 235 240 cag gaa caa ata gga tgg atg aca aat aat cca cct atc cca gta gga 2206 Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile Pro Val Gly 245 250 255 gag atc tac aag agg tgg ata atc ctg gga ttg aac aag atc gtg agg 2254 Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg 260 265 270 275 atg tat agc cct acc agc att ctg gac ata aga caa gga cca aaa gaa 2302 Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly Pro Lys Glu 280 285 290 ccc ttt aga gac tat gta gac cgg ttc tat aaa act cta aga gct gag 2350 Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu Arg Ala Glu 295 300 305 caa gct tca cag gag gta aaa aat tgg atg aca gaa acc ttg ttg gtc 2398 Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr Leu Leu Val 310 315 320 caa aat gcg aac cca gat tgt aag acc atc ctg aag gct ctc ggc cca 2446 Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala Leu Gly Pro 325 330 335 gcg gct aca cta gaa gaa atg atg aca gca tgt cag gga gta gga gga 2494 Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly 340 345 350 355 ccc ggc cat aag gca aga gtt ttg tag ggatccacta gttctagact 2541 Pro Gly His Lys Ala Arg Val Leu 360 cgaggggggg cccggtacct ttaagaccaa tgacttacaa ggcagctgta gatcttagcc 2601 actttttaaa agaaaagggg ggactggaag ggctaattca ctcccaaaga agacaagata 2661 aaccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc 2721 cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag 2781 gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag 2841 gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct 2901 atggcttctg aggcggaaag aaccagcaga tctgcagatc tgaattcatc tatgtcgggt 2961 gcggagaaag aggtaatgaa atggcattat gggtattatg ggtctgcatt aatgaatcgg 3021 ccagattatg ctggccaccg tgcatgtggc ctcgcacccc cgcaagacat ggcccgagtt 3081 cgagcacaac gtcatgaccc gctgcaatgt gcacctgggc tcccgccgag gcatgttcat 3141 gccataccag tgcaacatgc aatttgtgaa ggtgctgctg gagcccgatg ccatgtccag 3201 agtgagcctg acgggggtgt ttgacatgaa tgtggagctg tggaaaattc tgagatatga 3261 tgaatccaag accaggtgcc gggcctgcga atgcggaggc aagcacgcca ggcttcagcc 3321 cgtgtgtgtg gaggtgacgg aggacctgcg acccgatcat ttggtgttgt cctgcaacgg 3381 gacggagttc ggctccagcg gggaagaatc tgactagagt gagtagtgtt tgggggtggg 3441 tgggagcctg catgatgggc agaatgacta aaatctgtgt ttttctgcgc agcagcatga 3501 gcggaagcgc ctcctttgag ggaggggtat tcagccctta tctgacgggg cgtctcccct 3561 cctgggctgg agtgcgtcag aatgtgatgg gatccacggt ggacggccgg cccgtgcagc 3621 ccgcgaactc ttcaaccctg acctacgcga ccctgagctc ctcgtccgtg gacgcagctg 3681 ccgccgcagc tgctgcttcc gccgccagcg ccgtgcgcgg aatggccctg ggtgccggct 3741 actacagctc tctggtggcc aactcgagtt ccgccaataa tcccgccagc ctgaacgagg 3801 agaagctgct gctgctgatg gcccagctcg aggccctgac ccagcgcctg ggcgagctga 3861 cccagcaggt ggctcagctg caggcggaga cgcgggccgc ggttgccacg gtgaaaacca 3921 aataaaaaat gaatcaataa ataaacggaa acggttgttg attttaacac agagtcttga 3981 atctttattt gatttttcgc gcgcggtagg ccctggacca ccggtctcga tcattgagca 4041 cccggtggat cttttccagg acccggtaga ggtgggcttg gatgttgagg tacatgggca 4101 tgagcccgtc ccgggggtgg aggtagctcc actgcagggc ctcgtgctcg ggggtggtgt 4161 tgtaaatcac ccagtcatag caggggcgca gggcgtggtg ctgcacgatg tccttgagga 4221 ggagactgat ggccacgggc agtcccttgg tgtaggtgtt gacgaacctg ttgagctggg 4281 agggatgcat gcggggggag atgagatgca tcttggcctg gatcttgaga ttggcgatgt 4341 tcccacccag atcccgccgg gggttcatgt tgtgcaggac caccagcacg gtgtatccgg 4401 tgcacttggg gaatttgtca tgcaacttgg aagggaaggc gtgaaagaat ttggagacgc 4461 ccttgtgacc gcccaggttt tccatgcact catccatgat gatggcgatg ggcccgtggg 4521 cggcggcctg ggcaaagacg tttcgggggt cggacacatc gtagttgtgg tcctgggtga 4581 gctcgtcata ggccatttta atgaatttgg ggcggagggt gcccgactgg gggacaaagg 4641 tgccctcgat cccgggggcg tagttgccct cgcagatctg catctcccag gccttgagct 4701 cggagggggg gatcatgtcc acctgcgggg cgatgaaaaa aacggtttcc ggggcggggg 4761 agatgagctg ggccgaaagc aggttccgga gcagctggga cttgccgcag ccggtggggc 4821 cgtagatgac cccgatgacc ggctgcaggt ggtagttgag ggagagacag ctgccgtcct 4881 cgcggaggag gggggccacc tcgttcatca tctcgcgcac atgcatgttc tcgcgcacga 4941 gttccgccag gaggcgctcg ccccccagcg agaggagctc ttgcagcgag gcgaagtttt 5001 tcagcggctt gagtccgtcg gccatgggca ttttggagag ggtctgttgc aagagttcca 5061 gacggtccca gagctcggtg atgtgctcta gggcatctcg atccagcaga cctcctcgtt 5121 tcgcgggttg gggcggctgc gggagtaggg caccaggcga tgggcgtcca gcgaggccag 5181 ggtccggtcc ttccagggtc gcagggtccg cgtcagcgtg gtctccgtca cggtgaaggg 5241 gtgcgcgccg ggctgggcgc ttgcgagggt gcgcttcagg ctcatccggc tggtcgagaa 5301 ccgctcccgg tcggtgccct gcgcgtcggc caggtagcaa ttgagcatga gttcgtagtt 5361 gagcgcctcg gccgcgtggc ccttggcgcg gagcttacct ttggaagtgt gtccgcagac 5421 gggacagagg agggacttga gggcgtagag cttgggggcg aggaagacgg actcgggggc 5481 gtaggcgtcc gcgccgcagc tggcgcagac ggtctcgcac tccacgagcc aggtgaggtc 5541 ggggcggtcg gggtcaaaaa cgaggtttcc tccgtgcttt ttgatgcgtt tcttacctct 5601 ggtctccatg agctcgtgtc cccgctgggt gacaaagagg ctgtccgtgt ccccgtagac 5661 cgactttatg ggccggtcct cgagcggggt gccgcggtcc tcgtcgtaga ggaaccccgc 5721 ccactccgag acgaaggccc gggtccaggc cagcacgaag gaggccacgt gggaggggta 5781 gcggtcgttg tccaccagcg ggtccacctt ctccagggta tgcaagcaca tgtccccctc 5841 gtccacatcc aggaaggtga ttggcttgta agtgtaggcc acgtgaccgg gggtcccggc 5901 cgggggggta taaaaggggg cgggcccctg ctcgtcctca ctgtcttccg gatcgctgtc 5961 caggagcgcc agctgttggg gtaggtattc cctctcgaag gcgggcatga cctcggcact 6021 caggttgtca gtttctagaa acgaggagga tttgatattg acggtgccgt tggagacgcc 6081 tttcatgagc ccctcgtcca tctggtcaga aaagacgatc tttttgttgt cgagcttggt 6141 ggcgaaggag ccgtagaggg cattggagag gagcttggcg atggagcgca tggtctggtt 6201 cttttccttg tcggcgcgct ccttggcggc gatgttgagc tgcacgtact cgcgcgccac 6261 gcacttccat tcggggaaga cggtggtgag ctcgtcgggc acgattctga cccgccagcc 6321 gcggttgtgc agggtgatga ggtccacgct ggtggccacc tcgccgcgca ggggctcgtt 6381 ggtccagcag aggcgcccgc ccttgcgcga gcagaagggg ggcagcgggt ccagcatgag 6441 ctcgtcgggg gggtcggcgt ccacggtgaa gatgccgggc aggagctcgg ggtcgaagta 6501 gctgatgcag gtgcccagat cgtccagcgc cgcttgccag tcgcgcacgg ccagcgcgcg 6561 ctcgtagggg ctgaggggcg tgccccaggg catggggtgc gtgagcgcgg aggcgtacat 6621 gccgcagatg tcgtagacgt agaggggctc ctcgaggacg ccgatgtagg tggggtagca 6681 gcgccccccg cggatgctgg cgcgcacgta gtcgtacagc tcgtgcgagg gcgcgaggag 6741 ccccgcgccg aggttggagc gctgcggctt ttcggcgcgg tagacgatct ggcggaagat 6801 ggcgtgggag ttggaggaga tggtgggcct ctggaagatg ttgaagtggg cgtggggcag 6861 gccgaccgag tccctgatga agtgggcgta ggagtcctgc agcttggcga cgagctcggc 6921 ggtgacgagg acgtccaggg cgcagtagtc gagggtctct tggatgatgt cgtacttgag 6981 ctggcccttc tgcttccaca gctcgcggtt gagaaggaac tcttcgcggt ccttccagta 7041 ctcttcgagg gggaacccgt cctgatcggc acggtaagag cccaccatgt agaactggtt 7101 gacggccttg taggcgcagc agcccttctc cacggggagg gcataagctt gcgcggcctt 7161 gcgcagggag gtgtgggtga gggcgaaggt gtcgcgcacc atgaccttga ggaactggtg 7221 cttgaagtcg aggtcgtcgc agccgccctg ctcccagagt tggaagtccg tgcgcttctt 7281 gtaggcgggg ttgggcaaag cgaaagtaac atcgttgaag aggatcttgc ccgcgcgggg 7341 catgaagttg cgagtgatgc ggaaaggctg gggcacctcg gcccggttgt tgatgacctg 7401 ggcggcgagg acgatctcgt cgaagccgtt gatgttgtgc ccgacgatgt agagttccac 7461 gaatcgcggg cggcccttga cgtggggcag cttcttgagc tcgtcgtagg tgagctcggc 7521 ggggtcgctg agtccgtgct gctcaagggc ccagtcggcg acgtgggggt tggcgctgag 7581 gaaggaagtc cagagatcca cggccagggc ggtttgcaag cggtcccggt actgacggaa 7641 ctgctggccc acggccattt tttcgggggt gatgcagtag aaggtgcggg ggtcgccgtg 7701 ccagcggtcc cacttgagct ggagggcgag gtcgtgggcg agctcgacaa gcggcgggtc 7761 cccggagagt ttcatgacca gcatgaaggg gacgagctgc ttgccgaagg accccatcca 7821 ggtgtaggtt tccacatcgt aggtgaggaa gagcctttcg gtgcgaggat gcgagccgat 7881 ggggaagaac tggatctcct gccaccagtt ggaggaatgg ctgttgatgt gatggaagta 7941 gaaatgccga cggcgcgccg agcactcgtg cttgtgttta tacaagcgtc cgcagtgctc 8001 gcaacgctgc acgggatgca cgtgctgcac gagctgtacc tgagttcctt tgacgaggaa 8061 tttcagtggg cagtggagcg ctggcggctg catctggtgc tgtactacgt cctggccatc 8121 ggcgtggcca tcgtctgcct cgatggtggt catgctgacg agcccgcgcg ggaggcaggt 8181 ccagacctcg gctcggacgg gtcggagagc gaggacgagg gcgcgcaggc cggagctgtc 8241 cagggtcctg agacgctgcg gagtcaggtc agtgggcagc ggcggcgcgc ggttgacttg 8301 caggagcttt tccagggcgc gcgggaggtc cagatggtac ttgatctcca cggcgccgtt 8361 ggtggcgacg tccacggctt gcagggtccc gtgcccctgg ggcgccacca ccgtgccccg 8421 tttcttcttg ggcgctggcg gcgttggcgc tggttccatg tcggtcagaa gcggcggcga 8481 ggacgcgcgc cgggcggcag gggcggctcg gggcccggag gcaggggcgg caggggcacg 8541 tcggcgccgc gcgcgggcag gttctggtac tgcgcccgga gaagactggc gtgagcgacg 8601 acgcgacggt tgacgtcctg gatctgacgc ctctgggtga aggccacggg acccgtgagt 8661 ttgaacctga aagagagttc gacagaatca atctcggtat cgttgacggc ggcctgccgc 8721 aggatctctt gcacgtcgcc cgagttgtcc tggtaggcga tctcggtcat gaactgctcg 8781 atctcctcct cctgaaggtc tccgcggccg gcgcgctcga cggtggccgc gaggtcgttg 8841 gagatgcggg ccatgagctg cgagaaggcg ttcatgccgg cctcgttcca gacgcggctg 8901 tagaccacgg ctccgtcggg gtcgcgcgcg cgcatgacca cctgggcaag gttgagctcg 8961 acgtggcgcg tgaagaccgc gtagttgcag aggcgctggt agaggtagtt gagcgtggtg 9021 gcgatgtgct cggtgacgaa gaagtacatg atccagcggc ggagcggcat ctcgctgacg 9081 tcgcccaggg cttccaagcg ctccatggcc tcgtagaagt ccacggcgaa gttgaaaaac 9141 tgggagttgc gcgccgagac ggtcaactcc tcctccagaa gacggatgag ctctgcgatg 9201 gtggcgcgca cctcgcgctc gaaggccccg gggggctcct cttcttccat ctcctcctcc 9261 tcttcctcct ccactaacat ctcttctact tcctcctcag gcggtggtgg cgggggaggg 9321 ggcctgcgtc gccggcggcg cacgggcaga cggtcgatga agcgctcgat ggtctcgccg 9381 cgccggcgtc gcatggtctc ggtgacggcg cgcccgtcct cgcggggccg cagcgtgaag 9441 acgccgccgc gcatctccag gtggccgggg gggtccccgt tgggcaggga gagggcgctg 9501 acgatgcatc ttatcaattg ccccgtaggg actccgcgca aggacctgag cgtctcgaga 9561 tccacgggat ctgaaaaccg ttgaacgaag gcttcgagcc agtcgcagtc gcaaggtagg 9621 ctgagcacgg tttcttctgg cgggtcatgt tggttggagg gagcggggcg ggcgatgctg 9681 ctggtgatga agttgaaata ggcggttctg agacggcgga tggtggcgag gagcaccagg 9741 tctttgggcc cggcttgctg gatgcgcaga cggtcggcca tgccccaggc gtggtcctga 9801 cacctggcca ggtccttgta gtagtcctgc atgagccgct ccacgggcac ctcctcctcg 9861 cccgcgcggc cgtgcatgcg cgtgagcccg aagccgcgct ggggctggac gagcgccagg 9921 tcggcgacga cgcgctcggc gaggatggcc tgctggacct gggtgagggt ggtctggaag 9981 tcgtcgaagt cgacgaagcg gtggtaggct ccggtgttga tggtgtagga gcagttggcc 10041 atgacggacc agttgacggt ctggtggccg gggcgcacga gctcgtggta cttgaggcgc 10101 gagtaggcgc gcgtgtcgaa gatgtagtcg ttgcaggtgc gcacgaggta ctggtatccg 10161 acgaggaagt gcggcggcgg ctggcggtag agcggccatc gctcggtggc gggggcgccg 10221 ggcgcgaggt cctcgagcat gaggcggtgg tagccgtaga tgtacctgga catccaggtg 10281 atgccggcgg cggtggtgga ggcgcgcggg aactcgcgga cgcggttcca gatgttgcgc 10341 agcggcagga agtagttcat ggtggccgcg gtctggcccg tgaggcgcgc gcagtcgtgg 10401 atgctctaga catacgggca aaaacgaaag cggtcagcgg ctcgactccg tggcctggag 10461 gctaagcgaa cgggttgggc tgcgcgtgta ccccggttcg agtctctgct cgaatcaggc 10521 tggagccgca gctaacgtgg tactggcact cccgtctcga cccaagcctg ctaacgaaac 10581 ctccaggata cggaggcggg tcgttttttg gccttggtca ctggtcatga aaaactagta 10641 agcgcggaaa gcggccgccc gcgatggctc gctgccgtag tctggagaaa gaatcgccag 10701 ggttgcgttg cggtgtgccc cggttcgaga ctcagcgctc ggcgccggcc ggattccgcg 10761 gctaacgtgg gcgtggctgc cccgtcgttt ccaagacccc ttagccagcc gacttctcca 10821 gttacggagc gagcccctct ttttcttgtg tttttgccag atgcatcccg tactgcggca 10881 gatgcgcccc caccctccac cacaaccgcc cctaccgccg cagcagcagc aacagccggc 10941 gcttctgccc ccgccccagc agcagccagc cactaccgcg gcggccgccg tgagcggagc 11001 cggcgttcag tatgacctgg ccttggaaga gggcgagggg ctggcgcggc tgggggcgtc 11061 gtcgccggag cggcacccgc gcgtgcagat gaaaagggac gctcgcgagg cctacgtgcc 11121 caagcagaac ctgttcagag acaggagcgg cgaggagccc gaggagatgc gcgcctcccg 11181 cttccacgcg gggcgggagc tgcggcgcgg cctggaccga aagcgggtgc tgagggacga 11241 ggatttcgag gcggacgagc tgacggggat cagccccgcg cgcgcgcacg tggccgcggc 11301 caacctggtc acggcgtacg agcagaccgt gaaggaggag agcaacttcc aaaaatcctt 11361 caacaaccac gtgcgcacgc tgatcgcgcg cgaggaggtg accctgggcc tgatgcatct 11421 gtgggacctg ttggaggcca tcgtgcagaa ccccacgagc aagccgctga cggcgcagct 11481 gtttctggtg gtgcagcaca gtcgggacaa cgagacgttc agggaggcgc tgctgaatat 11541 caccgagccc gagggccgct ggctcctgga cctggtgaac attctgcaga gcatcgtggt 11601 gcaggagcgc gggctgccgc tgtccgagaa gctggcggcc atcaacttct cggtgctgag 11661 cctgggcaag tactacgcta ggaagatcta caagaccccg tacgtgccca tagacaagga 11721 ggtgaagatc gacgggtttt acatgcgcat gaccctgaaa gtgctgaccc tgagcgacga 11781 tctgggggtg taccgcaacg acaggatgca ccgcgcggtg agcgccagcc gccggcgcga 11841 gctgagcgac caggagctga tgcacagcct gcagcgggcc ctgaccgggg ccgggaccga 11901 gggggagagc tactttgaca tgggcgcgga cctgcgctgg cagcccagcc gccgggcttt 11961 agaggcagcc ggcggcgtgc cctacgtgga ggaggtggac gatgatgagg aggagggcga 12021 gtacctggaa gactgatggc gcgaccgtat ttttgctag atg cag caa cag cca 12075 Met Gln Gln Gln Pro 365 ccg cct cct gat ccc gcg atg cgg gcg gcg ctg cag agc cag ccg tcc 12123 Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu Gln Ser Gln Pro Ser 370 375 380 ggc att aac tcc tcg gac gat tgg acc cag gcc atg caa cgc atc atg 12171 Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala Met Gln Arg Ile Met 385 390 395 400 gcg ctg acg acc cgc aat ccc gaa gcc ttt aga cag cag cct cag gcc 12219 Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg Gln Gln Pro Gln Ala 405 410 415 aac cgg ctc tcg gcc atc ctg gag gcc gtg gtg ccc tcg cgc tcg aac 12267 Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val Pro Ser Arg Ser Asn 420 425 430 ccc acg cac gag aag gtg ctg gcc atc gtg aac gcg ctg gtg gag aac 12315 Pro Thr His Glu Lys Val Leu Ala Ile Val Asn Ala Leu Val Glu Asn 435 440 445 aag gcc atc cgc ggc gac gag gcc ggg ctg gtg tac aac gcg ctg ctg 12363 Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val Tyr Asn Ala Leu Leu 450 455 460 gag cgc gtg gcc cgc tac aac agc acc aac gtg cag acg aac ctg gac 12411 Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val Gln Thr Asn Leu Asp 465 470 475 480 cgc atg gtg acc gac gtg cgc gag gcg gtg tcg cag cgc gag cgg ttc 12459 Arg Met Val Thr Asp Val Arg Glu Ala Val Ser Gln Arg Glu Arg Phe 485 490 495 cac cgc gag tcg aac ctg ggc tcc atg gtg gcg ctg aac gcc ttc ctg 12507 His Arg Glu Ser Asn Leu Gly Ser Met Val Ala Leu Asn Ala Phe Leu 500 505 510 agc acg cag ccc gcc aac gtg ccc cgg ggc cag gag gac tac acc aac 12555 Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln Glu Asp Tyr Thr Asn 515 520 525 ttt atc agc gcg ctg cgg ctg atg gtg gcc gag gtg ccc cag agc gag 12603 Phe Ile Ser Ala Leu Arg Leu Met Val Ala Glu Val Pro Gln Ser Glu 530 535 540 gtg tac cag tcg ggg ccg gac tac ttc ttc cag acc agt cgc cag ggc 12651 Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr Ser Arg Gln Gly 545 550 555 560 ttg cag acc gtg aac ctg agc cag gct ttc aag aac ttg cag gga ctg 12699 Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys Asn Leu Gln Gly Leu 565 570 575 tgg ggc gtg cag gcc ccg gtc ggg gac cgc gcg acg gtg tcg agc ctg 12747 Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala Thr Val Ser Ser Leu 580 585 590 ctg acg ccg aac tcg cgc ctg ctg ctg ctg ctg gtg gcg ccc ttc acg 12795 Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu Val Ala Pro Phe Thr 595 600 605 gac agc ggc agc gtg agc cgc gac tcg tac ctg ggc tac ctg ctt aac 12843 Asp Ser Gly Ser Val Ser Arg Asp Ser Tyr Leu Gly Tyr Leu Leu Asn 610 615 620 ctg tac cgc gag gcc atc ggg cag gcg cac gtg gac gag cag acc tac 12891 Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp Glu Gln Thr Tyr 625 630 635 640 cag gag atc acc cac gtg agc cgc gcg ctg ggc cag gag gac ccg ggc 12939 Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly Gln Glu Asp Pro Gly 645 650 655 aac ctg gag gcc acc ctg aac ttc ctg ctg acc aac cgg tcg cag aag 12987 Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr Asn Arg Ser Gln Lys 660 665 670 atc ccg ccc cag tac gcg ctg agc acc gag gag gag cgc atc ctg cgc 13035 Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu Glu Arg Ile Leu Arg 675 680 685 tac gtg cag cag agc gtg ggg ctg ttc ctg atg cag gag ggg gcc acg 13083 Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met Gln Glu Gly Ala Thr 690 695 700 ccc agc gcc gcg ctc gac atg acc gcg cgc aac atg gag ccc agc atg 13131 Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn Met Glu Pro Ser Met 705 710 715 720 tac gcc cgc aac cgc ccg ttc atc aat aag ctg atg gac tac ttg cat 13179 Tyr Ala Arg Asn Arg Pro Phe Ile Asn Lys Leu Met Asp Tyr Leu His 725 730 735 cgg gcg gcc gcc atg aac tcg gac tac ttt acc aac gcc atc ttg aac 13227 Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr Asn Ala Ile Leu Asn 740 745 750 ccg cac tgg ctc ccg ccg ccc ggg ttc tac acg ggc gag tac gac atg 13275 Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr Gly Glu Tyr Asp Met 755 760 765 ccc gac ccc aac gac ggg ttc ctg tgg gac gac gtg gac agc agc gtg 13323 Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp Val Asp Ser Ser Val 770 775 780 ttc tcg ccg cgc ccc acc acc acc gtg tgg aag aaa gag ggc ggg gac 13371 Phe Ser Pro Arg Pro Thr Thr Thr Val Trp Lys Lys Glu Gly Gly Asp 785 790 795 800 cgg cgg ccg tcc tcg gcg ctg tcc ggt cgc gcg ggt gct gcc gcg gcg 13419 Arg Arg Pro Ser Ser Ala Leu Ser Gly Arg Ala Gly Ala Ala Ala Ala 805 810 815 gtg ccc gag gcc gcc agc ccc ttc ccg agc ctg ccc ttt tcg ctg aac 13467 Val Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu Pro Phe Ser Leu Asn 820 825 830 agc gtg cgc agc agc gag ctg ggt cgg ctg acg cgg ccg cgc ctg ctg 13515 Ser Val Arg Ser Ser Glu Leu Gly Arg Leu Thr Arg Pro Arg Leu Leu 835 840 845 ggc gag gag gag tac ctg aac gac tcc ttg ttg agg ccc gag cgc gag 13563 Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu Arg Pro Glu Arg Glu 850 855 860 aaa aac ttc ccc aat aac ggg ata gag agc ctg gtg gac aag atg agc 13611 Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu Val Asp Lys Met Ser 865 870 875 880 cgc tgg aag acg tac gcg cac gag cac agg gac gag ccc cga gct agc 13659 Arg Trp Lys Thr Tyr Ala His Glu His Arg Asp Glu Pro Arg Ala Ser 885 890 895 agc agc gcc ggc gcc acc cgt aga cgc cag cgg cac gac agg cag cgg 13707 Ser Ser Ala Gly Ala Thr Arg Arg Arg Gln Arg His Asp Arg Gln Arg 900 905 910 gga ctg gtg tgg gac gat gag gat tcc gcc gac gac agc agc gtg ttg 13755 Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp Asp Ser Ser Val Leu 915 920 925 gac ttg ggt ggg agt ggt ggt ggt aac ccg ttc gct cac ttg cgc ccc 13803 Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe Ala His Leu Arg Pro 930 935 940 cgt atc ggg cgc ctg atg taagaatctg aaaaaataaa aaaacggtac 13851 Arg Ile Gly Arg Leu Met 945 950 tcaccaaggc catggcgacc agcgtgcgtt cttctctgtt gtttgtagta gt atg atg 13909 Met Met agg cgc gtg tac ccg gag ggt cct cct ccc tcg tac gag agc gtg atg 13957 Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser Val Met 955 960 965 cag cag gcg gtg gcg gcg gcg atg cag ccc ccg ctg gag gcg cct tac 14005 Gln Gln Ala Val Ala Ala Ala Met Gln Pro Pro Leu Glu Ala Pro Tyr 970 975 980 gtg ccc ccg cgg tac ctg gcg cct acg gag ggg cgg aac agc att cgt 14053 Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg Asn Ser Ile Arg 985 990 995 1000 tac tcg gag ctg gca ccc ttg tac gat acc acc cgg ttg tac ctg 14098 Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg Leu Tyr Leu 1005 1010 1015 gtg gac aac aag tcg gcg gac atc gcc tcg ctg aac tac cag aac 14143 Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr Gln Asn 1020 1025 1030 gac cac agc aac ttc ctg acc acc gtg gtg cag aac aac gat ttc 14188 Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp Phe 1035 1040 1045 acc ccc acg gag gcc agc acc cag acc atc aac ttt gac gag cgc 14233 Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg 1050 1055 1060 tcg cgg tgg ggc ggc cag ctg aaa acc atc atg cac acc aac atg 14278 Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met 1065 1070 1075 ccc aac gtg aac gag ttc atg tac agc aac aag ttc aag gcg cgg 14323 Pro Asn Val Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg 1080 1085 1090 gtg atg gtc tcg cgc aag acc ccc aac ggg gtg acg gtg gat gag 14368 Val Met Val Ser Arg Lys Thr Pro Asn Gly Val Thr Val Asp Glu 1095 1100 1105 aat tat gat ggt agt cag gac gag ctg acc tac gag tgg gtg gag 14413 Asn Tyr Asp Gly Ser Gln Asp Glu Leu Thr Tyr Glu Trp Val Glu 1110 1115 1120 ttt gag ctg ccc gag ggc aac ttc tcg gtg acc atg acc atc gat 14458 Phe Glu Leu Pro Glu Gly Asn Phe Ser Val Thr Met Thr Ile Asp 1125 1130 1135 ctg atg aac aac gcc atc atc gac aac tac ttg gcg gtg gga cgg 14503 Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr Leu Ala Val Gly Arg 1140 1145 1150 cag aac ggg gtg ctg gag agc gac atc ggc gtg aag ttc gac acg 14548 Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val Lys Phe Asp Thr 1155 1160 1165 cgc aac ttc cgg ctg ggc tgg gac ccc gtg acc gag ctg gtg atg 14593 Arg Asn Phe Arg Leu Gly Trp Asp Pro Val Thr Glu Leu Val Met 1170 1175 1180 ccg ggc gtg tac acc aac gag gcc ttc cac ccc gac atc gtc ctg 14638 Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro Asp Ile Val Leu 1185 1190 1195 ctg ccc ggc tgc ggc gtg gac ttc acc gag agc cgc ctc agc aac 14683 Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg Leu Ser Asn 1200 1205 1210 ctg ctg ggc atc cgc aag cgg cag ccc ttc cag gag ggc ttc cag 14728 Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly Phe Gln 1215 1220 1225 atc ctg tac gag gac ctg gag ggg ggc aac atc ccc gcg ctg ctg 14773 Ile Leu Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu 1230 1235 1240 gac gtc gaa gcc tac gag aaa agc aag gag gag gcc gcc gca gcg 14818 Asp Val Glu Ala Tyr Glu Lys Ser Lys Glu Glu Ala Ala Ala Ala 1245 1250 1255 gcg acc gcg gcc gtg gct acc gct gcg acc acc gat gca gat gca 14863 Ala Thr Ala Ala Val Ala Thr Ala Ala Thr Thr Asp Ala Asp Ala 1260 1265 1270 gct act act acc agg ggc gat aca ttc gcc acc cag gcg gag gaa 14908 Ala Thr Thr Thr Arg Gly Asp Thr Phe Ala Thr Gln Ala Glu Glu 1275 1280 1285 gca gcc gcc cta gcg gcg acc gat gat agt gaa agt aag ata gtc 14953 Ala Ala Ala Leu Ala Ala Thr Asp Asp Ser Glu Ser Lys Ile Val 1290 1295 1300 atc aag ccg gtg gag aag gac agc aag gac agg agc tac aac gtt 14998 Ile Lys Pro Val Glu Lys Asp Ser Lys Asp Arg Ser Tyr Asn Val 1305 1310 1315 cta tcg gat gga aag aac acc gcc tac cgc agc tgg tac ctg gcc 15043 Leu Ser Asp Gly Lys Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala 1320 1325 1330 tac aac tac ggc gac cct gag aag ggc gtg cgc tcc tgg acg ctg 15088 Tyr Asn Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu 1335 1340 1345 ctc acc acc tcg gac gtc acc tgc ggc gtg gag caa gtc tac tgg 15133 Leu Thr Thr Ser Asp Val Thr Cys Gly Val Glu Gln Val Tyr Trp 1350 1355 1360 tcg ctg ccc gac atg atg caa gac ccg gtc acc ttc cgc tcc acg 15178 Ser Leu Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr 1365 1370 1375 cgt caa gtt agc aac tac ccg gtg gtg ggc gcc gag ctc ctg ccc 15223 Arg Gln Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Leu Pro 1380 1385 1390 gtc tac tcc aag agc ttc ttc aac gag cag gcc gtc tac tcg cag 15268 Val Tyr Ser Lys Ser Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln 1395 1400 1405 cag ctg cgc gcc ttc acc tcg ctc acg cac gtc ttc aac cgc ttc 15313 Gln Leu Arg Ala Phe Thr Ser Leu Thr His Val Phe Asn Arg Phe 1410 1415 1420 ccc gag aac cag atc ctc gtc cgc ccg ccc gcg ccc acc att acc 15358 Pro Glu Asn Gln Ile Leu Val Arg Pro Pro Ala Pro Thr Ile Thr 1425 1430 1435 acc gtc agt gaa aac gtt cct gct ctc aca gat cac ggg acc ctg 15403 Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr Leu 1440 1445 1450 ccg ctg cgc agc agt atc cgg gga gtc cag cgc gtg acc gtc act 15448 Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val Thr Val Thr 1455 1460 1465 gac gcc aga cgc cgc acc tgc ccc tac gtc tac aag gcc ctg ggc 15493 Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly 1470 1475 1480 gta gtc gcg ccg cgc gtc ctc tcg agc cgc acc ttc taaaaa atg tcc 15541 Val Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe Met Ser 1485 1490 att ctc atc tcg ccc agt aat aac acc ggt tgg ggc ctg cgc gcg 15586 Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg Ala 1495 1500 1505 ccc agc aag atg tac gga ggc gct cgc caa cgc tcc acg caa cac 15631 Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 1510 1515 1520 ccc gtg cgc gtg cgc ggg cac ttc cgc gct ccc tgg ggc gcc ctc 15676 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu 1525 1530 1535 aag ggc cgc gtg cgc tcg cgc acc acc gtc gac gac gtg atc gac 15721 Lys Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp 1540 1545 1550 cag gtg gtg gcc gac gcg cgc aac tac acg ccc gcc gcc gcg ccc 15766 Gln Val Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro 1555 1560 1565 gcc tcc acc gtg gac gcc gtc atc gac agc gtg gtg gcc gac gcg 15811 Ala Ser Thr Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala 1570 1575 1580 cgc cgg tac gcc cgc gcc aag agc cgg cgg cgg cgc atc gcc cgg 15856 Arg Arg Tyr Ala Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg 1585 1590 1595 cgg cac cgg agc acc ccc gcc atg cgc gcg gcg cga gcc ttg ctg 15901 Arg His Arg Ser Thr Pro Ala Met Arg Ala Ala Arg Ala Leu Leu 1600 1605 1610 cgc agg gcc agg cgc acg gga cgc agg gcc atg ctc agg gcg gcc 15946 Arg Arg Ala Arg Arg Thr Gly Arg Arg Ala Met Leu Arg Ala Ala 1615 1620 1625 aga cgc gcg gcc tcc ggc agc agc agc gcc ggc agg acc cgc aga 15991 Arg Arg Ala Ala Ser Gly Ser Ser Ser Ala Gly Arg Thr Arg Arg 1630 1635 1640 cgc gcg gcc acg gcg gcg gcg gcg gcc atc gcc agc atg tcc cgc 16036 Arg Ala Ala Thr Ala Ala Ala Ala Ala Ile Ala Ser Met Ser Arg 1645 1650 1655 ccg cgg cgc ggc aac gtg tac tgg gtg cgc gac gcc gcc acc ggt 16081 Pro Arg Arg Gly Asn Val Tyr Trp Val Arg Asp Ala Ala Thr Gly 1660 1665 1670 gtg cgc gtg ccc gtg cgc acc cgc ccc cct cgc act tgaagatgct 16127 Val Arg Val Pro Val Arg Thr Arg Pro Pro Arg Thr 1675 1680 1685 gacttcgcga tgttgatgtg tcccagcggc gaggagg atg tcc aag cgc aaa ttc 16182 Met Ser Lys Arg Lys Phe 1690 aag gaa gag atg ctc cag gtc atc gcg cct gag atc tac ggc ccc 16227 Lys Glu Glu Met Leu Gln Val Ile Ala Pro Glu Ile Tyr Gly Pro 1695 1700 1705 gcg gcg gcg gtg aag gag gaa aga aag ccc cgc aaa ctg aag cgg 16272 Ala Ala Ala Val Lys Glu Glu Arg Lys Pro Arg Lys Leu Lys Arg 1710 1715 1720 gtc aaa aag gac aaa aag gag gag gaa gat gac gga ctg gtg gag 16317 Val Lys Lys Asp Lys Lys Glu Glu Glu Asp Asp Gly Leu Val Glu 1725 1730 1735 ttt gtg cgc gag ttc gcc ccc cgg cgg cgc gtg cag tgg cgc ggg 16362 Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp Arg Gly 1740 1745 1750 cgg aaa gtg aaa ccg gtg ctg cgg ccc ggc acc acg gtg gtc ttc 16407 Arg Lys Val Lys Pro Val Leu Arg Pro Gly Thr Thr Val Val Phe 1755 1760 1765 acg ccc ggc gag cgt tcc ggc tcc gcc tcc aag cgc tcc tac gac 16452 Thr Pro Gly Glu Arg Ser Gly Ser Ala Ser Lys Arg Ser Tyr Asp 1770 1775 1780 gag gtg tac ggg gac gag gac atc ctc gag cag gcg gcc gag cgt 16497 Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Ala Glu Arg 1785 1790 1795 ctg ggc gag ttt gct tac ggc aag cgc agc cgc ccc gcg ccc ttg 16542 Leu Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Pro Ala Pro Leu 1800 1805 1810 aaa gag gag gcg gtg tcc atc ccg ctg gac cac ggc aac ccc acg 16587 Lys Glu Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr 1815 1820 1825 ccg agc ctg aag ccg gtg acc ctg cag cag gtg ctg ccg agc gcg 16632 Pro Ser Leu Lys Pro Val Thr Leu Gln Gln Val Leu Pro Ser Ala 1830 1835 1840 gcg ccg cgc cgg ggc ttc aag cgc gag ggc ggc gag gat ctg tac 16677 Ala Pro Arg Arg Gly Phe Lys Arg Glu Gly Gly Glu Asp Leu Tyr 1845 1850 1855 ccg acc atg cag ctg atg gtg ccc aag cgc cag aag ctg gag gac 16722 Pro Thr Met Gln Leu Met Val Pro Lys Arg Gln Lys Leu Glu Asp 1860 1865 1870 gtg ctg gag cac atg aag gtg gac ccc gag gtg cag ccc gag gtc 16767 Val Leu Glu His Met Lys Val Asp Pro Glu Val Gln Pro Glu Val 1875 1880 1885 aag gtg cgg ccc atc aag cag gtg gcc ccg ggc ctg ggc gtg cag 16812 Lys Val Arg Pro Ile Lys Gln Val Ala Pro Gly Leu Gly Val Gln 1890 1895 1900 acc gtg gac atc aag atc ccc acg gag ccc atg gaa acg cag acc 16857 Thr Val Asp Ile Lys Ile Pro Thr Glu Pro Met Glu Thr Gln Thr 1905 1910 1915 gag ccc gtg aag ccc agc acc agc acc atg gag gtg cag acg gat 16902 Glu Pro Val Lys Pro Ser Thr Ser Thr Met Glu Val Gln Thr Asp 1920 1925 1930 ccc tgg atg ccg gcg ccg gct tcc acc acc acc acc acc cgc cga 16947 Pro Trp Met Pro Ala Pro Ala Ser Thr Thr Thr Thr Thr Arg Arg 1935 1940 1945 aga cgc aag tac ggc gcg gcc agc ctg ctg atg ccc aac tac gcg 16992 Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn Tyr Ala 1950 1955 1960 ctg cat cct tcc atc atc ccc acg ccg ggc tac cgc ggc acg cgc 17037 Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg 1965 1970 1975 ttc tac cgc ggc tac agc agc cgc cgc aag acc acc acc cgc cgc 17082 Phe Tyr Arg Gly Tyr Ser Ser Arg Arg Lys Thr Thr Thr Arg Arg 1980 1985 1990 cgc cgt cgc cgc acc cgc cgc agc acc acc gcg act tcc gcc gcc 17127 Arg Arg Arg Arg Thr Arg Arg Ser Thr Thr Ala Thr Ser Ala Ala 1995 2000 2005 gcc ttg gtg cgg aga gtg tac cgc agc ggg cgt gag cct ctg acc 17172 Ala Leu Val Arg Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu Thr 2010 2015 2020 ctg ccg cgc gcg cgc tac cac ccg agc atc gcc att taactctgcc 17218 Leu Pro Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 2025 2030 gtcgcctcct tgcagat atg gcc ctc aca tgc cgc ctc cgc gtc ccc att 17268 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile 2035 2040 2045 acg ggc tac cga gga aga aag ccg cgc cgt aga agg ctg acg ggg 17313 Thr Gly Tyr Arg Gly Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly 2050 2055 2060 aac ggg ctg cgt cgc cat cac cac cgg cgg cgg cgc gcc atc agc 17358 Asn Gly Leu Arg Arg His His His Arg Arg Arg Arg Ala Ile Ser 2065 2070 2075 aag cgg ttg ggg gga ggc ttc ctg ccc gcg ctg atc ccc atc atc 17403 Lys Arg Leu Gly Gly Gly Phe Leu Pro Ala Leu Ile Pro Ile Ile 2080 2085 2090 gcc gcg gcg atc ggg gcg atc ccc ggc ata gct tcc gtg gcg gtg 17448 Ala Ala Ala Ile Gly Ala Ile Pro Gly Ile Ala Ser Val Ala Val 2095 2100 2105 cag gcc tct cag cgc cac tgagacacag cttggaaaat ttgtaataaa 17496 Gln Ala Ser Gln Arg His 2110 aaaatggact gacgctcctg gtcctgtgat gtgtgttttt ag atg gaa gac atc 17550 Met Glu Asp Ile 2115 aat ttt tcg tcc ctg gca ccg cga cac ggc acg cgg ccg ttt atg 17595 Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg Pro Phe Met 2120 2125 2130 ggc acc tgg agc gac atc ggc aac agc caa ctg aac ggg ggc gcc 17640 Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly Gly Ala 2135 2140 2145 ttc aat tgg agc agt ctc tgg agc ggg ctt aag aat ttc ggg tcc 17685 Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser 2150 2155 2160 acg ctc aaa acc tat ggc agc aag gcg tgg aac agc acc aca ggg 17730 Thr Leu Lys Thr Tyr Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly 2165 2170 2175 cag gcg ctg agg gat aag ctg aaa gag cag aac ttc cag cag aag 17775 Gln Ala Leu Arg Asp Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys 2180 2185 2190 gtg gtc gat ggg ctc gct tcg ggc atc aac ggg gtg gtg gac ctg 17820 Val Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu 2195 2200 2205 gcc aac cag gcc gtg cag cgg cag atc aac agc cgc ctg gac ccg 17865 Ala Asn Gln Ala Val Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro 2210 2215 2220 gtg ccg ccc gcc ggc tcc gtg gag atg ccg cag gtg gag gag gag 17910 Val Pro Pro Ala Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu 2225 2230 2235 ctg cct ccc ctg gac aag cgg ggc gag aag cga ccc cgc ccc gac 17955 Leu Pro Pro Leu Asp Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp 2240 2245 2250 gcg gag gag acg ctg ctg acg cac acg gac gag ccg ccc ccg tac 18000 Ala Glu Glu Thr Leu Leu Thr His Thr Asp Glu Pro Pro Pro Tyr 2255 2260 2265 gag gag gcg gtg aaa ctg ggt ctg ccc acc acg cgg ccc att gcg 18045 Glu Glu Ala Val Lys Leu Gly Leu Pro Thr Thr Arg Pro Ile Ala 2270 2275 2280 ccc cta gcc acc ggg gtg ctg aaa ccc gag agt aat aag ccc gcg 18090 Pro Leu Ala Thr Gly Val Leu Lys Pro Glu Ser Asn Lys Pro Ala 2285 2290 2295 acc ctg gac ttg cct cct ccc cag cct tcc cgc ccc tcc aca gtg 18135 Thr Leu Asp Leu Pro Pro Pro Gln Pro Ser Arg Pro Ser Thr Val 2300 2305 2310 gct aag ccc ctg ccg ccg gtg gcc gtg gcc cgc gcg cga ccc ggg 18180 Ala Lys Pro Leu Pro Pro Val Ala Val Ala Arg Ala Arg Pro Gly 2315 2320 2325 ggc tcc gcc cgc cct cat gcg aac tgg cag agc act ctg aac agc 18225 Gly Ser Ala Arg Pro His Ala Asn Trp Gln Ser Thr Leu Asn Ser 2330 2335 2340 atc gtg ggt ctg gga gtg cag agt gtg aag cgc cgc cgc tgc tat 18270 Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg Arg Arg Cys Tyr 2345 2350 2355 taaacctacc gtagcgctta acttgcttgt ctgtgtgtgt atgtattatg tcgccgccgc 18330 tgtccgccag aaggaggagt gaagaggcgc gtcgccgagt tgcaag atg gcc acc 18385 Met Ala Thr cca tcg atg ctg ccc cag tgg gcg tac atg cac atc gcc gga cag 18430 Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala Gly Gln 2360 2365 2370 gac gct tcg gag tac ctg agt ccg ggt ctg gtg cag ttc gcc cgc 18475 Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala Arg 2375 2380 2385 gcc aca gac acc tac ttc agt ctg ggg aac aag ttt agg aac ccc 18520 Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 2390 2395 2400 acg gtg gcg ccc acg cac gat gtg acc acc gac cgc agc cag cgg 18565 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg 2405 2410 2415 ctg acg ctg cgc ttc gtg ccc gtg gac cgc gag gac aac acc tac 18610 Leu Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr 2420 2425 2430 tcg tac aaa gtg cgc tac acg ctg gcc gtg ggc gac aac cgc gtg 18655 Ser Tyr Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val 2435 2440 2445 ctg gac atg gcc agc acc tac ttt gac atc cgc ggc gtg ctg gac 18700 Leu Asp Met Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp 2450 2455 2460 cgg ggc cct agc ttc aaa ccc tac tcc ggc acc gcc tac aac agc 18745 Arg Gly Pro Ser Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser 2465 2470 2475 ctg gct ccc aag gga gcg ccc aat tcc agc cag tgg gag cga gct 18790 Leu Ala Pro Lys Gly Ala Pro Asn Ser Ser Gln Trp Glu Arg Ala 2480 2485 2490 aag aca aac aat aac gga gcc acg gaa tct gtt acc ttt ggt gtg 18835 Lys Thr Asn Asn Asn Gly Ala Thr Glu Ser Val Thr Phe Gly Val 2495 2500 2505 gct gcc atg ggg ggt ata gat att aca aaa gag ggt ctc cag att 18880 Ala Ala Met Gly Gly Ile Asp Ile Thr Lys Glu Gly Leu Gln Ile 2510 2515 2520 gga act gat gaa act aaa gct gat agt aaa gaa att tat gca gac 18925 Gly Thr Asp Glu Thr Lys Ala Asp Ser Lys Glu Ile Tyr Ala Asp 2525 2530 2535 aaa acc tac caa cct gaa cct cag ata gga gag gag aac tgg caa 18970 Lys Thr Tyr Gln Pro Glu Pro Gln Ile Gly Glu Glu Asn Trp Gln 2540 2545 2550 gaa aca ttc tcc tat tat ggc ggc aga gct ctt aaa aaa gat acc 19015 Glu Thr Phe Ser Tyr Tyr Gly Gly Arg Ala Leu Lys Lys Asp Thr 2555 2560 2565 aag atg aag cca tgc tac ggc tcc ttt gct aaa cca acg aat gtc 19060 Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys Pro Thr Asn Val 2570 2575 2580 aaa gga ggt cag gcc aaa ttt aaa gtt cag gac ggt caa caa act 19105 Lys Gly Gly Gln Ala Lys Phe Lys Val Gln Asp Gly Gln Gln Thr 2585 2590 2595 aca gaa tat gat atc gac tta gct ttc ttt gat att cca aac tct 19150 Thr Glu Tyr Asp Ile Asp Leu Ala Phe Phe Asp Ile Pro Asn Ser 2600 2605 2610 gga aca gga ggg aat ggc acg aat gtt aat tat gat cca gat atg 19195 Gly Thr Gly Gly Asn Gly Thr Asn Val Asn Tyr Asp Pro Asp Met 2615 2620 2625 gtc atg tac act gaa aat gtg gat ttg gag acc cct gat acc cac 19240 Val Met Tyr Thr Glu Asn Val Asp Leu Glu Thr Pro Asp Thr His 2630 2635 2640 att gtt tac aaa cca ggg act tcc gat gac agt tct gaa gca aac 19285 Ile Val Tyr Lys Pro Gly Thr Ser Asp Asp Ser Ser Glu Ala Asn 2645 2650 2655 ttg ctt cag cag tcc atg cct aac aga ccc aac tat att ggg ttt 19330 Leu Leu Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe 2660 2665 2670 aga gac aac ttt atc ggt ctc atg tac tac aac agt act ggc aat 19375 Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn 2675 2680 2685 atg ggt gtg ctg gct ggt cag gcc tcc cag ctg aat gct gtg gtc 19420 Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val 2690 2695 2700 gac ttg caa gac aga aac acc gag cta tcc tac cag ctc ttg ctt 19465 Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu 2705 2710 2715 gac tct ctg ggc gat aga acc cgg tat ttc agt atg tgg aac cag 19510 Asp Ser Leu Gly Asp Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln 2720 2725 2730 gcg gtg gac agt tat gac cct gat gtg cgc att att gaa aac cat 19555 Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His 2735 2740 2745 ggt gtg gaa gat gaa ctt ccc aac tat tgc ttc cca ttg gat gga 19600 Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asp Gly 2750 2755 2760 gct ggt act aat gct gtc tat cag ggt gtt aaa gca aaa act aat 19645 Ala Gly Thr Asn Ala Val Tyr Gln Gly Val Lys Ala Lys Thr Asn 2765 2770 2775 gga ggc gca gcc aat gga gat tgg gag caa gat aca gac gtg tca 19690 Gly Gly Ala Ala Asn Gly Asp Trp Glu Gln Asp Thr Asp Val Ser 2780 2785 2790 aac att aac cag ata tgc aag ggg aac atc tat gcc atg gaa atc 19735 Asn Ile Asn Gln Ile Cys Lys Gly Asn Ile Tyr Ala Met Glu Ile 2795 2800 2805 aac ctc caa gcc aac ctg tgg aga agt ttc ctc tac tcg aac gtg 19780 Asn Leu Gln Ala Asn Leu Trp Arg Ser Phe Leu Tyr Ser Asn Val 2810 2815 2820 gcc ctg tac ctg ccc gat tct tac aag tac acg ccg gcc aac atc 19825 Ala Leu Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr Pro Ala Asn Ile 2825 2830 2835 acc ttg ccc acg aat acc aac acc tat gat tac atg aat ggg aga 19870 Thr Leu Pro Thr Asn Thr Asn Thr Tyr Asp Tyr Met Asn Gly Arg 2840 2845 2850 gtg gcg cct ccc tcg ttg gtg gat gcc tac atc aac atc ggg gcg 19915 Val Ala Pro Pro Ser Leu Val Asp Ala Tyr Ile Asn Ile Gly Ala 2855 2860 2865 cgc tgg tcg ctg gac ccc atg gac aac gtc aat ccc ttc aac cac 19960 Arg Trp Ser Leu Asp Pro Met Asp Asn Val Asn Pro Phe Asn His 2870 2875 2880 cac cgc aac gcg ggg ctg cgc tac cgc tcc atg ctt ctg ggc aac 20005 His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn 2885 2890 2895 ggg cgc ttc gtg ccc ttc cac atc cag gtg ccc cag aaa ttt ttc 20050 Gly Arg Phe Val Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe 2900 2905 2910 gcc atc aag agc ctc ctg ctc ctg ccc ggg tcc tac acc tac gag 20095 Ala Ile Lys Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu 2915 2920 2925 tgg aac ttc cgc aag gac gtc aac atg atc ctg cag agc tcc ctc 20140 Trp Asn Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu 2930 2935 2940 ggc aac gac ctg cgc acg gac ggg gcc tcc atc tcc ttc acc agc 20185 Gly Asn Asp Leu Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser 2945 2950 2955 atc aac ctc tac gcc acc ttc ttc ccc atg gcg cac aac acg gcc 20230 Ile Asn Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala 2960 2965 2970 tcc acg ctc gag gcc atg ctg cgc aac gac acc aac gac cag tcc 20275 Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser 2975 2980 2985 ttc aac gac tac ctc tcg gcg gcc aac atg ctc tac ccc atc cca 20320 Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro 2990 2995 3000 gcc aac gcc acc aac gtg ccc atc tcc atc ccc tcg cgc aac tgg 20365 Ala Asn Ala Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp 3005 3010 3015 gcc gcc ttc cgc ggc tgg tcc ttc acg cgt ctc aag acc aag gag 20410 Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu 3020 3025 3030 acg ccc tcg ctg ggc tcc ggg ttc gac ccc tac ttc gtc tac tcg 20455 Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser 3035 3040 3045 ggc tcc atc ccc tac ctc gac ggc acc ttc tac ctc aac cac acc 20500 Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr 3050 3055 3060 ttc aag aag gtc tcc atc acc ttc gac tcc tcc gtc agc tgg ccc 20545 Phe Lys Lys Val Ser Ile Thr Phe Asp Ser Ser Val Ser Trp Pro 3065 3070 3075 ggc aac gac cgg ctc ctg acg ccc aac gag ttc gaa atc aag cgc 20590 Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg 3080 3085 3090 acc gtc gac ggc gag ggc tac aac gtg gcc cag tgc aac atg acc 20635 Thr Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr 3095 3100 3105 aag gac tgg ttc ctg gtc cag atg ctg gcc cac tac aac atc ggc 20680 Lys Asp Trp Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly 3110 3115 3120 tac cag ggc ttc tac gtg ccc gag ggc tac aag gac cgc atg tac 20725 Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr 3125 3130 3135 tcc ttc ttc cgc aac ttc cag ccc atg agc cgc cag gtg gtg gac 20770 Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp 3140 3145 3150 gag gtc aac tac aag gac tac cag gcc gtc acc ctg gcc tac cag 20815 Glu Val Asn Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln 3155 3160 3165 cac aac aac tcg ggc ttc gtc ggc tac ctc gcg ccc acc atg cgc 20860 His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg 3170 3175 3180 cag ggc cag ccc tac ccc gcc aac tac ccg tac ccg ctc atc ggc 20905 Gln Gly Gln Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly 3185 3190 3195 aag agc gcc gtc acc agc gtc acc cag aaa aag ttc ctc tgc gac 20950 Lys Ser Ala Val Thr Ser Val Thr Gln Lys Lys Phe Leu Cys Asp 3200 3205 3210 agg gtc atg tgg cgc atc ccc ttc tcc agc aac ttc atg tcc atg 20995 Arg Val Met Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met 3215 3220 3225 ggc gcg ctc acc gac ctc ggc cag aac atg ctc tat gcc aac tcc 21040 Gly Ala Leu Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser 3230 3235 3240 gcc cac gcg cta gac atg aat ttc gaa gtc gac ccc atg gat gag 21085 Ala His Ala Leu Asp Met Asn Phe Glu Val Asp Pro Met Asp Glu 3245 3250 3255 tcc acc ctt ctc tat gtt gtc ttc gaa gtc ttc gac gtc gtc cga 21130 Ser Thr Leu Leu Tyr Val Val Phe Glu Val Phe Asp Val Val Arg 3260 3265 3270 gtg cac cag ccc cac cgc ggc gtc atc gag gcc gtc tac ctg cgc 21175 Val His Gln Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg 3275 3280 3285 acc ccc ttc tcg gcc ggt aac gcc acc acc taagctcttg cttcttgcaa g 21226 Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 3290 3295 atg gct gag ccc acg ggc tcc ggc gag cag gag ctc agg gcc atc 21271 Met Ala Glu Pro Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile 3300 3305 3310 atc cgc gac ctg ggc tgc ggg ccc tac ttc ctg ggc acc ttc gat 21316 Ile Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp 3315 3320 3325 aag cgc ttc ccg gga ttc atg gcc ccg cac aag ctg gcc tgc gcc 21361 Lys Arg Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala 3330 3335 3340 atc gtc aac acg gcc ggc cgc gag acc ggg ggc gag cac tgg ctg 21406 Ile Val Asn Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu 3345 3350 3355 gcc ttc gcc tgg aac ccg cgc tcg aac acc tgc tac ctc ttc gac 21451 Ala Phe Ala Trp Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp 3360 3365 3370 ccc ttc ggg ttc tcg gac gag cgc ctc aag cag atc tac cag ttc 21496 Pro Phe Gly Phe Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe 3375 3380 3385 gag tac gag ggc ctg ctg cgc cgc agc gcc ctg gcc acc gag gac 21541 Glu Tyr Glu Gly Leu Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp 3390 3395 3400 cgc tgc gtc acc ctg gaa aag tcc acc cag acc gtg cag ggt ccg 21586 Arg Cys Val Thr Leu Glu Lys Ser Thr Gln Thr Val Gln Gly Pro 3405 3410 3415 cgc tcg gcc gcc tgc ggg ctc ttt tgc tgc atg ttc ctg cac gcc 21631 Arg Ser Ala Ala Cys Gly Leu Phe Cys Cys Met Phe Leu His Ala 3420 3425 3430 ttc gtg cac tgg ccc gac cgc ccc atg gac aag aac ccc acc atg 21676 Phe Val His Trp Pro Asp Arg Pro Met Asp Lys Asn Pro Thr Met 3435 3440 3445 aac ttg ctg acg ggg gtg ccc aac ggc atg ctc cag tcg ccc cag 21721 Asn Leu Leu Thr Gly Val Pro Asn Gly Met Leu Gln Ser Pro Gln 3450 3455 3460 gtg gaa ccc acc ctg cgc cgc aac cag gag gcg ctc tac cgc ttc 21766 Val Glu Pro Thr Leu Arg Arg Asn Gln Glu Ala Leu Tyr Arg Phe 3465 3470 3475 ctc aac gcc cac tcc gcc tac ttt cgc tcc cac cgc gcg cgc atc 21811 Leu Asn Ala His Ser Ala Tyr Phe Arg Ser His Arg Ala Arg Ile 3480 3485 3490 gag aag gcc acc gcc ttc gac cgc atg aat caa gac atg taaaccgtgt 21860 Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Gln Asp Met 3495 3500 3505 gtgtatgtga atgctttatt cataataaac agcacatgtt tatgccacct tctctgaggc 21920 tctgacttta ttta gaa atc gaa ggg gtt ctg ccg gct ctc ggc gtg ccc 21970 Glu Ile Glu Gly Val Leu Pro Ala Leu Gly Val Pro 3510 3515 cgc ggg cag gga tac gtt gcg gaa ctg gta ctt ggg cag cca ctt 22015 Arg Gly Gln Gly Tyr Val Ala Glu Leu Val Leu Gly Gln Pro Leu 3520 3525 3530 gaa ctc ggg gat cag cag ctt cgg cac ggg gag gtc ggg gaa cga 22060 Glu Leu Gly Asp Gln Gln Leu Arg His Gly Glu Val Gly Glu Arg 3535 3540 3545 gtc gct cca cag ctt gcg cgt gag ttg cag ggc gcc cag cag gtc 22105 Val Ala Pro Gln Leu Ala Arg Glu Leu Gln Gly Ala Gln Gln Val 3550 3555 3560 ggg cgc gga gat ctt gaa atc gca gtt ggg acc cgc gtt ctg cgc 22150 Gly Arg Gly Asp Leu Glu Ile Ala Val Gly Thr Arg Val Leu Arg 3565 3570 3575 gcg aga gtt gcg gta cac ggg gtt gca gca ctg gaa cac cat cag 22195 Ala Arg Val Ala Val His Gly Val Ala Ala Leu Glu His His Gln 3580 3585 3590 ggc cgg gtg ctt cac gct cgc cag cac cgt cgc gtc ggt gat gcc 22240 Gly Arg Val Leu His Ala Arg Gln His Arg Arg Val Gly Asp Ala 3595 3600 3605 ctc cac gtc cag atc ctc ggc gtt ggc cat ccc gaa ggg ggt cat 22285 Leu His Val Gln Ile Leu Gly Val Gly His Pro Glu Gly Gly His 3610 3615 3620 ctt gca ggt ctg ccg ccc cat gct ggg cac gca gcc ggg ctt gtg 22330 Leu Ala Gly Leu Pro Pro His Ala Gly His Ala Ala Gly Leu Val 3625 3630 3635 gtt gca atc gca gtg cag ggg gat cag cat cat ctg ggc ctg ctc 22375 Val Ala Ile Ala Val Gln Gly Asp Gln His His Leu Gly Leu Leu 3640 3645 3650 gga gct cat gcc cgg gta cat ggc ctt cat gaa agc ctc cag ctg 22420 Gly Ala His Ala Arg Val His Gly Leu His Glu Ser Leu Gln Leu 3655 3660 3665 gcg gaa ggc ctg ctg cgc ctt gcc gcc ctc ggt gaa gaa gac ccc 22465 Ala Glu Gly Leu Leu Arg Leu Ala Ala Leu Gly Glu Glu Asp Pro 3670 3675 3680 gca gga ctt gct aga gaa ctg gtt ggt agc gca gcc cgc gtc gtg 22510 Ala Gly Leu Ala Arg Glu Leu Val Gly Ser Ala Ala Arg Val Val 3685 3690 3695 cac gca gca gcg cgc gtc gtt gtt ggc cag ctg cac cac gct gcg 22555 His Ala Ala Ala Arg Val Val Val Gly Gln Leu His His Ala Ala 3700 3705 3710 ccc cca gcg gtt ctg ggt gat ctt ggc ccg gtc ggg gtt ctc ctt 22600 Pro Pro Ala Val Leu Gly Asp Leu Gly Pro Val Gly Val Leu Leu 3715 3720 3725 cag cgc gcg ctg ccc gtt ctc gct cgc cac atc cat ctc gat cgt 22645 Gln Arg Ala Leu Pro Val Leu Ala Arg His Ile His Leu Asp Arg 3730 3735 3740 gtg ctc ctt ctg gat cat cac ggt ccc gtg cag gca ccg cag ctt 22690 Val Leu Leu Leu Asp His His Gly Pro Val Gln Ala Pro Gln Leu 3745 3750 3755 gcc ctc ggc ctc ggt gca gcc gtg cag cca cag cgc gca gcc ggt 22735 Ala Leu Gly Leu Gly Ala Ala Val Gln Pro Gln Arg Ala Ala Gly 3760 3765 3770 gct ctc cca gtt ctt gtg ggc gat ctg gga gtg cga gtg cac gaa 22780 Ala Leu Pro Val Leu Val Gly Asp Leu Gly Val Arg Val His Glu 3775 3780 3785 gcc ctg cag gaa gcg gcc cat cat cgc ggt cag ggt ctt gtt gct 22825 Ala Leu Gln Glu Ala Ala His His Arg Gly Gln Gly Leu Val Ala 3790 3795 3800 ggt gaa ggt cag cgg gat gcc gcg gtg ctc ctc gtt cac ata cag 22870 Gly Glu Gly Gln Arg Asp Ala Ala Val Leu Leu Val His Ile Gln 3805 3810 3815 gtg gca gat gcg gcg gta cac ctc gcc ctg ctc ggg cat cag ctg 22915 Val Ala Asp Ala Ala Val His Leu Ala Leu Leu Gly His Gln Leu 3820 3825 3830 gaa ggc gga ctt cag gtc gct ctc cac gcg gta ccg gtc cat cag 22960 Glu Gly Gly Leu Gln Val Ala Leu His Ala Val Pro Val His Gln 3835 3840 3845 cag cgt cat cac ttc cat gcc ctt ctc cca ggc cga aac gat cgg 23005 Gln Arg His His Phe His Ala Leu Leu Pro Gly Arg Asn Asp Arg 3850 3855 3860 cag gct cag ggg gtt ctt cac cgt cat ctt agt cgc cgc cgc cga 23050 Gln Ala Gln Gly Val Leu His Arg His Leu Ser Arg Arg Arg Arg 3865 3870 3875 agt cag ggg gtc gtt ctc gtc cag ggt ctc aaa cac tcg ctt gcc 23095 Ser Gln Gly Val Val Leu Val Gln Gly Leu Lys His Ser Leu Ala 3880 3885 3890 gtc ctt ctc ggt gat gcg cac ggg ggg gaa ggc gaa gcc cac ggc 23140 Val Leu Leu Gly Asp Ala His Gly Gly Glu Gly Glu Ala His Gly 3895 3900 3905 cgc cag ctc ctc ctc ggc ctg cct ttc gtc ctc gct gtc ctg gct 23185 Arg Gln Leu Leu Leu Gly Leu Pro Phe Val Leu Ala Val Leu Ala 3910 3915 3920 gat gtc ttg caa agg cac atg ctt ggt ctt gcg ggg ttt ctt ttt 23230 Asp Val Leu Gln Arg His Met Leu Gly Leu Ala Gly Phe Leu Phe 3925 3930 3935 ggg cgg cag agg cgg cgg cgg cgg aga cgt gct ggg cga gcg cga 23275 Gly Arg Gln Arg Arg Arg Arg Arg Arg Arg Ala Gly Arg Ala Arg 3940 3945 3950 gtt ctc gct cac cac gac tat ttc ttc ttc ttg gcc gtc gtc cga 23320 Val Leu Ala His His Asp Tyr Phe Phe Phe Leu Ala Val Val Arg 3955 3960 3965 gac cac gcg gcg gta ggc atg cct ctt ctg ggg cag agg cgg agg 23365 Asp His Ala Ala Val Gly Met Pro Leu Leu Gly Gln Arg Arg Arg 3970 3975 3980 cga cgg gct ctc gcg gtt cgg cgg gcg gct ggc aga gcc cct tcc 23410 Arg Arg Ala Leu Ala Val Arg Arg Ala Ala Gly Arg Ala Pro Ser 3985 3990 3995 gcg ttc ggg ggt gcg ctc ctg gcg gcg ctg ctc tga ctg act tcc 23455 Ala Phe Gly Gly Ala Leu Leu Ala Ala Leu Leu Leu Thr Ser 4000 4005 4010 tcc gcg gcc ggc cat tgtgttctcc tagggagcaa caacaagcat ggagactcag 23510 Ser Ala Ala Gly His 4015 ccatcgtcgc caacatcgcc atctgccccc gccgccgccg acgagaacca gcagcagcag 23570 aatgaaagct taaccgcccc gccgcccagc cccacctccg acgccgcggc cccagacatg 23630 caagagatgg aggaatccat cgagattgac ctgggctacg tgacgcccgc ggagcacgag 23690 gaggagctgg cagcgcgctt ttcagccccg gaagagaacc accaagagca gccagagcag 23750 gaagcagaga gcgagcagag ccaggctggg ctcgagcatg gcgactacct gagcggggca 23810 gaggacgtgc tcatcaagca tctggcccgc caatgcatca tcgtcaagga cgcgctgctc 23870 gaccgcgccg aggtgcccct cagcgtggcg gagctcagcc gcgcctacga gcgcaacctc 23930 ttctcgccgc gcgtgccccc caagcgccag cccaacggca cctgcgagcc caacccgcgc 23990 ctcaacttct acccggtctt cgcggtgccc gaggccctgg ccacctacca cctctttttc 24050 aagaaccaaa ggatccccgt ctcctgccgc gccaaccgca cccgcgccga cgccctgctc 24110 aacctgggcc ccggcgcccg cctacctgat atcgcctcct tggaagaggt tcccaagatc 24170 ttcgagggtc tgggcagcga cgagactcgg gccgcgaacg ctctgcaagg aagcggagag 24230 gagcatgagc accacagcgc cctggtggag ttggaaggcg acaacgcgcg cctggcggtc 24290 ctcaagcgca cggtcgagct gacccacttc gcctacccgg cgctcaacct gccccccaag 24350 gtcatgagcg ccgtcatgga ccaggtgctc atcaagcgcg cctcgcccct ctcggaggag 24410 gagatgcagg accccgagag ctcggacgag ggcaagcccg tggtcagcga cgagcagctg 24470 gcgcgctggc tgggaacgag tagcaccccc cagagtctgg aagagcggcg caagctcatg 24530 atggccgtgg tcctggtgac cgtggagctt gagtgtctgc gccgcttctt cgccgacgcg 24590 gagaccctgc gcaaggtcga ggagaacctg cactacctct tcaggcacgg gttcgtgcgc 24650 caggcctgca agatctccaa cgtggagctg accaacctgg tctcctacat gggcatcctg 24710 cacgagaacc gcctggggca gaacgtgctg cacaccaccc tgcgcgggga ggcccgccgc 24770 gactacatcc gcgactgcgt ctacctgtac ctctgccaca cctggcagac gggcatgggc 24830 gtgtggcagc agtgcctgga ggagcagaac ctgaaagagc tctgcaagct cctgcagaag 24890 aacctgaagg ccctgtggac cgggttcgac gagcgtacca ccgcctcgga cctggccgac 24950 ctcatcttcc ccgagcgcct gcggctgacg ctgcgcaacg ggctgcccga ctttatgagc 25010 caaagcatgt tgcaaaactt tcgctctttc atcctcgaac gctccgggat cctgcccgcc 25070 acctgctccg cgctgccctc ggacttcgtg ccgctgacct tccgcgagtg ccccccgccg 25130 ctctggagcc actgctactt gctgcgcctg gccaactacc tggcctacca ctcggacgtg 25190 atcgaggacg tcagcggcga gggtctgctc gagtgccact gccgctgcaa cctctgcacg 25250 ccgcaccgct ccctggcctg caacccccag ctgctgagcg agacccagat catcggcacc 25310 ttcgagttgc aaggccccgg cgaggagggc aaggggggtc tgaaactcac cccggggctg 25370 tggacctcgg cctacttgcg caagttcgtg cccgaggact accatccctt cgagatcagg 25430 ttctacgagg accaatccca gccgcccaag gccgagctgt cggcctgcgt catcacccag 25490 ggggccatcc tggcccaatt gcaagccatc cagaaatccc gccaagaatt tctgctgaaa 25550 aagggccacg gggtctactt ggacccccag accggagagg agctcaaccc cagcttcccc 25610 cagg atg ccc aga gga agc agc aag aag ctg aaa gtg gag ctg ccg 25656 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro 4020 4025 4030 ctg ccg ccg gag gat ttg gag gaa gac tgg gag agc agt cag gca 25701 Leu Pro Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala 4035 4040 4045 gag gag gag gag atg gaa gac tgg gac agc act cag gca gag gag 25746 Glu Glu Glu Glu Met Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu 4050 4055 4060 gac agc ctg caa gac agt ctg gaa gac gag gtg gag gag gca gag 25791 Asp Ser Leu Gln Asp Ser Leu Glu Asp Glu Val Glu Glu Ala Glu 4065 4070 4075 gaa gaa gca gcc gcc gcc aga ccg tcg tcc tcg gcg gag aaa gca 25836 Glu Glu Ala Ala Ala Ala Arg Pro Ser Ser Ser Ala Glu Lys Ala 4080 4085 4090 agc agc acg gat acc atc tcc gct ccg ggt cgg ggt ctc ggc ggc 25881 Ser Ser Thr Asp Thr Ile Ser Ala Pro Gly Arg Gly Leu Gly Gly 4095 4100 4105 cgg gcc cac agt aga tgg gac gag acc ggg cgc ttc ccg aac ccc 25926 Arg Ala His Ser Arg Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro 4110 4115 4120 acc acc cag acc ggt aag aag gag cgg cag gga tac aag tcc tgg 25971 Thr Thr Gln Thr Gly Lys Lys Glu Arg Gln Gly Tyr Lys Ser Trp 4125 4130 4135 cgg ggg cac aaa aac gcc atc gtc tcc tgc ttg caa gcc tgc ggg 26016 Arg Gly His Lys Asn Ala Ile Val Ser Cys Leu Gln Ala Cys Gly 4140 4145 4150 ggc aac atc tcc ttc acc cgg cgc tac ctg ctc ttc cac cgc ggg 26061 Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu Leu Phe His Arg Gly 4155 4160 4165 gtg aac ttc ccc cgc aac atc ttg cat tac tac cgt cac ctc cac 26106 Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr Arg His Leu His 4170 4175 4180 agc ccc tac tac tgt ttc caa gaa gag gca gaa acc cag cag cag 26151 Ser Pro Tyr Tyr Cys Phe Gln Glu Glu Ala Glu Thr Gln Gln Gln 4185 4190 4195 cag aaa acc agc agc agc tagaaaatcc acagcggcgg cggcggcagg 26199 Gln Lys Thr Ser Ser Ser 4200 tggactgagg atcgcggcga acgagccggc gcagacccgg gagctgagga accggatctt 26259 tcccaccctc tatgccatct tccagcagag tcgggggcag gagcaggaac tgaaagtcaa 26319 gaaccgttct ctgcgctcgc tcacccgcag ttgtctgtat cacaagagcg aagaccaact 26379 tcagcgcact ctcgaggacg ccgaggctct cttcaacaag tactgcgcgc tcactcttaa 26439 agagtagccc gcgcccgccc acacacggaa aaaggcggga attacgtcac cacctgcgcc 26499 cttcgcccga ccatcatc atg agc aaa gag att ccc acg cct tac atg tgg 26550 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp 4205 4210 agc tac cag ccc cag atg ggc ctg gcc gcc ggc gcc gcc cag gac 26595 Ser Tyr Gln Pro Gln Met Gly Leu Ala Ala Gly Ala Ala Gln Asp 4215 4220 4225 tac tcc acc cgc atg aac tgg ctc agt gcc ggg ccc gcg atg atc 26640 Tyr Ser Thr Arg Met Asn Trp Leu Ser Ala Gly Pro Ala Met Ile 4230 4235 4240 tca cgg gtg aat gac atc cgc gcc cac cga aac cag ata ctc cta 26685 Ser Arg Val Asn Asp Ile Arg Ala His Arg Asn Gln Ile Leu Leu 4245 4250 4255 gaa cag tca gcg atc acc gcc acg ccc cgc cat cac ctt aat ccg 26730 Glu Gln Ser Ala Ile Thr Ala Thr Pro Arg His His Leu Asn Pro 4260 4265 4270 cgt aat tgg ccc gcc gcc ctg gtg tac cag gaa att ccc cag ccc 26775 Arg Asn Trp Pro Ala Ala Leu Val Tyr Gln Glu Ile Pro Gln Pro 4275 4280 4285 acg acc gta cta ctt ccg cga gac gcc cag gcc gaa gtc cag ctg 26820 Thr Thr Val Leu Leu Pro Arg Asp Ala Gln Ala Glu Val Gln Leu 4290 4295 4300 act aac tca ggt gtc cag ctg gcc ggc ggc gcc gcc ctg tgt cgt 26865 Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala Ala Leu Cys Arg 4305 4310 4315 cac cgc ccc gct cag ggt ata aag cgg ctg gtg atc cga ggc aga 26910 His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile Arg Gly Arg 4320 4325 4330 ggc aca cag ctc aac gac gag gtg gtg agc tct tcg ctg ggt ctg 26955 Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu Gly Leu 4335 4340 4345 cga cct gac gga gtc ttc caa ctc gcc gga tcg ggg aga tct tcc 27000 Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser Ser 4350 4355 4360 ttc acg cct cgt cag gcc gtc ctg act ttg gag agt tcg tcc tcg 27045 Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 4365 4370 4375 cag ccc cgc tcg ggt ggc atc ggc act ctc cag ttc gtg gag gag 27090 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu 4380 4385 4390 ttc act ccc tcg gtc tac ttc aac ccc ttc tcc ggc tcc ccc ggc 27135 Phe Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly 4395 4400 4405 cac tac ccg gac gag ttc atc ccg aac ttc gac gcc atc agc gag 27180 His Tyr Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu 4410 4415 4420 tcg gtg gac ggc tac gat tga atg tcc cat ggt ggc gcg gct gac 27225 Ser Val Asp Gly Tyr Asp Met Ser His Gly Gly Ala Ala Asp 4425 4430 4435 cta gct cgg ctt cga cac ctg gac cac tgc cgc cgc ttc cgc tgc 27270 Leu Ala Arg Leu Arg His Leu Asp His Cys Arg Arg Phe Arg Cys 4440 4445 4450 ttc gct cgg gat ctc gcc gag ttt gcc tac ttt gag ctg ccc gag 27315 Phe Ala Arg Asp Leu Ala Glu Phe Ala Tyr Phe Glu Leu Pro Glu 4455 4460 4465 gag cac cct cag ggc ccg gcc cac gga gtg cgg atc atc gtc gaa 27360 Glu His Pro Gln Gly Pro Ala His Gly Val Arg Ile Ile Val Glu 4470 4475 4480 ggg ggc ctc gac tcc cac ctg ctt cgg atc ttc agc cag cgt ccg 27405 Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe Ser Gln Arg Pro 4485 4490 4495 atc ctg gtc gag cgc gag caa gga cag acc cgt ctg acc ctg tac 27450 Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Arg Leu Thr Leu Tyr 4500 4505 4510 tgc atc tgc aac cac ccc ggc ctg cat gaa agt ctt tgt tgt ctg 27495 Cys Ile Cys Asn His Pro Gly Leu His Glu Ser Leu Cys Cys Leu 4515 4520 4525 ctg tgt act gag tat aat aaa agc tgagatcagc gactactccg 27539 Leu Cys Thr Glu Tyr Asn Lys Ser 4530 4535 gacttccgtg tgttcctgaa tccatcaacc agtccctgtt cttcaccggg aacgagaccg 27599 agctccagct ccagtgtaag ccccacaaga agtacctcac ctggctgttc cagggctccc 27659 cgatcgccgt tgtcaaccac tgcgacaacg acggagtcct gctgagcggc cctgccaacc 27719 ttactttttc cacccgcaga agcaagctcc agctcttcca acccttcctc cccgggacct 27779 atcagtgcgt ctcgggaccc tgccatcaca ccttccacct gatcccgaat accacagcgt 27839 cgctccccgc tactaacaac caaactaccc accaacgcca ccgtcgcgac ctttcctctg 27899 aatctaatac cactaccgga ggtgagctcc gaggtcgacc aacctctggg atttactacg 27959 gcccctggga ggtggtgggg ttaatagcgc taggcctagt tgtgggtggg cttttggctc 28019 tctgctacct atacctccct tgctgttcgt acttagtggt gctgtgttgc tggtttaaga 28079 a atg ggg cag atc acc cta gtg agc tgc ggt gtg ctg gtg gcg gtg 28125 Met Gly Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val 4540 4545 4550 gtg ctt tcg att gtg gga ctg ggc ggc gcg gct gta gtg aag gag 28170 Val Leu Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu 4555 4560 4565 aag gcc gat ccc tgc ttg cat ttc aat ccc gat aaa tgc cag ctg 28215 Lys Ala Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu 4570 4575 4580 agt ttt cag ccc gat ggc aat cgg tgc gcg gtg ctg atc aag tgc 28260 Ser Phe Gln Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys 4585 4590 4595 gga tgg gaa tgc gag aac gtg aga atc gag tac aat aac aag act 28305 Gly Trp Glu Cys Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr 4600 4605 4610 cgg aac aat act ctc gcg tcc acg tgg cag ccc ggg gac ccc gag 28350 Arg Asn Asn Thr Leu Ala Ser Thr Trp Gln Pro Gly Asp Pro Glu 4615 4620 4625 tgg tac acc gtc tct gtc ccc ggt gct gac ggc tcc ccg cgc acc 28395 Trp Tyr Thr Val Ser Val Pro Gly Ala Asp Gly Ser Pro Arg Thr 4630 4635 4640 gtg aat aat act ttc att ttt gcg cac atg tgc gac acg gtc atg 28440 Val Asn Asn Thr Phe Ile Phe Ala His Met Cys Asp Thr Val Met 4645 4650 4655 tgg atg agc aag cag tac gat atg tgg ccc ccc acg aag gag aac 28485 Trp Met Ser Lys Gln Tyr Asp Met Trp Pro Pro Thr Lys Glu Asn 4660 4665 4670 atc gtg gtc ttc tcc atc gct tac agc ctg tgc acg gtg cta atc 28530 Ile Val Val Phe Ser Ile Ala Tyr Ser Leu Cys Thr Val Leu Ile 4675 4680 4685 acc gct atc gtg tgc ctg agc att cac atg ctc atc gct att cgc 28575 Thr Ala Ile Val Cys Leu Ser Ile His Met Leu Ile Ala Ile Arg 4690 4695 4700 ccc aga aat aat gcc gaa aaa gaa aaa cag cca taacacgttt 28618 Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 4705 4710 tttcacacac ctttttcaga cc atg gcc tct gtt aaa ttt ttg ctt tta 28667 Met Ala Ser Val Lys Phe Leu Leu Leu 4715 4720 ttt gcc agt ctc att act gtt ata agt aat gag aaa ctc act att 28712 Phe Ala Ser Leu Ile Thr Val Ile Ser Asn Glu Lys Leu Thr Ile 4725 4730 4735 tac att ggc act aac cac act cta gaa gga att cca aaa tcc tca 28757 Tyr Ile Gly Thr Asn His Thr Leu Glu Gly Ile Pro Lys Ser Ser 4740 4745 4750 tgg tat tgc tat ttt gat caa gat cca gac tta act ata gaa ctg 28802 Trp Tyr Cys Tyr Phe Asp Gln Asp Pro Asp Leu Thr Ile Glu Leu 4755 4760 4765 tgt ggt aac aag gga caa aat aca agc att cat tta att aac ttt 28847 Cys Gly Asn Lys Gly Gln Asn Thr Ser Ile His Leu Ile Asn Phe 4770 4775 4780 aaa tgc gga gac gat ttg aaa tta att aat atc act aaa gag tat 28892 Lys Cys Gly Asp Asp Leu Lys Leu Ile Asn Ile Thr Lys Glu Tyr 4785 4790 4795 gga ggt atg tat tac tat gtt aca gaa aat aac aac atg cag ttt 28937 Gly Gly Met Tyr Tyr Tyr Val Thr Glu Asn Asn Asn Met Gln Phe 4800 4805 4810 tat gaa gtt act gta act aat ccc acc acg cct aga aca aca aca 28982 Tyr Glu Val Thr Val Thr Asn Pro Thr Thr Pro Arg Thr Thr Thr 4815 4820 4825 acc acc aca aag act aca cct gtt acc act atg cag ctc act acc 29027 Thr Thr Thr Lys Thr Thr Pro Val Thr Thr Met Gln Leu Thr Thr 4830 4835 4840 aat aac att ttt gcc atg cgt cag aag gcc aac aat agc acc agc 29072 Asn Asn Ile Phe Ala Met Arg Gln Lys Ala Asn Asn Ser Thr Ser 4845 4850 4855 att caa ccc ccc cca ccc agt gag gaa att ccc aaa tcc atg att 29117 Ile Gln Pro Pro Pro Pro Ser Glu Glu Ile Pro Lys Ser Met Ile 4860 4865 4870 ggc att att gtt gct gta gtg gtg tgc atg ttg atc atc gcc ttg 29162 Gly Ile Ile Val Ala Val Val Val Cys Met Leu Ile Ile Ala Leu 4875 4880 4885 tgc atg gtg tac tat gcc ttc tgc tac aga aag cac aga ctg aac 29207 Cys Met Val Tyr Tyr Ala Phe Cys Tyr Arg Lys His Arg Leu Asn 4890 4895 4900 gac aag cta gaa cac tta cta agt gtt gaa ttt taattttttt 29250 Asp Lys Leu Glu His Leu Leu Ser Val Glu Phe 4905 4910 agaaccatga agatcctagg ccttttaatt ttttctatca ttacctctgc tctatgcaat 29310 tctgacaatg aggacgttac tgtcgttgtc ggatcaaatt atacactgaa aggtccagcg 29370 aagggtatgc tttcgtggta ttgctggttt ggaactgaca ctgaacaaac cgaattatgc 29430 aatcttcaaa atggcaaagt tcataattct aaaatttaca attatatatg caatggcact 29490 gatttgatac tcctcaatat cacgaaatca tatgctggca gttattcatg ccctggagat 29550 gatgctgaca atatgatttt ttataaattg caagtggttg atcccactac tccacctcca 29610 cccaccacaa ctactcacac cacacacaca gaacaaacca cagcagagga ggcggcaaag 29670 ttagctttgc aggtccaaga cagttcattt gttggcatta cccctacacc cgatcagcgg 29730 tgtccggggc tgctcgtcag cggcattgtc ggtgtgcttt cgggattagc agttataatc 29790 atctgcatgt tcatttttgc ttgctgctat agaaggcttt accgacaaaa atcagaccca 29850 ctgctgaacc tctatgttta attttttcca gagcc atg aag gca gtt agc gct 29903 Met Lys Ala Val Ser Ala 4915 cta gtt ttt tgt tct ttg att ggc act gtt ttt agt gtt agc ttt 29948 Leu Val Phe Cys Ser Leu Ile Gly Thr Val Phe Ser Val Ser Phe 4920 4925 4930 tta aaa caa att aat gtt act gag ggg gaa aat gtg aca ctg gta 29993 Leu Lys Gln Ile Asn Val Thr Glu Gly Glu Asn Val Thr Leu Val 4935 4940 4945 ggc gta gaa ggt gct caa aat acc acc tgg aca aaa tac cac ctc 30038 Gly Val Glu Gly Ala Gln Asn Thr Thr Trp Thr Lys Tyr His Leu 4950 4955 4960 gat ggg tgg aaa gat att tgc aat tgg agt gtc att act tac aca 30083 Asp Gly Trp Lys Asp Ile Cys Asn Trp Ser Val Ile Thr Tyr Thr 4965 4970 4975 tgt gag gga gtt aat ttg acc ata gtc aat gcc agc caa aat cag 30128 Cys Glu Gly Val Asn Leu Thr Ile Val Asn Ala Ser Gln Asn Gln 4980 4985 4990 aag ggt tgg att aaa ggg caa tct gtt agt gtt acc agt gag ggg 30173 Lys Gly Trp Ile Lys Gly Gln Ser Val Ser Val Thr Ser Glu Gly 4995 5000 5005 tac tat acc cag cat act ctt atc tat gac att ata gtc ata ccg 30218 Tyr Tyr Thr Gln His Thr Leu Ile Tyr Asp Ile Ile Val Ile Pro 5010 5015 5020 ctg cct acg cct agc cca cct agc act acc aca cag aca acc cac 30263 Leu Pro Thr Pro Ser Pro Pro Ser Thr Thr Thr Gln Thr Thr His 5025 5030 5035 act aca caa aca acc aca tac agt aca tca aat cag cct acc acc 30308 Thr Thr Gln Thr Thr Thr Tyr Ser Thr Ser Asn Gln Pro Thr Thr 5040 5045 5050 act aca aca gca gag gtt gcc agc tcg tct ggg gtc cga gcg gca 30353 Thr Thr Thr Ala Glu Val Ala Ser Ser Ser Gly Val Arg Ala Ala 5055 5060 5065 ttt ttg atg ttg gcc cca tct agc agt ccc act gct agt acc aat 30398 Phe Leu Met Leu Ala Pro Ser Ser Ser Pro Thr Ala Ser Thr Asn 5070 5075 5080 gag cag act act gaa ttt ttg tcc act gtc gag agc cac acc aca 30443 Glu Gln Thr Thr Glu Phe Leu Ser Thr Val Glu Ser His Thr Thr 5085 5090 5095 gct acc tcg agt gcc ttc tct agc acc gcc aat ctc tcc tcg ctt 30488 Ala Thr Ser Ser Ala Phe Ser Ser Thr Ala Asn Leu Ser Ser Leu 5100 5105 5110 tcc tct aca cca atc agt ccc gct act act act acc ccc gct att 30533 Ser Ser Thr Pro Ile Ser Pro Ala Thr Thr Thr Thr Pro Ala Ile 5115 5120 5125 ctt ccc act ccc ctg aag caa act gag gac agc ggc atg caa tgg 30578 Leu Pro Thr Pro Leu Lys Gln Thr Glu Asp Ser Gly Met Gln Trp 5130 5135 5140 cag atc acc ctg ctc att gtg atc ggg ttg gtc atc cta gcc gtg 30623 Gln Ile Thr Leu Leu Ile Val Ile Gly Leu Val Ile Leu Ala Val 5145 5150 5155 ttg ctc tac tac atc ttc cgc cgc cgc att ccc aac gcg cac cgc 30668 Leu Leu Tyr Tyr Ile Phe Arg Arg Arg Ile Pro Asn Ala His Arg 5160 5165 5170 aag ccg gtc tac aag ccc atc att gtc ggg cag ccg gag ccg ctt 30713 Lys Pro Val Tyr Lys Pro Ile Ile Val Gly Gln Pro Glu Pro Leu 5175 5180 5185 cag gtg gaa ggg ggt cta agg aat ctt ctc ttc tct ttt aca gta 30758 Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser Phe Thr Val 5190 5195 5200 tgg tgattgaact atgattccta gacaattctt gatcactatt cttatctgcc 30811 Trp tcctccaagt ctgtgccacc ctcgctctgg tggccaacgc cagtccagac tgtattgggc 30871 ccttcgcctc ctacgtgctc tttgccttca tcacctgcat ctgctgctgt agcatagtct 30931 gcctgcttat caccttcttc cagttcattg actggatctt tgtgcgcatc gcctacctgc 30991 gccaccaccc ccagtaccgc gaccagcgag tggcgcagct gctcaggctc ctctgataag 31051 catgcgggct ctgctacttc tcgcgcttct gctgttagtg ctcccccgtc ccgttgaccc 31111 ccggcccccc actcagtccc ccgaggaggt ccgcaaatgc aaattccaag aaccctggaa 31171 attcctcaaa tgctaccgcc aaaaatcaga catgcatccc agctggatca tgatcattgg 31231 gatcgtgaac attctggcct gcaccctcat ctcctttgtg atttacccct gctttgactt 31291 tggttggaac tcgccagagg cgctctatct cccgcctgaa cctgacacac caccacagca 31351 acctcaggca cacgcactac caccaccaca gcctaggcca caatacatgc ccatattaga 31411 ctatgaggcc gagccacagc gacccatgct ccccgctatt agttacttca atctaaccgg 31471 cggag atg act gac cca ctg gcc aac aac aac gtc aac gac ctt ctc 31518 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu Leu 5205 5210 5215 ctg gac atg gac ggc cgc gcc tcg gag cag cga ctc gcc caa ctt 31563 Leu Asp Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu 5220 5225 5230 cgc att cgc cag cag cag gag aga gcc gtc aag gag ctg cag gac 31608 Arg Ile Arg Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp 5235 5240 5245 ggc ata gcc atc cac cag tgc aag aaa ggc atc ttc tgc ctg gtg 31653 Gly Ile Ala Ile His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val 5250 5255 5260 aaa cag gcc aag atc tcc tac gag gtc acc cag acc gac cat cgc 31698 Lys Gln Ala Lys Ile Ser Tyr Glu Val Thr Gln Thr Asp His Arg 5265 5270 5275 ctc tcc tac gag ctc ctg cag cag cgc cag aag ttc acc tgc ctg 31743 Leu Ser Tyr Glu Leu Leu Gln Gln Arg Gln Lys Phe Thr Cys Leu 5280 5285 5290 gtc gga gtc aac ccc atc gtc atc acc cag cag tcg ggc gat acc 31788 Val Gly Val Asn Pro Ile Val Ile Thr Gln Gln Ser Gly Asp Thr 5295 5300 5305 aag ggg tgc atc cac tgc tcc tgc gac tcc ccc gac tgc gtc cac 31833 Lys Gly Cys Ile His Cys Ser Cys Asp Ser Pro Asp Cys Val His 5310 5315 5320 act ctg atc aag acc ctc tgc ggc ctc cgc gac ctc ctc ccc atg 31878 Thr Leu Ile Lys Thr Leu Cys Gly Leu Arg Asp Leu Leu Pro Met 5325 5330 5335 aac taatcacccc cttatccagt gaaataaaga tcatattgat gattaaataa 31931 Asn aaaaaataat catttgattt gaaataaaga tacaatcata ttgatgattt gagtttaata 31991 aaaataaaga atcacttact tgaaatctga taccaggtct ctgtccatgt tttctgccaa 32051 caccacttca ctcccctctt cccagctctg gtactgcagg ccccggcggg ctgcaaactt 32111 cctccacacc ctgaagggga tgtcaaattc ctcctgtccc tcaatcttca ttttatcttc 32171 tatcag atg tcc aaa aag cgc gtc cgg gtg gat gat gac ttc gac ccc 32219 Met Ser Lys Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro 5340 5345 5350 gtc tac ccc tac gat gca gac aac gca ccg acc gtg ccc ttc atc 32264 Val Tyr Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile 5355 5360 5365 aac ccc ccc ttc gtc tct tca gat gga ttc caa gag aag ccc ctg 32309 Asn Pro Pro Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu 5370 5375 5380 ggg gtg ctg tcc ctg cgt ctg gcc gat ccc gtc acc acc aag aac 32354 Gly Val Leu Ser Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn 5385 5390 5395 ggg gaa atc acc ctc aag ctg gga gat ggg gtg gac ctc gac tcc 32399 Gly Glu Ile Thr Leu Lys Leu Gly Asp Gly Val Asp Leu Asp Ser 5400 5405 5410 tcg gga aaa ctc atc tcc aac acg gcc acc aag gcc gcc gcc cct 32444 Ser Gly Lys Leu Ile Ser Asn Thr Ala Thr Lys Ala Ala Ala Pro 5415 5420 5425 ctc agt ttt tcc aac aac acc att tcc ctt aac atg gat acc cct 32489 Leu Ser Phe Ser Asn Asn Thr Ile Ser Leu Asn Met Asp Thr Pro 5430 5435 5440 ttt tac aac aac aat gga aag tta ggc atg aaa gtc act gct cca 32534 Phe Tyr Asn Asn Asn Gly Lys Leu Gly Met Lys Val Thr Ala Pro 5445 5450 5455 ctg aag ata cta gac aca gac ttg cta aaa aca ctt gtt gta gct 32579 Leu Lys Ile Leu Asp Thr Asp Leu Leu Lys Thr Leu Val Val Ala 5460 5465 5470 tat gga caa ggt tta gga aca aac acc act ggt gcc ctt gtt gcc 32624 Tyr Gly Gln Gly Leu Gly Thr Asn Thr Thr Gly Ala Leu Val Ala 5475 5480 5485 caa cta gca tcc cca ctt gct ttt gat agc aat agc aaa att gcc 32669 Gln Leu Ala Ser Pro Leu Ala Phe Asp Ser Asn Ser Lys Ile Ala 5490 5495 5500 ctt aat tta ggc aat gga cca ttg aaa gtg gat gca aat aga ctg 32714 Leu Asn Leu Gly Asn Gly Pro Leu Lys Val Asp Ala Asn Arg Leu 5505 5510 5515 aac atc aat tgc aat aga gga ctc tat gtt act acc aca aaa gat 32759 Asn Ile Asn Cys Asn Arg Gly Leu Tyr Val Thr Thr Thr Lys Asp 5520 5525 5530 gca ctg gaa gcc aat ata agt tgg gct aat gct atg aca ttt ata 32804 Ala Leu Glu Ala Asn Ile Ser Trp Ala Asn Ala Met Thr Phe Ile 5535 5540 5545 gga aat gcc atg ggt gtc aat att gat aca caa aaa ggc ttg caa 32849 Gly Asn Ala Met Gly Val Asn Ile Asp Thr Gln Lys Gly Leu Gln 5550 5555 5560 ttt ggc acc act agt acc gtc gca gat gtt aaa aac gct tac ccc 32894 Phe Gly Thr Thr Ser Thr Val Ala Asp Val Lys Asn Ala Tyr Pro 5565 5570 5575 ata caa atc aaa ctt gga gct ggt ctc aca ttt gac agc aca ggt 32939 Ile Gln Ile Lys Leu Gly Ala Gly Leu Thr Phe Asp Ser Thr Gly 5580 5585 5590 gca att gtt gca tgg aac aaa gat gat gac aag ctt aca cta tgg 32984 Ala Ile Val Ala Trp Asn Lys Asp Asp Asp Lys Leu Thr Leu Trp 5595 5600 5605 acc aca gcc gac ccc tct cca aat tgt cac ata tat tct gaa aag 33029 Thr Thr Ala Asp Pro Ser Pro Asn Cys His Ile Tyr Ser Glu Lys 5610 5615 5620 gat gct aag ctt aca ctt tgc ttg aca aag tgt ggc agt cag att 33074 Asp Ala Lys Leu Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile 5625 5630 5635 ctg ggc act gtt tcc ctc ata gct gtt gat act ggc agt tta aat 33119 Leu Gly Thr Val Ser Leu Ile Ala Val Asp Thr Gly Ser Leu Asn 5640 5645 5650 ccc ata aca gga aca gta acc act gct ctt gtc tca ctt aaa ttc 33164 Pro Ile Thr Gly Thr Val Thr Thr Ala Leu Val Ser Leu Lys Phe 5655 5660 5665 gat gca aat gga gtt ttg caa agc agc tca aca cta gac tca gac 33209 Asp Ala Asn Gly Val Leu Gln Ser Ser Ser Thr Leu Asp Ser Asp 5670 5675 5680 tat tgg aat ttc aga cag gga gat gtt aca cct gct gaa gcc tat 33254 Tyr Trp Asn Phe Arg Gln Gly Asp Val Thr Pro Ala Glu Ala Tyr 5685 5690 5695 act aat gct ata ggt ttc atg ccc aat cta aaa gca tac cct aaa 33299 Thr Asn Ala Ile Gly Phe Met Pro Asn Leu Lys Ala Tyr Pro Lys 5700 5705 5710 aac aca agt gga gct gca aaa agt cac att gtt ggg aaa gtg tac 33344 Asn Thr Ser Gly Ala Ala Lys Ser His Ile Val Gly Lys Val Tyr 5715 5720 5725 cta cat ggg gat aca gac aaa cca ctg gac ctc att att act ttc 33389 Leu His Gly Asp Thr Asp Lys Pro Leu Asp Leu Ile Ile Thr Phe 5730 5735 5740 aat gaa aca agt gat gaa tct tgc act tac tgt att aac ttt caa 33434 Asn Glu Thr Ser Asp Glu Ser Cys Thr Tyr Cys Ile Asn Phe Gln 5745 5750 5755 tgg cag tgg ggg gct gat caa tat aaa aat gaa aca ctt gcc gtc 33479 Trp Gln Trp Gly Ala Asp Gln Tyr Lys Asn Glu Thr Leu Ala Val 5760 5765 5770 agt tca ttc acc ttt tcc tat att gct aaa gaa taaaccccac 33522 Ser Ser Phe Thr Phe Ser Tyr Ile Ala Lys Glu 5775 5780 tctgtacccc atctctgtct atggaaaaaa ctctgaaaca caaaataaaa taaagttcaa 33582 gtgttttatt gattcaacag ttttacagga ttcgagcagt tatttttcct ccaccctccc 33642 aggacatgga atacaccacc ctctcccccc gcacagcctt gaacatctga atgccattgg 33702 tgatggacat gcttttggtc tccacgttcc acacagtttc agagcgagcc agtctcgggt 33762 cggtcaggga gatgaaaccc tccgggcact cccgcatctg cacctcacag ctcaacagct 33822 gaggattgtc ctcggtggtc gggatcacgg tta tct gga aga agc aga aga 33873 Ser Gly Arg Ser Arg Arg 5785 gcg gcg gtg gga atc ata gtc cgc gaa cgg gat cgg ccg gtg gtg 33918 Ala Ala Val Gly Ile Ile Val Arg Glu Arg Asp Arg Pro Val Val 5790 5795 5800 tcg cat cag gcc ccg cag cag tcg ctg tcg ccg ccg ctc cgt caa 33963 Ser His Gln Ala Pro Gln Gln Ser Leu Ser Pro Pro Leu Arg Gln 5805 5810 5815 gct gct gct cag ggg gtc cgg gtc cag gga ctc cct cag cat gat 34008 Ala Ala Ala Gln Gly Val Arg Val Gln Gly Leu Pro Gln His Asp 5820 5825 5830 gcc cac ggc cct cag cat cag tcg tct ggt gcg gcg ggc gca gca 34053 Ala His Gly Pro Gln His Gln Ser Ser Gly Ala Ala Gly Ala Ala 5835 5840 5845 gcg cat gcg gat ctc gct cag gtc gct gca gta cgt gca aca cag 34098 Ala His Ala Asp Leu Ala Gln Val Ala Ala Val Arg Ala Thr Gln 5850 5855 5860 gac cac cag gtt gtt caa cag tcc ata gtt caa cac gct cca gcc 34143 Asp His Gln Val Val Gln Gln Ser Ile Val Gln His Ala Pro Ala 5865 5870 5875 gaa act cat cgc ggg aag gat gct acc cac gtg gcc gtc gta cca 34188 Glu Thr His Arg Gly Lys Asp Ala Thr His Val Ala Val Val Pro 5880 5885 5890 gat cct cag gta aat caa gtg gcg ccc cct cca gaa cac gct gcc 34233 Asp Pro Gln Val Asn Gln Val Ala Pro Pro Pro Glu His Ala Ala 5895 5900 5905 cat gta cat gat ctc ctt ggg cat gtg gcg gtt cac cac ctc ccg 34278 His Val His Asp Leu Leu Gly His Val Ala Val His His Leu Pro 5910 5915 5920 gta cca cat cac cct ctg gtt gaa cat gca gcc ccg gat gat cct 34323 Val Pro His His Pro Leu Val Glu His Ala Ala Pro Asp Asp Pro 5925 5930 5935 gcg gaa cca cag ggc cag cac cgc ccc gcc cgc cat gca gcg aag 34368 Ala Glu Pro Gln Gly Gln His Arg Pro Ala Arg His Ala Ala Lys 5940 5945 5950 aga ccc cgg gtc ccg aca atg gca atg gag gac cca ccg ctc gta 34413 Arg Pro Arg Val Pro Thr Met Ala Met Glu Asp Pro Pro Leu Val 5955 5960 5965 ccc gtg gat cat ctg gga gct gaa caa gtc tat gtt ggc aca gca 34458 Pro Val Asp His Leu Gly Ala Glu Gln Val Tyr Val Gly Thr Ala 5970 5975 5980 cag gca tat gct cat gca tct ctt cag cac tct cag ctc ctc ggg 34503 Gln Ala Tyr Ala His Ala Ser Leu Gln His Ser Gln Leu Leu Gly 5985 5990 5995 ggt caa aac cat atc cca ggg cac ggg gaa ctc ttg cag gac agc 34548 Gly Gln Asn His Ile Pro Gly His Gly Glu Leu Leu Gln Asp Ser 6000 6005 6010 gaa ccc cgc aga aca ggg caa tcc tcg cac ata act tac att gtg 34593 Glu Pro Arg Arg Thr Gly Gln Ser Ser His Ile Thr Tyr Ile Val 6015 6020 6025 cat gga cag ggt atc gca atc agg cag cac cgg gtg atc ctc cac 34638 His Gly Gln Gly Ile Ala Ile Arg Gln His Arg Val Ile Leu His 6030 6035 6040 cag aga agc gcg ggt ctc ggt ctc ctc aca gcg tgg taa ggg ggc 34683 Gln Arg Ser Ala Gly Leu Gly Leu Leu Thr Ala Trp Gly Gly 6045 6050 6055 cgg ccg ata cgg gtg atg gcg gga cgc ggc tga tcg tgt tcg cga 34728 Arg Pro Ile Arg Val Met Ala Gly Arg Gly Ser Cys Ser Arg 6060 6065 6070 ccg tgt cat gat gca gtt gct ttc gga cat tttcgtactt gctgtagcag 34778 Pro Cys His Asp Ala Val Ala Phe Gly His 6075 6080 aacctggtcc gggcgctgca caccgatcgc cggcggcggt cccggcgctt ggaacgctcg 34838 gtgttgaagt tgtaaaacag ccactctctc agaccgtgca gcagatctag ggcctcagga 34898 gtgatgaaga tcccatcatg cctgatggct ctaatcacat cgaccaccgt ggaatgggcc 34958 agacccagcc agatgatgca attttgttgg gtttcggtga cggcggggga gggaagaaca 35018 ggaagaacca tgattaactt ttaatccaaa cggtctcgga gcacttcaaa atgaagatcg 35078 cggagatggc acctctcgcc cccgctgtgt tggtggaaaa taacagccag gtcaaaggtg 35138 atacggttct cgagatgttc cacggtggct tccagcaaag cctccacgcg cacatccaga 35198 aacaagacaa tagcgaaagc gggagggttc tctaattcct caatcatcat gttacactcc 35258 tgcaccatcc ccagataatt ttcatttttc cagccttgaa tgattcgaac tagttcctga 35318 ggtaaatcca agccagccat gataaagagc tcgcgcagag cgccctccac cggcattctt 35378 aagcacaccc tcataattcc aagatattct gctcctggtt cacctgcagc agattgacaa 35438 gcggaatatc aaaatctctg ccgcgatccc taagctcctc cctcagcaat aactgtaagt 35498 actctttcat atcctctccg aaatttttag ccataggacc gccaggaatg agattaggac 35558 aagccacatt acagataaac cgaagtcccc cccagtgagc attgccaaat gtaagattga 35618 aataagcatg ctggctagac ccggtgatat cttccagata actggacaga aaatcgccca 35678 ggcaattttt aagaaaatca acaaaagaaa aatcttccag gtgcacgttt agggcctcgg 35738 gaacaacgat ggagtaagtg caaggggtgc gttccagcat ggttagttag ctgatctgta 35798 aaaaaacaaa aaataaaaca ttaaaccatg ctagcctggc gaacaggtgg gtaaatcgtt 35858 ctctccagca ccaggcaggc cacggggtct ccggcgcgac cctcgtaaaa attgtcgcta 35918 tgattgaaaa ccatcacaga gagacgttcc cggtggccgg cgtgaatgat tcgacaagat 35978 gaatacaccc ccggaacatt ggcgtccgcg agtgaaaaaa agcggccgag gaagcaataa 36038 ggcactacaa tgctcagtct caagtccagc aaagcgatgc catgcggatg aagcacaaaa 36098 ttctcaggtg cgtacaaaat gtaattactc ccctcctgca caggcagcaa agccccagat 36158 ccctccagat acacatacaa agcctcagcg tccatagctt accgagcagc agcacacaac 36218 aggcgcaaga gtcagagaaa ggctgagctc taacctgtcc cccgctctct gctcaatata 36278 tagcccagat ctacactgac gtaaaggcca aagtctaaaa atacccgcca aataatcaca 36338 cacgcccagc acacgcccag aaaccggtga cacactcaaa aaaatacgcg cacttcctca 36398 aacgcccaaa ctgccgtcat ttccgggttc ccacgctacg tcatcagaat tcgactttca 36458 aatccgtcga ccgttaaaca cgtcactcgc cccgccccta acggtcgccc tcctctcggc 36518 caatcacagc cccgcatccc caaattcaaa cgcctcattt gcatattaac gcgcacaaaa 36578 agtttgaggt atattattga tgatgatcgt ttaaactatg cggtgtgaaa taccgcacag 36638 atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct 36698 gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt 36758 atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc 36818 caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga 36878 gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata 36938 ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac 36998 cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg 37058 taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc 37118 cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag 37178 acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt 37238 aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt 37298 atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg 37358 atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac 37418 gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca 37478 gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac 37538 ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac 37598 ttggtctgac ag tta cca atg ctt aat cag tga ggc acc tat ctc agc 37646 Leu Pro Met Leu Asn Gln Gly Thr Tyr Leu Ser 6085 6090 gat ctg tct att tcg ttc atc cat agt tgc ctg act ccc cgt cgt 37691 Asp Leu Ser Ile Ser Phe Ile His Ser Cys Leu Thr Pro Arg Arg 6095 6100 6105 gta gat aac tac gat acg gga ggg ctt acc atc tgg ccc cag tgc 37736 Val Asp Asn Tyr Asp Thr Gly Gly Leu Thr Ile Trp Pro Gln Cys 6110 6115 6120 tgc aat gat acc gcg aga ccc acg ctc acc ggc tcc aga ttt atc 37781 Cys Asn Asp Thr Ala Arg Pro Thr Leu Thr Gly Ser Arg Phe Ile 6125 6130 6135 agc aat aaa cca gcc agc cgg aag ggc cga gcg cag aag tgg tcc 37826 Ser Asn Lys Pro Ala Ser Arg Lys Gly Arg Ala Gln Lys Trp Ser 6140 6145 6150 tgc aac ttt atc cgc ctc cat cca gtc tat taa ttg ttg ccg gga 37871 Cys Asn Phe Ile Arg Leu His Pro Val Tyr Leu Leu Pro Gly 6155 6160 6165 agc tag agt aag tag ttc gcc agt taa tag ttt gcg caa cgt tgt tgc 37919 Ser Ser Lys Phe Ala Ser Phe Ala Gln Arg Cys Cys 6170 6175 cat tgc tgc agg cat cgt ggt gtc acg ctc gtc gtt tgg tat ggc 37964 His Cys Cys Arg His Arg Gly Val Thr Leu Val Val Trp Tyr Gly 6180 6185 6190 ttc att cag ctc cgg ttc cca acg atc aag gcg agt tac atg atc 38009 Phe Ile Gln Leu Arg Phe Pro Thr Ile Lys Ala Ser Tyr Met Ile 6195 6200 6205 ccc cat gtt gtg caa aaa agc ggt tag ctc ctt cgg tcc tcc gat 38054 Pro His Val Val Gln Lys Ser Gly Leu Leu Arg Ser Ser Asp 6210 6215 6220 cgt tgt cag aag taa gtt ggc cgc agt gtt atc act cat ggt tat 38099 Arg Cys Gln Lys Val Gly Arg Ser Val Ile Thr His Gly Tyr 6225 6230 6235 ggc agc act gca taa ttc tct tac tgt cat gcc atc cgt aag atg 38144 Gly Ser Thr Ala Phe Ser Tyr Cys His Ala Ile Arg Lys Met 6240 6245 6250 ctt ttc tgt gac tgg tga gta ctc aac caa gtc att ctg aga ata 38189 Leu Phe Cys Asp Trp Val Leu Asn Gln Val Ile Leu Arg Ile 6255 6260 6265 gtg tat gcg gcg acc gag ttg ctc ttg ccc ggc gtc aac acg gga 38234 Val Tyr Ala Ala Thr Glu Leu Leu Leu Pro Gly Val Asn Thr Gly 6270 6275 6280 taa tac cgc gcc aca tag cag aac ttt aaa agt gct cat cat tgg aaa 38282 Tyr Arg Ala Thr Gln Asn Phe Lys Ser Ala His His Trp Lys 6285 6290 acg ttc ttc ggg gcg aaa act ctc aag gat ctt acc gct gtt gag 38327 Thr Phe Phe Gly Ala Lys Thr Leu Lys Asp Leu Thr Ala Val Glu 6295 6300 6305 atc cag ttc gat gta acc cac tcg tgc acc caa ctg atc ttc agc 38372 Ile Gln Phe Asp Val Thr His Ser Cys Thr Gln Leu Ile Phe Ser 6310 6315 6320 atc ttt tac ttt cac cag cgt ttc tgg gtg agc aaa aac agg aag 38417 Ile Phe Tyr Phe His Gln Arg Phe Trp Val Ser Lys Asn Arg Lys 6325 6330 6335 gca aaa tgc cgc aaa aaa ggg aat aag ggc gac acg gaa atg ttg 38462 Ala Lys Cys Arg Lys Lys Gly Asn Lys Gly Asp Thr Glu Met Leu 6340 6345 6350 aat act cat act cttccttttt caatattatt gaagcattta tcagggttat 38514 Asn Thr His Thr 6355 tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg 38574 cgcacatttc cccgaaaagt gccacctgac gtctaagaaa ccattattat catgacatta 38634 acctataaaa ataggcgtat cacgaggccc tttcgtcttc aagaattgtt taaactac 38692 <210> 247 <211> 363 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 247 Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 1 5 10 15 Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 20 25 30 His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 35 40 45 Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 50 55 60 Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 65 70 75 80 Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 85 90 95 Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 100 105 110 Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val 115 120 125 Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 130 135 140 Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 145 150 155 160 Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 165 170 175 Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 180 185 190 Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 195 200 205 Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 210 215 220 Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 225 230 235 240 Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 245 250 255 Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 260 265 270 Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 275 280 285 Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 290 295 300 Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 305 310 315 320 Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 325 330 335 Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 340 345 350 Val Gly Gly Pro Gly His Lys Ala Arg Val Leu 355 360 <210> 248 <211> 587 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 248 Met Gln Gln Gln Pro Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu 1 5 10 15 Gln Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala 20 25 30 Met Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg 35 40 45 Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val 50 55 60 Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn 65 70 75 80 Ala Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val 85 90 95 Tyr Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val 100 105 110 Gln Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ser 115 120 125 Gln Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala 130 135 140 Leu Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln 145 150 155 160 Glu Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Ala Glu 165 170 175 Val Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln 180 185 190 Thr Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys 195 200 205 Asn Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala 210 215 220 Thr Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu 225 230 235 240 Val Ala Pro Phe Thr Asp Ser Gly Ser Val Ser Arg Asp Ser Tyr Leu 245 250 255 Gly Tyr Leu Leu Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val 260 265 270 Asp Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly 275 280 285 Gln Glu Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr 290 295 300 Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu 305 310 315 320 Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met 325 330 335 Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn 340 345 350 Met Glu Pro Ser Met Tyr Ala Arg Asn Arg Pro Phe Ile Asn Lys Leu 355 360 365 Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr 370 375 380 Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr 385 390 395 400 Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp 405 410 415 Val Asp Ser Ser Val Phe Ser Pro Arg Pro Thr Thr Thr Val Trp Lys 420 425 430 Lys Glu Gly Gly Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly Arg Ala 435 440 445 Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu 450 455 460 Pro Phe Ser Leu Asn Ser Val Arg Ser Ser Glu Leu Gly Arg Leu Thr 465 470 475 480 Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu 485 490 495 Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu 500 505 510 Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala His Glu His Arg Asp 515 520 525 Glu Pro Arg Ala Ser Ser Ser Ala Gly Ala Thr Arg Arg Arg Gln Arg 530 535 540 His Asp Arg Gln Arg Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp 545 550 555 560 Asp Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe 565 570 575 Ala His Leu Arg Pro Arg Ile Gly Arg Leu Met 580 585 <210> 249 <211> 542 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 249 Met Met Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Val Ala Ala Ala Met Gln Pro Pro Leu Glu Ala 20 25 30 Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg Asn Ser 35 40 45 Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg Leu Tyr 50 55 60 Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr Gln Asn 65 70 75 80 Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp Phe Thr 85 90 95 Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg 100 105 110 Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro Asn Val 115 120 125 Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser 130 135 140 Arg Lys Thr Pro Asn Gly Val Thr Val Asp Glu Asn Tyr Asp Gly Ser 145 150 155 160 Gln Asp Glu Leu Thr Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly 165 170 175 Asn Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile 180 185 190 Asp Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp 195 200 205 Ile Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro 210 215 220 Val Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His 225 230 235 240 Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser 245 250 255 Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu 260 265 270 Gly Phe Gln Ile Leu Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala 275 280 285 Leu Leu Asp Val Glu Ala Tyr Glu Lys Ser Lys Glu Glu Ala Ala Ala 290 295 300 Ala Ala Thr Ala Ala Val Ala Thr Ala Ala Thr Thr Asp Ala Asp Ala 305 310 315 320 Ala Thr Thr Thr Arg Gly Asp Thr Phe Ala Thr Gln Ala Glu Glu Ala 325 330 335 Ala Ala Leu Ala Ala Thr Asp Asp Ser Glu Ser Lys Ile Val Ile Lys 340 345 350 Pro Val Glu Lys Asp Ser Lys Asp Arg Ser Tyr Asn Val Leu Ser Asp 355 360 365 Gly Lys Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly 370 375 380 Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp 385 390 395 400 Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met 405 410 415 Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn Tyr Pro 420 425 430 Val Val Gly Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser Phe Phe Asn 435 440 445 Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Ala Phe Thr Ser Leu Thr 450 455 460 His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Val Arg Pro Pro 465 470 475 480 Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp 485 490 495 His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val 500 505 510 Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala 515 520 525 Leu Gly Val Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 530 535 540 <210> 250 <211> 194 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 250 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Ala Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ser 130 135 140 Ser Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala 145 150 155 160 Ala Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val 165 170 175 Arg Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro 180 185 190 Arg Thr <210> 251 <211> 348 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 251 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys Glu Glu Arg Lys Pro Arg 20 25 30 Lys Leu Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Glu Asp Asp Gly 35 40 45 Leu Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp 50 55 60 Arg Gly Arg Lys Val Lys Pro Val Leu Arg Pro Gly Thr Thr Val Val 65 70 75 80 Phe Thr Pro Gly Glu Arg Ser Gly Ser Ala Ser Lys Arg Ser Tyr Asp 85 90 95 Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu 100 105 110 Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Pro Ala Pro Leu Lys Glu 115 120 125 Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu 130 135 140 Lys Pro Val Thr Leu Gln Gln Val Leu Pro Ser Ala Ala Pro Arg Arg 145 150 155 160 Gly Phe Lys Arg Glu Gly Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu 165 170 175 Met Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu His Met Lys 180 185 190 Val Asp Pro Glu Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln 195 200 205 Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr 210 215 220 Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr 225 230 235 240 Met Glu Val Gln Thr Asp Pro Trp Met Pro Ala Pro Ala Ser Thr Thr 245 250 255 Thr Thr Thr Arg Arg Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met 260 265 270 Pro Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg 275 280 285 Gly Thr Arg Phe Tyr Arg Gly Tyr Ser Ser Arg Arg Lys Thr Thr Thr 290 295 300 Arg Arg Arg Arg Arg Arg Thr Arg Arg Ser Thr Thr Ala Thr Ser Ala 305 310 315 320 Ala Ala Leu Val Arg Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu Thr 325 330 335 Leu Pro Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 340 345 <210> 252 <211> 77 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 252 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly Asn Gly Leu Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 253 <211> 244 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 253 Met Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg 1 5 10 15 Pro Phe Met Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly 20 25 30 Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly 35 40 45 Ser Thr Leu Lys Thr Tyr Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly 50 55 60 Gln Ala Leu Arg Asp Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val 65 70 75 80 Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn 85 90 95 Gln Ala Val Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro 100 105 110 Ala Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu 115 120 125 Asp Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu 130 135 140 Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu 145 150 155 160 Gly Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu 165 170 175 Lys Pro Glu Ser Asn Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Gln 180 185 190 Pro Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val 195 200 205 Ala Arg Ala Arg Pro Gly Gly Ser Ala Arg Pro His Ala Asn Trp Gln 210 215 220 Ser Thr Leu Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg 225 230 235 240 Arg Arg Cys Tyr <210> 254 <211> 943 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 254 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Ser Ser Gln Trp Glu Arg Ala Lys Thr Asn Asn Asn Gly 130 135 140 Ala Thr Glu Ser Val Thr Phe Gly Val Ala Ala Met Gly Gly Ile Asp 145 150 155 160 Ile Thr Lys Glu Gly Leu Gln Ile Gly Thr Asp Glu Thr Lys Ala Asp 165 170 175 Ser Lys Glu Ile Tyr Ala Asp Lys Thr Tyr Gln Pro Glu Pro Gln Ile 180 185 190 Gly Glu Glu Asn Trp Gln Glu Thr Phe Ser Tyr Tyr Gly Gly Arg Ala 195 200 205 Leu Lys Lys Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys 210 215 220 Pro Thr Asn Val Lys Gly Gly Gln Ala Lys Phe Lys Val Gln Asp Gly 225 230 235 240 Gln Gln Thr Thr Glu Tyr Asp Ile Asp Leu Ala Phe Phe Asp Ile Pro 245 250 255 Asn Ser Gly Thr Gly Gly Asn Gly Thr Asn Val Asn Tyr Asp Pro Asp 260 265 270 Met Val Met Tyr Thr Glu Asn Val Asp Leu Glu Thr Pro Asp Thr His 275 280 285 Ile Val Tyr Lys Pro Gly Thr Ser Asp Asp Ser Ser Glu Ala Asn Leu 290 295 300 Leu Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp 305 310 315 320 Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val 325 330 335 Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp 340 345 350 Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp 355 360 365 Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp 370 375 380 Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro 385 390 395 400 Asn Tyr Cys Phe Pro Leu Asp Gly Ala Gly Thr Asn Ala Val Tyr Gln 405 410 415 Gly Val Lys Ala Lys Thr Asn Gly Gly Ala Ala Asn Gly Asp Trp Glu 420 425 430 Gln Asp Thr Asp Val Ser Asn Ile Asn Gln Ile Cys Lys Gly Asn Ile 435 440 445 Tyr Ala Met Glu Ile Asn Leu Gln Ala Asn Leu Trp Arg Ser Phe Leu 450 455 460 Tyr Ser Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr Pro 465 470 475 480 Ala Asn Ile Thr Leu Pro Thr Asn Thr Asn Thr Tyr Asp Tyr Met Asn 485 490 495 Gly Arg Val Ala Pro Pro Ser Leu Val Asp Ala Tyr Ile Asn Ile Gly 500 505 510 Ala Arg Trp Ser Leu Asp Pro Met Asp Asn Val Asn Pro Phe Asn His 515 520 525 His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly 530 535 540 Arg Phe Val Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile 545 550 555 560 Lys Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe 565 570 575 Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu 580 585 590 Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala 595 600 605 Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met 610 615 620 Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala 625 630 635 640 Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Val Pro Ile 645 650 655 Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr 660 665 670 Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro 675 680 685 Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr 690 695 700 Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe Asp Ser Ser Val 705 710 715 720 Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile 725 730 735 Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met 740 745 750 Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly 755 760 765 Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser 770 775 780 Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Val 785 790 795 800 Asn Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn Asn 805 810 815 Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln Pro 820 825 830 Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val Thr 835 840 845 Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met Trp Arg Ile 850 855 860 Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly 865 870 875 880 Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Asn Phe 885 890 895 Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr Val Val Phe Glu 900 905 910 Val Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu 915 920 925 Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 930 935 940 <210> 255 <211> 208 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 255 Met Ala Glu Pro Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile 1 5 10 15 Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg 20 25 30 Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn 35 40 45 Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp 50 55 60 Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser 65 70 75 80 Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu Leu 85 90 95 Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu Lys 100 105 110 Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu Phe 115 120 125 Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro Met 130 135 140 Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly Met 145 150 155 160 Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu Ala 165 170 175 Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe Arg Ser His Arg 180 185 190 Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Gln Asp Met 195 200 205 <210> 256 <211> 503 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 256 Glu Ile Glu Gly Val Leu Pro Ala Leu Gly Val Pro Arg Gly Gln Gly 1 5 10 15 Tyr Val Ala Glu Leu Val Leu Gly Gln Pro Leu Glu Leu Gly Asp Gln 20 25 30 Gln Leu Arg His Gly Glu Val Gly Glu Arg Val Ala Pro Gln Leu Ala 35 40 45 Arg Glu Leu Gln Gly Ala Gln Gln Val Gly Arg Gly Asp Leu Glu Ile 50 55 60 Ala Val Gly Thr Arg Val Leu Arg Ala Arg Val Ala Val His Gly Val 65 70 75 80 Ala Ala Leu Glu His His Gln Gly Arg Val Leu His Ala Arg Gln His 85 90 95 Arg Arg Val Gly Asp Ala Leu His Val Gln Ile Leu Gly Val Gly His 100 105 110 Pro Glu Gly Gly His Leu Ala Gly Leu Pro Pro His Ala Gly His Ala 115 120 125 Ala Gly Leu Val Val Ala Ile Ala Val Gln Gly Asp Gln His His Leu 130 135 140 Gly Leu Leu Gly Ala His Ala Arg Val His Gly Leu His Glu Ser Leu 145 150 155 160 Gln Leu Ala Glu Gly Leu Leu Arg Leu Ala Ala Leu Gly Glu Glu Asp 165 170 175 Pro Ala Gly Leu Ala Arg Glu Leu Val Gly Ser Ala Ala Arg Val Val 180 185 190 His Ala Ala Ala Arg Val Val Val Gly Gln Leu His His Ala Ala Pro 195 200 205 Pro Ala Val Leu Gly Asp Leu Gly Pro Val Gly Val Leu Leu Gln Arg 210 215 220 Ala Leu Pro Val Leu Ala Arg His Ile His Leu Asp Arg Val Leu Leu 225 230 235 240 Leu Asp His His Gly Pro Val Gln Ala Pro Gln Leu Ala Leu Gly Leu 245 250 255 Gly Ala Ala Val Gln Pro Gln Arg Ala Ala Gly Ala Leu Pro Val Leu 260 265 270 Val Gly Asp Leu Gly Val Arg Val His Glu Ala Leu Gln Glu Ala Ala 275 280 285 His His Arg Gly Gln Gly Leu Val Ala Gly Glu Gly Gln Arg Asp Ala 290 295 300 Ala Val Leu Leu Val His Ile Gln Val Ala Asp Ala Ala Val His Leu 305 310 315 320 Ala Leu Leu Gly His Gln Leu Glu Gly Gly Leu Gln Val Ala Leu His 325 330 335 Ala Val Pro Val His Gln Gln Arg His His Phe His Ala Leu Leu Pro 340 345 350 Gly Arg Asn Asp Arg Gln Ala Gln Gly Val Leu His Arg His Leu Ser 355 360 365 Arg Arg Arg Arg Ser Gln Gly Val Val Leu Val Gln Gly Leu Lys His 370 375 380 Ser Leu Ala Val Leu Leu Gly Asp Ala His Gly Gly Glu Gly Glu Ala 385 390 395 400 His Gly Arg Gln Leu Leu Leu Gly Leu Pro Phe Val Leu Ala Val Leu 405 410 415 Ala Asp Val Leu Gln Arg His Met Leu Gly Leu Ala Gly Phe Leu Phe 420 425 430 Gly Arg Gln Arg Arg Arg Arg Arg Arg Arg Ala Gly Arg Ala Arg Val 435 440 445 Leu Ala His His Asp Tyr Phe Phe Phe Leu Ala Val Val Arg Asp His 450 455 460 Ala Ala Val Gly Met Pro Leu Leu Gly Gln Arg Arg Arg Arg Arg Ala 465 470 475 480 Leu Ala Val Arg Arg Ala Ala Gly Arg Ala Pro Ser Ala Phe Gly Gly 485 490 495 Ala Leu Leu Ala Ala Leu Leu 500 <210> 257 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 257 Leu Thr Ser Ser Ala Ala Gly His 1 5 <210> 258 <211> 185 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 258 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Leu Pro 1 5 10 15 Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu 20 25 30 Glu Met Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln 35 40 45 Asp Ser Leu Glu Asp Glu Val Glu Glu Ala Glu Glu Glu Ala Ala Ala 50 55 60 Ala Arg Pro Ser Ser Ser Ala Glu Lys Ala Ser Ser Thr Asp Thr Ile 65 70 75 80 Ser Ala Pro Gly Arg Gly Leu Gly Gly Arg Ala His Ser Arg Trp Asp 85 90 95 Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys Glu 100 105 110 Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser 115 120 125 Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu 130 135 140 Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr 145 150 155 160 Arg His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu Ala Glu Thr 165 170 175 Gln Gln Gln Gln Lys Thr Ser Ser Ser 180 185 <210> 259 <211> 227 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 259 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr 50 55 60 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 260 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 260 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Ala 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Ile Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Arg Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asn His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 261 <211> 176 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 261 Met Gly Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val Val 1 5 10 15 Leu Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu Lys Ala 20 25 30 Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Thr Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Ala His Met Cys Asp Thr Val Met Trp Met Ser Lys Gln Tyr Asp Met 115 120 125 Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Leu Cys Thr Val Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 262 <211> 200 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 262 Met Ala Ser Val Lys Phe Leu Leu Leu Phe Ala Ser Leu Ile Thr Val 1 5 10 15 Ile Ser Asn Glu Lys Leu Thr Ile Tyr Ile Gly Thr Asn His Thr Leu 20 25 30 Glu Gly Ile Pro Lys Ser Ser Trp Tyr Cys Tyr Phe Asp Gln Asp Pro 35 40 45 Asp Leu Thr Ile Glu Leu Cys Gly Asn Lys Gly Gln Asn Thr Ser Ile 50 55 60 His Leu Ile Asn Phe Lys Cys Gly Asp Asp Leu Lys Leu Ile Asn Ile 65 70 75 80 Thr Lys Glu Tyr Gly Gly Met Tyr Tyr Tyr Val Thr Glu Asn Asn Asn 85 90 95 Met Gln Phe Tyr Glu Val Thr Val Thr Asn Pro Thr Thr Pro Arg Thr 100 105 110 Thr Thr Thr Thr Thr Lys Thr Thr Pro Val Thr Thr Met Gln Leu Thr 115 120 125 Thr Asn Asn Ile Phe Ala Met Arg Gln Lys Ala Asn Asn Ser Thr Ser 130 135 140 Ile Gln Pro Pro Pro Pro Ser Glu Glu Ile Pro Lys Ser Met Ile Gly 145 150 155 160 Ile Ile Val Ala Val Val Val Cys Met Leu Ile Ile Ala Leu Cys Met 165 170 175 Val Tyr Tyr Ala Phe Cys Tyr Arg Lys His Arg Leu Asn Asp Lys Leu 180 185 190 Glu His Leu Leu Ser Val Glu Phe 195 200 <210> 263 <211> 292 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 263 Met Lys Ala Val Ser Ala Leu Val Phe Cys Ser Leu Ile Gly Thr Val 1 5 10 15 Phe Ser Val Ser Phe Leu Lys Gln Ile Asn Val Thr Glu Gly Glu Asn 20 25 30 Val Thr Leu Val Gly Val Glu Gly Ala Gln Asn Thr Thr Trp Thr Lys 35 40 45 Tyr His Leu Asp Gly Trp Lys Asp Ile Cys Asn Trp Ser Val Ile Thr 50 55 60 Tyr Thr Cys Glu Gly Val Asn Leu Thr Ile Val Asn Ala Ser Gln Asn 65 70 75 80 Gln Lys Gly Trp Ile Lys Gly Gln Ser Val Ser Val Thr Ser Glu Gly 85 90 95 Tyr Tyr Thr Gln His Thr Leu Ile Tyr Asp Ile Ile Val Ile Pro Leu 100 105 110 Pro Thr Pro Ser Pro Pro Ser Thr Thr Thr Gln Thr Thr His Thr Thr 115 120 125 Gln Thr Thr Thr Tyr Ser Thr Ser Asn Gln Pro Thr Thr Thr Thr Thr 130 135 140 Ala Glu Val Ala Ser Ser Ser Gly Val Arg Ala Ala Phe Leu Met Leu 145 150 155 160 Ala Pro Ser Ser Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Glu 165 170 175 Phe Leu Ser Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe 180 185 190 Ser Ser Thr Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro 195 200 205 Ala Thr Thr Thr Thr Pro Ala Ile Leu Pro Thr Pro Leu Lys Gln Thr 210 215 220 Glu Asp Ser Gly Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly 225 230 235 240 Leu Val Ile Leu Ala Val Leu Leu Tyr Tyr Ile Phe Arg Arg Arg Ile 245 250 255 Pro Asn Ala His Arg Lys Pro Val Tyr Lys Pro Ile Ile Val Gly Gln 260 265 270 Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser 275 280 285 Phe Thr Val Trp 290 <210> 264 <211> 135 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 264 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu Leu Leu Asp 1 5 10 15 Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg 20 25 30 Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Gly Ile Ala Ile 35 40 45 His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile 50 55 60 Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser Tyr Glu Leu Leu 65 70 75 80 Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val 85 90 95 Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys 100 105 110 Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu 115 120 125 Arg Asp Leu Leu Pro Met Asn 130 135 <210> 265 <211> 445 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 265 Met Ser Lys Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro Val Tyr 1 5 10 15 Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro 20 25 30 Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser 35 40 45 Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu 50 55 60 Lys Leu Gly Asp Gly Val Asp Leu Asp Ser Ser Gly Lys Leu Ile Ser 65 70 75 80 Asn Thr Ala Thr Lys Ala Ala Ala Pro Leu Ser Phe Ser Asn Asn Thr 85 90 95 Ile Ser Leu Asn Met Asp Thr Pro Phe Tyr Asn Asn Asn Gly Lys Leu 100 105 110 Gly Met Lys Val Thr Ala Pro Leu Lys Ile Leu Asp Thr Asp Leu Leu 115 120 125 Lys Thr Leu Val Val Ala Tyr Gly Gln Gly Leu Gly Thr Asn Thr Thr 130 135 140 Gly Ala Leu Val Ala Gln Leu Ala Ser Pro Leu Ala Phe Asp Ser Asn 145 150 155 160 Ser Lys Ile Ala Leu Asn Leu Gly Asn Gly Pro Leu Lys Val Asp Ala 165 170 175 Asn Arg Leu Asn Ile Asn Cys Asn Arg Gly Leu Tyr Val Thr Thr Thr 180 185 190 Lys Asp Ala Leu Glu Ala Asn Ile Ser Trp Ala Asn Ala Met Thr Phe 195 200 205 Ile Gly Asn Ala Met Gly Val Asn Ile Asp Thr Gln Lys Gly Leu Gln 210 215 220 Phe Gly Thr Thr Ser Thr Val Ala Asp Val Lys Asn Ala Tyr Pro Ile 225 230 235 240 Gln Ile Lys Leu Gly Ala Gly Leu Thr Phe Asp Ser Thr Gly Ala Ile 245 250 255 Val Ala Trp Asn Lys Asp Asp Asp Lys Leu Thr Leu Trp Thr Thr Ala 260 265 270 Asp Pro Ser Pro Asn Cys His Ile Tyr Ser Glu Lys Asp Ala Lys Leu 275 280 285 Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Ser 290 295 300 Leu Ile Ala Val Asp Thr Gly Ser Leu Asn Pro Ile Thr Gly Thr Val 305 310 315 320 Thr Thr Ala Leu Val Ser Leu Lys Phe Asp Ala Asn Gly Val Leu Gln 325 330 335 Ser Ser Ser Thr Leu Asp Ser Asp Tyr Trp Asn Phe Arg Gln Gly Asp 340 345 350 Val Thr Pro Ala Glu Ala Tyr Thr Asn Ala Ile Gly Phe Met Pro Asn 355 360 365 Leu Lys Ala Tyr Pro Lys Asn Thr Ser Gly Ala Ala Lys Ser His Ile 370 375 380 Val Gly Lys Val Tyr Leu His Gly Asp Thr Asp Lys Pro Leu Asp Leu 385 390 395 400 Ile Ile Thr Phe Asn Glu Thr Ser Asp Glu Ser Cys Thr Tyr Cys Ile 405 410 415 Asn Phe Gln Trp Gln Trp Gly Ala Asp Gln Tyr Lys Asn Glu Thr Leu 420 425 430 Ala Val Ser Ser Phe Thr Phe Ser Tyr Ile Ala Lys Glu 435 440 445 <210> 266 <211> 273 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 266 Ser Gly Arg Ser Arg Arg Ala Ala Val Gly Ile Ile Val Arg Glu Arg 1 5 10 15 Asp Arg Pro Val Val Ser His Gln Ala Pro Gln Gln Ser Leu Ser Pro 20 25 30 Pro Leu Arg Gln Ala Ala Ala Gln Gly Val Arg Val Gln Gly Leu Pro 35 40 45 Gln His Asp Ala His Gly Pro Gln His Gln Ser Ser Gly Ala Ala Gly 50 55 60 Ala Ala Ala His Ala Asp Leu Ala Gln Val Ala Ala Val Arg Ala Thr 65 70 75 80 Gln Asp His Gln Val Val Gln Gln Ser Ile Val Gln His Ala Pro Ala 85 90 95 Glu Thr His Arg Gly Lys Asp Ala Thr His Val Ala Val Val Pro Asp 100 105 110 Pro Gln Val Asn Gln Val Ala Pro Pro Pro Glu His Ala Ala His Val 115 120 125 His Asp Leu Leu Gly His Val Ala Val His His Leu Pro Val Pro His 130 135 140 His Pro Leu Val Glu His Ala Ala Pro Asp Asp Pro Ala Glu Pro Gln 145 150 155 160 Gly Gln His Arg Pro Ala Arg His Ala Ala Lys Arg Pro Arg Val Pro 165 170 175 Thr Met Ala Met Glu Asp Pro Pro Leu Val Pro Val Asp His Leu Gly 180 185 190 Ala Glu Gln Val Tyr Val Gly Thr Ala Gln Ala Tyr Ala His Ala Ser 195 200 205 Leu Gln His Ser Gln Leu Leu Gly Gly Gln Asn His Ile Pro Gly His 210 215 220 Gly Glu Leu Leu Gln Asp Ser Glu Pro Arg Arg Thr Gly Gln Ser Ser 225 230 235 240 His Ile Thr Tyr Ile Val His Gly Gln Gly Ile Ala Ile Arg Gln His 245 250 255 Arg Val Ile Leu His Gln Arg Ser Ala Gly Leu Gly Leu Leu Thr Ala 260 265 270 Trp <210> 267 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 267 Gly Gly Arg Pro Ile Arg Val Met Ala Gly Arg Gly 1 5 10 <210> 268 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 268 Ser Cys Ser Arg Pro Cys His Asp Ala Val Ala Phe Gly His 1 5 10 <210> 269 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 269 Leu Pro Met Leu Asn Gln 1 5 <210> 270 <211> 75 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 270 Gly Thr Tyr Leu Ser Asp Leu Ser Ile Ser Phe Ile His Ser Cys Leu 1 5 10 15 Thr Pro Arg Arg Val Asp Asn Tyr Asp Thr Gly Gly Leu Thr Ile Trp 20 25 30 Pro Gln Cys Cys Asn Asp Thr Ala Arg Pro Thr Leu Thr Gly Ser Arg 35 40 45 Phe Ile Ser Asn Lys Pro Ala Ser Arg Lys Gly Arg Ala Gln Lys Trp 50 55 60 Ser Cys Asn Phe Ile Arg Leu His Pro Val Tyr 65 70 75 <210> 271 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 271 Leu Leu Pro Gly Ser 1 5 <210> 272 <211> 44 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 272 Phe Ala Gln Arg Cys Cys His Cys Cys Arg His Arg Gly Val Thr Leu 1 5 10 15 Val Val Trp Tyr Gly Phe Ile Gln Leu Arg Phe Pro Thr Ile Lys Ala 20 25 30 Ser Tyr Met Ile Pro His Val Val Gln Lys Ser Gly 35 40 <210> 273 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 273 Leu Leu Arg Ser Ser Asp Arg Cys Gln Lys 1 5 10 <210> 274 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 274 Val Gly Arg Ser Val Ile Thr His Gly Tyr Gly Ser Thr Ala 1 5 10 <210> 275 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 275 Phe Ser Tyr Cys His Ala Ile Arg Lys Met Leu Phe Cys Asp Trp 1 5 10 15 <210> 276 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 276 Val Leu Asn Gln Val Ile Leu Arg Ile Val Tyr Ala Ala Thr Glu Leu 1 5 10 15 Leu Leu Pro Gly Val Asn Thr Gly 20 <210> 277 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 277 Tyr Arg Ala Thr 1 <210> 278 <211> 74 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 278 Gln Asn Phe Lys Ser Ala His His Trp Lys Thr Phe Phe Gly Ala Lys 1 5 10 15 Thr Leu Lys Asp Leu Thr Ala Val Glu Ile Gln Phe Asp Val Thr His 20 25 30 Ser Cys Thr Gln Leu Ile Phe Ser Ile Phe Tyr Phe His Gln Arg Phe 35 40 45 Trp Val Ser Lys Asn Arg Lys Ala Lys Cys Arg Lys Lys Gly Asn Lys 50 55 60 Gly Asp Thr Glu Met Leu Asn Thr His Thr 65 70 <210> 279 <211> 38692 <212> DNA <213> Artificial Sequence <220> <223> p2876 - E1 deleted molecular clone with HIVgagshort insertion, based on Simian Adenovirus A1320 <220> <221> CDS <222> (23499)..(25892) <223> 100K <220> <221> CDS <222> (27476)..(28096) <223> E3 CR1-alpha <220> <221> CDS <222> (29257)..(29868) <223> E3 CR1-gamma <220> <221> CDS <222> (31053)..(31481) <223> E3 RID-beta <220> <221> CDS <222> (34667)..(35029) <223> E4\orf4 <400> 279 catcatcaat aatatacctc aaactttttg tgcgcgttaa tatgcaaatg aggcgtttga 60 atttggggat gcggggcggt gattggctgt gggaaaggcg accgttaggg gcggggcggg 120 tgacgttttg atgacgtgtt tgtgaggcgg agccggtttg caagttctcg tgggaaaagt 180 gacgtcaaac gaggtgtggt ttgaacacgg aaatactcaa ttttcccgcg ctctctgaca 240 ggaaatgagg tgtttctggg cggatgcaag tgaaaacggg ccattttcgc gcgaaaactg 300 aatgaggaag tgaaaatctg agtaatttcg cgtttatggc agggaggagt atttgccgag 360 ggccgagtag actttgaccg attacgtggg ggtttcgatt accgtgtttt tcacctaaat 420 ttccgcgtac ggtgtcaaag tccggtgttt ttacatcatt tccccgaaaa gtgccacctg 480 acgtaactat aacggtccta aggtagcgaa agctcagatc tcccgatccc ctatggtgca 540 ctctcagtac aatctgctct gatgccgcat agttaagcca gtatctgctc cctgcttgtg 600 tgttggaggt cgctgagtag tgcgcgagca aaatttaagc tacaacaagg caaggcttga 660 ccgacaattg catgaagaat ctgcttaggg ttaggcgttt tgcgctgctt cgcgatgtac 720 gggccagata tacgcgttga cattgattat tgactagtta ttaatagtaa tcaattacgg 780 ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc 840 cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca 900 tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg 960 cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg 1020 acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt 1080 ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca 1140 tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg 1200 tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact 1260 ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag 1320 ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata 1380 gaagacaccg ggaccgatcc agcctccgcg ggcgcgcgtc gacagagaga tgggtgcgag 1440 agcgtcagta ttaagcgggg gagaattaga tcgatgggaa aaaattcggt taaggccagg 1500 gggaaagaag aagtacaagc taaagcacat cgtatgggca agcagggagc tagaacgatt 1560 cgcagttaat cctggcctgt tagaaacatc agaaggctgt agacaaatac tgggacagct 1620 acaaccatcc cttcagacag gatcagagga gcttcgatca ctatacaaca cagtagcaac 1680 cctctattgt gtgcaccagc ggatcgagat caaggacacc aaggaagctt tagacaagat 1740 agaggaagag caaaacaagt ccaagaagaa ggcccagcag gcagcagctg acacaggaca 1800 cagcaatcag gtcagccaaa attaccctat agtgcagaac atccaggggc aaatggtaca 1860 tcaggccata tcacctagaa ctttaaatgc atgggtaaaa gtagtagaag agaaggcttt 1920 cagcccagaa gtgataccca tgttttcagc attatcagaa ggagccaccc cacaggacct 1980 gaacacgatg ttgaacaccg tggggggaca tcaagcagcc atgcaaatgt taaaagagac 2040 catcaatgag gaagctgcag aatgggatag agtgcatcca gtgcatgcag ggcctattgc 2100 accaggccag atgagagaac caaggggaag tgacatagca ggaactacta gtacccttca 2160 ggaacaaata ggatggatga caaataatcc acctatccca gtaggagaga tctacaagag 2220 gtggataatc ctgggattga acaagatcgt gaggatgtat agccctacca gcattctgga 2280 cataagacaa ggaccaaaag aaccctttag agactatgta gaccggttct ataaaactct 2340 aagagctgag caagcttcac aggaggtaaa aaattggatg acagaaacct tgttggtcca 2400 aaatgcgaac ccagattgta agaccatcct gaaggctctc ggcccagcgg ctacactaga 2460 agaaatgatg acagcatgtc agggagtagg aggacccggc cataaggcaa gagttttgta 2520 gggatccact agttctagac tcgagggggg gcccggtacc tttaagacca atgacttaca 2580 aggcagctgt agatcttagc cactttttaa aagaaaaggg gggactggaa gggctaattc 2640 actcccaaag aagacaagat aaaccgctga tcagcctcga ctgtgccttc tagttgccag 2700 ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact 2760 gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt 2820 ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat 2880 gctggggatg cggtgggctc tatggcttct gaggcggaaa gaaccagcag atctgcagat 2940 ctgaattcat ctatgtcggg tgcggagaaa gaggtaatga aatggcatta tgggtattat 3000 gggtctgcat taatgaatcg gccagattat gctggccacc gtgcatgtgg cctcgcaccc 3060 ccgcaagaca tggcccgagt tcgagcacaa cgtcatgacc cgctgcaatg tgcacctggg 3120 ctcccgccga ggcatgttca tgccatacca gtgcaacatg caatttgtga aggtgctgct 3180 ggagcccgat gccatgtcca gagtgagcct gacgggggtg tttgacatga atgtggagct 3240 gtggaaaatt ctgagatatg atgaatccaa gaccaggtgc cgggcctgcg aatgcggagg 3300 caagcacgcc aggcttcagc ccgtgtgtgt ggaggtgacg gaggacctgc gacccgatca 3360 tttggtgttg tcctgcaacg ggacggagtt cggctccagc ggggaagaat ctgactagag 3420 tgagtagtgt ttgggggtgg gtgggagcct gcatgatggg cagaatgact aaaatctgtg 3480 tttttctgcg cagcagcatg agcggaagcg cctcctttga gggaggggta ttcagccctt 3540 atctgacggg gcgtctcccc tcctgggctg gagtgcgtca gaatgtgatg ggatccacgg 3600 tggacggccg gcccgtgcag cccgcgaact cttcaaccct gacctacgcg accctgagct 3660 cctcgtccgt ggacgcagct gccgccgcag ctgctgcttc cgccgccagc gccgtgcgcg 3720 gaatggccct gggtgccggc tactacagct ctctggtggc caactcgagt tccgccaata 3780 atcccgccag cctgaacgag gagaagctgc tgctgctgat ggcccagctc gaggccctga 3840 cccagcgcct gggcgagctg acccagcagg tggctcagct gcaggcggag acgcgggccg 3900 cggttgccac ggtgaaaacc aaataaaaaa tgaatcaata aataaacgga aacggttgtt 3960 gattttaaca cagagtcttg aatctttatt tgatttttcg cgcgcggtag gccctggacc 4020 accggtctcg atcattgagc acccggtgga tcttttccag gacccggtag aggtgggctt 4080 ggatgttgag gtacatgggc atgagcccgt cccgggggtg gaggtagctc cactgcaggg 4140 cctcgtgctc gggggtggtg ttgtaaatca cccagtcata gcaggggcgc agggcgtggt 4200 gctgcacgat gtccttgagg aggagactga tggccacggg cagtcccttg gtgtaggtgt 4260 tgacgaacct gttgagctgg gagggatgca tgcgggggga gatgagatgc atcttggcct 4320 ggatcttgag attggcgatg ttcccaccca gatcccgccg ggggttcatg ttgtgcagga 4380 ccaccagcac ggtgtatccg gtgcacttgg ggaatttgtc atgcaacttg gaagggaagg 4440 cgtgaaagaa tttggagacg cccttgtgac cgcccaggtt ttccatgcac tcatccatga 4500 tgatggcgat gggcccgtgg gcggcggcct gggcaaagac gtttcggggg tcggacacat 4560 cgtagttgtg gtcctgggtg agctcgtcat aggccatttt aatgaatttg gggcggaggg 4620 tgcccgactg ggggacaaag gtgccctcga tcccgggggc gtagttgccc tcgcagatct 4680 gcatctccca ggccttgagc tcggaggggg ggatcatgtc cacctgcggg gcgatgaaaa 4740 aaacggtttc cggggcgggg gagatgagct gggccgaaag caggttccgg agcagctggg 4800 acttgccgca gccggtgggg ccgtagatga ccccgatgac cggctgcagg tggtagttga 4860 gggagagaca gctgccgtcc tcgcggagga ggggggccac ctcgttcatc atctcgcgca 4920 catgcatgtt ctcgcgcacg agttccgcca ggaggcgctc gccccccagc gagaggagct 4980 cttgcagcga ggcgaagttt ttcagcggct tgagtccgtc ggccatgggc attttggaga 5040 gggtctgttg caagagttcc agacggtccc agagctcggt gatgtgctct agggcatctc 5100 gatccagcag acctcctcgt ttcgcgggtt ggggcggctg cgggagtagg gcaccaggcg 5160 atgggcgtcc agcgaggcca gggtccggtc cttccagggt cgcagggtcc gcgtcagcgt 5220 ggtctccgtc acggtgaagg ggtgcgcgcc gggctgggcg cttgcgaggg tgcgcttcag 5280 gctcatccgg ctggtcgaga accgctcccg gtcggtgccc tgcgcgtcgg ccaggtagca 5340 attgagcatg agttcgtagt tgagcgcctc ggccgcgtgg cccttggcgc ggagcttacc 5400 tttggaagtg tgtccgcaga cgggacagag gagggacttg agggcgtaga gcttgggggc 5460 gaggaagacg gactcggggg cgtaggcgtc cgcgccgcag ctggcgcaga cggtctcgca 5520 ctccacgagc caggtgaggt cggggcggtc ggggtcaaaa acgaggtttc ctccgtgctt 5580 tttgatgcgt ttcttacctc tggtctccat gagctcgtgt ccccgctggg tgacaaagag 5640 gctgtccgtg tccccgtaga ccgactttat gggccggtcc tcgagcgggg tgccgcggtc 5700 ctcgtcgtag aggaaccccg cccactccga gacgaaggcc cgggtccagg ccagcacgaa 5760 ggaggccacg tgggaggggt agcggtcgtt gtccaccagc gggtccacct tctccagggt 5820 atgcaagcac atgtccccct cgtccacatc caggaaggtg attggcttgt aagtgtaggc 5880 cacgtgaccg ggggtcccgg ccgggggggt ataaaagggg gcgggcccct gctcgtcctc 5940 actgtcttcc ggatcgctgt ccaggagcgc cagctgttgg ggtaggtatt ccctctcgaa 6000 ggcgggcatg acctcggcac tcaggttgtc agtttctaga aacgaggagg atttgatatt 6060 gacggtgccg ttggagacgc ctttcatgag cccctcgtcc atctggtcag aaaagacgat 6120 ctttttgttg tcgagcttgg tggcgaagga gccgtagagg gcattggaga ggagcttggc 6180 gatggagcgc atggtctggt tcttttcctt gtcggcgcgc tccttggcgg cgatgttgag 6240 ctgcacgtac tcgcgcgcca cgcacttcca ttcggggaag acggtggtga gctcgtcggg 6300 cacgattctg acccgccagc cgcggttgtg cagggtgatg aggtccacgc tggtggccac 6360 ctcgccgcgc aggggctcgt tggtccagca gaggcgcccg cccttgcgcg agcagaaggg 6420 gggcagcggg tccagcatga gctcgtcggg ggggtcggcg tccacggtga agatgccggg 6480 caggagctcg gggtcgaagt agctgatgca ggtgcccaga tcgtccagcg ccgcttgcca 6540 gtcgcgcacg gccagcgcgc gctcgtaggg gctgaggggc gtgccccagg gcatggggtg 6600 cgtgagcgcg gaggcgtaca tgccgcagat gtcgtagacg tagaggggct cctcgaggac 6660 gccgatgtag gtggggtagc agcgcccccc gcggatgctg gcgcgcacgt agtcgtacag 6720 ctcgtgcgag ggcgcgagga gccccgcgcc gaggttggag cgctgcggct tttcggcgcg 6780 gtagacgatc tggcggaaga tggcgtggga gttggaggag atggtgggcc tctggaagat 6840 gttgaagtgg gcgtggggca ggccgaccga gtccctgatg aagtgggcgt aggagtcctg 6900 cagcttggcg acgagctcgg cggtgacgag gacgtccagg gcgcagtagt cgagggtctc 6960 ttggatgatg tcgtacttga gctggccctt ctgcttccac agctcgcggt tgagaaggaa 7020 ctcttcgcgg tccttccagt actcttcgag ggggaacccg tcctgatcgg cacggtaaga 7080 gcccaccatg tagaactggt tgacggcctt gtaggcgcag cagcccttct ccacggggag 7140 ggcataagct tgcgcggcct tgcgcaggga ggtgtgggtg agggcgaagg tgtcgcgcac 7200 catgaccttg aggaactggt gcttgaagtc gaggtcgtcg cagccgccct gctcccagag 7260 ttggaagtcc gtgcgcttct tgtaggcggg gttgggcaaa gcgaaagtaa catcgttgaa 7320 gaggatcttg cccgcgcggg gcatgaagtt gcgagtgatg cggaaaggct ggggcacctc 7380 ggcccggttg ttgatgacct gggcggcgag gacgatctcg tcgaagccgt tgatgttgtg 7440 cccgacgatg tagagttcca cgaatcgcgg gcggcccttg acgtggggca gcttcttgag 7500 ctcgtcgtag gtgagctcgg cggggtcgct gagtccgtgc tgctcaaggg cccagtcggc 7560 gacgtggggg ttggcgctga ggaaggaagt ccagagatcc acggccaggg cggtttgcaa 7620 gcggtcccgg tactgacgga actgctggcc cacggccatt ttttcggggg tgatgcagta 7680 gaaggtgcgg gggtcgccgt gccagcggtc ccacttgagc tggagggcga ggtcgtgggc 7740 gagctcgaca agcggcgggt ccccggagag tttcatgacc agcatgaagg ggacgagctg 7800 cttgccgaag gaccccatcc aggtgtaggt ttccacatcg taggtgagga agagcctttc 7860 ggtgcgagga tgcgagccga tggggaagaa ctggatctcc tgccaccagt tggaggaatg 7920 gctgttgatg tgatggaagt agaaatgccg acggcgcgcc gagcactcgt gcttgtgttt 7980 atacaagcgt ccgcagtgct cgcaacgctg cacgggatgc acgtgctgca cgagctgtac 8040 ctgagttcct ttgacgagga atttcagtgg gcagtggagc gctggcggct gcatctggtg 8100 ctgtactacg tcctggccat cggcgtggcc atcgtctgcc tcgatggtgg tcatgctgac 8160 gagcccgcgc gggaggcagg tccagacctc ggctcggacg ggtcggagag cgaggacgag 8220 ggcgcgcagg ccggagctgt ccagggtcct gagacgctgc ggagtcaggt cagtgggcag 8280 cggcggcgcg cggttgactt gcaggagctt ttccagggcg cgcgggaggt ccagatggta 8340 cttgatctcc acggcgccgt tggtggcgac gtccacggct tgcagggtcc cgtgcccctg 8400 gggcgccacc accgtgcccc gtttcttctt gggcgctggc ggcgttggcg ctggttccat 8460 gtcggtcaga agcggcggcg aggacgcgcg ccgggcggca ggggcggctc ggggcccgga 8520 ggcaggggcg gcaggggcac gtcggcgccg cgcgcgggca ggttctggta ctgcgcccgg 8580 agaagactgg cgtgagcgac gacgcgacgg ttgacgtcct ggatctgacg cctctgggtg 8640 aaggccacgg gacccgtgag tttgaacctg aaagagagtt cgacagaatc aatctcggta 8700 tcgttgacgg cggcctgccg caggatctct tgcacgtcgc ccgagttgtc ctggtaggcg 8760 atctcggtca tgaactgctc gatctcctcc tcctgaaggt ctccgcggcc ggcgcgctcg 8820 acggtggccg cgaggtcgtt ggagatgcgg gccatgagct gcgagaaggc gttcatgccg 8880 gcctcgttcc agacgcggct gtagaccacg gctccgtcgg ggtcgcgcgc gcgcatgacc 8940 acctgggcaa ggttgagctc gacgtggcgc gtgaagaccg cgtagttgca gaggcgctgg 9000 tagaggtagt tgagcgtggt ggcgatgtgc tcggtgacga agaagtacat gatccagcgg 9060 cggagcggca tctcgctgac gtcgcccagg gcttccaagc gctccatggc ctcgtagaag 9120 tccacggcga agttgaaaaa ctgggagttg cgcgccgaga cggtcaactc ctcctccaga 9180 agacggatga gctctgcgat ggtggcgcgc acctcgcgct cgaaggcccc ggggggctcc 9240 tcttcttcca tctcctcctc ctcttcctcc tccactaaca tctcttctac ttcctcctca 9300 ggcggtggtg gcgggggagg gggcctgcgt cgccggcggc gcacgggcag acggtcgatg 9360 aagcgctcga tggtctcgcc gcgccggcgt cgcatggtct cggtgacggc gcgcccgtcc 9420 tcgcggggcc gcagcgtgaa gacgccgccg cgcatctcca ggtggccggg ggggtccccg 9480 ttgggcaggg agagggcgct gacgatgcat cttatcaatt gccccgtagg gactccgcgc 9540 aaggacctga gcgtctcgag atccacggga tctgaaaacc gttgaacgaa ggcttcgagc 9600 cagtcgcagt cgcaaggtag gctgagcacg gtttcttctg gcgggtcatg ttggttggag 9660 ggagcggggc gggcgatgct gctggtgatg aagttgaaat aggcggttct gagacggcgg 9720 atggtggcga ggagcaccag gtctttgggc ccggcttgct ggatgcgcag acggtcggcc 9780 atgccccagg cgtggtcctg acacctggcc aggtccttgt agtagtcctg catgagccgc 9840 tccacgggca cctcctcctc gcccgcgcgg ccgtgcatgc gcgtgagccc gaagccgcgc 9900 tggggctgga cgagcgccag gtcggcgacg acgcgctcgg cgaggatggc ctgctggacc 9960 tgggtgaggg tggtctggaa gtcgtcgaag tcgacgaagc ggtggtaggc tccggtgttg 10020 atggtgtagg agcagttggc catgacggac cagttgacgg tctggtggcc ggggcgcacg 10080 agctcgtggt acttgaggcg cgagtaggcg cgcgtgtcga agatgtagtc gttgcaggtg 10140 cgcacgaggt actggtatcc gacgaggaag tgcggcggcg gctggcggta gagcggccat 10200 cgctcggtgg cgggggcgcc gggcgcgagg tcctcgagca tgaggcggtg gtagccgtag 10260 atgtacctgg acatccaggt gatgccggcg gcggtggtgg aggcgcgcgg gaactcgcgg 10320 acgcggttcc agatgttgcg cagcggcagg aagtagttca tggtggccgc ggtctggccc 10380 gtgaggcgcg cgcagtcgtg gatgctctag acatacgggc aaaaacgaaa gcggtcagcg 10440 gctcgactcc gtggcctgga ggctaagcga acgggttggg ctgcgcgtgt accccggttc 10500 gagtctctgc tcgaatcagg ctggagccgc agctaacgtg gtactggcac tcccgtctcg 10560 acccaagcct gctaacgaaa cctccaggat acggaggcgg gtcgtttttt ggccttggtc 10620 actggtcatg aaaaactagt aagcgcggaa agcggccgcc cgcgatggct cgctgccgta 10680 gtctggagaa agaatcgcca gggttgcgtt gcggtgtgcc ccggttcgag actcagcgct 10740 cggcgccggc cggattccgc ggctaacgtg ggcgtggctg ccccgtcgtt tccaagaccc 10800 cttagccagc cgacttctcc agttacggag cgagcccctc tttttcttgt gtttttgcca 10860 gatgcatccc gtactgcggc agatgcgccc ccaccctcca ccacaaccgc ccctaccgcc 10920 gcagcagcag caacagccgg cgcttctgcc cccgccccag cagcagccag ccactaccgc 10980 ggcggccgcc gtgagcggag ccggcgttca gtatgacctg gccttggaag agggcgaggg 11040 gctggcgcgg ctgggggcgt cgtcgccgga gcggcacccg cgcgtgcaga tgaaaaggga 11100 cgctcgcgag gcctacgtgc ccaagcagaa cctgttcaga gacaggagcg gcgaggagcc 11160 cgaggagatg cgcgcctccc gcttccacgc ggggcgggag ctgcggcgcg gcctggaccg 11220 aaagcgggtg ctgagggacg aggatttcga ggcggacgag ctgacgggga tcagccccgc 11280 gcgcgcgcac gtggccgcgg ccaacctggt cacggcgtac gagcagaccg tgaaggagga 11340 gagcaacttc caaaaatcct tcaacaacca cgtgcgcacg ctgatcgcgc gcgaggaggt 11400 gaccctgggc ctgatgcatc tgtgggacct gttggaggcc atcgtgcaga accccacgag 11460 caagccgctg acggcgcagc tgtttctggt ggtgcagcac agtcgggaca acgagacgtt 11520 cagggaggcg ctgctgaata tcaccgagcc cgagggccgc tggctcctgg acctggtgaa 11580 cattctgcag agcatcgtgg tgcaggagcg cgggctgccg ctgtccgaga agctggcggc 11640 catcaacttc tcggtgctga gcctgggcaa gtactacgct aggaagatct acaagacccc 11700 gtacgtgccc atagacaagg aggtgaagat cgacgggttt tacatgcgca tgaccctgaa 11760 agtgctgacc ctgagcgacg atctgggggt gtaccgcaac gacaggatgc accgcgcggt 11820 gagcgccagc cgccggcgcg agctgagcga ccaggagctg atgcacagcc tgcagcgggc 11880 cctgaccggg gccgggaccg agggggagag ctactttgac atgggcgcgg acctgcgctg 11940 gcagcccagc cgccgggctt tagaggcagc cggcggcgtg ccctacgtgg aggaggtgga 12000 cgatgatgag gaggagggcg agtacctgga agactgatgg cgcgaccgta tttttgctag 12060 atgcagcaac agccaccgcc tcctgatccc gcgatgcggg cggcgctgca gagccagccg 12120 tccggcatta actcctcgga cgattggacc caggccatgc aacgcatcat ggcgctgacg 12180 acccgcaatc ccgaagcctt tagacagcag cctcaggcca accggctctc ggccatcctg 12240 gaggccgtgg tgccctcgcg ctcgaacccc acgcacgaga aggtgctggc catcgtgaac 12300 gcgctggtgg agaacaaggc catccgcggc gacgaggccg ggctggtgta caacgcgctg 12360 ctggagcgcg tggcccgcta caacagcacc aacgtgcaga cgaacctgga ccgcatggtg 12420 accgacgtgc gcgaggcggt gtcgcagcgc gagcggttcc accgcgagtc gaacctgggc 12480 tccatggtgg cgctgaacgc cttcctgagc acgcagcccg ccaacgtgcc ccggggccag 12540 gaggactaca ccaactttat cagcgcgctg cggctgatgg tggccgaggt gccccagagc 12600 gaggtgtacc agtcggggcc ggactacttc ttccagacca gtcgccaggg cttgcagacc 12660 gtgaacctga gccaggcttt caagaacttg cagggactgt ggggcgtgca ggccccggtc 12720 ggggaccgcg cgacggtgtc gagcctgctg acgccgaact cgcgcctgct gctgctgctg 12780 gtggcgccct tcacggacag cggcagcgtg agccgcgact cgtacctggg ctacctgctt 12840 aacctgtacc gcgaggccat cgggcaggcg cacgtggacg agcagaccta ccaggagatc 12900 acccacgtga gccgcgcgct gggccaggag gacccgggca acctggaggc caccctgaac 12960 ttcctgctga ccaaccggtc gcagaagatc ccgccccagt acgcgctgag caccgaggag 13020 gagcgcatcc tgcgctacgt gcagcagagc gtggggctgt tcctgatgca ggagggggcc 13080 acgcccagcg ccgcgctcga catgaccgcg cgcaacatgg agcccagcat gtacgcccgc 13140 aaccgcccgt tcatcaataa gctgatggac tacttgcatc gggcggccgc catgaactcg 13200 gactacttta ccaacgccat cttgaacccg cactggctcc cgccgcccgg gttctacacg 13260 ggcgagtacg acatgcccga ccccaacgac gggttcctgt gggacgacgt ggacagcagc 13320 gtgttctcgc cgcgccccac caccaccgtg tggaagaaag agggcgggga ccggcggccg 13380 tcctcggcgc tgtccggtcg cgcgggtgct gccgcggcgg tgcccgaggc cgccagcccc 13440 ttcccgagcc tgcccttttc gctgaacagc gtgcgcagca gcgagctggg tcggctgacg 13500 cggccgcgcc tgctgggcga ggaggagtac ctgaacgact ccttgttgag gcccgagcgc 13560 gagaaaaact tccccaataa cgggatagag agcctggtgg acaagatgag ccgctggaag 13620 acgtacgcgc acgagcacag ggacgagccc cgagctagca gcagcgccgg cgccacccgt 13680 agacgccagc ggcacgacag gcagcgggga ctggtgtggg acgatgagga ttccgccgac 13740 gacagcagcg tgttggactt gggtgggagt ggtggtggta acccgttcgc tcacttgcgc 13800 ccccgtatcg ggcgcctgat gtaagaatct gaaaaaataa aaaaacggta ctcaccaagg 13860 ccatggcgac cagcgtgcgt tcttctctgt tgtttgtagt agtatgatga ggcgcgtgta 13920 cccggagggt cctcctccct cgtacgagag cgtgatgcag caggcggtgg cggcggcgat 13980 gcagcccccg ctggaggcgc cttacgtgcc cccgcggtac ctggcgccta cggaggggcg 14040 gaacagcatt cgttactcgg agctggcacc cttgtacgat accacccggt tgtacctggt 14100 ggacaacaag tcggcggaca tcgcctcgct gaactaccag aacgaccaca gcaacttcct 14160 gaccaccgtg gtgcagaaca acgatttcac ccccacggag gccagcaccc agaccatcaa 14220 ctttgacgag cgctcgcggt ggggcggcca gctgaaaacc atcatgcaca ccaacatgcc 14280 caacgtgaac gagttcatgt acagcaacaa gttcaaggcg cgggtgatgg tctcgcgcaa 14340 gacccccaac ggggtgacgg tggatgagaa ttatgatggt agtcaggacg agctgaccta 14400 cgagtgggtg gagtttgagc tgcccgaggg caacttctcg gtgaccatga ccatcgatct 14460 gatgaacaac gccatcatcg acaactactt ggcggtggga cggcagaacg gggtgctgga 14520 gagcgacatc ggcgtgaagt tcgacacgcg caacttccgg ctgggctggg accccgtgac 14580 cgagctggtg atgccgggcg tgtacaccaa cgaggccttc caccccgaca tcgtcctgct 14640 gcccggctgc ggcgtggact tcaccgagag ccgcctcagc aacctgctgg gcatccgcaa 14700 gcggcagccc ttccaggagg gcttccagat cctgtacgag gacctggagg ggggcaacat 14760 ccccgcgctg ctggacgtcg aagcctacga gaaaagcaag gaggaggccg ccgcagcggc 14820 gaccgcggcc gtggctaccg ctgcgaccac cgatgcagat gcagctacta ctaccagggg 14880 cgatacattc gccacccagg cggaggaagc agccgcccta gcggcgaccg atgatagtga 14940 aagtaagata gtcatcaagc cggtggagaa ggacagcaag gacaggagct acaacgttct 15000 atcggatgga aagaacaccg cctaccgcag ctggtacctg gcctacaact acggcgaccc 15060 tgagaagggc gtgcgctcct ggacgctgct caccacctcg gacgtcacct gcggcgtgga 15120 gcaagtctac tggtcgctgc ccgacatgat gcaagacccg gtcaccttcc gctccacgcg 15180 tcaagttagc aactacccgg tggtgggcgc cgagctcctg cccgtctact ccaagagctt 15240 cttcaacgag caggccgtct actcgcagca gctgcgcgcc ttcacctcgc tcacgcacgt 15300 cttcaaccgc ttccccgaga accagatcct cgtccgcccg cccgcgccca ccattaccac 15360 cgtcagtgaa aacgttcctg ctctcacaga tcacgggacc ctgccgctgc gcagcagtat 15420 ccggggagtc cagcgcgtga ccgtcactga cgccagacgc cgcacctgcc cctacgtcta 15480 caaggccctg ggcgtagtcg cgccgcgcgt cctctcgagc cgcaccttct aaaaaatgtc 15540 cattctcatc tcgcccagta ataacaccgg ttggggcctg cgcgcgccca gcaagatgta 15600 cggaggcgct cgccaacgct ccacgcaaca ccccgtgcgc gtgcgcgggc acttccgcgc 15660 tccctggggc gccctcaagg gccgcgtgcg ctcgcgcacc accgtcgacg acgtgatcga 15720 ccaggtggtg gccgacgcgc gcaactacac gcccgccgcc gcgcccgcct ccaccgtgga 15780 cgccgtcatc gacagcgtgg tggccgacgc gcgccggtac gcccgcgcca agagccggcg 15840 gcggcgcatc gcccggcggc accggagcac ccccgccatg cgcgcggcgc gagccttgct 15900 gcgcagggcc aggcgcacgg gacgcagggc catgctcagg gcggccagac gcgcggcctc 15960 cggcagcagc agcgccggca ggacccgcag acgcgcggcc acggcggcgg cggcggccat 16020 cgccagcatg tcccgcccgc ggcgcggcaa cgtgtactgg gtgcgcgacg ccgccaccgg 16080 tgtgcgcgtg cccgtgcgca cccgcccccc tcgcacttga agatgctgac ttcgcgatgt 16140 tgatgtgtcc cagcggcgag gaggatgtcc aagcgcaaat tcaaggaaga gatgctccag 16200 gtcatcgcgc ctgagatcta cggccccgcg gcggcggtga aggaggaaag aaagccccgc 16260 aaactgaagc gggtcaaaaa ggacaaaaag gaggaggaag atgacggact ggtggagttt 16320 gtgcgcgagt tcgccccccg gcggcgcgtg cagtggcgcg ggcggaaagt gaaaccggtg 16380 ctgcggcccg gcaccacggt ggtcttcacg cccggcgagc gttccggctc cgcctccaag 16440 cgctcctacg acgaggtgta cggggacgag gacatcctcg agcaggcggc cgagcgtctg 16500 ggcgagtttg cttacggcaa gcgcagccgc cccgcgccct tgaaagagga ggcggtgtcc 16560 atcccgctgg accacggcaa ccccacgccg agcctgaagc cggtgaccct gcagcaggtg 16620 ctgccgagcg cggcgccgcg ccggggcttc aagcgcgagg gcggcgagga tctgtacccg 16680 accatgcagc tgatggtgcc caagcgccag aagctggagg acgtgctgga gcacatgaag 16740 gtggaccccg aggtgcagcc cgaggtcaag gtgcggccca tcaagcaggt ggccccgggc 16800 ctgggcgtgc agaccgtgga catcaagatc cccacggagc ccatggaaac gcagaccgag 16860 cccgtgaagc ccagcaccag caccatggag gtgcagacgg atccctggat gccggcgccg 16920 gcttccacca ccaccaccac ccgccgaaga cgcaagtacg gcgcggccag cctgctgatg 16980 cccaactacg cgctgcatcc ttccatcatc cccacgccgg gctaccgcgg cacgcgcttc 17040 taccgcggct acagcagccg ccgcaagacc accacccgcc gccgccgtcg ccgcacccgc 17100 cgcagcacca ccgcgacttc cgccgccgcc ttggtgcgga gagtgtaccg cagcgggcgt 17160 gagcctctga ccctgccgcg cgcgcgctac cacccgagca tcgccattta actctgccgt 17220 cgcctccttg cagatatggc cctcacatgc cgcctccgcg tccccattac gggctaccga 17280 ggaagaaagc cgcgccgtag aaggctgacg gggaacgggc tgcgtcgcca tcaccaccgg 17340 cggcggcgcg ccatcagcaa gcggttgggg ggaggcttcc tgcccgcgct gatccccatc 17400 atcgccgcgg cgatcggggc gatccccggc atagcttccg tggcggtgca ggcctctcag 17460 cgccactgag acacagcttg gaaaatttgt aataaaaaaa tggactgacg ctcctggtcc 17520 tgtgatgtgt gtttttagat ggaagacatc aatttttcgt ccctggcacc gcgacacggc 17580 acgcggccgt ttatgggcac ctggagcgac atcggcaaca gccaactgaa cgggggcgcc 17640 ttcaattgga gcagtctctg gagcgggctt aagaatttcg ggtccacgct caaaacctat 17700 ggcagcaagg cgtggaacag caccacaggg caggcgctga gggataagct gaaagagcag 17760 aacttccagc agaaggtggt cgatgggctc gcttcgggca tcaacggggt ggtggacctg 17820 gccaaccagg ccgtgcagcg gcagatcaac agccgcctgg acccggtgcc gcccgccggc 17880 tccgtggaga tgccgcaggt ggaggaggag ctgcctcccc tggacaagcg gggcgagaag 17940 cgaccccgcc ccgacgcgga ggagacgctg ctgacgcaca cggacgagcc gcccccgtac 18000 gaggaggcgg tgaaactggg tctgcccacc acgcggccca ttgcgcccct agccaccggg 18060 gtgctgaaac ccgagagtaa taagcccgcg accctggact tgcctcctcc ccagccttcc 18120 cgcccctcca cagtggctaa gcccctgccg ccggtggccg tggcccgcgc gcgacccggg 18180 ggctccgccc gccctcatgc gaactggcag agcactctga acagcatcgt gggtctggga 18240 gtgcagagtg tgaagcgccg ccgctgctat taaacctacc gtagcgctta acttgcttgt 18300 ctgtgtgtgt atgtattatg tcgccgccgc tgtccgccag aaggaggagt gaagaggcgc 18360 gtcgccgagt tgcaagatgg ccaccccatc gatgctgccc cagtgggcgt acatgcacat 18420 cgccggacag gacgcttcgg agtacctgag tccgggtctg gtgcagttcg cccgcgccac 18480 agacacctac ttcagtctgg ggaacaagtt taggaacccc acggtggcgc ccacgcacga 18540 tgtgaccacc gaccgcagcc agcggctgac gctgcgcttc gtgcccgtgg accgcgagga 18600 caacacctac tcgtacaaag tgcgctacac gctggccgtg ggcgacaacc gcgtgctgga 18660 catggccagc acctactttg acatccgcgg cgtgctggac cggggcccta gcttcaaacc 18720 ctactccggc accgcctaca acagcctggc tcccaaggga gcgcccaatt ccagccagtg 18780 ggagcgagct aagacaaaca ataacggagc cacggaatct gttacctttg gtgtggctgc 18840 catggggggt atagatatta caaaagaggg tctccagatt ggaactgatg aaactaaagc 18900 tgatagtaaa gaaatttatg cagacaaaac ctaccaacct gaacctcaga taggagagga 18960 gaactggcaa gaaacattct cctattatgg cggcagagct cttaaaaaag ataccaagat 19020 gaagccatgc tacggctcct ttgctaaacc aacgaatgtc aaaggaggtc aggccaaatt 19080 taaagttcag gacggtcaac aaactacaga atatgatatc gacttagctt tctttgatat 19140 tccaaactct ggaacaggag ggaatggcac gaatgttaat tatgatccag atatggtcat 19200 gtacactgaa aatgtggatt tggagacccc tgatacccac attgtttaca aaccagggac 19260 ttccgatgac agttctgaag caaacttgct tcagcagtcc atgcctaaca gacccaacta 19320 tattgggttt agagacaact ttatcggtct catgtactac aacagtactg gcaatatggg 19380 tgtgctggct ggtcaggcct cccagctgaa tgctgtggtc gacttgcaag acagaaacac 19440 cgagctatcc taccagctct tgcttgactc tctgggcgat agaacccggt atttcagtat 19500 gtggaaccag gcggtggaca gttatgaccc tgatgtgcgc attattgaaa accatggtgt 19560 ggaagatgaa cttcccaact attgcttccc attggatgga gctggtacta atgctgtcta 19620 tcagggtgtt aaagcaaaaa ctaatggagg cgcagccaat ggagattggg agcaagatac 19680 agacgtgtca aacattaacc agatatgcaa ggggaacatc tatgccatgg aaatcaacct 19740 ccaagccaac ctgtggagaa gtttcctcta ctcgaacgtg gccctgtacc tgcccgattc 19800 ttacaagtac acgccggcca acatcacctt gcccacgaat accaacacct atgattacat 19860 gaatgggaga gtggcgcctc cctcgttggt ggatgcctac atcaacatcg gggcgcgctg 19920 gtcgctggac cccatggaca acgtcaatcc cttcaaccac caccgcaacg cggggctgcg 19980 ctaccgctcc atgcttctgg gcaacgggcg cttcgtgccc ttccacatcc aggtgcccca 20040 gaaatttttc gccatcaaga gcctcctgct cctgcccggg tcctacacct acgagtggaa 20100 cttccgcaag gacgtcaaca tgatcctgca gagctccctc ggcaacgacc tgcgcacgga 20160 cggggcctcc atctccttca ccagcatcaa cctctacgcc accttcttcc ccatggcgca 20220 caacacggcc tccacgctcg aggccatgct gcgcaacgac accaacgacc agtccttcaa 20280 cgactacctc tcggcggcca acatgctcta ccccatccca gccaacgcca ccaacgtgcc 20340 catctccatc ccctcgcgca actgggccgc cttccgcggc tggtccttca cgcgtctcaa 20400 gaccaaggag acgccctcgc tgggctccgg gttcgacccc tacttcgtct actcgggctc 20460 catcccctac ctcgacggca ccttctacct caaccacacc ttcaagaagg tctccatcac 20520 cttcgactcc tccgtcagct ggcccggcaa cgaccggctc ctgacgccca acgagttcga 20580 aatcaagcgc accgtcgacg gcgagggcta caacgtggcc cagtgcaaca tgaccaagga 20640 ctggttcctg gtccagatgc tggcccacta caacatcggc taccagggct tctacgtgcc 20700 cgagggctac aaggaccgca tgtactcctt cttccgcaac ttccagccca tgagccgcca 20760 ggtggtggac gaggtcaact acaaggacta ccaggccgtc accctggcct accagcacaa 20820 caactcgggc ttcgtcggct acctcgcgcc caccatgcgc cagggccagc cctaccccgc 20880 caactacccg tacccgctca tcggcaagag cgccgtcacc agcgtcaccc agaaaaagtt 20940 cctctgcgac agggtcatgt ggcgcatccc cttctccagc aacttcatgt ccatgggcgc 21000 gctcaccgac ctcggccaga acatgctcta tgccaactcc gcccacgcgc tagacatgaa 21060 tttcgaagtc gaccccatgg atgagtccac ccttctctat gttgtcttcg aagtcttcga 21120 cgtcgtccga gtgcaccagc cccaccgcgg cgtcatcgag gccgtctacc tgcgcacccc 21180 cttctcggcc ggtaacgcca ccacctaagc tcttgcttct tgcaagatgg ctgagcccac 21240 gggctccggc gagcaggagc tcagggccat catccgcgac ctgggctgcg ggccctactt 21300 cctgggcacc ttcgataagc gcttcccggg attcatggcc ccgcacaagc tggcctgcgc 21360 catcgtcaac acggccggcc gcgagaccgg gggcgagcac tggctggcct tcgcctggaa 21420 cccgcgctcg aacacctgct acctcttcga ccccttcggg ttctcggacg agcgcctcaa 21480 gcagatctac cagttcgagt acgagggcct gctgcgccgc agcgccctgg ccaccgagga 21540 ccgctgcgtc accctggaaa agtccaccca gaccgtgcag ggtccgcgct cggccgcctg 21600 cgggctcttt tgctgcatgt tcctgcacgc cttcgtgcac tggcccgacc gccccatgga 21660 caagaacccc accatgaact tgctgacggg ggtgcccaac ggcatgctcc agtcgcccca 21720 ggtggaaccc accctgcgcc gcaaccagga ggcgctctac cgcttcctca acgcccactc 21780 cgcctacttt cgctcccacc gcgcgcgcat cgagaaggcc accgccttcg accgcatgaa 21840 tcaagacatg taaaccgtgt gtgtatgtga atgctttatt cataataaac agcacatgtt 21900 tatgccacct tctctgaggc tctgacttta tttagaaatc gaaggggttc tgccggctct 21960 cggcgtgccc cgcgggcagg gatacgttgc ggaactggta cttgggcagc cacttgaact 22020 cggggatcag cagcttcggc acggggaggt cggggaacga gtcgctccac agcttgcgcg 22080 tgagttgcag ggcgcccagc aggtcgggcg cggagatctt gaaatcgcag ttgggacccg 22140 cgttctgcgc gcgagagttg cggtacacgg ggttgcagca ctggaacacc atcagggccg 22200 ggtgcttcac gctcgccagc accgtcgcgt cggtgatgcc ctccacgtcc agatcctcgg 22260 cgttggccat cccgaagggg gtcatcttgc aggtctgccg ccccatgctg ggcacgcagc 22320 cgggcttgtg gttgcaatcg cagtgcaggg ggatcagcat catctgggcc tgctcggagc 22380 tcatgcccgg gtacatggcc ttcatgaaag cctccagctg gcggaaggcc tgctgcgcct 22440 tgccgccctc ggtgaagaag accccgcagg acttgctaga gaactggttg gtagcgcagc 22500 ccgcgtcgtg cacgcagcag cgcgcgtcgt tgttggccag ctgcaccacg ctgcgccccc 22560 agcggttctg ggtgatcttg gcccggtcgg ggttctcctt cagcgcgcgc tgcccgttct 22620 cgctcgccac atccatctcg atcgtgtgct ccttctggat catcacggtc ccgtgcaggc 22680 accgcagctt gccctcggcc tcggtgcagc cgtgcagcca cagcgcgcag ccggtgctct 22740 cccagttctt gtgggcgatc tgggagtgcg agtgcacgaa gccctgcagg aagcggccca 22800 tcatcgcggt cagggtcttg ttgctggtga aggtcagcgg gatgccgcgg tgctcctcgt 22860 tcacatacag gtggcagatg cggcggtaca cctcgccctg ctcgggcatc agctggaagg 22920 cggacttcag gtcgctctcc acgcggtacc ggtccatcag cagcgtcatc acttccatgc 22980 ccttctccca ggccgaaacg atcggcaggc tcagggggtt cttcaccgtc atcttagtcg 23040 ccgccgccga agtcaggggg tcgttctcgt ccagggtctc aaacactcgc ttgccgtcct 23100 tctcggtgat gcgcacgggg gggaaggcga agcccacggc cgccagctcc tcctcggcct 23160 gcctttcgtc ctcgctgtcc tggctgatgt cttgcaaagg cacatgcttg gtcttgcggg 23220 gtttcttttt gggcggcaga ggcggcggcg gcggagacgt gctgggcgag cgcgagttct 23280 cgctcaccac gactatttct tcttcttggc cgtcgtccga gaccacgcgg cggtaggcat 23340 gcctcttctg gggcagaggc ggaggcgacg ggctctcgcg gttcggcggg cggctggcag 23400 agccccttcc gcgttcgggg gtgcgctcct ggcggcgctg ctctgactga cttcctccgc 23460 ggccggccat tgtgttctcc tagggagcaa caacaagc atg gag act cag cca tcg 23516 Met Glu Thr Gln Pro Ser 1 5 tcg cca aca tcg cca tct gcc ccc gcc gcc gcc gac gag aac cag cag 23564 Ser Pro Thr Ser Pro Ser Ala Pro Ala Ala Ala Asp Glu Asn Gln Gln 10 15 20 cag cag aat gaa agc tta acc gcc ccg ccg ccc agc ccc acc tcc gac 23612 Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro Pro Ser Pro Thr Ser Asp 25 30 35 gcc gcg gcc cca gac atg caa gag atg gag gaa tcc atc gag att gac 23660 Ala Ala Ala Pro Asp Met Gln Glu Met Glu Glu Ser Ile Glu Ile Asp 40 45 50 ctg ggc tac gtg acg ccc gcg gag cac gag gag gag ctg gca gcg cgc 23708 Leu Gly Tyr Val Thr Pro Ala Glu His Glu Glu Glu Leu Ala Ala Arg 55 60 65 70 ttt tca gcc ccg gaa gag aac cac caa gag cag cca gag cag gaa gca 23756 Phe Ser Ala Pro Glu Glu Asn His Gln Glu Gln Pro Glu Gln Glu Ala 75 80 85 gag agc gag cag agc cag gct ggg ctc gag cat ggc gac tac ctg agc 23804 Glu Ser Glu Gln Ser Gln Ala Gly Leu Glu His Gly Asp Tyr Leu Ser 90 95 100 ggg gca gag gac gtg ctc atc aag cat ctg gcc cgc caa tgc atc atc 23852 Gly Ala Glu Asp Val Leu Ile Lys His Leu Ala Arg Gln Cys Ile Ile 105 110 115 gtc aag gac gcg ctg ctc gac cgc gcc gag gtg ccc ctc agc gtg gcg 23900 Val Lys Asp Ala Leu Leu Asp Arg Ala Glu Val Pro Leu Ser Val Ala 120 125 130 gag ctc agc cgc gcc tac gag cgc aac ctc ttc tcg ccg cgc gtg ccc 23948 Glu Leu Ser Arg Ala Tyr Glu Arg Asn Leu Phe Ser Pro Arg Val Pro 135 140 145 150 ccc aag cgc cag ccc aac ggc acc tgc gag ccc aac ccg cgc ctc aac 23996 Pro Lys Arg Gln Pro Asn Gly Thr Cys Glu Pro Asn Pro Arg Leu Asn 155 160 165 ttc tac ccg gtc ttc gcg gtg ccc gag gcc ctg gcc acc tac cac ctc 24044 Phe Tyr Pro Val Phe Ala Val Pro Glu Ala Leu Ala Thr Tyr His Leu 170 175 180 ttt ttc aag aac caa agg atc ccc gtc tcc tgc cgc gcc aac cgc acc 24092 Phe Phe Lys Asn Gln Arg Ile Pro Val Ser Cys Arg Ala Asn Arg Thr 185 190 195 cgc gcc gac gcc ctg ctc aac ctg ggc ccc ggc gcc cgc cta cct gat 24140 Arg Ala Asp Ala Leu Leu Asn Leu Gly Pro Gly Ala Arg Leu Pro Asp 200 205 210 atc gcc tcc ttg gaa gag gtt ccc aag atc ttc gag ggt ctg ggc agc 24188 Ile Ala Ser Leu Glu Glu Val Pro Lys Ile Phe Glu Gly Leu Gly Ser 215 220 225 230 gac gag act cgg gcc gcg aac gct ctg caa gga agc gga gag gag cat 24236 Asp Glu Thr Arg Ala Ala Asn Ala Leu Gln Gly Ser Gly Glu Glu His 235 240 245 gag cac cac agc gcc ctg gtg gag ttg gaa ggc gac aac gcg cgc ctg 24284 Glu His His Ser Ala Leu Val Glu Leu Glu Gly Asp Asn Ala Arg Leu 250 255 260 gcg gtc ctc aag cgc acg gtc gag ctg acc cac ttc gcc tac ccg gcg 24332 Ala Val Leu Lys Arg Thr Val Glu Leu Thr His Phe Ala Tyr Pro Ala 265 270 275 ctc aac ctg ccc ccc aag gtc atg agc gcc gtc atg gac cag gtg ctc 24380 Leu Asn Leu Pro Pro Lys Val Met Ser Ala Val Met Asp Gln Val Leu 280 285 290 atc aag cgc gcc tcg ccc ctc tcg gag gag gag atg cag gac ccc gag 24428 Ile Lys Arg Ala Ser Pro Leu Ser Glu Glu Glu Met Gln Asp Pro Glu 295 300 305 310 agc tcg gac gag ggc aag ccc gtg gtc agc gac gag cag ctg gcg cgc 24476 Ser Ser Asp Glu Gly Lys Pro Val Val Ser Asp Glu Gln Leu Ala Arg 315 320 325 tgg ctg gga acg agt agc acc ccc cag agt ctg gaa gag cgg cgc aag 24524 Trp Leu Gly Thr Ser Ser Thr Pro Gln Ser Leu Glu Glu Arg Arg Lys 330 335 340 ctc atg atg gcc gtg gtc ctg gtg acc gtg gag ctt gag tgt ctg cgc 24572 Leu Met Met Ala Val Val Leu Val Thr Val Glu Leu Glu Cys Leu Arg 345 350 355 cgc ttc ttc gcc gac gcg gag acc ctg cgc aag gtc gag gag aac ctg 24620 Arg Phe Phe Ala Asp Ala Glu Thr Leu Arg Lys Val Glu Glu Asn Leu 360 365 370 cac tac ctc ttc agg cac ggg ttc gtg cgc cag gcc tgc aag atc tcc 24668 His Tyr Leu Phe Arg His Gly Phe Val Arg Gln Ala Cys Lys Ile Ser 375 380 385 390 aac gtg gag ctg acc aac ctg gtc tcc tac atg ggc atc ctg cac gag 24716 Asn Val Glu Leu Thr Asn Leu Val Ser Tyr Met Gly Ile Leu His Glu 395 400 405 aac cgc ctg ggg cag aac gtg ctg cac acc acc ctg cgc ggg gag gcc 24764 Asn Arg Leu Gly Gln Asn Val Leu His Thr Thr Leu Arg Gly Glu Ala 410 415 420 cgc cgc gac tac atc cgc gac tgc gtc tac ctg tac ctc tgc cac acc 24812 Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr Leu Tyr Leu Cys His Thr 425 430 435 tgg cag acg ggc atg ggc gtg tgg cag cag tgc ctg gag gag cag aac 24860 Trp Gln Thr Gly Met Gly Val Trp Gln Gln Cys Leu Glu Glu Gln Asn 440 445 450 ctg aaa gag ctc tgc aag ctc ctg cag aag aac ctg aag gcc ctg tgg 24908 Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys Asn Leu Lys Ala Leu Trp 455 460 465 470 acc ggg ttc gac gag cgt acc acc gcc tcg gac ctg gcc gac ctc atc 24956 Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser Asp Leu Ala Asp Leu Ile 475 480 485 ttc ccc gag cgc ctg cgg ctg acg ctg cgc aac ggg ctg ccc gac ttt 25004 Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg Asn Gly Leu Pro Asp Phe 490 495 500 atg agc caa agc atg ttg caa aac ttt cgc tct ttc atc ctc gaa cgc 25052 Met Ser Gln Ser Met Leu Gln Asn Phe Arg Ser Phe Ile Leu Glu Arg 505 510 515 tcc ggg atc ctg ccc gcc acc tgc tcc gcg ctg ccc tcg gac ttc gtg 25100 Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala Leu Pro Ser Asp Phe Val 520 525 530 ccg ctg acc ttc cgc gag tgc ccc ccg ccg ctc tgg agc cac tgc tac 25148 Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro Leu Trp Ser His Cys Tyr 535 540 545 550 ttg ctg cgc ctg gcc aac tac ctg gcc tac cac tcg gac gtg atc gag 25196 Leu Leu Arg Leu Ala Asn Tyr Leu Ala Tyr His Ser Asp Val Ile Glu 555 560 565 gac gtc agc ggc gag ggt ctg ctc gag tgc cac tgc cgc tgc aac ctc 25244 Asp Val Ser Gly Glu Gly Leu Leu Glu Cys His Cys Arg Cys Asn Leu 570 575 580 tgc acg ccg cac cgc tcc ctg gcc tgc aac ccc cag ctg ctg agc gag 25292 Cys Thr Pro His Arg Ser Leu Ala Cys Asn Pro Gln Leu Leu Ser Glu 585 590 595 acc cag atc atc ggc acc ttc gag ttg caa ggc ccc ggc gag gag ggc 25340 Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln Gly Pro Gly Glu Glu Gly 600 605 610 aag ggg ggt ctg aaa ctc acc ccg ggg ctg tgg acc tcg gcc tac ttg 25388 Lys Gly Gly Leu Lys Leu Thr Pro Gly Leu Trp Thr Ser Ala Tyr Leu 615 620 625 630 cgc aag ttc gtg ccc gag gac tac cat ccc ttc gag atc agg ttc tac 25436 Arg Lys Phe Val Pro Glu Asp Tyr His Pro Phe Glu Ile Arg Phe Tyr 635 640 645 gag gac caa tcc cag ccg ccc aag gcc gag ctg tcg gcc tgc gtc atc 25484 Glu Asp Gln Ser Gln Pro Pro Lys Ala Glu Leu Ser Ala Cys Val Ile 650 655 660 acc cag ggg gcc atc ctg gcc caa ttg caa gcc atc cag aaa tcc cgc 25532 Thr Gln Gly Ala Ile Leu Ala Gln Leu Gln Ala Ile Gln Lys Ser Arg 665 670 675 caa gaa ttt ctg ctg aaa aag ggc cac ggg gtc tac ttg gac ccc cag 25580 Gln Glu Phe Leu Leu Lys Lys Gly His Gly Val Tyr Leu Asp Pro Gln 680 685 690 acc gga gag gag ctc aac ccc agc ttc ccc cag gat gcc cag agg aag 25628 Thr Gly Glu Glu Leu Asn Pro Ser Phe Pro Gln Asp Ala Gln Arg Lys 695 700 705 710 cag caa gaa gct gaa agt gga gct gcc gct gcc gcc gga gga ttt gga 25676 Gln Gln Glu Ala Glu Ser Gly Ala Ala Ala Ala Ala Gly Gly Phe Gly 715 720 725 gga aga ctg gga gag cag tca ggc aga gga gga gga gat gga aga ctg 25724 Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly Gly Gly Asp Gly Arg Leu 730 735 740 gga cag cac tca ggc aga gga gga cag cct gca aga cag tct gga aga 25772 Gly Gln His Ser Gly Arg Gly Gly Gln Pro Ala Arg Gln Ser Gly Arg 745 750 755 cga ggt gga gga ggc aga gga aga agc agc cgc cgc cag acc gtc gtc 25820 Arg Gly Gly Gly Gly Arg Gly Arg Ser Ser Arg Arg Gln Thr Val Val 760 765 770 ctc ggc gga gaa agc aag cag cac gga tac cat ctc cgc tcc ggg tcg 25868 Leu Gly Gly Glu Ser Lys Gln His Gly Tyr His Leu Arg Ser Gly Ser 775 780 785 790 ggg tct cgg cgg ccg ggc cca cag tagatgggac gagaccgggc gcttcccgaa 25922 Gly Ser Arg Arg Pro Gly Pro Gln 795 ccccaccacc cagaccggta agaaggagcg gcagggatac aagtcctggc gggggcacaa 25982 aaacgccatc gtctcctgct tgcaagcctg cgggggcaac atctccttca cccggcgcta 26042 cctgctcttc caccgcgggg tgaacttccc ccgcaacatc ttgcattact accgtcacct 26102 ccacagcccc tactactgtt tccaagaaga ggcagaaacc cagcagcagc agaaaaccag 26162 cagcagctag aaaatccaca gcggcggcgg cggcaggtgg actgaggatc gcggcgaacg 26222 agccggcgca gacccgggag ctgaggaacc ggatctttcc caccctctat gccatcttcc 26282 agcagagtcg ggggcaggag caggaactga aagtcaagaa ccgttctctg cgctcgctca 26342 cccgcagttg tctgtatcac aagagcgaag accaacttca gcgcactctc gaggacgccg 26402 aggctctctt caacaagtac tgcgcgctca ctcttaaaga gtagcccgcg cccgcccaca 26462 cacggaaaaa ggcgggaatt acgtcaccac ctgcgccctt cgcccgacca tcatcatgag 26522 caaagagatt cccacgcctt acatgtggag ctaccagccc cagatgggcc tggccgccgg 26582 cgccgcccag gactactcca cccgcatgaa ctggctcagt gccgggcccg cgatgatctc 26642 acgggtgaat gacatccgcg cccaccgaaa ccagatactc ctagaacagt cagcgatcac 26702 cgccacgccc cgccatcacc ttaatccgcg taattggccc gccgccctgg tgtaccagga 26762 aattccccag cccacgaccg tactacttcc gcgagacgcc caggccgaag tccagctgac 26822 taactcaggt gtccagctgg ccggcggcgc cgccctgtgt cgtcaccgcc ccgctcaggg 26882 tataaagcgg ctggtgatcc gaggcagagg cacacagctc aacgacgagg tggtgagctc 26942 ttcgctgggt ctgcgacctg acggagtctt ccaactcgcc ggatcgggga gatcttcctt 27002 cacgcctcgt caggccgtcc tgactttgga gagttcgtcc tcgcagcccc gctcgggtgg 27062 catcggcact ctccagttcg tggaggagtt cactccctcg gtctacttca accccttctc 27122 cggctccccc ggccactacc cggacgagtt catcccgaac ttcgacgcca tcagcgagtc 27182 ggtggacggc tacgattgaa tgtcccatgg tggcgcggct gacctagctc ggcttcgaca 27242 cctggaccac tgccgccgct tccgctgctt cgctcgggat ctcgccgagt ttgcctactt 27302 tgagctgccc gaggagcacc ctcagggccc ggcccacgga gtgcggatca tcgtcgaagg 27362 gggcctcgac tcccacctgc ttcggatctt cagccagcgt ccgatcctgg tcgagcgcga 27422 gcaaggacag acccgtctga ccctgtactg catctgcaac caccccggcc tgc atg 27478 Met aaa gtc ttt gtt gtc tgc tgt gta ctg agt ata ata aaa gct gag atc 27526 Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu Ile 800 805 810 815 agc gac tac tcc gga ctt ccg tgt gtt cct gaa tcc atc aac cag tcc 27574 Ser Asp Tyr Ser Gly Leu Pro Cys Val Pro Glu Ser Ile Asn Gln Ser 820 825 830 ctg ttc ttc acc ggg aac gag acc gag ctc cag ctc cag tgt aag ccc 27622 Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys Pro 835 840 845 cac aag aag tac ctc acc tgg ctg ttc cag ggc tcc ccg atc gcc gtt 27670 His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala Val 850 855 860 gtc aac cac tgc gac aac gac gga gtc ctg ctg agc ggc cct gcc aac 27718 Val Asn His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala Asn 865 870 875 ctt act ttt tcc acc cgc aga agc aag ctc cag ctc ttc caa ccc ttc 27766 Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro Phe 880 885 890 895 ctc ccc ggg acc tat cag tgc gtc tcg gga ccc tgc cat cac acc ttc 27814 Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro Cys His His Thr Phe 900 905 910 cac ctg atc ccg aat acc aca gcg tcg ctc ccc gct act aac aac caa 27862 His Leu Ile Pro Asn Thr Thr Ala Ser Leu Pro Ala Thr Asn Asn Gln 915 920 925 act acc cac caa cgc cac cgt cgc gac ctt tcc tct gaa tct aat acc 27910 Thr Thr His Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser Asn Thr 930 935 940 act acc gga ggt gag ctc cga ggt cga cca acc tct ggg att tac tac 27958 Thr Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile Tyr Tyr 945 950 955 ggc ccc tgg gag gtg gtg ggg tta ata gcg cta ggc cta gtt gtg ggt 28006 Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val Val Gly 960 965 970 975 ggg ctt ttg gct ctc tgc tac cta tac ctc cct tgc tgt tcg tac tta 28054 Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser Tyr Leu 980 985 990 gtg gtg ctg tgt tgc tgg ttt aag aaa tgg ggc aga tca ccc 28096 Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 995 1000 1005 tagtgagctg cggtgtgctg gtggcggtgg tgctttcgat tgtgggactg ggcggcgcgg 28156 ctgtagtgaa ggagaaggcc gatccctgct tgcatttcaa tcccgataaa tgccagctga 28216 gttttcagcc cgatggcaat cggtgcgcgg tgctgatcaa gtgcggatgg gaatgcgaga 28276 acgtgagaat cgagtacaat aacaagactc ggaacaatac tctcgcgtcc acgtggcagc 28336 ccggggaccc cgagtggtac accgtctctg tccccggtgc tgacggctcc ccgcgcaccg 28396 tgaataatac tttcattttt gcgcacatgt gcgacacggt catgtggatg agcaagcagt 28456 acgatatgtg gccccccacg aaggagaaca tcgtggtctt ctccatcgct tacagcctgt 28516 gcacggtgct aatcaccgct atcgtgtgcc tgagcattca catgctcatc gctattcgcc 28576 ccagaaataa tgccgaaaaa gaaaaacagc cataacacgt tttttcacac acctttttca 28636 gaccatggcc tctgttaaat ttttgctttt atttgccagt ctcattactg ttataagtaa 28696 tgagaaactc actatttaca ttggcactaa ccacactcta gaaggaattc caaaatcctc 28756 atggtattgc tattttgatc aagatccaga cttaactata gaactgtgtg gtaacaaggg 28816 acaaaataca agcattcatt taattaactt taaatgcgga gacgatttga aattaattaa 28876 tatcactaaa gagtatggag gtatgtatta ctatgttaca gaaaataaca acatgcagtt 28936 ttatgaagtt actgtaacta atcccaccac gcctagaaca acaacaacca ccacaaagac 28996 tacacctgtt accactatgc agctcactac caataacatt tttgccatgc gtcagaaggc 29056 caacaatagc accagcattc aacccccccc acccagtgag gaaattccca aatccatgat 29116 tggcattatt gttgctgtag tggtgtgcat gttgatcatc gccttgtgca tggtgtacta 29176 tgccttctgc tacagaaagc acagactgaa cgacaagcta gaacacttac taagtgttga 29236 attttaattt ttttagaacc atg aag atc cta ggc ctt tta att ttt tct 29286 Met Lys Ile Leu Gly Leu Leu Ile Phe Ser 1010 1015 atc att acc tct gct cta tgc aat tct gac aat gag gac gtt act 29331 Ile Ile Thr Ser Ala Leu Cys Asn Ser Asp Asn Glu Asp Val Thr 1020 1025 1030 gtc gtt gtc gga tca aat tat aca ctg aaa ggt cca gcg aag ggt 29376 Val Val Val Gly Ser Asn Tyr Thr Leu Lys Gly Pro Ala Lys Gly 1035 1040 1045 atg ctt tcg tgg tat tgc tgg ttt gga act gac act gaa caa acc 29421 Met Leu Ser Trp Tyr Cys Trp Phe Gly Thr Asp Thr Glu Gln Thr 1050 1055 1060 gaa tta tgc aat ctt caa aat ggc aaa gtt cat aat tct aaa att 29466 Glu Leu Cys Asn Leu Gln Asn Gly Lys Val His Asn Ser Lys Ile 1065 1070 1075 tac aat tat ata tgc aat ggc act gat ttg ata ctc ctc aat atc 29511 Tyr Asn Tyr Ile Cys Asn Gly Thr Asp Leu Ile Leu Leu Asn Ile 1080 1085 1090 acg aaa tca tat gct ggc agt tat tca tgc cct gga gat gat gct 29556 Thr Lys Ser Tyr Ala Gly Ser Tyr Ser Cys Pro Gly Asp Asp Ala 1095 1100 1105 gac aat atg att ttt tat aaa ttg caa gtg gtt gat ccc act act 29601 Asp Asn Met Ile Phe Tyr Lys Leu Gln Val Val Asp Pro Thr Thr 1110 1115 1120 cca cct cca ccc acc aca act act cac acc aca cac aca gaa caa 29646 Pro Pro Pro Pro Thr Thr Thr Thr His Thr Thr His Thr Glu Gln 1125 1130 1135 acc aca gca gag gag gcg gca aag tta gct ttg cag gtc caa gac 29691 Thr Thr Ala Glu Glu Ala Ala Lys Leu Ala Leu Gln Val Gln Asp 1140 1145 1150 agt tca ttt gtt ggc att acc cct aca ccc gat cag cgg tgt ccg 29736 Ser Ser Phe Val Gly Ile Thr Pro Thr Pro Asp Gln Arg Cys Pro 1155 1160 1165 ggg ctg ctc gtc agc ggc att gtc ggt gtg ctt tcg gga tta gca 29781 Gly Leu Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly Leu Ala 1170 1175 1180 gtt ata atc atc tgc atg ttc att ttt gct tgc tgc tat aga agg 29826 Val Ile Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg 1185 1190 1195 ctt tac cga caa aaa tca gac cca ctg ctg aac ctc tat gtt 29868 Leu Tyr Arg Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 1200 1205 taattttttc cagagccatg aaggcagtta gcgctctagt tttttgttct ttgattggca 29928 ctgtttttag tgttagcttt ttaaaacaaa ttaatgttac tgagggggaa aatgtgacac 29988 tggtaggcgt agaaggtgct caaaatacca cctggacaaa ataccacctc gatgggtgga 30048 aagatatttg caattggagt gtcattactt acacatgtga gggagttaat ttgaccatag 30108 tcaatgccag ccaaaatcag aagggttgga ttaaagggca atctgttagt gttaccagtg 30168 aggggtacta tacccagcat actcttatct atgacattat agtcataccg ctgcctacgc 30228 ctagcccacc tagcactacc acacagacaa cccacactac acaaacaacc acatacagta 30288 catcaaatca gcctaccacc actacaacag cagaggttgc cagctcgtct ggggtccgag 30348 cggcattttt gatgttggcc ccatctagca gtcccactgc tagtaccaat gagcagacta 30408 ctgaattttt gtccactgtc gagagccaca ccacagctac ctcgagtgcc ttctctagca 30468 ccgccaatct ctcctcgctt tcctctacac caatcagtcc cgctactact actacccccg 30528 ctattcttcc cactcccctg aagcaaactg aggacagcgg catgcaatgg cagatcaccc 30588 tgctcattgt gatcgggttg gtcatcctag ccgtgttgct ctactacatc ttccgccgcc 30648 gcattcccaa cgcgcaccgc aagccggtct acaagcccat cattgtcggg cagccggagc 30708 cgcttcaggt ggaagggggt ctaaggaatc ttctcttctc ttttacagta tggtgattga 30768 actatgattc ctagacaatt cttgatcact attcttatct gcctcctcca agtctgtgcc 30828 accctcgctc tggtggccaa cgccagtcca gactgtattg ggcccttcgc ctcctacgtg 30888 ctctttgcct tcatcacctg catctgctgc tgtagcatag tctgcctgct tatcaccttc 30948 ttccagttca ttgactggat ctttgtgcgc atcgcctacc tgcgccacca cccccagtac 31008 cgcgaccagc gagtggcgca gctgctcagg ctcctctgat aagc atg cgg gct ctg 31064 Met Arg Ala Leu 1210 cta ctt ctc gcg ctt ctg ctg tta gtg ctc ccc cgt ccc gtt gac 31109 Leu Leu Leu Ala Leu Leu Leu Leu Val Leu Pro Arg Pro Val Asp 1215 1220 1225 ccc cgg ccc ccc act cag tcc ccc gag gag gtc cgc aaa tgc aaa 31154 Pro Arg Pro Pro Thr Gln Ser Pro Glu Glu Val Arg Lys Cys Lys 1230 1235 1240 ttc caa gaa ccc tgg aaa ttc ctc aaa tgc tac cgc caa aaa tca 31199 Phe Gln Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys Ser 1245 1250 1255 gac atg cat ccc agc tgg atc atg atc att ggg atc gtg aac att 31244 Asp Met His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile 1260 1265 1270 ctg gcc tgc acc ctc atc tcc ttt gtg att tac ccc tgc ttt gac 31289 Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Cys Phe Asp 1275 1280 1285 ttt ggt tgg aac tcg cca gag gcg ctc tat ctc ccg cct gaa cct 31334 Phe Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro 1290 1295 1300 gac aca cca cca cag caa cct cag gca cac gca cta cca cca cca 31379 Asp Thr Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Pro 1305 1310 1315 cag cct agg cca caa tac atg ccc ata tta gac tat gag gcc gag 31424 Gln Pro Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu 1320 1325 1330 cca cag cga ccc atg ctc ccc gct att agt tac ttc aat cta acc 31469 Pro Gln Arg Pro Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr 1335 1340 1345 ggc gga gat gac tgacccactg gccaacaaca acgtcaacga ccttctcctg 31521 Gly Gly Asp Asp 1350 gacatggacg gccgcgcctc ggagcagcga ctcgcccaac ttcgcattcg ccagcagcag 31581 gagagagccg tcaaggagct gcaggacggc atagccatcc accagtgcaa gaaaggcatc 31641 ttctgcctgg tgaaacaggc caagatctcc tacgaggtca cccagaccga ccatcgcctc 31701 tcctacgagc tcctgcagca gcgccagaag ttcacctgcc tggtcggagt caaccccatc 31761 gtcatcaccc agcagtcggg cgataccaag gggtgcatcc actgctcctg cgactccccc 31821 gactgcgtcc acactctgat caagaccctc tgcggcctcc gcgacctcct ccccatgaac 31881 taatcacccc cttatccagt gaaataaaga tcatattgat gattaaataa aaaaaataat 31941 catttgattt gaaataaaga tacaatcata ttgatgattt gagtttaata aaaataaaga 32001 atcacttact tgaaatctga taccaggtct ctgtccatgt tttctgccaa caccacttca 32061 ctcccctctt cccagctctg gtactgcagg ccccggcggg ctgcaaactt cctccacacc 32121 ctgaagggga tgtcaaattc ctcctgtccc tcaatcttca ttttatcttc tatcagatgt 32181 ccaaaaagcg cgtccgggtg gatgatgact tcgaccccgt ctacccctac gatgcagaca 32241 acgcaccgac cgtgcccttc atcaaccccc ccttcgtctc ttcagatgga ttccaagaga 32301 agcccctggg ggtgctgtcc ctgcgtctgg ccgatcccgt caccaccaag aacggggaaa 32361 tcaccctcaa gctgggagat ggggtggacc tcgactcctc gggaaaactc atctccaaca 32421 cggccaccaa ggccgccgcc cctctcagtt tttccaacaa caccatttcc cttaacatgg 32481 ataccccttt ttacaacaac aatggaaagt taggcatgaa agtcactgct ccactgaaga 32541 tactagacac agacttgcta aaaacacttg ttgtagctta tggacaaggt ttaggaacaa 32601 acaccactgg tgcccttgtt gcccaactag catccccact tgcttttgat agcaatagca 32661 aaattgccct taatttaggc aatggaccat tgaaagtgga tgcaaataga ctgaacatca 32721 attgcaatag aggactctat gttactacca caaaagatgc actggaagcc aatataagtt 32781 gggctaatgc tatgacattt ataggaaatg ccatgggtgt caatattgat acacaaaaag 32841 gcttgcaatt tggcaccact agtaccgtcg cagatgttaa aaacgcttac cccatacaaa 32901 tcaaacttgg agctggtctc acatttgaca gcacaggtgc aattgttgca tggaacaaag 32961 atgatgacaa gcttacacta tggaccacag ccgacccctc tccaaattgt cacatatatt 33021 ctgaaaagga tgctaagctt acactttgct tgacaaagtg tggcagtcag attctgggca 33081 ctgtttccct catagctgtt gatactggca gtttaaatcc cataacagga acagtaacca 33141 ctgctcttgt ctcacttaaa ttcgatgcaa atggagtttt gcaaagcagc tcaacactag 33201 actcagacta ttggaatttc agacagggag atgttacacc tgctgaagcc tatactaatg 33261 ctataggttt catgcccaat ctaaaagcat accctaaaaa cacaagtgga gctgcaaaaa 33321 gtcacattgt tgggaaagtg tacctacatg gggatacaga caaaccactg gacctcatta 33381 ttactttcaa tgaaacaagt gatgaatctt gcacttactg tattaacttt caatggcagt 33441 ggggggctga tcaatataaa aatgaaacac ttgccgtcag ttcattcacc ttttcctata 33501 ttgctaaaga ataaacccca ctctgtaccc catctctgtc tatggaaaaa actctgaaac 33561 acaaaataaa ataaagttca agtgttttat tgattcaaca gttttacagg attcgagcag 33621 ttatttttcc tccaccctcc caggacatgg aatacaccac cctctccccc cgcacagcct 33681 tgaacatctg aatgccattg gtgatggaca tgcttttggt ctccacgttc cacacagttt 33741 cagagcgagc cagtctcggg tcggtcaggg agatgaaacc ctccgggcac tcccgcatct 33801 gcacctcaca gctcaacagc tgaggattgt cctcggtggt cgggatcacg gttatctgga 33861 agaagcagaa gagcggcggt gggaatcata gtccgcgaac gggatcggcc ggtggtgtcg 33921 catcaggccc cgcagcagtc gctgtcgccg ccgctccgtc aagctgctgc tcagggggtc 33981 cgggtccagg gactccctca gcatgatgcc cacggccctc agcatcagtc gtctggtgcg 34041 gcgggcgcag cagcgcatgc ggatctcgct caggtcgctg cagtacgtgc aacacaggac 34101 caccaggttg ttcaacagtc catagttcaa cacgctccag ccgaaactca tcgcgggaag 34161 gatgctaccc acgtggccgt cgtaccagat cctcaggtaa atcaagtggc gccccctcca 34221 gaacacgctg cccatgtaca tgatctcctt gggcatgtgg cggttcacca cctcccggta 34281 ccacatcacc ctctggttga acatgcagcc ccggatgatc ctgcggaacc acagggccag 34341 caccgccccg cccgccatgc agcgaagaga ccccgggtcc cgacaatggc aatggaggac 34401 ccaccgctcg tacccgtgga tcatctggga gctgaacaag tctatgttgg cacagcacag 34461 gcatatgctc atgcatctct tcagcactct cagctcctcg ggggtcaaaa ccatatccca 34521 gggcacgggg aactcttgca ggacagcgaa ccccgcagaa cagggcaatc ctcgcacata 34581 acttacattg tgcatggaca gggtatcgca atcaggcagc accgggtgat cctccaccag 34641 agaagcgcgg gtctcggtct cctca cag cgt ggt aag ggg gcc ggc cga tac 34693 Gln Arg Gly Lys Gly Ala Gly Arg Tyr 1355 1360 ggg tga tgg cgg gac gcg gct gat cgt gtt cgc gac cgt gtc atg 34738 Gly Trp Arg Asp Ala Ala Asp Arg Val Arg Asp Arg Val Met 1365 1370 1375 atg cag ttg ctt tcg gac att ttc gta ctt gct gta gca gaa cct 34783 Met Gln Leu Leu Ser Asp Ile Phe Val Leu Ala Val Ala Glu Pro 1380 1385 1390 ggt ccg ggc gct gca cac cga tcg ccg gcg gcg gtc ccg gcg ctt 34828 Gly Pro Gly Ala Ala His Arg Ser Pro Ala Ala Val Pro Ala Leu 1395 1400 1405 gga acg ctc ggt gtt gaa gtt gta aaa cag cca ctc tct cag acc 34873 Gly Thr Leu Gly Val Glu Val Val Lys Gln Pro Leu Ser Gln Thr 1410 1415 1420 gtg cag cag atc tag ggc ctc agg agt gat gaa gat ccc atc atg 34918 Val Gln Gln Ile Gly Leu Arg Ser Asp Glu Asp Pro Ile Met 1425 1430 cct gat ggc tct aat cac atc gac cac cgt gga atg ggc cag acc 34963 Pro Asp Gly Ser Asn His Ile Asp His Arg Gly Met Gly Gln Thr 1435 1440 1445 cag cca gat gat gca att ttg ttg ggt ttc ggt gac ggc ggg gga 35008 Gln Pro Asp Asp Ala Ile Leu Leu Gly Phe Gly Asp Gly Gly Gly 1450 1455 1460 ggg aag aac agg aag aac cat gattaacttt taatccaaac ggtctcggag 35059 Gly Lys Asn Arg Lys Asn His 1465 1470 cacttcaaaa tgaagatcgc ggagatggca cctctcgccc ccgctgtgtt ggtggaaaat 35119 aacagccagg tcaaaggtga tacggttctc gagatgttcc acggtggctt ccagcaaagc 35179 ctccacgcgc acatccagaa acaagacaat agcgaaagcg ggagggttct ctaattcctc 35239 aatcatcatg ttacactcct gcaccatccc cagataattt tcatttttcc agccttgaat 35299 gattcgaact agttcctgag gtaaatccaa gccagccatg ataaagagct cgcgcagagc 35359 gccctccacc ggcattctta agcacaccct cataattcca agatattctg ctcctggttc 35419 acctgcagca gattgacaag cggaatatca aaatctctgc cgcgatccct aagctcctcc 35479 ctcagcaata actgtaagta ctctttcata tcctctccga aatttttagc cataggaccg 35539 ccaggaatga gattaggaca agccacatta cagataaacc gaagtccccc ccagtgagca 35599 ttgccaaatg taagattgaa ataagcatgc tggctagacc cggtgatatc ttccagataa 35659 ctggacagaa aatcgcccag gcaattttta agaaaatcaa caaaagaaaa atcttccagg 35719 tgcacgttta gggcctcggg aacaacgatg gagtaagtgc aaggggtgcg ttccagcatg 35779 gttagttagc tgatctgtaa aaaaacaaaa aataaaacat taaaccatgc tagcctggcg 35839 aacaggtggg taaatcgttc tctccagcac caggcaggcc acggggtctc cggcgcgacc 35899 ctcgtaaaaa ttgtcgctat gattgaaaac catcacagag agacgttccc ggtggccggc 35959 gtgaatgatt cgacaagatg aatacacccc cggaacattg gcgtccgcga gtgaaaaaaa 36019 gcggccgagg aagcaataag gcactacaat gctcagtctc aagtccagca aagcgatgcc 36079 atgcggatga agcacaaaat tctcaggtgc gtacaaaatg taattactcc cctcctgcac 36139 aggcagcaaa gccccagatc cctccagata cacatacaaa gcctcagcgt ccatagctta 36199 ccgagcagca gcacacaaca ggcgcaagag tcagagaaag gctgagctct aacctgtccc 36259 ccgctctctg ctcaatatat agcccagatc tacactgacg taaaggccaa agtctaaaaa 36319 tacccgccaa ataatcacac acgcccagca cacgcccaga aaccggtgac acactcaaaa 36379 aaatacgcgc acttcctcaa acgcccaaac tgccgtcatt tccgggttcc cacgctacgt 36439 catcagaatt cgactttcaa atccgtcgac cgttaaacac gtcactcgcc ccgcccctaa 36499 cggtcgccct cctctcggcc aatcacagcc ccgcatcccc aaattcaaac gcctcatttg 36559 catattaacg cgcacaaaaa gtttgaggta tattattgat gatgatcgtt taaactatgc 36619 ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg catcaggcgc tcttccgctt 36679 cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact 36739 caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag 36799 caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata 36859 ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc 36919 cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg 36979 ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc 37039 tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg 37099 gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc 37159 ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga 37219 ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg 37279 gctacactag aaggacagta tttggtatct gcgctctgct gaagccagtt accttcggaa 37339 aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg 37399 tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt 37459 ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat 37519 tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct 37579 aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta 37639 tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa 37699 ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac 37759 gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa 37819 gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag 37879 taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctgca ggcatcgtgg 37939 tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag 37999 ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg 38059 tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc 38119 ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat 38179 tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaaca cgggataata 38239 ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa 38299 aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca 38359 actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc 38419 aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc 38479 tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg 38539 aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac 38599 ctgacgtcta agaaaccatt attatcatga cattaaccta taaaaatagg cgtatcacga 38659 ggccctttcg tcttcaagaa ttgtttaaac tac 38692 <210> 280 <211> 798 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 280 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ala 1 5 10 15 Ala Asp Glu Asn Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro 20 25 30 Pro Ser Pro Thr Ser Asp Ala Ala Ala Pro Asp Met Gln Glu Met Glu 35 40 45 Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu 50 55 60 Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln Glu 65 70 75 80 Gln Pro Glu Gln Glu Ala Glu Ser Glu Gln Ser Gln Ala Gly Leu Glu 85 90 95 His Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu Ile Lys His Leu 100 105 110 Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Ala Glu 115 120 125 Val Pro Leu Ser Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg Asn Leu 130 135 140 Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys Glu 145 150 155 160 Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu Ala 165 170 175 Leu Ala Thr Tyr His Leu Phe Phe Lys Asn Gln Arg Ile Pro Val Ser 180 185 190 Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Leu Asn Leu Gly Pro 195 200 205 Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro Lys Ile 210 215 220 Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu Gln 225 230 235 240 Gly Ser Gly Glu Glu His Glu His His Ser Ala Leu Val Glu Leu Glu 245 250 255 Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu Thr 260 265 270 His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser Ala 275 280 285 Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu Glu 290 295 300 Glu Met Gln Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val Val Ser 305 310 315 320 Asp Glu Gln Leu Ala Arg Trp Leu Gly Thr Ser Ser Thr Pro Gln Ser 325 330 335 Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr Val 340 345 350 Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu Arg 355 360 365 Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val Arg 370 375 380 Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr 385 390 395 400 Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr 405 410 415 Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr 420 425 430 Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln Gln 435 440 445 Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys 450 455 460 Asn Leu Lys Ala Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser 465 470 475 480 Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg 485 490 495 Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg 500 505 510 Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala 515 520 525 Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro 530 535 540 Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala Tyr 545 550 555 560 His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu Cys 565 570 575 His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys Asn 580 585 590 Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln 595 600 605 Gly Pro Gly Glu Glu Gly Lys Gly Gly Leu Lys Leu Thr Pro Gly Leu 610 615 620 Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr His Pro 625 630 635 640 Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys Ala Glu 645 650 655 Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala Gln Leu Gln 660 665 670 Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly His Gly 675 680 685 Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro Ser Phe Pro 690 695 700 Gln Asp Ala Gln Arg Lys Gln Gln Glu Ala Glu Ser Gly Ala Ala Ala 705 710 715 720 Ala Ala Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly 725 730 735 Gly Gly Asp Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln Pro 740 745 750 Ala Arg Gln Ser Gly Arg Arg Gly Gly Gly Gly Arg Gly Arg Ser Ser 755 760 765 Arg Arg Gln Thr Val Val Leu Gly Gly Glu Ser Lys Gln His Gly Tyr 770 775 780 His Leu Arg Ser Gly Ser Gly Ser Arg Arg Pro Gly Pro Gln 785 790 795 <210> 281 <211> 207 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 281 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Pro Cys Val Pro Glu Ser Ile Asn Gln 20 25 30 Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys 35 40 45 Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala 50 55 60 Val Val Asn His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala 65 70 75 80 Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro 85 90 95 Phe Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro Cys His His Thr 100 105 110 Phe His Leu Ile Pro Asn Thr Thr Ala Ser Leu Pro Ala Thr Asn Asn 115 120 125 Gln Thr Thr His Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser Asn 130 135 140 Thr Thr Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile Tyr 145 150 155 160 Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val Val 165 170 175 Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser Tyr 180 185 190 Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 195 200 205 <210> 282 <211> 204 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 282 Met Lys Ile Leu Gly Leu Leu Ile Phe Ser Ile Ile Thr Ser Ala Leu 1 5 10 15 Cys Asn Ser Asp Asn Glu Asp Val Thr Val Val Val Gly Ser Asn Tyr 20 25 30 Thr Leu Lys Gly Pro Ala Lys Gly Met Leu Ser Trp Tyr Cys Trp Phe 35 40 45 Gly Thr Asp Thr Glu Gln Thr Glu Leu Cys Asn Leu Gln Asn Gly Lys 50 55 60 Val His Asn Ser Lys Ile Tyr Asn Tyr Ile Cys Asn Gly Thr Asp Leu 65 70 75 80 Ile Leu Leu Asn Ile Thr Lys Ser Tyr Ala Gly Ser Tyr Ser Cys Pro 85 90 95 Gly Asp Asp Ala Asp Asn Met Ile Phe Tyr Lys Leu Gln Val Val Asp 100 105 110 Pro Thr Thr Pro Pro Pro Pro Thr Thr Thr Thr His Thr Thr His Thr 115 120 125 Glu Gln Thr Thr Ala Glu Glu Ala Ala Lys Leu Ala Leu Gln Val Gln 130 135 140 Asp Ser Ser Phe Val Gly Ile Thr Pro Thr Pro Asp Gln Arg Cys Pro 145 150 155 160 Gly Leu Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly Leu Ala Val 165 170 175 Ile Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr 180 185 190 Arg Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 195 200 <210> 283 <211> 143 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 283 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu Val Leu Pro Arg 1 5 10 15 Pro Val Asp Pro Arg Pro Pro Thr Gln Ser Pro Glu Glu Val Arg Lys 20 25 30 Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys 35 40 45 Ser Asp Met His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile 50 55 60 Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Cys Phe Asp Phe 65 70 75 80 Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr 85 90 95 Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Pro Gln Pro Arg 100 105 110 Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg Pro 115 120 125 Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 130 135 140 <210> 284 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 284 Gln Arg Gly Lys Gly Ala Gly Arg Tyr Gly 1 5 10 <210> 285 <211> 62 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 285 Trp Arg Asp Ala Ala Asp Arg Val Arg Asp Arg Val Met Met Gln Leu 1 5 10 15 Leu Ser Asp Ile Phe Val Leu Ala Val Ala Glu Pro Gly Pro Gly Ala 20 25 30 Ala His Arg Ser Pro Ala Ala Val Pro Ala Leu Gly Thr Leu Gly Val 35 40 45 Glu Val Val Lys Gln Pro Leu Ser Gln Thr Val Gln Gln Ile 50 55 60 <210> 286 <211> 47 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 286 Gly Leu Arg Ser Asp Glu Asp Pro Ile Met Pro Asp Gly Ser Asn His 1 5 10 15 Ile Asp His Arg Gly Met Gly Gln Thr Gln Pro Asp Asp Ala Ile Leu 20 25 30 Leu Gly Phe Gly Asp Gly Gly Gly Gly Lys Asn Arg Lys Asn His 35 40 45 <210> 287 <211> 36781 <212> DNA <213> Artificial Sequence <220> <223> p2875 - E1 deleted molecular clone, based on Simian Adenovirus A1337 <220> <221> repeat_region <222> (1)..(123) <223> ITR <220> <221> polyA_signal <222> (749)..(951) <220> <221> polyA_signal <222> (749)..(951) <223> BGH-PolyA (bovine growth hormone (bGH) polyadenylation signal) <220> <221> misc_feature <222> (2030)..(3651) <223> IVa2 complement (2030..3360, 3640..3651) <220> <221> misc_feature <222> (3640)..(11891) <223> pol complement (3640..6705, 11883..11891) <220> <221> misc_feature <222> (6513)..(11891) <223> pTP complement (6513..8441, 11883..11891) <220> <221> CDS <222> (8878)..(10059) <223> 52K <220> <221> CDS <222> (10086)..(11852) <223> pIIIa <220> <221> CDS <222> (11936)..(13531) <223> penton <220> <221> CDS <222> (13538)..(14116) <223> pVII <220> <221> CDS <222> (14161)..(15186) <223> V <220> <221> CDS <222> (15213)..(15443) <223> pX <220> <221> CDS <222> (15478)..(16254) <223> pVI <220> <221> CDS <222> (16360)..(19152) <223> hexon <220> <221> CDS <222> (19168)..(19797) <223> protease <220> <221> CDS <222> (19877)..(21412) <223> DBP Complement (19877..21412) <220> <221> CDS <222> (21441)..(23843) <223> 100K <220> <221> CDS <222> (24465)..(25145) <223> pVIII <220> <221> CDS <222> (25149)..(25466) <223> E3\12.5K <220> <221> CDS <222> (26043)..(26570) <223> E3\gp19K <220> <221> CDS <222> (26609)..(27349) <223> E3\CR1-beta <220> <221> CDS <222> (28011)..(28883) <223> E3\CR1-delta <220> <221> CDS <222> (29170)..(29616) <223> E3\RID-beta <220> <221> CDS <222> (30125)..(31594) <223> fiber <220> <221> misc_feature <222> (31690)..(33017) <223> E4 orf 6/7 Complement (31690..31940, 32664..33017) <220> <221> CDS <222> (31941)..(32837) <223> E4\orf6 (complement 31941..32837) <220> <221> CDS <222> (33120)..(33470) <223> E4\orf3 (complement 33120..33470) <220> <221> CDS <222> (33909)..(34280) <223> E4\orf1 (complement 33909..34280) <220> <221> repeat_region <222> (34558)..(34680) <223> ITR (complement 34558..34680) <220> <221> misc_feature <222> (34926)..(34932) <223> pMB1\ORI: low copy number <220> <221> misc_feature <222> (34935)..(35523) <223> pMB1\ORI <220> <221> rep_origin <222> (34936)..(34936) <223> ORI <220> <221> CDS <222> (35694)..(36557) <223> AP(R) [Note: E-286] Complement (35694..36557) <400> 287 caataatata cctcaaactt tttgtgcgcg ttaatatgca aatgaggcgt ttgaatttgg 60 gaagggagga aggtgattgg ccgagagaag ggcgaccgtt aggggcgggg cgagtgacgt 120 tttgatgacg tggccgcgag gaggagccag tttgcaagtt ctcgtgggaa aagtgacgtc 180 aaacgaggtg tggtttgaac acggaaatac tcaattttcc cgcgctctct gacaggaaat 240 gaggtgtttt tgggcggatg caagttaaaa cgggccattt tcgcgcgaaa actgaatgag 300 gaagtgaaaa tctgagtaat ttcgcgttta tggcagggag gagtatttgc cgagggccga 360 gtagactttg accgattacg tgggggtttc gattaccgtg tttttcacct aaatttccgc 420 gtacggtgtc aaagtccggt gtttttacat catttccccg aaaagtgcca cctgacgtaa 480 ctataacggt cctaaggtag cgaaagctca gatctcccga tcccctatgg tgcactctca 540 gtacaatctg ctctgatgcc gcatagttaa gccagtatct gctccctgct tgtgtgttgg 600 aggtcgctga gtagtgcgcg agcaaaattt aagctacaac aaggcaaggc ttgaccgaca 660 attgcatgaa gaatctgctt agggttaggc gttttgcgct gcttcgcgat gtacgggcca 720 gatatacgcg gtacgaaacc gctgatcagc ctcgactgtg ccttctagtt gccagccatc 780 tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct 840 ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg 900 gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg 960 ggatgcggtg ggctctatgg cttctgaggc ggaaagaacc agcagatctg cagatctgaa 1020 ttcatctatg tcgggtgcgg agaaagaggt aatgaaatgg cacatatgct ggccaccgtg 1080 catgtggctt cccatgcccg caagccctgg cccgagttcg agcacaatgt catgaccagg 1140 tgcaatatgc atctggggtc tcgccgaggc atgttcatgc cctaccagtg caacctgaat 1200 tatgtgaagg tgctgctgga gcccgatgcc atgtccagag tgagcctgac gggggtgttt 1260 gacatgaatg tggaggtgtg gaagattctg agatatgatg aatccaagac caggtgccga 1320 gcctgcgagt gcggagggaa gcatgccagg ttccagcccg tgtgtgtgga tgtgacggag 1380 gacctgcgac ccgatcattt ggtgttgtcc tgcaccggga cggagttcgg ttccagcggg 1440 gaagaatctg actagagtga gtagtgttct ggggcggggg aggacctgca tgagggccag 1500 aatgattgaa atctgtgctt ttctgtgtgt tgcagcagca tgagcggaag cggctccttt 1560 gagggagggg tattcagccc ttatctgacg gggcgtctcc cctcctgggc gggagtgcgt 1620 cagaatgtga tgggatccac ggtggacggc cggcccgtgc agcccgcgaa ctcttcaacc 1680 ctgacctatg caaccctgag ctcttcgtcg gtggacgcag ctgccgccgc agctgctgca 1740 tctgccgcca gcgccgtgcg cggaatggcc atgggcgccg gctactacgg cactctggtg 1800 gccaactcga gttccaccaa taatcccgcc agcctgaacg aggagaagct gctgctgctg 1860 atggcccagc tcgaggcctt gacccagcgc ctgggcgagc tgacccagca ggtggctcag 1920 ctgcaggagc agacgcgggc cgcggttgcc acggtgaaat ccaaataaaa aatgaatcaa 1980 taaataaacg gagacggttg ttgattttaa cacagagtct gaatctttat ttgatttttc 2040 gcgcgcggta ggccctggac caccggtctc gatcattgag cactcggtgg atcttttcca 2100 ggacccggta gaggtgggct tggatgttga ggtacatggg catgagcccg tcccgggggt 2160 ggaggtagct ccattgcagg gcctcgtgct cgggggtggt gttgtaaatc acccagtcat 2220 agcaggggcg cagggcatgg tgttgcacaa tatctttgag gaggagactg atggccacgg 2280 gcagcccttt ggtgtaggtg tttacaaatc tgttgagctg ggagggatgc atgcgggggg 2340 agatgaggtg catcttggcc tggatcttga gattggcgat gttaccgccc agatcccgcc 2400 tggggttcat gttgtgcagg accaccagca cggtgtatcc ggtgcacttg gggaatttat 2460 catgcaactt ggaagggaag gcgtgaaaga atttggcgac gcccttgtgc ccgcccaggt 2520 tttccatgca ctcatccatg atgatggcga tggggccgtg ggcggcggcc tgggcaaaaa 2580 cgtttcgggg gtcggacaca tcatagttgt ggtcctgggt gagatcatca taggccattt 2640 taatgaattt ggggcggagg gtgccggact gggggacaaa ggtaccctcg atcccggggg 2700 cgtagttccc ctcacagatc tgcatctccc aggctttgag ctcggagggg gggatcatgt 2760 ccacctgcgg ggcgataaag aacacggttt ccggggcggg agagatgagc tgggccgaaa 2820 gcaagttccg gagcagctgg gacttgccgc agccggtggg gccgtagatg accccgatga 2880 ccggttgcag gtggtagttg agggagagac agctgccgtc ctcccggagg aggggggcca 2940 cctcgttcat catctcgcgc acgtgcatgt tctcgcgcac cagttccgcc aggaggcgct 3000 ctccccccag ggataggagc tcctggagcg aggcgaagtt tttcagcggc ttgagtccgt 3060 cggccatggg cattttggag agggtctgtt gcaagagttc caagcggtcc cagagctcgg 3120 tgatgtgctc tacggcatct cgatccagca gacctcctcg tttcgcgggt tggggcggct 3180 gcgggagtag ggcaccagac gatgggcgtc cagcgcagcc agggtccggt ccttccaggg 3240 tcgcagcgtc cgcgtcaggg tggtctccgt cacggtgaag gggtgcgcgc cgggctgggc 3300 gcttgcgagg gtgcgcttca ggctcatccg gctggtcgaa aaccgctccc gatcggcgcc 3360 ctgcgcgtcg gccaggtagc aattgaccat gagttcgtaa ttgagcgcct cggccgcgtg 3420 acctttggcg cggagcttac ctttggaagt ctgcccgcag gtgggacaga ggagggactt 3480 gagggcgtag agcttggggg cgaggaagac ggactcgggg gcgtaggcgt ccgcgccgca 3540 gtgggcgcag acggtctcgc actccacgag ccaggtgagg tcgggctggt cggggtcaaa 3600 aaccagtttc ccgccgttct ttttgatgcg tttcttacct ttggtctcca tgagctcgtg 3660 tccccgctgg gtgacaaaga ggctgtccgt gtccccgtag accgacttta tgggccggtc 3720 ctcgagcggt gtgccgcggt cctcctcgta gaggaacccc gcccactccg agacgaaagc 3780 ccgggtccag gccagcacga aggaggccac gtgggacggg tagcggtcgt tgtccaccag 3840 cgggtccacc ttctccaggg tatgcaaaca catgtccccc tcgtccacat ccaggaaggt 3900 gattggcttg taagtgtagg ccacgtgacc gggggtccca gccggggggg tataaaaggg 3960 ggcgggcccc tgctcgtcct cactgtcttc cggatcgctg tccaggagcg ccagctgttg 4020 gggtaggtat tccctctcga aggcgggcat gacctcggca ctcaggttgt cagtttctag 4080 aaacgaggag gatttgatat tgacggtgcc ggcggagatg cctttcaaga gcccctcgtc 4140 catctggtca gaaaagacga tctttttgtt gtcgagtttg gtggcgaagg agccgtagag 4200 ggcattggag aggagcttgg cgatagagcg catggtctgg tttttttcct tgtcggcgcg 4260 ctccttggcc gcgatgttga gctgcacgta ctcgcgcgcc acgcacttcc attcggggaa 4320 gacggtggtc agctcgtcgg gcacgattct gacttgccag ccccggttat gcagggtgat 4380 gaggtccaca ctggtgccca cctcgccgcg caggggctcg ttggtccagc agagtcgacc 4440 gcccttgcgc gagcagaagg ggggcagggg gtccagcatg acctcgtcgg gggggtcggc 4500 atcgatggtg aagatgcctg gcaggagatc ggggtcgaag tagctgatgg aagtggccag 4560 atcgtccagg gcagcttgcc attcgcgcac ggccagcgcg cgctcgtagg gactgagggg 4620 cgtgccccaa ggcatggggt gtgtgagcgc ggaggcgtac atgccgcaga tgtcgtagac 4680 gtagaggggc tcctcgagga tgccgatgta ggtggggtaa cagcgccccc cgcggatgct 4740 ggcgcgcacg tagtcataca gctcatgcga gggggcgagg agccccgggc ccaggttggt 4800 gcgactgggc ttttcggcgc ggtagacgat ctggcgaaag atggcatgcg agttggagga 4860 gatggtgggc ctttggaaga tgttgaagtg ggcgtggggc agaccgaccg agtcgcggat 4920 gaagtgggcg taggagtctt gcagtttggc gacgagctcg gcggtgacga ggacgtccag 4980 agcgcagtag tcgagggtct cctggatgat gtcatacttg agctggccct tttgtttcca 5040 cagctcgcgg ttgagaagga actcttcgcg gtccttccag tactcttcga gggggaaccc 5100 gtcctgatct gcacggtaag agcctagcat gtagaactgg ttgacggcct tgtaggcgca 5160 gcagcccttc tccacgggga gggcgtaggc ctgggcggcc ttgcgcaggg aggtgtgcgt 5220 gagggcgaag gtgtccctga ccatgacctt gaggaactgg tgcttgaaat cgatatcgtc 5280 gcagcccccc tgctcccaga gctggaagtc cgtgcgcttc ttgtaggcgg ggttgggcaa 5340 agcgaaagta acatcgttga aaaggatctt gcccgcgcgg ggcataaagt tgcgagtgat 5400 gcggaaaggc tggggcacct cggcccggtt gttgatgacc tgggcggcga gcacgatctc 5460 gtcgaaaccg ttgatgttgt ggcccacgat gtagagttcc acgaatcgcg ggcggccctt 5520 gacgtggggc agcttcttga gctcctcgta ggtgagctcg tcggggtcgc tgagaccgtg 5580 ctgctcgagc gcccagtcgg cgagatgggg gttggcgcgg aggaaggaag tccagagatc 5640 cacggccagg gcggtttgca gacggtcccg gtactgacgg aactgctgcc cgacggccat 5700 tttttcgggg gtgacgcagt agaaggtgcg ggggtccccg tgccagcggt cccatttgag 5760 ctggagggcg agatcgaggg cgagctcgac gaggcggtcg tccccggaga gtttcatgac 5820 cagcatgaag gggacgagct gcttgccgaa ggaccccatc caggtgtagg tttccacatc 5880 gtaggtgagg aagagccttt cggtgcgagg atgcgagccg atggggaaga actggatctc 5940 ctgccaccaa ttggaggaat ggctgttgat gtgatggaag tagaaatgcc gacggcgcgc 6000 cgaacactcg tgcttgtgtt tatacaagcg gccacagtgc tcgcaacgct gcacgggatg 6060 cacgtgctgc acgagctgta cctgagttcc tttgacgagg aatttcagtg ggaagtggag 6120 tcgtggcgcc tgcatctcgt gctgtactac gtcgtggtgg tcggcctggc cctcttctgc 6180 ctcgatggtg gtcatgctga cgagcccgcg cgggaggcag gtccagacct cggcgcgagc 6240 gggtcggaga gcgaggacga gggcgcgcag gccggagctg tccagggtcc tgagacgctg 6300 cggagtcagg tcagtgggca gcggcggcgc gcggttgact tgcaggagtt tttccagggc 6360 gcgcgggagg tccagatggt acttgatctc caccgcgccg ttggtggcga cgtcgatggc 6420 ttgcagggtc ccgtgcccct ggggtgtgac caccgtcccc cgtttcttct tgggcggctg 6480 gggcgacggg ggcggtgcct cttccatggt tagaagcggc ggcgaggacg cgcgccgggc 6540 ggcagaggcg gctcggggcc cggaggcagg ggcggcaggg gcacgtcggc gccgcgcgcg 6600 ggtaggttct ggtactgcgc ccggagaaga ctggcgtgag cgacgacgcg acggttgacg 6660 tcctggatct gacgcctctg ggtgaaggcc acgggacccg tgagtttgaa cctgaaagag 6720 agttcgacag aatcaatctc ggtatcgttg acggcggcct gccgcaggat ctcttgcacg 6780 tcgcccgagt tgtcctggta ggcgatctcg gtcatgaact gctcgatctc ctcctcctga 6840 aggtctccgc ggccggcgcg ctccacggtg gccgcgaggt cgttggagat gcggcccatg 6900 agctgcgaga aggcgttcat gcccgcctcg ttccagacgc ggctgtagac cacgacgccc 6960 tcgggatcgc gggcgcgcat gaccacctgg gcgaggttga gctccacgtg gcgcgtgaag 7020 accgcgtagt tgcagaggcg ctggtagagg tagttgagcg tggtggcgat gtgctcggtg 7080 acgaagaaat acatgatcca gcggcggagc ggcatctcgc tgacgtcgcc cagcgcctcc 7140 aagcgttcca tggcctcgta aaagtccacg gcgaagttga aaaactggga gttgcgcgcc 7200 gagacggtca actcctcctc cagaagacgg atgagctcgg cgatggtggc gcgcacctcg 7260 cgctcgaagg cccccgggag ttcctcctct tccatctcct cttcttcctc ctccactaac 7320 atctcttcta cttcctcctc aggcggtggt ggcgggggag ggggcctgcg tcgccggcgg 7380 cgcacgggca gacggtcgat gaagcgctcg atggtctcgc cgcgccggcg tcgcatggtc 7440 tcggtgacgg cgcgcccgtc ctcgcggggc cgcagcgtga agacgccgcc gcgcatctcc 7500 aggtggccgg gggggtcccc gttgggcagg gagagggcgc tgacgatgca tcttatcaat 7560 tgccccgtag ggactccgcg caaggacctg agcgtctcga gatccacggg atctgaaaac 7620 cgttgaacga aggcttcgag ccagtcgcag tcgcaaggta ggctgagcac ggtttcttct 7680 ggcgggtcat gttggggagc ggggcgggcg atgctgctgg tgatgaagtt gaaataggcg 7740 gttctgagac ggcggatggt ggcgaggagc accaggtctt tgggcccggc ttgctggatg 7800 cgcagacggt cggccatgcc ccaggcgtgg tcctgacacc tggccaggtc cttgtagtag 7860 tcctgcatga gccgctccac gggcacctcc tcctcgcccg cgcggccgtg catgcgcgtg 7920 agcccgaagc cgcgctgggg ctggacgagc gccaggtcgg cgacgacgcg ctcggcgagg 7980 atggcctgct ggatctgggt gagggtggtc tggaagtcgt caaagtcgac gaagcggtgg 8040 taggctccgg tgttgatggt gtaggagcag ttggccatga cggaccagtt gacggtctgg 8100 tggcccggac gcacgagctc gtggtacttg aggcgcgagt aggcgcgcgt gtcgaagatg 8160 tagtcgttgc aggtgcgcac caggtactgg tagccgatga ggaagtgcgg cggcggctgg 8220 cggtagagcg gccatcgctc ggtggcgggg gcgccgggcg cgaggtcctc gagcatggtg 8280 cggtggtagc cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg 8340 cgcgggaact cgcggacgcg gttccagatg ttgcgcagcg gcaggaagta gttcatggtg 8400 ggcacggtct ggcccgtgag gcgcgcgcag tcgtggatgc tctatacggg caaaaacgaa 8460 agcggtcagc ggctcgactc cgtggcctgg aggctaagcg aacgggttgg gctgcgcgtg 8520 taccccggtt cgaatctcga atcaggctgg agccgcagct aacgtggtac tggcactccc 8580 gtctcgaccc aagcctgcac caaccctcca ggatacggag gcgggtcgtt ttgcaacttt 8640 ttttcggagg ccggaaatga agactagtaa gcgcggaaag cggccgaccg cgatggctcg 8700 ctgccgtagt ctggagaaga atcgccaggg ttgcgttgcg gtgtgccccg gttcgaggcc 8760 ggccggattc cgcggctaac gagggcgtgg ctgccccgtc gtttccaaga ccccctagcc 8820 agccgacttc tccagttacg gagcgagccc ctcttttgtt ttgtttgttt ttgccag 8877 atg cat ccc gta ctg cgg cag atg cgc ccc cac cac cct cca ccg caa 8925 Met His Pro Val Leu Arg Gln Met Arg Pro His His Pro Pro Pro Gln 1 5 10 15 caa cag ccc cct cca cag ccg gcg ctt ctg ccc ccg ccc cag cag cag 8973 Gln Gln Pro Pro Pro Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln 20 25 30 cag caa ctt cca gcc acg acc gcc gcg gcc gcc gtg agc ggg gct gga 9021 Gln Gln Leu Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala Gly 35 40 45 cag act tct cag tat gac ctg gcc ttg gaa gag ggc gag ggg ctg gcg 9069 Gln Thr Ser Gln Tyr Asp Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala 50 55 60 cgc ctg ggg gcg tcg tcg ccg gag cgg cac ccg cgc gtg cag atg aaa 9117 Arg Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys 65 70 75 80 agg gac gct cgc gag gcc tac gtg ccc aag cag aac ctg ttc aga gac 9165 Arg Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp 85 90 95 agg agc ggc gag gag ccc gag gag atg cgc gcg gcc cgg ttc cac gcg 9213 Arg Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ala Arg Phe His Ala 100 105 110 ggg cgg gag ctg cgg cgc ggc ctg gac cga aag agg gtg ctg agg gac 9261 Gly Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp 115 120 125 gag gat ttc gag gcg gac gag ctg acg ggg atc agc ccc gcg cgc gcg 9309 Glu Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala 130 135 140 cac gtg gcc gcg gcc aac ctg gtc acg gcg tac gag cag acc gtg aag 9357 His Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys 145 150 155 160 gag gag agc aac ttc caa aaa tcc ttc aac aac cac gtg cgc acc ctg 9405 Glu Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu 165 170 175 atc gcg cgc gag gag gtg acc ctg ggc ctg atg cac ctg tgg gac ctg 9453 Ile Ala Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu 180 185 190 ctg gag gcc atc gtg cag aac ccc acc agc aag ccg ctg acg gcg cag 9501 Leu Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln 195 200 205 ctg ttc ctg gtg gtg cag cat agt cgg gac aac gag gcg ttc agg gag 9549 Leu Phe Leu Val Val Gln His Ser Arg Asp Asn Glu Ala Phe Arg Glu 210 215 220 gcg ctg ctg aat atc acc gag ccc gag ggc cgc tgg ctc ctg gac ctg 9597 Ala Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu 225 230 235 240 gtg aac att ctg cag agc atc gtg gtg cag gag cgc ggg ctg ccg ctg 9645 Val Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu 245 250 255 tcc gag aag ctg gcg gcc atc aac ttc tcg gtg ctg agt ctg ggc aag 9693 Ser Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys 260 265 270 tac tac gct agg aag atc tac aag acc ccg tac gtg ccc ata gac aag 9741 Tyr Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys 275 280 285 gag gtg aag atc gac ggg ttt tac atg cgc atg acc ctg aaa gtg ctg 9789 Glu Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu 290 295 300 acc ctg agc gac gat ctg ggg gtg tac cgc aac gac agg atg cac cgc 9837 Thr Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg 305 310 315 320 gcg gtg agc gcc agc agg cgg cgc gag ctg agc gac cag gag ctg atg 9885 Ala Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met 325 330 335 cat agt ctg cag cgg gcc ctg acc ggg gcc ggg acc gag ggg gag agc 9933 His Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser 340 345 350 tac ttt gac atg ggc gcg gac ctg cac tgg cag ccc agc cgc cgg gcc 9981 Tyr Phe Asp Met Gly Ala Asp Leu His Trp Gln Pro Ser Arg Arg Ala 355 360 365 ttg gag gcg gca ggc ggt ccc ccc tac ata gaa gag gtg gac gat gag 10029 Leu Glu Ala Ala Gly Gly Pro Pro Tyr Ile Glu Glu Val Asp Asp Glu 370 375 380 gtg gac gag gag ggc gag tac ctg gaa gac tgatggcgcg accgtatttt 10079 Val Asp Glu Glu Gly Glu Tyr Leu Glu Asp 385 390 tgctag atg caa caa cag cca cct cct gat ccc gcg atg cgg gcg gcg 10127 Met Gln Gln Gln Pro Pro Pro Asp Pro Ala Met Arg Ala Ala 395 400 405 ctg cag agc cag ccg tcc ggc att aac tcc tcg gac gat tgg acc cag 10175 Leu Gln Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln 410 415 420 gcc atg caa cgc atc atg gcg ctg acg acc cgc aac ccc gaa gcc ttt 10223 Ala Met Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe 425 430 435 440 aga cag cag ccc cag gcc aac cgg ctc tcg gcc atc ctg gag gcc gtg 10271 Arg Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val 445 450 455 gtg ccc tcg cgc tcc aac ccc acg cac gag aag gtc ctg gcc atc gtg 10319 Val Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val 460 465 470 aac gcg ctg gtg gag aac aag gcc atc cgc ggc gac gag gcc ggc ctg 10367 Asn Ala Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu 475 480 485 gtg tac aac gcg ctg ctg gag cgc gtg gcc cgc tac aac agc acc aac 10415 Val Tyr Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn 490 495 500 gtg cag acc aac ctg gac cgc atg gtg acc gac gtg cgc gag gcc gtg 10463 Val Gln Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val 505 510 515 520 gcc cag cgc gag cgg ttc cac cgc gag tcc aac ctg gga tcc atg gtg 10511 Ala Gln Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val 525 530 535 gcg ctg aac gcc ttc ctc agc acc cag ccc gcc aac gtg ccc cgg ggc 10559 Ala Leu Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly 540 545 550 cag gag gac tac acc aac ttc atc agc gcc ctg cgc ctg atg gtg acc 10607 Gln Glu Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Thr 555 560 565 gag gtg ccc cag agc gag gtg tac cag tcc ggg ccg gac tac ttc ttc 10655 Glu Val Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe 570 575 580 cag acc agt cgc cag ggc ttg cag acc gtg aac ctg agc cag gcg ttc 10703 Gln Thr Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe 585 590 595 600 aag aac ttg cag ggc ctg tgg ggc gtg cag gcc ccg gtc ggg gac cgc 10751 Lys Asn Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg 605 610 615 gcg acg gtg tcg agc ctg ctg acg ccg aac tcg cgc ctg ctg ctg ctg 10799 Ala Thr Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu 620 625 630 ctg gtg gcc ccc ttc acg gac agc ggc agc atc aac cgc aac tcg tac 10847 Leu Val Ala Pro Phe Thr Asp Ser Gly Ser Ile Asn Arg Asn Ser Tyr 635 640 645 ctg ggc tac ctg att aac ctg tac cgc gag gcc atc ggc cag gcg cac 10895 Leu Gly Tyr Leu Ile Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His 650 655 660 gtg gac gag cag acc tac cag gag atc acc cac gtg agc cgc gcc ctg 10943 Val Asp Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu 665 670 675 680 ggc cag gac gac ccg ggc aat ctg gaa gcc acc ctg aac ttt ttg ctg 10991 Gly Gln Asp Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu 685 690 695 acc aac cgg tcg cag aag atc ccg ccc cag tac acg ctc agc gcc gag 11039 Thr Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Thr Leu Ser Ala Glu 700 705 710 gag gag cgc atc ctg cga tac gtg cag cag agc gtg ggc ctg ttc ctg 11087 Glu Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu 715 720 725 atg cag gag ggg gcc acc ccc agc gcc gcg ctc gac atg acc gcg cgc 11135 Met Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg 730 735 740 aac atg gag ccc agc atg tac gcc agc aac cgc ccg ttc atc aat aaa 11183 Asn Met Glu Pro Ser Met Tyr Ala Ser Asn Arg Pro Phe Ile Asn Lys 745 750 755 760 ctg atg gac tac ttg cat cgg gcg gcc gcc atg aac tct gac tat ttc 11231 Leu Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe 765 770 775 acc aac gcc atc ctg aat ccc cac tgg ctc ccg ccg ccg ggg ttc tac 11279 Thr Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr 780 785 790 acg ggc gag tac gac atg ccc gac ccc aat gac ggg ttc ctg tgg gac 11327 Thr Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp 795 800 805 gat gtg gac agc agc gtg ttc tcc ccc cga ccg ggt gct aac gag cgc 11375 Asp Val Asp Ser Ser Val Phe Ser Pro Arg Pro Gly Ala Asn Glu Arg 810 815 820 ccc ttg tgg aag aag gaa ggc agc gac cga cgc ccg tcc tcg gcg ctg 11423 Pro Leu Trp Lys Lys Glu Gly Ser Asp Arg Arg Pro Ser Ser Ala Leu 825 830 835 840 tcc ggc cgc gag ggt gct gcc gcg gcg gtg ccc gag gcc gcc agt cct 11471 Ser Gly Arg Glu Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro 845 850 855 ttc ccg agc ttg ccc ttc tcg ctg aac agt att cgc agc agc gag ctg 11519 Phe Pro Ser Leu Pro Phe Ser Leu Asn Ser Ile Arg Ser Ser Glu Leu 860 865 870 ggc agg atc acg cgc ccg cgc ttg ctg ggc gag gag gag tac ttg aat 11567 Gly Arg Ile Thr Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn 875 880 885 gac tcg ctg ttg aga ccc gag cgg gag aag aac ttc ccc aat aac ggg 11615 Asp Ser Leu Leu Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly 890 895 900 ata gag agc ctg gtg gac aag atg agc cgc tgg aag acg tat gcg cag 11663 Ile Glu Ser Leu Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala Gln 905 910 915 920 gag cac agg gac gat ccg tcg cag ggg gcc acg agc cgg ggc agc gcc 11711 Glu His Arg Asp Asp Pro Ser Gln Gly Ala Thr Ser Arg Gly Ser Ala 925 930 935 gcc cgt aaa cgc cgg tgg cac gac agg cag cgg gga ctg atg tgg gac 11759 Ala Arg Lys Arg Arg Trp His Asp Arg Gln Arg Gly Leu Met Trp Asp 940 945 950 gat gag gat tcc gcc gac gac agc agc gtg ttg gac ttg ggt ggg agt 11807 Asp Glu Asp Ser Ala Asp Asp Ser Ser Val Leu Asp Leu Gly Gly Ser 955 960 965 ggt aac ccg ttc gct cac ctg cgc ccc cgc atc ggg cgc atg atg 11852 Gly Asn Pro Phe Ala His Leu Arg Pro Arg Ile Gly Arg Met Met 970 975 980 taagagaaac cgaaaataaa tgatactcac caaggccatg gcgaccagcg tgcgttcgtt 11912 tcttctctgt tgttgtatct agt atg atg agg cgt gcg tac ccg gag ggt cct 11965 Met Met Arg Arg Ala Tyr Pro Glu Gly Pro 985 990 cct ccc tcg tac gag agc gtg atg cag cag gcg atg gcg gcg gcg gcg 12013 Pro Pro Ser Tyr Glu Ser Val Met Gln Gln Ala Met Ala Ala Ala Ala 995 1000 1005 gcg atg cag ccc ccg ctg gag gct cct tac gtg ccc ccg cgg tac 12058 Ala Met Gln Pro Pro Leu Glu Ala Pro Tyr Val Pro Pro Arg Tyr 1010 1015 1020 ctg gcg cct acg gag ggg cgg aac agc att cgt tac tcg gag ctg 12103 Leu Ala Pro Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu 1025 1030 1035 gca ccc ttg tac gat acc acc cgg ttg tac ctg gtg gac aac aag 12148 Ala Pro Leu Tyr Asp Thr Thr Arg Leu Tyr Leu Val Asp Asn Lys 1040 1045 1050 tcg gcg gac atc gcc tcg ctg aac tac cag aac gac cac agc aac 12193 Ser Ala Asp Ile Ala Ser Leu Asn Tyr Gln Asn Asp His Ser Asn 1055 1060 1065 ttc ctg acc acc gtg gtg cag aac aat gac ttc acc ccc acg gag 12238 Phe Leu Thr Thr Val Val Gln Asn Asn Asp Phe Thr Pro Thr Glu 1070 1075 1080 gcc agc acc cag acc atc aac ttt gac gag cgc tcg cgg tgg ggc 12283 Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg Trp Gly 1085 1090 1095 ggt cag ctg aaa acc atc atg cac acc aac atg ccc aac gtg aac 12328 Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro Asn Val Asn 1100 1105 1110 gag ttc atg tac agc aac aag ttc aag gcg cgg gtg atg gtc tcc 12373 Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser 1115 1120 1125 cgc aag acc ccc aac ggg gtg aca gtg aca gat ggt agt cag gat 12418 Arg Lys Thr Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln Asp 1130 1135 1140 atc ttg gag tat gaa tgg gtg gag ttt gag ctg ccc gaa ggc aac 12463 Ile Leu Glu Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn 1145 1150 1155 ttc tcg gtg acc atg acc atc gac ctg atg aac aac gcc atc atc 12508 Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile 1160 1165 1170 gac aat tac ttg gcg gtg ggg cgg cag aac ggg gtc ctg gag agc 12553 Asp Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser 1175 1180 1185 gat atc ggc gtg aag ttc gac act agg aac ttc agg ctg ggc tgg 12598 Asp Ile Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp 1190 1195 1200 gac ccc gtg acc gag ctg gtc atg ccc ggg gtg tac acc aac gag 12643 Asp Pro Val Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu 1205 1210 1215 gcc ttc cac ccc gat att gtc ttg ctg ccc ggc tgc ggg gtg gac 12688 Ala Phe His Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp 1220 1225 1230 ttc acc gag agc cgc ctc agc aac ctg ctg ggc att cgc aag agg 12733 Phe Thr Glu Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg 1235 1240 1245 cag ccc ttc cag gag ggc ttc cag atc atg tac gag gat ctg gag 12778 Gln Pro Phe Gln Glu Gly Phe Gln Ile Met Tyr Glu Asp Leu Glu 1250 1255 1260 ggg ggc aac atc ccc gcg ctc ctg gat gtc gac gcc tat gag aaa 12823 Gly Gly Asn Ile Pro Ala Leu Leu Asp Val Asp Ala Tyr Glu Lys 1265 1270 1275 agc aag gag gag agc gcc gcc gcg gcg act gca gct gta gcc acc 12868 Ser Lys Glu Glu Ser Ala Ala Ala Ala Thr Ala Ala Val Ala Thr 1280 1285 1290 gcc tct acc gag gtc agg ggc gat aat ttt gcc agc cct gca gca 12913 Ala Ser Thr Glu Val Arg Gly Asp Asn Phe Ala Ser Pro Ala Ala 1295 1300 1305 gtg gca gcg gcc gag gcg gct gaa acc gaa agt aag ata gtc att 12958 Val Ala Ala Ala Glu Ala Ala Glu Thr Glu Ser Lys Ile Val Ile 1310 1315 1320 cag ccg gtg gag aag gat agc aag gac agg agc tac aac gtg ctg 13003 Gln Pro Val Glu Lys Asp Ser Lys Asp Arg Ser Tyr Asn Val Leu 1325 1330 1335 ccg gac aag ata aac acc gcc tac cgc agc tgg tac ctg gcc tac 13048 Pro Asp Lys Ile Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr 1340 1345 1350 aac tat ggc gac ccc gag aag ggc gtg cgc tcc tgg acg ctg ctc 13093 Asn Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu 1355 1360 1365 acc acc tcg gac gtc acc tgc ggc gtg gag caa gtc tac tgg tcg 13138 Thr Thr Ser Asp Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser 1370 1375 1380 ctg ccc gac atg atg caa gac ccg gtc acc ttc cgc tcc acg cgt 13183 Leu Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg 1385 1390 1395 caa gtt agc aac tac ccg gtg gtg ggc gcc gag ctc ctg ccc gtc 13228 Gln Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val 1400 1405 1410 tac tcc aag agc ttc ttc aac gag cag gcc gtc tac tcg cag cag 13273 Tyr Ser Lys Ser Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln 1415 1420 1425 ctg cgc gcc ttc acc tcg ctc acg cac gtc ttc aac cgc ttc ccc 13318 Leu Arg Ala Phe Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro 1430 1435 1440 gag aac cag atc ctc gtc cgc ccg ccc gcg ccc acc att acc acc 13363 Glu Asn Gln Ile Leu Val Arg Pro Pro Ala Pro Thr Ile Thr Thr 1445 1450 1455 gtc agt gaa aac gtt cct gct ctc aca gat cac ggg acc ctg ccg 13408 Val Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro 1460 1465 1470 ctg cgc agc agt atc cgg gga gtc cag cgc gtg acc gtt act gac 13453 Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val Thr Val Thr Asp 1475 1480 1485 gcc aga cgc cgc acc tgc ccc tac gtc tac aag gcc ctg ggc ata 13498 Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile 1490 1495 1500 gtc gcg ccg cgc gtc ctc tcg agc cgc acc ttc taaaaa atg tcc att 13546 Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe Met Ser Ile 1505 1510 1515 ctc atc tcg ccc agt aat aac acc ggt tgg ggc ctg cgc gcg ccc 13591 Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg Ala Pro 1520 1525 1530 agc aag atg tac gga ggc gct cgc caa cgc tcc acg caa cac ccc 13636 Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His Pro 1535 1540 1545 gtg cgc gtg cgc ggg cac ttc cgc gct ccc tgg ggc gcc ctc aag 13681 Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 1550 1555 1560 ggc cgc gtg cgg tcg cgc acc acc gtc gac gac gtg atc gac cag 13726 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln 1565 1570 1575 gtg gtg gcc gac gcg cgc aac tac acc ccc gcc gcc gcg ccc gtc 13771 Val Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Val 1580 1585 1590 tcc acc gtg gac gcc gtc atc gac agc gtg gtg gcc gac gcg cgc 13816 Ser Thr Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg 1595 1600 1605 cgg tac gcc cgc gcc aag agc cgg cgg cgg cgc atc gcc cgg cgg 13861 Arg Tyr Ala Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg 1610 1615 1620 cac cgg agc acc ccc gcc atg cgc gcg gcg cga gcc ttg ctg cgc 13906 His Arg Ser Thr Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg 1625 1630 1635 agg gcc agg cgc acg gga cgc agg gcc atg ctc agg gcg gcc aga 13951 Arg Ala Arg Arg Thr Gly Arg Arg Ala Met Leu Arg Ala Ala Arg 1640 1645 1650 cgc gcg gcc tca ggc gcc agc gcc ggc agg acc cgg aga cgc gcg 13996 Arg Ala Ala Ser Gly Ala Ser Ala Gly Arg Thr Arg Arg Arg Ala 1655 1660 1665 gcc acg gcg gcg gca gcg gcc atc gcc agc atg tcc cgc ccg cgg 14041 Ala Thr Ala Ala Ala Ala Ala Ile Ala Ser Met Ser Arg Pro Arg 1670 1675 1680 cga ggg aac gtg tac tgg gtg cgc gac gcc gcc acc ggt gtg cgc 14086 Arg Gly Asn Val Tyr Trp Val Arg Asp Ala Ala Thr Gly Val Arg 1685 1690 1695 gtg ccc gtg cgc acc cgc ccc cct cgc act tgaagatgtt cacttcgcga 14136 Val Pro Val Arg Thr Arg Pro Pro Arg Thr 1700 1705 tgttgatgtg tcccagcggc gagg atg tcc aag cgc aaa ttc aag gaa gag 14187 Met Ser Lys Arg Lys Phe Lys Glu Glu 1710 1715 atg ctc cag gtc atc gcg cct gag atc tac ggc ccc gcg gtg gtg 14232 Met Leu Gln Val Ile Ala Pro Glu Ile Tyr Gly Pro Ala Val Val 1720 1725 1730 aag gag gaa aga aag ccc cgc aaa atc aag cgg gtc aaa aag gac 14277 Lys Glu Glu Arg Lys Pro Arg Lys Ile Lys Arg Val Lys Lys Asp 1735 1740 1745 aaa aag gaa gaa gaa agt gat gtg gac gga ctg gtg gag ttt gtg 14322 Lys Lys Glu Glu Glu Ser Asp Val Asp Gly Leu Val Glu Phe Val 1750 1755 1760 cgc gag ttc gcc ccc cgg cgg cgc gtg cag tgg cgc ggg cgg aag 14367 Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp Arg Gly Arg Lys 1765 1770 1775 gtg cgc ccg gtg ctg aga cca ggc act acg gtg gtc ttc acg ccc 14412 Val Arg Pro Val Leu Arg Pro Gly Thr Thr Val Val Phe Thr Pro 1780 1785 1790 ggc gag cgc tcc ggc acc gct tcc aag cgc tcc tac gac gag gtg 14457 Gly Glu Arg Ser Gly Thr Ala Ser Lys Arg Ser Tyr Asp Glu Val 1795 1800 1805 tac ggg gac gag gac atc ctc gag cag gcg gcc gag cgc ctg ggc 14502 Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu Gly 1810 1815 1820 gag ttt gct tac ggc aag cgc agc cgc tcc gcg ccg aag gaa gag 14547 Glu Phe Ala Tyr Gly Lys Arg Ser Arg Ser Ala Pro Lys Glu Glu 1825 1830 1835 gcg gtg tcc atc ccg ctg gac cac ggc aac ccc acg ccg agc ctc 14592 Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu 1840 1845 1850 aag ccc gtg acc ctg cag cag gtg ctg ccg acc gcg gcg ccg cgc 14637 Lys Pro Val Thr Leu Gln Gln Val Leu Pro Thr Ala Ala Pro Arg 1855 1860 1865 cgg ggg ttc aag cgc gag ggc gag gat ctg tac ccc acc atg cag 14682 Arg Gly Phe Lys Arg Glu Gly Glu Asp Leu Tyr Pro Thr Met Gln 1870 1875 1880 ctg atg gtg ccc aag cgc cag aag ctg gaa gac gtg ctg gag acc 14727 Leu Met Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu Thr 1885 1890 1895 atg aag gtg gac ccg gac gtg cag ccc gag gtc aag gtg cgg ccc 14772 Met Lys Val Asp Pro Asp Val Gln Pro Glu Val Lys Val Arg Pro 1900 1905 1910 atc aag cag gtg gcc ccg ggc ctg ggc gtg cag acc gtg gac atc 14817 Ile Lys Gln Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile 1915 1920 1925 aag atc ccc acg gag ccc atg gaa acg cag acc gag ccc gtg aaa 14862 Lys Ile Pro Thr Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys 1930 1935 1940 ccc agc acc agc acc atg gag gtg cag acg gat cct tgg atg cca 14907 Pro Ser Thr Ser Thr Met Glu Val Gln Thr Asp Pro Trp Met Pro 1945 1950 1955 tcg gct act agc cga aga ccc cgg cgc aag tac ggc gcg gcc agc 14952 Ser Ala Thr Ser Arg Arg Pro Arg Arg Lys Tyr Gly Ala Ala Ser 1960 1965 1970 ctg ctg atg ccc aac tac gcg ctg cat cct tcc atc atc ccc acg 14997 Leu Leu Met Pro Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr 1975 1980 1985 ccg ggc tac cgc ggc acg cgc ttc tac cgc ggt cat aca agc cgc 15042 Pro Gly Tyr Arg Gly Thr Arg Phe Tyr Arg Gly His Thr Ser Arg 1990 1995 2000 cgc cgc aag acc acc acc cgc cgc cgc cgt cgc cgc aca acc gct 15087 Arg Arg Lys Thr Thr Thr Arg Arg Arg Arg Arg Arg Thr Thr Ala 2005 2010 2015 gct gca tct acc cct gcc gcc ctg gtg cgg aga gtg tac cgc cgc 15132 Ala Ala Ser Thr Pro Ala Ala Leu Val Arg Arg Val Tyr Arg Arg 2020 2025 2030 ggc cgc gcg cct ctg acc ctg ccg cgc gcg cgc tac cac ccg agc 15177 Gly Arg Ala Pro Leu Thr Leu Pro Arg Ala Arg Tyr His Pro Ser 2035 2040 2045 att gcc att taaactttcg cctgctttgc agatca atg gcc ctc aca tgc 15227 Ile Ala Ile Met Ala Leu Thr Cys 2050 2055 cgc ctc cgc gtt ccc att acg ggc tac cga gga aga aaa ccg cgc 15272 Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly Arg Lys Pro Arg 2060 2065 2070 cgt aga agg ctg gcg ggg aac ggg atg cgt cgc cac cac cac cgg 15317 Arg Arg Arg Leu Ala Gly Asn Gly Met Arg Arg His His His Arg 2075 2080 2085 cgg cgg cgc gcc atc agc aag cgg ttg ggg gga ggc ttc ctg ccc 15362 Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe Leu Pro 2090 2095 2100 gcg ctg atc ccc atc atc gcc gcg gcg atc ggg gcg atc ccc ggc 15407 Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro Gly 2105 2110 2115 att gct tcc gtg gcg gtg cag gcc tct cag cgc cac tgagacacac 15453 Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 2120 2125 ttggaaacat cttgtaataa acca atg gac tct gac gct cct ggt cct gtg 15504 Met Asp Ser Asp Ala Pro Gly Pro Val 2130 2135 atg tgt ttt cgt aga cag atg gaa gac atc aat ttt tcg tcc ctg 15549 Met Cys Phe Arg Arg Gln Met Glu Asp Ile Asn Phe Ser Ser Leu 2140 2145 2150 gct ccg cga cac ggc acg cgg ccg ttc atg ggc acc tgg agc gac 15594 Ala Pro Arg His Gly Thr Arg Pro Phe Met Gly Thr Trp Ser Asp 2155 2160 2165 atc ggc acc agc caa ctg aac ggg ggc gcc ttc aat tgg agc agt 15639 Ile Gly Thr Ser Gln Leu Asn Gly Gly Ala Phe Asn Trp Ser Ser 2170 2175 2180 ctc tgg agc ggg ctt aag aat ttc ggg tcc acg ctt aaa acc tat 15684 Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser Thr Leu Lys Thr Tyr 2185 2190 2195 ggc agc aag gcg tgg aac agc acc aca ggg cag gcg ctg agg gat 15729 Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly Gln Ala Leu Arg Asp 2200 2205 2210 aag ctg aaa gag cag aac ttc cag cag aag gtg gtc gat ggc ctg 15774 Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val Val Asp Gly Leu 2215 2220 2225 gcc tcg ggc atc aac ggg gtg gtg gac ctg gcc aac cag gcc gtg 15819 Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn Gln Ala Val 2230 2235 2240 cag cgg cag atc aac agc cgc ctg gac ccg gtg ccg ccc gcc ggc 15864 Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro Ala Gly 2245 2250 2255 tcc gtg gag atg ccg cag gtg gag gag gag ctg cct ccc ctg gac 15909 Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu Asp 2260 2265 2270 aag cgg ggc gag aag cga ccc cgc ccc gac gcg gag gag acg ctg 15954 Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu 2275 2280 2285 ctg acg cac acg gac gag ccg ccc ccg tac gag gag gcg gtg aaa 15999 Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys 2290 2295 2300 ctg ggc ctg ccc acc acg cgg ccc atc gcg cct ctg gcc acc ggg 16044 Leu Gly Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly 2305 2310 2315 gtg ctg aaa ccc gaa agt agt aag ccc gcg acc ctg gac ttg cct 16089 Val Leu Lys Pro Glu Ser Ser Lys Pro Ala Thr Leu Asp Leu Pro 2320 2325 2330 cct ccc cag cct tcc cgc ccc tcc aca gtg gct aag cct ctg ccg 16134 Pro Pro Gln Pro Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro 2335 2340 2345 ccg gtg gcc gtg gcc cgc gcg cga ccc ggg ggc acc gcc cgc cct 16179 Pro Val Ala Val Ala Arg Ala Arg Pro Gly Gly Thr Ala Arg Pro 2350 2355 2360 cat gcg aac tgg cag agc act ctg aac agc atc gtg ggt ctg gga 16224 His Ala Asn Trp Gln Ser Thr Leu Asn Ser Ile Val Gly Leu Gly 2365 2370 2375 gtg cag agt gtg aag cgc cgc cgc tgc tat taaacctacc gtagcgctta 16274 Val Gln Ser Val Lys Arg Arg Arg Cys Tyr 2380 2385 acttgcttgt ctgtgtgtgt atgtattatg tcgccgccgc tgtcgccaga aggaggagtg 16334 aagaggcgcg tcgccgagtt gcaag atg gcc acc cca tcg atg ctg ccc cag 16386 Met Ala Thr Pro Ser Met Leu Pro Gln 2390 2395 tgg gcg tac atg cac atc gcc gga cag gac gct tcg gag tac ctg 16431 Trp Ala Tyr Met His Ile Ala Gly Gln Asp Ala Ser Glu Tyr Leu 2400 2405 2410 agt ccg ggt ctg gtg cag ttc gcc cgc gcc aca gac acc tac ttc 16476 Ser Pro Gly Leu Val Gln Phe Ala Arg Ala Thr Asp Thr Tyr Phe 2415 2420 2425 agt ctg ggg aac aag ttt agg aac ccc acg gtg gcg ccc acg cac 16521 Ser Leu Gly Asn Lys Phe Arg Asn Pro Thr Val Ala Pro Thr His 2430 2435 2440 gat gtg acc acc gac cgc agc cag cgg ctg acg ctg cgc ttc gtg 16566 Asp Val Thr Thr Asp Arg Ser Gln Arg Leu Thr Leu Arg Phe Val 2445 2450 2455 ccc gtg gac cgc gag gac aac acc tac tcg tac aaa gtg cgc tac 16611 Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr Lys Val Arg Tyr 2460 2465 2470 acg ctg gcc gtg ggc gac aac cgc gtg ctg gac atg gcc agc acc 16656 Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met Ala Ser Thr 2475 2480 2485 tac ttt gac atc cgc ggc gtg ctg gac cgg ggc cct agc ttc aaa 16701 Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser Phe Lys 2490 2495 2500 ccc tac tcc ggc acc gcc tac aat gct ctg gcc ccc aag gga gca 16746 Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly Ala 2505 2510 2515 ccc aac act tgc cag tgg aca tac aca gat aag caa acc gaa aaa 16791 Pro Asn Thr Cys Gln Trp Thr Tyr Thr Asp Lys Gln Thr Glu Lys 2520 2525 2530 aca gcc acg tat ggg aat gcg cct gta caa ggc att gcc atc aca 16836 Thr Ala Thr Tyr Gly Asn Ala Pro Val Gln Gly Ile Ala Ile Thr 2535 2540 2545 aaa gat ggt att caa ctt gga act gac agt gat gga aat cct gta 16881 Lys Asp Gly Ile Gln Leu Gly Thr Asp Ser Asp Gly Asn Pro Val 2550 2555 2560 tat gct caa aag aca ttt gaa ccc gaa cct caa gtg ggt gat gca 16926 Tyr Ala Gln Lys Thr Phe Glu Pro Glu Pro Gln Val Gly Asp Ala 2565 2570 2575 gaa tgg cat gac act aca ggt aca gat gaa aag tat gga ggc agg 16971 Glu Trp His Asp Thr Thr Gly Thr Asp Glu Lys Tyr Gly Gly Arg 2580 2585 2590 gca ctt aag cct gac acc aaa atg aag cct tgc tat ggt tct ttt 17016 Ala Leu Lys Pro Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe 2595 2600 2605 gcc aaa ccc act aac aaa gaa ggt gga cag gca aag aac aga aca 17061 Ala Lys Pro Thr Asn Lys Glu Gly Gly Gln Ala Lys Asn Arg Thr 2610 2615 2620 aaa act gat gga act ggc gaa gag cct gat att gat atg gca ttt 17106 Lys Thr Asp Gly Thr Gly Glu Glu Pro Asp Ile Asp Met Ala Phe 2625 2630 2635 ttt gac ggc aga aat gca act aca gct ggt ttg gct cca gaa att 17151 Phe Asp Gly Arg Asn Ala Thr Thr Ala Gly Leu Ala Pro Glu Ile 2640 2645 2650 gtt ttg tat act gag aat gtg gat ctg gag act cca gat acc cat 17196 Val Leu Tyr Thr Glu Asn Val Asp Leu Glu Thr Pro Asp Thr His 2655 2660 2665 att gta tac aaa gca ggc aca gat gac agc agc tct tcg att aat 17241 Ile Val Tyr Lys Ala Gly Thr Asp Asp Ser Ser Ser Ser Ile Asn 2670 2675 2680 ttg ggg cag caa tcc atg ccc aac aga ccc aac tac att ggg ttc 17286 Leu Gly Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe 2685 2690 2695 aga gac aac ttt atc ggg ctc atg tac tac aac agc act ggc aat 17331 Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn 2700 2705 2710 atg ggg gtg ctg gcc ggt cag gct tct cag ctg aat gct gtg gtt 17376 Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val 2715 2720 2725 gac ttg caa gac aga aac acc gaa ctg tcc tac cag ctc ttg ctt 17421 Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu 2730 2735 2740 gac tct ctg ggc gac aga acc ctg tat ttc agt atg tgg aat cag 17466 Asp Ser Leu Gly Asp Arg Thr Leu Tyr Phe Ser Met Trp Asn Gln 2745 2750 2755 gcg gtg gac agc tat gat cct gat gtg cgc att att gaa aac cat 17511 Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His 2760 2765 2770 ggt gtg gaa gat gaa ctt ccc aac tat tgc ttc cct ctg gat gct 17556 Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asp Ala 2775 2780 2785 gtt ggt agg aca gat act tat cag gga att aag ccc aat gga ggc 17601 Val Gly Arg Thr Asp Thr Tyr Gln Gly Ile Lys Pro Asn Gly Gly 2790 2795 2800 gat cca gcc aca tgg gcc aaa gat gac agc gcc aat gat gct aat 17646 Asp Pro Ala Thr Trp Ala Lys Asp Asp Ser Ala Asn Asp Ala Asn 2805 2810 2815 gaa atg ggc aag ggc aat cca ttc gcc atg gaa atc aac atc caa 17691 Glu Met Gly Lys Gly Asn Pro Phe Ala Met Glu Ile Asn Ile Gln 2820 2825 2830 gcc aac ctg tgg agg aac ttc ctc tac gcc aac gtg gcc ctg tac 17736 Ala Asn Leu Trp Arg Asn Phe Leu Tyr Ala Asn Val Ala Leu Tyr 2835 2840 2845 cta ccc gat tct tac aag tac acg ccg gcc aac gtc acc ctg ccc 17781 Leu Pro Asp Ser Tyr Lys Tyr Thr Pro Ala Asn Val Thr Leu Pro 2850 2855 2860 acc aac acc aac acc tac gat tat atg aac ggc cgg gtg gtg gcg 17826 Thr Asn Thr Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val Val Ala 2865 2870 2875 cct tcg ctg gtg gac tcc tac atc aac atc ggg gcg cgc tgg tcg 17871 Pro Ser Leu Val Asp Ser Tyr Ile Asn Ile Gly Ala Arg Trp Ser 2880 2885 2890 ctg gac ccc atg gac aac gtc aat ccc ttc aac cac cac cgc aac 17916 Leu Asp Pro Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn 2895 2900 2905 gcg ggc ttg cgc tac cgc tcc atg ctc ctg ggc aac ggg cgc tac 17961 Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr 2910 2915 2920 gtg ccc ttc cac atc cag gtg ccc cag aaa ttt ttc gcc atc aag 18006 Val Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys 2925 2930 2935 agc ctc ctg ctc ctg ccc ggg tcc tac acc tac gag tgg aac ttc 18051 Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe 2940 2945 2950 cgc aag gac gtc aac atg atc ctg cag agc tcc ctc ggc aac gac 18096 Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp 2955 2960 2965 ctg cgc acg gac ggg gcc tcc atc tcc ttc acc agc atc aac ctc 18141 Leu Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu 2970 2975 2980 tac gcc acc ttc ttc ccc atg gcg cac aac acg gcc tcc acg ctc 18186 Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu 2985 2990 2995 gag gcc atg ctg cgc aac gac acc aac gac cag tcc ttc aac gac 18231 Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp 3000 3005 3010 tac ctc tcg gcg gcc aac atg ctc tac ccc atc ccg gcc aac gcc 18276 Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala 3015 3020 3025 acc aac gtg ccc atc tcc atc ccc tcg cgc aac tgg gcc gcc ttc 18321 Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe 3030 3035 3040 cgc ggc tgg tcc ttc acg cgc ctc aag acc aag gag acg ccc tcg 18366 Arg Gly Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser 3045 3050 3055 ctg ggc tcc ggg ttc gac ccc tac ttc gtc tac tcg ggc tcc atc 18411 Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile 3060 3065 3070 ccc tac ctc gac ggc acc ttc tac ctc aac cac acc ttc aag aag 18456 Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys 3075 3080 3085 gtc tcc atc acc ttc gac tcc tcc gtc agc tgg ccc ggc aac gac 18501 Val Ser Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp 3090 3095 3100 cgg ctc ctg acg ccc aac gag ttc gaa atc aag cgc acc gtc gac 18546 Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp 3105 3110 3115 ggc gag ggc tac aac gtg gcc cag tgc aac atg acc aag gac tgg 18591 Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp 3120 3125 3130 ttc ctg gtc cag atg ctg gcc cac tac aac atc ggc tac cag ggc 18636 Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly 3135 3140 3145 ttc tac gtg ccc gag ggc tac aag gac cgc atg tac tcc ttc ttc 18681 Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe 3150 3155 3160 cgc aac ttc cag ccc atg agc cgc cag gtg gtg gac gag gtc aac 18726 Arg Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Val Asn 3165 3170 3175 tac aag gac tac cag gcc gtc acc ctg gcc tac cag cac aac aac 18771 Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn Asn 3180 3185 3190 tcg ggc ttc gtc ggc tac ctc gcg ccc acc atg cgc cag ggc cag 18816 Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln 3195 3200 3205 ccc tac ccc gcc aac tac ccg tac ccg ctc atc ggc aag agc gcc 18861 Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala 3210 3215 3220 gtc acc agc gtc acc cag aaa aag ttc ctc tgc gac agg gtc atg 18906 Val Thr Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met 3225 3230 3235 tgg cgc atc ccc ttc tcc agc aac ttc atg tcc atg ggc gcg ctc 18951 Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu 3240 3245 3250 acc gac ctc ggc cag aac atg ctc tat gcc aac tcc gcc cac gcg 18996 Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala 3255 3260 3265 cta gac atg aat ttc gaa gtc gac ccc atg gat gag tcc acc ctt 19041 Leu Asp Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu 3270 3275 3280 ctc tat gtt gtc ttc gaa gtc ttc gac gtc gtc cga gtg cac cag 19086 Leu Tyr Val Val Phe Glu Val Phe Asp Val Val Arg Val His Gln 3285 3290 3295 ccc cac cgc ggc gtc atc gag gcc gtc tac ctg cgc acc ccc ttc 19131 Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe 3300 3305 3310 tcg gcc ggt aac gcc acc acc taaattgcta cttgc atg atg gct gag 19179 Ser Ala Gly Asn Ala Thr Thr Met Met Ala Glu 3315 3320 gcc gcg ggc tcc ggc gag cag gag ctc agg gcc atc atc cgc gac 19224 Ala Ala Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile Arg Asp 3325 3330 3335 ctg ggc tgc ggg ccc tac ttc ctg ggc acc ttc gat aag cgc ttc 19269 Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg Phe 3340 3345 3350 ccg gga ttc atg gcc ccg cac aag ctg gcc tgc gcc atc gtc aac 19314 Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn 3355 3360 3365 acg gcc ggt cgc gag acc ggg ggc gag cac tgg ctg gcc ttc gcc 19359 Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala 3370 3375 3380 tgg aac ccg cgc tcg aac acc tgc tac ctc ttc gac ccc ttc ggg 19404 Trp Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly 3385 3390 3395 ttc tcg gac gag cgc ctc aag cag atc tac cag ttc gag tac gag 19449 Phe Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu 3400 3405 3410 ggc ctg ctg cgc cgc agc gcc ctg gcc acc gag gac cgc tgc gtc 19494 Gly Leu Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val 3415 3420 3425 acc ctg gaa aag tcc acc cag acc gtg cag ggt ccg cgc tcg gcc 19539 Thr Leu Glu Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala 3430 3435 3440 gcc tgc ggg ctc ttc tgc tgc atg ttc ctg cac gcc ttc gtg cac 19584 Ala Cys Gly Leu Phe Cys Cys Met Phe Leu His Ala Phe Val His 3445 3450 3455 tgg ccc gac cgc ccc atg gac aag aac ccc acc atg aac ttg ctg 19629 Trp Pro Asp Arg Pro Met Asp Lys Asn Pro Thr Met Asn Leu Leu 3460 3465 3470 acg ggg gtg ccc aac ggc atg ctc cag tcg ccc cag gtg gaa ccc 19674 Thr Gly Val Pro Asn Gly Met Leu Gln Ser Pro Gln Val Glu Pro 3475 3480 3485 acc ctg cgc cgc aac cag gag gcg ctc tac cgc ttc ctc aac tcc 19719 Thr Leu Arg Arg Asn Gln Glu Ala Leu Tyr Arg Phe Leu Asn Ser 3490 3495 3500 cac tcc gcc tac ttt cgc tcc cac cgc gcg cgc atc gag aag gcc 19764 His Ser Ala Tyr Phe Arg Ser His Arg Ala Arg Ile Glu Lys Ala 3505 3510 3515 acc gcc ttc gat cgc atg aac aat caa gac atg taaaccgtgt 19807 Thr Ala Phe Asp Arg Met Asn Asn Gln Asp Met 3520 3525 gtgtatgttt aaaatatctt ttaataaaca gcactttcat gttacacatg catctgagat 19867 gattattta gaa atc gaa agg gtt ctg ccg ggt ctc ggc atg gcc cgc 19915 Glu Ile Glu Arg Val Leu Pro Gly Leu Gly Met Ala Arg 3530 3535 3540 ggg cag gga cac gtt gcg gaa ctg gta ctt ggc cag cca ctt gaa 19960 Gly Gln Gly His Val Ala Glu Leu Val Leu Gly Gln Pro Leu Glu 3545 3550 3555 ctc ggg gat cag cag ttt cgg cag cgg ggt gtc ggg gaa gga gtc 20005 Leu Gly Asp Gln Gln Phe Arg Gln Arg Gly Val Gly Glu Gly Val 3560 3565 3570 ggt cca cag ctt ccg cgt cag ttg cag ggc gcc cag cag gtc ggg 20050 Gly Pro Gln Leu Pro Arg Gln Leu Gln Gly Ala Gln Gln Val Gly 3575 3580 3585 cgc gga gat ctt gaa atc gca gtt ggg acc cgc gtt ctg cgc gcg 20095 Arg Gly Asp Leu Glu Ile Ala Val Gly Thr Arg Val Leu Arg Ala 3590 3595 3600 aga gtt gcg gta cac ggg gtt gca gca ctg gaa cac cat cag ggc 20140 Arg Val Ala Val His Gly Val Ala Ala Leu Glu His His Gln Gly 3605 3610 3615 cgg gtg ctt cac gct cgc cag cac cgt cgc gtc ggt gat gct ctc 20185 Arg Val Leu His Ala Arg Gln His Arg Arg Val Gly Asp Ala Leu 3620 3625 3630 cac gtc gag gtc ctc ggc gtt ggc cat ccc gaa ggg ggt cat ctt 20230 His Val Glu Val Leu Gly Val Gly His Pro Glu Gly Gly His Leu 3635 3640 3645 gca ggt ctg cct tcc cat agt ggg cac gca ccc ggg ctt gtg gtt 20275 Ala Gly Leu Pro Ser His Ser Gly His Ala Pro Gly Leu Val Val 3650 3655 3660 gca atc gca gtg cag ggg gat cag cat cat ctg ggc ctg gtc ggc 20320 Ala Ile Ala Val Gln Gly Asp Gln His His Leu Gly Leu Val Gly 3665 3670 3675 gtt cat ccc cgg gta cat ggc ctt cat gaa agc ctc caa ttg cct 20365 Val His Pro Arg Val His Gly Leu His Glu Ser Leu Gln Leu Pro 3680 3685 3690 gaa agc ctg ctg ggc ctt ggc tcc ctc ggt gaa gaa gac ccc gca 20410 Glu Ser Leu Leu Gly Leu Gly Ser Leu Gly Glu Glu Asp Pro Ala 3695 3700 3705 gga ctt gct aga gaa ctg gtt ggt agc gca ccc ggc gtc gtg cac 20455 Gly Leu Ala Arg Glu Leu Val Gly Ser Ala Pro Gly Val Val His 3710 3715 3720 gca gca gcg cgc gtc gtt gtt ggc cag ctg cac cac gct gcg ccc 20500 Ala Ala Ala Arg Val Val Val Gly Gln Leu His His Ala Ala Pro 3725 3730 3735 cca gcg gtt ctg ggt gat ctt ggc ccg gtc ggg gtt ctc ctt cag 20545 Pro Ala Val Leu Gly Asp Leu Gly Pro Val Gly Val Leu Leu Gln 3740 3745 3750 cgc gcg ctg ccc gtt ctc gct cgc cac atc cat ctc gat cat gtg 20590 Arg Ala Leu Pro Val Leu Ala Arg His Ile His Leu Asp His Val 3755 3760 3765 ctc ctt ctg gat cat ggt ggt ccc gtg cag gca ccg cag ctt gcc 20635 Leu Leu Leu Asp His Gly Gly Pro Val Gln Ala Pro Gln Leu Ala 3770 3775 3780 ctc ggt ctc ggt gca ccc gtg cag cca cag cgc gca ccc ggt gca 20680 Leu Gly Leu Gly Ala Pro Val Gln Pro Gln Arg Ala Pro Gly Ala 3785 3790 3795 ctc cca gtt ctt gtg ggc gat ctg gga atg cgc gtg cac gaa ccc 20725 Leu Pro Val Leu Val Gly Asp Leu Gly Met Arg Val His Glu Pro 3800 3805 3810 ctg cag gaa gcg gcc cat cat ggt ggt cag ggt ctt gtt gct agt 20770 Leu Gln Glu Ala Ala His His Gly Gly Gln Gly Leu Val Ala Ser 3815 3820 3825 gaa ggt cag cgg gat gcc gcg gtg ctc ctc gtt gat gta cag gtg 20815 Glu Gly Gln Arg Asp Ala Ala Val Leu Leu Val Asp Val Gln Val 3830 3835 3840 gca gat gcg gcg gta cac ctc gcc ctg ctc ggg cat cag ctg gaa 20860 Ala Asp Ala Ala Val His Leu Ala Leu Leu Gly His Gln Leu Glu 3845 3850 3855 gtt ggc ttt cag gtc ggt ctc cac gcg gta gcg gtc cat cag tat 20905 Val Gly Phe Gln Val Gly Leu His Ala Val Ala Val His Gln Tyr 3860 3865 3870 agt cat gat ttc cat acc ctt ctc cca ggc cga gac gat ggg cag 20950 Ser His Asp Phe His Thr Leu Leu Pro Gly Arg Asp Asp Gly Gln 3875 3880 3885 gct cat agg gtt ctt cac cat cat ctt agc act agc agc cgc ggc 20995 Ala His Arg Val Leu His His His Leu Ser Thr Ser Ser Arg Gly 3890 3895 3900 cag ggg gtc gct ctc atc cag ggt ctc aaa gct ccg ctt gcc gtc 21040 Gln Gly Val Ala Leu Ile Gln Gly Leu Lys Ala Pro Leu Ala Val 3905 3910 3915 ctt ctc ggt gat ccg cac cgg ggg gta gct gaa gcc cac ggc cgc 21085 Leu Leu Gly Asp Pro His Arg Gly Val Ala Glu Ala His Gly Arg 3920 3925 3930 cag ctc ctc ctc ggc ctg cct ttc gtc ctc gct gtc ctg gct gac 21130 Gln Leu Leu Leu Gly Leu Pro Phe Val Leu Ala Val Leu Ala Asp 3935 3940 3945 gtc ctg cag gac cac atg ctt ggt ctt gcg ggg ttt ctt ctt ggg 21175 Val Leu Gln Asp His Met Leu Gly Leu Ala Gly Phe Leu Leu Gly 3950 3955 3960 cgg cag cgg cgg cgg aga tgc ttg tgg cga ggg gga gcg cga gtt 21220 Arg Gln Arg Arg Arg Arg Cys Leu Trp Arg Gly Gly Ala Arg Val 3965 3970 3975 ctc gct cac cac tac tat ctc ttc ctc ttc gtg gtc cga ggc cac 21265 Leu Ala His His Tyr Tyr Leu Phe Leu Phe Val Val Arg Gly His 3980 3985 3990 gcg gcg gta ggt atg tct ctt cgg ggg cag agg cgg agg cga cgg 21310 Ala Ala Val Gly Met Ser Leu Arg Gly Gln Arg Arg Arg Arg Arg 3995 4000 4005 gct ctc gcc gcc gcg act tgg cgg atg gct ggc aga gcc cct tcc 21355 Ala Leu Ala Ala Ala Thr Trp Arg Met Ala Gly Arg Ala Pro Ser 4010 4015 4020 gcg atc ggg ggt gcg ctc ccg gcg gcg ctc tga ctg act tcc tcc 21400 Ala Ile Gly Gly Ala Leu Pro Ala Ala Leu Leu Thr Ser Ser 4025 4030 gcg gcc ggc cat tgtgttctcc tagggaggaa caacaagc atg gag act cag 21452 Ala Ala Gly His Met Glu Thr Gln 4035 4040 cca tcg cca acc tcg cca tct gcc ccc acc acc gcc gac gag aag 21497 Pro Ser Pro Thr Ser Pro Ser Ala Pro Thr Thr Ala Asp Glu Lys 4045 4050 4055 cag cag aat gaa agc tta acc gcc ccg ccg ccc agc ccc gcc acc 21542 Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro Pro Ser Pro Ala Thr 4060 4065 4070 tcc gac gca gcc gcg gtc cca gac atg caa gag atg gag gaa tcc 21587 Ser Asp Ala Ala Ala Val Pro Asp Met Gln Glu Met Glu Glu Ser 4075 4080 4085 atc gag att gac ctg ggc tat gtg acg ccc gcg gag cac gag gag 21632 Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu Glu 4090 4095 4100 gag ctg gca gtg cgc ttt caa tcg tca agc cag gaa gat aaa gaa 21677 Glu Leu Ala Val Arg Phe Gln Ser Ser Ser Gln Glu Asp Lys Glu 4105 4110 4115 cag cca gag cag gaa gca gaa aac gag cag agt cag gct ggg ctc 21722 Gln Pro Glu Gln Glu Ala Glu Asn Glu Gln Ser Gln Ala Gly Leu 4120 4125 4130 gag cat gac ggc gac tac ctc cac ctg agc ggg gag gag gac gcg 21767 Glu His Asp Gly Asp Tyr Leu His Leu Ser Gly Glu Glu Asp Ala 4135 4140 4145 ctc atc aag cat ctg gcc cgg cag gcc atc atc gtc aag gat gcg 21812 Leu Ile Lys His Leu Ala Arg Gln Ala Ile Ile Val Lys Asp Ala 4150 4155 4160 ctg ctc gac cgc acc gag gtg ccc ctc agc gtg gag gag ctc agc 21857 Leu Leu Asp Arg Thr Glu Val Pro Leu Ser Val Glu Glu Leu Ser 4165 4170 4175 cgc gcc tac gag ctc aac ctc ttc tcg ccg cgc gtg ccc ccc aag 21902 Arg Ala Tyr Glu Leu Asn Leu Phe Ser Pro Arg Val Pro Pro Lys 4180 4185 4190 cgc cag ccc aac ggc acc tgc gag ccc aac ccg cgc ctc aac ttc 21947 Arg Gln Pro Asn Gly Thr Cys Glu Pro Asn Pro Arg Leu Asn Phe 4195 4200 4205 tac ccg gtc ttc gcg gtg ccc gag gcc ctg gcc acc tac cac atc 21992 Tyr Pro Val Phe Ala Val Pro Glu Ala Leu Ala Thr Tyr His Ile 4210 4215 4220 ttt ttc aag aac caa aag atc ccc gtc tcc tgt cgc gcc aac cgc 22037 Phe Phe Lys Asn Gln Lys Ile Pro Val Ser Cys Arg Ala Asn Arg 4225 4230 4235 acc cgc gcc gac gcc ctc ttc aac ctg ggc ccc ggc gcc cgc cta 22082 Thr Arg Ala Asp Ala Leu Phe Asn Leu Gly Pro Gly Ala Arg Leu 4240 4245 4250 cct gat atc gcc tcc ttg gaa gag gtt ccc aag atc ttc gag ggt 22127 Pro Asp Ile Ala Ser Leu Glu Glu Val Pro Lys Ile Phe Glu Gly 4255 4260 4265 ctg ggc agc gac gag act cgg gcc gca aac gct ctg caa gga gaa 22172 Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu Gln Gly Glu 4270 4275 4280 gga gga gag cat gag cac cac agc gcc ctg gtc gag ttg gaa ggc 22217 Gly Gly Glu His Glu His His Ser Ala Leu Val Glu Leu Glu Gly 4285 4290 4295 gac aac gcg cgg ctg gcg gtg ctc aaa cgc acg gtc gag ctg acc 22262 Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu Thr 4300 4305 4310 cat ttc gcc tac ccg gct ctg aac ctg ccc ccc aaa gtc atg agc 22307 His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser 4315 4320 4325 gcg gtc atg gac cag gtg ctc atc aag cgc gcg tcg ccc atc tcc 22352 Ala Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Ile Ser 4330 4335 4340 gag gac gag ggc atg caa gac tcc gag gat ggc aag ccc gtg gtc 22397 Glu Asp Glu Gly Met Gln Asp Ser Glu Asp Gly Lys Pro Val Val 4345 4350 4355 agc gac gag cag ctg gcc cgg tgg ctg ggt cct aat gct agt ccc 22442 Ser Asp Glu Gln Leu Ala Arg Trp Leu Gly Pro Asn Ala Ser Pro 4360 4365 4370 cag agt ttg gaa gag cgg cgc aag ctc atg atg gcc gtg gtc ctg 22487 Gln Ser Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu 4375 4380 4385 gtg acc gtg gag ctg gag tgc ctg cgc cgc ttc ttc gcc gac gcg 22532 Val Thr Val Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala 4390 4395 4400 gag acc ctg cgc aag gtc gag gag aac ctg cac tac ctc ttc agg 22577 Glu Thr Leu Arg Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg 4405 4410 4415 cac ggg ttc gtg cgc cag gcc tgc aag atc tcc aac gtg gag ctg 22622 His Gly Phe Val Arg Gln Ala Cys Lys Ile Ser Asn Val Glu Leu 4420 4425 4430 acc aac ctg gtc tcc tac atg ggc atc ttg cac gag aac cgc ctg 22667 Thr Asn Leu Val Ser Tyr Met Gly Ile Leu His Glu Asn Arg Leu 4435 4440 4445 ggg cag aac gtg ctg cac acc acc ctg cgc ggg gag gcc cgc cgc 22712 Gly Gln Asn Val Leu His Thr Thr Leu Arg Gly Glu Ala Arg Arg 4450 4455 4460 gac tac atc cgc gac tgc gtc tac ctc tac ctc tgc cac acc tgg 22757 Asp Tyr Ile Arg Asp Cys Val Tyr Leu Tyr Leu Cys His Thr Trp 4465 4470 4475 cag acg ggc atg ggc gtg tgg cag cag tgt ctg gag gag cag aac 22802 Gln Thr Gly Met Gly Val Trp Gln Gln Cys Leu Glu Glu Gln Asn 4480 4485 4490 ctg aaa gag ctc tgc aag ctc ctg cag aag aac ctc aag ggt ctg 22847 Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys Asn Leu Lys Gly Leu 4495 4500 4505 tgg acc ggg ttc gac gag cgg acc acc gcc tcg gac ctg gcc gac 22892 Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser Asp Leu Ala Asp 4510 4515 4520 ctc atc ttc ccc gag cgc ctc agg ctg acg ctg cgc aac ggc ctg 22937 Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg Asn Gly Leu 4525 4530 4535 ccc gac ttt atg agc caa agc atg ttg caa aac ttt cgc tct ttc 22982 Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg Ser Phe 4540 4545 4550 atc ctc gaa cgc tcc gga atc ctg ccc gcc acc tgc tcc gcg ctg 23027 Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala Leu 4555 4560 4565 ccc tcg gac ttc gtg ccg ctg acc ttc cgc gag tgc ccc ccg ccg 23072 Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro 4570 4575 4580 ctg tgg agc cac tgc tac ctg ctg cgc ctg gcc aac tac ctg gcc 23117 Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala 4585 4590 4595 tac cac tcg gac gtg atc gag gac gtc agc ggc gag ggc ctg ctt 23162 Tyr His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu 4600 4605 4610 gag tgc cac tgc cgc tgc aac ctc tgc acg ccg cac cgc tcc ctg 23207 Glu Cys His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu 4615 4620 4625 gcc tgc aac ccc cag ctg ctg agc gag acc cag atc atc ggc acc 23252 Ala Cys Asn Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr 4630 4635 4640 ttc gag ttg caa ggg ccc agc gat gac ggc gag gga gcc aag ggg 23297 Phe Glu Leu Gln Gly Pro Ser Asp Asp Gly Glu Gly Ala Lys Gly 4645 4650 4655 ggt ctg aaa ctc acc ccg ggg ctg tgg acc tcg gcc tac ttg cgc 23342 Gly Leu Lys Leu Thr Pro Gly Leu Trp Thr Ser Ala Tyr Leu Arg 4660 4665 4670 aag ttc gtg ccc gag gac tac cat ccc ttc gag atc agg ttc tac 23387 Lys Phe Val Pro Glu Asp Tyr His Pro Phe Glu Ile Arg Phe Tyr 4675 4680 4685 gag gac caa tcc cag ccg cct aag gcc gag ctg tcg gcc tgc gtc 23432 Glu Asp Gln Ser Gln Pro Pro Lys Ala Glu Leu Ser Ala Cys Val 4690 4695 4700 atc acc cag ggg gcc atc ctg gcc caa ttg caa gcc atc cag aaa 23477 Ile Thr Gln Gly Ala Ile Leu Ala Gln Leu Gln Ala Ile Gln Lys 4705 4710 4715 tcc cgc caa gaa ttc ttg ctg aaa aag ggc cgc ggg gtc tac ctc 23522 Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly Arg Gly Val Tyr Leu 4720 4725 4730 gac ccc cag acc ggt gag gag ctc aac ccc ggc ttc ccc cag gat 23567 Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro Gly Phe Pro Gln Asp 4735 4740 4745 gcc ccg agg aaa caa gaa gct gaa agt gga gct gcc gcc cgt gga 23612 Ala Pro Arg Lys Gln Glu Ala Glu Ser Gly Ala Ala Ala Arg Gly 4750 4755 4760 gga ttt gga gga aga ctg gga gaa cag cag tca ggc aga gga gga 23657 Gly Phe Gly Gly Arg Leu Gly Glu Gln Gln Ser Gly Arg Gly Gly 4765 4770 4775 gat gga gga aga ctg gga cag cac tca ggc aga gga gga cag cct 23702 Asp Gly Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln Pro 4780 4785 4790 gca aga cag tct gga gga aga cga gga gga ggc aga ggt gga aga 23747 Ala Arg Gln Ser Gly Gly Arg Arg Gly Gly Gly Arg Gly Gly Arg 4795 4800 4805 agc agc cgc cgc cag acc gtc gtc ctc ggc ggg gga gaa agc aag 23792 Ser Ser Arg Arg Gln Thr Val Val Leu Gly Gly Gly Glu Ser Lys 4810 4815 4820 cag cac gga tac cat ctc cgc tcc ggg tcg ggg tcc cgc tcg gcc 23837 Gln His Gly Tyr His Leu Arg Ser Gly Ser Gly Ser Arg Ser Ala 4825 4830 4835 cca cag tagatgggac gagaccgggc gattcccgaa ccccaccatc cagaccggta 23893 Pro Gln agaaggagcg gcagggatac aagtcctggc gggggcacaa aaacgccatc gtctcctgct 23953 tgcaggcctg cgggggcaac atctccttca ccaggcgcta cctgctcttc caccgcgggg 24013 tgaacttccc ccgcaacatc ttgcattact accgtcacct ccacagcccc tactacttcc 24073 aagaagaggc agcagcagaa aaagaccagc agaaaaccag cagctagaaa atccacagcg 24133 gcagcaggtg gactgaggat cgcggcgaac gagccggcgc agacccggga gctgaggaac 24193 cggatctttc ccaccctcta tgccatcttc cagcagagtc gggggcagga gcaggaactg 24253 aaagtcaaga accgttctct gcgctcgctc acccgcagtt gtctgtatca caagagcgaa 24313 gaccaacttc agcgcactct cgaggacgcc gaggctctct tcaacaagta ctgcgcgctc 24373 actcttaaag agtagcccgc gcccgcccag tcgcagaaaa aggcgggaat tacgtcacct 24433 gtgcccttcg ccctagccgc ctccacccat c atg agc aaa gag att ccc acg 24485 Met Ser Lys Glu Ile Pro Thr 4840 4845 cct tac atg tgg agc tac cag ccc cag atg ggc ctg gcc gcc ggc 24530 Pro Tyr Met Trp Ser Tyr Gln Pro Gln Met Gly Leu Ala Ala Gly 4850 4855 4860 gcc gcc cag gac tac tcc acc cgc atg aat tgg ctc agc gcc ggg 24575 Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn Trp Leu Ser Ala Gly 4865 4870 4875 ccc gcg atg atc tca cgg gtg aat gac atc cgc gcc cac cga aac 24620 Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg Ala His Arg Asn 4880 4885 4890 cag ata ctc cta gaa cag tca gcg ctc acc gcc acg ccc cgc aat 24665 Gln Ile Leu Leu Glu Gln Ser Ala Leu Thr Ala Thr Pro Arg Asn 4895 4900 4905 cac ctc aat ccg cgt aat tgg ccc gcc gcc ctg gtg tac cag gaa 24710 His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr Gln Glu 4910 4915 4920 att ccc cag ccc acg acc gta cta ctt ccg cga gac gcc cag gcc 24755 Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln Ala 4925 4930 4935 gaa gtc cag ctg act aac tca ggt gtc cag ctg gcg ggc ggc gcc 24800 Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 4940 4945 4950 acc ctg tgt cgt cac cgc ccc gct cag ggt ata aag cgg ctg gtg 24845 Thr Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val 4955 4960 4965 atc cgg ggc aga ggc aca cag ctc aac gac gag gtg gtg agc tct 24890 Ile Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser 4970 4975 4980 tcg ctg ggt ctg cga cct gac gga gtc ttc caa atc gcc gga tcg 24935 Ser Leu Gly Leu Arg Pro Asp Gly Val Phe Gln Ile Ala Gly Ser 4985 4990 4995 ggg aga tct tcc ttc acg cct cgt cag gcg gtc ctg act ttg gag 24980 Gly Arg Ser Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu 5000 5005 5010 agt tcg tcc tcg cag ccc cgc tcg ggc ggc atc ggc act ctc cag 25025 Ser Ser Ser Ser Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln 5015 5020 5025 ttc gtg gag gag ttc act ccc tcg gtc tac ttc aac ccc ttc tcc 25070 Phe Val Glu Glu Phe Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser 5030 5035 5040 ggc tcc ccc ggc cac tac ccg gac gag ttc atc ccg aac ttt gac 25115 Gly Ser Pro Gly His Tyr Pro Asp Glu Phe Ile Pro Asn Phe Asp 5045 5050 5055 gcc atc agc gag tcg gtg gac ggc tac gat tga atg tcc cat ggt 25160 Ala Ile Ser Glu Ser Val Asp Gly Tyr Asp Met Ser His Gly 5060 5065 5070 ggc gcg gct gac cta gct cgg ctt cga cac ctg gac cac tgc cgc 25205 Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp His Cys Arg 5075 5080 5085 cgc ttt cgc tgc ttc gct cgg gac ctc gcc gag ttc acc tac ttc 25250 Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Thr Tyr Phe 5090 5095 5100 gag ctg ccc gag gag cat cct cag ggc ccg gcc cac gga gtg cgg 25295 Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val Arg 5105 5110 5115 atc gtc gtc gaa ggg ggc cta gac tcc cac ctg ctt cgg atc ttc 25340 Ile Val Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 5120 5125 5130 agc cag cgc ccg atc ctg gtc gag cgc caa cag ggc aac acc ctc 25385 Ser Gln Arg Pro Ile Leu Val Glu Arg Gln Gln Gly Asn Thr Leu 5135 5140 5145 ctg acc ctc tac tgc atc tgc gac cac ccc ggc ctg cat gaa agt 25430 Leu Thr Leu Tyr Cys Ile Cys Asp His Pro Gly Leu His Glu Ser 5150 5155 5160 ctt tgt tgt ctg ctg tgt act gag tat aat aaa agc tgagatcagc 25476 Leu Cys Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 5165 5170 gactactccg gactcaactg tggtgtttct gcatccatca accagtctct gaccttcacc 25536 gggaacgaga ccgagctcca gctccagtgt aagccccaca agaagtacct cacctggctg 25596 taccagggct ccccgatcgc cgttgttaac cactgcgacg acgacggagt cctgctgaac 25656 ggccccgcca accttacttt ttccacccgc agaagcaagc tactgctctt cagacccttc 25716 ctccccggga tctatcagtg catctcggga ccctgccatc acaccttcca cctgatcccg 25776 aataccacct cttccccagc accgctcccc actaacaacc aaactaacca ccaacgccac 25836 cgtcgagacc tttcctctga ttctaatacc actaccggag gtgagctccg aggtactaag 25896 aagtcctcac ctgggattta ttacggcccc tgggaggtgg tggggttaat agctttaggc 25956 ttagtagcgg gtgggctttt ggctctctgc tacctatacc tcccttgctg ttcctactta 26016 gtggtgcttt gttgctggtt taagaa atg ggg aag atc acc cta gtg tgc 26066 Met Gly Lys Ile Thr Leu Val Cys 5175 5180 ggt gtg ctg gtg acg gtg gtg ctt tcg att ctg gga ggg gga agc 26111 Gly Val Leu Val Thr Val Val Leu Ser Ile Leu Gly Gly Gly Ser 5185 5190 5195 gcg gct gta gtg acg gag aag aag gcc gat ccc tgc ttg act ttc 26156 Ala Ala Val Val Thr Glu Lys Lys Ala Asp Pro Cys Leu Thr Phe 5200 5205 5210 aat ccc gat aaa tgc cgg ctg agt ttt cag cca gat ggc aat cgg 26201 Asn Pro Asp Lys Cys Arg Leu Ser Phe Gln Pro Asp Gly Asn Arg 5215 5220 5225 tgc acg gtg ctg atc aag tgc gga tgg gaa tgc gag agc gtg gcg 26246 Cys Thr Val Leu Ile Lys Cys Gly Trp Glu Cys Glu Ser Val Ala 5230 5235 5240 atc cag tat aaa aac aag acg cgg aac aat act ctc gcg tcc aca 26291 Ile Gln Tyr Lys Asn Lys Thr Arg Asn Asn Thr Leu Ala Ser Thr 5245 5250 5255 tgg cag ccc ggg gac ccc gag tgg tac acc gtc tct gtc cct ggt 26336 Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val Pro Gly 5260 5265 5270 gct gac ggc tcc ctc cac acg gtg aac aac act ttc att ttt gag 26381 Ala Asp Gly Ser Leu His Thr Val Asn Asn Thr Phe Ile Phe Glu 5275 5280 5285 cac atg tgc gaa acc gcc atg ttc atg agc aag cag tac ggt atg 26426 His Met Cys Glu Thr Ala Met Phe Met Ser Lys Gln Tyr Gly Met 5290 5295 5300 tgg ccc cca cga aaa gag aat atc gtg gtc ttc tcc atc gct tac 26471 Trp Pro Pro Arg Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr 5305 5310 5315 agc gcg tgc acg gtg cta atc acc gcg atc gtg tgc ctg agc att 26516 Ser Ala Cys Thr Val Leu Ile Thr Ala Ile Val Cys Leu Ser Ile 5320 5325 5330 cac atg ctc atc gct att cgc ccc aga aat aat gcc gag aaa gag 26561 His Met Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu 5335 5340 5345 aaa cag cca taacacactt ttttcacaca ccttgttttt tacagaca atg cgt 26614 Lys Gln Pro Met Arg 5350 ctg tta att ttt gtt atc att aca ctc agc ttt aac tat gcc cat 26659 Leu Leu Ile Phe Val Ile Ile Thr Leu Ser Phe Asn Tyr Ala His 5355 5360 5365 ggc tat gca aat ata caa aaa acc ctc tat gta ggc tct gac tct 26704 Gly Tyr Ala Asn Ile Gln Lys Thr Leu Tyr Val Gly Ser Asp Ser 5370 5375 5380 aca tta gaa ggt act caa tct caa gcc agg gtt tca tgg tat ttt 26749 Thr Leu Glu Gly Thr Gln Ser Gln Ala Arg Val Ser Trp Tyr Phe 5385 5390 5395 tat aaa ggc tct gat gac cca att act ctt tgc aaa ggt gat cag 26794 Tyr Lys Gly Ser Asp Asp Pro Ile Thr Leu Cys Lys Gly Asp Gln 5400 5405 5410 ggg cgc ata aca aag cca cct atc aca ttt agc tgc acc aga aca 26839 Gly Arg Ile Thr Lys Pro Pro Ile Thr Phe Ser Cys Thr Arg Thr 5415 5420 5425 aac ctc acg ctt tta tcc att aca aaa gaa tat gct ggc act tat 26884 Asn Leu Thr Leu Leu Ser Ile Thr Lys Glu Tyr Ala Gly Thr Tyr 5430 5435 5440 tac agc aca aat ttt cat cgt ggg caa gat aaa tat tat act gtt 26929 Tyr Ser Thr Asn Phe His Arg Gly Gln Asp Lys Tyr Tyr Thr Val 5445 5450 5455 aag gta gaa aac cct acc acc cct aga aca act aca aag ccc acc 26974 Lys Val Glu Asn Pro Thr Thr Pro Arg Thr Thr Thr Lys Pro Thr 5460 5465 5470 aca act aag aag ccc act aca cct aag aag cct acc aca ccc aaa 27019 Thr Thr Lys Lys Pro Thr Thr Pro Lys Lys Pro Thr Thr Pro Lys 5475 5480 5485 acc act aag aca aca act gct aag acc act acc aca aag cca acc 27064 Thr Thr Lys Thr Thr Thr Ala Lys Thr Thr Thr Thr Lys Pro Thr 5490 5495 5500 aca acc agc acc aca ctt gct ata act aca cac aca cac act gag 27109 Thr Thr Ser Thr Thr Leu Ala Ile Thr Thr His Thr His Thr Glu 5505 5510 5515 ctg acc tca cag gca act act gaa aat gat ttg gtt gcc ctg ttg 27154 Leu Thr Ser Gln Ala Thr Thr Glu Asn Asp Leu Val Ala Leu Leu 5520 5525 5530 caa aag ggg gag aac agt agc agc agt cct ctg cct act acc ccc 27199 Gln Lys Gly Glu Asn Ser Ser Ser Ser Pro Leu Pro Thr Thr Pro 5535 5540 5545 agt gag gaa ata ccc aag tcc atg gtt ggc att atc gct gct gta 27244 Ser Glu Glu Ile Pro Lys Ser Met Val Gly Ile Ile Ala Ala Val 5550 5555 5560 gtg gtg tgt atg ctg att atc atc ttg tgc atg atg tac tat gcc 27289 Val Val Cys Met Leu Ile Ile Ile Leu Cys Met Met Tyr Tyr Ala 5565 5570 5575 tgc tac tac aga aaa cac agg ctg aac aac aaa ctg gac ccc tta 27334 Cys Tyr Tyr Arg Lys His Arg Leu Asn Asn Lys Leu Asp Pro Leu 5580 5585 5590 ctg agt gtt gat ttt taatttttta gaaccatgaa gatcctaagc ctttttgttt 27389 Leu Ser Val Asp Phe 5595 tttctataat tattacctct gctatttgtg aatcagtgga taaggacgtt actgtcacca 27449 ctggctctaa ttatacacta aaagggcctt cctcaggtat gctttcgtgg tattgttatt 27509 ttggaaatga tgataaacag acagagctat gtaactttca gaacggcaaa accaaaaatt 27569 ctaaaataga taactatcaa tgccagggta ctaatttagt actgatgaat atcacgaaag 27629 catatgctgg cagttattcc tgtcctggac aaaacaccga ggaaatgatt ttttacaaat 27689 taattgtagt tgaccctact actccagcac cacccaccac aaccaaggca cataccacag 27749 acacacagga aaccactcca gaggcagaag tagcagagtt agcaaagcag attcatgaag 27809 attcatttgt tgccaatacc cccacacacc ccggaccgca atgtccaggg ccattagtca 27869 gcggcattgt cggtgtgctt tgcgggttag cagttataat catctgcatg ttcatttttg 27929 cttgctgcta cagaaggctt caccgacaaa aatcagaccc actgctgaac ctctatgttt 27989 aatttttgat tttccagagc c atg aag gca ctt agc act tta gta ttt ttg 28040 Met Lys Ala Leu Ser Thr Leu Val Phe Leu 5600 5605 tcc ttg att ggc att gtt ttc agt gct ggg ttt ttg aaa aat ctt 28085 Ser Leu Ile Gly Ile Val Phe Ser Ala Gly Phe Leu Lys Asn Leu 5610 5615 5620 acc att att gaa ggt gat aat gca aca ctg gta gga atc agc ggt 28130 Thr Ile Ile Glu Gly Asp Asn Ala Thr Leu Val Gly Ile Ser Gly 5625 5630 5635 cag aat gtt agt tgg cta aaa tat cat cta gat ggg tgg aaa cct 28175 Gln Asn Val Ser Trp Leu Lys Tyr His Leu Asp Gly Trp Lys Pro 5640 5645 5650 att tgc acc tgg aat gtc agt gtg tac aca tgc cat ggt gtt aac 28220 Ile Cys Thr Trp Asn Val Ser Val Tyr Thr Cys His Gly Val Asn 5655 5660 5665 ctc acc att acc aat gcc acc caa gat cag aat ggc agg ttt aag 28265 Leu Thr Ile Thr Asn Ala Thr Gln Asp Gln Asn Gly Arg Phe Lys 5670 5675 5680 ggt cag agt ttc act agc aac aat ggg tat gaa acc cat aac atg 28310 Gly Gln Ser Phe Thr Ser Asn Asn Gly Tyr Glu Thr His Asn Met 5685 5690 5695 ttc atc tat gat gtc act gtc ata tca aat aag act aca cct acc 28355 Phe Ile Tyr Asp Val Thr Val Ile Ser Asn Lys Thr Thr Pro Thr 5700 5705 5710 aca cag aca ccc act aca cat agc tca act cat gcc atg cag acc 28400 Thr Gln Thr Pro Thr Thr His Ser Ser Thr His Ala Met Gln Thr 5715 5720 5725 act cag aca acc aca tac act aca tct act gag tcc acc acc acc 28445 Thr Gln Thr Thr Thr Tyr Thr Thr Ser Thr Glu Ser Thr Thr Thr 5730 5735 5740 act aca gca gag gta tcc agc aca gcg cct cag ccc cag gca ttg 28490 Thr Thr Ala Glu Val Ser Ser Thr Ala Pro Gln Pro Gln Ala Leu 5745 5750 5755 gct ttg atg gct cag cct agc agc atg act gct aaa acc aat gag 28535 Ala Leu Met Ala Gln Pro Ser Ser Met Thr Ala Lys Thr Asn Glu 5760 5765 5770 cag act act gaa ttt ttg tcc act att cag agc agc acc aca gct 28580 Gln Thr Thr Glu Phe Leu Ser Thr Ile Gln Ser Ser Thr Thr Ala 5775 5780 5785 acc tcg agt gcc ttc tct agc acc gcc aat ctc acc tcg ctt tcc 28625 Thr Ser Ser Ala Phe Ser Ser Thr Ala Asn Leu Thr Ser Leu Ser 5790 5795 5800 tct acg cca atc agt aac gct act acc tcc ccc gct cct ctt ccc 28670 Ser Thr Pro Ile Ser Asn Ala Thr Thr Ser Pro Ala Pro Leu Pro 5805 5810 5815 act cct ctg aag caa tcc gag tct agc acg cag ctg cag atc acc 28715 Thr Pro Leu Lys Gln Ser Glu Ser Ser Thr Gln Leu Gln Ile Thr 5820 5825 5830 ctg ctc att gtg atc ggg gtg gtc atc ctg gca gtg ctg ctc tac 28760 Leu Leu Ile Val Ile Gly Val Val Ile Leu Ala Val Leu Leu Tyr 5835 5840 5845 ttt atc ttc tgc cgc cgc atc ccc aac gcg aaa ccg gcc tac aag 28805 Phe Ile Phe Cys Arg Arg Ile Pro Asn Ala Lys Pro Ala Tyr Lys 5850 5855 5860 ccc att gtt atc ggg acg ccg gag ccg ctt cag gtg gag gga ggt 28850 Pro Ile Val Ile Gly Thr Pro Glu Pro Leu Gln Val Glu Gly Gly 5865 5870 5875 cta agg aat ctt ctc ttc tct ttt aca gta tgg tgatttgaac 28893 Leu Arg Asn Leu Leu Phe Ser Phe Thr Val Trp 5880 5885 tatgattcct agacatttca ttatcacttc tctaatctgt gtgctccaag tctgtgccac 28953 cctcgctctc gtggctaacg cgagtccaga ctgcattgga gcgttcgcct cctacgtgct 29013 ctttgccttc atcacctgca tctgctgctg tagcatagtc tgcctgctta tcaccttctt 29073 ccagttcgtt gactgggtct ttgtgcgcat cgcctacctg cgccaccacc cccagtaccg 29133 cgaccagaga gtggcgcaac tgttgagact catctg atg ata agc atg cgg gct 29187 Met Ile Ser Met Arg Ala 5890 ctg cta cta ctt ctc gcg ctt ctg cta gct ccc ctc gcc gcc ccc 29232 Leu Leu Leu Leu Leu Ala Leu Leu Leu Ala Pro Leu Ala Ala Pro 5895 5900 5905 cta tcc ctc aaa tcc ccc acc cag tcc cct gaa gag gtt cga aaa 29277 Leu Ser Leu Lys Ser Pro Thr Gln Ser Pro Glu Glu Val Arg Lys 5910 5915 5920 tgt aaa ttc caa gaa ccc tgg aaa ttc ctt tca tgc tac aaa ctc 29322 Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Ser Cys Tyr Lys Leu 5925 5930 5935 aaa tca gaa atg cac ccc agc tgg atc atg atc gtt gga atc gta 29367 Lys Ser Glu Met His Pro Ser Trp Ile Met Ile Val Gly Ile Val 5940 5945 5950 aac atc ctt gcc tgt acc ctc ttc tcc ttt gtg att tac ccc cgc 29412 Asn Ile Leu Ala Cys Thr Leu Phe Ser Phe Val Ile Tyr Pro Arg 5955 5960 5965 ttt gac ttt ggg tgg aac gca ccc gag gcg ctc tgg ctc ccg cct 29457 Phe Asp Phe Gly Trp Asn Ala Pro Glu Ala Leu Trp Leu Pro Pro 5970 5975 5980 gat ccc gac aca cca cca cag cag cag caa aat cag gca cag gca 29502 Asp Pro Asp Thr Pro Pro Gln Gln Gln Gln Asn Gln Ala Gln Ala 5985 5990 5995 cat gca cca cca cag cct agg cca caa tac atg ccc atc tta gac 29547 His Ala Pro Pro Gln Pro Arg Pro Gln Tyr Met Pro Ile Leu Asp 6000 6005 6010 tat gag gcc gag cca cag cga gcc atg ctt cct gct att agt tac 29592 Tyr Glu Ala Glu Pro Gln Arg Ala Met Leu Pro Ala Ile Ser Tyr 6015 6020 6025 ttc aat cta acc ggc gga gat gac tgaccccatg gccaacaaca 29636 Phe Asn Leu Thr Gly Gly Asp Asp 6030 6035 ccgtcaacga cctcctggac atggacggcc gcgcctcgga gcagcgactc gcccaactcc 29696 gcatccgcca gcagcaggag agagccgtca aggagctgca ggacgcggtg gccatccacc 29756 agtgcaagag aggcatcttc tgcctggtga agcaggccaa gatctccttc gaggtcacgt 29816 ccaccgacca tcgcctctcc tacgagctcc tgcagcagcg ccagaagttc acctgcctgg 29876 tcggagtcaa ccccatcgtc atcacccagc agtctggcga taccaagggt tgcatccact 29936 gctcctgcga ctcccccgag tgcgttcaca ccctgatcaa gaccctctgc ggcctccgcg 29996 acctcctccc catgaactaa tcaactaacc ccctacccct ttaccctcca gtaaaaataa 30056 agattaaaaa tgattgaatt gatcaataaa gaatcactta cttgaaatct gaaaccaggt 30116 ctctgtcc atg ttt tct gtc agc agc act tca ctc ccc tct tcc caa 30163 Met Phe Ser Val Ser Ser Thr Ser Leu Pro Ser Ser Gln 6040 6045 ctc tgg tac tgc agg ccc cgg cgg gct gca aac ttc ctc cac act 30208 Leu Trp Tyr Cys Arg Pro Arg Arg Ala Ala Asn Phe Leu His Thr 6050 6055 6060 ctg aag ggg atg tca aat tcc tcc tgt ccc tca atc ttc att ttt 30253 Leu Lys Gly Met Ser Asn Ser Ser Cys Pro Ser Ile Phe Ile Phe 6065 6070 6075 atc ttc tat cag atg tcc aaa aag cgc gcg cgg gtg gat gat ggc 30298 Ile Phe Tyr Gln Met Ser Lys Lys Arg Ala Arg Val Asp Asp Gly 6080 6085 6090 ttc gac ccc gtg tac ccc tac gat gca gac aac gca ccg act gtg 30343 Phe Asp Pro Val Tyr Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val 6095 6100 6105 ccc ttc atc aac cct ccc ttc gtc tct tca gat gga ttc caa gaa 30388 Pro Phe Ile Asn Pro Pro Phe Val Ser Ser Asp Gly Phe Gln Glu 6110 6115 6120 aag ccc ctg ggg gtg ttg tcc ctg cga ctg gcc gac ccc gtc acc 30433 Lys Pro Leu Gly Val Leu Ser Leu Arg Leu Ala Asp Pro Val Thr 6125 6130 6135 acc aag aat ggg gct gtc acc ctc aag ctg ggg gag ggg gtg gac 30478 Thr Lys Asn Gly Ala Val Thr Leu Lys Leu Gly Glu Gly Val Asp 6140 6145 6150 ctc gac gac tcg gga aaa ctc atc tcc aaa aat gcc acc aag gcc 30523 Leu Asp Asp Ser Gly Lys Leu Ile Ser Lys Asn Ala Thr Lys Ala 6155 6160 6165 act gcc cct ctc agt att tcc aac ggc acc att tcc ctt aac atg 30568 Thr Ala Pro Leu Ser Ile Ser Asn Gly Thr Ile Ser Leu Asn Met 6170 6175 6180 gcc gcc cct ttt tac aac aac aat gga acg tta agt ctc aat gtt 30613 Ala Ala Pro Phe Tyr Asn Asn Asn Gly Thr Leu Ser Leu Asn Val 6185 6190 6195 tct aca cca tta gca gta ttt ccc act ttt aac act tta ggt atc 30658 Ser Thr Pro Leu Ala Val Phe Pro Thr Phe Asn Thr Leu Gly Ile 6200 6205 6210 agt ctt gga aac ggt ctt caa act tct aat aag ttg ctg act gta 30703 Ser Leu Gly Asn Gly Leu Gln Thr Ser Asn Lys Leu Leu Thr Val 6215 6220 6225 cag tta act cat cct ctt aca ttc agc tca aat agc atc aca gta 30748 Gln Leu Thr His Pro Leu Thr Phe Ser Ser Asn Ser Ile Thr Val 6230 6235 6240 aaa aca gac aaa gga ctc tat att aat tct agt gga aac aga ggg 30793 Lys Thr Asp Lys Gly Leu Tyr Ile Asn Ser Ser Gly Asn Arg Gly 6245 6250 6255 ctt gag gct aac ata agc cta aaa aga gga ctg att ttt gat ggt 30838 Leu Glu Ala Asn Ile Ser Leu Lys Arg Gly Leu Ile Phe Asp Gly 6260 6265 6270 aat gct att gca aca tac ctt gga agt ggt tta gac tat gga tcc 30883 Asn Ala Ile Ala Thr Tyr Leu Gly Ser Gly Leu Asp Tyr Gly Ser 6275 6280 6285 tat gat agc gat ggg aaa aca aga ccc atc atc acc aaa att gga 30928 Tyr Asp Ser Asp Gly Lys Thr Arg Pro Ile Ile Thr Lys Ile Gly 6290 6295 6300 gca ggt ttg aat ttt gat gct aat aat gcc atg gct gtg aag cta 30973 Ala Gly Leu Asn Phe Asp Ala Asn Asn Ala Met Ala Val Lys Leu 6305 6310 6315 ggc aca ggt tta agt ttt gac tct gcc ggt gcc tta aca gct gga 31018 Gly Thr Gly Leu Ser Phe Asp Ser Ala Gly Ala Leu Thr Ala Gly 6320 6325 6330 aac aaa gag gat gac aag cta aca ctt tgg act aca cct gac cca 31063 Asn Lys Glu Asp Asp Lys Leu Thr Leu Trp Thr Thr Pro Asp Pro 6335 6340 6345 agc cct aat tgt caa tta ctt tca gac aga gat gcc aaa ttt acc 31108 Ser Pro Asn Cys Gln Leu Leu Ser Asp Arg Asp Ala Lys Phe Thr 6350 6355 6360 cta tgt ctt aca aaa tgc ggt agt caa ata cta ggc act gtt gca 31153 Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Ala 6365 6370 6375 gta gct gct gtt act gta ggt tca gca cta aat cca att aat gac 31198 Val Ala Ala Val Thr Val Gly Ser Ala Leu Asn Pro Ile Asn Asp 6380 6385 6390 aca gta aaa agc gcc ata gta ttc ctt aga ttt gac tct gac ggt 31243 Thr Val Lys Ser Ala Ile Val Phe Leu Arg Phe Asp Ser Asp Gly 6395 6400 6405 gtg ctc atg tca aac tca tca atg gta ggt gat tac tgg aac ttt 31288 Val Leu Met Ser Asn Ser Ser Met Val Gly Asp Tyr Trp Asn Phe 6410 6415 6420 agg gaa gga cag acc acc caa agt gtg gcc tat aca aat gct gtg 31333 Arg Glu Gly Gln Thr Thr Gln Ser Val Ala Tyr Thr Asn Ala Val 6425 6430 6435 gga ttc atg ccc aat cta ggt gca tat cct aaa acc caa agc aaa 31378 Gly Phe Met Pro Asn Leu Gly Ala Tyr Pro Lys Thr Gln Ser Lys 6440 6445 6450 aca cca aaa aat agt ata gta agt cag gta tat tta aat gga gaa 31423 Thr Pro Lys Asn Ser Ile Val Ser Gln Val Tyr Leu Asn Gly Glu 6455 6460 6465 act act atg cca atg aca ctg aca ata act ttc aat ggc act gat 31468 Thr Thr Met Pro Met Thr Leu Thr Ile Thr Phe Asn Gly Thr Asp 6470 6475 6480 gaa aaa gac aca aca cct gtg agc act tac tcc atg act ttt aca 31513 Glu Lys Asp Thr Thr Pro Val Ser Thr Tyr Ser Met Thr Phe Thr 6485 6490 6495 tgg cag tgg act gga gac tat aag gac aag aat att acc ttt gct 31558 Trp Gln Trp Thr Gly Asp Tyr Lys Asp Lys Asn Ile Thr Phe Ala 6500 6505 6510 acc aac tcc ttt act ttc tcc tac atg gcc caa gaa taaaccctgc 31604 Thr Asn Ser Phe Thr Phe Ser Tyr Met Ala Gln Glu 6515 6520 6525 atgccaaccc cattgttccc accactatgg aaaactctga agcagaaaaa aataaagttc 31664 aagtgtttta ttgattcaac agttttcaca gaattcgagt agttattttc cctcctccct 31724 cccaactcat ggaatacacc accctctccc cacgcacagc cttaaacatc tgaatgccat 31784 tggtaatgga catggttttg gtctccacat tccacacagt ttcagagcga gccagtctcg 31844 ggtcggtcag ggagatgaaa ccctccgggc actcctgcat ctgcacctca aagttcagta 31904 gctgagggct gtcctcggtg gtcgggatca cagtta tct gga aga aga gcg gtg 31958 Ser Gly Arg Arg Ala Val 6530 aga gtc ata atc cgc gaa cgg gat cgg gcg gtt gtg gcg cat cag 32003 Arg Val Ile Ile Arg Glu Arg Asp Arg Ala Val Val Ala His Gln 6535 6540 6545 gcc ccg cag cag tcg ctg tct gcg ccg ctc cgt caa gct gct gct 32048 Ala Pro Gln Gln Ser Leu Ser Ala Pro Leu Arg Gln Ala Ala Ala 6550 6555 6560 caa ggg gtc tgg gtc cag gga ctc cct gcg cat gat gcc gat ggc 32093 Gln Gly Val Trp Val Gln Gly Leu Pro Ala His Asp Ala Asp Gly 6565 6570 6575 cct gag cat cag tcg cct ggt gcg gcg ggc gca gca gcg gat gcg 32138 Pro Glu His Gln Ser Pro Gly Ala Ala Gly Ala Ala Ala Asp Ala 6580 6585 6590 gat ctc act cag gtc gga gca gta cgt gca gca cag cac tac caa 32183 Asp Leu Thr Gln Val Gly Ala Val Arg Ala Ala Gln His Tyr Gln 6595 6600 6605 gtt gtt caa cag tcc ata gtt caa cgt gct cca gcc aaa act cat 32228 Val Val Gln Gln Ser Ile Val Gln Arg Ala Pro Ala Lys Thr His 6610 6615 6620 ctg tgg aac tat gct gcc cac atg tcc atc gta cca gat cct gat 32273 Leu Trp Asn Tyr Ala Ala His Met Ser Ile Val Pro Asp Pro Asp 6625 6630 6635 gta aat cag gtg gcg ccc cct cca gaa cac act gcc cat gta cat 32318 Val Asn Gln Val Ala Pro Pro Pro Glu His Thr Ala His Val His 6640 6645 6650 gat ctc ctt ggg cat gtg cag gtt cac cac ctc ccg gta cca cat 32363 Asp Leu Leu Gly His Val Gln Val His His Leu Pro Val Pro His 6655 6660 6665 cac ccg ctg gtt gaa cat gca gcc ctg gat aat cct gcg gaa cca 32408 His Pro Leu Val Glu His Ala Ala Leu Asp Asn Pro Ala Glu Pro 6670 6675 6680 gat ggc cag cac cgc ccc gcc cgc cat gca gcg cag gga ccc cgg 32453 Asp Gly Gln His Arg Pro Ala Arg His Ala Ala Gln Gly Pro Arg 6685 6690 6695 gtc ctg gca atg gca gtg gag cac cca ccg ctc acg gcc gtg gat 32498 Val Leu Ala Met Ala Val Glu His Pro Pro Leu Thr Ala Val Asp 6700 6705 6710 taa ctg gga gct gaa caa gtc tat gtt ggc aca gca cag gca cac 32543 Leu Gly Ala Glu Gln Val Tyr Val Gly Thr Ala Gln Ala His 6715 6720 6725 gct cat gca tgt ctt cag cac tct cag ttc ctc ggg ggt cag gac 32588 Ala His Ala Cys Leu Gln His Ser Gln Phe Leu Gly Gly Gln Asp 6730 6735 6740 cat gtc cca ggg cac ggg gaa ctc ttg cag gac agt gaa ccc ggc 32633 His Val Pro Gly His Gly Glu Leu Leu Gln Asp Ser Glu Pro Gly 6745 6750 6755 aga aca ggg cag ccc tcg cac aca act tac att gtg cat gga cag 32678 Arg Thr Gly Gln Pro Ser His Thr Thr Tyr Ile Val His Gly Gln 6760 6765 6770 ggt atc gca atc agg cag cac cgg atg atc ctc cac cag aga agc 32723 Gly Ile Ala Ile Arg Gln His Arg Met Ile Leu His Gln Arg Ser 6775 6780 6785 gcg ggt ctc ggt ctc ctc aca gcg agg taa ggg ggc cgg cgg ttg 32768 Ala Gly Leu Gly Leu Leu Thr Ala Arg Gly Gly Arg Arg Leu 6790 6795 gta cgg atg atg gcg gga tga cgc taa tcg tgt tct gga tcg tgt 32813 Val Arg Met Met Ala Gly Arg Ser Cys Ser Gly Ser Cys 6800 6805 6810 cat gat gga gct gtt tcc tga cat tttcgtactt cacgaagcag aacctggtac 32867 His Asp Gly Ala Val Ser His 6815 gggcactgca caccgctcgc cggcgacggt ctcggcgctt cgagcgctcg gtgttgaagt 32927 tatagaacag ccactccctc agagcgtgca gtatctcctg agcctcttgg gtgatgaaaa 32987 tcccatccgc tctgatggct ctgatcacat cggccacggt ggaatgggcc agacccagcc 33047 agatgatgca attttgttgg gtttcggtga cggagggaga gggaagaaca ggaagaacca 33107 tgattaactt ta ttc caa acg gtc tcg gag cac ttc aaa atg cag gtc 33155 Phe Gln Thr Val Ser Glu His Phe Lys Met Gln Val 6820 6825 6830 ccg gag gtg gca cct ctc gcc ccc act gtg ttg gtg gaa aat aac 33200 Pro Glu Val Ala Pro Leu Ala Pro Thr Val Leu Val Glu Asn Asn 6835 6840 6845 agc cag gtc aaa ggt gac acg gtt ctc gag atg ttc cac ggt ggc 33245 Ser Gln Val Lys Gly Asp Thr Val Leu Glu Met Phe His Gly Gly 6850 6855 6860 ttc cag caa agc ctc cac gcg cac atc cag aaa caa gag gac agc 33290 Phe Gln Gln Ser Leu His Ala His Ile Gln Lys Gln Glu Asp Ser 6865 6870 6875 gaa agc ggg agc gtt ttc taa ttc ctc aat cat cat att aca ctc 33335 Glu Ser Gly Ser Val Phe Phe Leu Asn His His Ile Thr Leu 6880 6885 6890 ctg cac cat ccc cag ata att ttc att ttt cca gcc ttg aat gat 33380 Leu His His Pro Gln Ile Ile Phe Ile Phe Pro Ala Leu Asn Asp 6895 6900 6905 tcg tat tag ttc ctg agg taa atc caa gcc agc cat gat aaa aag ctc 33428 Ser Tyr Phe Leu Arg Ile Gln Ala Ser His Asp Lys Lys Leu 6910 6915 gcg cag agc gcc ctc cac cgg cat tct taa gca cac cct cat 33470 Ala Gln Ser Ala Leu His Arg His Ser Ala His Pro His 6920 6925 6930 aattccaaga gattctgctc ctggttcacc tgcagcagat taacaatggg aatatcaaaa 33530 tctctgccgc gatccctaag ctcctccctc aacaataact gtatgtaatc tttcatatca 33590 tctccgaaat ttttagccat agggccgcca ggaataagag cagggcaagc cacattacag 33650 ataaagcgaa gtcctcccca gtgagcattg ccaaatgtaa gattgaaata agcatgctgg 33710 ctagaccctg tgatatcttc cagataactg gacagaaaat caggcaagca atttttaaga 33770 aaatcaacaa aagaaaagtc gtccaggtgc aggtttagag cctcaggaac aacgatggaa 33830 taagtgcaag gagtgcgttc cagcatggtt agtgtttttt tggtgatctg tagaacaaaa 33890 aataaacatg caatatta aac cat gct agc ctg gcg aac agg tgg gta aat 33941 Asn His Ala Ser Leu Ala Asn Arg Trp Val Asn 6935 6940 cac tct ttc cag cac cag gca ggc tac ggg gtc tcc ggc gcg acc 33986 His Ser Phe Gln His Gln Ala Gly Tyr Gly Val Ser Gly Ala Thr 6945 6950 6955 ctc gta gaa gct gtc gcc atg att gaa aag cat cac cga gag acc 34031 Leu Val Glu Ala Val Ala Met Ile Glu Lys His His Arg Glu Thr 6960 6965 6970 ttc ccg gtg gcc ggc atg gat gat tcg aga aga agc ata cac tcc 34076 Phe Pro Val Ala Gly Met Asp Asp Ser Arg Arg Ser Ile His Ser 6975 6980 6985 ggg aac att ggc atc cgt gag tga aaa aaa gcg acc tat aaa gcc 34121 Gly Asn Ile Gly Ile Arg Glu Lys Lys Ala Thr Tyr Lys Ala 6990 6995 7000 tcg ggg cac tac aat gct caa tct caa ttc cag caa agc cac ccc 34166 Ser Gly His Tyr Asn Ala Gln Ser Gln Phe Gln Gln Ser His Pro 7005 7010 7015 atg cgg atg gag cac aaa att ggc agg tgc gta aaa aat gta att 34211 Met Arg Met Glu His Lys Ile Gly Arg Cys Val Lys Asn Val Ile 7020 7025 7030 act ccc ctc ctg cac agg cag caa agc ccc cgc tcc ctc cag aaa 34256 Thr Pro Leu Leu His Arg Gln Gln Ser Pro Arg Ser Leu Gln Lys 7035 7040 7045 cac ata caa agc ctc agc gtc cat agcttaccga gcacggcagg 34300 His Ile Gln Ser Leu Ser Val His 7050 7055 cgcaagagtc agagaaaagg ctgagctcta acctgactgc ccgctcctgt gctcaatata 34360 tagccctaac ctacactgac gtaaaggcca aagtctaaaa atacccgcca aaatgacaca 34420 cacgcccagc acacgcccag aaaccggtga cacactcaaa aaaatacgtg cgcttcctca 34480 aacgcccaaa ccggcgtcat ttccgggttc ccacgctacg tcaccgctca gcgactttca 34540 aattccgtcg accgttaaaa acgtcactcg ccccgcccct aacggtcgcc cttctctcgg 34600 ccaatcacct tcctcccttc ccaaattcaa acgcctcatt tgcatattaa cgcgcacaaa 34660 aagtttgagg tatattattg atgatgatcg tttaaactat gcggtgtgaa ataccgcaca 34720 gatgcgtaag gagaaaatac cgcatcaggc gctcttccgc ttcctcgctc actgactcgc 34780 tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt 34840 tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg 34900 ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg 34960 agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat 35020 accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta 35080 ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct 35140 gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc 35200 ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa 35260 gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg 35320 taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag 35380 tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt 35440 gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta 35500 cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc 35560 agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca 35620 cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa 35680 cttggtctga cag tta cca atg ctt aat cag tga ggc acc tat ctc agc 35729 Leu Pro Met Leu Asn Gln Gly Thr Tyr Leu Ser 7060 7065 gat ctg tct att tcg ttc atc cat agt tgc ctg act ccc cgt cgt 35774 Asp Leu Ser Ile Ser Phe Ile His Ser Cys Leu Thr Pro Arg Arg 7070 7075 7080 gta gat aac tac gat acg gga ggg ctt acc atc tgg ccc cag tgc 35819 Val Asp Asn Tyr Asp Thr Gly Gly Leu Thr Ile Trp Pro Gln Cys 7085 7090 7095 tgc aat gat acc gcg aga ccc acg ctc acc ggc tcc aga ttt atc 35864 Cys Asn Asp Thr Ala Arg Pro Thr Leu Thr Gly Ser Arg Phe Ile 7100 7105 7110 agc aat aaa cca gcc agc cgg aag ggc cga gcg cag aag tgg tcc 35909 Ser Asn Lys Pro Ala Ser Arg Lys Gly Arg Ala Gln Lys Trp Ser 7115 7120 7125 tgc aac ttt atc cgc ctc cat cca gtc tat taa ttg ttg ccg gga 35954 Cys Asn Phe Ile Arg Leu His Pro Val Tyr Leu Leu Pro Gly 7130 7135 7140 agc tag agt aag tag ttc gcc agt taa tag ttt gcg caa cgt tgt tgc 36002 Ser Ser Lys Phe Ala Ser Phe Ala Gln Arg Cys Cys 7145 7150 cat tgc tgc agg cat cgt ggt gtc acg ctc gtc gtt tgg tat ggc 36047 His Cys Cys Arg His Arg Gly Val Thr Leu Val Val Trp Tyr Gly 7155 7160 7165 ttc att cag ctc cgg ttc cca acg atc aag gcg agt tac atg atc 36092 Phe Ile Gln Leu Arg Phe Pro Thr Ile Lys Ala Ser Tyr Met Ile 7170 7175 7180 ccc cat gtt gtg caa aaa agc ggt tag ctc ctt cgg tcc tcc gat 36137 Pro His Val Val Gln Lys Ser Gly Leu Leu Arg Ser Ser Asp 7185 7190 7195 cgt tgt cag aag taa gtt ggc cgc agt gtt atc act cat ggt tat 36182 Arg Cys Gln Lys Val Gly Arg Ser Val Ile Thr His Gly Tyr 7200 7205 7210 ggc agc act gca taa ttc tct tac tgt cat gcc atc cgt aag atg 36227 Gly Ser Thr Ala Phe Ser Tyr Cys His Ala Ile Arg Lys Met 7215 7220 ctt ttc tgt gac tgg tga gta ctc aac caa gtc att ctg aga ata 36272 Leu Phe Cys Asp Trp Val Leu Asn Gln Val Ile Leu Arg Ile 7225 7230 7235 gtg tat gcg gcg acc gag ttg ctc ttg ccc ggc gtc aac acg gga 36317 Val Tyr Ala Ala Thr Glu Leu Leu Leu Pro Gly Val Asn Thr Gly 7240 7245 7250 taa tac cgc gcc aca tag cag aac ttt aaa agt gct cat cat tgg 36362 Tyr Arg Ala Thr Gln Asn Phe Lys Ser Ala His His Trp 7255 7260 7265 aaa acg ttc ttc ggg gcg aaa act ctc aag gat ctt acc gct gtt 36407 Lys Thr Phe Phe Gly Ala Lys Thr Leu Lys Asp Leu Thr Ala Val 7270 7275 7280 gag atc cag ttc gat gta acc cac tcg tgc acc caa ctg atc ttc 36452 Glu Ile Gln Phe Asp Val Thr His Ser Cys Thr Gln Leu Ile Phe 7285 7290 7295 agc atc ttt tac ttt cac cag cgt ttc tgg gtg agc aaa aac agg 36497 Ser Ile Phe Tyr Phe His Gln Arg Phe Trp Val Ser Lys Asn Arg 7300 7305 7310 aag gca aaa tgc cgc aaa aaa ggg aat aag ggc gac acg gaa atg 36542 Lys Ala Lys Cys Arg Lys Lys Gly Asn Lys Gly Asp Thr Glu Met 7315 7320 7325 ttg aat act cat act cttccttttt caatattatt gaagcattta tcagggttat 36597 Leu Asn Thr His Thr 7330 tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg 36657 cgcacatttc cccgaaaagt gccacctgac gtctaagaaa ccattattat catgacatta 36717 acctataaaa ataggcgtat cacgaggccc tttcgtcttc aagaattgtt taaactacca 36777 tcat 36781 <210> 288 <211> 394 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 288 Met His Pro Val Leu Arg Gln Met Arg Pro His His Pro Pro Pro Gln 1 5 10 15 Gln Gln Pro Pro Pro Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln 20 25 30 Gln Gln Leu Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala Gly 35 40 45 Gln Thr Ser Gln Tyr Asp Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala 50 55 60 Arg Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys 65 70 75 80 Arg Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp 85 90 95 Arg Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ala Arg Phe His Ala 100 105 110 Gly Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp 115 120 125 Glu Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala 130 135 140 His Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys 145 150 155 160 Glu Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu 165 170 175 Ile Ala Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu 180 185 190 Leu Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln 195 200 205 Leu Phe Leu Val Val Gln His Ser Arg Asp Asn Glu Ala Phe Arg Glu 210 215 220 Ala Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu 225 230 235 240 Val Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu 245 250 255 Ser Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys 260 265 270 Tyr Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys 275 280 285 Glu Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu 290 295 300 Thr Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg 305 310 315 320 Ala Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met 325 330 335 His Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser 340 345 350 Tyr Phe Asp Met Gly Ala Asp Leu His Trp Gln Pro Ser Arg Arg Ala 355 360 365 Leu Glu Ala Ala Gly Gly Pro Pro Tyr Ile Glu Glu Val Asp Asp Glu 370 375 380 Val Asp Glu Glu Gly Glu Tyr Leu Glu Asp 385 390 <210> 289 <211> 589 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 289 Met Gln Gln Gln Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu Gln 1 5 10 15 Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala Met 20 25 30 Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg Gln 35 40 45 Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val Pro 50 55 60 Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn Ala 65 70 75 80 Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val Tyr 85 90 95 Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val Gln 100 105 110 Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ala Gln 115 120 125 Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala Leu 130 135 140 Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln Glu 145 150 155 160 Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Thr Glu Val 165 170 175 Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr 180 185 190 Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys Asn 195 200 205 Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala Thr 210 215 220 Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu Val 225 230 235 240 Ala Pro Phe Thr Asp Ser Gly Ser Ile Asn Arg Asn Ser Tyr Leu Gly 245 250 255 Tyr Leu Ile Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp 260 265 270 Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly Gln 275 280 285 Asp Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr Asn 290 295 300 Arg Ser Gln Lys Ile Pro Pro Gln Tyr Thr Leu Ser Ala Glu Glu Glu 305 310 315 320 Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met Gln 325 330 335 Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn Met 340 345 350 Glu Pro Ser Met Tyr Ala Ser Asn Arg Pro Phe Ile Asn Lys Leu Met 355 360 365 Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr Asn 370 375 380 Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr Gly 385 390 395 400 Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp Val 405 410 415 Asp Ser Ser Val Phe Ser Pro Arg Pro Gly Ala Asn Glu Arg Pro Leu 420 425 430 Trp Lys Lys Glu Gly Ser Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly 435 440 445 Arg Glu Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro 450 455 460 Ser Leu Pro Phe Ser Leu Asn Ser Ile Arg Ser Ser Glu Leu Gly Arg 465 470 475 480 Ile Thr Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser 485 490 495 Leu Leu Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu 500 505 510 Ser Leu Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala Gln Glu His 515 520 525 Arg Asp Asp Pro Ser Gln Gly Ala Thr Ser Arg Gly Ser Ala Ala Arg 530 535 540 Lys Arg Arg Trp His Asp Arg Gln Arg Gly Leu Met Trp Asp Asp Glu 545 550 555 560 Asp Ser Ala Asp Asp Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Asn 565 570 575 Pro Phe Ala His Leu Arg Pro Arg Ile Gly Arg Met Met 580 585 <210> 290 <211> 532 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 290 Met Met Arg Arg Ala Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Met Ala Ala Ala Ala Ala Met Gln Pro Pro Leu 20 25 30 Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg 35 40 45 Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg 50 55 60 Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr 65 70 75 80 Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp 85 90 95 Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg 100 105 110 Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro 115 120 125 Asn Val Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met 130 135 140 Val Ser Arg Lys Thr Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln 145 150 155 160 Asp Ile Leu Glu Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn 165 170 175 Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp 180 185 190 Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile 195 200 205 Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val 210 215 220 Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro 225 230 235 240 Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg 245 250 255 Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly 260 265 270 Phe Gln Ile Met Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu 275 280 285 Leu Asp Val Asp Ala Tyr Glu Lys Ser Lys Glu Glu Ser Ala Ala Ala 290 295 300 Ala Thr Ala Ala Val Ala Thr Ala Ser Thr Glu Val Arg Gly Asp Asn 305 310 315 320 Phe Ala Ser Pro Ala Ala Val Ala Ala Ala Glu Ala Ala Glu Thr Glu 325 330 335 Ser Lys Ile Val Ile Gln Pro Val Glu Lys Asp Ser Lys Asp Arg Ser 340 345 350 Tyr Asn Val Leu Pro Asp Lys Ile Asn Thr Ala Tyr Arg Ser Trp Tyr 355 360 365 Leu Ala Tyr Asn Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr 370 375 380 Leu Leu Thr Thr Ser Asp Val Thr Cys Gly Val Glu Gln Val Tyr Trp 385 390 395 400 Ser Leu Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg 405 410 415 Gln Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val Tyr 420 425 430 Ser Lys Ser Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg 435 440 445 Ala Phe Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln 450 455 460 Ile Leu Val Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn 465 470 475 480 Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile 485 490 495 Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys 500 505 510 Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val Ala Pro Arg Val Leu Ser 515 520 525 Ser Arg Thr Phe 530 <210> 291 <211> 193 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 291 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Val Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ala 130 135 140 Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala Ala 145 150 155 160 Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val Arg 165 170 175 Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro Arg 180 185 190 Thr <210> 292 <211> 342 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 292 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Val Val Lys Glu Glu Arg Lys Pro Arg Lys 20 25 30 Ile Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Glu Ser Asp Val Asp 35 40 45 Gly Leu Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln 50 55 60 Trp Arg Gly Arg Lys Val Arg Pro Val Leu Arg Pro Gly Thr Thr Val 65 70 75 80 Val Phe Thr Pro Gly Glu Arg Ser Gly Thr Ala Ser Lys Arg Ser Tyr 85 90 95 Asp Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Ala Glu Arg 100 105 110 Leu Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Ser Ala Pro Lys Glu 115 120 125 Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu 130 135 140 Lys Pro Val Thr Leu Gln Gln Val Leu Pro Thr Ala Ala Pro Arg Arg 145 150 155 160 Gly Phe Lys Arg Glu Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met 165 170 175 Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu Thr Met Lys Val 180 185 190 Asp Pro Asp Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln Val 195 200 205 Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr Glu 210 215 220 Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr Met 225 230 235 240 Glu Val Gln Thr Asp Pro Trp Met Pro Ser Ala Thr Ser Arg Arg Pro 245 250 255 Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn Tyr Ala Leu 260 265 270 His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg Phe Tyr 275 280 285 Arg Gly His Thr Ser Arg Arg Arg Lys Thr Thr Thr Arg Arg Arg Arg 290 295 300 Arg Arg Thr Thr Ala Ala Ala Ser Thr Pro Ala Ala Leu Val Arg Arg 305 310 315 320 Val Tyr Arg Arg Gly Arg Ala Pro Leu Thr Leu Pro Arg Ala Arg Tyr 325 330 335 His Pro Ser Ile Ala Ile 340 <210> 293 <211> 77 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 293 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Ala Gly Asn Gly Met Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 294 <211> 259 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 294 Met Asp Ser Asp Ala Pro Gly Pro Val Met Cys Phe Arg Arg Gln Met 1 5 10 15 Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg Pro 20 25 30 Phe Met Gly Thr Trp Ser Asp Ile Gly Thr Ser Gln Leu Asn Gly Gly 35 40 45 Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser 50 55 60 Thr Leu Lys Thr Tyr Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly Gln 65 70 75 80 Ala Leu Arg Asp Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val Val 85 90 95 Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn Gln 100 105 110 Ala Val Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro Ala 115 120 125 Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu Asp 130 135 140 Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu Leu 145 150 155 160 Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu Gly 165 170 175 Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu Lys 180 185 190 Pro Glu Ser Ser Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Gln Pro 195 200 205 Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val Ala 210 215 220 Arg Ala Arg Pro Gly Gly Thr Ala Arg Pro His Ala Asn Trp Gln Ser 225 230 235 240 Thr Leu Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg Arg 245 250 255 Arg Cys Tyr <210> 295 <211> 931 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 295 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Thr Cys Gln Trp Thr Tyr Thr Asp Lys Gln Thr Glu Lys 130 135 140 Thr Ala Thr Tyr Gly Asn Ala Pro Val Gln Gly Ile Ala Ile Thr Lys 145 150 155 160 Asp Gly Ile Gln Leu Gly Thr Asp Ser Asp Gly Asn Pro Val Tyr Ala 165 170 175 Gln Lys Thr Phe Glu Pro Glu Pro Gln Val Gly Asp Ala Glu Trp His 180 185 190 Asp Thr Thr Gly Thr Asp Glu Lys Tyr Gly Gly Arg Ala Leu Lys Pro 195 200 205 Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys Pro Thr Asn 210 215 220 Lys Glu Gly Gly Gln Ala Lys Asn Arg Thr Lys Thr Asp Gly Thr Gly 225 230 235 240 Glu Glu Pro Asp Ile Asp Met Ala Phe Phe Asp Gly Arg Asn Ala Thr 245 250 255 Thr Ala Gly Leu Ala Pro Glu Ile Val Leu Tyr Thr Glu Asn Val Asp 260 265 270 Leu Glu Thr Pro Asp Thr His Ile Val Tyr Lys Ala Gly Thr Asp Asp 275 280 285 Ser Ser Ser Ser Ile Asn Leu Gly Gln Gln Ser Met Pro Asn Arg Pro 290 295 300 Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn 305 310 315 320 Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn 325 330 335 Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu 340 345 350 Leu Leu Asp Ser Leu Gly Asp Arg Thr Leu Tyr Phe Ser Met Trp Asn 355 360 365 Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His 370 375 380 Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asp Ala Val 385 390 395 400 Gly Arg Thr Asp Thr Tyr Gln Gly Ile Lys Pro Asn Gly Gly Asp Pro 405 410 415 Ala Thr Trp Ala Lys Asp Asp Ser Ala Asn Asp Ala Asn Glu Met Gly 420 425 430 Lys Gly Asn Pro Phe Ala Met Glu Ile Asn Ile Gln Ala Asn Leu Trp 435 440 445 Arg Asn Phe Leu Tyr Ala Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr 450 455 460 Lys Tyr Thr Pro Ala Asn Val Thr Leu Pro Thr Asn Thr Asn Thr Tyr 465 470 475 480 Asp Tyr Met Asn Gly Arg Val Val Ala Pro Ser Leu Val Asp Ser Tyr 485 490 495 Ile Asn Ile Gly Ala Arg Trp Ser Leu Asp Pro Met Asp Asn Val Asn 500 505 510 Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu 515 520 525 Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro Gln Lys 530 535 540 Phe Phe Ala Ile Lys Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr 545 550 555 560 Glu Trp Asn Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu 565 570 575 Gly Asn Asp Leu Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile 580 585 590 Asn Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr 595 600 605 Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp 610 615 620 Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr 625 630 635 640 Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly 645 650 655 Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser 660 665 670 Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp 675 680 685 Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe 690 695 700 Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn 705 710 715 720 Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn Val Ala 725 730 735 Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala His 740 745 750 Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys Asp 755 760 765 Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val 770 775 780 Val Asp Glu Val Asn Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr 785 790 795 800 Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg 805 810 815 Gln Gly Gln Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys 820 825 830 Ser Ala Val Thr Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val 835 840 845 Met Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu 850 855 860 Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu 865 870 875 880 Asp Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr 885 890 895 Val Val Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro His Arg 900 905 910 Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn 915 920 925 Ala Thr Thr 930 <210> 296 <211> 210 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 296 Met Met Ala Glu Ala Ala Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile 1 5 10 15 Ile Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys 20 25 30 Arg Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val 35 40 45 Asn Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala 50 55 60 Trp Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe 65 70 75 80 Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu 85 90 95 Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu 100 105 110 Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu 115 120 125 Phe Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro 130 135 140 Met Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly 145 150 155 160 Met Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu 165 170 175 Ala Leu Tyr Arg Phe Leu Asn Ser His Ser Ala Tyr Phe Arg Ser His 180 185 190 Arg Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Asn Gln 195 200 205 Asp Met 210 <210> 297 <211> 503 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 297 Glu Ile Glu Arg Val Leu Pro Gly Leu Gly Met Ala Arg Gly Gln Gly 1 5 10 15 His Val Ala Glu Leu Val Leu Gly Gln Pro Leu Glu Leu Gly Asp Gln 20 25 30 Gln Phe Arg Gln Arg Gly Val Gly Glu Gly Val Gly Pro Gln Leu Pro 35 40 45 Arg Gln Leu Gln Gly Ala Gln Gln Val Gly Arg Gly Asp Leu Glu Ile 50 55 60 Ala Val Gly Thr Arg Val Leu Arg Ala Arg Val Ala Val His Gly Val 65 70 75 80 Ala Ala Leu Glu His His Gln Gly Arg Val Leu His Ala Arg Gln His 85 90 95 Arg Arg Val Gly Asp Ala Leu His Val Glu Val Leu Gly Val Gly His 100 105 110 Pro Glu Gly Gly His Leu Ala Gly Leu Pro Ser His Ser Gly His Ala 115 120 125 Pro Gly Leu Val Val Ala Ile Ala Val Gln Gly Asp Gln His His Leu 130 135 140 Gly Leu Val Gly Val His Pro Arg Val His Gly Leu His Glu Ser Leu 145 150 155 160 Gln Leu Pro Glu Ser Leu Leu Gly Leu Gly Ser Leu Gly Glu Glu Asp 165 170 175 Pro Ala Gly Leu Ala Arg Glu Leu Val Gly Ser Ala Pro Gly Val Val 180 185 190 His Ala Ala Ala Arg Val Val Val Gly Gln Leu His His Ala Ala Pro 195 200 205 Pro Ala Val Leu Gly Asp Leu Gly Pro Val Gly Val Leu Leu Gln Arg 210 215 220 Ala Leu Pro Val Leu Ala Arg His Ile His Leu Asp His Val Leu Leu 225 230 235 240 Leu Asp His Gly Gly Pro Val Gln Ala Pro Gln Leu Ala Leu Gly Leu 245 250 255 Gly Ala Pro Val Gln Pro Gln Arg Ala Pro Gly Ala Leu Pro Val Leu 260 265 270 Val Gly Asp Leu Gly Met Arg Val His Glu Pro Leu Gln Glu Ala Ala 275 280 285 His His Gly Gly Gln Gly Leu Val Ala Ser Glu Gly Gln Arg Asp Ala 290 295 300 Ala Val Leu Leu Val Asp Val Gln Val Ala Asp Ala Ala Val His Leu 305 310 315 320 Ala Leu Leu Gly His Gln Leu Glu Val Gly Phe Gln Val Gly Leu His 325 330 335 Ala Val Ala Val His Gln Tyr Ser His Asp Phe His Thr Leu Leu Pro 340 345 350 Gly Arg Asp Asp Gly Gln Ala His Arg Val Leu His His His Leu Ser 355 360 365 Thr Ser Ser Arg Gly Gln Gly Val Ala Leu Ile Gln Gly Leu Lys Ala 370 375 380 Pro Leu Ala Val Leu Leu Gly Asp Pro His Arg Gly Val Ala Glu Ala 385 390 395 400 His Gly Arg Gln Leu Leu Leu Gly Leu Pro Phe Val Leu Ala Val Leu 405 410 415 Ala Asp Val Leu Gln Asp His Met Leu Gly Leu Ala Gly Phe Leu Leu 420 425 430 Gly Arg Gln Arg Arg Arg Arg Cys Leu Trp Arg Gly Gly Ala Arg Val 435 440 445 Leu Ala His His Tyr Tyr Leu Phe Leu Phe Val Val Arg Gly His Ala 450 455 460 Ala Val Gly Met Ser Leu Arg Gly Gln Arg Arg Arg Arg Arg Ala Leu 465 470 475 480 Ala Ala Ala Thr Trp Arg Met Ala Gly Arg Ala Pro Ser Ala Ile Gly 485 490 495 Gly Ala Leu Pro Ala Ala Leu 500 <210> 298 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 298 Leu Thr Ser Ser Ala Ala Gly His 1 5 <210> 299 <211> 801 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 299 Met Glu Thr Gln Pro Ser Pro Thr Ser Pro Ser Ala Pro Thr Thr Ala 1 5 10 15 Asp Glu Lys Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro Pro Ser Pro 20 25 30 Ala Thr Ser Asp Ala Ala Ala Val Pro Asp Met Gln Glu Met Glu Glu 35 40 45 Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu Glu 50 55 60 Glu Leu Ala Val Arg Phe Gln Ser Ser Ser Gln Glu Asp Lys Glu Gln 65 70 75 80 Pro Glu Gln Glu Ala Glu Asn Glu Gln Ser Gln Ala Gly Leu Glu His 85 90 95 Asp Gly Asp Tyr Leu His Leu Ser Gly Glu Glu Asp Ala Leu Ile Lys 100 105 110 His Leu Ala Arg Gln Ala Ile Ile Val Lys Asp Ala Leu Leu Asp Arg 115 120 125 Thr Glu Val Pro Leu Ser Val Glu Glu Leu Ser Arg Ala Tyr Glu Leu 130 135 140 Asn Leu Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr 145 150 155 160 Cys Glu Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro 165 170 175 Glu Ala Leu Ala Thr Tyr His Ile Phe Phe Lys Asn Gln Lys Ile Pro 180 185 190 Val Ser Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Phe Asn Leu 195 200 205 Gly Pro Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro 210 215 220 Lys Ile Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala 225 230 235 240 Leu Gln Gly Glu Gly Gly Glu His Glu His His Ser Ala Leu Val Glu 245 250 255 Leu Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu 260 265 270 Leu Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met 275 280 285 Ser Ala Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Ile Ser 290 295 300 Glu Asp Glu Gly Met Gln Asp Ser Glu Asp Gly Lys Pro Val Val Ser 305 310 315 320 Asp Glu Gln Leu Ala Arg Trp Leu Gly Pro Asn Ala Ser Pro Gln Ser 325 330 335 Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr Val 340 345 350 Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu Arg 355 360 365 Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val Arg 370 375 380 Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr 385 390 395 400 Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr 405 410 415 Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr 420 425 430 Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln Gln 435 440 445 Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys 450 455 460 Asn Leu Lys Gly Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser 465 470 475 480 Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg 485 490 495 Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg 500 505 510 Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala 515 520 525 Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro 530 535 540 Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala Tyr 545 550 555 560 His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu Cys 565 570 575 His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys Asn 580 585 590 Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln 595 600 605 Gly Pro Ser Asp Asp Gly Glu Gly Ala Lys Gly Gly Leu Lys Leu Thr 610 615 620 Pro Gly Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp 625 630 635 640 Tyr His Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro 645 650 655 Lys Ala Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala 660 665 670 Gln Leu Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys 675 680 685 Gly Arg Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro 690 695 700 Gly Phe Pro Gln Asp Ala Pro Arg Lys Gln Glu Ala Glu Ser Gly Ala 705 710 715 720 Ala Ala Arg Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Gln Ser Gly 725 730 735 Arg Gly Gly Asp Gly Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly 740 745 750 Gln Pro Ala Arg Gln Ser Gly Gly Arg Arg Gly Gly Gly Arg Gly Gly 755 760 765 Arg Ser Ser Arg Arg Gln Thr Val Val Leu Gly Gly Gly Glu Ser Lys 770 775 780 Gln His Gly Tyr His Leu Arg Ser Gly Ser Gly Ser Arg Ser Ala Pro 785 790 795 800 Gln <210> 300 <211> 227 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 300 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Leu Thr Ala Thr 50 55 60 Pro Arg Asn His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Thr Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Ile Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 301 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 301 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Thr 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Val Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Gln Gln Gly Asn Thr Leu Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asp His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 302 <211> 176 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 302 Met Gly Lys Ile Thr Leu Val Cys Gly Val Leu Val Thr Val Val Leu 1 5 10 15 Ser Ile Leu Gly Gly Gly Ser Ala Ala Val Val Thr Glu Lys Lys Ala 20 25 30 Asp Pro Cys Leu Thr Phe Asn Pro Asp Lys Cys Arg Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Thr Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Ser Val Ala Ile Gln Tyr Lys Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Thr Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Leu His Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Glu His Met Cys Glu Thr Ala Met Phe Met Ser Lys Gln Tyr Gly Met 115 120 125 Trp Pro Pro Arg Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Ala Cys Thr Val Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 303 <211> 247 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 303 Met Arg Leu Leu Ile Phe Val Ile Ile Thr Leu Ser Phe Asn Tyr Ala 1 5 10 15 His Gly Tyr Ala Asn Ile Gln Lys Thr Leu Tyr Val Gly Ser Asp Ser 20 25 30 Thr Leu Glu Gly Thr Gln Ser Gln Ala Arg Val Ser Trp Tyr Phe Tyr 35 40 45 Lys Gly Ser Asp Asp Pro Ile Thr Leu Cys Lys Gly Asp Gln Gly Arg 50 55 60 Ile Thr Lys Pro Pro Ile Thr Phe Ser Cys Thr Arg Thr Asn Leu Thr 65 70 75 80 Leu Leu Ser Ile Thr Lys Glu Tyr Ala Gly Thr Tyr Tyr Ser Thr Asn 85 90 95 Phe His Arg Gly Gln Asp Lys Tyr Tyr Thr Val Lys Val Glu Asn Pro 100 105 110 Thr Thr Pro Arg Thr Thr Thr Lys Pro Thr Thr Thr Lys Lys Pro Thr 115 120 125 Thr Pro Lys Lys Pro Thr Thr Pro Lys Thr Thr Lys Thr Thr Thr Ala 130 135 140 Lys Thr Thr Thr Thr Lys Pro Thr Thr Thr Ser Thr Thr Leu Ala Ile 145 150 155 160 Thr Thr His Thr His Thr Glu Leu Thr Ser Gln Ala Thr Thr Glu Asn 165 170 175 Asp Leu Val Ala Leu Leu Gln Lys Gly Glu Asn Ser Ser Ser Ser Pro 180 185 190 Leu Pro Thr Thr Pro Ser Glu Glu Ile Pro Lys Ser Met Val Gly Ile 195 200 205 Ile Ala Ala Val Val Val Cys Met Leu Ile Ile Ile Leu Cys Met Met 210 215 220 Tyr Tyr Ala Cys Tyr Tyr Arg Lys His Arg Leu Asn Asn Lys Leu Asp 225 230 235 240 Pro Leu Leu Ser Val Asp Phe 245 <210> 304 <211> 291 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 304 Met Lys Ala Leu Ser Thr Leu Val Phe Leu Ser Leu Ile Gly Ile Val 1 5 10 15 Phe Ser Ala Gly Phe Leu Lys Asn Leu Thr Ile Ile Glu Gly Asp Asn 20 25 30 Ala Thr Leu Val Gly Ile Ser Gly Gln Asn Val Ser Trp Leu Lys Tyr 35 40 45 His Leu Asp Gly Trp Lys Pro Ile Cys Thr Trp Asn Val Ser Val Tyr 50 55 60 Thr Cys His Gly Val Asn Leu Thr Ile Thr Asn Ala Thr Gln Asp Gln 65 70 75 80 Asn Gly Arg Phe Lys Gly Gln Ser Phe Thr Ser Asn Asn Gly Tyr Glu 85 90 95 Thr His Asn Met Phe Ile Tyr Asp Val Thr Val Ile Ser Asn Lys Thr 100 105 110 Thr Pro Thr Thr Gln Thr Pro Thr Thr His Ser Ser Thr His Ala Met 115 120 125 Gln Thr Thr Gln Thr Thr Thr Tyr Thr Thr Ser Thr Glu Ser Thr Thr 130 135 140 Thr Thr Thr Ala Glu Val Ser Ser Thr Ala Pro Gln Pro Gln Ala Leu 145 150 155 160 Ala Leu Met Ala Gln Pro Ser Ser Met Thr Ala Lys Thr Asn Glu Gln 165 170 175 Thr Thr Glu Phe Leu Ser Thr Ile Gln Ser Ser Thr Thr Ala Thr Ser 180 185 190 Ser Ala Phe Ser Ser Thr Ala Asn Leu Thr Ser Leu Ser Ser Thr Pro 195 200 205 Ile Ser Asn Ala Thr Thr Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys 210 215 220 Gln Ser Glu Ser Ser Thr Gln Leu Gln Ile Thr Leu Leu Ile Val Ile 225 230 235 240 Gly Val Val Ile Leu Ala Val Leu Leu Tyr Phe Ile Phe Cys Arg Arg 245 250 255 Ile Pro Asn Ala Lys Pro Ala Tyr Lys Pro Ile Val Ile Gly Thr Pro 260 265 270 Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser Phe 275 280 285 Thr Val Trp 290 <210> 305 <211> 149 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 305 Met Ile Ser Met Arg Ala Leu Leu Leu Leu Leu Ala Leu Leu Leu Ala 1 5 10 15 Pro Leu Ala Ala Pro Leu Ser Leu Lys Ser Pro Thr Gln Ser Pro Glu 20 25 30 Glu Val Arg Lys Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Ser Cys 35 40 45 Tyr Lys Leu Lys Ser Glu Met His Pro Ser Trp Ile Met Ile Val Gly 50 55 60 Ile Val Asn Ile Leu Ala Cys Thr Leu Phe Ser Phe Val Ile Tyr Pro 65 70 75 80 Arg Phe Asp Phe Gly Trp Asn Ala Pro Glu Ala Leu Trp Leu Pro Pro 85 90 95 Asp Pro Asp Thr Pro Pro Gln Gln Gln Gln Asn Gln Ala Gln Ala His 100 105 110 Ala Pro Pro Gln Pro Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu 115 120 125 Ala Glu Pro Gln Arg Ala Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu 130 135 140 Thr Gly Gly Asp Asp 145 <210> 306 <211> 490 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 306 Met Phe Ser Val Ser Ser Thr Ser Leu Pro Ser Ser Gln Leu Trp Tyr 1 5 10 15 Cys Arg Pro Arg Arg Ala Ala Asn Phe Leu His Thr Leu Lys Gly Met 20 25 30 Ser Asn Ser Ser Cys Pro Ser Ile Phe Ile Phe Ile Phe Tyr Gln Met 35 40 45 Ser Lys Lys Arg Ala Arg Val Asp Asp Gly Phe Asp Pro Val Tyr Pro 50 55 60 Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro Phe 65 70 75 80 Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser Leu 85 90 95 Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Ala Val Thr Leu Lys 100 105 110 Leu Gly Glu Gly Val Asp Leu Asp Asp Ser Gly Lys Leu Ile Ser Lys 115 120 125 Asn Ala Thr Lys Ala Thr Ala Pro Leu Ser Ile Ser Asn Gly Thr Ile 130 135 140 Ser Leu Asn Met Ala Ala Pro Phe Tyr Asn Asn Asn Gly Thr Leu Ser 145 150 155 160 Leu Asn Val Ser Thr Pro Leu Ala Val Phe Pro Thr Phe Asn Thr Leu 165 170 175 Gly Ile Ser Leu Gly Asn Gly Leu Gln Thr Ser Asn Lys Leu Leu Thr 180 185 190 Val Gln Leu Thr His Pro Leu Thr Phe Ser Ser Asn Ser Ile Thr Val 195 200 205 Lys Thr Asp Lys Gly Leu Tyr Ile Asn Ser Ser Gly Asn Arg Gly Leu 210 215 220 Glu Ala Asn Ile Ser Leu Lys Arg Gly Leu Ile Phe Asp Gly Asn Ala 225 230 235 240 Ile Ala Thr Tyr Leu Gly Ser Gly Leu Asp Tyr Gly Ser Tyr Asp Ser 245 250 255 Asp Gly Lys Thr Arg Pro Ile Ile Thr Lys Ile Gly Ala Gly Leu Asn 260 265 270 Phe Asp Ala Asn Asn Ala Met Ala Val Lys Leu Gly Thr Gly Leu Ser 275 280 285 Phe Asp Ser Ala Gly Ala Leu Thr Ala Gly Asn Lys Glu Asp Asp Lys 290 295 300 Leu Thr Leu Trp Thr Thr Pro Asp Pro Ser Pro Asn Cys Gln Leu Leu 305 310 315 320 Ser Asp Arg Asp Ala Lys Phe Thr Leu Cys Leu Thr Lys Cys Gly Ser 325 330 335 Gln Ile Leu Gly Thr Val Ala Val Ala Ala Val Thr Val Gly Ser Ala 340 345 350 Leu Asn Pro Ile Asn Asp Thr Val Lys Ser Ala Ile Val Phe Leu Arg 355 360 365 Phe Asp Ser Asp Gly Val Leu Met Ser Asn Ser Ser Met Val Gly Asp 370 375 380 Tyr Trp Asn Phe Arg Glu Gly Gln Thr Thr Gln Ser Val Ala Tyr Thr 385 390 395 400 Asn Ala Val Gly Phe Met Pro Asn Leu Gly Ala Tyr Pro Lys Thr Gln 405 410 415 Ser Lys Thr Pro Lys Asn Ser Ile Val Ser Gln Val Tyr Leu Asn Gly 420 425 430 Glu Thr Thr Met Pro Met Thr Leu Thr Ile Thr Phe Asn Gly Thr Asp 435 440 445 Glu Lys Asp Thr Thr Pro Val Ser Thr Tyr Ser Met Thr Phe Thr Trp 450 455 460 Gln Trp Thr Gly Asp Tyr Lys Asp Lys Asn Ile Thr Phe Ala Thr Asn 465 470 475 480 Ser Phe Thr Phe Ser Tyr Met Ala Gln Glu 485 490 <210> 307 <211> 186 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 307 Ser Gly Arg Arg Ala Val Arg Val Ile Ile Arg Glu Arg Asp Arg Ala 1 5 10 15 Val Val Ala His Gln Ala Pro Gln Gln Ser Leu Ser Ala Pro Leu Arg 20 25 30 Gln Ala Ala Ala Gln Gly Val Trp Val Gln Gly Leu Pro Ala His Asp 35 40 45 Ala Asp Gly Pro Glu His Gln Ser Pro Gly Ala Ala Gly Ala Ala Ala 50 55 60 Asp Ala Asp Leu Thr Gln Val Gly Ala Val Arg Ala Ala Gln His Tyr 65 70 75 80 Gln Val Val Gln Gln Ser Ile Val Gln Arg Ala Pro Ala Lys Thr His 85 90 95 Leu Trp Asn Tyr Ala Ala His Met Ser Ile Val Pro Asp Pro Asp Val 100 105 110 Asn Gln Val Ala Pro Pro Pro Glu His Thr Ala His Val His Asp Leu 115 120 125 Leu Gly His Val Gln Val His His Leu Pro Val Pro His His Pro Leu 130 135 140 Val Glu His Ala Ala Leu Asp Asn Pro Ala Glu Pro Asp Gly Gln His 145 150 155 160 Arg Pro Ala Arg His Ala Ala Gln Gly Pro Arg Val Leu Ala Met Ala 165 170 175 Val Glu His Pro Pro Leu Thr Ala Val Asp 180 185 <210> 308 <211> 83 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 308 Leu Gly Ala Glu Gln Val Tyr Val Gly Thr Ala Gln Ala His Ala His 1 5 10 15 Ala Cys Leu Gln His Ser Gln Phe Leu Gly Gly Gln Asp His Val Pro 20 25 30 Gly His Gly Glu Leu Leu Gln Asp Ser Glu Pro Gly Arg Thr Gly Gln 35 40 45 Pro Ser His Thr Thr Tyr Ile Val His Gly Gln Gly Ile Ala Ile Arg 50 55 60 Gln His Arg Met Ile Leu His Gln Arg Ser Ala Gly Leu Gly Leu Leu 65 70 75 80 Thr Ala Arg <210> 309 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 309 Gly Gly Arg Arg Leu Val Arg Met Met Ala Gly 1 5 10 <210> 310 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 310 Ser Cys Ser Gly Ser Cys His Asp Gly Ala Val Ser 1 5 10 <210> 311 <211> 63 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 311 Phe Gln Thr Val Ser Glu His Phe Lys Met Gln Val Pro Glu Val Ala 1 5 10 15 Pro Leu Ala Pro Thr Val Leu Val Glu Asn Asn Ser Gln Val Lys Gly 20 25 30 Asp Thr Val Leu Glu Met Phe His Gly Gly Phe Gln Gln Ser Leu His 35 40 45 Ala His Ile Gln Lys Gln Glu Asp Ser Glu Ser Gly Ser Val Phe 50 55 60 <210> 312 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 312 Phe Leu Asn His His Ile Thr Leu Leu His His Pro Gln Ile Ile Phe 1 5 10 15 Ile Phe Pro Ala Leu Asn Asp Ser Tyr 20 25 <210> 313 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 313 Ile Gln Ala Ser His Asp Lys Lys Leu Ala Gln Ser Ala Leu His Arg 1 5 10 15 His Ser <210> 314 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 314 Ala His Pro His 1 <210> 315 <211> 63 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 315 Asn His Ala Ser Leu Ala Asn Arg Trp Val Asn His Ser Phe Gln His 1 5 10 15 Gln Ala Gly Tyr Gly Val Ser Gly Ala Thr Leu Val Glu Ala Val Ala 20 25 30 Met Ile Glu Lys His His Arg Glu Thr Phe Pro Val Ala Gly Met Asp 35 40 45 Asp Ser Arg Arg Ser Ile His Ser Gly Asn Ile Gly Ile Arg Glu 50 55 60 <210> 316 <211> 60 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 316 Lys Lys Ala Thr Tyr Lys Ala Ser Gly His Tyr Asn Ala Gln Ser Gln 1 5 10 15 Phe Gln Gln Ser His Pro Met Arg Met Glu His Lys Ile Gly Arg Cys 20 25 30 Val Lys Asn Val Ile Thr Pro Leu Leu His Arg Gln Gln Ser Pro Arg 35 40 45 Ser Leu Gln Lys His Ile Gln Ser Leu Ser Val His 50 55 60 <210> 317 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 317 Leu Pro Met Leu Asn Gln 1 5 <210> 318 <211> 75 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 318 Gly Thr Tyr Leu Ser Asp Leu Ser Ile Ser Phe Ile His Ser Cys Leu 1 5 10 15 Thr Pro Arg Arg Val Asp Asn Tyr Asp Thr Gly Gly Leu Thr Ile Trp 20 25 30 Pro Gln Cys Cys Asn Asp Thr Ala Arg Pro Thr Leu Thr Gly Ser Arg 35 40 45 Phe Ile Ser Asn Lys Pro Ala Ser Arg Lys Gly Arg Ala Gln Lys Trp 50 55 60 Ser Cys Asn Phe Ile Arg Leu His Pro Val Tyr 65 70 75 <210> 319 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 319 Leu Leu Pro Gly Ser 1 5 <210> 320 <211> 44 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 320 Phe Ala Gln Arg Cys Cys His Cys Cys Arg His Arg Gly Val Thr Leu 1 5 10 15 Val Val Trp Tyr Gly Phe Ile Gln Leu Arg Phe Pro Thr Ile Lys Ala 20 25 30 Ser Tyr Met Ile Pro His Val Val Gln Lys Ser Gly 35 40 <210> 321 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 321 Leu Leu Arg Ser Ser Asp Arg Cys Gln Lys 1 5 10 <210> 322 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 322 Val Gly Arg Ser Val Ile Thr His Gly Tyr Gly Ser Thr Ala 1 5 10 <210> 323 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 323 Phe Ser Tyr Cys His Ala Ile Arg Lys Met Leu Phe Cys Asp Trp 1 5 10 15 <210> 324 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 324 Val Leu Asn Gln Val Ile Leu Arg Ile Val Tyr Ala Ala Thr Glu Leu 1 5 10 15 Leu Leu Pro Gly Val Asn Thr Gly 20 <210> 325 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 325 Tyr Arg Ala Thr 1 <210> 326 <211> 74 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 326 Gln Asn Phe Lys Ser Ala His His Trp Lys Thr Phe Phe Gly Ala Lys 1 5 10 15 Thr Leu Lys Asp Leu Thr Ala Val Glu Ile Gln Phe Asp Val Thr His 20 25 30 Ser Cys Thr Gln Leu Ile Phe Ser Ile Phe Tyr Phe His Gln Arg Phe 35 40 45 Trp Val Ser Lys Asn Arg Lys Ala Lys Cys Arg Lys Lys Gly Asn Lys 50 55 60 Gly Asp Thr Glu Met Leu Asn Thr His Thr 65 70 <210> 327 <211> 36781 <212> DNA <213> Artificial Sequence <220> <223> p2875 - E1 deleted molecular clone, based on Simian Adenovirus A1337 <220> <221> CDS <222> (23566)..(24117) <223> 22K <220> <221> CDS <222> (25423)..(26058) <223> E3\CR1-alpha <220> <221> CDS <222> (29612)..(30013) <223> E3\14.7K <220> <221> CDS <222> (32743)..(33108) <223> E4\orf4 complement (32743..33108) <220> <221> CDS <222> (33470)..(33856) <223> E4\orf4 complement (33470..33856) <400> 327 caataatata cctcaaactt tttgtgcgcg ttaatatgca aatgaggcgt ttgaatttgg 60 gaagggagga aggtgattgg ccgagagaag ggcgaccgtt aggggcgggg cgagtgacgt 120 tttgatgacg tggccgcgag gaggagccag tttgcaagtt ctcgtgggaa aagtgacgtc 180 aaacgaggtg tggtttgaac acggaaatac tcaattttcc cgcgctctct gacaggaaat 240 gaggtgtttt tgggcggatg caagttaaaa cgggccattt tcgcgcgaaa actgaatgag 300 gaagtgaaaa tctgagtaat ttcgcgttta tggcagggag gagtatttgc cgagggccga 360 gtagactttg accgattacg tgggggtttc gattaccgtg tttttcacct aaatttccgc 420 gtacggtgtc aaagtccggt gtttttacat catttccccg aaaagtgcca cctgacgtaa 480 ctataacggt cctaaggtag cgaaagctca gatctcccga tcccctatgg tgcactctca 540 gtacaatctg ctctgatgcc gcatagttaa gccagtatct gctccctgct tgtgtgttgg 600 aggtcgctga gtagtgcgcg agcaaaattt aagctacaac aaggcaaggc ttgaccgaca 660 attgcatgaa gaatctgctt agggttaggc gttttgcgct gcttcgcgat gtacgggcca 720 gatatacgcg gtacgaaacc gctgatcagc ctcgactgtg ccttctagtt gccagccatc 780 tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct 840 ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg 900 gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg 960 ggatgcggtg ggctctatgg cttctgaggc ggaaagaacc agcagatctg cagatctgaa 1020 ttcatctatg tcgggtgcgg agaaagaggt aatgaaatgg cacatatgct ggccaccgtg 1080 catgtggctt cccatgcccg caagccctgg cccgagttcg agcacaatgt catgaccagg 1140 tgcaatatgc atctggggtc tcgccgaggc atgttcatgc cctaccagtg caacctgaat 1200 tatgtgaagg tgctgctgga gcccgatgcc atgtccagag tgagcctgac gggggtgttt 1260 gacatgaatg tggaggtgtg gaagattctg agatatgatg aatccaagac caggtgccga 1320 gcctgcgagt gcggagggaa gcatgccagg ttccagcccg tgtgtgtgga tgtgacggag 1380 gacctgcgac ccgatcattt ggtgttgtcc tgcaccggga cggagttcgg ttccagcggg 1440 gaagaatctg actagagtga gtagtgttct ggggcggggg aggacctgca tgagggccag 1500 aatgattgaa atctgtgctt ttctgtgtgt tgcagcagca tgagcggaag cggctccttt 1560 gagggagggg tattcagccc ttatctgacg gggcgtctcc cctcctgggc gggagtgcgt 1620 cagaatgtga tgggatccac ggtggacggc cggcccgtgc agcccgcgaa ctcttcaacc 1680 ctgacctatg caaccctgag ctcttcgtcg gtggacgcag ctgccgccgc agctgctgca 1740 tctgccgcca gcgccgtgcg cggaatggcc atgggcgccg gctactacgg cactctggtg 1800 gccaactcga gttccaccaa taatcccgcc agcctgaacg aggagaagct gctgctgctg 1860 atggcccagc tcgaggcctt gacccagcgc ctgggcgagc tgacccagca ggtggctcag 1920 ctgcaggagc agacgcgggc cgcggttgcc acggtgaaat ccaaataaaa aatgaatcaa 1980 taaataaacg gagacggttg ttgattttaa cacagagtct gaatctttat ttgatttttc 2040 gcgcgcggta ggccctggac caccggtctc gatcattgag cactcggtgg atcttttcca 2100 ggacccggta gaggtgggct tggatgttga ggtacatggg catgagcccg tcccgggggt 2160 ggaggtagct ccattgcagg gcctcgtgct cgggggtggt gttgtaaatc acccagtcat 2220 agcaggggcg cagggcatgg tgttgcacaa tatctttgag gaggagactg atggccacgg 2280 gcagcccttt ggtgtaggtg tttacaaatc tgttgagctg ggagggatgc atgcgggggg 2340 agatgaggtg catcttggcc tggatcttga gattggcgat gttaccgccc agatcccgcc 2400 tggggttcat gttgtgcagg accaccagca cggtgtatcc ggtgcacttg gggaatttat 2460 catgcaactt ggaagggaag gcgtgaaaga atttggcgac gcccttgtgc ccgcccaggt 2520 tttccatgca ctcatccatg atgatggcga tggggccgtg ggcggcggcc tgggcaaaaa 2580 cgtttcgggg gtcggacaca tcatagttgt ggtcctgggt gagatcatca taggccattt 2640 taatgaattt ggggcggagg gtgccggact gggggacaaa ggtaccctcg atcccggggg 2700 cgtagttccc ctcacagatc tgcatctccc aggctttgag ctcggagggg gggatcatgt 2760 ccacctgcgg ggcgataaag aacacggttt ccggggcggg agagatgagc tgggccgaaa 2820 gcaagttccg gagcagctgg gacttgccgc agccggtggg gccgtagatg accccgatga 2880 ccggttgcag gtggtagttg agggagagac agctgccgtc ctcccggagg aggggggcca 2940 cctcgttcat catctcgcgc acgtgcatgt tctcgcgcac cagttccgcc aggaggcgct 3000 ctccccccag ggataggagc tcctggagcg aggcgaagtt tttcagcggc ttgagtccgt 3060 cggccatggg cattttggag agggtctgtt gcaagagttc caagcggtcc cagagctcgg 3120 tgatgtgctc tacggcatct cgatccagca gacctcctcg tttcgcgggt tggggcggct 3180 gcgggagtag ggcaccagac gatgggcgtc cagcgcagcc agggtccggt ccttccaggg 3240 tcgcagcgtc cgcgtcaggg tggtctccgt cacggtgaag gggtgcgcgc cgggctgggc 3300 gcttgcgagg gtgcgcttca ggctcatccg gctggtcgaa aaccgctccc gatcggcgcc 3360 ctgcgcgtcg gccaggtagc aattgaccat gagttcgtaa ttgagcgcct cggccgcgtg 3420 acctttggcg cggagcttac ctttggaagt ctgcccgcag gtgggacaga ggagggactt 3480 gagggcgtag agcttggggg cgaggaagac ggactcgggg gcgtaggcgt ccgcgccgca 3540 gtgggcgcag acggtctcgc actccacgag ccaggtgagg tcgggctggt cggggtcaaa 3600 aaccagtttc ccgccgttct ttttgatgcg tttcttacct ttggtctcca tgagctcgtg 3660 tccccgctgg gtgacaaaga ggctgtccgt gtccccgtag accgacttta tgggccggtc 3720 ctcgagcggt gtgccgcggt cctcctcgta gaggaacccc gcccactccg agacgaaagc 3780 ccgggtccag gccagcacga aggaggccac gtgggacggg tagcggtcgt tgtccaccag 3840 cgggtccacc ttctccaggg tatgcaaaca catgtccccc tcgtccacat ccaggaaggt 3900 gattggcttg taagtgtagg ccacgtgacc gggggtccca gccggggggg tataaaaggg 3960 ggcgggcccc tgctcgtcct cactgtcttc cggatcgctg tccaggagcg ccagctgttg 4020 gggtaggtat tccctctcga aggcgggcat gacctcggca ctcaggttgt cagtttctag 4080 aaacgaggag gatttgatat tgacggtgcc ggcggagatg cctttcaaga gcccctcgtc 4140 catctggtca gaaaagacga tctttttgtt gtcgagtttg gtggcgaagg agccgtagag 4200 ggcattggag aggagcttgg cgatagagcg catggtctgg tttttttcct tgtcggcgcg 4260 ctccttggcc gcgatgttga gctgcacgta ctcgcgcgcc acgcacttcc attcggggaa 4320 gacggtggtc agctcgtcgg gcacgattct gacttgccag ccccggttat gcagggtgat 4380 gaggtccaca ctggtgccca cctcgccgcg caggggctcg ttggtccagc agagtcgacc 4440 gcccttgcgc gagcagaagg ggggcagggg gtccagcatg acctcgtcgg gggggtcggc 4500 atcgatggtg aagatgcctg gcaggagatc ggggtcgaag tagctgatgg aagtggccag 4560 atcgtccagg gcagcttgcc attcgcgcac ggccagcgcg cgctcgtagg gactgagggg 4620 cgtgccccaa ggcatggggt gtgtgagcgc ggaggcgtac atgccgcaga tgtcgtagac 4680 gtagaggggc tcctcgagga tgccgatgta ggtggggtaa cagcgccccc cgcggatgct 4740 ggcgcgcacg tagtcataca gctcatgcga gggggcgagg agccccgggc ccaggttggt 4800 gcgactgggc ttttcggcgc ggtagacgat ctggcgaaag atggcatgcg agttggagga 4860 gatggtgggc ctttggaaga tgttgaagtg ggcgtggggc agaccgaccg agtcgcggat 4920 gaagtgggcg taggagtctt gcagtttggc gacgagctcg gcggtgacga ggacgtccag 4980 agcgcagtag tcgagggtct cctggatgat gtcatacttg agctggccct tttgtttcca 5040 cagctcgcgg ttgagaagga actcttcgcg gtccttccag tactcttcga gggggaaccc 5100 gtcctgatct gcacggtaag agcctagcat gtagaactgg ttgacggcct tgtaggcgca 5160 gcagcccttc tccacgggga gggcgtaggc ctgggcggcc ttgcgcaggg aggtgtgcgt 5220 gagggcgaag gtgtccctga ccatgacctt gaggaactgg tgcttgaaat cgatatcgtc 5280 gcagcccccc tgctcccaga gctggaagtc cgtgcgcttc ttgtaggcgg ggttgggcaa 5340 agcgaaagta acatcgttga aaaggatctt gcccgcgcgg ggcataaagt tgcgagtgat 5400 gcggaaaggc tggggcacct cggcccggtt gttgatgacc tgggcggcga gcacgatctc 5460 gtcgaaaccg ttgatgttgt ggcccacgat gtagagttcc acgaatcgcg ggcggccctt 5520 gacgtggggc agcttcttga gctcctcgta ggtgagctcg tcggggtcgc tgagaccgtg 5580 ctgctcgagc gcccagtcgg cgagatgggg gttggcgcgg aggaaggaag tccagagatc 5640 cacggccagg gcggtttgca gacggtcccg gtactgacgg aactgctgcc cgacggccat 5700 tttttcgggg gtgacgcagt agaaggtgcg ggggtccccg tgccagcggt cccatttgag 5760 ctggagggcg agatcgaggg cgagctcgac gaggcggtcg tccccggaga gtttcatgac 5820 cagcatgaag gggacgagct gcttgccgaa ggaccccatc caggtgtagg tttccacatc 5880 gtaggtgagg aagagccttt cggtgcgagg atgcgagccg atggggaaga actggatctc 5940 ctgccaccaa ttggaggaat ggctgttgat gtgatggaag tagaaatgcc gacggcgcgc 6000 cgaacactcg tgcttgtgtt tatacaagcg gccacagtgc tcgcaacgct gcacgggatg 6060 cacgtgctgc acgagctgta cctgagttcc tttgacgagg aatttcagtg ggaagtggag 6120 tcgtggcgcc tgcatctcgt gctgtactac gtcgtggtgg tcggcctggc cctcttctgc 6180 ctcgatggtg gtcatgctga cgagcccgcg cgggaggcag gtccagacct cggcgcgagc 6240 gggtcggaga gcgaggacga gggcgcgcag gccggagctg tccagggtcc tgagacgctg 6300 cggagtcagg tcagtgggca gcggcggcgc gcggttgact tgcaggagtt tttccagggc 6360 gcgcgggagg tccagatggt acttgatctc caccgcgccg ttggtggcga cgtcgatggc 6420 ttgcagggtc ccgtgcccct ggggtgtgac caccgtcccc cgtttcttct tgggcggctg 6480 gggcgacggg ggcggtgcct cttccatggt tagaagcggc ggcgaggacg cgcgccgggc 6540 ggcagaggcg gctcggggcc cggaggcagg ggcggcaggg gcacgtcggc gccgcgcgcg 6600 ggtaggttct ggtactgcgc ccggagaaga ctggcgtgag cgacgacgcg acggttgacg 6660 tcctggatct gacgcctctg ggtgaaggcc acgggacccg tgagtttgaa cctgaaagag 6720 agttcgacag aatcaatctc ggtatcgttg acggcggcct gccgcaggat ctcttgcacg 6780 tcgcccgagt tgtcctggta ggcgatctcg gtcatgaact gctcgatctc ctcctcctga 6840 aggtctccgc ggccggcgcg ctccacggtg gccgcgaggt cgttggagat gcggcccatg 6900 agctgcgaga aggcgttcat gcccgcctcg ttccagacgc ggctgtagac cacgacgccc 6960 tcgggatcgc gggcgcgcat gaccacctgg gcgaggttga gctccacgtg gcgcgtgaag 7020 accgcgtagt tgcagaggcg ctggtagagg tagttgagcg tggtggcgat gtgctcggtg 7080 acgaagaaat acatgatcca gcggcggagc ggcatctcgc tgacgtcgcc cagcgcctcc 7140 aagcgttcca tggcctcgta aaagtccacg gcgaagttga aaaactggga gttgcgcgcc 7200 gagacggtca actcctcctc cagaagacgg atgagctcgg cgatggtggc gcgcacctcg 7260 cgctcgaagg cccccgggag ttcctcctct tccatctcct cttcttcctc ctccactaac 7320 atctcttcta cttcctcctc aggcggtggt ggcgggggag ggggcctgcg tcgccggcgg 7380 cgcacgggca gacggtcgat gaagcgctcg atggtctcgc cgcgccggcg tcgcatggtc 7440 tcggtgacgg cgcgcccgtc ctcgcggggc cgcagcgtga agacgccgcc gcgcatctcc 7500 aggtggccgg gggggtcccc gttgggcagg gagagggcgc tgacgatgca tcttatcaat 7560 tgccccgtag ggactccgcg caaggacctg agcgtctcga gatccacggg atctgaaaac 7620 cgttgaacga aggcttcgag ccagtcgcag tcgcaaggta ggctgagcac ggtttcttct 7680 ggcgggtcat gttggggagc ggggcgggcg atgctgctgg tgatgaagtt gaaataggcg 7740 gttctgagac ggcggatggt ggcgaggagc accaggtctt tgggcccggc ttgctggatg 7800 cgcagacggt cggccatgcc ccaggcgtgg tcctgacacc tggccaggtc cttgtagtag 7860 tcctgcatga gccgctccac gggcacctcc tcctcgcccg cgcggccgtg catgcgcgtg 7920 agcccgaagc cgcgctgggg ctggacgagc gccaggtcgg cgacgacgcg ctcggcgagg 7980 atggcctgct ggatctgggt gagggtggtc tggaagtcgt caaagtcgac gaagcggtgg 8040 taggctccgg tgttgatggt gtaggagcag ttggccatga cggaccagtt gacggtctgg 8100 tggcccggac gcacgagctc gtggtacttg aggcgcgagt aggcgcgcgt gtcgaagatg 8160 tagtcgttgc aggtgcgcac caggtactgg tagccgatga ggaagtgcgg cggcggctgg 8220 cggtagagcg gccatcgctc ggtggcgggg gcgccgggcg cgaggtcctc gagcatggtg 8280 cggtggtagc cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg 8340 cgcgggaact cgcggacgcg gttccagatg ttgcgcagcg gcaggaagta gttcatggtg 8400 ggcacggtct ggcccgtgag gcgcgcgcag tcgtggatgc tctatacggg caaaaacgaa 8460 agcggtcagc ggctcgactc cgtggcctgg aggctaagcg aacgggttgg gctgcgcgtg 8520 taccccggtt cgaatctcga atcaggctgg agccgcagct aacgtggtac tggcactccc 8580 gtctcgaccc aagcctgcac caaccctcca ggatacggag gcgggtcgtt ttgcaacttt 8640 ttttcggagg ccggaaatga agactagtaa gcgcggaaag cggccgaccg cgatggctcg 8700 ctgccgtagt ctggagaaga atcgccaggg ttgcgttgcg gtgtgccccg gttcgaggcc 8760 ggccggattc cgcggctaac gagggcgtgg ctgccccgtc gtttccaaga ccccctagcc 8820 agccgacttc tccagttacg gagcgagccc ctcttttgtt ttgtttgttt ttgccagatg 8880 catcccgtac tgcggcagat gcgcccccac caccctccac cgcaacaaca gccccctcca 8940 cagccggcgc ttctgccccc gccccagcag cagcagcaac ttccagccac gaccgccgcg 9000 gccgccgtga gcggggctgg acagacttct cagtatgacc tggccttgga agagggcgag 9060 gggctggcgc gcctgggggc gtcgtcgccg gagcggcacc cgcgcgtgca gatgaaaagg 9120 gacgctcgcg aggcctacgt gcccaagcag aacctgttca gagacaggag cggcgaggag 9180 cccgaggaga tgcgcgcggc ccggttccac gcggggcggg agctgcggcg cggcctggac 9240 cgaaagaggg tgctgaggga cgaggatttc gaggcggacg agctgacggg gatcagcccc 9300 gcgcgcgcgc acgtggccgc ggccaacctg gtcacggcgt acgagcagac cgtgaaggag 9360 gagagcaact tccaaaaatc cttcaacaac cacgtgcgca ccctgatcgc gcgcgaggag 9420 gtgaccctgg gcctgatgca cctgtgggac ctgctggagg ccatcgtgca gaaccccacc 9480 agcaagccgc tgacggcgca gctgttcctg gtggtgcagc atagtcggga caacgaggcg 9540 ttcagggagg cgctgctgaa tatcaccgag cccgagggcc gctggctcct ggacctggtg 9600 aacattctgc agagcatcgt ggtgcaggag cgcgggctgc cgctgtccga gaagctggcg 9660 gccatcaact tctcggtgct gagtctgggc aagtactacg ctaggaagat ctacaagacc 9720 ccgtacgtgc ccatagacaa ggaggtgaag atcgacgggt tttacatgcg catgaccctg 9780 aaagtgctga ccctgagcga cgatctgggg gtgtaccgca acgacaggat gcaccgcgcg 9840 gtgagcgcca gcaggcggcg cgagctgagc gaccaggagc tgatgcatag tctgcagcgg 9900 gccctgaccg gggccgggac cgagggggag agctactttg acatgggcgc ggacctgcac 9960 tggcagccca gccgccgggc cttggaggcg gcaggcggtc ccccctacat agaagaggtg 10020 gacgatgagg tggacgagga gggcgagtac ctggaagact gatggcgcga ccgtattttt 10080 gctagatgca acaacagcca cctcctgatc ccgcgatgcg ggcggcgctg cagagccagc 10140 cgtccggcat taactcctcg gacgattgga cccaggccat gcaacgcatc atggcgctga 10200 cgacccgcaa ccccgaagcc tttagacagc agccccaggc caaccggctc tcggccatcc 10260 tggaggccgt ggtgccctcg cgctccaacc ccacgcacga gaaggtcctg gccatcgtga 10320 acgcgctggt ggagaacaag gccatccgcg gcgacgaggc cggcctggtg tacaacgcgc 10380 tgctggagcg cgtggcccgc tacaacagca ccaacgtgca gaccaacctg gaccgcatgg 10440 tgaccgacgt gcgcgaggcc gtggcccagc gcgagcggtt ccaccgcgag tccaacctgg 10500 gatccatggt ggcgctgaac gccttcctca gcacccagcc cgccaacgtg ccccggggcc 10560 aggaggacta caccaacttc atcagcgccc tgcgcctgat ggtgaccgag gtgccccaga 10620 gcgaggtgta ccagtccggg ccggactact tcttccagac cagtcgccag ggcttgcaga 10680 ccgtgaacct gagccaggcg ttcaagaact tgcagggcct gtggggcgtg caggccccgg 10740 tcggggaccg cgcgacggtg tcgagcctgc tgacgccgaa ctcgcgcctg ctgctgctgc 10800 tggtggcccc cttcacggac agcggcagca tcaaccgcaa ctcgtacctg ggctacctga 10860 ttaacctgta ccgcgaggcc atcggccagg cgcacgtgga cgagcagacc taccaggaga 10920 tcacccacgt gagccgcgcc ctgggccagg acgacccggg caatctggaa gccaccctga 10980 actttttgct gaccaaccgg tcgcagaaga tcccgcccca gtacacgctc agcgccgagg 11040 aggagcgcat cctgcgatac gtgcagcaga gcgtgggcct gttcctgatg caggaggggg 11100 ccacccccag cgccgcgctc gacatgaccg cgcgcaacat ggagcccagc atgtacgcca 11160 gcaaccgccc gttcatcaat aaactgatgg actacttgca tcgggcggcc gccatgaact 11220 ctgactattt caccaacgcc atcctgaatc cccactggct cccgccgccg gggttctaca 11280 cgggcgagta cgacatgccc gaccccaatg acgggttcct gtgggacgat gtggacagca 11340 gcgtgttctc cccccgaccg ggtgctaacg agcgcccctt gtggaagaag gaaggcagcg 11400 accgacgccc gtcctcggcg ctgtccggcc gcgagggtgc tgccgcggcg gtgcccgagg 11460 ccgccagtcc tttcccgagc ttgcccttct cgctgaacag tattcgcagc agcgagctgg 11520 gcaggatcac gcgcccgcgc ttgctgggcg aggaggagta cttgaatgac tcgctgttga 11580 gacccgagcg ggagaagaac ttccccaata acgggataga gagcctggtg gacaagatga 11640 gccgctggaa gacgtatgcg caggagcaca gggacgatcc gtcgcagggg gccacgagcc 11700 ggggcagcgc cgcccgtaaa cgccggtggc acgacaggca gcggggactg atgtgggacg 11760 atgaggattc cgccgacgac agcagcgtgt tggacttggg tgggagtggt aacccgttcg 11820 ctcacctgcg cccccgcatc gggcgcatga tgtaagagaa accgaaaata aatgatactc 11880 accaaggcca tggcgaccag cgtgcgttcg tttcttctct gttgttgtat ctagtatgat 11940 gaggcgtgcg tacccggagg gtcctcctcc ctcgtacgag agcgtgatgc agcaggcgat 12000 ggcggcggcg gcggcgatgc agcccccgct ggaggctcct tacgtgcccc cgcggtacct 12060 ggcgcctacg gaggggcgga acagcattcg ttactcggag ctggcaccct tgtacgatac 12120 cacccggttg tacctggtgg acaacaagtc ggcggacatc gcctcgctga actaccagaa 12180 cgaccacagc aacttcctga ccaccgtggt gcagaacaat gacttcaccc ccacggaggc 12240 cagcacccag accatcaact ttgacgagcg ctcgcggtgg ggcggtcagc tgaaaaccat 12300 catgcacacc aacatgccca acgtgaacga gttcatgtac agcaacaagt tcaaggcgcg 12360 ggtgatggtc tcccgcaaga cccccaacgg ggtgacagtg acagatggta gtcaggatat 12420 cttggagtat gaatgggtgg agtttgagct gcccgaaggc aacttctcgg tgaccatgac 12480 catcgacctg atgaacaacg ccatcatcga caattacttg gcggtggggc ggcagaacgg 12540 ggtcctggag agcgatatcg gcgtgaagtt cgacactagg aacttcaggc tgggctggga 12600 ccccgtgacc gagctggtca tgcccggggt gtacaccaac gaggccttcc accccgatat 12660 tgtcttgctg cccggctgcg gggtggactt caccgagagc cgcctcagca acctgctggg 12720 cattcgcaag aggcagccct tccaggaggg cttccagatc atgtacgagg atctggaggg 12780 gggcaacatc cccgcgctcc tggatgtcga cgcctatgag aaaagcaagg aggagagcgc 12840 cgccgcggcg actgcagctg tagccaccgc ctctaccgag gtcaggggcg ataattttgc 12900 cagccctgca gcagtggcag cggccgaggc ggctgaaacc gaaagtaaga tagtcattca 12960 gccggtggag aaggatagca aggacaggag ctacaacgtg ctgccggaca agataaacac 13020 cgcctaccgc agctggtacc tggcctacaa ctatggcgac cccgagaagg gcgtgcgctc 13080 ctggacgctg ctcaccacct cggacgtcac ctgcggcgtg gagcaagtct actggtcgct 13140 gcccgacatg atgcaagacc cggtcacctt ccgctccacg cgtcaagtta gcaactaccc 13200 ggtggtgggc gccgagctcc tgcccgtcta ctccaagagc ttcttcaacg agcaggccgt 13260 ctactcgcag cagctgcgcg ccttcacctc gctcacgcac gtcttcaacc gcttccccga 13320 gaaccagatc ctcgtccgcc cgcccgcgcc caccattacc accgtcagtg aaaacgttcc 13380 tgctctcaca gatcacggga ccctgccgct gcgcagcagt atccggggag tccagcgcgt 13440 gaccgttact gacgccagac gccgcacctg cccctacgtc tacaaggccc tgggcatagt 13500 cgcgccgcgc gtcctctcga gccgcacctt ctaaaaaatg tccattctca tctcgcccag 13560 taataacacc ggttggggcc tgcgcgcgcc cagcaagatg tacggaggcg ctcgccaacg 13620 ctccacgcaa caccccgtgc gcgtgcgcgg gcacttccgc gctccctggg gcgccctcaa 13680 gggccgcgtg cggtcgcgca ccaccgtcga cgacgtgatc gaccaggtgg tggccgacgc 13740 gcgcaactac acccccgccg ccgcgcccgt ctccaccgtg gacgccgtca tcgacagcgt 13800 ggtggccgac gcgcgccggt acgcccgcgc caagagccgg cggcggcgca tcgcccggcg 13860 gcaccggagc acccccgcca tgcgcgcggc gcgagccttg ctgcgcaggg ccaggcgcac 13920 gggacgcagg gccatgctca gggcggccag acgcgcggcc tcaggcgcca gcgccggcag 13980 gacccggaga cgcgcggcca cggcggcggc agcggccatc gccagcatgt cccgcccgcg 14040 gcgagggaac gtgtactggg tgcgcgacgc cgccaccggt gtgcgcgtgc ccgtgcgcac 14100 ccgcccccct cgcacttgaa gatgttcact tcgcgatgtt gatgtgtccc agcggcgagg 14160 atgtccaagc gcaaattcaa ggaagagatg ctccaggtca tcgcgcctga gatctacggc 14220 cccgcggtgg tgaaggagga aagaaagccc cgcaaaatca agcgggtcaa aaaggacaaa 14280 aaggaagaag aaagtgatgt ggacggactg gtggagtttg tgcgcgagtt cgccccccgg 14340 cggcgcgtgc agtggcgcgg gcggaaggtg cgcccggtgc tgagaccagg cactacggtg 14400 gtcttcacgc ccggcgagcg ctccggcacc gcttccaagc gctcctacga cgaggtgtac 14460 ggggacgagg acatcctcga gcaggcggcc gagcgcctgg gcgagtttgc ttacggcaag 14520 cgcagccgct ccgcgccgaa ggaagaggcg gtgtccatcc cgctggacca cggcaacccc 14580 acgccgagcc tcaagcccgt gaccctgcag caggtgctgc cgaccgcggc gccgcgccgg 14640 gggttcaagc gcgagggcga ggatctgtac cccaccatgc agctgatggt gcccaagcgc 14700 cagaagctgg aagacgtgct ggagaccatg aaggtggacc cggacgtgca gcccgaggtc 14760 aaggtgcggc ccatcaagca ggtggccccg ggcctgggcg tgcagaccgt ggacatcaag 14820 atccccacgg agcccatgga aacgcagacc gagcccgtga aacccagcac cagcaccatg 14880 gaggtgcaga cggatccttg gatgccatcg gctactagcc gaagaccccg gcgcaagtac 14940 ggcgcggcca gcctgctgat gcccaactac gcgctgcatc cttccatcat ccccacgccg 15000 ggctaccgcg gcacgcgctt ctaccgcggt catacaagcc gccgccgcaa gaccaccacc 15060 cgccgccgcc gtcgccgcac aaccgctgct gcatctaccc ctgccgccct ggtgcggaga 15120 gtgtaccgcc gcggccgcgc gcctctgacc ctgccgcgcg cgcgctacca cccgagcatt 15180 gccatttaaa ctttcgcctg ctttgcagat caatggccct cacatgccgc ctccgcgttc 15240 ccattacggg ctaccgagga agaaaaccgc gccgtagaag gctggcgggg aacgggatgc 15300 gtcgccacca ccaccggcgg cggcgcgcca tcagcaagcg gttgggggga ggcttcctgc 15360 ccgcgctgat ccccatcatc gccgcggcga tcggggcgat ccccggcatt gcttccgtgg 15420 cggtgcaggc ctctcagcgc cactgagaca cacttggaaa catcttgtaa taaaccaatg 15480 gactctgacg ctcctggtcc tgtgatgtgt tttcgtagac agatggaaga catcaatttt 15540 tcgtccctgg ctccgcgaca cggcacgcgg ccgttcatgg gcacctggag cgacatcggc 15600 accagccaac tgaacggggg cgccttcaat tggagcagtc tctggagcgg gcttaagaat 15660 ttcgggtcca cgcttaaaac ctatggcagc aaggcgtgga acagcaccac agggcaggcg 15720 ctgagggata agctgaaaga gcagaacttc cagcagaagg tggtcgatgg cctggcctcg 15780 ggcatcaacg gggtggtgga cctggccaac caggccgtgc agcggcagat caacagccgc 15840 ctggacccgg tgccgcccgc cggctccgtg gagatgccgc aggtggagga ggagctgcct 15900 cccctggaca agcggggcga gaagcgaccc cgccccgacg cggaggagac gctgctgacg 15960 cacacggacg agccgccccc gtacgaggag gcggtgaaac tgggcctgcc caccacgcgg 16020 cccatcgcgc ctctggccac cggggtgctg aaacccgaaa gtagtaagcc cgcgaccctg 16080 gacttgcctc ctccccagcc ttcccgcccc tccacagtgg ctaagcctct gccgccggtg 16140 gccgtggccc gcgcgcgacc cgggggcacc gcccgccctc atgcgaactg gcagagcact 16200 ctgaacagca tcgtgggtct gggagtgcag agtgtgaagc gccgccgctg ctattaaacc 16260 taccgtagcg cttaacttgc ttgtctgtgt gtgtatgtat tatgtcgccg ccgctgtcgc 16320 cagaaggagg agtgaagagg cgcgtcgccg agttgcaaga tggccacccc atcgatgctg 16380 ccccagtggg cgtacatgca catcgccgga caggacgctt cggagtacct gagtccgggt 16440 ctggtgcagt tcgcccgcgc cacagacacc tacttcagtc tggggaacaa gtttaggaac 16500 cccacggtgg cgcccacgca cgatgtgacc accgaccgca gccagcggct gacgctgcgc 16560 ttcgtgcccg tggaccgcga ggacaacacc tactcgtaca aagtgcgcta cacgctggcc 16620 gtgggcgaca accgcgtgct ggacatggcc agcacctact ttgacatccg cggcgtgctg 16680 gaccggggcc ctagcttcaa accctactcc ggcaccgcct acaatgctct ggcccccaag 16740 ggagcaccca acacttgcca gtggacatac acagataagc aaaccgaaaa aacagccacg 16800 tatgggaatg cgcctgtaca aggcattgcc atcacaaaag atggtattca acttggaact 16860 gacagtgatg gaaatcctgt atatgctcaa aagacatttg aacccgaacc tcaagtgggt 16920 gatgcagaat ggcatgacac tacaggtaca gatgaaaagt atggaggcag ggcacttaag 16980 cctgacacca aaatgaagcc ttgctatggt tcttttgcca aacccactaa caaagaaggt 17040 ggacaggcaa agaacagaac aaaaactgat ggaactggcg aagagcctga tattgatatg 17100 gcattttttg acggcagaaa tgcaactaca gctggtttgg ctccagaaat tgttttgtat 17160 actgagaatg tggatctgga gactccagat acccatattg tatacaaagc aggcacagat 17220 gacagcagct cttcgattaa tttggggcag caatccatgc ccaacagacc caactacatt 17280 gggttcagag acaactttat cgggctcatg tactacaaca gcactggcaa tatgggggtg 17340 ctggccggtc aggcttctca gctgaatgct gtggttgact tgcaagacag aaacaccgaa 17400 ctgtcctacc agctcttgct tgactctctg ggcgacagaa ccctgtattt cagtatgtgg 17460 aatcaggcgg tggacagcta tgatcctgat gtgcgcatta ttgaaaacca tggtgtggaa 17520 gatgaacttc ccaactattg cttccctctg gatgctgttg gtaggacaga tacttatcag 17580 ggaattaagc ccaatggagg cgatccagcc acatgggcca aagatgacag cgccaatgat 17640 gctaatgaaa tgggcaaggg caatccattc gccatggaaa tcaacatcca agccaacctg 17700 tggaggaact tcctctacgc caacgtggcc ctgtacctac ccgattctta caagtacacg 17760 ccggccaacg tcaccctgcc caccaacacc aacacctacg attatatgaa cggccgggtg 17820 gtggcgcctt cgctggtgga ctcctacatc aacatcgggg cgcgctggtc gctggacccc 17880 atggacaacg tcaatccctt caaccaccac cgcaacgcgg gcttgcgcta ccgctccatg 17940 ctcctgggca acgggcgcta cgtgcccttc cacatccagg tgccccagaa atttttcgcc 18000 atcaagagcc tcctgctcct gcccgggtcc tacacctacg agtggaactt ccgcaaggac 18060 gtcaacatga tcctgcagag ctccctcggc aacgacctgc gcacggacgg ggcctccatc 18120 tccttcacca gcatcaacct ctacgccacc ttcttcccca tggcgcacaa cacggcctcc 18180 acgctcgagg ccatgctgcg caacgacacc aacgaccagt ccttcaacga ctacctctcg 18240 gcggccaaca tgctctaccc catcccggcc aacgccacca acgtgcccat ctccatcccc 18300 tcgcgcaact gggccgcctt ccgcggctgg tccttcacgc gcctcaagac caaggagacg 18360 ccctcgctgg gctccgggtt cgacccctac ttcgtctact cgggctccat cccctacctc 18420 gacggcacct tctacctcaa ccacaccttc aagaaggtct ccatcacctt cgactcctcc 18480 gtcagctggc ccggcaacga ccggctcctg acgcccaacg agttcgaaat caagcgcacc 18540 gtcgacggcg agggctacaa cgtggcccag tgcaacatga ccaaggactg gttcctggtc 18600 cagatgctgg cccactacaa catcggctac cagggcttct acgtgcccga gggctacaag 18660 gaccgcatgt actccttctt ccgcaacttc cagcccatga gccgccaggt ggtggacgag 18720 gtcaactaca aggactacca ggccgtcacc ctggcctacc agcacaacaa ctcgggcttc 18780 gtcggctacc tcgcgcccac catgcgccag ggccagccct accccgccaa ctacccgtac 18840 ccgctcatcg gcaagagcgc cgtcaccagc gtcacccaga aaaagttcct ctgcgacagg 18900 gtcatgtggc gcatcccctt ctccagcaac ttcatgtcca tgggcgcgct caccgacctc 18960 ggccagaaca tgctctatgc caactccgcc cacgcgctag acatgaattt cgaagtcgac 19020 cccatggatg agtccaccct tctctatgtt gtcttcgaag tcttcgacgt cgtccgagtg 19080 caccagcccc accgcggcgt catcgaggcc gtctacctgc gcaccccctt ctcggccggt 19140 aacgccacca cctaaattgc tacttgcatg atggctgagg ccgcgggctc cggcgagcag 19200 gagctcaggg ccatcatccg cgacctgggc tgcgggccct acttcctggg caccttcgat 19260 aagcgcttcc cgggattcat ggccccgcac aagctggcct gcgccatcgt caacacggcc 19320 ggtcgcgaga ccgggggcga gcactggctg gccttcgcct ggaacccgcg ctcgaacacc 19380 tgctacctct tcgacccctt cgggttctcg gacgagcgcc tcaagcagat ctaccagttc 19440 gagtacgagg gcctgctgcg ccgcagcgcc ctggccaccg aggaccgctg cgtcaccctg 19500 gaaaagtcca cccagaccgt gcagggtccg cgctcggccg cctgcgggct cttctgctgc 19560 atgttcctgc acgccttcgt gcactggccc gaccgcccca tggacaagaa ccccaccatg 19620 aacttgctga cgggggtgcc caacggcatg ctccagtcgc cccaggtgga acccaccctg 19680 cgccgcaacc aggaggcgct ctaccgcttc ctcaactccc actccgccta ctttcgctcc 19740 caccgcgcgc gcatcgagaa ggccaccgcc ttcgatcgca tgaacaatca agacatgtaa 19800 accgtgtgtg tatgtttaaa atatctttta ataaacagca ctttcatgtt acacatgcat 19860 ctgagatgat tatttagaaa tcgaaagggt tctgccgggt ctcggcatgg cccgcgggca 19920 gggacacgtt gcggaactgg tacttggcca gccacttgaa ctcggggatc agcagtttcg 19980 gcagcggggt gtcggggaag gagtcggtcc acagcttccg cgtcagttgc agggcgccca 20040 gcaggtcggg cgcggagatc ttgaaatcgc agttgggacc cgcgttctgc gcgcgagagt 20100 tgcggtacac ggggttgcag cactggaaca ccatcagggc cgggtgcttc acgctcgcca 20160 gcaccgtcgc gtcggtgatg ctctccacgt cgaggtcctc ggcgttggcc atcccgaagg 20220 gggtcatctt gcaggtctgc cttcccatag tgggcacgca cccgggcttg tggttgcaat 20280 cgcagtgcag ggggatcagc atcatctggg cctggtcggc gttcatcccc gggtacatgg 20340 ccttcatgaa agcctccaat tgcctgaaag cctgctgggc cttggctccc tcggtgaaga 20400 agaccccgca ggacttgcta gagaactggt tggtagcgca cccggcgtcg tgcacgcagc 20460 agcgcgcgtc gttgttggcc agctgcacca cgctgcgccc ccagcggttc tgggtgatct 20520 tggcccggtc ggggttctcc ttcagcgcgc gctgcccgtt ctcgctcgcc acatccatct 20580 cgatcatgtg ctccttctgg atcatggtgg tcccgtgcag gcaccgcagc ttgccctcgg 20640 tctcggtgca cccgtgcagc cacagcgcgc acccggtgca ctcccagttc ttgtgggcga 20700 tctgggaatg cgcgtgcacg aacccctgca ggaagcggcc catcatggtg gtcagggtct 20760 tgttgctagt gaaggtcagc gggatgccgc ggtgctcctc gttgatgtac aggtggcaga 20820 tgcggcggta cacctcgccc tgctcgggca tcagctggaa gttggctttc aggtcggtct 20880 ccacgcggta gcggtccatc agtatagtca tgatttccat acccttctcc caggccgaga 20940 cgatgggcag gctcataggg ttcttcacca tcatcttagc actagcagcc gcggccaggg 21000 ggtcgctctc atccagggtc tcaaagctcc gcttgccgtc cttctcggtg atccgcaccg 21060 gggggtagct gaagcccacg gccgccagct cctcctcggc ctgcctttcg tcctcgctgt 21120 cctggctgac gtcctgcagg accacatgct tggtcttgcg gggtttcttc ttgggcggca 21180 gcggcggcgg agatgcttgt ggcgaggggg agcgcgagtt ctcgctcacc actactatct 21240 cttcctcttc gtggtccgag gccacgcggc ggtaggtatg tctcttcggg ggcagaggcg 21300 gaggcgacgg gctctcgccg ccgcgacttg gcggatggct ggcagagccc cttccgcgat 21360 cgggggtgcg ctcccggcgg cgctctgact gacttcctcc gcggccggcc attgtgttct 21420 cctagggagg aacaacaagc atggagactc agccatcgcc aacctcgcca tctgccccca 21480 ccaccgccga cgagaagcag cagaatgaaa gcttaaccgc cccgccgccc agccccgcca 21540 cctccgacgc agccgcggtc ccagacatgc aagagatgga ggaatccatc gagattgacc 21600 tgggctatgt gacgcccgcg gagcacgagg aggagctggc agtgcgcttt caatcgtcaa 21660 gccaggaaga taaagaacag ccagagcagg aagcagaaaa cgagcagagt caggctgggc 21720 tcgagcatga cggcgactac ctccacctga gcggggagga ggacgcgctc atcaagcatc 21780 tggcccggca ggccatcatc gtcaaggatg cgctgctcga ccgcaccgag gtgcccctca 21840 gcgtggagga gctcagccgc gcctacgagc tcaacctctt ctcgccgcgc gtgcccccca 21900 agcgccagcc caacggcacc tgcgagccca acccgcgcct caacttctac ccggtcttcg 21960 cggtgcccga ggccctggcc acctaccaca tctttttcaa gaaccaaaag atccccgtct 22020 cctgtcgcgc caaccgcacc cgcgccgacg ccctcttcaa cctgggcccc ggcgcccgcc 22080 tacctgatat cgcctccttg gaagaggttc ccaagatctt cgagggtctg ggcagcgacg 22140 agactcgggc cgcaaacgct ctgcaaggag aaggaggaga gcatgagcac cacagcgccc 22200 tggtcgagtt ggaaggcgac aacgcgcggc tggcggtgct caaacgcacg gtcgagctga 22260 cccatttcgc ctacccggct ctgaacctgc cccccaaagt catgagcgcg gtcatggacc 22320 aggtgctcat caagcgcgcg tcgcccatct ccgaggacga gggcatgcaa gactccgagg 22380 atggcaagcc cgtggtcagc gacgagcagc tggcccggtg gctgggtcct aatgctagtc 22440 cccagagttt ggaagagcgg cgcaagctca tgatggccgt ggtcctggtg accgtggagc 22500 tggagtgcct gcgccgcttc ttcgccgacg cggagaccct gcgcaaggtc gaggagaacc 22560 tgcactacct cttcaggcac gggttcgtgc gccaggcctg caagatctcc aacgtggagc 22620 tgaccaacct ggtctcctac atgggcatct tgcacgagaa ccgcctgggg cagaacgtgc 22680 tgcacaccac cctgcgcggg gaggcccgcc gcgactacat ccgcgactgc gtctacctct 22740 acctctgcca cacctggcag acgggcatgg gcgtgtggca gcagtgtctg gaggagcaga 22800 acctgaaaga gctctgcaag ctcctgcaga agaacctcaa gggtctgtgg accgggttcg 22860 acgagcggac caccgcctcg gacctggccg acctcatctt ccccgagcgc ctcaggctga 22920 cgctgcgcaa cggcctgccc gactttatga gccaaagcat gttgcaaaac tttcgctctt 22980 tcatcctcga acgctccgga atcctgcccg ccacctgctc cgcgctgccc tcggacttcg 23040 tgccgctgac cttccgcgag tgccccccgc cgctgtggag ccactgctac ctgctgcgcc 23100 tggccaacta cctggcctac cactcggacg tgatcgagga cgtcagcggc gagggcctgc 23160 ttgagtgcca ctgccgctgc aacctctgca cgccgcaccg ctccctggcc tgcaaccccc 23220 agctgctgag cgagacccag atcatcggca ccttcgagtt gcaagggccc agcgatgacg 23280 gcgagggagc caaggggggt ctgaaactca ccccggggct gtggacctcg gcctacttgc 23340 gcaagttcgt gcccgaggac taccatccct tcgagatcag gttctacgag gaccaatccc 23400 agccgcctaa ggccgagctg tcggcctgcg tcatcaccca gggggccatc ctggcccaat 23460 tgcaagccat ccagaaatcc cgccaagaat tcttgctgaa aaagggccgc ggggtctacc 23520 tcgaccccca gaccggtgag gagctcaacc ccggcttccc ccagg atg ccc cga gga 23577 Met Pro Arg Gly 1 aac aag aag ctg aaa gtg gag ctg ccg ccc gtg gag gat ttg gag gaa 23625 Asn Lys Lys Leu Lys Val Glu Leu Pro Pro Val Glu Asp Leu Glu Glu 5 10 15 20 gac tgg gag aac agc agt cag gca gag gag gag atg gag gaa gac tgg 23673 Asp Trp Glu Asn Ser Ser Gln Ala Glu Glu Glu Met Glu Glu Asp Trp 25 30 35 gac agc act cag gca gag gag gac agc ctg caa gac agt ctg gag gaa 23721 Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser Leu Glu Glu 40 45 50 gac gag gag gag gca gag gtg gaa gaa gca gcc gcc gcc aga ccg tcg 23769 Asp Glu Glu Glu Ala Glu Val Glu Glu Ala Ala Ala Ala Arg Pro Ser 55 60 65 tcc tcg gcg ggg gag aaa gca agc agc acg gat acc atc tcc gct ccg 23817 Ser Ser Ala Gly Glu Lys Ala Ser Ser Thr Asp Thr Ile Ser Ala Pro 70 75 80 ggt cgg ggt ccc gct cgg ccc cac agt aga tgg gac gag acc ggg cga 23865 Gly Arg Gly Pro Ala Arg Pro His Ser Arg Trp Asp Glu Thr Gly Arg 85 90 95 100 ttc ccg aac ccc acc atc cag acc ggt aag aag gag cgg cag gga tac 23913 Phe Pro Asn Pro Thr Ile Gln Thr Gly Lys Lys Glu Arg Gln Gly Tyr 105 110 115 aag tcc tgg cgg ggg cac aaa aac gcc atc gtc tcc tgc ttg cag gcc 23961 Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser Cys Leu Gln Ala 120 125 130 tgc ggg ggc aac atc tcc ttc acc agg cgc tac ctg ctc ttc cac cgc 24009 Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu Leu Phe His Arg 135 140 145 ggg gtg aac ttc ccc cgc aac atc ttg cat tac tac cgt cac ctc cac 24057 Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr Arg His Leu His 150 155 160 agc ccc tac tac ttc caa gaa gag gca gca gca gaa aaa gac cag cag 24105 Ser Pro Tyr Tyr Phe Gln Glu Glu Ala Ala Ala Glu Lys Asp Gln Gln 165 170 175 180 aaa acc agc agc tagaaaatcc acagcggcag caggtggact gaggatcgcg 24157 Lys Thr Ser Ser gcgaacgagc cggcgcagac ccgggagctg aggaaccgga tctttcccac cctctatgcc 24217 atcttccagc agagtcgggg gcaggagcag gaactgaaag tcaagaaccg ttctctgcgc 24277 tcgctcaccc gcagttgtct gtatcacaag agcgaagacc aacttcagcg cactctcgag 24337 gacgccgagg ctctcttcaa caagtactgc gcgctcactc ttaaagagta gcccgcgccc 24397 gcccagtcgc agaaaaaggc gggaattacg tcacctgtgc ccttcgccct agccgcctcc 24457 acccatcatg agcaaagaga ttcccacgcc ttacatgtgg agctaccagc cccagatggg 24517 cctggccgcc ggcgccgccc aggactactc cacccgcatg aattggctca gcgccgggcc 24577 cgcgatgatc tcacgggtga atgacatccg cgcccaccga aaccagatac tcctagaaca 24637 gtcagcgctc accgccacgc cccgcaatca cctcaatccg cgtaattggc ccgccgccct 24697 ggtgtaccag gaaattcccc agcccacgac cgtactactt ccgcgagacg cccaggccga 24757 agtccagctg actaactcag gtgtccagct ggcgggcggc gccaccctgt gtcgtcaccg 24817 ccccgctcag ggtataaagc ggctggtgat ccggggcaga ggcacacagc tcaacgacga 24877 ggtggtgagc tcttcgctgg gtctgcgacc tgacggagtc ttccaaatcg ccggatcggg 24937 gagatcttcc ttcacgcctc gtcaggcggt cctgactttg gagagttcgt cctcgcagcc 24997 ccgctcgggc ggcatcggca ctctccagtt cgtggaggag ttcactccct cggtctactt 25057 caaccccttc tccggctccc ccggccacta cccggacgag ttcatcccga actttgacgc 25117 catcagcgag tcggtggacg gctacgattg aatgtcccat ggtggcgcgg ctgacctagc 25177 tcggcttcga cacctggacc actgccgccg ctttcgctgc ttcgctcggg acctcgccga 25237 gttcacctac ttcgagctgc ccgaggagca tcctcagggc ccggcccacg gagtgcggat 25297 cgtcgtcgaa gggggcctag actcccacct gcttcggatc ttcagccagc gcccgatcct 25357 ggtcgagcgc caacagggca acaccctcct gaccctctac tgcatctgcg accaccccgg 25417 cctgc atg aaa gtc ttt gtt gtc tgc tgt gta ctg agt ata ata aaa gct 25467 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala 185 190 195 gag atc agc gac tac tcc gga ctc aac tgt ggt gtt tct gca tcc atc 25515 Glu Ile Ser Asp Tyr Ser Gly Leu Asn Cys Gly Val Ser Ala Ser Ile 200 205 210 215 aac cag tct ctg acc ttc acc ggg aac gag acc gag ctc cag ctc cag 25563 Asn Gln Ser Leu Thr Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln 220 225 230 tgt aag ccc cac aag aag tac ctc acc tgg ctg tac cag ggc tcc ccg 25611 Cys Lys Pro His Lys Lys Tyr Leu Thr Trp Leu Tyr Gln Gly Ser Pro 235 240 245 atc gcc gtt gtt aac cac tgc gac gac gac gga gtc ctg ctg aac ggc 25659 Ile Ala Val Val Asn His Cys Asp Asp Asp Gly Val Leu Leu Asn Gly 250 255 260 ccc gcc aac ctt act ttt tcc acc cgc aga agc aag cta ctg ctc ttc 25707 Pro Ala Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Leu Leu Phe 265 270 275 aga ccc ttc ctc ccc ggg atc tat cag tgc atc tcg gga ccc tgc cat 25755 Arg Pro Phe Leu Pro Gly Ile Tyr Gln Cys Ile Ser Gly Pro Cys His 280 285 290 295 cac acc ttc cac ctg atc ccg aat acc acc tct tcc cca gca ccg ctc 25803 His Thr Phe His Leu Ile Pro Asn Thr Thr Ser Ser Pro Ala Pro Leu 300 305 310 ccc act aac aac caa act aac cac caa cgc cac cgt cga gac ctt tcc 25851 Pro Thr Asn Asn Gln Thr Asn His Gln Arg His Arg Arg Asp Leu Ser 315 320 325 tct gat tct aat acc act acc gga ggt gag ctc cga ggt act aag aag 25899 Ser Asp Ser Asn Thr Thr Thr Gly Gly Glu Leu Arg Gly Thr Lys Lys 330 335 340 tcc tca cct ggg att tat tac ggc ccc tgg gag gtg gtg ggg tta ata 25947 Ser Ser Pro Gly Ile Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile 345 350 355 gct tta ggc tta gta gcg ggt ggg ctt ttg gct ctc tgc tac cta tac 25995 Ala Leu Gly Leu Val Ala Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr 360 365 370 375 ctc cct tgc tgt tcc tac tta gtg gtg ctt tgt tgc tgg ttt aag aaa 26043 Leu Pro Cys Cys Ser Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys 380 385 390 tgg gga aga tca ccc tagtgtgcgg tgtgctggtg acggtggtgc tttcgattct 26098 Trp Gly Arg Ser Pro 395 gggaggggga agcgcggctg tagtgacgga gaagaaggcc gatccctgct tgactttcaa 26158 tcccgataaa tgccggctga gttttcagcc agatggcaat cggtgcacgg tgctgatcaa 26218 gtgcggatgg gaatgcgaga gcgtggcgat ccagtataaa aacaagacgc ggaacaatac 26278 tctcgcgtcc acatggcagc ccggggaccc cgagtggtac accgtctctg tccctggtgc 26338 tgacggctcc ctccacacgg tgaacaacac tttcattttt gagcacatgt gcgaaaccgc 26398 catgttcatg agcaagcagt acggtatgtg gcccccacga aaagagaata tcgtggtctt 26458 ctccatcgct tacagcgcgt gcacggtgct aatcaccgcg atcgtgtgcc tgagcattca 26518 catgctcatc gctattcgcc ccagaaataa tgccgagaaa gagaaacagc cataacacac 26578 ttttttcaca caccttgttt tttacagaca atgcgtctgt taatttttgt tatcattaca 26638 ctcagcttta actatgccca tggctatgca aatatacaaa aaaccctcta tgtaggctct 26698 gactctacat tagaaggtac tcaatctcaa gccagggttt catggtattt ttataaaggc 26758 tctgatgacc caattactct ttgcaaaggt gatcaggggc gcataacaaa gccacctatc 26818 acatttagct gcaccagaac aaacctcacg cttttatcca ttacaaaaga atatgctggc 26878 acttattaca gcacaaattt tcatcgtggg caagataaat attatactgt taaggtagaa 26938 aaccctacca cccctagaac aactacaaag cccaccacaa ctaagaagcc cactacacct 26998 aagaagccta ccacacccaa aaccactaag acaacaactg ctaagaccac taccacaaag 27058 ccaaccacaa ccagcaccac acttgctata actacacaca cacacactga gctgacctca 27118 caggcaacta ctgaaaatga tttggttgcc ctgttgcaaa agggggagaa cagtagcagc 27178 agtcctctgc ctactacccc cagtgaggaa atacccaagt ccatggttgg cattatcgct 27238 gctgtagtgg tgtgtatgct gattatcatc ttgtgcatga tgtactatgc ctgctactac 27298 agaaaacaca ggctgaacaa caaactggac cccttactga gtgttgattt ttaatttttt 27358 agaaccatga agatcctaag cctttttgtt ttttctataa ttattacctc tgctatttgt 27418 gaatcagtgg ataaggacgt tactgtcacc actggctcta attatacact aaaagggcct 27478 tcctcaggta tgctttcgtg gtattgttat tttggaaatg atgataaaca gacagagcta 27538 tgtaactttc agaacggcaa aaccaaaaat tctaaaatag ataactatca atgccagggt 27598 actaatttag tactgatgaa tatcacgaaa gcatatgctg gcagttattc ctgtcctgga 27658 caaaacaccg aggaaatgat tttttacaaa ttaattgtag ttgaccctac tactccagca 27718 ccacccacca caaccaaggc acataccaca gacacacagg aaaccactcc agaggcagaa 27778 gtagcagagt tagcaaagca gattcatgaa gattcatttg ttgccaatac ccccacacac 27838 cccggaccgc aatgtccagg gccattagtc agcggcattg tcggtgtgct ttgcgggtta 27898 gcagttataa tcatctgcat gttcattttt gcttgctgct acagaaggct tcaccgacaa 27958 aaatcagacc cactgctgaa cctctatgtt taatttttga ttttccagag ccatgaaggc 28018 acttagcact ttagtatttt tgtccttgat tggcattgtt ttcagtgctg ggtttttgaa 28078 aaatcttacc attattgaag gtgataatgc aacactggta ggaatcagcg gtcagaatgt 28138 tagttggcta aaatatcatc tagatgggtg gaaacctatt tgcacctgga atgtcagtgt 28198 gtacacatgc catggtgtta acctcaccat taccaatgcc acccaagatc agaatggcag 28258 gtttaagggt cagagtttca ctagcaacaa tgggtatgaa acccataaca tgttcatcta 28318 tgatgtcact gtcatatcaa ataagactac acctaccaca cagacaccca ctacacatag 28378 ctcaactcat gccatgcaga ccactcagac aaccacatac actacatcta ctgagtccac 28438 caccaccact acagcagagg tatccagcac agcgcctcag ccccaggcat tggctttgat 28498 ggctcagcct agcagcatga ctgctaaaac caatgagcag actactgaat ttttgtccac 28558 tattcagagc agcaccacag ctacctcgag tgccttctct agcaccgcca atctcacctc 28618 gctttcctct acgccaatca gtaacgctac tacctccccc gctcctcttc ccactcctct 28678 gaagcaatcc gagtctagca cgcagctgca gatcaccctg ctcattgtga tcggggtggt 28738 catcctggca gtgctgctct actttatctt ctgccgccgc atccccaacg cgaaaccggc 28798 ctacaagccc attgttatcg ggacgccgga gccgcttcag gtggagggag gtctaaggaa 28858 tcttctcttc tcttttacag tatggtgatt tgaactatga ttcctagaca tttcattatc 28918 acttctctaa tctgtgtgct ccaagtctgt gccaccctcg ctctcgtggc taacgcgagt 28978 ccagactgca ttggagcgtt cgcctcctac gtgctctttg ccttcatcac ctgcatctgc 29038 tgctgtagca tagtctgcct gcttatcacc ttcttccagt tcgttgactg ggtctttgtg 29098 cgcatcgcct acctgcgcca ccacccccag taccgcgacc agagagtggc gcaactgttg 29158 agactcatct gatgataagc atgcgggctc tgctactact tctcgcgctt ctgctagctc 29218 ccctcgccgc ccccctatcc ctcaaatccc ccacccagtc ccctgaagag gttcgaaaat 29278 gtaaattcca agaaccctgg aaattccttt catgctacaa actcaaatca gaaatgcacc 29338 ccagctggat catgatcgtt ggaatcgtaa acatccttgc ctgtaccctc ttctcctttg 29398 tgatttaccc ccgctttgac tttgggtgga acgcacccga ggcgctctgg ctcccgcctg 29458 atcccgacac accaccacag cagcagcaaa atcaggcaca ggcacatgca ccaccacagc 29518 ctaggccaca atacatgccc atcttagact atgaggccga gccacagcga gccatgcttc 29578 ctgctattag ttacttcaat ctaaccggcg gag atg act gac ccc atg gcc aac 29632 Met Thr Asp Pro Met Ala Asn 400 aac acc gtc aac gac ctc ctg gac atg gac ggc cgc gcc tcg gag cag 29680 Asn Thr Val Asn Asp Leu Leu Asp Met Asp Gly Arg Ala Ser Glu Gln 405 410 415 cga ctc gcc caa ctc cgc atc cgc cag cag cag gag aga gcc gtc aag 29728 Arg Leu Ala Gln Leu Arg Ile Arg Gln Gln Gln Glu Arg Ala Val Lys 420 425 430 435 gag ctg cag gac gcg gtg gcc atc cac cag tgc aag aga ggc atc ttc 29776 Glu Leu Gln Asp Ala Val Ala Ile His Gln Cys Lys Arg Gly Ile Phe 440 445 450 tgc ctg gtg aag cag gcc aag atc tcc ttc gag gtc acg tcc acc gac 29824 Cys Leu Val Lys Gln Ala Lys Ile Ser Phe Glu Val Thr Ser Thr Asp 455 460 465 cat cgc ctc tcc tac gag ctc ctg cag cag cgc cag aag ttc acc tgc 29872 His Arg Leu Ser Tyr Glu Leu Leu Gln Gln Arg Gln Lys Phe Thr Cys 470 475 480 ctg gtc gga gtc aac ccc atc gtc atc acc cag cag tct ggc gat acc 29920 Leu Val Gly Val Asn Pro Ile Val Ile Thr Gln Gln Ser Gly Asp Thr 485 490 495 aag ggt tgc atc cac tgc tcc tgc gac tcc ccc gag tgc gtt cac acc 29968 Lys Gly Cys Ile His Cys Ser Cys Asp Ser Pro Glu Cys Val His Thr 500 505 510 515 ctg atc aag acc ctc tgc ggc ctc cgc gac ctc ctc ccc atg aac 30013 Leu Ile Lys Thr Leu Cys Gly Leu Arg Asp Leu Leu Pro Met Asn 520 525 530 taatcaacta accccctacc cctttaccct ccagtaaaaa taaagattaa aaatgattga 30073 attgatcaat aaagaatcac ttacttgaaa tctgaaacca ggtctctgtc catgttttct 30133 gtcagcagca cttcactccc ctcttcccaa ctctggtact gcaggccccg gcgggctgca 30193 aacttcctcc acactctgaa ggggatgtca aattcctcct gtccctcaat cttcattttt 30253 atcttctatc agatgtccaa aaagcgcgcg cgggtggatg atggcttcga ccccgtgtac 30313 ccctacgatg cagacaacgc accgactgtg cccttcatca accctccctt cgtctcttca 30373 gatggattcc aagaaaagcc cctgggggtg ttgtccctgc gactggccga ccccgtcacc 30433 accaagaatg gggctgtcac cctcaagctg ggggaggggg tggacctcga cgactcggga 30493 aaactcatct ccaaaaatgc caccaaggcc actgcccctc tcagtatttc caacggcacc 30553 atttccctta acatggccgc ccctttttac aacaacaatg gaacgttaag tctcaatgtt 30613 tctacaccat tagcagtatt tcccactttt aacactttag gtatcagtct tggaaacggt 30673 cttcaaactt ctaataagtt gctgactgta cagttaactc atcctcttac attcagctca 30733 aatagcatca cagtaaaaac agacaaagga ctctatatta attctagtgg aaacagaggg 30793 cttgaggcta acataagcct aaaaagagga ctgatttttg atggtaatgc tattgcaaca 30853 taccttggaa gtggtttaga ctatggatcc tatgatagcg atgggaaaac aagacccatc 30913 atcaccaaaa ttggagcagg tttgaatttt gatgctaata atgccatggc tgtgaagcta 30973 ggcacaggtt taagttttga ctctgccggt gccttaacag ctggaaacaa agaggatgac 31033 aagctaacac tttggactac acctgaccca agccctaatt gtcaattact ttcagacaga 31093 gatgccaaat ttaccctatg tcttacaaaa tgcggtagtc aaatactagg cactgttgca 31153 gtagctgctg ttactgtagg ttcagcacta aatccaatta atgacacagt aaaaagcgcc 31213 atagtattcc ttagatttga ctctgacggt gtgctcatgt caaactcatc aatggtaggt 31273 gattactgga actttaggga aggacagacc acccaaagtg tggcctatac aaatgctgtg 31333 ggattcatgc ccaatctagg tgcatatcct aaaacccaaa gcaaaacacc aaaaaatagt 31393 atagtaagtc aggtatattt aaatggagaa actactatgc caatgacact gacaataact 31453 ttcaatggca ctgatgaaaa agacacaaca cctgtgagca cttactccat gacttttaca 31513 tggcagtgga ctggagacta taaggacaag aatattacct ttgctaccaa ctcctttact 31573 ttctcctaca tggcccaaga ataaaccctg catgccaacc ccattgttcc caccactatg 31633 gaaaactctg aagcagaaaa aaataaagtt caagtgtttt attgattcaa cagttttcac 31693 agaattcgag tagttatttt ccctcctccc tcccaactca tggaatacac caccctctcc 31753 ccacgcacag ccttaaacat ctgaatgcca ttggtaatgg acatggtttt ggtctccaca 31813 ttccacacag tttcagagcg agccagtctc gggtcggtca gggagatgaa accctccggg 31873 cactcctgca tctgcacctc aaagttcagt agctgagggc tgtcctcggt ggtcgggatc 31933 acagttatct ggaagaagag cggtgagagt cataatccgc gaacgggatc gggcggttgt 31993 ggcgcatcag gccccgcagc agtcgctgtc tgcgccgctc cgtcaagctg ctgctcaagg 32053 ggtctgggtc cagggactcc ctgcgcatga tgccgatggc cctgagcatc agtcgcctgg 32113 tgcggcgggc gcagcagcgg atgcggatct cactcaggtc ggagcagtac gtgcagcaca 32173 gcactaccaa gttgttcaac agtccatagt tcaacgtgct ccagccaaaa ctcatctgtg 32233 gaactatgct gcccacatgt ccatcgtacc agatcctgat gtaaatcagg tggcgccccc 32293 tccagaacac actgcccatg tacatgatct ccttgggcat gtgcaggttc accacctccc 32353 ggtaccacat cacccgctgg ttgaacatgc agccctggat aatcctgcgg aaccagatgg 32413 ccagcaccgc cccgcccgcc atgcagcgca gggaccccgg gtcctggcaa tggcagtgga 32473 gcacccaccg ctcacggccg tggattaact gggagctgaa caagtctatg ttggcacagc 32533 acaggcacac gctcatgcat gtcttcagca ctctcagttc ctcgggggtc aggaccatgt 32593 cccagggcac ggggaactct tgcaggacag tgaacccggc agaacagggc agccctcgca 32653 cacaacttac attgtgcatg gacagggtat cgcaatcagg cagcaccgga tgatcctcca 32713 ccagagaagc gcgggtctcg gtctcctca cag cga ggt aag ggg gcc ggc ggt 32766 Gln Arg Gly Lys Gly Ala Gly Gly 535 tgg tac gga tga tgg cgg gat gac gct aat cgt gtt ctg gat cgt gtc 32814 Trp Tyr Gly Trp Arg Asp Asp Ala Asn Arg Val Leu Asp Arg Val 540 545 550 atg atg gag ctg ttt cct gac att ttc gta ctt cac gaa gca gaa cct 32862 Met Met Glu Leu Phe Pro Asp Ile Phe Val Leu His Glu Ala Glu Pro 555 560 565 ggt acg ggc act gca cac cgc tcg ccg gcg acg gtc tcg gcg ctt cga 32910 Gly Thr Gly Thr Ala His Arg Ser Pro Ala Thr Val Ser Ala Leu Arg 570 575 580 585 gcg ctc ggt gtt gaa gtt ata gaa cag cca ctc cct cag agc gtg cag 32958 Ala Leu Gly Val Glu Val Ile Glu Gln Pro Leu Pro Gln Ser Val Gln 590 595 600 tat ctc ctg agc ctc ttg ggt gat gaa aat ccc atc cgc tct gat ggc 33006 Tyr Leu Leu Ser Leu Leu Gly Asp Glu Asn Pro Ile Arg Ser Asp Gly 605 610 615 tct gat cac atc ggc cac ggt gga atg ggc cag acc cag cca gat gat 33054 Ser Asp His Ile Gly His Gly Gly Met Gly Gln Thr Gln Pro Asp Asp 620 625 630 gca att ttg ttg ggt ttc ggt gac gga ggg aga ggg aag aac agg aag 33102 Ala Ile Leu Leu Gly Phe Gly Asp Gly Gly Arg Gly Lys Asn Arg Lys 635 640 645 aac cat gattaacttt attccaaacg gtctcggagc acttcaaaat gcaggtcccg 33158 Asn His 650 gaggtggcac ctctcgcccc cactgtgttg gtggaaaata acagccaggt caaaggtgac 33218 acggttctcg agatgttcca cggtggcttc cagcaaagcc tccacgcgca catccagaaa 33278 caagaggaca gcgaaagcgg gagcgttttc taattcctca atcatcatat tacactcctg 33338 caccatcccc agataatttt catttttcca gccttgaatg attcgtatta gttcctgagg 33398 taaatccaag ccagccatga taaaaagctc gcgcagagcg ccctccaccg gcattcttaa 33458 gcacaccctc a taa ttc caa gag att ctg ctc ctg gtt cac ctg cag cag 33508 Phe Gln Glu Ile Leu Leu Leu Val His Leu Gln Gln 655 660 att aac aat ggg aat atc aaa atc tct gcc gcg atc cct aag ctc ctc 33556 Ile Asn Asn Gly Asn Ile Lys Ile Ser Ala Ala Ile Pro Lys Leu Leu 665 670 675 cct caa caa taa ctg tat gta atc ttt cat atc atc tcc gaa att ttt 33604 Pro Gln Gln Leu Tyr Val Ile Phe His Ile Ile Ser Glu Ile Phe 680 685 690 agc cat agg gcc gcc agg aat aag agc agg gca agc cac att aca gat 33652 Ser His Arg Ala Ala Arg Asn Lys Ser Arg Ala Ser His Ile Thr Asp 695 700 705 710 aaa gcg aag tcc tcc cca gtg agc att gcc aaa tgt aag att gaa ata 33700 Lys Ala Lys Ser Ser Pro Val Ser Ile Ala Lys Cys Lys Ile Glu Ile 715 720 725 agc atg ctg gct aga ccc tgt gat atc ttc cag ata act gga cag aaa 33748 Ser Met Leu Ala Arg Pro Cys Asp Ile Phe Gln Ile Thr Gly Gln Lys 730 735 740 atc agg caa gca att ttt aag aaa atc aac aaa aga aaa gtc gtc cag 33796 Ile Arg Gln Ala Ile Phe Lys Lys Ile Asn Lys Arg Lys Val Val Gln 745 750 755 gtg cag gtt tag agc ctc agg aac aac gat gga ata agt gca agg agt 33844 Val Gln Val Ser Leu Arg Asn Asn Asp Gly Ile Ser Ala Arg Ser 760 765 770 gcg ttc cag cat ggttagtgtt tttttggtga tctgtagaac aaaaaataaa 33896 Ala Phe Gln His 775 catgcaatat taaaccatgc tagcctggcg aacaggtggg taaatcactc tttccagcac 33956 caggcaggct acggggtctc cggcgcgacc ctcgtagaag ctgtcgccat gattgaaaag 34016 catcaccgag agaccttccc ggtggccggc atggatgatt cgagaagaag catacactcc 34076 gggaacattg gcatccgtga gtgaaaaaaa gcgacctata aagcctcggg gcactacaat 34136 gctcaatctc aattccagca aagccacccc atgcggatgg agcacaaaat tggcaggtgc 34196 gtaaaaaatg taattactcc cctcctgcac aggcagcaaa gcccccgctc cctccagaaa 34256 cacatacaaa gcctcagcgt ccatagctta ccgagcacgg caggcgcaag agtcagagaa 34316 aaggctgagc tctaacctga ctgcccgctc ctgtgctcaa tatatagccc taacctacac 34376 tgacgtaaag gccaaagtct aaaaataccc gccaaaatga cacacacgcc cagcacacgc 34436 ccagaaaccg gtgacacact caaaaaaata cgtgcgcttc ctcaaacgcc caaaccggcg 34496 tcatttccgg gttcccacgc tacgtcaccg ctcagcgact ttcaaattcc gtcgaccgtt 34556 aaaaacgtca ctcgccccgc ccctaacggt cgcccttctc tcggccaatc accttcctcc 34616 cttcccaaat tcaaacgcct catttgcata ttaacgcgca caaaaagttt gaggtatatt 34676 attgatgatg atcgtttaaa ctatgcggtg tgaaataccg cacagatgcg taaggagaaa 34736 ataccgcatc aggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg 34796 gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg 34856 ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa 34916 ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg 34976 acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc 35036 tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc 35096 ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc 35156 ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg 35216 ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc 35276 actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga 35336 gttcttgaag tggtggccta actacggcta cactagaagg acagtatttg gtatctgcgc 35396 tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac 35456 caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg 35516 atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc 35576 acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa 35636 ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta 35696 ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt 35756 tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag 35816 tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag caataaacca 35876 gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc 35936 tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt 35996 tgttgccatt gctgcaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag 36056 ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt 36116 tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat 36176 ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt 36236 gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc 36296 ttgcccggcg tcaacacggg ataataccgc gccacatagc agaactttaa aagtgctcat 36356 cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag 36416 ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt 36476 ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg 36536 gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta 36596 ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc 36656 gcgcacattt ccccgaaaag tgccacctga cgtctaagaa accattatta tcatgacatt 36716 aacctataaa aataggcgta tcacgaggcc ctttcgtctt caagaattgt ttaaactacc 36776 atcat 36781 <210> 328 <211> 184 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 328 Met Pro Arg Gly Asn Lys Lys Leu Lys Val Glu Leu Pro Pro Val Glu 1 5 10 15 Asp Leu Glu Glu Asp Trp Glu Asn Ser Ser Gln Ala Glu Glu Glu Met 20 25 30 Glu Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp 35 40 45 Ser Leu Glu Glu Asp Glu Glu Glu Ala Glu Val Glu Glu Ala Ala Ala 50 55 60 Ala Arg Pro Ser Ser Ser Ala Gly Glu Lys Ala Ser Ser Thr Asp Thr 65 70 75 80 Ile Ser Ala Pro Gly Arg Gly Pro Ala Arg Pro His Ser Arg Trp Asp 85 90 95 Glu Thr Gly Arg Phe Pro Asn Pro Thr Ile Gln Thr Gly Lys Lys Glu 100 105 110 Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser 115 120 125 Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu 130 135 140 Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr 145 150 155 160 Arg His Leu His Ser Pro Tyr Tyr Phe Gln Glu Glu Ala Ala Ala Glu 165 170 175 Lys Asp Gln Gln Lys Thr Ser Ser 180 <210> 329 <211> 212 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 329 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Asn Cys Gly Val Ser Ala Ser Ile Asn 20 25 30 Gln Ser Leu Thr Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys 35 40 45 Lys Pro His Lys Lys Tyr Leu Thr Trp Leu Tyr Gln Gly Ser Pro Ile 50 55 60 Ala Val Val Asn His Cys Asp Asp Asp Gly Val Leu Leu Asn Gly Pro 65 70 75 80 Ala Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Leu Leu Phe Arg 85 90 95 Pro Phe Leu Pro Gly Ile Tyr Gln Cys Ile Ser Gly Pro Cys His His 100 105 110 Thr Phe His Leu Ile Pro Asn Thr Thr Ser Ser Pro Ala Pro Leu Pro 115 120 125 Thr Asn Asn Gln Thr Asn His Gln Arg His Arg Arg Asp Leu Ser Ser 130 135 140 Asp Ser Asn Thr Thr Thr Gly Gly Glu Leu Arg Gly Thr Lys Lys Ser 145 150 155 160 Ser Pro Gly Ile Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala 165 170 175 Leu Gly Leu Val Ala Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu 180 185 190 Pro Cys Cys Ser Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp 195 200 205 Gly Arg Ser Pro 210 <210> 330 <211> 134 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 330 Met Thr Asp Pro Met Ala Asn Asn Thr Val Asn Asp Leu Leu Asp Met 1 5 10 15 Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg Gln 20 25 30 Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Ala Val Ala Ile His 35 40 45 Gln Cys Lys Arg Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile Ser 50 55 60 Phe Glu Val Thr Ser Thr Asp His Arg Leu Ser Tyr Glu Leu Leu Gln 65 70 75 80 Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val Ile 85 90 95 Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys Asp 100 105 110 Ser Pro Glu Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu Arg 115 120 125 Asp Leu Leu Pro Met Asn 130 <210> 331 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 331 Gln Arg Gly Lys Gly Ala Gly Gly Trp Tyr Gly 1 5 10 <210> 332 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 332 Trp Arg Asp Asp Ala Asn Arg Val Leu Asp Arg Val Met Met Glu Leu 1 5 10 15 Phe Pro Asp Ile Phe Val Leu His Glu Ala Glu Pro Gly Thr Gly Thr 20 25 30 Ala His Arg Ser Pro Ala Thr Val Ser Ala Leu Arg Ala Leu Gly Val 35 40 45 Glu Val Ile Glu Gln Pro Leu Pro Gln Ser Val Gln Tyr Leu Leu Ser 50 55 60 Leu Leu Gly Asp Glu Asn Pro Ile Arg Ser Asp Gly Ser Asp His Ile 65 70 75 80 Gly His Gly Gly Met Gly Gln Thr Gln Pro Asp Asp Ala Ile Leu Leu 85 90 95 Gly Phe Gly Asp Gly Gly Arg Gly Lys Asn Arg Lys Asn His 100 105 110 <210> 333 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 333 Phe Gln Glu Ile Leu Leu Leu Val His Leu Gln Gln Ile Asn Asn Gly 1 5 10 15 Asn Ile Lys Ile Ser Ala Ala Ile Pro Lys Leu Leu Pro Gln Gln 20 25 30 <210> 334 <211> 79 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 334 Leu Tyr Val Ile Phe His Ile Ile Ser Glu Ile Phe Ser His Arg Ala 1 5 10 15 Ala Arg Asn Lys Ser Arg Ala Ser His Ile Thr Asp Lys Ala Lys Ser 20 25 30 Ser Pro Val Ser Ile Ala Lys Cys Lys Ile Glu Ile Ser Met Leu Ala 35 40 45 Arg Pro Cys Asp Ile Phe Gln Ile Thr Gly Gln Lys Ile Arg Gln Ala 50 55 60 Ile Phe Lys Lys Ile Asn Lys Arg Lys Val Val Gln Val Gln Val 65 70 75 <210> 335 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 335 Ser Leu Arg Asn Asn Asp Gly Ile Ser Ala Arg Ser Ala Phe Gln His 1 5 10 15 <210> 336 <211> 38700 <212> DNA <213> Artificial Sequence <220> <223> p2878 - E1 deleted molecular clone with HIVgagshort insertion, based on Simian Adenovirus A1337 <220> <221> repeat_region <222> (1)..(123) <223> ITR <220> <221> enhancer <222> (840)..(1100) <223> Enhancer <220> <221> misc_feature <222> (1101)..(1328) <223> CMV\promoter <220> <221> TATA_signal <222> (1302)..(1305) <223> TATA <220> <221> CDS <222> (1424)..(2515) <223> Gag\short <220> <221> polyA_signal <222> (2668)..(2870) <223> BGH-PolyA (bovine growth hormone (bGH) polyadenylation signal) <220> <221> misc_feature <222> (2957)..(2957) <223> PI-Sce\I\recognition\site <220> <221> misc_feature <222> (3949)..(5570) <223> IVa2 complement (3949..5279, 5559..5570) <220> <221> misc_feature <222> (5559)..(13810) <223> pol complement (5559..8624, 13802..13810) <220> <221> misc_feature <222> (8432)..(13810) <223> pTP complement (8432..10360, 13802..13810) <220> <221> CDS <222> (10797)..(11978) <223> 52K <220> <221> CDS <222> (12005)..(13771) <223> pIIIa <220> <221> CDS <222> (13855)..(15450) <223> penton <220> <221> CDS <222> (15457)..(16035) <223> pVII <220> <221> CDS <222> (16080)..(17105) <223> V <220> <221> CDS <222> (17132)..(17362) <223> pX <220> <221> CDS <222> (17397)..(18173) <223> pVI <220> <221> CDS <222> (18279)..(21071) <223> hexon <220> <221> CDS <222> (21087)..(21716) <223> protease <220> <221> CDS <222> (21796)..(23331) <223> DBP <220> <221> CDS <222> (25485)..(26036) <223> 22K <220> <221> CDS <222> (26384)..(27064) <223> pVIII <220> <221> CDS <222> (27068)..(27385) <223> E3\12.5K <220> <221> CDS <222> (27962)..(28489) <223> E3\gp19K <220> <221> CDS <222> (28528)..(29268) <223> E3\CR1-beta <220> <221> CDS <222> (29284)..(29907) <223> E3\CR1-gamma <220> <221> CDS <222> (29930)..(30802) <223> E3\CR1-delta <220> <221> CDS <222> (31531)..(31932) <223> E3\14.7K <220> <221> CDS <222> (32044)..(33513) <223> fiber <220> <221> misc_feature <222> (33609)..(34936) <223> E4 orf 6/7 complement (33609..33859, 34583..34936) <220> <221> CDS <222> (33860)..(34756) <223> E4/orf6 (compliment 33860..34756) <220> <221> CDS <222> (35039)..(35389) <223> E4/orf3 (compliment 35039..35389) <220> <221> CDS <222> (35828)..(36199) <223> E4/orf1 (compliment 35828..36199) <220> <221> repeat_region <222> (36477)..(36599) <223> ITR <220> <221> misc_feature <222> (36845)..(36851) <223> pMB1\ORI:\low\copy\number complement (36845..36851) <220> <221> misc_feature <222> (36845)..(37442) <223> pMB1\ori complement (36845..37442) <220> <221> rep_origin <222> (36855)..(36855) <223> ORI <220> <221> CDS <222> (37613)..(38476) <223> AP(R) [Note: E-286] complement (37613..38476) <400> 336 caataatata cctcaaactt tttgtgcgcg ttaatatgca aatgaggcgt ttgaatttgg 60 gaagggagga aggtgattgg ccgagagaag ggcgaccgtt aggggcgggg cgagtgacgt 120 tttgatgacg tggccgcgag gaggagccag tttgcaagtt ctcgtgggaa aagtgacgtc 180 aaacgaggtg tggtttgaac acggaaatac tcaattttcc cgcgctctct gacaggaaat 240 gaggtgtttt tgggcggatg caagttaaaa cgggccattt tcgcgcgaaa actgaatgag 300 gaagtgaaaa tctgagtaat ttcgcgttta tggcagggag gagtatttgc cgagggccga 360 gtagactttg accgattacg tgggggtttc gattaccgtg tttttcacct aaatttccgc 420 gtacggtgtc aaagtccggt gtttttacat catttccccg aaaagtgcca cctgacgtaa 480 ctataacggt cctaaggtag cgaaagctca gatctcccga tcccctatgg tgcactctca 540 gtacaatctg ctctgatgcc gcatagttaa gccagtatct gctccctgct tgtgtgttgg 600 aggtcgctga gtagtgcgcg agcaaaattt aagctacaac aaggcaaggc ttgaccgaca 660 attgcatgaa gaatctgctt agggttaggc gttttgcgct gcttcgcgat gtacgggcca 720 gatatacgcg ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat 780 tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg 840 gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa 900 cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact 960 tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta 1020 aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt 1080 acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg 1140 ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg 1200 ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc 1260 cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt 1320 tagtgaaccg tcagatcgcc tggagacgcc atccacgctg ttttgacctc catagaagac 1380 accgggaccg atccagcctc cgcgggcgcg cgtcgacaga gag atg ggt gcg aga 1435 Met Gly Ala Arg 1 gcg tca gta tta agc ggg gga gaa tta gat cga tgg gaa aaa att cgg 1483 Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp Glu Lys Ile Arg 5 10 15 20 tta agg cca ggg gga aag aag aag tac aag cta aag cac atc gta tgg 1531 Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys His Ile Val Trp 25 30 35 gca agc agg gag cta gaa cga ttc gca gtt aat cct ggc ctg tta gaa 1579 Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro Gly Leu Leu Glu 40 45 50 aca tca gaa ggc tgt aga caa ata ctg gga cag cta caa cca tcc ctt 1627 Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu Gln Pro Ser Leu 55 60 65 cag aca gga tca gag gag ctt cga tca cta tac aac aca gta gca acc 1675 Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn Thr Val Ala Thr 70 75 80 ctc tat tgt gtg cac cag cgg atc gag atc aag gac acc aag gaa gct 1723 Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp Thr Lys Glu Ala 85 90 95 100 tta gac aag ata gag gaa gag caa aac aag tcc aag aag aag gcc cag 1771 Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys Lys Lys Ala Gln 105 110 115 cag gca gca gct gac aca gga cac agc aat cag gtc agc caa aat tac 1819 Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val Ser Gln Asn Tyr 120 125 130 cct ata gtg cag aac atc cag ggg caa atg gta cat cag gcc ata tca 1867 Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His Gln Ala Ile Ser 135 140 145 cct aga act tta aat gca tgg gta aaa gta gta gaa gag aag gct ttc 1915 Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu Glu Lys Ala Phe 150 155 160 agc cca gaa gtg ata ccc atg ttt tca gca tta tca gaa gga gcc acc 1963 Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser Glu Gly Ala Thr 165 170 175 180 cca cag gac ctg aac acg atg ttg aac acc gtg ggg gga cat caa gca 2011 Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln Ala 185 190 195 gcc atg caa atg tta aaa gag acc atc aat gag gaa gct gca gaa tgg 2059 Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu Ala Ala Glu Trp 200 205 210 gat aga gtg cat cca gtg cat gca ggg cct att gca cca ggc cag atg 2107 Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala Pro Gly Gln Met 215 220 225 aga gaa cca agg gga agt gac ata gca gga act act agt acc ctt cag 2155 Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Thr Leu Gln 230 235 240 gaa caa ata gga tgg atg aca aat aat cca cct atc cca gta gga gag 2203 Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile Pro Val Gly Glu 245 250 255 260 atc tac aag agg tgg ata atc ctg gga ttg aac aag atc gtg agg atg 2251 Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg Met 265 270 275 tat agc cct acc agc att ctg gac ata aga caa gga cca aaa gaa ccc 2299 Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly Pro Lys Glu Pro 280 285 290 ttt aga gac tat gta gac cgg ttc tat aaa act cta aga gct gag caa 2347 Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu Arg Ala Glu Gln 295 300 305 gct tca cag gag gta aaa aat tgg atg aca gaa acc ttg ttg gtc caa 2395 Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr Leu Leu Val Gln 310 315 320 aat gcg aac cca gat tgt aag acc atc ctg aag gct ctc ggc cca gcg 2443 Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala Leu Gly Pro Ala 325 330 335 340 gct aca cta gaa gaa atg atg aca gca tgt cag gga gta gga gga ccc 2491 Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly Pro 345 350 355 ggc cat aag gca aga gtt ttg tag ggatccacta gttctagact cgaggggggg 2545 Gly His Lys Ala Arg Val Leu 360 cccggtacct ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa 2605 agaaaagggg ggactggaag ggctaattca ctcccaaaga agacaagata aaccgctgat 2665 cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt 2725 ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat 2785 cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg 2845 gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg 2905 aggcggaaag aaccagcaga tctgcagatc tgaattcatc tatgtcgggt gcggagaaag 2965 aggtaatgaa atggcacata tgctggccac cgtgcatgtg gcttcccatg cccgcaagcc 3025 ctggcccgag ttcgagcaca atgtcatgac caggtgcaat atgcatctgg ggtctcgccg 3085 aggcatgttc atgccctacc agtgcaacct gaattatgtg aaggtgctgc tggagcccga 3145 tgccatgtcc agagtgagcc tgacgggggt gtttgacatg aatgtggagg tgtggaagat 3205 tctgagatat gatgaatcca agaccaggtg ccgagcctgc gagtgcggag ggaagcatgc 3265 caggttccag cccgtgtgtg tggatgtgac ggaggacctg cgacccgatc atttggtgtt 3325 gtcctgcacc gggacggagt tcggttccag cggggaagaa tctgactaga gtgagtagtg 3385 ttctggggcg ggggaggacc tgcatgaggg ccagaatgat tgaaatctgt gcttttctgt 3445 gtgttgcagc agcatgagcg gaagcggctc ctttgaggga ggggtattca gcccttatct 3505 gacggggcgt ctcccctcct gggcgggagt gcgtcagaat gtgatgggat ccacggtgga 3565 cggccggccc gtgcagcccg cgaactcttc aaccctgacc tatgcaaccc tgagctcttc 3625 gtcggtggac gcagctgccg ccgcagctgc tgcatctgcc gccagcgccg tgcgcggaat 3685 ggccatgggc gccggctact acggcactct ggtggccaac tcgagttcca ccaataatcc 3745 cgccagcctg aacgaggaga agctgctgct gctgatggcc cagctcgagg ccttgaccca 3805 gcgcctgggc gagctgaccc agcaggtggc tcagctgcag gagcagacgc gggccgcggt 3865 tgccacggtg aaatccaaat aaaaaatgaa tcaataaata aacggagacg gttgttgatt 3925 ttaacacaga gtctgaatct ttatttgatt tttcgcgcgc ggtaggccct ggaccaccgg 3985 tctcgatcat tgagcactcg gtggatcttt tccaggaccc ggtagaggtg ggcttggatg 4045 ttgaggtaca tgggcatgag cccgtcccgg gggtggaggt agctccattg cagggcctcg 4105 tgctcggggg tggtgttgta aatcacccag tcatagcagg ggcgcagggc atggtgttgc 4165 acaatatctt tgaggaggag actgatggcc acgggcagcc ctttggtgta ggtgtttaca 4225 aatctgttga gctgggaggg atgcatgcgg ggggagatga ggtgcatctt ggcctggatc 4285 ttgagattgg cgatgttacc gcccagatcc cgcctggggt tcatgttgtg caggaccacc 4345 agcacggtgt atccggtgca cttggggaat ttatcatgca acttggaagg gaaggcgtga 4405 aagaatttgg cgacgccctt gtgcccgccc aggttttcca tgcactcatc catgatgatg 4465 gcgatggggc cgtgggcggc ggcctgggca aaaacgtttc gggggtcgga cacatcatag 4525 ttgtggtcct gggtgagatc atcataggcc attttaatga atttggggcg gagggtgccg 4585 gactggggga caaaggtacc ctcgatcccg ggggcgtagt tcccctcaca gatctgcatc 4645 tcccaggctt tgagctcgga gggggggatc atgtccacct gcggggcgat aaagaacacg 4705 gtttccgggg cgggagagat gagctgggcc gaaagcaagt tccggagcag ctgggacttg 4765 ccgcagccgg tggggccgta gatgaccccg atgaccggtt gcaggtggta gttgagggag 4825 agacagctgc cgtcctcccg gaggaggggg gccacctcgt tcatcatctc gcgcacgtgc 4885 atgttctcgc gcaccagttc cgccaggagg cgctctcccc ccagggatag gagctcctgg 4945 agcgaggcga agtttttcag cggcttgagt ccgtcggcca tgggcatttt ggagagggtc 5005 tgttgcaaga gttccaagcg gtcccagagc tcggtgatgt gctctacggc atctcgatcc 5065 agcagacctc ctcgtttcgc gggttggggc ggctgcggga gtagggcacc agacgatggg 5125 cgtccagcgc agccagggtc cggtccttcc agggtcgcag cgtccgcgtc agggtggtct 5185 ccgtcacggt gaaggggtgc gcgccgggct gggcgcttgc gagggtgcgc ttcaggctca 5245 tccggctggt cgaaaaccgc tcccgatcgg cgccctgcgc gtcggccagg tagcaattga 5305 ccatgagttc gtaattgagc gcctcggccg cgtgaccttt ggcgcggagc ttacctttgg 5365 aagtctgccc gcaggtggga cagaggaggg acttgagggc gtagagcttg ggggcgagga 5425 agacggactc gggggcgtag gcgtccgcgc cgcagtgggc gcagacggtc tcgcactcca 5485 cgagccaggt gaggtcgggc tggtcggggt caaaaaccag tttcccgccg ttctttttga 5545 tgcgtttctt acctttggtc tccatgagct cgtgtccccg ctgggtgaca aagaggctgt 5605 ccgtgtcccc gtagaccgac tttatgggcc ggtcctcgag cggtgtgccg cggtcctcct 5665 cgtagaggaa ccccgcccac tccgagacga aagcccgggt ccaggccagc acgaaggagg 5725 ccacgtggga cgggtagcgg tcgttgtcca ccagcgggtc caccttctcc agggtatgca 5785 aacacatgtc cccctcgtcc acatccagga aggtgattgg cttgtaagtg taggccacgt 5845 gaccgggggt cccagccggg ggggtataaa agggggcggg cccctgctcg tcctcactgt 5905 cttccggatc gctgtccagg agcgccagct gttggggtag gtattccctc tcgaaggcgg 5965 gcatgacctc ggcactcagg ttgtcagttt ctagaaacga ggaggatttg atattgacgg 6025 tgccggcgga gatgcctttc aagagcccct cgtccatctg gtcagaaaag acgatctttt 6085 tgttgtcgag tttggtggcg aaggagccgt agagggcatt ggagaggagc ttggcgatag 6145 agcgcatggt ctggtttttt tccttgtcgg cgcgctcctt ggccgcgatg ttgagctgca 6205 cgtactcgcg cgccacgcac ttccattcgg ggaagacggt ggtcagctcg tcgggcacga 6265 ttctgacttg ccagccccgg ttatgcaggg tgatgaggtc cacactggtg cccacctcgc 6325 cgcgcagggg ctcgttggtc cagcagagtc gaccgccctt gcgcgagcag aaggggggca 6385 gggggtccag catgacctcg tcgggggggt cggcatcgat ggtgaagatg cctggcagga 6445 gatcggggtc gaagtagctg atggaagtgg ccagatcgtc cagggcagct tgccattcgc 6505 gcacggccag cgcgcgctcg tagggactga ggggcgtgcc ccaaggcatg gggtgtgtga 6565 gcgcggaggc gtacatgccg cagatgtcgt agacgtagag gggctcctcg aggatgccga 6625 tgtaggtggg gtaacagcgc cccccgcgga tgctggcgcg cacgtagtca tacagctcat 6685 gcgagggggc gaggagcccc gggcccaggt tggtgcgact gggcttttcg gcgcggtaga 6745 cgatctggcg aaagatggca tgcgagttgg aggagatggt gggcctttgg aagatgttga 6805 agtgggcgtg gggcagaccg accgagtcgc ggatgaagtg ggcgtaggag tcttgcagtt 6865 tggcgacgag ctcggcggtg acgaggacgt ccagagcgca gtagtcgagg gtctcctgga 6925 tgatgtcata cttgagctgg cccttttgtt tccacagctc gcggttgaga aggaactctt 6985 cgcggtcctt ccagtactct tcgaggggga acccgtcctg atctgcacgg taagagccta 7045 gcatgtagaa ctggttgacg gccttgtagg cgcagcagcc cttctccacg gggagggcgt 7105 aggcctgggc ggccttgcgc agggaggtgt gcgtgagggc gaaggtgtcc ctgaccatga 7165 ccttgaggaa ctggtgcttg aaatcgatat cgtcgcagcc cccctgctcc cagagctgga 7225 agtccgtgcg cttcttgtag gcggggttgg gcaaagcgaa agtaacatcg ttgaaaagga 7285 tcttgcccgc gcggggcata aagttgcgag tgatgcggaa aggctggggc acctcggccc 7345 ggttgttgat gacctgggcg gcgagcacga tctcgtcgaa accgttgatg ttgtggccca 7405 cgatgtagag ttccacgaat cgcgggcggc ccttgacgtg gggcagcttc ttgagctcct 7465 cgtaggtgag ctcgtcgggg tcgctgagac cgtgctgctc gagcgcccag tcggcgagat 7525 gggggttggc gcggaggaag gaagtccaga gatccacggc cagggcggtt tgcagacggt 7585 cccggtactg acggaactgc tgcccgacgg ccattttttc gggggtgacg cagtagaagg 7645 tgcgggggtc cccgtgccag cggtcccatt tgagctggag ggcgagatcg agggcgagct 7705 cgacgaggcg gtcgtccccg gagagtttca tgaccagcat gaaggggacg agctgcttgc 7765 cgaaggaccc catccaggtg taggtttcca catcgtaggt gaggaagagc ctttcggtgc 7825 gaggatgcga gccgatgggg aagaactgga tctcctgcca ccaattggag gaatggctgt 7885 tgatgtgatg gaagtagaaa tgccgacggc gcgccgaaca ctcgtgcttg tgtttataca 7945 agcggccaca gtgctcgcaa cgctgcacgg gatgcacgtg ctgcacgagc tgtacctgag 8005 ttcctttgac gaggaatttc agtgggaagt ggagtcgtgg cgcctgcatc tcgtgctgta 8065 ctacgtcgtg gtggtcggcc tggccctctt ctgcctcgat ggtggtcatg ctgacgagcc 8125 cgcgcgggag gcaggtccag acctcggcgc gagcgggtcg gagagcgagg acgagggcgc 8185 gcaggccgga gctgtccagg gtcctgagac gctgcggagt caggtcagtg ggcagcggcg 8245 gcgcgcggtt gacttgcagg agtttttcca gggcgcgcgg gaggtccaga tggtacttga 8305 tctccaccgc gccgttggtg gcgacgtcga tggcttgcag ggtcccgtgc ccctggggtg 8365 tgaccaccgt cccccgtttc ttcttgggcg gctggggcga cgggggcggt gcctcttcca 8425 tggttagaag cggcggcgag gacgcgcgcc gggcggcaga ggcggctcgg ggcccggagg 8485 caggggcggc aggggcacgt cggcgccgcg cgcgggtagg ttctggtact gcgcccggag 8545 aagactggcg tgagcgacga cgcgacggtt gacgtcctgg atctgacgcc tctgggtgaa 8605 ggccacggga cccgtgagtt tgaacctgaa agagagttcg acagaatcaa tctcggtatc 8665 gttgacggcg gcctgccgca ggatctcttg cacgtcgccc gagttgtcct ggtaggcgat 8725 ctcggtcatg aactgctcga tctcctcctc ctgaaggtct ccgcggccgg cgcgctccac 8785 ggtggccgcg aggtcgttgg agatgcggcc catgagctgc gagaaggcgt tcatgcccgc 8845 ctcgttccag acgcggctgt agaccacgac gccctcggga tcgcgggcgc gcatgaccac 8905 ctgggcgagg ttgagctcca cgtggcgcgt gaagaccgcg tagttgcaga ggcgctggta 8965 gaggtagttg agcgtggtgg cgatgtgctc ggtgacgaag aaatacatga tccagcggcg 9025 gagcggcatc tcgctgacgt cgcccagcgc ctccaagcgt tccatggcct cgtaaaagtc 9085 cacggcgaag ttgaaaaact gggagttgcg cgccgagacg gtcaactcct cctccagaag 9145 acggatgagc tcggcgatgg tggcgcgcac ctcgcgctcg aaggcccccg ggagttcctc 9205 ctcttccatc tcctcttctt cctcctccac taacatctct tctacttcct cctcaggcgg 9265 tggtggcggg ggagggggcc tgcgtcgccg gcggcgcacg ggcagacggt cgatgaagcg 9325 ctcgatggtc tcgccgcgcc ggcgtcgcat ggtctcggtg acggcgcgcc cgtcctcgcg 9385 gggccgcagc gtgaagacgc cgccgcgcat ctccaggtgg ccgggggggt ccccgttggg 9445 cagggagagg gcgctgacga tgcatcttat caattgcccc gtagggactc cgcgcaagga 9505 cctgagcgtc tcgagatcca cgggatctga aaaccgttga acgaaggctt cgagccagtc 9565 gcagtcgcaa ggtaggctga gcacggtttc ttctggcggg tcatgttggg gagcggggcg 9625 ggcgatgctg ctggtgatga agttgaaata ggcggttctg agacggcgga tggtggcgag 9685 gagcaccagg tctttgggcc cggcttgctg gatgcgcaga cggtcggcca tgccccaggc 9745 gtggtcctga cacctggcca ggtccttgta gtagtcctgc atgagccgct ccacgggcac 9805 ctcctcctcg cccgcgcggc cgtgcatgcg cgtgagcccg aagccgcgct ggggctggac 9865 gagcgccagg tcggcgacga cgcgctcggc gaggatggcc tgctggatct gggtgagggt 9925 ggtctggaag tcgtcaaagt cgacgaagcg gtggtaggct ccggtgttga tggtgtagga 9985 gcagttggcc atgacggacc agttgacggt ctggtggccc ggacgcacga gctcgtggta 10045 cttgaggcgc gagtaggcgc gcgtgtcgaa gatgtagtcg ttgcaggtgc gcaccaggta 10105 ctggtagccg atgaggaagt gcggcggcgg ctggcggtag agcggccatc gctcggtggc 10165 gggggcgccg ggcgcgaggt cctcgagcat ggtgcggtgg tagccgtaga tgtacctgga 10225 catccaggtg atgccggcgg cggtggtgga ggcgcgcggg aactcgcgga cgcggttcca 10285 gatgttgcgc agcggcagga agtagttcat ggtgggcacg gtctggcccg tgaggcgcgc 10345 gcagtcgtgg atgctctata cgggcaaaaa cgaaagcggt cagcggctcg actccgtggc 10405 ctggaggcta agcgaacggg ttgggctgcg cgtgtacccc ggttcgaatc tcgaatcagg 10465 ctggagccgc agctaacgtg gtactggcac tcccgtctcg acccaagcct gcaccaaccc 10525 tccaggatac ggaggcgggt cgttttgcaa ctttttttcg gaggccggaa atgaagacta 10585 gtaagcgcgg aaagcggccg accgcgatgg ctcgctgccg tagtctggag aagaatcgcc 10645 agggttgcgt tgcggtgtgc cccggttcga ggccggccgg attccgcggc taacgagggc 10705 gtggctgccc cgtcgtttcc aagaccccct agccagccga cttctccagt tacggagcga 10765 gcccctcttt tgttttgttt gtttttgcca g atg cat ccc gta ctg cgg cag 10817 Met His Pro Val Leu Arg Gln 365 370 atg cgc ccc cac cac cct cca ccg caa caa cag ccc cct cca cag ccg 10865 Met Arg Pro His His Pro Pro Pro Gln Gln Gln Pro Pro Pro Gln Pro 375 380 385 gcg ctt ctg ccc ccg ccc cag cag cag cag caa ctt cca gcc acg acc 10913 Ala Leu Leu Pro Pro Pro Gln Gln Gln Gln Gln Leu Pro Ala Thr Thr 390 395 400 gcc gcg gcc gcc gtg agc ggg gct gga cag act tct cag tat gac ctg 10961 Ala Ala Ala Ala Val Ser Gly Ala Gly Gln Thr Ser Gln Tyr Asp Leu 405 410 415 gcc ttg gaa gag ggc gag ggg ctg gcg cgc ctg ggg gcg tcg tcg ccg 11009 Ala Leu Glu Glu Gly Glu Gly Leu Ala Arg Leu Gly Ala Ser Ser Pro 420 425 430 gag cgg cac ccg cgc gtg cag atg aaa agg gac gct cgc gag gcc tac 11057 Glu Arg His Pro Arg Val Gln Met Lys Arg Asp Ala Arg Glu Ala Tyr 435 440 445 450 gtg ccc aag cag aac ctg ttc aga gac agg agc ggc gag gag ccc gag 11105 Val Pro Lys Gln Asn Leu Phe Arg Asp Arg Ser Gly Glu Glu Pro Glu 455 460 465 gag atg cgc gcg gcc cgg ttc cac gcg ggg cgg gag ctg cgg cgc ggc 11153 Glu Met Arg Ala Ala Arg Phe His Ala Gly Arg Glu Leu Arg Arg Gly 470 475 480 ctg gac cga aag agg gtg ctg agg gac gag gat ttc gag gcg gac gag 11201 Leu Asp Arg Lys Arg Val Leu Arg Asp Glu Asp Phe Glu Ala Asp Glu 485 490 495 ctg acg ggg atc agc ccc gcg cgc gcg cac gtg gcc gcg gcc aac ctg 11249 Leu Thr Gly Ile Ser Pro Ala Arg Ala His Val Ala Ala Ala Asn Leu 500 505 510 gtc acg gcg tac gag cag acc gtg aag gag gag agc aac ttc caa aaa 11297 Val Thr Ala Tyr Glu Gln Thr Val Lys Glu Glu Ser Asn Phe Gln Lys 515 520 525 530 tcc ttc aac aac cac gtg cgc acc ctg atc gcg cgc gag gag gtg acc 11345 Ser Phe Asn Asn His Val Arg Thr Leu Ile Ala Arg Glu Glu Val Thr 535 540 545 ctg ggc ctg atg cac ctg tgg gac ctg ctg gag gcc atc gtg cag aac 11393 Leu Gly Leu Met His Leu Trp Asp Leu Leu Glu Ala Ile Val Gln Asn 550 555 560 ccc acc agc aag ccg ctg acg gcg cag ctg ttc ctg gtg gtg cag cat 11441 Pro Thr Ser Lys Pro Leu Thr Ala Gln Leu Phe Leu Val Val Gln His 565 570 575 agt cgg gac aac gag gcg ttc agg gag gcg ctg ctg aat atc acc gag 11489 Ser Arg Asp Asn Glu Ala Phe Arg Glu Ala Leu Leu Asn Ile Thr Glu 580 585 590 ccc gag ggc cgc tgg ctc ctg gac ctg gtg aac att ctg cag agc atc 11537 Pro Glu Gly Arg Trp Leu Leu Asp Leu Val Asn Ile Leu Gln Ser Ile 595 600 605 610 gtg gtg cag gag cgc ggg ctg ccg ctg tcc gag aag ctg gcg gcc atc 11585 Val Val Gln Glu Arg Gly Leu Pro Leu Ser Glu Lys Leu Ala Ala Ile 615 620 625 aac ttc tcg gtg ctg agt ctg ggc aag tac tac gct agg aag atc tac 11633 Asn Phe Ser Val Leu Ser Leu Gly Lys Tyr Tyr Ala Arg Lys Ile Tyr 630 635 640 aag acc ccg tac gtg ccc ata gac aag gag gtg aag atc gac ggg ttt 11681 Lys Thr Pro Tyr Val Pro Ile Asp Lys Glu Val Lys Ile Asp Gly Phe 645 650 655 tac atg cgc atg acc ctg aaa gtg ctg acc ctg agc gac gat ctg ggg 11729 Tyr Met Arg Met Thr Leu Lys Val Leu Thr Leu Ser Asp Asp Leu Gly 660 665 670 gtg tac cgc aac gac agg atg cac cgc gcg gtg agc gcc agc agg cgg 11777 Val Tyr Arg Asn Asp Arg Met His Arg Ala Val Ser Ala Ser Arg Arg 675 680 685 690 cgc gag ctg agc gac cag gag ctg atg cat agt ctg cag cgg gcc ctg 11825 Arg Glu Leu Ser Asp Gln Glu Leu Met His Ser Leu Gln Arg Ala Leu 695 700 705 acc ggg gcc ggg acc gag ggg gag agc tac ttt gac atg ggc gcg gac 11873 Thr Gly Ala Gly Thr Glu Gly Glu Ser Tyr Phe Asp Met Gly Ala Asp 710 715 720 ctg cac tgg cag ccc agc cgc cgg gcc ttg gag gcg gca ggc ggt ccc 11921 Leu His Trp Gln Pro Ser Arg Arg Ala Leu Glu Ala Ala Gly Gly Pro 725 730 735 ccc tac ata gaa gag gtg gac gat gag gtg gac gag gag ggc gag tac 11969 Pro Tyr Ile Glu Glu Val Asp Asp Glu Val Asp Glu Glu Gly Glu Tyr 740 745 750 ctg gaa gac tgatggcgcg accgtatttt tgctag atg caa caa cag cca cct 12022 Leu Glu Asp Met Gln Gln Gln Pro Pro 755 760 cct gat ccc gcg atg cgg gcg gcg ctg cag agc cag ccg tcc ggc att 12070 Pro Asp Pro Ala Met Arg Ala Ala Leu Gln Ser Gln Pro Ser Gly Ile 765 770 775 aac tcc tcg gac gat tgg acc cag gcc atg caa cgc atc atg gcg ctg 12118 Asn Ser Ser Asp Asp Trp Thr Gln Ala Met Gln Arg Ile Met Ala Leu 780 785 790 795 acg acc cgc aac ccc gaa gcc ttt aga cag cag ccc cag gcc aac cgg 12166 Thr Thr Arg Asn Pro Glu Ala Phe Arg Gln Gln Pro Gln Ala Asn Arg 800 805 810 ctc tcg gcc atc ctg gag gcc gtg gtg ccc tcg cgc tcc aac ccc acg 12214 Leu Ser Ala Ile Leu Glu Ala Val Val Pro Ser Arg Ser Asn Pro Thr 815 820 825 cac gag aag gtc ctg gcc atc gtg aac gcg ctg gtg gag aac aag gcc 12262 His Glu Lys Val Leu Ala Ile Val Asn Ala Leu Val Glu Asn Lys Ala 830 835 840 atc cgc ggc gac gag gcc ggc ctg gtg tac aac gcg ctg ctg gag cgc 12310 Ile Arg Gly Asp Glu Ala Gly Leu Val Tyr Asn Ala Leu Leu Glu Arg 845 850 855 gtg gcc cgc tac aac agc acc aac gtg cag acc aac ctg gac cgc atg 12358 Val Ala Arg Tyr Asn Ser Thr Asn Val Gln Thr Asn Leu Asp Arg Met 860 865 870 875 gtg acc gac gtg cgc gag gcc gtg gcc cag cgc gag cgg ttc cac cgc 12406 Val Thr Asp Val Arg Glu Ala Val Ala Gln Arg Glu Arg Phe His Arg 880 885 890 gag tcc aac ctg gga tcc atg gtg gcg ctg aac gcc ttc ctc agc acc 12454 Glu Ser Asn Leu Gly Ser Met Val Ala Leu Asn Ala Phe Leu Ser Thr 895 900 905 cag ccc gcc aac gtg ccc cgg ggc cag gag gac tac acc aac ttc atc 12502 Gln Pro Ala Asn Val Pro Arg Gly Gln Glu Asp Tyr Thr Asn Phe Ile 910 915 920 agc gcc ctg cgc ctg atg gtg acc gag gtg ccc cag agc gag gtg tac 12550 Ser Ala Leu Arg Leu Met Val Thr Glu Val Pro Gln Ser Glu Val Tyr 925 930 935 cag tcc ggg ccg gac tac ttc ttc cag acc agt cgc cag ggc ttg cag 12598 Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr Ser Arg Gln Gly Leu Gln 940 945 950 955 acc gtg aac ctg agc cag gcg ttc aag aac ttg cag ggc ctg tgg ggc 12646 Thr Val Asn Leu Ser Gln Ala Phe Lys Asn Leu Gln Gly Leu Trp Gly 960 965 970 gtg cag gcc ccg gtc ggg gac cgc gcg acg gtg tcg agc ctg ctg acg 12694 Val Gln Ala Pro Val Gly Asp Arg Ala Thr Val Ser Ser Leu Leu Thr 975 980 985 ccg aac tcg cgc ctg ctg ctg ctg ctg gtg gcc ccc ttc acg gac agc 12742 Pro Asn Ser Arg Leu Leu Leu Leu Leu Val Ala Pro Phe Thr Asp Ser 990 995 1000 ggc agc atc aac cgc aac tcg tac ctg ggc tac ctg att aac ctg 12787 Gly Ser Ile Asn Arg Asn Ser Tyr Leu Gly Tyr Leu Ile Asn Leu 1005 1010 1015 tac cgc gag gcc atc ggc cag gcg cac gtg gac gag cag acc tac 12832 Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp Glu Gln Thr Tyr 1020 1025 1030 cag gag atc acc cac gtg agc cgc gcc ctg ggc cag gac gac ccg 12877 Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly Gln Asp Asp Pro 1035 1040 1045 ggc aat ctg gaa gcc acc ctg aac ttt ttg ctg acc aac cgg tcg 12922 Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr Asn Arg Ser 1050 1055 1060 cag aag atc ccg ccc cag tac acg ctc agc gcc gag gag gag cgc 12967 Gln Lys Ile Pro Pro Gln Tyr Thr Leu Ser Ala Glu Glu Glu Arg 1065 1070 1075 atc ctg cga tac gtg cag cag agc gtg ggc ctg ttc ctg atg cag 13012 Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met Gln 1080 1085 1090 gag ggg gcc acc ccc agc gcc gcg ctc gac atg acc gcg cgc aac 13057 Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn 1095 1100 1105 atg gag ccc agc atg tac gcc agc aac cgc ccg ttc atc aat aaa 13102 Met Glu Pro Ser Met Tyr Ala Ser Asn Arg Pro Phe Ile Asn Lys 1110 1115 1120 ctg atg gac tac ttg cat cgg gcg gcc gcc atg aac tct gac tat 13147 Leu Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr 1125 1130 1135 ttc acc aac gcc atc ctg aat ccc cac tgg ctc ccg ccg ccg ggg 13192 Phe Thr Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly 1140 1145 1150 ttc tac acg ggc gag tac gac atg ccc gac ccc aat gac ggg ttc 13237 Phe Tyr Thr Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe 1155 1160 1165 ctg tgg gac gat gtg gac agc agc gtg ttc tcc ccc cga ccg ggt 13282 Leu Trp Asp Asp Val Asp Ser Ser Val Phe Ser Pro Arg Pro Gly 1170 1175 1180 gct aac gag cgc ccc ttg tgg aag aag gaa ggc agc gac cga cgc 13327 Ala Asn Glu Arg Pro Leu Trp Lys Lys Glu Gly Ser Asp Arg Arg 1185 1190 1195 ccg tcc tcg gcg ctg tcc ggc cgc gag ggt gct gcc gcg gcg gtg 13372 Pro Ser Ser Ala Leu Ser Gly Arg Glu Gly Ala Ala Ala Ala Val 1200 1205 1210 ccc gag gcc gcc agt cct ttc ccg agc ttg ccc ttc tcg ctg aac 13417 Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu Pro Phe Ser Leu Asn 1215 1220 1225 agt att cgc agc agc gag ctg ggc agg atc acg cgc ccg cgc ttg 13462 Ser Ile Arg Ser Ser Glu Leu Gly Arg Ile Thr Arg Pro Arg Leu 1230 1235 1240 ctg ggc gag gag gag tac ttg aat gac tcg ctg ttg aga ccc gag 13507 Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu Arg Pro Glu 1245 1250 1255 cgg gag aag aac ttc ccc aat aac ggg ata gag agc ctg gtg gac 13552 Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu Val Asp 1260 1265 1270 aag atg agc cgc tgg aag acg tat gcg cag gag cac agg gac gat 13597 Lys Met Ser Arg Trp Lys Thr Tyr Ala Gln Glu His Arg Asp Asp 1275 1280 1285 ccg tcg cag ggg gcc acg agc cgg ggc agc gcc gcc cgt aaa cgc 13642 Pro Ser Gln Gly Ala Thr Ser Arg Gly Ser Ala Ala Arg Lys Arg 1290 1295 1300 cgg tgg cac gac agg cag cgg gga ctg atg tgg gac gat gag gat 13687 Arg Trp His Asp Arg Gln Arg Gly Leu Met Trp Asp Asp Glu Asp 1305 1310 1315 tcc gcc gac gac agc agc gtg ttg gac ttg ggt ggg agt ggt aac 13732 Ser Ala Asp Asp Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Asn 1320 1325 1330 ccg ttc gct cac ctg cgc ccc cgc atc ggg cgc atg atg taagagaaac 13781 Pro Phe Ala His Leu Arg Pro Arg Ile Gly Arg Met Met 1335 1340 1345 cgaaaataaa tgatactcac caaggccatg gcgaccagcg tgcgttcgtt tcttctctgt 13841 tgttgtatct agt atg atg agg cgt gcg tac ccg gag ggt cct cct ccc 13890 Met Met Arg Arg Ala Tyr Pro Glu Gly Pro Pro Pro 1350 1355 tcg tac gag agc gtg atg cag cag gcg atg gcg gcg gcg gcg gcg 13935 Ser Tyr Glu Ser Val Met Gln Gln Ala Met Ala Ala Ala Ala Ala 1360 1365 1370 atg cag ccc ccg ctg gag gct cct tac gtg ccc ccg cgg tac ctg 13980 Met Gln Pro Pro Leu Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu 1375 1380 1385 gcg cct acg gag ggg cgg aac agc att cgt tac tcg gag ctg gca 14025 Ala Pro Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala 1390 1395 1400 ccc ttg tac gat acc acc cgg ttg tac ctg gtg gac aac aag tcg 14070 Pro Leu Tyr Asp Thr Thr Arg Leu Tyr Leu Val Asp Asn Lys Ser 1405 1410 1415 gcg gac atc gcc tcg ctg aac tac cag aac gac cac agc aac ttc 14115 Ala Asp Ile Ala Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe 1420 1425 1430 ctg acc acc gtg gtg cag aac aat gac ttc acc ccc acg gag gcc 14160 Leu Thr Thr Val Val Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala 1435 1440 1445 agc acc cag acc atc aac ttt gac gag cgc tcg cgg tgg ggc ggt 14205 Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly 1450 1455 1460 cag ctg aaa acc atc atg cac acc aac atg ccc aac gtg aac gag 14250 Gln Leu Lys Thr Ile Met His Thr Asn Met Pro Asn Val Asn Glu 1465 1470 1475 ttc atg tac agc aac aag ttc aag gcg cgg gtg atg gtc tcc cgc 14295 Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser Arg 1480 1485 1490 aag acc ccc aac ggg gtg aca gtg aca gat ggt agt cag gat atc 14340 Lys Thr Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln Asp Ile 1495 1500 1505 ttg gag tat gaa tgg gtg gag ttt gag ctg ccc gaa ggc aac ttc 14385 Leu Glu Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn Phe 1510 1515 1520 tcg gtg acc atg acc atc gac ctg atg aac aac gcc atc atc gac 14430 Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp 1525 1530 1535 aat tac ttg gcg gtg ggg cgg cag aac ggg gtc ctg gag agc gat 14475 Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp 1540 1545 1550 atc ggc gtg aag ttc gac act agg aac ttc agg ctg ggc tgg gac 14520 Ile Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp 1555 1560 1565 ccc gtg acc gag ctg gtc atg ccc ggg gtg tac acc aac gag gcc 14565 Pro Val Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala 1570 1575 1580 ttc cac ccc gat att gtc ttg ctg ccc ggc tgc ggg gtg gac ttc 14610 Phe His Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe 1585 1590 1595 acc gag agc cgc ctc agc aac ctg ctg ggc att cgc aag agg cag 14655 Thr Glu Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln 1600 1605 1610 ccc ttc cag gag ggc ttc cag atc atg tac gag gat ctg gag ggg 14700 Pro Phe Gln Glu Gly Phe Gln Ile Met Tyr Glu Asp Leu Glu Gly 1615 1620 1625 ggc aac atc ccc gcg ctc ctg gat gtc gac gcc tat gag aaa agc 14745 Gly Asn Ile Pro Ala Leu Leu Asp Val Asp Ala Tyr Glu Lys Ser 1630 1635 1640 aag gag gag agc gcc gcc gcg gcg act gca gct gta gcc acc gcc 14790 Lys Glu Glu Ser Ala Ala Ala Ala Thr Ala Ala Val Ala Thr Ala 1645 1650 1655 tct acc gag gtc agg ggc gat aat ttt gcc agc cct gca gca gtg 14835 Ser Thr Glu Val Arg Gly Asp Asn Phe Ala Ser Pro Ala Ala Val 1660 1665 1670 gca gcg gcc gag gcg gct gaa acc gaa agt aag ata gtc att cag 14880 Ala Ala Ala Glu Ala Ala Glu Thr Glu Ser Lys Ile Val Ile Gln 1675 1680 1685 ccg gtg gag aag gat agc aag gac agg agc tac aac gtg ctg ccg 14925 Pro Val Glu Lys Asp Ser Lys Asp Arg Ser Tyr Asn Val Leu Pro 1690 1695 1700 gac aag ata aac acc gcc tac cgc agc tgg tac ctg gcc tac aac 14970 Asp Lys Ile Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn 1705 1710 1715 tat ggc gac ccc gag aag ggc gtg cgc tcc tgg acg ctg ctc acc 15015 Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu Thr 1720 1725 1730 acc tcg gac gtc acc tgc ggc gtg gag caa gtc tac tgg tcg ctg 15060 Thr Ser Asp Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser Leu 1735 1740 1745 ccc gac atg atg caa gac ccg gtc acc ttc cgc tcc acg cgt caa 15105 Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln 1750 1755 1760 gtt agc aac tac ccg gtg gtg ggc gcc gag ctc ctg ccc gtc tac 15150 Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val Tyr 1765 1770 1775 tcc aag agc ttc ttc aac gag cag gcc gtc tac tcg cag cag ctg 15195 Ser Lys Ser Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu 1780 1785 1790 cgc gcc ttc acc tcg ctc acg cac gtc ttc aac cgc ttc ccc gag 15240 Arg Ala Phe Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu 1795 1800 1805 aac cag atc ctc gtc cgc ccg ccc gcg ccc acc att acc acc gtc 15285 Asn Gln Ile Leu Val Arg Pro Pro Ala Pro Thr Ile Thr Thr Val 1810 1815 1820 agt gaa aac gtt cct gct ctc aca gat cac ggg acc ctg ccg ctg 15330 Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu 1825 1830 1835 cgc agc agt atc cgg gga gtc cag cgc gtg acc gtt act gac gcc 15375 Arg Ser Ser Ile Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala 1840 1845 1850 aga cgc cgc acc tgc ccc tac gtc tac aag gcc ctg ggc ata gtc 15420 Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val 1855 1860 1865 gcg ccg cgc gtc ctc tcg agc cgc acc ttc taaaaa atg tcc att ctc 15468 Ala Pro Arg Val Leu Ser Ser Arg Thr Phe Met Ser Ile Leu 1870 1875 1880 atc tcg ccc agt aat aac acc ggt tgg ggc ctg cgc gcg ccc agc 15513 Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg Ala Pro Ser 1885 1890 1895 aag atg tac gga ggc gct cgc caa cgc tcc acg caa cac ccc gtg 15558 Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His Pro Val 1900 1905 1910 cgc gtg cgc ggg cac ttc cgc gct ccc tgg ggc gcc ctc aag ggc 15603 Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys Gly 1915 1920 1925 cgc gtg cgg tcg cgc acc acc gtc gac gac gtg atc gac cag gtg 15648 Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 1930 1935 1940 gtg gcc gac gcg cgc aac tac acc ccc gcc gcc gcg ccc gtc tcc 15693 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Val Ser 1945 1950 1955 acc gtg gac gcc gtc atc gac agc gtg gtg gcc gac gcg cgc cgg 15738 Thr Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg 1960 1965 1970 tac gcc cgc gcc aag agc cgg cgg cgg cgc atc gcc cgg cgg cac 15783 Tyr Ala Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His 1975 1980 1985 cgg agc acc ccc gcc atg cgc gcg gcg cga gcc ttg ctg cgc agg 15828 Arg Ser Thr Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg 1990 1995 2000 gcc agg cgc acg gga cgc agg gcc atg ctc agg gcg gcc aga cgc 15873 Ala Arg Arg Thr Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg 2005 2010 2015 gcg gcc tca ggc gcc agc gcc ggc agg acc cgg aga cgc gcg gcc 15918 Ala Ala Ser Gly Ala Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala 2020 2025 2030 acg gcg gcg gca gcg gcc atc gcc agc atg tcc cgc ccg cgg cga 15963 Thr Ala Ala Ala Ala Ala Ile Ala Ser Met Ser Arg Pro Arg Arg 2035 2040 2045 ggg aac gtg tac tgg gtg cgc gac gcc gcc acc ggt gtg cgc gtg 16008 Gly Asn Val Tyr Trp Val Arg Asp Ala Ala Thr Gly Val Arg Val 2050 2055 2060 ccc gtg cgc acc cgc ccc cct cgc act tgaagatgtt cacttcgcga 16055 Pro Val Arg Thr Arg Pro Pro Arg Thr 2065 2070 tgttgatgtg tcccagcggc gagg atg tcc aag cgc aaa ttc aag gaa gag 16106 Met Ser Lys Arg Lys Phe Lys Glu Glu 2075 2080 atg ctc cag gtc atc gcg cct gag atc tac ggc ccc gcg gtg gtg 16151 Met Leu Gln Val Ile Ala Pro Glu Ile Tyr Gly Pro Ala Val Val 2085 2090 2095 aag gag gaa aga aag ccc cgc aaa atc aag cgg gtc aaa aag gac 16196 Lys Glu Glu Arg Lys Pro Arg Lys Ile Lys Arg Val Lys Lys Asp 2100 2105 2110 aaa aag gaa gaa gaa agt gat gtg gac gga ctg gtg gag ttt gtg 16241 Lys Lys Glu Glu Glu Ser Asp Val Asp Gly Leu Val Glu Phe Val 2115 2120 2125 cgc gag ttc gcc ccc cgg cgg cgc gtg cag tgg cgc ggg cgg aag 16286 Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp Arg Gly Arg Lys 2130 2135 2140 gtg cgc ccg gtg ctg aga cca ggc act acg gtg gtc ttc acg ccc 16331 Val Arg Pro Val Leu Arg Pro Gly Thr Thr Val Val Phe Thr Pro 2145 2150 2155 ggc gag cgc tcc ggc acc gct tcc aag cgc tcc tac gac gag gtg 16376 Gly Glu Arg Ser Gly Thr Ala Ser Lys Arg Ser Tyr Asp Glu Val 2160 2165 2170 tac ggg gac gag gac atc ctc gag cag gcg gcc gag cgc ctg ggc 16421 Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu Gly 2175 2180 2185 gag ttt gct tac ggc aag cgc agc cgc tcc gcg ccg aag gaa gag 16466 Glu Phe Ala Tyr Gly Lys Arg Ser Arg Ser Ala Pro Lys Glu Glu 2190 2195 2200 gcg gtg tcc atc ccg ctg gac cac ggc aac ccc acg ccg agc ctc 16511 Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu 2205 2210 2215 aag ccc gtg acc ctg cag cag gtg ctg ccg acc gcg gcg ccg cgc 16556 Lys Pro Val Thr Leu Gln Gln Val Leu Pro Thr Ala Ala Pro Arg 2220 2225 2230 cgg ggg ttc aag cgc gag ggc gag gat ctg tac ccc acc atg cag 16601 Arg Gly Phe Lys Arg Glu Gly Glu Asp Leu Tyr Pro Thr Met Gln 2235 2240 2245 ctg atg gtg ccc aag cgc cag aag ctg gaa gac gtg ctg gag acc 16646 Leu Met Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu Thr 2250 2255 2260 atg aag gtg gac ccg gac gtg cag ccc gag gtc aag gtg cgg ccc 16691 Met Lys Val Asp Pro Asp Val Gln Pro Glu Val Lys Val Arg Pro 2265 2270 2275 atc aag cag gtg gcc ccg ggc ctg ggc gtg cag acc gtg gac atc 16736 Ile Lys Gln Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile 2280 2285 2290 aag atc ccc acg gag ccc atg gaa acg cag acc gag ccc gtg aaa 16781 Lys Ile Pro Thr Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys 2295 2300 2305 ccc agc acc agc acc atg gag gtg cag acg gat cct tgg atg cca 16826 Pro Ser Thr Ser Thr Met Glu Val Gln Thr Asp Pro Trp Met Pro 2310 2315 2320 tcg gct act agc cga aga ccc cgg cgc aag tac ggc gcg gcc agc 16871 Ser Ala Thr Ser Arg Arg Pro Arg Arg Lys Tyr Gly Ala Ala Ser 2325 2330 2335 ctg ctg atg ccc aac tac gcg ctg cat cct tcc atc atc ccc acg 16916 Leu Leu Met Pro Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr 2340 2345 2350 ccg ggc tac cgc ggc acg cgc ttc tac cgc ggt cat aca agc cgc 16961 Pro Gly Tyr Arg Gly Thr Arg Phe Tyr Arg Gly His Thr Ser Arg 2355 2360 2365 cgc cgc aag acc acc acc cgc cgc cgc cgt cgc cgc aca acc gct 17006 Arg Arg Lys Thr Thr Thr Arg Arg Arg Arg Arg Arg Thr Thr Ala 2370 2375 2380 gct gca tct acc cct gcc gcc ctg gtg cgg aga gtg tac cgc cgc 17051 Ala Ala Ser Thr Pro Ala Ala Leu Val Arg Arg Val Tyr Arg Arg 2385 2390 2395 ggc cgc gcg cct ctg acc ctg ccg cgc gcg cgc tac cac ccg agc 17096 Gly Arg Ala Pro Leu Thr Leu Pro Arg Ala Arg Tyr His Pro Ser 2400 2405 2410 att gcc att taaactttcg cctgctttgc agatca atg gcc ctc aca tgc cgc 17149 Ile Ala Ile Met Ala Leu Thr Cys Arg 2415 ctc cgc gtt ccc att acg ggc tac cga gga aga aaa ccg cgc cgt 17194 Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly Arg Lys Pro Arg Arg 2420 2425 2430 aga agg ctg gcg ggg aac ggg atg cgt cgc cac cac cac cgg cgg 17239 Arg Arg Leu Ala Gly Asn Gly Met Arg Arg His His His Arg Arg 2435 2440 2445 cgg cgc gcc atc agc aag cgg ttg ggg gga ggc ttc ctg ccc gcg 17284 Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe Leu Pro Ala 2450 2455 2460 ctg atc ccc atc atc gcc gcg gcg atc ggg gcg atc ccc ggc att 17329 Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro Gly Ile 2465 2470 2475 gct tcc gtg gcg gtg cag gcc tct cag cgc cac tgagacacac 17372 Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 2480 2485 2490 ttggaaacat cttgtaataa acca atg gac tct gac gct cct ggt cct gtg 17423 Met Asp Ser Asp Ala Pro Gly Pro Val 2495 atg tgt ttt cgt aga cag atg gaa gac atc aat ttt tcg tcc ctg 17468 Met Cys Phe Arg Arg Gln Met Glu Asp Ile Asn Phe Ser Ser Leu 2500 2505 2510 gct ccg cga cac ggc acg cgg ccg ttc atg ggc acc tgg agc gac 17513 Ala Pro Arg His Gly Thr Arg Pro Phe Met Gly Thr Trp Ser Asp 2515 2520 2525 atc ggc acc agc caa ctg aac ggg ggc gcc ttc aat tgg agc agt 17558 Ile Gly Thr Ser Gln Leu Asn Gly Gly Ala Phe Asn Trp Ser Ser 2530 2535 2540 ctc tgg agc ggg ctt aag aat ttc ggg tcc acg ctt aaa acc tat 17603 Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser Thr Leu Lys Thr Tyr 2545 2550 2555 ggc agc aag gcg tgg aac agc acc aca ggg cag gcg ctg agg gat 17648 Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly Gln Ala Leu Arg Asp 2560 2565 2570 aag ctg aaa gag cag aac ttc cag cag aag gtg gtc gat ggc ctg 17693 Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val Val Asp Gly Leu 2575 2580 2585 gcc tcg ggc atc aac ggg gtg gtg gac ctg gcc aac cag gcc gtg 17738 Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn Gln Ala Val 2590 2595 2600 cag cgg cag atc aac agc cgc ctg gac ccg gtg ccg ccc gcc ggc 17783 Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro Ala Gly 2605 2610 2615 tcc gtg gag atg ccg cag gtg gag gag gag ctg cct ccc ctg gac 17828 Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu Asp 2620 2625 2630 aag cgg ggc gag aag cga ccc cgc ccc gac gcg gag gag acg ctg 17873 Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu 2635 2640 2645 ctg acg cac acg gac gag ccg ccc ccg tac gag gag gcg gtg aaa 17918 Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys 2650 2655 2660 ctg ggc ctg ccc acc acg cgg ccc atc gcg cct ctg gcc acc ggg 17963 Leu Gly Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly 2665 2670 2675 gtg ctg aaa ccc gaa agt agt aag ccc gcg acc ctg gac ttg cct 18008 Val Leu Lys Pro Glu Ser Ser Lys Pro Ala Thr Leu Asp Leu Pro 2680 2685 2690 cct ccc cag cct tcc cgc ccc tcc aca gtg gct aag cct ctg ccg 18053 Pro Pro Gln Pro Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro 2695 2700 2705 ccg gtg gcc gtg gcc cgc gcg cga ccc ggg ggc acc gcc cgc cct 18098 Pro Val Ala Val Ala Arg Ala Arg Pro Gly Gly Thr Ala Arg Pro 2710 2715 2720 cat gcg aac tgg cag agc act ctg aac agc atc gtg ggt ctg gga 18143 His Ala Asn Trp Gln Ser Thr Leu Asn Ser Ile Val Gly Leu Gly 2725 2730 2735 gtg cag agt gtg aag cgc cgc cgc tgc tat taaacctacc gtagcgctta 18193 Val Gln Ser Val Lys Arg Arg Arg Cys Tyr 2740 2745 acttgcttgt ctgtgtgtgt atgtattatg tcgccgccgc tgtcgccaga aggaggagtg 18253 aagaggcgcg tcgccgagtt gcaag atg gcc acc cca tcg atg ctg ccc cag 18305 Met Ala Thr Pro Ser Met Leu Pro Gln 2750 2755 tgg gcg tac atg cac atc gcc gga cag gac gct tcg gag tac ctg 18350 Trp Ala Tyr Met His Ile Ala Gly Gln Asp Ala Ser Glu Tyr Leu 2760 2765 2770 agt ccg ggt ctg gtg cag ttc gcc cgc gcc aca gac acc tac ttc 18395 Ser Pro Gly Leu Val Gln Phe Ala Arg Ala Thr Asp Thr Tyr Phe 2775 2780 2785 agt ctg ggg aac aag ttt agg aac ccc acg gtg gcg ccc acg cac 18440 Ser Leu Gly Asn Lys Phe Arg Asn Pro Thr Val Ala Pro Thr His 2790 2795 2800 gat gtg acc acc gac cgc agc cag cgg ctg acg ctg cgc ttc gtg 18485 Asp Val Thr Thr Asp Arg Ser Gln Arg Leu Thr Leu Arg Phe Val 2805 2810 2815 ccc gtg gac cgc gag gac aac acc tac tcg tac aaa gtg cgc tac 18530 Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr Lys Val Arg Tyr 2820 2825 2830 acg ctg gcc gtg ggc gac aac cgc gtg ctg gac atg gcc agc acc 18575 Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met Ala Ser Thr 2835 2840 2845 tac ttt gac atc cgc ggc gtg ctg gac cgg ggc cct agc ttc aaa 18620 Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser Phe Lys 2850 2855 2860 ccc tac tcc ggc acc gcc tac aat gct ctg gcc ccc aag gga gca 18665 Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly Ala 2865 2870 2875 ccc aac act tgc cag tgg aca tac aca gat aag caa acc gaa aaa 18710 Pro Asn Thr Cys Gln Trp Thr Tyr Thr Asp Lys Gln Thr Glu Lys 2880 2885 2890 aca gcc acg tat ggg aat gcg cct gta caa ggc att gcc atc aca 18755 Thr Ala Thr Tyr Gly Asn Ala Pro Val Gln Gly Ile Ala Ile Thr 2895 2900 2905 aaa gat ggt att caa ctt gga act gac agt gat gga aat cct gta 18800 Lys Asp Gly Ile Gln Leu Gly Thr Asp Ser Asp Gly Asn Pro Val 2910 2915 2920 tat gct caa aag aca ttt gaa ccc gaa cct caa gtg ggt gat gca 18845 Tyr Ala Gln Lys Thr Phe Glu Pro Glu Pro Gln Val Gly Asp Ala 2925 2930 2935 gaa tgg cat gac act aca ggt aca gat gaa aag tat gga ggc agg 18890 Glu Trp His Asp Thr Thr Gly Thr Asp Glu Lys Tyr Gly Gly Arg 2940 2945 2950 gca ctt aag cct gac acc aaa atg aag cct tgc tat ggt tct ttt 18935 Ala Leu Lys Pro Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe 2955 2960 2965 gcc aaa ccc act aac aaa gaa ggt gga cag gca aag aac aga aca 18980 Ala Lys Pro Thr Asn Lys Glu Gly Gly Gln Ala Lys Asn Arg Thr 2970 2975 2980 aaa act gat gga act ggc gaa gag cct gat att gat atg gca ttt 19025 Lys Thr Asp Gly Thr Gly Glu Glu Pro Asp Ile Asp Met Ala Phe 2985 2990 2995 ttt gac ggc aga aat gca act aca gct ggt ttg gct cca gaa att 19070 Phe Asp Gly Arg Asn Ala Thr Thr Ala Gly Leu Ala Pro Glu Ile 3000 3005 3010 gtt ttg tat act gag aat gtg gat ctg gag act cca gat acc cat 19115 Val Leu Tyr Thr Glu Asn Val Asp Leu Glu Thr Pro Asp Thr His 3015 3020 3025 att gta tac aaa gca ggc aca gat gac agc agc tct tcg att aat 19160 Ile Val Tyr Lys Ala Gly Thr Asp Asp Ser Ser Ser Ser Ile Asn 3030 3035 3040 ttg ggg cag caa tcc atg ccc aac aga ccc aac tac att ggg ttc 19205 Leu Gly Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe 3045 3050 3055 aga gac aac ttt atc ggg ctc atg tac tac aac agc act ggc aat 19250 Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn 3060 3065 3070 atg ggg gtg ctg gcc ggt cag gct tct cag ctg aat gct gtg gtt 19295 Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val 3075 3080 3085 gac ttg caa gac aga aac acc gaa ctg tcc tac cag ctc ttg ctt 19340 Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu 3090 3095 3100 gac tct ctg ggc gac aga acc ctg tat ttc agt atg tgg aat cag 19385 Asp Ser Leu Gly Asp Arg Thr Leu Tyr Phe Ser Met Trp Asn Gln 3105 3110 3115 gcg gtg gac agc tat gat cct gat gtg cgc att att gaa aac cat 19430 Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His 3120 3125 3130 ggt gtg gaa gat gaa ctt ccc aac tat tgc ttc cct ctg gat gct 19475 Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asp Ala 3135 3140 3145 gtt ggt agg aca gat act tat cag gga att aag ccc aat gga ggc 19520 Val Gly Arg Thr Asp Thr Tyr Gln Gly Ile Lys Pro Asn Gly Gly 3150 3155 3160 gat cca gcc aca tgg gcc aaa gat gac agc gcc aat gat gct aat 19565 Asp Pro Ala Thr Trp Ala Lys Asp Asp Ser Ala Asn Asp Ala Asn 3165 3170 3175 gaa atg ggc aag ggc aat cca ttc gcc atg gaa atc aac atc caa 19610 Glu Met Gly Lys Gly Asn Pro Phe Ala Met Glu Ile Asn Ile Gln 3180 3185 3190 gcc aac ctg tgg agg aac ttc ctc tac gcc aac gtg gcc ctg tac 19655 Ala Asn Leu Trp Arg Asn Phe Leu Tyr Ala Asn Val Ala Leu Tyr 3195 3200 3205 cta ccc gat tct tac aag tac acg ccg gcc aac gtc acc ctg ccc 19700 Leu Pro Asp Ser Tyr Lys Tyr Thr Pro Ala Asn Val Thr Leu Pro 3210 3215 3220 acc aac acc aac acc tac gat tat atg aac ggc cgg gtg gtg gcg 19745 Thr Asn Thr Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val Val Ala 3225 3230 3235 cct tcg ctg gtg gac tcc tac atc aac atc ggg gcg cgc tgg tcg 19790 Pro Ser Leu Val Asp Ser Tyr Ile Asn Ile Gly Ala Arg Trp Ser 3240 3245 3250 ctg gac ccc atg gac aac gtc aat ccc ttc aac cac cac cgc aac 19835 Leu Asp Pro Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn 3255 3260 3265 gcg ggc ttg cgc tac cgc tcc atg ctc ctg ggc aac ggg cgc tac 19880 Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr 3270 3275 3280 gtg ccc ttc cac atc cag gtg ccc cag aaa ttt ttc gcc atc aag 19925 Val Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys 3285 3290 3295 agc ctc ctg ctc ctg ccc ggg tcc tac acc tac gag tgg aac ttc 19970 Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe 3300 3305 3310 cgc aag gac gtc aac atg atc ctg cag agc tcc ctc ggc aac gac 20015 Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp 3315 3320 3325 ctg cgc acg gac ggg gcc tcc atc tcc ttc acc agc atc aac ctc 20060 Leu Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu 3330 3335 3340 tac gcc acc ttc ttc ccc atg gcg cac aac acg gcc tcc acg ctc 20105 Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu 3345 3350 3355 gag gcc atg ctg cgc aac gac acc aac gac cag tcc ttc aac gac 20150 Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp 3360 3365 3370 tac ctc tcg gcg gcc aac atg ctc tac ccc atc ccg gcc aac gcc 20195 Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala 3375 3380 3385 acc aac gtg ccc atc tcc atc ccc tcg cgc aac tgg gcc gcc ttc 20240 Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe 3390 3395 3400 cgc ggc tgg tcc ttc acg cgc ctc aag acc aag gag acg ccc tcg 20285 Arg Gly Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser 3405 3410 3415 ctg ggc tcc ggg ttc gac ccc tac ttc gtc tac tcg ggc tcc atc 20330 Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile 3420 3425 3430 ccc tac ctc gac ggc acc ttc tac ctc aac cac acc ttc aag aag 20375 Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys 3435 3440 3445 gtc tcc atc acc ttc gac tcc tcc gtc agc tgg ccc ggc aac gac 20420 Val Ser Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp 3450 3455 3460 cgg ctc ctg acg ccc aac gag ttc gaa atc aag cgc acc gtc gac 20465 Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp 3465 3470 3475 ggc gag ggc tac aac gtg gcc cag tgc aac atg acc aag gac tgg 20510 Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp 3480 3485 3490 ttc ctg gtc cag atg ctg gcc cac tac aac atc ggc tac cag ggc 20555 Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly 3495 3500 3505 ttc tac gtg ccc gag ggc tac aag gac cgc atg tac tcc ttc ttc 20600 Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe 3510 3515 3520 cgc aac ttc cag ccc atg agc cgc cag gtg gtg gac gag gtc aac 20645 Arg Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Val Asn 3525 3530 3535 tac aag gac tac cag gcc gtc acc ctg gcc tac cag cac aac aac 20690 Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn Asn 3540 3545 3550 tcg ggc ttc gtc ggc tac ctc gcg ccc acc atg cgc cag ggc cag 20735 Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln 3555 3560 3565 ccc tac ccc gcc aac tac ccg tac ccg ctc atc ggc aag agc gcc 20780 Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala 3570 3575 3580 gtc acc agc gtc acc cag aaa aag ttc ctc tgc gac agg gtc atg 20825 Val Thr Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met 3585 3590 3595 tgg cgc atc ccc ttc tcc agc aac ttc atg tcc atg ggc gcg ctc 20870 Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu 3600 3605 3610 acc gac ctc ggc cag aac atg ctc tat gcc aac tcc gcc cac gcg 20915 Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala 3615 3620 3625 cta gac atg aat ttc gaa gtc gac ccc atg gat gag tcc acc ctt 20960 Leu Asp Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu 3630 3635 3640 ctc tat gtt gtc ttc gaa gtc ttc gac gtc gtc cga gtg cac cag 21005 Leu Tyr Val Val Phe Glu Val Phe Asp Val Val Arg Val His Gln 3645 3650 3655 ccc cac cgc ggc gtc atc gag gcc gtc tac ctg cgc acc ccc ttc 21050 Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe 3660 3665 3670 tcg gcc ggt aac gcc acc acc taaattgcta cttgc atg atg gct gag 21098 Ser Ala Gly Asn Ala Thr Thr Met Met Ala Glu 3675 3680 gcc gcg ggc tcc ggc gag cag gag ctc agg gcc atc atc cgc gac 21143 Ala Ala Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile Arg Asp 3685 3690 3695 ctg ggc tgc ggg ccc tac ttc ctg ggc acc ttc gat aag cgc ttc 21188 Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg Phe 3700 3705 3710 ccg gga ttc atg gcc ccg cac aag ctg gcc tgc gcc atc gtc aac 21233 Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn 3715 3720 3725 acg gcc ggt cgc gag acc ggg ggc gag cac tgg ctg gcc ttc gcc 21278 Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala 3730 3735 3740 tgg aac ccg cgc tcg aac acc tgc tac ctc ttc gac ccc ttc ggg 21323 Trp Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly 3745 3750 3755 ttc tcg gac gag cgc ctc aag cag atc tac cag ttc gag tac gag 21368 Phe Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu 3760 3765 3770 ggc ctg ctg cgc cgc agc gcc ctg gcc acc gag gac cgc tgc gtc 21413 Gly Leu Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val 3775 3780 3785 acc ctg gaa aag tcc acc cag acc gtg cag ggt ccg cgc tcg gcc 21458 Thr Leu Glu Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala 3790 3795 3800 gcc tgc ggg ctc ttc tgc tgc atg ttc ctg cac gcc ttc gtg cac 21503 Ala Cys Gly Leu Phe Cys Cys Met Phe Leu His Ala Phe Val His 3805 3810 3815 tgg ccc gac cgc ccc atg gac aag aac ccc acc atg aac ttg ctg 21548 Trp Pro Asp Arg Pro Met Asp Lys Asn Pro Thr Met Asn Leu Leu 3820 3825 3830 acg ggg gtg ccc aac ggc atg ctc cag tcg ccc cag gtg gaa ccc 21593 Thr Gly Val Pro Asn Gly Met Leu Gln Ser Pro Gln Val Glu Pro 3835 3840 3845 acc ctg cgc cgc aac cag gag gcg ctc tac cgc ttc ctc aac tcc 21638 Thr Leu Arg Arg Asn Gln Glu Ala Leu Tyr Arg Phe Leu Asn Ser 3850 3855 3860 cac tcc gcc tac ttt cgc tcc cac cgc gcg cgc atc gag aag gcc 21683 His Ser Ala Tyr Phe Arg Ser His Arg Ala Arg Ile Glu Lys Ala 3865 3870 3875 acc gcc ttc gat cgc atg aac aat caa gac atg taaaccgtgt 21726 Thr Ala Phe Asp Arg Met Asn Asn Gln Asp Met 3880 3885 3890 gtgtatgttt aaaatatctt ttaataaaca gcactttcat gttacacatg catctgagat 21786 gattattta gaa atc gaa agg gtt ctg ccg ggt ctc ggc atg gcc cgc 21834 Glu Ile Glu Arg Val Leu Pro Gly Leu Gly Met Ala Arg 3895 3900 ggg cag gga cac gtt gcg gaa ctg gta ctt ggc cag cca ctt gaa 21879 Gly Gln Gly His Val Ala Glu Leu Val Leu Gly Gln Pro Leu Glu 3905 3910 3915 ctc ggg gat cag cag ttt cgg cag cgg ggt gtc ggg gaa gga gtc 21924 Leu Gly Asp Gln Gln Phe Arg Gln Arg Gly Val Gly Glu Gly Val 3920 3925 3930 ggt cca cag ctt ccg cgt cag ttg cag ggc gcc cag cag gtc ggg 21969 Gly Pro Gln Leu Pro Arg Gln Leu Gln Gly Ala Gln Gln Val Gly 3935 3940 3945 cgc gga gat ctt gaa atc gca gtt ggg acc cgc gtt ctg cgc gcg 22014 Arg Gly Asp Leu Glu Ile Ala Val Gly Thr Arg Val Leu Arg Ala 3950 3955 3960 aga gtt gcg gta cac ggg gtt gca gca ctg gaa cac cat cag ggc 22059 Arg Val Ala Val His Gly Val Ala Ala Leu Glu His His Gln Gly 3965 3970 3975 cgg gtg ctt cac gct cgc cag cac cgt cgc gtc ggt gat gct ctc 22104 Arg Val Leu His Ala Arg Gln His Arg Arg Val Gly Asp Ala Leu 3980 3985 3990 cac gtc gag gtc ctc ggc gtt ggc cat ccc gaa ggg ggt cat ctt 22149 His Val Glu Val Leu Gly Val Gly His Pro Glu Gly Gly His Leu 3995 4000 4005 gca ggt ctg cct tcc cat agt ggg cac gca ccc ggg ctt gtg gtt 22194 Ala Gly Leu Pro Ser His Ser Gly His Ala Pro Gly Leu Val Val 4010 4015 4020 gca atc gca gtg cag ggg gat cag cat cat ctg ggc ctg gtc ggc 22239 Ala Ile Ala Val Gln Gly Asp Gln His His Leu Gly Leu Val Gly 4025 4030 4035 gtt cat ccc cgg gta cat ggc ctt cat gaa agc ctc caa ttg cct 22284 Val His Pro Arg Val His Gly Leu His Glu Ser Leu Gln Leu Pro 4040 4045 4050 gaa agc ctg ctg ggc ctt ggc tcc ctc ggt gaa gaa gac ccc gca 22329 Glu Ser Leu Leu Gly Leu Gly Ser Leu Gly Glu Glu Asp Pro Ala 4055 4060 4065 gga ctt gct aga gaa ctg gtt ggt agc gca ccc ggc gtc gtg cac 22374 Gly Leu Ala Arg Glu Leu Val Gly Ser Ala Pro Gly Val Val His 4070 4075 4080 gca gca gcg cgc gtc gtt gtt ggc cag ctg cac cac gct gcg ccc 22419 Ala Ala Ala Arg Val Val Val Gly Gln Leu His His Ala Ala Pro 4085 4090 4095 cca gcg gtt ctg ggt gat ctt ggc ccg gtc ggg gtt ctc ctt cag 22464 Pro Ala Val Leu Gly Asp Leu Gly Pro Val Gly Val Leu Leu Gln 4100 4105 4110 cgc gcg ctg ccc gtt ctc gct cgc cac atc cat ctc gat cat gtg 22509 Arg Ala Leu Pro Val Leu Ala Arg His Ile His Leu Asp His Val 4115 4120 4125 ctc ctt ctg gat cat ggt ggt ccc gtg cag gca ccg cag ctt gcc 22554 Leu Leu Leu Asp His Gly Gly Pro Val Gln Ala Pro Gln Leu Ala 4130 4135 4140 ctc ggt ctc ggt gca ccc gtg cag cca cag cgc gca ccc ggt gca 22599 Leu Gly Leu Gly Ala Pro Val Gln Pro Gln Arg Ala Pro Gly Ala 4145 4150 4155 ctc cca gtt ctt gtg ggc gat ctg gga atg cgc gtg cac gaa ccc 22644 Leu Pro Val Leu Val Gly Asp Leu Gly Met Arg Val His Glu Pro 4160 4165 4170 ctg cag gaa gcg gcc cat cat ggt ggt cag ggt ctt gtt gct agt 22689 Leu Gln Glu Ala Ala His His Gly Gly Gln Gly Leu Val Ala Ser 4175 4180 4185 gaa ggt cag cgg gat gcc gcg gtg ctc ctc gtt gat gta cag gtg 22734 Glu Gly Gln Arg Asp Ala Ala Val Leu Leu Val Asp Val Gln Val 4190 4195 4200 gca gat gcg gcg gta cac ctc gcc ctg ctc ggg cat cag ctg gaa 22779 Ala Asp Ala Ala Val His Leu Ala Leu Leu Gly His Gln Leu Glu 4205 4210 4215 gtt ggc ttt cag gtc ggt ctc cac gcg gta gcg gtc cat cag tat 22824 Val Gly Phe Gln Val Gly Leu His Ala Val Ala Val His Gln Tyr 4220 4225 4230 agt cat gat ttc cat acc ctt ctc cca ggc cga gac gat ggg cag 22869 Ser His Asp Phe His Thr Leu Leu Pro Gly Arg Asp Asp Gly Gln 4235 4240 4245 gct cat agg gtt ctt cac cat cat ctt agc act agc agc cgc ggc 22914 Ala His Arg Val Leu His His His Leu Ser Thr Ser Ser Arg Gly 4250 4255 4260 cag ggg gtc gct ctc atc cag ggt ctc aaa gct ccg ctt gcc gtc 22959 Gln Gly Val Ala Leu Ile Gln Gly Leu Lys Ala Pro Leu Ala Val 4265 4270 4275 ctt ctc ggt gat ccg cac cgg ggg gta gct gaa gcc cac ggc cgc 23004 Leu Leu Gly Asp Pro His Arg Gly Val Ala Glu Ala His Gly Arg 4280 4285 4290 cag ctc ctc ctc ggc ctg cct ttc gtc ctc gct gtc ctg gct gac 23049 Gln Leu Leu Leu Gly Leu Pro Phe Val Leu Ala Val Leu Ala Asp 4295 4300 4305 gtc ctg cag gac cac atg ctt ggt ctt gcg ggg ttt ctt ctt ggg 23094 Val Leu Gln Asp His Met Leu Gly Leu Ala Gly Phe Leu Leu Gly 4310 4315 4320 cgg cag cgg cgg cgg aga tgc ttg tgg cga ggg gga gcg cga gtt 23139 Arg Gln Arg Arg Arg Arg Cys Leu Trp Arg Gly Gly Ala Arg Val 4325 4330 4335 ctc gct cac cac tac tat ctc ttc ctc ttc gtg gtc cga ggc cac 23184 Leu Ala His His Tyr Tyr Leu Phe Leu Phe Val Val Arg Gly His 4340 4345 4350 gcg gcg gta ggt atg tct ctt cgg ggg cag agg cgg agg cga cgg 23229 Ala Ala Val Gly Met Ser Leu Arg Gly Gln Arg Arg Arg Arg Arg 4355 4360 4365 gct ctc gcc gcc gcg act tgg cgg atg gct ggc aga gcc cct tcc 23274 Ala Leu Ala Ala Ala Thr Trp Arg Met Ala Gly Arg Ala Pro Ser 4370 4375 4380 gcg atc ggg ggt gcg ctc ccg gcg gcg ctc tga ctg act tcc tcc 23319 Ala Ile Gly Gly Ala Leu Pro Ala Ala Leu Leu Thr Ser Ser 4385 4390 4395 gcg gcc ggc cat tgtgttctcc tagggaggaa caacaagcat ggagactcag 23371 Ala Ala Gly His 4400 ccatcgccaa cctcgccatc tgcccccacc accgccgacg agaagcagca gaatgaaagc 23431 ttaaccgccc cgccgcccag ccccgccacc tccgacgcag ccgcggtccc agacatgcaa 23491 gagatggagg aatccatcga gattgacctg ggctatgtga cgcccgcgga gcacgaggag 23551 gagctggcag tgcgctttca atcgtcaagc caggaagata aagaacagcc agagcaggaa 23611 gcagaaaacg agcagagtca ggctgggctc gagcatgacg gcgactacct ccacctgagc 23671 ggggaggagg acgcgctcat caagcatctg gcccggcagg ccatcatcgt caaggatgcg 23731 ctgctcgacc gcaccgaggt gcccctcagc gtggaggagc tcagccgcgc ctacgagctc 23791 aacctcttct cgccgcgcgt gccccccaag cgccagccca acggcacctg cgagcccaac 23851 ccgcgcctca acttctaccc ggtcttcgcg gtgcccgagg ccctggccac ctaccacatc 23911 tttttcaaga accaaaagat ccccgtctcc tgtcgcgcca accgcacccg cgccgacgcc 23971 ctcttcaacc tgggccccgg cgcccgccta cctgatatcg cctccttgga agaggttccc 24031 aagatcttcg agggtctggg cagcgacgag actcgggccg caaacgctct gcaaggagaa 24091 ggaggagagc atgagcacca cagcgccctg gtcgagttgg aaggcgacaa cgcgcggctg 24151 gcggtgctca aacgcacggt cgagctgacc catttcgcct acccggctct gaacctgccc 24211 cccaaagtca tgagcgcggt catggaccag gtgctcatca agcgcgcgtc gcccatctcc 24271 gaggacgagg gcatgcaaga ctccgaggat ggcaagcccg tggtcagcga cgagcagctg 24331 gcccggtggc tgggtcctaa tgctagtccc cagagtttgg aagagcggcg caagctcatg 24391 atggccgtgg tcctggtgac cgtggagctg gagtgcctgc gccgcttctt cgccgacgcg 24451 gagaccctgc gcaaggtcga ggagaacctg cactacctct tcaggcacgg gttcgtgcgc 24511 caggcctgca agatctccaa cgtggagctg accaacctgg tctcctacat gggcatcttg 24571 cacgagaacc gcctggggca gaacgtgctg cacaccaccc tgcgcgggga ggcccgccgc 24631 gactacatcc gcgactgcgt ctacctctac ctctgccaca cctggcagac gggcatgggc 24691 gtgtggcagc agtgtctgga ggagcagaac ctgaaagagc tctgcaagct cctgcagaag 24751 aacctcaagg gtctgtggac cgggttcgac gagcggacca ccgcctcgga cctggccgac 24811 ctcatcttcc ccgagcgcct caggctgacg ctgcgcaacg gcctgcccga ctttatgagc 24871 caaagcatgt tgcaaaactt tcgctctttc atcctcgaac gctccggaat cctgcccgcc 24931 acctgctccg cgctgccctc ggacttcgtg ccgctgacct tccgcgagtg ccccccgccg 24991 ctgtggagcc actgctacct gctgcgcctg gccaactacc tggcctacca ctcggacgtg 25051 atcgaggacg tcagcggcga gggcctgctt gagtgccact gccgctgcaa cctctgcacg 25111 ccgcaccgct ccctggcctg caacccccag ctgctgagcg agacccagat catcggcacc 25171 ttcgagttgc aagggcccag cgatgacggc gagggagcca aggggggtct gaaactcacc 25231 ccggggctgt ggacctcggc ctacttgcgc aagttcgtgc ccgaggacta ccatcccttc 25291 gagatcaggt tctacgagga ccaatcccag ccgcctaagg ccgagctgtc ggcctgcgtc 25351 atcacccagg gggccatcct ggcccaattg caagccatcc agaaatcccg ccaagaattc 25411 ttgctgaaaa agggccgcgg ggtctacctc gacccccaga ccggtgagga gctcaacccc 25471 ggcttccccc agg atg ccc cga gga aac aag aag ctg aaa gtg gag ctg 25520 Met Pro Arg Gly Asn Lys Lys Leu Lys Val Glu Leu 4405 4410 ccg ccc gtg gag gat ttg gag gaa gac tgg gag aac agc agt cag 25565 Pro Pro Val Glu Asp Leu Glu Glu Asp Trp Glu Asn Ser Ser Gln 4415 4420 4425 gca gag gag gag atg gag gaa gac tgg gac agc act cag gca gag 25610 Ala Glu Glu Glu Met Glu Glu Asp Trp Asp Ser Thr Gln Ala Glu 4430 4435 4440 gag gac agc ctg caa gac agt ctg gag gaa gac gag gag gag gca 25655 Glu Asp Ser Leu Gln Asp Ser Leu Glu Glu Asp Glu Glu Glu Ala 4445 4450 4455 gag gtg gaa gaa gca gcc gcc gcc aga ccg tcg tcc tcg gcg ggg 25700 Glu Val Glu Glu Ala Ala Ala Ala Arg Pro Ser Ser Ser Ala Gly 4460 4465 4470 gag aaa gca agc agc acg gat acc atc tcc gct ccg ggt cgg ggt 25745 Glu Lys Ala Ser Ser Thr Asp Thr Ile Ser Ala Pro Gly Arg Gly 4475 4480 4485 ccc gct cgg ccc cac agt aga tgg gac gag acc ggg cga ttc ccg 25790 Pro Ala Arg Pro His Ser Arg Trp Asp Glu Thr Gly Arg Phe Pro 4490 4495 4500 aac ccc acc atc cag acc ggt aag aag gag cgg cag gga tac aag 25835 Asn Pro Thr Ile Gln Thr Gly Lys Lys Glu Arg Gln Gly Tyr Lys 4505 4510 4515 tcc tgg cgg ggg cac aaa aac gcc atc gtc tcc tgc ttg cag gcc 25880 Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser Cys Leu Gln Ala 4520 4525 4530 tgc ggg ggc aac atc tcc ttc acc agg cgc tac ctg ctc ttc cac 25925 Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu Leu Phe His 4535 4540 4545 cgc ggg gtg aac ttc ccc cgc aac atc ttg cat tac tac cgt cac 25970 Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr Arg His 4550 4555 4560 ctc cac agc ccc tac tac ttc caa gaa gag gca gca gca gaa aaa 26015 Leu His Ser Pro Tyr Tyr Phe Gln Glu Glu Ala Ala Ala Glu Lys 4565 4570 4575 gac cag cag aaa acc agc agc tagaaaatcc acagcggcag caggtggact 26066 Asp Gln Gln Lys Thr Ser Ser 4580 4585 gaggatcgcg gcgaacgagc cggcgcagac ccgggagctg aggaaccgga tctttcccac 26126 cctctatgcc atcttccagc agagtcgggg gcaggagcag gaactgaaag tcaagaaccg 26186 ttctctgcgc tcgctcaccc gcagttgtct gtatcacaag agcgaagacc aacttcagcg 26246 cactctcgag gacgccgagg ctctcttcaa caagtactgc gcgctcactc ttaaagagta 26306 gcccgcgccc gcccagtcgc agaaaaaggc gggaattacg tcacctgtgc ccttcgccct 26366 agccgcctcc acccatc atg agc aaa gag att ccc acg cct tac atg tgg 26416 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp 4590 4595 agc tac cag ccc cag atg ggc ctg gcc gcc ggc gcc gcc cag gac 26461 Ser Tyr Gln Pro Gln Met Gly Leu Ala Ala Gly Ala Ala Gln Asp 4600 4605 4610 tac tcc acc cgc atg aat tgg ctc agc gcc ggg ccc gcg atg atc 26506 Tyr Ser Thr Arg Met Asn Trp Leu Ser Ala Gly Pro Ala Met Ile 4615 4620 4625 tca cgg gtg aat gac atc cgc gcc cac cga aac cag ata ctc cta 26551 Ser Arg Val Asn Asp Ile Arg Ala His Arg Asn Gln Ile Leu Leu 4630 4635 4640 gaa cag tca gcg ctc acc gcc acg ccc cgc aat cac ctc aat ccg 26596 Glu Gln Ser Ala Leu Thr Ala Thr Pro Arg Asn His Leu Asn Pro 4645 4650 4655 cgt aat tgg ccc gcc gcc ctg gtg tac cag gaa att ccc cag ccc 26641 Arg Asn Trp Pro Ala Ala Leu Val Tyr Gln Glu Ile Pro Gln Pro 4660 4665 4670 acg acc gta cta ctt ccg cga gac gcc cag gcc gaa gtc cag ctg 26686 Thr Thr Val Leu Leu Pro Arg Asp Ala Gln Ala Glu Val Gln Leu 4675 4680 4685 act aac tca ggt gtc cag ctg gcg ggc ggc gcc acc ctg tgt cgt 26731 Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala Thr Leu Cys Arg 4690 4695 4700 cac cgc ccc gct cag ggt ata aag cgg ctg gtg atc cgg ggc aga 26776 His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile Arg Gly Arg 4705 4710 4715 ggc aca cag ctc aac gac gag gtg gtg agc tct tcg ctg ggt ctg 26821 Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu Gly Leu 4720 4725 4730 cga cct gac gga gtc ttc caa atc gcc gga tcg ggg aga tct tcc 26866 Arg Pro Asp Gly Val Phe Gln Ile Ala Gly Ser Gly Arg Ser Ser 4735 4740 4745 ttc acg cct cgt cag gcg gtc ctg act ttg gag agt tcg tcc tcg 26911 Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 4750 4755 4760 cag ccc cgc tcg ggc ggc atc ggc act ctc cag ttc gtg gag gag 26956 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu 4765 4770 4775 ttc act ccc tcg gtc tac ttc aac ccc ttc tcc ggc tcc ccc ggc 27001 Phe Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly 4780 4785 4790 cac tac ccg gac gag ttc atc ccg aac ttt gac gcc atc agc gag 27046 His Tyr Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu 4795 4800 4805 tcg gtg gac ggc tac gat tga atg tcc cat ggt ggc gcg gct gac 27091 Ser Val Asp Gly Tyr Asp Met Ser His Gly Gly Ala Ala Asp 4810 4815 4820 cta gct cgg ctt cga cac ctg gac cac tgc cgc cgc ttt cgc tgc 27136 Leu Ala Arg Leu Arg His Leu Asp His Cys Arg Arg Phe Arg Cys 4825 4830 4835 ttc gct cgg gac ctc gcc gag ttc acc tac ttc gag ctg ccc gag 27181 Phe Ala Arg Asp Leu Ala Glu Phe Thr Tyr Phe Glu Leu Pro Glu 4840 4845 4850 gag cat cct cag ggc ccg gcc cac gga gtg cgg atc gtc gtc gaa 27226 Glu His Pro Gln Gly Pro Ala His Gly Val Arg Ile Val Val Glu 4855 4860 4865 ggg ggc cta gac tcc cac ctg ctt cgg atc ttc agc cag cgc ccg 27271 Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe Ser Gln Arg Pro 4870 4875 4880 atc ctg gtc gag cgc caa cag ggc aac acc ctc ctg acc ctc tac 27316 Ile Leu Val Glu Arg Gln Gln Gly Asn Thr Leu Leu Thr Leu Tyr 4885 4890 4895 tgc atc tgc gac cac ccc ggc ctg cat gaa agt ctt tgt tgt ctg 27361 Cys Ile Cys Asp His Pro Gly Leu His Glu Ser Leu Cys Cys Leu 4900 4905 4910 ctg tgt act gag tat aat aaa agc tgagatcagc gactactccg gactcaactg 27415 Leu Cys Thr Glu Tyr Asn Lys Ser 4915 tggtgtttct gcatccatca accagtctct gaccttcacc gggaacgaga ccgagctcca 27475 gctccagtgt aagccccaca agaagtacct cacctggctg taccagggct ccccgatcgc 27535 cgttgttaac cactgcgacg acgacggagt cctgctgaac ggccccgcca accttacttt 27595 ttccacccgc agaagcaagc tactgctctt cagacccttc ctccccggga tctatcagtg 27655 catctcggga ccctgccatc acaccttcca cctgatcccg aataccacct cttccccagc 27715 accgctcccc actaacaacc aaactaacca ccaacgccac cgtcgagacc tttcctctga 27775 ttctaatacc actaccggag gtgagctccg aggtactaag aagtcctcac ctgggattta 27835 ttacggcccc tgggaggtgg tggggttaat agctttaggc ttagtagcgg gtgggctttt 27895 ggctctctgc tacctatacc tcccttgctg ttcctactta gtggtgcttt gttgctggtt 27955 taagaa atg ggg aag atc acc cta gtg tgc ggt gtg ctg gtg acg gtg 28003 Met Gly Lys Ile Thr Leu Val Cys Gly Val Leu Val Thr Val 4920 4925 4930 gtg ctt tcg att ctg gga ggg gga agc gcg gct gta gtg acg gag 28048 Val Leu Ser Ile Leu Gly Gly Gly Ser Ala Ala Val Val Thr Glu 4935 4940 4945 aag aag gcc gat ccc tgc ttg act ttc aat ccc gat aaa tgc cgg 28093 Lys Lys Ala Asp Pro Cys Leu Thr Phe Asn Pro Asp Lys Cys Arg 4950 4955 4960 ctg agt ttt cag cca gat ggc aat cgg tgc acg gtg ctg atc aag 28138 Leu Ser Phe Gln Pro Asp Gly Asn Arg Cys Thr Val Leu Ile Lys 4965 4970 4975 tgc gga tgg gaa tgc gag agc gtg gcg atc cag tat aaa aac aag 28183 Cys Gly Trp Glu Cys Glu Ser Val Ala Ile Gln Tyr Lys Asn Lys 4980 4985 4990 acg cgg aac aat act ctc gcg tcc aca tgg cag ccc ggg gac ccc 28228 Thr Arg Asn Asn Thr Leu Ala Ser Thr Trp Gln Pro Gly Asp Pro 4995 5000 5005 gag tgg tac acc gtc tct gtc cct ggt gct gac ggc tcc ctc cac 28273 Glu Trp Tyr Thr Val Ser Val Pro Gly Ala Asp Gly Ser Leu His 5010 5015 5020 acg gtg aac aac act ttc att ttt gag cac atg tgc gaa acc gcc 28318 Thr Val Asn Asn Thr Phe Ile Phe Glu His Met Cys Glu Thr Ala 5025 5030 5035 atg ttc atg agc aag cag tac ggt atg tgg ccc cca cga aaa gag 28363 Met Phe Met Ser Lys Gln Tyr Gly Met Trp Pro Pro Arg Lys Glu 5040 5045 5050 aat atc gtg gtc ttc tcc atc gct tac agc gcg tgc acg gtg cta 28408 Asn Ile Val Val Phe Ser Ile Ala Tyr Ser Ala Cys Thr Val Leu 5055 5060 5065 atc acc gcg atc gtg tgc ctg agc att cac atg ctc atc gct att 28453 Ile Thr Ala Ile Val Cys Leu Ser Ile His Met Leu Ile Ala Ile 5070 5075 5080 cgc ccc aga aat aat gcc gag aaa gag aaa cag cca taacacactt 28499 Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 5085 5090 ttttcacaca ccttgttttt tacagaca atg cgt ctg tta att ttt gtt atc 28551 Met Arg Leu Leu Ile Phe Val Ile 5095 5100 att aca ctc agc ttt aac tat gcc cat ggc tat gca aat ata caa 28596 Ile Thr Leu Ser Phe Asn Tyr Ala His Gly Tyr Ala Asn Ile Gln 5105 5110 5115 aaa acc ctc tat gta ggc tct gac tct aca tta gaa ggt act caa 28641 Lys Thr Leu Tyr Val Gly Ser Asp Ser Thr Leu Glu Gly Thr Gln 5120 5125 5130 tct caa gcc agg gtt tca tgg tat ttt tat aaa ggc tct gat gac 28686 Ser Gln Ala Arg Val Ser Trp Tyr Phe Tyr Lys Gly Ser Asp Asp 5135 5140 5145 cca att act ctt tgc aaa ggt gat cag ggg cgc ata aca aag cca 28731 Pro Ile Thr Leu Cys Lys Gly Asp Gln Gly Arg Ile Thr Lys Pro 5150 5155 5160 cct atc aca ttt agc tgc acc aga aca aac ctc acg ctt tta tcc 28776 Pro Ile Thr Phe Ser Cys Thr Arg Thr Asn Leu Thr Leu Leu Ser 5165 5170 5175 att aca aaa gaa tat gct ggc act tat tac agc aca aat ttt cat 28821 Ile Thr Lys Glu Tyr Ala Gly Thr Tyr Tyr Ser Thr Asn Phe His 5180 5185 5190 cgt ggg caa gat aaa tat tat act gtt aag gta gaa aac cct acc 28866 Arg Gly Gln Asp Lys Tyr Tyr Thr Val Lys Val Glu Asn Pro Thr 5195 5200 5205 acc cct aga aca act aca aag ccc acc aca act aag aag ccc act 28911 Thr Pro Arg Thr Thr Thr Lys Pro Thr Thr Thr Lys Lys Pro Thr 5210 5215 5220 aca cct aag aag cct acc aca ccc aaa acc act aag aca aca act 28956 Thr Pro Lys Lys Pro Thr Thr Pro Lys Thr Thr Lys Thr Thr Thr 5225 5230 5235 gct aag acc act acc aca aag cca acc aca acc agc acc aca ctt 29001 Ala Lys Thr Thr Thr Thr Lys Pro Thr Thr Thr Ser Thr Thr Leu 5240 5245 5250 gct ata act aca cac aca cac act gag ctg acc tca cag gca act 29046 Ala Ile Thr Thr His Thr His Thr Glu Leu Thr Ser Gln Ala Thr 5255 5260 5265 act gaa aat gat ttg gtt gcc ctg ttg caa aag ggg gag aac agt 29091 Thr Glu Asn Asp Leu Val Ala Leu Leu Gln Lys Gly Glu Asn Ser 5270 5275 5280 agc agc agt cct ctg cct act acc ccc agt gag gaa ata ccc aag 29136 Ser Ser Ser Pro Leu Pro Thr Thr Pro Ser Glu Glu Ile Pro Lys 5285 5290 5295 tcc atg gtt ggc att atc gct gct gta gtg gtg tgt atg ctg att 29181 Ser Met Val Gly Ile Ile Ala Ala Val Val Val Cys Met Leu Ile 5300 5305 5310 atc atc ttg tgc atg atg tac tat gcc tgc tac tac aga aaa cac 29226 Ile Ile Leu Cys Met Met Tyr Tyr Ala Cys Tyr Tyr Arg Lys His 5315 5320 5325 agg ctg aac aac aaa ctg gac ccc tta ctg agt gtt gat ttt 29268 Arg Leu Asn Asn Lys Leu Asp Pro Leu Leu Ser Val Asp Phe 5330 5335 5340 taatttttta gaacc atg aag atc cta agc ctt ttt gtt ttt tct ata 29316 Met Lys Ile Leu Ser Leu Phe Val Phe Ser Ile 5345 5350 att att acc tct gct att tgt gaa tca gtg gat aag gac gtt act 29361 Ile Ile Thr Ser Ala Ile Cys Glu Ser Val Asp Lys Asp Val Thr 5355 5360 5365 gtc acc act ggc tct aat tat aca cta aaa ggg cct tcc tca ggt 29406 Val Thr Thr Gly Ser Asn Tyr Thr Leu Lys Gly Pro Ser Ser Gly 5370 5375 5380 atg ctt tcg tgg tat tgt tat ttt gga aat gat gat aaa cag aca 29451 Met Leu Ser Trp Tyr Cys Tyr Phe Gly Asn Asp Asp Lys Gln Thr 5385 5390 5395 gag cta tgt aac ttt cag aac ggc aaa acc aaa aat tct aaa ata 29496 Glu Leu Cys Asn Phe Gln Asn Gly Lys Thr Lys Asn Ser Lys Ile 5400 5405 5410 gat aac tat caa tgc cag ggt act aat tta gta ctg atg aat atc 29541 Asp Asn Tyr Gln Cys Gln Gly Thr Asn Leu Val Leu Met Asn Ile 5415 5420 5425 acg aaa gca tat gct ggc agt tat tcc tgt cct gga caa aac acc 29586 Thr Lys Ala Tyr Ala Gly Ser Tyr Ser Cys Pro Gly Gln Asn Thr 5430 5435 5440 gag gaa atg att ttt tac aaa tta att gta gtt gac cct act act 29631 Glu Glu Met Ile Phe Tyr Lys Leu Ile Val Val Asp Pro Thr Thr 5445 5450 5455 cca gca cca ccc acc aca acc aag gca cat acc aca gac aca cag 29676 Pro Ala Pro Pro Thr Thr Thr Lys Ala His Thr Thr Asp Thr Gln 5460 5465 5470 gaa acc act cca gag gca gaa gta gca gag tta gca aag cag att 29721 Glu Thr Thr Pro Glu Ala Glu Val Ala Glu Leu Ala Lys Gln Ile 5475 5480 5485 cat gaa gat tca ttt gtt gcc aat acc ccc aca cac ccc gga ccg 29766 His Glu Asp Ser Phe Val Ala Asn Thr Pro Thr His Pro Gly Pro 5490 5495 5500 caa tgt cca ggg cca tta gtc agc ggc att gtc ggt gtg ctt tgc 29811 Gln Cys Pro Gly Pro Leu Val Ser Gly Ile Val Gly Val Leu Cys 5505 5510 5515 ggg tta gca gtt ata atc atc tgc atg ttc att ttt gct tgc tgc 29856 Gly Leu Ala Val Ile Ile Ile Cys Met Phe Ile Phe Ala Cys Cys 5520 5525 5530 tac aga agg ctt cac cga caa aaa tca gac cca ctg ctg aac ctc 29901 Tyr Arg Arg Leu His Arg Gln Lys Ser Asp Pro Leu Leu Asn Leu 5535 5540 5545 tat gtt taatttttga ttttccagag cc atg aag gca ctt agc act tta 29950 Tyr Val Met Lys Ala Leu Ser Thr Leu 5550 5555 gta ttt ttg tcc ttg att ggc att gtt ttc agt gct ggg ttt ttg 29995 Val Phe Leu Ser Leu Ile Gly Ile Val Phe Ser Ala Gly Phe Leu 5560 5565 5570 aaa aat ctt acc att att gaa ggt gat aat gca aca ctg gta gga 30040 Lys Asn Leu Thr Ile Ile Glu Gly Asp Asn Ala Thr Leu Val Gly 5575 5580 5585 atc agc ggt cag aat gtt agt tgg cta aaa tat cat cta gat ggg 30085 Ile Ser Gly Gln Asn Val Ser Trp Leu Lys Tyr His Leu Asp Gly 5590 5595 5600 tgg aaa cct att tgc acc tgg aat gtc agt gtg tac aca tgc cat 30130 Trp Lys Pro Ile Cys Thr Trp Asn Val Ser Val Tyr Thr Cys His 5605 5610 5615 ggt gtt aac ctc acc att acc aat gcc acc caa gat cag aat ggc 30175 Gly Val Asn Leu Thr Ile Thr Asn Ala Thr Gln Asp Gln Asn Gly 5620 5625 5630 agg ttt aag ggt cag agt ttc act agc aac aat ggg tat gaa acc 30220 Arg Phe Lys Gly Gln Ser Phe Thr Ser Asn Asn Gly Tyr Glu Thr 5635 5640 5645 cat aac atg ttc atc tat gat gtc act gtc ata tca aat aag act 30265 His Asn Met Phe Ile Tyr Asp Val Thr Val Ile Ser Asn Lys Thr 5650 5655 5660 aca cct acc aca cag aca ccc act aca cat agc tca act cat gcc 30310 Thr Pro Thr Thr Gln Thr Pro Thr Thr His Ser Ser Thr His Ala 5665 5670 5675 atg cag acc act cag aca acc aca tac act aca tct act gag tcc 30355 Met Gln Thr Thr Gln Thr Thr Thr Tyr Thr Thr Ser Thr Glu Ser 5680 5685 5690 acc acc acc act aca gca gag gta tcc agc aca gcg cct cag ccc 30400 Thr Thr Thr Thr Thr Ala Glu Val Ser Ser Thr Ala Pro Gln Pro 5695 5700 5705 cag gca ttg gct ttg atg gct cag cct agc agc atg act gct aaa 30445 Gln Ala Leu Ala Leu Met Ala Gln Pro Ser Ser Met Thr Ala Lys 5710 5715 5720 acc aat gag cag act act gaa ttt ttg tcc act att cag agc agc 30490 Thr Asn Glu Gln Thr Thr Glu Phe Leu Ser Thr Ile Gln Ser Ser 5725 5730 5735 acc aca gct acc tcg agt gcc ttc tct agc acc gcc aat ctc acc 30535 Thr Thr Ala Thr Ser Ser Ala Phe Ser Ser Thr Ala Asn Leu Thr 5740 5745 5750 tcg ctt tcc tct acg cca atc agt aac gct act acc tcc ccc gct 30580 Ser Leu Ser Ser Thr Pro Ile Ser Asn Ala Thr Thr Ser Pro Ala 5755 5760 5765 cct ctt ccc act cct ctg aag caa tcc gag tct agc acg cag ctg 30625 Pro Leu Pro Thr Pro Leu Lys Gln Ser Glu Ser Ser Thr Gln Leu 5770 5775 5780 cag atc acc ctg ctc att gtg atc ggg gtg gtc atc ctg gca gtg 30670 Gln Ile Thr Leu Leu Ile Val Ile Gly Val Val Ile Leu Ala Val 5785 5790 5795 ctg ctc tac ttt atc ttc tgc cgc cgc atc ccc aac gcg aaa ccg 30715 Leu Leu Tyr Phe Ile Phe Cys Arg Arg Ile Pro Asn Ala Lys Pro 5800 5805 5810 gcc tac aag ccc att gtt atc ggg acg ccg gag ccg ctt cag gtg 30760 Ala Tyr Lys Pro Ile Val Ile Gly Thr Pro Glu Pro Leu Gln Val 5815 5820 5825 gag gga ggt cta agg aat ctt ctc ttc tct ttt aca gta tgg 30802 Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser Phe Thr Val Trp 5830 5835 5840 tgatttgaac tatgattcct agacatttca ttatcacttc tctaatctgt gtgctccaag 30862 tctgtgccac cctcgctctc gtggctaacg cgagtccaga ctgcattgga gcgttcgcct 30922 cctacgtgct ctttgccttc atcacctgca tctgctgctg tagcatagtc tgcctgctta 30982 tcaccttctt ccagttcgtt gactgggtct ttgtgcgcat cgcctacctg cgccaccacc 31042 cccagtaccg cgaccagaga gtggcgcaac tgttgagact catctgatga taagcatgcg 31102 ggctctgcta ctacttctcg cgcttctgct agctcccctc gccgcccccc tatccctcaa 31162 atcccccacc cagtcccctg aagaggttcg aaaatgtaaa ttccaagaac cctggaaatt 31222 cctttcatgc tacaaactca aatcagaaat gcaccccagc tggatcatga tcgttggaat 31282 cgtaaacatc cttgcctgta ccctcttctc ctttgtgatt tacccccgct ttgactttgg 31342 gtggaacgca cccgaggcgc tctggctccc gcctgatccc gacacaccac cacagcagca 31402 gcaaaatcag gcacaggcac atgcaccacc acagcctagg ccacaataca tgcccatctt 31462 agactatgag gccgagccac agcgagccat gcttcctgct attagttact tcaatctaac 31522 cggcggag atg act gac ccc atg gcc aac aac acc gtc aac gac ctc 31569 Met Thr Asp Pro Met Ala Asn Asn Thr Val Asn Asp Leu 5845 5850 ctg gac atg gac ggc cgc gcc tcg gag cag cga ctc gcc caa ctc 31614 Leu Asp Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu 5855 5860 5865 cgc atc cgc cag cag cag gag aga gcc gtc aag gag ctg cag gac 31659 Arg Ile Arg Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp 5870 5875 5880 gcg gtg gcc atc cac cag tgc aag aga ggc atc ttc tgc ctg gtg 31704 Ala Val Ala Ile His Gln Cys Lys Arg Gly Ile Phe Cys Leu Val 5885 5890 5895 aag cag gcc aag atc tcc ttc gag gtc acg tcc acc gac cat cgc 31749 Lys Gln Ala Lys Ile Ser Phe Glu Val Thr Ser Thr Asp His Arg 5900 5905 5910 ctc tcc tac gag ctc ctg cag cag cgc cag aag ttc acc tgc ctg 31794 Leu Ser Tyr Glu Leu Leu Gln Gln Arg Gln Lys Phe Thr Cys Leu 5915 5920 5925 gtc gga gtc aac ccc atc gtc atc acc cag cag tct ggc gat acc 31839 Val Gly Val Asn Pro Ile Val Ile Thr Gln Gln Ser Gly Asp Thr 5930 5935 5940 aag ggt tgc atc cac tgc tcc tgc gac tcc ccc gag tgc gtt cac 31884 Lys Gly Cys Ile His Cys Ser Cys Asp Ser Pro Glu Cys Val His 5945 5950 5955 acc ctg atc aag acc ctc tgc ggc ctc cgc gac ctc ctc ccc atg 31929 Thr Leu Ile Lys Thr Leu Cys Gly Leu Arg Asp Leu Leu Pro Met 5960 5965 5970 aac taatcaacta accccctacc cctttaccct ccagtaaaaa taaagattaa 31982 Asn aaatgattga attgatcaat aaagaatcac ttacttgaaa tctgaaacca ggtctctgtc 32042 c atg ttt tct gtc agc agc act tca ctc ccc tct tcc caa ctc tgg 32088 Met Phe Ser Val Ser Ser Thr Ser Leu Pro Ser Ser Gln Leu Trp 5975 5980 5985 tac tgc agg ccc cgg cgg gct gca aac ttc ctc cac act ctg aag 32133 Tyr Cys Arg Pro Arg Arg Ala Ala Asn Phe Leu His Thr Leu Lys 5990 5995 6000 ggg atg tca aat tcc tcc tgt ccc tca atc ttc att ttt atc ttc 32178 Gly Met Ser Asn Ser Ser Cys Pro Ser Ile Phe Ile Phe Ile Phe 6005 6010 6015 tat cag atg tcc aaa aag cgc gcg cgg gtg gat gat ggc ttc gac 32223 Tyr Gln Met Ser Lys Lys Arg Ala Arg Val Asp Asp Gly Phe Asp 6020 6025 6030 ccc gtg tac ccc tac gat gca gac aac gca ccg act gtg ccc ttc 32268 Pro Val Tyr Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe 6035 6040 6045 atc aac cct ccc ttc gtc tct tca gat gga ttc caa gaa aag ccc 32313 Ile Asn Pro Pro Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro 6050 6055 6060 ctg ggg gtg ttg tcc ctg cga ctg gcc gac ccc gtc acc acc aag 32358 Leu Gly Val Leu Ser Leu Arg Leu Ala Asp Pro Val Thr Thr Lys 6065 6070 6075 aat ggg gct gtc acc ctc aag ctg ggg gag ggg gtg gac ctc gac 32403 Asn Gly Ala Val Thr Leu Lys Leu Gly Glu Gly Val Asp Leu Asp 6080 6085 6090 gac tcg gga aaa ctc atc tcc aaa aat gcc acc aag gcc act gcc 32448 Asp Ser Gly Lys Leu Ile Ser Lys Asn Ala Thr Lys Ala Thr Ala 6095 6100 6105 cct ctc agt att tcc aac ggc acc att tcc ctt aac atg gcc gcc 32493 Pro Leu Ser Ile Ser Asn Gly Thr Ile Ser Leu Asn Met Ala Ala 6110 6115 6120 cct ttt tac aac aac aat gga acg tta agt ctc aat gtt tct aca 32538 Pro Phe Tyr Asn Asn Asn Gly Thr Leu Ser Leu Asn Val Ser Thr 6125 6130 6135 cca tta gca gta ttt ccc act ttt aac act tta ggt atc agt ctt 32583 Pro Leu Ala Val Phe Pro Thr Phe Asn Thr Leu Gly Ile Ser Leu 6140 6145 6150 gga aac ggt ctt caa act tct aat aag ttg ctg act gta cag tta 32628 Gly Asn Gly Leu Gln Thr Ser Asn Lys Leu Leu Thr Val Gln Leu 6155 6160 6165 act cat cct ctt aca ttc agc tca aat agc atc aca gta aaa aca 32673 Thr His Pro Leu Thr Phe Ser Ser Asn Ser Ile Thr Val Lys Thr 6170 6175 6180 gac aaa gga ctc tat att aat tct agt gga aac aga ggg ctt gag 32718 Asp Lys Gly Leu Tyr Ile Asn Ser Ser Gly Asn Arg Gly Leu Glu 6185 6190 6195 gct aac ata agc cta aaa aga gga ctg att ttt gat ggt aat gct 32763 Ala Asn Ile Ser Leu Lys Arg Gly Leu Ile Phe Asp Gly Asn Ala 6200 6205 6210 att gca aca tac ctt gga agt ggt tta gac tat gga tcc tat gat 32808 Ile Ala Thr Tyr Leu Gly Ser Gly Leu Asp Tyr Gly Ser Tyr Asp 6215 6220 6225 agc gat ggg aaa aca aga ccc atc atc acc aaa att gga gca ggt 32853 Ser Asp Gly Lys Thr Arg Pro Ile Ile Thr Lys Ile Gly Ala Gly 6230 6235 6240 ttg aat ttt gat gct aat aat gcc atg gct gtg aag cta ggc aca 32898 Leu Asn Phe Asp Ala Asn Asn Ala Met Ala Val Lys Leu Gly Thr 6245 6250 6255 ggt tta agt ttt gac tct gcc ggt gcc tta aca gct gga aac aaa 32943 Gly Leu Ser Phe Asp Ser Ala Gly Ala Leu Thr Ala Gly Asn Lys 6260 6265 6270 gag gat gac aag cta aca ctt tgg act aca cct gac cca agc cct 32988 Glu Asp Asp Lys Leu Thr Leu Trp Thr Thr Pro Asp Pro Ser Pro 6275 6280 6285 aat tgt caa tta ctt tca gac aga gat gcc aaa ttt acc cta tgt 33033 Asn Cys Gln Leu Leu Ser Asp Arg Asp Ala Lys Phe Thr Leu Cys 6290 6295 6300 ctt aca aaa tgc ggt agt caa ata cta ggc act gtt gca gta gct 33078 Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Ala Val Ala 6305 6310 6315 gct gtt act gta ggt tca gca cta aat cca att aat gac aca gta 33123 Ala Val Thr Val Gly Ser Ala Leu Asn Pro Ile Asn Asp Thr Val 6320 6325 6330 aaa agc gcc ata gta ttc ctt aga ttt gac tct gac ggt gtg ctc 33168 Lys Ser Ala Ile Val Phe Leu Arg Phe Asp Ser Asp Gly Val Leu 6335 6340 6345 atg tca aac tca tca atg gta ggt gat tac tgg aac ttt agg gaa 33213 Met Ser Asn Ser Ser Met Val Gly Asp Tyr Trp Asn Phe Arg Glu 6350 6355 6360 gga cag acc acc caa agt gtg gcc tat aca aat gct gtg gga ttc 33258 Gly Gln Thr Thr Gln Ser Val Ala Tyr Thr Asn Ala Val Gly Phe 6365 6370 6375 atg ccc aat cta ggt gca tat cct aaa acc caa agc aaa aca cca 33303 Met Pro Asn Leu Gly Ala Tyr Pro Lys Thr Gln Ser Lys Thr Pro 6380 6385 6390 aaa aat agt ata gta agt cag gta tat tta aat gga gaa act act 33348 Lys Asn Ser Ile Val Ser Gln Val Tyr Leu Asn Gly Glu Thr Thr 6395 6400 6405 atg cca atg aca ctg aca ata act ttc aat ggc act gat gaa aaa 33393 Met Pro Met Thr Leu Thr Ile Thr Phe Asn Gly Thr Asp Glu Lys 6410 6415 6420 gac aca aca cct gtg agc act tac tcc atg act ttt aca tgg cag 33438 Asp Thr Thr Pro Val Ser Thr Tyr Ser Met Thr Phe Thr Trp Gln 6425 6430 6435 tgg act gga gac tat aag gac aag aat att acc ttt gct acc aac 33483 Trp Thr Gly Asp Tyr Lys Asp Lys Asn Ile Thr Phe Ala Thr Asn 6440 6445 6450 tcc ttt act ttc tcc tac atg gcc caa gaa taaaccctgc atgccaaccc 33533 Ser Phe Thr Phe Ser Tyr Met Ala Gln Glu 6455 6460 cattgttccc accactatgg aaaactctga agcagaaaaa aataaagttc aagtgtttta 33593 ttgattcaac agttttcaca gaattcgagt agttattttc cctcctccct cccaactcat 33653 ggaatacacc accctctccc cacgcacagc cttaaacatc tgaatgccat tggtaatgga 33713 catggttttg gtctccacat tccacacagt ttcagagcga gccagtctcg ggtcggtcag 33773 ggagatgaaa ccctccgggc actcctgcat ctgcacctca aagttcagta gctgagggct 33833 gtcctcggtg gtcgggatca cagtta tct gga aga aga gcg gtg aga gtc 33883 Ser Gly Arg Arg Ala Val Arg Val 6465 6470 ata atc cgc gaa cgg gat cgg gcg gtt gtg gcg cat cag gcc ccg 33928 Ile Ile Arg Glu Arg Asp Arg Ala Val Val Ala His Gln Ala Pro 6475 6480 6485 cag cag tcg ctg tct gcg ccg ctc cgt caa gct gct gct caa ggg 33973 Gln Gln Ser Leu Ser Ala Pro Leu Arg Gln Ala Ala Ala Gln Gly 6490 6495 6500 gtc tgg gtc cag gga ctc cct gcg cat gat gcc gat ggc cct gag 34018 Val Trp Val Gln Gly Leu Pro Ala His Asp Ala Asp Gly Pro Glu 6505 6510 6515 cat cag tcg cct ggt gcg gcg ggc gca gca gcg gat gcg gat ctc 34063 His Gln Ser Pro Gly Ala Ala Gly Ala Ala Ala Asp Ala Asp Leu 6520 6525 6530 act cag gtc gga gca gta cgt gca gca cag cac tac caa gtt gtt 34108 Thr Gln Val Gly Ala Val Arg Ala Ala Gln His Tyr Gln Val Val 6535 6540 6545 caa cag tcc ata gtt caa cgt gct cca gcc aaa act cat ctg tgg 34153 Gln Gln Ser Ile Val Gln Arg Ala Pro Ala Lys Thr His Leu Trp 6550 6555 6560 aac tat gct gcc cac atg tcc atc gta cca gat cct gat gta aat 34198 Asn Tyr Ala Ala His Met Ser Ile Val Pro Asp Pro Asp Val Asn 6565 6570 6575 cag gtg gcg ccc cct cca gaa cac act gcc cat gta cat gat ctc 34243 Gln Val Ala Pro Pro Pro Glu His Thr Ala His Val His Asp Leu 6580 6585 6590 ctt ggg cat gtg cag gtt cac cac ctc ccg gta cca cat cac ccg 34288 Leu Gly His Val Gln Val His His Leu Pro Val Pro His His Pro 6595 6600 6605 ctg gtt gaa cat gca gcc ctg gat aat cct gcg gaa cca gat ggc 34333 Leu Val Glu His Ala Ala Leu Asp Asn Pro Ala Glu Pro Asp Gly 6610 6615 6620 cag cac cgc ccc gcc cgc cat gca gcg cag gga ccc cgg gtc ctg 34378 Gln His Arg Pro Ala Arg His Ala Ala Gln Gly Pro Arg Val Leu 6625 6630 6635 gca atg gca gtg gag cac cca ccg ctc acg gcc gtg gat taa ctg 34423 Ala Met Ala Val Glu His Pro Pro Leu Thr Ala Val Asp Leu 6640 6645 6650 gga gct gaa caa gtc tat gtt ggc aca gca cag gca cac gct cat 34468 Gly Ala Glu Gln Val Tyr Val Gly Thr Ala Gln Ala His Ala His 6655 6660 6665 gca tgt ctt cag cac tct cag ttc ctc ggg ggt cag gac cat gtc 34513 Ala Cys Leu Gln His Ser Gln Phe Leu Gly Gly Gln Asp His Val 6670 6675 6680 cca ggg cac ggg gaa ctc ttg cag gac agt gaa ccc ggc aga aca 34558 Pro Gly His Gly Glu Leu Leu Gln Asp Ser Glu Pro Gly Arg Thr 6685 6690 6695 ggg cag ccc tcg cac aca act tac att gtg cat gga cag ggt atc 34603 Gly Gln Pro Ser His Thr Thr Tyr Ile Val His Gly Gln Gly Ile 6700 6705 6710 gca atc agg cag cac cgg atg atc ctc cac cag aga agc gcg ggt 34648 Ala Ile Arg Gln His Arg Met Ile Leu His Gln Arg Ser Ala Gly 6715 6720 6725 ctc ggt ctc ctc aca gcg agg taa ggg ggc cgg cgg ttg gta cgg 34693 Leu Gly Leu Leu Thr Ala Arg Gly Gly Arg Arg Leu Val Arg 6730 6735 6740 atg atg gcg gga tga cgc taa tcg tgt tct gga tcg tgt cat gat gga 34741 Met Met Ala Gly Arg Ser Cys Ser Gly Ser Cys His Asp Gly 6745 6750 gct gtt tcc tga cat tttcgtactt cacgaagcag aacctggtac gggcactgca 34796 Ala Val Ser His 6755 caccgctcgc cggcgacggt ctcggcgctt cgagcgctcg gtgttgaagt tatagaacag 34856 ccactccctc agagcgtgca gtatctcctg agcctcttgg gtgatgaaaa tcccatccgc 34916 tctgatggct ctgatcacat cggccacggt ggaatgggcc agacccagcc agatgatgca 34976 attttgttgg gtttcggtga cggagggaga gggaagaaca ggaagaacca tgattaactt 35036 ta ttc caa acg gtc tcg gag cac ttc aaa atg cag gtc ccg gag gtg 35083 Phe Gln Thr Val Ser Glu His Phe Lys Met Gln Val Pro Glu Val 6760 6765 6770 gca cct ctc gcc ccc act gtg ttg gtg gaa aat aac agc cag gtc 35128 Ala Pro Leu Ala Pro Thr Val Leu Val Glu Asn Asn Ser Gln Val 6775 6780 6785 aaa ggt gac acg gtt ctc gag atg ttc cac ggt ggc ttc cag caa 35173 Lys Gly Asp Thr Val Leu Glu Met Phe His Gly Gly Phe Gln Gln 6790 6795 6800 agc ctc cac gcg cac atc cag aaa caa gag gac agc gaa agc ggg 35218 Ser Leu His Ala His Ile Gln Lys Gln Glu Asp Ser Glu Ser Gly 6805 6810 6815 agc gtt ttc taa ttc ctc aat cat cat att aca ctc ctg cac cat 35263 Ser Val Phe Phe Leu Asn His His Ile Thr Leu Leu His His 6820 6825 6830 ccc cag ata att ttc att ttt cca gcc ttg aat gat tcg tat tag 35308 Pro Gln Ile Ile Phe Ile Phe Pro Ala Leu Asn Asp Ser Tyr 6835 6840 6845 ttc ctg agg taa atc caa gcc agc cat gat aaa aag ctc gcg cag 35353 Phe Leu Arg Ile Gln Ala Ser His Asp Lys Lys Leu Ala Gln 6850 6855 6860 agc gcc ctc cac cgg cat tct taa gca cac cct cat aattccaaga 35399 Ser Ala Leu His Arg His Ser Ala His Pro His 6865 6870 gattctgctc ctggttcacc tgcagcagat taacaatggg aatatcaaaa tctctgccgc 35459 gatccctaag ctcctccctc aacaataact gtatgtaatc tttcatatca tctccgaaat 35519 ttttagccat agggccgcca ggaataagag cagggcaagc cacattacag ataaagcgaa 35579 gtcctcccca gtgagcattg ccaaatgtaa gattgaaata agcatgctgg ctagaccctg 35639 tgatatcttc cagataactg gacagaaaat caggcaagca atttttaaga aaatcaacaa 35699 aagaaaagtc gtccaggtgc aggtttagag cctcaggaac aacgatggaa taagtgcaag 35759 gagtgcgttc cagcatggtt agtgtttttt tggtgatctg tagaacaaaa aataaacatg 35819 caatatta aac cat gct agc ctg gcg aac agg tgg gta aat cac tct 35866 Asn His Ala Ser Leu Ala Asn Arg Trp Val Asn His Ser 6875 6880 ttc cag cac cag gca ggc tac ggg gtc tcc ggc gcg acc ctc gta 35911 Phe Gln His Gln Ala Gly Tyr Gly Val Ser Gly Ala Thr Leu Val 6885 6890 6895 gaa gct gtc gcc atg att gaa aag cat cac cga gag acc ttc ccg 35956 Glu Ala Val Ala Met Ile Glu Lys His His Arg Glu Thr Phe Pro 6900 6905 6910 gtg gcc ggc atg gat gat tcg aga aga agc ata cac tcc ggg aac 36001 Val Ala Gly Met Asp Asp Ser Arg Arg Ser Ile His Ser Gly Asn 6915 6920 6925 att ggc atc cgt gag tga aaa aaa gcg acc tat aaa gcc tcg ggg 36046 Ile Gly Ile Arg Glu Lys Lys Ala Thr Tyr Lys Ala Ser Gly 6930 6935 6940 cac tac aat gct caa tct caa ttc cag caa agc cac ccc atg cgg 36091 His Tyr Asn Ala Gln Ser Gln Phe Gln Gln Ser His Pro Met Arg 6945 6950 6955 atg gag cac aaa att ggc agg tgc gta aaa aat gta att act ccc 36136 Met Glu His Lys Ile Gly Arg Cys Val Lys Asn Val Ile Thr Pro 6960 6965 6970 ctc ctg cac agg cag caa agc ccc cgc tcc ctc cag aaa cac ata 36181 Leu Leu His Arg Gln Gln Ser Pro Arg Ser Leu Gln Lys His Ile 6975 6980 6985 caa agc ctc agc gtc cat agcttaccga gcacggcagg cgcaagagtc 36229 Gln Ser Leu Ser Val His 6990 agagaaaagg ctgagctcta acctgactgc ccgctcctgt gctcaatata tagccctaac 36289 ctacactgac gtaaaggcca aagtctaaaa atacccgcca aaatgacaca cacgcccagc 36349 acacgcccag aaaccggtga cacactcaaa aaaatacgtg cgcttcctca aacgcccaaa 36409 ccggcgtcat ttccgggttc ccacgctacg tcaccgctca gcgactttca aattccgtcg 36469 accgttaaaa acgtcactcg ccccgcccct aacggtcgcc cttctctcgg ccaatcacct 36529 tcctcccttc ccaaattcaa acgcctcatt tgcatattaa cgcgcacaaa aagtttgagg 36589 tatattattg atgatgatcg tttaaactat gcggtgtgaa ataccgcaca gatgcgtaag 36649 gagaaaatac cgcatcaggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt 36709 cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga 36769 atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg 36829 taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa 36889 aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt 36949 tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct 37009 gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct 37069 cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc 37129 cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt 37189 atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc 37249 tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag tatttggtat 37309 ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa 37369 acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa 37429 aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga 37489 aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct 37549 tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga 37609 cag tta cca atg ctt aat cag tga ggc acc tat ctc agc gat ctg 37654 Leu Pro Met Leu Asn Gln Gly Thr Tyr Leu Ser Asp Leu 6995 7000 7005 tct att tcg ttc atc cat agt tgc ctg act ccc cgt cgt gta gat 37699 Ser Ile Ser Phe Ile His Ser Cys Leu Thr Pro Arg Arg Val Asp 7010 7015 7020 aac tac gat acg gga ggg ctt acc atc tgg ccc cag tgc tgc aat 37744 Asn Tyr Asp Thr Gly Gly Leu Thr Ile Trp Pro Gln Cys Cys Asn 7025 7030 7035 gat acc gcg aga ccc acg ctc acc ggc tcc aga ttt atc agc aat 37789 Asp Thr Ala Arg Pro Thr Leu Thr Gly Ser Arg Phe Ile Ser Asn 7040 7045 7050 aaa cca gcc agc cgg aag ggc cga gcg cag aag tgg tcc tgc aac 37834 Lys Pro Ala Ser Arg Lys Gly Arg Ala Gln Lys Trp Ser Cys Asn 7055 7060 7065 ttt atc cgc ctc cat cca gtc tat taa ttg ttg ccg gga agc tag 37879 Phe Ile Arg Leu His Pro Val Tyr Leu Leu Pro Gly Ser 7070 7075 7080 agt aag tag ttc gcc agt taa tag ttt gcg caa cgt tgt tgc cat tgc 37927 Ser Lys Phe Ala Ser Phe Ala Gln Arg Cys Cys His Cys 7085 7090 tgc agg cat cgt ggt gtc acg ctc gtc gtt tgg tat ggc ttc att 37972 Cys Arg His Arg Gly Val Thr Leu Val Val Trp Tyr Gly Phe Ile 7095 7100 7105 cag ctc cgg ttc cca acg atc aag gcg agt tac atg atc ccc cat 38017 Gln Leu Arg Phe Pro Thr Ile Lys Ala Ser Tyr Met Ile Pro His 7110 7115 7120 gtt gtg caa aaa agc ggt tag ctc ctt cgg tcc tcc gat cgt tgt 38062 Val Val Gln Lys Ser Gly Leu Leu Arg Ser Ser Asp Arg Cys 7125 7130 7135 cag aag taa gtt ggc cgc agt gtt atc act cat ggt tat ggc agc 38107 Gln Lys Val Gly Arg Ser Val Ile Thr His Gly Tyr Gly Ser 7140 7145 7150 act gca taa ttc tct tac tgt cat gcc atc cgt aag atg ctt ttc 38152 Thr Ala Phe Ser Tyr Cys His Ala Ile Arg Lys Met Leu Phe 7155 7160 7165 tgt gac tgg tga gta ctc aac caa gtc att ctg aga ata gtg tat 38197 Cys Asp Trp Val Leu Asn Gln Val Ile Leu Arg Ile Val Tyr 7170 7175 gcg gcg acc gag ttg ctc ttg ccc ggc gtc aac acg gga taa tac 38242 Ala Ala Thr Glu Leu Leu Leu Pro Gly Val Asn Thr Gly Tyr 7180 7185 7190 cgc gcc aca tag cag aac ttt aaa agt gct cat cat tgg aaa acg 38287 Arg Ala Thr Gln Asn Phe Lys Ser Ala His His Trp Lys Thr 7195 7200 7205 ttc ttc ggg gcg aaa act ctc aag gat ctt acc gct gtt gag atc 38332 Phe Phe Gly Ala Lys Thr Leu Lys Asp Leu Thr Ala Val Glu Ile 7210 7215 7220 cag ttc gat gta acc cac tcg tgc acc caa ctg atc ttc agc atc 38377 Gln Phe Asp Val Thr His Ser Cys Thr Gln Leu Ile Phe Ser Ile 7225 7230 7235 ttt tac ttt cac cag cgt ttc tgg gtg agc aaa aac agg aag gca 38422 Phe Tyr Phe His Gln Arg Phe Trp Val Ser Lys Asn Arg Lys Ala 7240 7245 7250 aaa tgc cgc aaa aaa ggg aat aag ggc gac acg gaa atg ttg aat 38467 Lys Cys Arg Lys Lys Gly Asn Lys Gly Asp Thr Glu Met Leu Asn 7255 7260 7265 act cat act cttccttttt caatattatt gaagcattta tcagggttat 38516 Thr His Thr 7270 tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg 38576 cgcacatttc cccgaaaagt gccacctgac gtctaagaaa ccattattat catgacatta 38636 acctataaaa ataggcgtat cacgaggccc tttcgtcttc aagaattgtt taaactacca 38696 tcat 38700 <210> 337 <211> 363 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 337 Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 1 5 10 15 Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 20 25 30 His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 35 40 45 Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 50 55 60 Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 65 70 75 80 Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 85 90 95 Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 100 105 110 Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val 115 120 125 Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 130 135 140 Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 145 150 155 160 Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 165 170 175 Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 180 185 190 Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 195 200 205 Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 210 215 220 Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 225 230 235 240 Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 245 250 255 Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 260 265 270 Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 275 280 285 Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 290 295 300 Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 305 310 315 320 Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 325 330 335 Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 340 345 350 Val Gly Gly Pro Gly His Lys Ala Arg Val Leu 355 360 <210> 338 <211> 394 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 338 Met His Pro Val Leu Arg Gln Met Arg Pro His His Pro Pro Pro Gln 1 5 10 15 Gln Gln Pro Pro Pro Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln 20 25 30 Gln Gln Leu Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala Gly 35 40 45 Gln Thr Ser Gln Tyr Asp Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala 50 55 60 Arg Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys 65 70 75 80 Arg Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp 85 90 95 Arg Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ala Arg Phe His Ala 100 105 110 Gly Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp 115 120 125 Glu Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala 130 135 140 His Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys 145 150 155 160 Glu Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu 165 170 175 Ile Ala Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu 180 185 190 Leu Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln 195 200 205 Leu Phe Leu Val Val Gln His Ser Arg Asp Asn Glu Ala Phe Arg Glu 210 215 220 Ala Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu 225 230 235 240 Val Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu 245 250 255 Ser Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys 260 265 270 Tyr Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys 275 280 285 Glu Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu 290 295 300 Thr Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg 305 310 315 320 Ala Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met 325 330 335 His Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser 340 345 350 Tyr Phe Asp Met Gly Ala Asp Leu His Trp Gln Pro Ser Arg Arg Ala 355 360 365 Leu Glu Ala Ala Gly Gly Pro Pro Tyr Ile Glu Glu Val Asp Asp Glu 370 375 380 Val Asp Glu Glu Gly Glu Tyr Leu Glu Asp 385 390 <210> 339 <211> 589 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 339 Met Gln Gln Gln Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu Gln 1 5 10 15 Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala Met 20 25 30 Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg Gln 35 40 45 Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val Pro 50 55 60 Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn Ala 65 70 75 80 Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val Tyr 85 90 95 Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val Gln 100 105 110 Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ala Gln 115 120 125 Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala Leu 130 135 140 Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln Glu 145 150 155 160 Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Thr Glu Val 165 170 175 Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr 180 185 190 Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys Asn 195 200 205 Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala Thr 210 215 220 Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu Val 225 230 235 240 Ala Pro Phe Thr Asp Ser Gly Ser Ile Asn Arg Asn Ser Tyr Leu Gly 245 250 255 Tyr Leu Ile Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp 260 265 270 Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly Gln 275 280 285 Asp Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr Asn 290 295 300 Arg Ser Gln Lys Ile Pro Pro Gln Tyr Thr Leu Ser Ala Glu Glu Glu 305 310 315 320 Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met Gln 325 330 335 Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn Met 340 345 350 Glu Pro Ser Met Tyr Ala Ser Asn Arg Pro Phe Ile Asn Lys Leu Met 355 360 365 Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr Asn 370 375 380 Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr Gly 385 390 395 400 Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp Val 405 410 415 Asp Ser Ser Val Phe Ser Pro Arg Pro Gly Ala Asn Glu Arg Pro Leu 420 425 430 Trp Lys Lys Glu Gly Ser Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly 435 440 445 Arg Glu Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro 450 455 460 Ser Leu Pro Phe Ser Leu Asn Ser Ile Arg Ser Ser Glu Leu Gly Arg 465 470 475 480 Ile Thr Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser 485 490 495 Leu Leu Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu 500 505 510 Ser Leu Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala Gln Glu His 515 520 525 Arg Asp Asp Pro Ser Gln Gly Ala Thr Ser Arg Gly Ser Ala Ala Arg 530 535 540 Lys Arg Arg Trp His Asp Arg Gln Arg Gly Leu Met Trp Asp Asp Glu 545 550 555 560 Asp Ser Ala Asp Asp Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Asn 565 570 575 Pro Phe Ala His Leu Arg Pro Arg Ile Gly Arg Met Met 580 585 <210> 340 <211> 532 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 340 Met Met Arg Arg Ala Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Met Ala Ala Ala Ala Ala Met Gln Pro Pro Leu 20 25 30 Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg 35 40 45 Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg 50 55 60 Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr 65 70 75 80 Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp 85 90 95 Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg 100 105 110 Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro 115 120 125 Asn Val Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met 130 135 140 Val Ser Arg Lys Thr Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln 145 150 155 160 Asp Ile Leu Glu Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn 165 170 175 Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp 180 185 190 Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile 195 200 205 Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val 210 215 220 Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro 225 230 235 240 Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg 245 250 255 Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly 260 265 270 Phe Gln Ile Met Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu 275 280 285 Leu Asp Val Asp Ala Tyr Glu Lys Ser Lys Glu Glu Ser Ala Ala Ala 290 295 300 Ala Thr Ala Ala Val Ala Thr Ala Ser Thr Glu Val Arg Gly Asp Asn 305 310 315 320 Phe Ala Ser Pro Ala Ala Val Ala Ala Ala Glu Ala Ala Glu Thr Glu 325 330 335 Ser Lys Ile Val Ile Gln Pro Val Glu Lys Asp Ser Lys Asp Arg Ser 340 345 350 Tyr Asn Val Leu Pro Asp Lys Ile Asn Thr Ala Tyr Arg Ser Trp Tyr 355 360 365 Leu Ala Tyr Asn Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr 370 375 380 Leu Leu Thr Thr Ser Asp Val Thr Cys Gly Val Glu Gln Val Tyr Trp 385 390 395 400 Ser Leu Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg 405 410 415 Gln Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val Tyr 420 425 430 Ser Lys Ser Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg 435 440 445 Ala Phe Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln 450 455 460 Ile Leu Val Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn 465 470 475 480 Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile 485 490 495 Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys 500 505 510 Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val Ala Pro Arg Val Leu Ser 515 520 525 Ser Arg Thr Phe 530 <210> 341 <211> 193 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 341 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Val Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ala 130 135 140 Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala Ala 145 150 155 160 Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val Arg 165 170 175 Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro Arg 180 185 190 Thr <210> 342 <211> 342 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 342 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Val Val Lys Glu Glu Arg Lys Pro Arg Lys 20 25 30 Ile Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Glu Ser Asp Val Asp 35 40 45 Gly Leu Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln 50 55 60 Trp Arg Gly Arg Lys Val Arg Pro Val Leu Arg Pro Gly Thr Thr Val 65 70 75 80 Val Phe Thr Pro Gly Glu Arg Ser Gly Thr Ala Ser Lys Arg Ser Tyr 85 90 95 Asp Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Ala Glu Arg 100 105 110 Leu Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Ser Ala Pro Lys Glu 115 120 125 Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu 130 135 140 Lys Pro Val Thr Leu Gln Gln Val Leu Pro Thr Ala Ala Pro Arg Arg 145 150 155 160 Gly Phe Lys Arg Glu Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met 165 170 175 Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu Thr Met Lys Val 180 185 190 Asp Pro Asp Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln Val 195 200 205 Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr Glu 210 215 220 Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr Met 225 230 235 240 Glu Val Gln Thr Asp Pro Trp Met Pro Ser Ala Thr Ser Arg Arg Pro 245 250 255 Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn Tyr Ala Leu 260 265 270 His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg Phe Tyr 275 280 285 Arg Gly His Thr Ser Arg Arg Arg Lys Thr Thr Thr Arg Arg Arg Arg 290 295 300 Arg Arg Thr Thr Ala Ala Ala Ser Thr Pro Ala Ala Leu Val Arg Arg 305 310 315 320 Val Tyr Arg Arg Gly Arg Ala Pro Leu Thr Leu Pro Arg Ala Arg Tyr 325 330 335 His Pro Ser Ile Ala Ile 340 <210> 343 <211> 77 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 343 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Ala Gly Asn Gly Met Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 344 <211> 259 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 344 Met Asp Ser Asp Ala Pro Gly Pro Val Met Cys Phe Arg Arg Gln Met 1 5 10 15 Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg Pro 20 25 30 Phe Met Gly Thr Trp Ser Asp Ile Gly Thr Ser Gln Leu Asn Gly Gly 35 40 45 Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser 50 55 60 Thr Leu Lys Thr Tyr Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly Gln 65 70 75 80 Ala Leu Arg Asp Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val Val 85 90 95 Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn Gln 100 105 110 Ala Val Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro Ala 115 120 125 Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu Asp 130 135 140 Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu Leu 145 150 155 160 Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu Gly 165 170 175 Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu Lys 180 185 190 Pro Glu Ser Ser Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Gln Pro 195 200 205 Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val Ala 210 215 220 Arg Ala Arg Pro Gly Gly Thr Ala Arg Pro His Ala Asn Trp Gln Ser 225 230 235 240 Thr Leu Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg Arg 245 250 255 Arg Cys Tyr <210> 345 <211> 931 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 345 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Thr Cys Gln Trp Thr Tyr Thr Asp Lys Gln Thr Glu Lys 130 135 140 Thr Ala Thr Tyr Gly Asn Ala Pro Val Gln Gly Ile Ala Ile Thr Lys 145 150 155 160 Asp Gly Ile Gln Leu Gly Thr Asp Ser Asp Gly Asn Pro Val Tyr Ala 165 170 175 Gln Lys Thr Phe Glu Pro Glu Pro Gln Val Gly Asp Ala Glu Trp His 180 185 190 Asp Thr Thr Gly Thr Asp Glu Lys Tyr Gly Gly Arg Ala Leu Lys Pro 195 200 205 Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys Pro Thr Asn 210 215 220 Lys Glu Gly Gly Gln Ala Lys Asn Arg Thr Lys Thr Asp Gly Thr Gly 225 230 235 240 Glu Glu Pro Asp Ile Asp Met Ala Phe Phe Asp Gly Arg Asn Ala Thr 245 250 255 Thr Ala Gly Leu Ala Pro Glu Ile Val Leu Tyr Thr Glu Asn Val Asp 260 265 270 Leu Glu Thr Pro Asp Thr His Ile Val Tyr Lys Ala Gly Thr Asp Asp 275 280 285 Ser Ser Ser Ser Ile Asn Leu Gly Gln Gln Ser Met Pro Asn Arg Pro 290 295 300 Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn 305 310 315 320 Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn 325 330 335 Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu 340 345 350 Leu Leu Asp Ser Leu Gly Asp Arg Thr Leu Tyr Phe Ser Met Trp Asn 355 360 365 Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His 370 375 380 Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asp Ala Val 385 390 395 400 Gly Arg Thr Asp Thr Tyr Gln Gly Ile Lys Pro Asn Gly Gly Asp Pro 405 410 415 Ala Thr Trp Ala Lys Asp Asp Ser Ala Asn Asp Ala Asn Glu Met Gly 420 425 430 Lys Gly Asn Pro Phe Ala Met Glu Ile Asn Ile Gln Ala Asn Leu Trp 435 440 445 Arg Asn Phe Leu Tyr Ala Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr 450 455 460 Lys Tyr Thr Pro Ala Asn Val Thr Leu Pro Thr Asn Thr Asn Thr Tyr 465 470 475 480 Asp Tyr Met Asn Gly Arg Val Val Ala Pro Ser Leu Val Asp Ser Tyr 485 490 495 Ile Asn Ile Gly Ala Arg Trp Ser Leu Asp Pro Met Asp Asn Val Asn 500 505 510 Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu 515 520 525 Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro Gln Lys 530 535 540 Phe Phe Ala Ile Lys Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr 545 550 555 560 Glu Trp Asn Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu 565 570 575 Gly Asn Asp Leu Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile 580 585 590 Asn Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr 595 600 605 Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp 610 615 620 Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr 625 630 635 640 Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly 645 650 655 Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser 660 665 670 Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp 675 680 685 Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe 690 695 700 Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn 705 710 715 720 Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn Val Ala 725 730 735 Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala His 740 745 750 Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys Asp 755 760 765 Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val 770 775 780 Val Asp Glu Val Asn Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr 785 790 795 800 Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg 805 810 815 Gln Gly Gln Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys 820 825 830 Ser Ala Val Thr Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val 835 840 845 Met Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu 850 855 860 Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu 865 870 875 880 Asp Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr 885 890 895 Val Val Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro His Arg 900 905 910 Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn 915 920 925 Ala Thr Thr 930 <210> 346 <211> 210 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 346 Met Met Ala Glu Ala Ala Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile 1 5 10 15 Ile Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys 20 25 30 Arg Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val 35 40 45 Asn Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala 50 55 60 Trp Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe 65 70 75 80 Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu 85 90 95 Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu 100 105 110 Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu 115 120 125 Phe Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro 130 135 140 Met Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly 145 150 155 160 Met Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu 165 170 175 Ala Leu Tyr Arg Phe Leu Asn Ser His Ser Ala Tyr Phe Arg Ser His 180 185 190 Arg Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Asn Gln 195 200 205 Asp Met 210 <210> 347 <211> 503 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 347 Glu Ile Glu Arg Val Leu Pro Gly Leu Gly Met Ala Arg Gly Gln Gly 1 5 10 15 His Val Ala Glu Leu Val Leu Gly Gln Pro Leu Glu Leu Gly Asp Gln 20 25 30 Gln Phe Arg Gln Arg Gly Val Gly Glu Gly Val Gly Pro Gln Leu Pro 35 40 45 Arg Gln Leu Gln Gly Ala Gln Gln Val Gly Arg Gly Asp Leu Glu Ile 50 55 60 Ala Val Gly Thr Arg Val Leu Arg Ala Arg Val Ala Val His Gly Val 65 70 75 80 Ala Ala Leu Glu His His Gln Gly Arg Val Leu His Ala Arg Gln His 85 90 95 Arg Arg Val Gly Asp Ala Leu His Val Glu Val Leu Gly Val Gly His 100 105 110 Pro Glu Gly Gly His Leu Ala Gly Leu Pro Ser His Ser Gly His Ala 115 120 125 Pro Gly Leu Val Val Ala Ile Ala Val Gln Gly Asp Gln His His Leu 130 135 140 Gly Leu Val Gly Val His Pro Arg Val His Gly Leu His Glu Ser Leu 145 150 155 160 Gln Leu Pro Glu Ser Leu Leu Gly Leu Gly Ser Leu Gly Glu Glu Asp 165 170 175 Pro Ala Gly Leu Ala Arg Glu Leu Val Gly Ser Ala Pro Gly Val Val 180 185 190 His Ala Ala Ala Arg Val Val Val Gly Gln Leu His His Ala Ala Pro 195 200 205 Pro Ala Val Leu Gly Asp Leu Gly Pro Val Gly Val Leu Leu Gln Arg 210 215 220 Ala Leu Pro Val Leu Ala Arg His Ile His Leu Asp His Val Leu Leu 225 230 235 240 Leu Asp His Gly Gly Pro Val Gln Ala Pro Gln Leu Ala Leu Gly Leu 245 250 255 Gly Ala Pro Val Gln Pro Gln Arg Ala Pro Gly Ala Leu Pro Val Leu 260 265 270 Val Gly Asp Leu Gly Met Arg Val His Glu Pro Leu Gln Glu Ala Ala 275 280 285 His His Gly Gly Gln Gly Leu Val Ala Ser Glu Gly Gln Arg Asp Ala 290 295 300 Ala Val Leu Leu Val Asp Val Gln Val Ala Asp Ala Ala Val His Leu 305 310 315 320 Ala Leu Leu Gly His Gln Leu Glu Val Gly Phe Gln Val Gly Leu His 325 330 335 Ala Val Ala Val His Gln Tyr Ser His Asp Phe His Thr Leu Leu Pro 340 345 350 Gly Arg Asp Asp Gly Gln Ala His Arg Val Leu His His His Leu Ser 355 360 365 Thr Ser Ser Arg Gly Gln Gly Val Ala Leu Ile Gln Gly Leu Lys Ala 370 375 380 Pro Leu Ala Val Leu Leu Gly Asp Pro His Arg Gly Val Ala Glu Ala 385 390 395 400 His Gly Arg Gln Leu Leu Leu Gly Leu Pro Phe Val Leu Ala Val Leu 405 410 415 Ala Asp Val Leu Gln Asp His Met Leu Gly Leu Ala Gly Phe Leu Leu 420 425 430 Gly Arg Gln Arg Arg Arg Arg Cys Leu Trp Arg Gly Gly Ala Arg Val 435 440 445 Leu Ala His His Tyr Tyr Leu Phe Leu Phe Val Val Arg Gly His Ala 450 455 460 Ala Val Gly Met Ser Leu Arg Gly Gln Arg Arg Arg Arg Arg Ala Leu 465 470 475 480 Ala Ala Ala Thr Trp Arg Met Ala Gly Arg Ala Pro Ser Ala Ile Gly 485 490 495 Gly Ala Leu Pro Ala Ala Leu 500 <210> 348 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 348 Leu Thr Ser Ser Ala Ala Gly His 1 5 <210> 349 <211> 184 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 349 Met Pro Arg Gly Asn Lys Lys Leu Lys Val Glu Leu Pro Pro Val Glu 1 5 10 15 Asp Leu Glu Glu Asp Trp Glu Asn Ser Ser Gln Ala Glu Glu Glu Met 20 25 30 Glu Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp 35 40 45 Ser Leu Glu Glu Asp Glu Glu Glu Ala Glu Val Glu Glu Ala Ala Ala 50 55 60 Ala Arg Pro Ser Ser Ser Ala Gly Glu Lys Ala Ser Ser Thr Asp Thr 65 70 75 80 Ile Ser Ala Pro Gly Arg Gly Pro Ala Arg Pro His Ser Arg Trp Asp 85 90 95 Glu Thr Gly Arg Phe Pro Asn Pro Thr Ile Gln Thr Gly Lys Lys Glu 100 105 110 Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val Ser 115 120 125 Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr Leu 130 135 140 Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr Tyr 145 150 155 160 Arg His Leu His Ser Pro Tyr Tyr Phe Gln Glu Glu Ala Ala Ala Glu 165 170 175 Lys Asp Gln Gln Lys Thr Ser Ser 180 <210> 350 <211> 227 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 350 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Leu Thr Ala Thr 50 55 60 Pro Arg Asn His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Thr Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Ile Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 351 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 351 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Thr 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Val Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Gln Gln Gly Asn Thr Leu Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asp His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 352 <211> 176 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 352 Met Gly Lys Ile Thr Leu Val Cys Gly Val Leu Val Thr Val Val Leu 1 5 10 15 Ser Ile Leu Gly Gly Gly Ser Ala Ala Val Val Thr Glu Lys Lys Ala 20 25 30 Asp Pro Cys Leu Thr Phe Asn Pro Asp Lys Cys Arg Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Thr Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Ser Val Ala Ile Gln Tyr Lys Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Thr Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Leu His Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Glu His Met Cys Glu Thr Ala Met Phe Met Ser Lys Gln Tyr Gly Met 115 120 125 Trp Pro Pro Arg Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Ala Cys Thr Val Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 353 <211> 247 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 353 Met Arg Leu Leu Ile Phe Val Ile Ile Thr Leu Ser Phe Asn Tyr Ala 1 5 10 15 His Gly Tyr Ala Asn Ile Gln Lys Thr Leu Tyr Val Gly Ser Asp Ser 20 25 30 Thr Leu Glu Gly Thr Gln Ser Gln Ala Arg Val Ser Trp Tyr Phe Tyr 35 40 45 Lys Gly Ser Asp Asp Pro Ile Thr Leu Cys Lys Gly Asp Gln Gly Arg 50 55 60 Ile Thr Lys Pro Pro Ile Thr Phe Ser Cys Thr Arg Thr Asn Leu Thr 65 70 75 80 Leu Leu Ser Ile Thr Lys Glu Tyr Ala Gly Thr Tyr Tyr Ser Thr Asn 85 90 95 Phe His Arg Gly Gln Asp Lys Tyr Tyr Thr Val Lys Val Glu Asn Pro 100 105 110 Thr Thr Pro Arg Thr Thr Thr Lys Pro Thr Thr Thr Lys Lys Pro Thr 115 120 125 Thr Pro Lys Lys Pro Thr Thr Pro Lys Thr Thr Lys Thr Thr Thr Ala 130 135 140 Lys Thr Thr Thr Thr Lys Pro Thr Thr Thr Ser Thr Thr Leu Ala Ile 145 150 155 160 Thr Thr His Thr His Thr Glu Leu Thr Ser Gln Ala Thr Thr Glu Asn 165 170 175 Asp Leu Val Ala Leu Leu Gln Lys Gly Glu Asn Ser Ser Ser Ser Pro 180 185 190 Leu Pro Thr Thr Pro Ser Glu Glu Ile Pro Lys Ser Met Val Gly Ile 195 200 205 Ile Ala Ala Val Val Val Cys Met Leu Ile Ile Ile Leu Cys Met Met 210 215 220 Tyr Tyr Ala Cys Tyr Tyr Arg Lys His Arg Leu Asn Asn Lys Leu Asp 225 230 235 240 Pro Leu Leu Ser Val Asp Phe 245 <210> 354 <211> 208 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 354 Met Lys Ile Leu Ser Leu Phe Val Phe Ser Ile Ile Ile Thr Ser Ala 1 5 10 15 Ile Cys Glu Ser Val Asp Lys Asp Val Thr Val Thr Thr Gly Ser Asn 20 25 30 Tyr Thr Leu Lys Gly Pro Ser Ser Gly Met Leu Ser Trp Tyr Cys Tyr 35 40 45 Phe Gly Asn Asp Asp Lys Gln Thr Glu Leu Cys Asn Phe Gln Asn Gly 50 55 60 Lys Thr Lys Asn Ser Lys Ile Asp Asn Tyr Gln Cys Gln Gly Thr Asn 65 70 75 80 Leu Val Leu Met Asn Ile Thr Lys Ala Tyr Ala Gly Ser Tyr Ser Cys 85 90 95 Pro Gly Gln Asn Thr Glu Glu Met Ile Phe Tyr Lys Leu Ile Val Val 100 105 110 Asp Pro Thr Thr Pro Ala Pro Pro Thr Thr Thr Lys Ala His Thr Thr 115 120 125 Asp Thr Gln Glu Thr Thr Pro Glu Ala Glu Val Ala Glu Leu Ala Lys 130 135 140 Gln Ile His Glu Asp Ser Phe Val Ala Asn Thr Pro Thr His Pro Gly 145 150 155 160 Pro Gln Cys Pro Gly Pro Leu Val Ser Gly Ile Val Gly Val Leu Cys 165 170 175 Gly Leu Ala Val Ile Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr 180 185 190 Arg Arg Leu His Arg Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 195 200 205 <210> 355 <211> 291 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 355 Met Lys Ala Leu Ser Thr Leu Val Phe Leu Ser Leu Ile Gly Ile Val 1 5 10 15 Phe Ser Ala Gly Phe Leu Lys Asn Leu Thr Ile Ile Glu Gly Asp Asn 20 25 30 Ala Thr Leu Val Gly Ile Ser Gly Gln Asn Val Ser Trp Leu Lys Tyr 35 40 45 His Leu Asp Gly Trp Lys Pro Ile Cys Thr Trp Asn Val Ser Val Tyr 50 55 60 Thr Cys His Gly Val Asn Leu Thr Ile Thr Asn Ala Thr Gln Asp Gln 65 70 75 80 Asn Gly Arg Phe Lys Gly Gln Ser Phe Thr Ser Asn Asn Gly Tyr Glu 85 90 95 Thr His Asn Met Phe Ile Tyr Asp Val Thr Val Ile Ser Asn Lys Thr 100 105 110 Thr Pro Thr Thr Gln Thr Pro Thr Thr His Ser Ser Thr His Ala Met 115 120 125 Gln Thr Thr Gln Thr Thr Thr Tyr Thr Thr Ser Thr Glu Ser Thr Thr 130 135 140 Thr Thr Thr Ala Glu Val Ser Ser Thr Ala Pro Gln Pro Gln Ala Leu 145 150 155 160 Ala Leu Met Ala Gln Pro Ser Ser Met Thr Ala Lys Thr Asn Glu Gln 165 170 175 Thr Thr Glu Phe Leu Ser Thr Ile Gln Ser Ser Thr Thr Ala Thr Ser 180 185 190 Ser Ala Phe Ser Ser Thr Ala Asn Leu Thr Ser Leu Ser Ser Thr Pro 195 200 205 Ile Ser Asn Ala Thr Thr Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys 210 215 220 Gln Ser Glu Ser Ser Thr Gln Leu Gln Ile Thr Leu Leu Ile Val Ile 225 230 235 240 Gly Val Val Ile Leu Ala Val Leu Leu Tyr Phe Ile Phe Cys Arg Arg 245 250 255 Ile Pro Asn Ala Lys Pro Ala Tyr Lys Pro Ile Val Ile Gly Thr Pro 260 265 270 Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser Phe 275 280 285 Thr Val Trp 290 <210> 356 <211> 134 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 356 Met Thr Asp Pro Met Ala Asn Asn Thr Val Asn Asp Leu Leu Asp Met 1 5 10 15 Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg Gln 20 25 30 Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Ala Val Ala Ile His 35 40 45 Gln Cys Lys Arg Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile Ser 50 55 60 Phe Glu Val Thr Ser Thr Asp His Arg Leu Ser Tyr Glu Leu Leu Gln 65 70 75 80 Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val Ile 85 90 95 Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys Asp 100 105 110 Ser Pro Glu Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu Arg 115 120 125 Asp Leu Leu Pro Met Asn 130 <210> 357 <211> 490 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 357 Met Phe Ser Val Ser Ser Thr Ser Leu Pro Ser Ser Gln Leu Trp Tyr 1 5 10 15 Cys Arg Pro Arg Arg Ala Ala Asn Phe Leu His Thr Leu Lys Gly Met 20 25 30 Ser Asn Ser Ser Cys Pro Ser Ile Phe Ile Phe Ile Phe Tyr Gln Met 35 40 45 Ser Lys Lys Arg Ala Arg Val Asp Asp Gly Phe Asp Pro Val Tyr Pro 50 55 60 Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro Phe 65 70 75 80 Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser Leu 85 90 95 Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Ala Val Thr Leu Lys 100 105 110 Leu Gly Glu Gly Val Asp Leu Asp Asp Ser Gly Lys Leu Ile Ser Lys 115 120 125 Asn Ala Thr Lys Ala Thr Ala Pro Leu Ser Ile Ser Asn Gly Thr Ile 130 135 140 Ser Leu Asn Met Ala Ala Pro Phe Tyr Asn Asn Asn Gly Thr Leu Ser 145 150 155 160 Leu Asn Val Ser Thr Pro Leu Ala Val Phe Pro Thr Phe Asn Thr Leu 165 170 175 Gly Ile Ser Leu Gly Asn Gly Leu Gln Thr Ser Asn Lys Leu Leu Thr 180 185 190 Val Gln Leu Thr His Pro Leu Thr Phe Ser Ser Asn Ser Ile Thr Val 195 200 205 Lys Thr Asp Lys Gly Leu Tyr Ile Asn Ser Ser Gly Asn Arg Gly Leu 210 215 220 Glu Ala Asn Ile Ser Leu Lys Arg Gly Leu Ile Phe Asp Gly Asn Ala 225 230 235 240 Ile Ala Thr Tyr Leu Gly Ser Gly Leu Asp Tyr Gly Ser Tyr Asp Ser 245 250 255 Asp Gly Lys Thr Arg Pro Ile Ile Thr Lys Ile Gly Ala Gly Leu Asn 260 265 270 Phe Asp Ala Asn Asn Ala Met Ala Val Lys Leu Gly Thr Gly Leu Ser 275 280 285 Phe Asp Ser Ala Gly Ala Leu Thr Ala Gly Asn Lys Glu Asp Asp Lys 290 295 300 Leu Thr Leu Trp Thr Thr Pro Asp Pro Ser Pro Asn Cys Gln Leu Leu 305 310 315 320 Ser Asp Arg Asp Ala Lys Phe Thr Leu Cys Leu Thr Lys Cys Gly Ser 325 330 335 Gln Ile Leu Gly Thr Val Ala Val Ala Ala Val Thr Val Gly Ser Ala 340 345 350 Leu Asn Pro Ile Asn Asp Thr Val Lys Ser Ala Ile Val Phe Leu Arg 355 360 365 Phe Asp Ser Asp Gly Val Leu Met Ser Asn Ser Ser Met Val Gly Asp 370 375 380 Tyr Trp Asn Phe Arg Glu Gly Gln Thr Thr Gln Ser Val Ala Tyr Thr 385 390 395 400 Asn Ala Val Gly Phe Met Pro Asn Leu Gly Ala Tyr Pro Lys Thr Gln 405 410 415 Ser Lys Thr Pro Lys Asn Ser Ile Val Ser Gln Val Tyr Leu Asn Gly 420 425 430 Glu Thr Thr Met Pro Met Thr Leu Thr Ile Thr Phe Asn Gly Thr Asp 435 440 445 Glu Lys Asp Thr Thr Pro Val Ser Thr Tyr Ser Met Thr Phe Thr Trp 450 455 460 Gln Trp Thr Gly Asp Tyr Lys Asp Lys Asn Ile Thr Phe Ala Thr Asn 465 470 475 480 Ser Phe Thr Phe Ser Tyr Met Ala Gln Glu 485 490 <210> 358 <211> 186 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 358 Ser Gly Arg Arg Ala Val Arg Val Ile Ile Arg Glu Arg Asp Arg Ala 1 5 10 15 Val Val Ala His Gln Ala Pro Gln Gln Ser Leu Ser Ala Pro Leu Arg 20 25 30 Gln Ala Ala Ala Gln Gly Val Trp Val Gln Gly Leu Pro Ala His Asp 35 40 45 Ala Asp Gly Pro Glu His Gln Ser Pro Gly Ala Ala Gly Ala Ala Ala 50 55 60 Asp Ala Asp Leu Thr Gln Val Gly Ala Val Arg Ala Ala Gln His Tyr 65 70 75 80 Gln Val Val Gln Gln Ser Ile Val Gln Arg Ala Pro Ala Lys Thr His 85 90 95 Leu Trp Asn Tyr Ala Ala His Met Ser Ile Val Pro Asp Pro Asp Val 100 105 110 Asn Gln Val Ala Pro Pro Pro Glu His Thr Ala His Val His Asp Leu 115 120 125 Leu Gly His Val Gln Val His His Leu Pro Val Pro His His Pro Leu 130 135 140 Val Glu His Ala Ala Leu Asp Asn Pro Ala Glu Pro Asp Gly Gln His 145 150 155 160 Arg Pro Ala Arg His Ala Ala Gln Gly Pro Arg Val Leu Ala Met Ala 165 170 175 Val Glu His Pro Pro Leu Thr Ala Val Asp 180 185 <210> 359 <211> 83 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 359 Leu Gly Ala Glu Gln Val Tyr Val Gly Thr Ala Gln Ala His Ala His 1 5 10 15 Ala Cys Leu Gln His Ser Gln Phe Leu Gly Gly Gln Asp His Val Pro 20 25 30 Gly His Gly Glu Leu Leu Gln Asp Ser Glu Pro Gly Arg Thr Gly Gln 35 40 45 Pro Ser His Thr Thr Tyr Ile Val His Gly Gln Gly Ile Ala Ile Arg 50 55 60 Gln His Arg Met Ile Leu His Gln Arg Ser Ala Gly Leu Gly Leu Leu 65 70 75 80 Thr Ala Arg <210> 360 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 360 Gly Gly Arg Arg Leu Val Arg Met Met Ala Gly 1 5 10 <210> 361 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 361 Ser Cys Ser Gly Ser Cys His Asp Gly Ala Val Ser 1 5 10 <210> 362 <211> 63 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 362 Phe Gln Thr Val Ser Glu His Phe Lys Met Gln Val Pro Glu Val Ala 1 5 10 15 Pro Leu Ala Pro Thr Val Leu Val Glu Asn Asn Ser Gln Val Lys Gly 20 25 30 Asp Thr Val Leu Glu Met Phe His Gly Gly Phe Gln Gln Ser Leu His 35 40 45 Ala His Ile Gln Lys Gln Glu Asp Ser Glu Ser Gly Ser Val Phe 50 55 60 <210> 363 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 363 Phe Leu Asn His His Ile Thr Leu Leu His His Pro Gln Ile Ile Phe 1 5 10 15 Ile Phe Pro Ala Leu Asn Asp Ser Tyr 20 25 <210> 364 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 364 Ile Gln Ala Ser His Asp Lys Lys Leu Ala Gln Ser Ala Leu His Arg 1 5 10 15 His Ser <210> 365 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 365 Ala His Pro His 1 <210> 366 <211> 63 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 366 Asn His Ala Ser Leu Ala Asn Arg Trp Val Asn His Ser Phe Gln His 1 5 10 15 Gln Ala Gly Tyr Gly Val Ser Gly Ala Thr Leu Val Glu Ala Val Ala 20 25 30 Met Ile Glu Lys His His Arg Glu Thr Phe Pro Val Ala Gly Met Asp 35 40 45 Asp Ser Arg Arg Ser Ile His Ser Gly Asn Ile Gly Ile Arg Glu 50 55 60 <210> 367 <211> 60 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 367 Lys Lys Ala Thr Tyr Lys Ala Ser Gly His Tyr Asn Ala Gln Ser Gln 1 5 10 15 Phe Gln Gln Ser His Pro Met Arg Met Glu His Lys Ile Gly Arg Cys 20 25 30 Val Lys Asn Val Ile Thr Pro Leu Leu His Arg Gln Gln Ser Pro Arg 35 40 45 Ser Leu Gln Lys His Ile Gln Ser Leu Ser Val His 50 55 60 <210> 368 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 368 Leu Pro Met Leu Asn Gln 1 5 <210> 369 <211> 75 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 369 Gly Thr Tyr Leu Ser Asp Leu Ser Ile Ser Phe Ile His Ser Cys Leu 1 5 10 15 Thr Pro Arg Arg Val Asp Asn Tyr Asp Thr Gly Gly Leu Thr Ile Trp 20 25 30 Pro Gln Cys Cys Asn Asp Thr Ala Arg Pro Thr Leu Thr Gly Ser Arg 35 40 45 Phe Ile Ser Asn Lys Pro Ala Ser Arg Lys Gly Arg Ala Gln Lys Trp 50 55 60 Ser Cys Asn Phe Ile Arg Leu His Pro Val Tyr 65 70 75 <210> 370 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 370 Leu Leu Pro Gly Ser 1 5 <210> 371 <211> 44 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 371 Phe Ala Gln Arg Cys Cys His Cys Cys Arg His Arg Gly Val Thr Leu 1 5 10 15 Val Val Trp Tyr Gly Phe Ile Gln Leu Arg Phe Pro Thr Ile Lys Ala 20 25 30 Ser Tyr Met Ile Pro His Val Val Gln Lys Ser Gly 35 40 <210> 372 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 372 Leu Leu Arg Ser Ser Asp Arg Cys Gln Lys 1 5 10 <210> 373 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 373 Val Gly Arg Ser Val Ile Thr His Gly Tyr Gly Ser Thr Ala 1 5 10 <210> 374 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 374 Phe Ser Tyr Cys His Ala Ile Arg Lys Met Leu Phe Cys Asp Trp 1 5 10 15 <210> 375 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 375 Val Leu Asn Gln Val Ile Leu Arg Ile Val Tyr Ala Ala Thr Glu Leu 1 5 10 15 Leu Leu Pro Gly Val Asn Thr Gly 20 <210> 376 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 376 Tyr Arg Ala Thr 1 <210> 377 <211> 74 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 377 Gln Asn Phe Lys Ser Ala His His Trp Lys Thr Phe Phe Gly Ala Lys 1 5 10 15 Thr Leu Lys Asp Leu Thr Ala Val Glu Ile Gln Phe Asp Val Thr His 20 25 30 Ser Cys Thr Gln Leu Ile Phe Ser Ile Phe Tyr Phe His Gln Arg Phe 35 40 45 Trp Val Ser Lys Asn Arg Lys Ala Lys Cys Arg Lys Lys Gly Asn Lys 50 55 60 Gly Asp Thr Glu Met Leu Asn Thr His Thr 65 70 <210> 378 <211> 38700 <212> DNA <213> Artificial Sequence <220> <223> p2878 - E1 deleted molecular clone with HIVgagshort insertion, based on Simian Adenovirus A1337 <220> <221> CDS <222> (15774)..(17369) <223> Penton <220> <221> CDS <222> (23360)..(25762) <223> 100K <220> <221> CDS <222> (27342)..(27977) <223> E3\CR1-alpha <220> <221> CDS <222> (31089)..(31535) <223> E3\RID-beta <220> <221> CDS <222> (34662)..(35027) <223> orf4 complement (34662..35027) <220> <221> CDS <222> (35389)..(35775) <223> orf2 complement (35389..35775) <400> 378 caataatata cctcaaactt tttgtgcgcg ttaatatgca aatgaggcgt ttgaatttgg 60 gaagggagga aggtgattgg ccgagagaag ggcgaccgtt aggggcgggg cgagtgacgt 120 tttgatgacg tggccgcgag gaggagccag tttgcaagtt ctcgtgggaa aagtgacgtc 180 aaacgaggtg tggtttgaac acggaaatac tcaattttcc cgcgctctct gacaggaaat 240 gaggtgtttt tgggcggatg caagttaaaa cgggccattt tcgcgcgaaa actgaatgag 300 gaagtgaaaa tctgagtaat ttcgcgttta tggcagggag gagtatttgc cgagggccga 360 gtagactttg accgattacg tgggggtttc gattaccgtg tttttcacct aaatttccgc 420 gtacggtgtc aaagtccggt gtttttacat catttccccg aaaagtgcca cctgacgtaa 480 ctataacggt cctaaggtag cgaaagctca gatctcccga tcccctatgg tgcactctca 540 gtacaatctg ctctgatgcc gcatagttaa gccagtatct gctccctgct tgtgtgttgg 600 aggtcgctga gtagtgcgcg agcaaaattt aagctacaac aaggcaaggc ttgaccgaca 660 attgcatgaa gaatctgctt agggttaggc gttttgcgct gcttcgcgat gtacgggcca 720 gatatacgcg ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat 780 tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg 840 gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa 900 cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact 960 tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta 1020 aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt 1080 acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg 1140 ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg 1200 ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc 1260 cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt 1320 tagtgaaccg tcagatcgcc tggagacgcc atccacgctg ttttgacctc catagaagac 1380 accgggaccg atccagcctc cgcgggcgcg cgtcgacaga gagatgggtg cgagagcgtc 1440 agtattaagc gggggagaat tagatcgatg ggaaaaaatt cggttaaggc cagggggaaa 1500 gaagaagtac aagctaaagc acatcgtatg ggcaagcagg gagctagaac gattcgcagt 1560 taatcctggc ctgttagaaa catcagaagg ctgtagacaa atactgggac agctacaacc 1620 atcccttcag acaggatcag aggagcttcg atcactatac aacacagtag caaccctcta 1680 ttgtgtgcac cagcggatcg agatcaagga caccaaggaa gctttagaca agatagagga 1740 agagcaaaac aagtccaaga agaaggccca gcaggcagca gctgacacag gacacagcaa 1800 tcaggtcagc caaaattacc ctatagtgca gaacatccag gggcaaatgg tacatcaggc 1860 catatcacct agaactttaa atgcatgggt aaaagtagta gaagagaagg ctttcagccc 1920 agaagtgata cccatgtttt cagcattatc agaaggagcc accccacagg acctgaacac 1980 gatgttgaac accgtggggg gacatcaagc agccatgcaa atgttaaaag agaccatcaa 2040 tgaggaagct gcagaatggg atagagtgca tccagtgcat gcagggccta ttgcaccagg 2100 ccagatgaga gaaccaaggg gaagtgacat agcaggaact actagtaccc ttcaggaaca 2160 aataggatgg atgacaaata atccacctat cccagtagga gagatctaca agaggtggat 2220 aatcctggga ttgaacaaga tcgtgaggat gtatagccct accagcattc tggacataag 2280 acaaggacca aaagaaccct ttagagacta tgtagaccgg ttctataaaa ctctaagagc 2340 tgagcaagct tcacaggagg taaaaaattg gatgacagaa accttgttgg tccaaaatgc 2400 gaacccagat tgtaagacca tcctgaaggc tctcggccca gcggctacac tagaagaaat 2460 gatgacagca tgtcagggag taggaggacc cggccataag gcaagagttt tgtagggatc 2520 cactagttct agactcgagg gggggcccgg tacctttaag accaatgact tacaaggcag 2580 ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta attcactccc 2640 aaagaagaca agataaaccg ctgatcagcc tcgactgtgc cttctagttg ccagccatct 2700 gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc cactgtcctt 2760 tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc tattctgggg 2820 ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag gcatgctggg 2880 gatgcggtgg gctctatggc ttctgaggcg gaaagaacca gcagatctgc agatctgaat 2940 tcatctatgt cgggtgcgga gaaagaggta atgaaatggc acatatgctg gccaccgtgc 3000 atgtggcttc ccatgcccgc aagccctggc ccgagttcga gcacaatgtc atgaccaggt 3060 gcaatatgca tctggggtct cgccgaggca tgttcatgcc ctaccagtgc aacctgaatt 3120 atgtgaaggt gctgctggag cccgatgcca tgtccagagt gagcctgacg ggggtgtttg 3180 acatgaatgt ggaggtgtgg aagattctga gatatgatga atccaagacc aggtgccgag 3240 cctgcgagtg cggagggaag catgccaggt tccagcccgt gtgtgtggat gtgacggagg 3300 acctgcgacc cgatcatttg gtgttgtcct gcaccgggac ggagttcggt tccagcgggg 3360 aagaatctga ctagagtgag tagtgttctg gggcggggga ggacctgcat gagggccaga 3420 atgattgaaa tctgtgcttt tctgtgtgtt gcagcagcat gagcggaagc ggctcctttg 3480 agggaggggt attcagccct tatctgacgg ggcgtctccc ctcctgggcg ggagtgcgtc 3540 agaatgtgat gggatccacg gtggacggcc ggcccgtgca gcccgcgaac tcttcaaccc 3600 tgacctatgc aaccctgagc tcttcgtcgg tggacgcagc tgccgccgca gctgctgcat 3660 ctgccgccag cgccgtgcgc ggaatggcca tgggcgccgg ctactacggc actctggtgg 3720 ccaactcgag ttccaccaat aatcccgcca gcctgaacga ggagaagctg ctgctgctga 3780 tggcccagct cgaggccttg acccagcgcc tgggcgagct gacccagcag gtggctcagc 3840 tgcaggagca gacgcgggcc gcggttgcca cggtgaaatc caaataaaaa atgaatcaat 3900 aaataaacgg agacggttgt tgattttaac acagagtctg aatctttatt tgatttttcg 3960 cgcgcggtag gccctggacc accggtctcg atcattgagc actcggtgga tcttttccag 4020 gacccggtag aggtgggctt ggatgttgag gtacatgggc atgagcccgt cccgggggtg 4080 gaggtagctc cattgcaggg cctcgtgctc gggggtggtg ttgtaaatca cccagtcata 4140 gcaggggcgc agggcatggt gttgcacaat atctttgagg aggagactga tggccacggg 4200 cagccctttg gtgtaggtgt ttacaaatct gttgagctgg gagggatgca tgcgggggga 4260 gatgaggtgc atcttggcct ggatcttgag attggcgatg ttaccgccca gatcccgcct 4320 ggggttcatg ttgtgcagga ccaccagcac ggtgtatccg gtgcacttgg ggaatttatc 4380 atgcaacttg gaagggaagg cgtgaaagaa tttggcgacg cccttgtgcc cgcccaggtt 4440 ttccatgcac tcatccatga tgatggcgat ggggccgtgg gcggcggcct gggcaaaaac 4500 gtttcggggg tcggacacat catagttgtg gtcctgggtg agatcatcat aggccatttt 4560 aatgaatttg gggcggaggg tgccggactg ggggacaaag gtaccctcga tcccgggggc 4620 gtagttcccc tcacagatct gcatctccca ggctttgagc tcggaggggg ggatcatgtc 4680 cacctgcggg gcgataaaga acacggtttc cggggcggga gagatgagct gggccgaaag 4740 caagttccgg agcagctggg acttgccgca gccggtgggg ccgtagatga ccccgatgac 4800 cggttgcagg tggtagttga gggagagaca gctgccgtcc tcccggagga ggggggccac 4860 ctcgttcatc atctcgcgca cgtgcatgtt ctcgcgcacc agttccgcca ggaggcgctc 4920 tccccccagg gataggagct cctggagcga ggcgaagttt ttcagcggct tgagtccgtc 4980 ggccatgggc attttggaga gggtctgttg caagagttcc aagcggtccc agagctcggt 5040 gatgtgctct acggcatctc gatccagcag acctcctcgt ttcgcgggtt ggggcggctg 5100 cgggagtagg gcaccagacg atgggcgtcc agcgcagcca gggtccggtc cttccagggt 5160 cgcagcgtcc gcgtcagggt ggtctccgtc acggtgaagg ggtgcgcgcc gggctgggcg 5220 cttgcgaggg tgcgcttcag gctcatccgg ctggtcgaaa accgctcccg atcggcgccc 5280 tgcgcgtcgg ccaggtagca attgaccatg agttcgtaat tgagcgcctc ggccgcgtga 5340 cctttggcgc ggagcttacc tttggaagtc tgcccgcagg tgggacagag gagggacttg 5400 agggcgtaga gcttgggggc gaggaagacg gactcggggg cgtaggcgtc cgcgccgcag 5460 tgggcgcaga cggtctcgca ctccacgagc caggtgaggt cgggctggtc ggggtcaaaa 5520 accagtttcc cgccgttctt tttgatgcgt ttcttacctt tggtctccat gagctcgtgt 5580 ccccgctggg tgacaaagag gctgtccgtg tccccgtaga ccgactttat gggccggtcc 5640 tcgagcggtg tgccgcggtc ctcctcgtag aggaaccccg cccactccga gacgaaagcc 5700 cgggtccagg ccagcacgaa ggaggccacg tgggacgggt agcggtcgtt gtccaccagc 5760 gggtccacct tctccagggt atgcaaacac atgtccccct cgtccacatc caggaaggtg 5820 attggcttgt aagtgtaggc cacgtgaccg ggggtcccag ccgggggggt ataaaagggg 5880 gcgggcccct gctcgtcctc actgtcttcc ggatcgctgt ccaggagcgc cagctgttgg 5940 ggtaggtatt ccctctcgaa ggcgggcatg acctcggcac tcaggttgtc agtttctaga 6000 aacgaggagg atttgatatt gacggtgccg gcggagatgc ctttcaagag cccctcgtcc 6060 atctggtcag aaaagacgat ctttttgttg tcgagtttgg tggcgaagga gccgtagagg 6120 gcattggaga ggagcttggc gatagagcgc atggtctggt ttttttcctt gtcggcgcgc 6180 tccttggccg cgatgttgag ctgcacgtac tcgcgcgcca cgcacttcca ttcggggaag 6240 acggtggtca gctcgtcggg cacgattctg acttgccagc cccggttatg cagggtgatg 6300 aggtccacac tggtgcccac ctcgccgcgc aggggctcgt tggtccagca gagtcgaccg 6360 cccttgcgcg agcagaaggg gggcaggggg tccagcatga cctcgtcggg ggggtcggca 6420 tcgatggtga agatgcctgg caggagatcg gggtcgaagt agctgatgga agtggccaga 6480 tcgtccaggg cagcttgcca ttcgcgcacg gccagcgcgc gctcgtaggg actgaggggc 6540 gtgccccaag gcatggggtg tgtgagcgcg gaggcgtaca tgccgcagat gtcgtagacg 6600 tagaggggct cctcgaggat gccgatgtag gtggggtaac agcgcccccc gcggatgctg 6660 gcgcgcacgt agtcatacag ctcatgcgag ggggcgagga gccccgggcc caggttggtg 6720 cgactgggct tttcggcgcg gtagacgatc tggcgaaaga tggcatgcga gttggaggag 6780 atggtgggcc tttggaagat gttgaagtgg gcgtggggca gaccgaccga gtcgcggatg 6840 aagtgggcgt aggagtcttg cagtttggcg acgagctcgg cggtgacgag gacgtccaga 6900 gcgcagtagt cgagggtctc ctggatgatg tcatacttga gctggccctt ttgtttccac 6960 agctcgcggt tgagaaggaa ctcttcgcgg tccttccagt actcttcgag ggggaacccg 7020 tcctgatctg cacggtaaga gcctagcatg tagaactggt tgacggcctt gtaggcgcag 7080 cagcccttct ccacggggag ggcgtaggcc tgggcggcct tgcgcaggga ggtgtgcgtg 7140 agggcgaagg tgtccctgac catgaccttg aggaactggt gcttgaaatc gatatcgtcg 7200 cagcccccct gctcccagag ctggaagtcc gtgcgcttct tgtaggcggg gttgggcaaa 7260 gcgaaagtaa catcgttgaa aaggatcttg cccgcgcggg gcataaagtt gcgagtgatg 7320 cggaaaggct ggggcacctc ggcccggttg ttgatgacct gggcggcgag cacgatctcg 7380 tcgaaaccgt tgatgttgtg gcccacgatg tagagttcca cgaatcgcgg gcggcccttg 7440 acgtggggca gcttcttgag ctcctcgtag gtgagctcgt cggggtcgct gagaccgtgc 7500 tgctcgagcg cccagtcggc gagatggggg ttggcgcgga ggaaggaagt ccagagatcc 7560 acggccaggg cggtttgcag acggtcccgg tactgacgga actgctgccc gacggccatt 7620 ttttcggggg tgacgcagta gaaggtgcgg gggtccccgt gccagcggtc ccatttgagc 7680 tggagggcga gatcgagggc gagctcgacg aggcggtcgt ccccggagag tttcatgacc 7740 agcatgaagg ggacgagctg cttgccgaag gaccccatcc aggtgtaggt ttccacatcg 7800 taggtgagga agagcctttc ggtgcgagga tgcgagccga tggggaagaa ctggatctcc 7860 tgccaccaat tggaggaatg gctgttgatg tgatggaagt agaaatgccg acggcgcgcc 7920 gaacactcgt gcttgtgttt atacaagcgg ccacagtgct cgcaacgctg cacgggatgc 7980 acgtgctgca cgagctgtac ctgagttcct ttgacgagga atttcagtgg gaagtggagt 8040 cgtggcgcct gcatctcgtg ctgtactacg tcgtggtggt cggcctggcc ctcttctgcc 8100 tcgatggtgg tcatgctgac gagcccgcgc gggaggcagg tccagacctc ggcgcgagcg 8160 ggtcggagag cgaggacgag ggcgcgcagg ccggagctgt ccagggtcct gagacgctgc 8220 ggagtcaggt cagtgggcag cggcggcgcg cggttgactt gcaggagttt ttccagggcg 8280 cgcgggaggt ccagatggta cttgatctcc accgcgccgt tggtggcgac gtcgatggct 8340 tgcagggtcc cgtgcccctg gggtgtgacc accgtccccc gtttcttctt gggcggctgg 8400 ggcgacgggg gcggtgcctc ttccatggtt agaagcggcg gcgaggacgc gcgccgggcg 8460 gcagaggcgg ctcggggccc ggaggcaggg gcggcagggg cacgtcggcg ccgcgcgcgg 8520 gtaggttctg gtactgcgcc cggagaagac tggcgtgagc gacgacgcga cggttgacgt 8580 cctggatctg acgcctctgg gtgaaggcca cgggacccgt gagtttgaac ctgaaagaga 8640 gttcgacaga atcaatctcg gtatcgttga cggcggcctg ccgcaggatc tcttgcacgt 8700 cgcccgagtt gtcctggtag gcgatctcgg tcatgaactg ctcgatctcc tcctcctgaa 8760 ggtctccgcg gccggcgcgc tccacggtgg ccgcgaggtc gttggagatg cggcccatga 8820 gctgcgagaa ggcgttcatg cccgcctcgt tccagacgcg gctgtagacc acgacgccct 8880 cgggatcgcg ggcgcgcatg accacctggg cgaggttgag ctccacgtgg cgcgtgaaga 8940 ccgcgtagtt gcagaggcgc tggtagaggt agttgagcgt ggtggcgatg tgctcggtga 9000 cgaagaaata catgatccag cggcggagcg gcatctcgct gacgtcgccc agcgcctcca 9060 agcgttccat ggcctcgtaa aagtccacgg cgaagttgaa aaactgggag ttgcgcgccg 9120 agacggtcaa ctcctcctcc agaagacgga tgagctcggc gatggtggcg cgcacctcgc 9180 gctcgaaggc ccccgggagt tcctcctctt ccatctcctc ttcttcctcc tccactaaca 9240 tctcttctac ttcctcctca ggcggtggtg gcgggggagg gggcctgcgt cgccggcggc 9300 gcacgggcag acggtcgatg aagcgctcga tggtctcgcc gcgccggcgt cgcatggtct 9360 cggtgacggc gcgcccgtcc tcgcggggcc gcagcgtgaa gacgccgccg cgcatctcca 9420 ggtggccggg ggggtccccg ttgggcaggg agagggcgct gacgatgcat cttatcaatt 9480 gccccgtagg gactccgcgc aaggacctga gcgtctcgag atccacggga tctgaaaacc 9540 gttgaacgaa ggcttcgagc cagtcgcagt cgcaaggtag gctgagcacg gtttcttctg 9600 gcgggtcatg ttggggagcg gggcgggcga tgctgctggt gatgaagttg aaataggcgg 9660 ttctgagacg gcggatggtg gcgaggagca ccaggtcttt gggcccggct tgctggatgc 9720 gcagacggtc ggccatgccc caggcgtggt cctgacacct ggccaggtcc ttgtagtagt 9780 cctgcatgag ccgctccacg ggcacctcct cctcgcccgc gcggccgtgc atgcgcgtga 9840 gcccgaagcc gcgctggggc tggacgagcg ccaggtcggc gacgacgcgc tcggcgagga 9900 tggcctgctg gatctgggtg agggtggtct ggaagtcgtc aaagtcgacg aagcggtggt 9960 aggctccggt gttgatggtg taggagcagt tggccatgac ggaccagttg acggtctggt 10020 ggcccggacg cacgagctcg tggtacttga ggcgcgagta ggcgcgcgtg tcgaagatgt 10080 agtcgttgca ggtgcgcacc aggtactggt agccgatgag gaagtgcggc ggcggctggc 10140 ggtagagcgg ccatcgctcg gtggcggggg cgccgggcgc gaggtcctcg agcatggtgc 10200 ggtggtagcc gtagatgtac ctggacatcc aggtgatgcc ggcggcggtg gtggaggcgc 10260 gcgggaactc gcggacgcgg ttccagatgt tgcgcagcgg caggaagtag ttcatggtgg 10320 gcacggtctg gcccgtgagg cgcgcgcagt cgtggatgct ctatacgggc aaaaacgaaa 10380 gcggtcagcg gctcgactcc gtggcctgga ggctaagcga acgggttggg ctgcgcgtgt 10440 accccggttc gaatctcgaa tcaggctgga gccgcagcta acgtggtact ggcactcccg 10500 tctcgaccca agcctgcacc aaccctccag gatacggagg cgggtcgttt tgcaactttt 10560 tttcggaggc cggaaatgaa gactagtaag cgcggaaagc ggccgaccgc gatggctcgc 10620 tgccgtagtc tggagaagaa tcgccagggt tgcgttgcgg tgtgccccgg ttcgaggccg 10680 gccggattcc gcggctaacg agggcgtggc tgccccgtcg tttccaagac cccctagcca 10740 gccgacttct ccagttacgg agcgagcccc tcttttgttt tgtttgtttt tgccagatgc 10800 atcccgtact gcggcagatg cgcccccacc accctccacc gcaacaacag ccccctccac 10860 agccggcgct tctgcccccg ccccagcagc agcagcaact tccagccacg accgccgcgg 10920 ccgccgtgag cggggctgga cagacttctc agtatgacct ggccttggaa gagggcgagg 10980 ggctggcgcg cctgggggcg tcgtcgccgg agcggcaccc gcgcgtgcag atgaaaaggg 11040 acgctcgcga ggcctacgtg cccaagcaga acctgttcag agacaggagc ggcgaggagc 11100 ccgaggagat gcgcgcggcc cggttccacg cggggcggga gctgcggcgc ggcctggacc 11160 gaaagagggt gctgagggac gaggatttcg aggcggacga gctgacgggg atcagccccg 11220 cgcgcgcgca cgtggccgcg gccaacctgg tcacggcgta cgagcagacc gtgaaggagg 11280 agagcaactt ccaaaaatcc ttcaacaacc acgtgcgcac cctgatcgcg cgcgaggagg 11340 tgaccctggg cctgatgcac ctgtgggacc tgctggaggc catcgtgcag aaccccacca 11400 gcaagccgct gacggcgcag ctgttcctgg tggtgcagca tagtcgggac aacgaggcgt 11460 tcagggaggc gctgctgaat atcaccgagc ccgagggccg ctggctcctg gacctggtga 11520 acattctgca gagcatcgtg gtgcaggagc gcgggctgcc gctgtccgag aagctggcgg 11580 ccatcaactt ctcggtgctg agtctgggca agtactacgc taggaagatc tacaagaccc 11640 cgtacgtgcc catagacaag gaggtgaaga tcgacgggtt ttacatgcgc atgaccctga 11700 aagtgctgac cctgagcgac gatctggggg tgtaccgcaa cgacaggatg caccgcgcgg 11760 tgagcgccag caggcggcgc gagctgagcg accaggagct gatgcatagt ctgcagcggg 11820 ccctgaccgg ggccgggacc gagggggaga gctactttga catgggcgcg gacctgcact 11880 ggcagcccag ccgccgggcc ttggaggcgg caggcggtcc cccctacata gaagaggtgg 11940 acgatgaggt ggacgaggag ggcgagtacc tggaagactg atggcgcgac cgtatttttg 12000 ctagatgcaa caacagccac ctcctgatcc cgcgatgcgg gcggcgctgc agagccagcc 12060 gtccggcatt aactcctcgg acgattggac ccaggccatg caacgcatca tggcgctgac 12120 gacccgcaac cccgaagcct ttagacagca gccccaggcc aaccggctct cggccatcct 12180 ggaggccgtg gtgccctcgc gctccaaccc cacgcacgag aaggtcctgg ccatcgtgaa 12240 cgcgctggtg gagaacaagg ccatccgcgg cgacgaggcc ggcctggtgt acaacgcgct 12300 gctggagcgc gtggcccgct acaacagcac caacgtgcag accaacctgg accgcatggt 12360 gaccgacgtg cgcgaggccg tggcccagcg cgagcggttc caccgcgagt ccaacctggg 12420 atccatggtg gcgctgaacg ccttcctcag cacccagccc gccaacgtgc cccggggcca 12480 ggaggactac accaacttca tcagcgccct gcgcctgatg gtgaccgagg tgccccagag 12540 cgaggtgtac cagtccgggc cggactactt cttccagacc agtcgccagg gcttgcagac 12600 cgtgaacctg agccaggcgt tcaagaactt gcagggcctg tggggcgtgc aggccccggt 12660 cggggaccgc gcgacggtgt cgagcctgct gacgccgaac tcgcgcctgc tgctgctgct 12720 ggtggccccc ttcacggaca gcggcagcat caaccgcaac tcgtacctgg gctacctgat 12780 taacctgtac cgcgaggcca tcggccaggc gcacgtggac gagcagacct accaggagat 12840 cacccacgtg agccgcgccc tgggccagga cgacccgggc aatctggaag ccaccctgaa 12900 ctttttgctg accaaccggt cgcagaagat cccgccccag tacacgctca gcgccgagga 12960 ggagcgcatc ctgcgatacg tgcagcagag cgtgggcctg ttcctgatgc aggagggggc 13020 cacccccagc gccgcgctcg acatgaccgc gcgcaacatg gagcccagca tgtacgccag 13080 caaccgcccg ttcatcaata aactgatgga ctacttgcat cgggcggccg ccatgaactc 13140 tgactatttc accaacgcca tcctgaatcc ccactggctc ccgccgccgg ggttctacac 13200 gggcgagtac gacatgcccg accccaatga cgggttcctg tgggacgatg tggacagcag 13260 cgtgttctcc ccccgaccgg gtgctaacga gcgccccttg tggaagaagg aaggcagcga 13320 ccgacgcccg tcctcggcgc tgtccggccg cgagggtgct gccgcggcgg tgcccgaggc 13380 cgccagtcct ttcccgagct tgcccttctc gctgaacagt attcgcagca gcgagctggg 13440 caggatcacg cgcccgcgct tgctgggcga ggaggagtac ttgaatgact cgctgttgag 13500 acccgagcgg gagaagaact tccccaataa cgggatagag agcctggtgg acaagatgag 13560 ccgctggaag acgtatgcgc aggagcacag ggacgatccg tcgcaggggg ccacgagccg 13620 gggcagcgcc gcccgtaaac gccggtggca cgacaggcag cggggactga tgtgggacga 13680 tgaggattcc gccgacgaca gcagcgtgtt ggacttgggt gggagtggta acccgttcgc 13740 tcacctgcgc ccccgcatcg ggcgcatgat gtaagagaaa ccgaaaataa atgatactca 13800 ccaaggccat ggcgaccagc gtgcgttcgt ttcttctctg ttgttgtatc tagtatgatg 13860 aggcgtgcgt acccggaggg tcctcctccc tcgtacgaga gcgtgatgca gcaggcgatg 13920 gcggcggcgg cggcgatgca gcccccgctg gaggctcctt acgtgccccc gcggtacctg 13980 gcgcctacgg aggggcggaa cagcattcgt tactcggagc tggcaccctt gtacgatacc 14040 acccggttgt acctggtgga caacaagtcg gcggacatcg cctcgctgaa ctaccagaac 14100 gaccacagca acttcctgac caccgtggtg cagaacaatg acttcacccc cacggaggcc 14160 agcacccaga ccatcaactt tgacgagcgc tcgcggtggg gcggtcagct gaaaaccatc 14220 atgcacacca acatgcccaa cgtgaacgag ttcatgtaca gcaacaagtt caaggcgcgg 14280 gtgatggtct cccgcaagac ccccaacggg gtgacagtga cagatggtag tcaggatatc 14340 ttggagtatg aatgggtgga gtttgagctg cccgaaggca acttctcggt gaccatgacc 14400 atcgacctga tgaacaacgc catcatcgac aattacttgg cggtggggcg gcagaacggg 14460 gtcctggaga gcgatatcgg cgtgaagttc gacactagga acttcaggct gggctgggac 14520 cccgtgaccg agctggtcat gcccggggtg tacaccaacg aggccttcca ccccgatatt 14580 gtcttgctgc ccggctgcgg ggtggacttc accgagagcc gcctcagcaa cctgctgggc 14640 attcgcaaga ggcagccctt ccaggagggc ttccagatca tgtacgagga tctggagggg 14700 ggcaacatcc ccgcgctcct ggatgtcgac gcctatgaga aaagcaagga ggagagcgcc 14760 gccgcggcga ctgcagctgt agccaccgcc tctaccgagg tcaggggcga taattttgcc 14820 agccctgcag cagtggcagc ggccgaggcg gctgaaaccg aaagtaagat agtcattcag 14880 ccggtggaga aggatagcaa ggacaggagc tacaacgtgc tgccggacaa gataaacacc 14940 gcctaccgca gctggtacct ggcctacaac tatggcgacc ccgagaaggg cgtgcgctcc 15000 tggacgctgc tcaccacctc ggacgtcacc tgcggcgtgg agcaagtcta ctggtcgctg 15060 cccgacatga tgcaagaccc ggtcaccttc cgctccacgc gtcaagttag caactacccg 15120 gtggtgggcg ccgagctcct gcccgtctac tccaagagct tcttcaacga gcaggccgtc 15180 tactcgcagc agctgcgcgc cttcacctcg ctcacgcacg tcttcaaccg cttccccgag 15240 aaccagatcc tcgtccgccc gcccgcgccc accattacca ccgtcagtga aaacgttcct 15300 gctctcacag atcacgggac cctgccgctg cgcagcagta tccggggagt ccagcgcgtg 15360 accgttactg acgccagacg ccgcacctgc ccctacgtct acaaggccct gggcatagtc 15420 gcgccgcgcg tcctctcgag ccgcaccttc taaaaaatgt ccattctcat ctcgcccagt 15480 aataacaccg gttggggcct gcgcgcgccc agcaagatgt acggaggcgc tcgccaacgc 15540 tccacgcaac accccgtgcg cgtgcgcggg cacttccgcg ctccctgggg cgccctcaag 15600 ggccgcgtgc ggtcgcgcac caccgtcgac gacgtgatcg accaggtggt ggccgacgcg 15660 cgcaactaca cccccgccgc cgcgcccgtc tccaccgtgg acgccgtcat cgacagcgtg 15720 gtggccgacg cgcgccggta cgcccgcgcc aagagccggc ggcggcgcat cgc ccg 15776 Pro 1 gcg gca ccg gag cac ccc cgc cat gcg cgc ggc gcg agc ctt gct gcg 15824 Ala Ala Pro Glu His Pro Arg His Ala Arg Gly Ala Ser Leu Ala Ala 5 10 15 cag ggc cag gcg cac ggg acg cag ggc cat gct cag ggc ggc cag acg 15872 Gln Gly Gln Ala His Gly Thr Gln Gly His Ala Gln Gly Gly Gln Thr 20 25 30 cgc ggc ctc agg cgc cag cgc cgg cag gac ccg gag acg cgc ggc cac 15920 Arg Gly Leu Arg Arg Gln Arg Arg Gln Asp Pro Glu Thr Arg Gly His 35 40 45 ggc ggc ggc agc ggc cat cgc cag cat gtc ccg ccc gcg gcg agg gaa 15968 Gly Gly Gly Ser Gly His Arg Gln His Val Pro Pro Ala Ala Arg Glu 50 55 60 65 cgt gta ctg ggt gcg cga cgc cgc cac cgg tgt gcg cgt gcc cgt gcg 16016 Arg Val Leu Gly Ala Arg Arg Arg His Arg Cys Ala Arg Ala Arg Ala 70 75 80 cac ccg ccc ccc tcg cac ttg aag atg ttc act tcg cga tgt tga tgt 16064 His Pro Pro Pro Ser His Leu Lys Met Phe Thr Ser Arg Cys Cys 85 90 95 gtc cca gcg gcg agg atg tcc aag cgc aaa ttc aag gaa gag atg ctc 16112 Val Pro Ala Ala Arg Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu 100 105 110 cag gtc atc gcg cct gag atc tac ggc ccc gcg gtg gtg aag gag gaa 16160 Gln Val Ile Ala Pro Glu Ile Tyr Gly Pro Ala Val Val Lys Glu Glu 115 120 125 aga aag ccc cgc aaa atc aag cgg gtc aaa aag gac aaa aag gaa gaa 16208 Arg Lys Pro Arg Lys Ile Lys Arg Val Lys Lys Asp Lys Lys Glu Glu 130 135 140 gaa agt gat gtg gac gga ctg gtg gag ttt gtg cgc gag ttc gcc ccc 16256 Glu Ser Asp Val Asp Gly Leu Val Glu Phe Val Arg Glu Phe Ala Pro 145 150 155 160 cgg cgg cgc gtg cag tgg cgc ggg cgg aag gtg cgc ccg gtg ctg aga 16304 Arg Arg Arg Val Gln Trp Arg Gly Arg Lys Val Arg Pro Val Leu Arg 165 170 175 cca ggc act acg gtg gtc ttc acg ccc ggc gag cgc tcc ggc acc gct 16352 Pro Gly Thr Thr Val Val Phe Thr Pro Gly Glu Arg Ser Gly Thr Ala 180 185 190 tcc aag cgc tcc tac gac gag gtg tac ggg gac gag gac atc ctc gag 16400 Ser Lys Arg Ser Tyr Asp Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu 195 200 205 cag gcg gcc gag cgc ctg ggc gag ttt gct tac ggc aag cgc agc cgc 16448 Gln Ala Ala Glu Arg Leu Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg 210 215 220 tcc gcg ccg aag gaa gag gcg gtg tcc atc ccg ctg gac cac ggc aac 16496 Ser Ala Pro Lys Glu Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn 225 230 235 240 ccc acg ccg agc ctc aag ccc gtg acc ctg cag cag gtg ctg ccg acc 16544 Pro Thr Pro Ser Leu Lys Pro Val Thr Leu Gln Gln Val Leu Pro Thr 245 250 255 gcg gcg ccg cgc cgg ggg ttc aag cgc gag ggc gag gat ctg tac ccc 16592 Ala Ala Pro Arg Arg Gly Phe Lys Arg Glu Gly Glu Asp Leu Tyr Pro 260 265 270 acc atg cag ctg atg gtg ccc aag cgc cag aag ctg gaa gac gtg ctg 16640 Thr Met Gln Leu Met Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu 275 280 285 gag acc atg aag gtg gac ccg gac gtg cag ccc gag gtc aag gtg cgg 16688 Glu Thr Met Lys Val Asp Pro Asp Val Gln Pro Glu Val Lys Val Arg 290 295 300 ccc atc aag cag gtg gcc ccg ggc ctg ggc gtg cag acc gtg gac atc 16736 Pro Ile Lys Gln Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile 305 310 315 320 aag atc ccc acg gag ccc atg gaa acg cag acc gag ccc gtg aaa ccc 16784 Lys Ile Pro Thr Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro 325 330 335 agc acc agc acc atg gag gtg cag acg gat cct tgg atg cca tcg gct 16832 Ser Thr Ser Thr Met Glu Val Gln Thr Asp Pro Trp Met Pro Ser Ala 340 345 350 act agc cga aga ccc cgg cgc aag tac ggc gcg gcc agc ctg ctg atg 16880 Thr Ser Arg Arg Pro Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met 355 360 365 ccc aac tac gcg ctg cat cct tcc atc atc ccc acg ccg ggc tac cgc 16928 Pro Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg 370 375 380 ggc acg cgc ttc tac cgc ggt cat aca agc cgc cgc cgc aag acc acc 16976 Gly Thr Arg Phe Tyr Arg Gly His Thr Ser Arg Arg Arg Lys Thr Thr 385 390 395 400 acc cgc cgc cgc cgt cgc cgc aca acc gct gct gca tct acc cct gcc 17024 Thr Arg Arg Arg Arg Arg Arg Thr Thr Ala Ala Ala Ser Thr Pro Ala 405 410 415 gcc ctg gtg cgg aga gtg tac cgc cgc ggc cgc gcg cct ctg acc ctg 17072 Ala Leu Val Arg Arg Val Tyr Arg Arg Gly Arg Ala Pro Leu Thr Leu 420 425 430 ccg cgc gcg cgc tac cac ccg agc att gcc att taa act ttc gcc tgc 17120 Pro Arg Ala Arg Tyr His Pro Ser Ile Ala Ile Thr Phe Ala Cys 435 440 445 ttt gca gat caa tgg ccc tca cat gcc gcc tcc gcg ttc cca tta cgg 17168 Phe Ala Asp Gln Trp Pro Ser His Ala Ala Ser Ala Phe Pro Leu Arg 450 455 460 gct acc gag gaa gaa aac cgc gcc gta gaa ggc tgg cgg gga acg gga 17216 Ala Thr Glu Glu Glu Asn Arg Ala Val Glu Gly Trp Arg Gly Thr Gly 465 470 475 tgc gtc gcc acc acc acc ggc ggc ggc gcg cca tca gca agc ggt tgg 17264 Cys Val Ala Thr Thr Thr Gly Gly Gly Ala Pro Ser Ala Ser Gly Trp 480 485 490 495 ggg gag gct tcc tgc ccg cgc tga tcc cca tca tcg ccg cgg cga tcg 17312 Gly Glu Ala Ser Cys Pro Arg Ser Pro Ser Ser Pro Arg Arg Ser 500 505 510 ggg cga tcc ccg gca ttg ctt ccg tgg cgg tgc agg cct ctc agc gcc 17360 Gly Arg Ser Pro Ala Leu Leu Pro Trp Arg Cys Arg Pro Leu Ser Ala 515 520 525 act gag aca cacttggaaa catcttgtaa taaaccaatg gactctgacg 17409 Thr Glu Thr ctcctggtcc tgtgatgtgt tttcgtagac agatggaaga catcaatttt tcgtccctgg 17469 ctccgcgaca cggcacgcgg ccgttcatgg gcacctggag cgacatcggc accagccaac 17529 tgaacggggg cgccttcaat tggagcagtc tctggagcgg gcttaagaat ttcgggtcca 17589 cgcttaaaac ctatggcagc aaggcgtgga acagcaccac agggcaggcg ctgagggata 17649 agctgaaaga gcagaacttc cagcagaagg tggtcgatgg cctggcctcg ggcatcaacg 17709 gggtggtgga cctggccaac caggccgtgc agcggcagat caacagccgc ctggacccgg 17769 tgccgcccgc cggctccgtg gagatgccgc aggtggagga ggagctgcct cccctggaca 17829 agcggggcga gaagcgaccc cgccccgacg cggaggagac gctgctgacg cacacggacg 17889 agccgccccc gtacgaggag gcggtgaaac tgggcctgcc caccacgcgg cccatcgcgc 17949 ctctggccac cggggtgctg aaacccgaaa gtagtaagcc cgcgaccctg gacttgcctc 18009 ctccccagcc ttcccgcccc tccacagtgg ctaagcctct gccgccggtg gccgtggccc 18069 gcgcgcgacc cgggggcacc gcccgccctc atgcgaactg gcagagcact ctgaacagca 18129 tcgtgggtct gggagtgcag agtgtgaagc gccgccgctg ctattaaacc taccgtagcg 18189 cttaacttgc ttgtctgtgt gtgtatgtat tatgtcgccg ccgctgtcgc cagaaggagg 18249 agtgaagagg cgcgtcgccg agttgcaaga tggccacccc atcgatgctg ccccagtggg 18309 cgtacatgca catcgccgga caggacgctt cggagtacct gagtccgggt ctggtgcagt 18369 tcgcccgcgc cacagacacc tacttcagtc tggggaacaa gtttaggaac cccacggtgg 18429 cgcccacgca cgatgtgacc accgaccgca gccagcggct gacgctgcgc ttcgtgcccg 18489 tggaccgcga ggacaacacc tactcgtaca aagtgcgcta cacgctggcc gtgggcgaca 18549 accgcgtgct ggacatggcc agcacctact ttgacatccg cggcgtgctg gaccggggcc 18609 ctagcttcaa accctactcc ggcaccgcct acaatgctct ggcccccaag ggagcaccca 18669 acacttgcca gtggacatac acagataagc aaaccgaaaa aacagccacg tatgggaatg 18729 cgcctgtaca aggcattgcc atcacaaaag atggtattca acttggaact gacagtgatg 18789 gaaatcctgt atatgctcaa aagacatttg aacccgaacc tcaagtgggt gatgcagaat 18849 ggcatgacac tacaggtaca gatgaaaagt atggaggcag ggcacttaag cctgacacca 18909 aaatgaagcc ttgctatggt tcttttgcca aacccactaa caaagaaggt ggacaggcaa 18969 agaacagaac aaaaactgat ggaactggcg aagagcctga tattgatatg gcattttttg 19029 acggcagaaa tgcaactaca gctggtttgg ctccagaaat tgttttgtat actgagaatg 19089 tggatctgga gactccagat acccatattg tatacaaagc aggcacagat gacagcagct 19149 cttcgattaa tttggggcag caatccatgc ccaacagacc caactacatt gggttcagag 19209 acaactttat cgggctcatg tactacaaca gcactggcaa tatgggggtg ctggccggtc 19269 aggcttctca gctgaatgct gtggttgact tgcaagacag aaacaccgaa ctgtcctacc 19329 agctcttgct tgactctctg ggcgacagaa ccctgtattt cagtatgtgg aatcaggcgg 19389 tggacagcta tgatcctgat gtgcgcatta ttgaaaacca tggtgtggaa gatgaacttc 19449 ccaactattg cttccctctg gatgctgttg gtaggacaga tacttatcag ggaattaagc 19509 ccaatggagg cgatccagcc acatgggcca aagatgacag cgccaatgat gctaatgaaa 19569 tgggcaaggg caatccattc gccatggaaa tcaacatcca agccaacctg tggaggaact 19629 tcctctacgc caacgtggcc ctgtacctac ccgattctta caagtacacg ccggccaacg 19689 tcaccctgcc caccaacacc aacacctacg attatatgaa cggccgggtg gtggcgcctt 19749 cgctggtgga ctcctacatc aacatcgggg cgcgctggtc gctggacccc atggacaacg 19809 tcaatccctt caaccaccac cgcaacgcgg gcttgcgcta ccgctccatg ctcctgggca 19869 acgggcgcta cgtgcccttc cacatccagg tgccccagaa atttttcgcc atcaagagcc 19929 tcctgctcct gcccgggtcc tacacctacg agtggaactt ccgcaaggac gtcaacatga 19989 tcctgcagag ctccctcggc aacgacctgc gcacggacgg ggcctccatc tccttcacca 20049 gcatcaacct ctacgccacc ttcttcccca tggcgcacaa cacggcctcc acgctcgagg 20109 ccatgctgcg caacgacacc aacgaccagt ccttcaacga ctacctctcg gcggccaaca 20169 tgctctaccc catcccggcc aacgccacca acgtgcccat ctccatcccc tcgcgcaact 20229 gggccgcctt ccgcggctgg tccttcacgc gcctcaagac caaggagacg ccctcgctgg 20289 gctccgggtt cgacccctac ttcgtctact cgggctccat cccctacctc gacggcacct 20349 tctacctcaa ccacaccttc aagaaggtct ccatcacctt cgactcctcc gtcagctggc 20409 ccggcaacga ccggctcctg acgcccaacg agttcgaaat caagcgcacc gtcgacggcg 20469 agggctacaa cgtggcccag tgcaacatga ccaaggactg gttcctggtc cagatgctgg 20529 cccactacaa catcggctac cagggcttct acgtgcccga gggctacaag gaccgcatgt 20589 actccttctt ccgcaacttc cagcccatga gccgccaggt ggtggacgag gtcaactaca 20649 aggactacca ggccgtcacc ctggcctacc agcacaacaa ctcgggcttc gtcggctacc 20709 tcgcgcccac catgcgccag ggccagccct accccgccaa ctacccgtac ccgctcatcg 20769 gcaagagcgc cgtcaccagc gtcacccaga aaaagttcct ctgcgacagg gtcatgtggc 20829 gcatcccctt ctccagcaac ttcatgtcca tgggcgcgct caccgacctc ggccagaaca 20889 tgctctatgc caactccgcc cacgcgctag acatgaattt cgaagtcgac cccatggatg 20949 agtccaccct tctctatgtt gtcttcgaag tcttcgacgt cgtccgagtg caccagcccc 21009 accgcggcgt catcgaggcc gtctacctgc gcaccccctt ctcggccggt aacgccacca 21069 cctaaattgc tacttgcatg atggctgagg ccgcgggctc cggcgagcag gagctcaggg 21129 ccatcatccg cgacctgggc tgcgggccct acttcctggg caccttcgat aagcgcttcc 21189 cgggattcat ggccccgcac aagctggcct gcgccatcgt caacacggcc ggtcgcgaga 21249 ccgggggcga gcactggctg gccttcgcct ggaacccgcg ctcgaacacc tgctacctct 21309 tcgacccctt cgggttctcg gacgagcgcc tcaagcagat ctaccagttc gagtacgagg 21369 gcctgctgcg ccgcagcgcc ctggccaccg aggaccgctg cgtcaccctg gaaaagtcca 21429 cccagaccgt gcagggtccg cgctcggccg cctgcgggct cttctgctgc atgttcctgc 21489 acgccttcgt gcactggccc gaccgcccca tggacaagaa ccccaccatg aacttgctga 21549 cgggggtgcc caacggcatg ctccagtcgc cccaggtgga acccaccctg cgccgcaacc 21609 aggaggcgct ctaccgcttc ctcaactccc actccgccta ctttcgctcc caccgcgcgc 21669 gcatcgagaa ggccaccgcc ttcgatcgca tgaacaatca agacatgtaa accgtgtgtg 21729 tatgtttaaa atatctttta ataaacagca ctttcatgtt acacatgcat ctgagatgat 21789 tatttagaaa tcgaaagggt tctgccgggt ctcggcatgg cccgcgggca gggacacgtt 21849 gcggaactgg tacttggcca gccacttgaa ctcggggatc agcagtttcg gcagcggggt 21909 gtcggggaag gagtcggtcc acagcttccg cgtcagttgc agggcgccca gcaggtcggg 21969 cgcggagatc ttgaaatcgc agttgggacc cgcgttctgc gcgcgagagt tgcggtacac 22029 ggggttgcag cactggaaca ccatcagggc cgggtgcttc acgctcgcca gcaccgtcgc 22089 gtcggtgatg ctctccacgt cgaggtcctc ggcgttggcc atcccgaagg gggtcatctt 22149 gcaggtctgc cttcccatag tgggcacgca cccgggcttg tggttgcaat cgcagtgcag 22209 ggggatcagc atcatctggg cctggtcggc gttcatcccc gggtacatgg ccttcatgaa 22269 agcctccaat tgcctgaaag cctgctgggc cttggctccc tcggtgaaga agaccccgca 22329 ggacttgcta gagaactggt tggtagcgca cccggcgtcg tgcacgcagc agcgcgcgtc 22389 gttgttggcc agctgcacca cgctgcgccc ccagcggttc tgggtgatct tggcccggtc 22449 ggggttctcc ttcagcgcgc gctgcccgtt ctcgctcgcc acatccatct cgatcatgtg 22509 ctccttctgg atcatggtgg tcccgtgcag gcaccgcagc ttgccctcgg tctcggtgca 22569 cccgtgcagc cacagcgcgc acccggtgca ctcccagttc ttgtgggcga tctgggaatg 22629 cgcgtgcacg aacccctgca ggaagcggcc catcatggtg gtcagggtct tgttgctagt 22689 gaaggtcagc gggatgccgc ggtgctcctc gttgatgtac aggtggcaga tgcggcggta 22749 cacctcgccc tgctcgggca tcagctggaa gttggctttc aggtcggtct ccacgcggta 22809 gcggtccatc agtatagtca tgatttccat acccttctcc caggccgaga cgatgggcag 22869 gctcataggg ttcttcacca tcatcttagc actagcagcc gcggccaggg ggtcgctctc 22929 atccagggtc tcaaagctcc gcttgccgtc cttctcggtg atccgcaccg gggggtagct 22989 gaagcccacg gccgccagct cctcctcggc ctgcctttcg tcctcgctgt cctggctgac 23049 gtcctgcagg accacatgct tggtcttgcg gggtttcttc ttgggcggca gcggcggcgg 23109 agatgcttgt ggcgaggggg agcgcgagtt ctcgctcacc actactatct cttcctcttc 23169 gtggtccgag gccacgcggc ggtaggtatg tctcttcggg ggcagaggcg gaggcgacgg 23229 gctctcgccg ccgcgacttg gcggatggct ggcagagccc cttccgcgat cgggggtgcg 23289 ctcccggcgg cgctctgact gacttcctcc gcggccggcc attgtgttct cctagggagg 23349 aacaacaagc atg gag act cag cca tcg cca acc tcg cca tct gcc ccc 23398 Met Glu Thr Gln Pro Ser Pro Thr Ser Pro Ser Ala Pro 530 535 540 acc acc gcc gac gag aag cag cag aat gaa agc tta acc gcc ccg ccg 23446 Thr Thr Ala Asp Glu Lys Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro 545 550 555 ccc agc ccc gcc acc tcc gac gca gcc gcg gtc cca gac atg caa gag 23494 Pro Ser Pro Ala Thr Ser Asp Ala Ala Ala Val Pro Asp Met Gln Glu 560 565 570 atg gag gaa tcc atc gag att gac ctg ggc tat gtg acg ccc gcg gag 23542 Met Glu Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu 575 580 585 590 cac gag gag gag ctg gca gtg cgc ttt caa tcg tca agc cag gaa gat 23590 His Glu Glu Glu Leu Ala Val Arg Phe Gln Ser Ser Ser Gln Glu Asp 595 600 605 aaa gaa cag cca gag cag gaa gca gaa aac gag cag agt cag gct ggg 23638 Lys Glu Gln Pro Glu Gln Glu Ala Glu Asn Glu Gln Ser Gln Ala Gly 610 615 620 ctc gag cat gac ggc gac tac ctc cac ctg agc ggg gag gag gac gcg 23686 Leu Glu His Asp Gly Asp Tyr Leu His Leu Ser Gly Glu Glu Asp Ala 625 630 635 ctc atc aag cat ctg gcc cgg cag gcc atc atc gtc aag gat gcg ctg 23734 Leu Ile Lys His Leu Ala Arg Gln Ala Ile Ile Val Lys Asp Ala Leu 640 645 650 ctc gac cgc acc gag gtg ccc ctc agc gtg gag gag ctc agc cgc gcc 23782 Leu Asp Arg Thr Glu Val Pro Leu Ser Val Glu Glu Leu Ser Arg Ala 655 660 665 670 tac gag ctc aac ctc ttc tcg ccg cgc gtg ccc ccc aag cgc cag ccc 23830 Tyr Glu Leu Asn Leu Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro 675 680 685 aac ggc acc tgc gag ccc aac ccg cgc ctc aac ttc tac ccg gtc ttc 23878 Asn Gly Thr Cys Glu Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe 690 695 700 gcg gtg ccc gag gcc ctg gcc acc tac cac atc ttt ttc aag aac caa 23926 Ala Val Pro Glu Ala Leu Ala Thr Tyr His Ile Phe Phe Lys Asn Gln 705 710 715 aag atc ccc gtc tcc tgt cgc gcc aac cgc acc cgc gcc gac gcc ctc 23974 Lys Ile Pro Val Ser Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu 720 725 730 ttc aac ctg ggc ccc ggc gcc cgc cta cct gat atc gcc tcc ttg gaa 24022 Phe Asn Leu Gly Pro Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu 735 740 745 750 gag gtt ccc aag atc ttc gag ggt ctg ggc agc gac gag act cgg gcc 24070 Glu Val Pro Lys Ile Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala 755 760 765 gca aac gct ctg caa gga gaa gga gga gag cat gag cac cac agc gcc 24118 Ala Asn Ala Leu Gln Gly Glu Gly Gly Glu His Glu His His Ser Ala 770 775 780 ctg gtc gag ttg gaa ggc gac aac gcg cgg ctg gcg gtg ctc aaa cgc 24166 Leu Val Glu Leu Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg 785 790 795 acg gtc gag ctg acc cat ttc gcc tac ccg gct ctg aac ctg ccc ccc 24214 Thr Val Glu Leu Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro 800 805 810 aaa gtc atg agc gcg gtc atg gac cag gtg ctc atc aag cgc gcg tcg 24262 Lys Val Met Ser Ala Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser 815 820 825 830 ccc atc tcc gag gac gag ggc atg caa gac tcc gag gat ggc aag ccc 24310 Pro Ile Ser Glu Asp Glu Gly Met Gln Asp Ser Glu Asp Gly Lys Pro 835 840 845 gtg gtc agc gac gag cag ctg gcc cgg tgg ctg ggt cct aat gct agt 24358 Val Val Ser Asp Glu Gln Leu Ala Arg Trp Leu Gly Pro Asn Ala Ser 850 855 860 ccc cag agt ttg gaa gag cgg cgc aag ctc atg atg gcc gtg gtc ctg 24406 Pro Gln Ser Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu 865 870 875 gtg acc gtg gag ctg gag tgc ctg cgc cgc ttc ttc gcc gac gcg gag 24454 Val Thr Val Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu 880 885 890 acc ctg cgc aag gtc gag gag aac ctg cac tac ctc ttc agg cac ggg 24502 Thr Leu Arg Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly 895 900 905 910 ttc gtg cgc cag gcc tgc aag atc tcc aac gtg gag ctg acc aac ctg 24550 Phe Val Arg Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu 915 920 925 gtc tcc tac atg ggc atc ttg cac gag aac cgc ctg ggg cag aac gtg 24598 Val Ser Tyr Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val 930 935 940 ctg cac acc acc ctg cgc ggg gag gcc cgc cgc gac tac atc cgc gac 24646 Leu His Thr Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp 945 950 955 tgc gtc tac ctc tac ctc tgc cac acc tgg cag acg ggc atg ggc gtg 24694 Cys Val Tyr Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val 960 965 970 tgg cag cag tgt ctg gag gag cag aac ctg aaa gag ctc tgc aag ctc 24742 Trp Gln Gln Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu 975 980 985 990 ctg cag aag aac ctc aag ggt ctg tgg acc ggg ttc gac gag cgg acc 24790 Leu Gln Lys Asn Leu Lys Gly Leu Trp Thr Gly Phe Asp Glu Arg Thr 995 1000 1005 acc gcc tcg gac ctg gcc gac ctc atc ttc ccc gag cgc ctc agg 24835 Thr Ala Ser Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg 1010 1015 1020 ctg acg ctg cgc aac ggc ctg ccc gac ttt atg agc caa agc atg 24880 Leu Thr Leu Arg Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met 1025 1030 1035 ttg caa aac ttt cgc tct ttc atc ctc gaa cgc tcc gga atc ctg 24925 Leu Gln Asn Phe Arg Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu 1040 1045 1050 ccc gcc acc tgc tcc gcg ctg ccc tcg gac ttc gtg ccg ctg acc 24970 Pro Ala Thr Cys Ser Ala Leu Pro Ser Asp Phe Val Pro Leu Thr 1055 1060 1065 ttc cgc gag tgc ccc ccg ccg ctg tgg agc cac tgc tac ctg ctg 25015 Phe Arg Glu Cys Pro Pro Pro Leu Trp Ser His Cys Tyr Leu Leu 1070 1075 1080 cgc ctg gcc aac tac ctg gcc tac cac tcg gac gtg atc gag gac 25060 Arg Leu Ala Asn Tyr Leu Ala Tyr His Ser Asp Val Ile Glu Asp 1085 1090 1095 gtc agc ggc gag ggc ctg ctt gag tgc cac tgc cgc tgc aac ctc 25105 Val Ser Gly Glu Gly Leu Leu Glu Cys His Cys Arg Cys Asn Leu 1100 1105 1110 tgc acg ccg cac cgc tcc ctg gcc tgc aac ccc cag ctg ctg agc 25150 Cys Thr Pro His Arg Ser Leu Ala Cys Asn Pro Gln Leu Leu Ser 1115 1120 1125 gag acc cag atc atc ggc acc ttc gag ttg caa ggg ccc agc gat 25195 Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln Gly Pro Ser Asp 1130 1135 1140 gac ggc gag gga gcc aag ggg ggt ctg aaa ctc acc ccg ggg ctg 25240 Asp Gly Glu Gly Ala Lys Gly Gly Leu Lys Leu Thr Pro Gly Leu 1145 1150 1155 tgg acc tcg gcc tac ttg cgc aag ttc gtg ccc gag gac tac cat 25285 Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr His 1160 1165 1170 ccc ttc gag atc agg ttc tac gag gac caa tcc cag ccg cct aag 25330 Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys 1175 1180 1185 gcc gag ctg tcg gcc tgc gtc atc acc cag ggg gcc atc ctg gcc 25375 Ala Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala 1190 1195 1200 caa ttg caa gcc atc cag aaa tcc cgc caa gaa ttc ttg ctg aaa 25420 Gln Leu Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys 1205 1210 1215 aag ggc cgc ggg gtc tac ctc gac ccc cag acc ggt gag gag ctc 25465 Lys Gly Arg Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu 1220 1225 1230 aac ccc ggc ttc ccc cag gat gcc ccg agg aaa caa gaa gct gaa 25510 Asn Pro Gly Phe Pro Gln Asp Ala Pro Arg Lys Gln Glu Ala Glu 1235 1240 1245 agt gga gct gcc gcc cgt gga gga ttt gga gga aga ctg gga gaa 25555 Ser Gly Ala Ala Ala Arg Gly Gly Phe Gly Gly Arg Leu Gly Glu 1250 1255 1260 cag cag tca ggc aga gga gga gat gga gga aga ctg gga cag cac 25600 Gln Gln Ser Gly Arg Gly Gly Asp Gly Gly Arg Leu Gly Gln His 1265 1270 1275 tca ggc aga gga gga cag cct gca aga cag tct gga gga aga cga 25645 Ser Gly Arg Gly Gly Gln Pro Ala Arg Gln Ser Gly Gly Arg Arg 1280 1285 1290 gga gga ggc aga ggt gga aga agc agc cgc cgc cag acc gtc gtc 25690 Gly Gly Gly Arg Gly Gly Arg Ser Ser Arg Arg Gln Thr Val Val 1295 1300 1305 ctc ggc ggg gga gaa agc aag cag cac gga tac cat ctc cgc tcc 25735 Leu Gly Gly Gly Glu Ser Lys Gln His Gly Tyr His Leu Arg Ser 1310 1315 1320 ggg tcg ggg tcc cgc tcg gcc cca cag tagatgggac gagaccgggc 25782 Gly Ser Gly Ser Arg Ser Ala Pro Gln 1325 1330 gattcccgaa ccccaccatc cagaccggta agaaggagcg gcagggatac aagtcctggc 25842 gggggcacaa aaacgccatc gtctcctgct tgcaggcctg cgggggcaac atctccttca 25902 ccaggcgcta cctgctcttc caccgcgggg tgaacttccc ccgcaacatc ttgcattact 25962 accgtcacct ccacagcccc tactacttcc aagaagaggc agcagcagaa aaagaccagc 26022 agaaaaccag cagctagaaa atccacagcg gcagcaggtg gactgaggat cgcggcgaac 26082 gagccggcgc agacccggga gctgaggaac cggatctttc ccaccctcta tgccatcttc 26142 cagcagagtc gggggcagga gcaggaactg aaagtcaaga accgttctct gcgctcgctc 26202 acccgcagtt gtctgtatca caagagcgaa gaccaacttc agcgcactct cgaggacgcc 26262 gaggctctct tcaacaagta ctgcgcgctc actcttaaag agtagcccgc gcccgcccag 26322 tcgcagaaaa aggcgggaat tacgtcacct gtgcccttcg ccctagccgc ctccacccat 26382 catgagcaaa gagattccca cgccttacat gtggagctac cagccccaga tgggcctggc 26442 cgccggcgcc gcccaggact actccacccg catgaattgg ctcagcgccg ggcccgcgat 26502 gatctcacgg gtgaatgaca tccgcgccca ccgaaaccag atactcctag aacagtcagc 26562 gctcaccgcc acgccccgca atcacctcaa tccgcgtaat tggcccgccg ccctggtgta 26622 ccaggaaatt ccccagccca cgaccgtact acttccgcga gacgcccagg ccgaagtcca 26682 gctgactaac tcaggtgtcc agctggcggg cggcgccacc ctgtgtcgtc accgccccgc 26742 tcagggtata aagcggctgg tgatccgggg cagaggcaca cagctcaacg acgaggtggt 26802 gagctcttcg ctgggtctgc gacctgacgg agtcttccaa atcgccggat cggggagatc 26862 ttccttcacg cctcgtcagg cggtcctgac tttggagagt tcgtcctcgc agccccgctc 26922 gggcggcatc ggcactctcc agttcgtgga ggagttcact ccctcggtct acttcaaccc 26982 cttctccggc tcccccggcc actacccgga cgagttcatc ccgaactttg acgccatcag 27042 cgagtcggtg gacggctacg attgaatgtc ccatggtggc gcggctgacc tagctcggct 27102 tcgacacctg gaccactgcc gccgctttcg ctgcttcgct cgggacctcg ccgagttcac 27162 ctacttcgag ctgcccgagg agcatcctca gggcccggcc cacggagtgc ggatcgtcgt 27222 cgaagggggc ctagactccc acctgcttcg gatcttcagc cagcgcccga tcctggtcga 27282 gcgccaacag ggcaacaccc tcctgaccct ctactgcatc tgcgaccacc ccggcctgc 27341 atg aaa gtc ttt gtt gtc tgc tgt gta ctg agt ata ata aaa gct 27386 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala 1335 1340 1345 gag atc agc gac tac tcc gga ctc aac tgt ggt gtt tct gca tcc 27431 Glu Ile Ser Asp Tyr Ser Gly Leu Asn Cys Gly Val Ser Ala Ser 1350 1355 1360 atc aac cag tct ctg acc ttc acc ggg aac gag acc gag ctc cag 27476 Ile Asn Gln Ser Leu Thr Phe Thr Gly Asn Glu Thr Glu Leu Gln 1365 1370 1375 ctc cag tgt aag ccc cac aag aag tac ctc acc tgg ctg tac cag 27521 Leu Gln Cys Lys Pro His Lys Lys Tyr Leu Thr Trp Leu Tyr Gln 1380 1385 1390 ggc tcc ccg atc gcc gtt gtt aac cac tgc gac gac gac gga gtc 27566 Gly Ser Pro Ile Ala Val Val Asn His Cys Asp Asp Asp Gly Val 1395 1400 1405 ctg ctg aac ggc ccc gcc aac ctt act ttt tcc acc cgc aga agc 27611 Leu Leu Asn Gly Pro Ala Asn Leu Thr Phe Ser Thr Arg Arg Ser 1410 1415 1420 aag cta ctg ctc ttc aga ccc ttc ctc ccc ggg atc tat cag tgc 27656 Lys Leu Leu Leu Phe Arg Pro Phe Leu Pro Gly Ile Tyr Gln Cys 1425 1430 1435 atc tcg gga ccc tgc cat cac acc ttc cac ctg atc ccg aat acc 27701 Ile Ser Gly Pro Cys His His Thr Phe His Leu Ile Pro Asn Thr 1440 1445 1450 acc tct tcc cca gca ccg ctc ccc act aac aac caa act aac cac 27746 Thr Ser Ser Pro Ala Pro Leu Pro Thr Asn Asn Gln Thr Asn His 1455 1460 1465 caa cgc cac cgt cga gac ctt tcc tct gat tct aat acc act acc 27791 Gln Arg His Arg Arg Asp Leu Ser Ser Asp Ser Asn Thr Thr Thr 1470 1475 1480 gga ggt gag ctc cga ggt act aag aag tcc tca cct ggg att tat 27836 Gly Gly Glu Leu Arg Gly Thr Lys Lys Ser Ser Pro Gly Ile Tyr 1485 1490 1495 tac ggc ccc tgg gag gtg gtg ggg tta ata gct tta ggc tta gta 27881 Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val 1500 1505 1510 gcg ggt ggg ctt ttg gct ctc tgc tac cta tac ctc cct tgc tgt 27926 Ala Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys 1515 1520 1525 tcc tac tta gtg gtg ctt tgt tgc tgg ttt aag aaa tgg gga aga 27971 Ser Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg 1530 1535 1540 tca ccc tagtgtgcgg tgtgctggtg acggtggtgc tttcgattct gggaggggga 28027 Ser Pro agcgcggctg tagtgacgga gaagaaggcc gatccctgct tgactttcaa tcccgataaa 28087 tgccggctga gttttcagcc agatggcaat cggtgcacgg tgctgatcaa gtgcggatgg 28147 gaatgcgaga gcgtggcgat ccagtataaa aacaagacgc ggaacaatac tctcgcgtcc 28207 acatggcagc ccggggaccc cgagtggtac accgtctctg tccctggtgc tgacggctcc 28267 ctccacacgg tgaacaacac tttcattttt gagcacatgt gcgaaaccgc catgttcatg 28327 agcaagcagt acggtatgtg gcccccacga aaagagaata tcgtggtctt ctccatcgct 28387 tacagcgcgt gcacggtgct aatcaccgcg atcgtgtgcc tgagcattca catgctcatc 28447 gctattcgcc ccagaaataa tgccgagaaa gagaaacagc cataacacac ttttttcaca 28507 caccttgttt tttacagaca atgcgtctgt taatttttgt tatcattaca ctcagcttta 28567 actatgccca tggctatgca aatatacaaa aaaccctcta tgtaggctct gactctacat 28627 tagaaggtac tcaatctcaa gccagggttt catggtattt ttataaaggc tctgatgacc 28687 caattactct ttgcaaaggt gatcaggggc gcataacaaa gccacctatc acatttagct 28747 gcaccagaac aaacctcacg cttttatcca ttacaaaaga atatgctggc acttattaca 28807 gcacaaattt tcatcgtggg caagataaat attatactgt taaggtagaa aaccctacca 28867 cccctagaac aactacaaag cccaccacaa ctaagaagcc cactacacct aagaagccta 28927 ccacacccaa aaccactaag acaacaactg ctaagaccac taccacaaag ccaaccacaa 28987 ccagcaccac acttgctata actacacaca cacacactga gctgacctca caggcaacta 29047 ctgaaaatga tttggttgcc ctgttgcaaa agggggagaa cagtagcagc agtcctctgc 29107 ctactacccc cagtgaggaa atacccaagt ccatggttgg cattatcgct gctgtagtgg 29167 tgtgtatgct gattatcatc ttgtgcatga tgtactatgc ctgctactac agaaaacaca 29227 ggctgaacaa caaactggac cccttactga gtgttgattt ttaatttttt agaaccatga 29287 agatcctaag cctttttgtt ttttctataa ttattacctc tgctatttgt gaatcagtgg 29347 ataaggacgt tactgtcacc actggctcta attatacact aaaagggcct tcctcaggta 29407 tgctttcgtg gtattgttat tttggaaatg atgataaaca gacagagcta tgtaactttc 29467 agaacggcaa aaccaaaaat tctaaaatag ataactatca atgccagggt actaatttag 29527 tactgatgaa tatcacgaaa gcatatgctg gcagttattc ctgtcctgga caaaacaccg 29587 aggaaatgat tttttacaaa ttaattgtag ttgaccctac tactccagca ccacccacca 29647 caaccaaggc acataccaca gacacacagg aaaccactcc agaggcagaa gtagcagagt 29707 tagcaaagca gattcatgaa gattcatttg ttgccaatac ccccacacac cccggaccgc 29767 aatgtccagg gccattagtc agcggcattg tcggtgtgct ttgcgggtta gcagttataa 29827 tcatctgcat gttcattttt gcttgctgct acagaaggct tcaccgacaa aaatcagacc 29887 cactgctgaa cctctatgtt taatttttga ttttccagag ccatgaaggc acttagcact 29947 ttagtatttt tgtccttgat tggcattgtt ttcagtgctg ggtttttgaa aaatcttacc 30007 attattgaag gtgataatgc aacactggta ggaatcagcg gtcagaatgt tagttggcta 30067 aaatatcatc tagatgggtg gaaacctatt tgcacctgga atgtcagtgt gtacacatgc 30127 catggtgtta acctcaccat taccaatgcc acccaagatc agaatggcag gtttaagggt 30187 cagagtttca ctagcaacaa tgggtatgaa acccataaca tgttcatcta tgatgtcact 30247 gtcatatcaa ataagactac acctaccaca cagacaccca ctacacatag ctcaactcat 30307 gccatgcaga ccactcagac aaccacatac actacatcta ctgagtccac caccaccact 30367 acagcagagg tatccagcac agcgcctcag ccccaggcat tggctttgat ggctcagcct 30427 agcagcatga ctgctaaaac caatgagcag actactgaat ttttgtccac tattcagagc 30487 agcaccacag ctacctcgag tgccttctct agcaccgcca atctcacctc gctttcctct 30547 acgccaatca gtaacgctac tacctccccc gctcctcttc ccactcctct gaagcaatcc 30607 gagtctagca cgcagctgca gatcaccctg ctcattgtga tcggggtggt catcctggca 30667 gtgctgctct actttatctt ctgccgccgc atccccaacg cgaaaccggc ctacaagccc 30727 attgttatcg ggacgccgga gccgcttcag gtggagggag gtctaaggaa tcttctcttc 30787 tcttttacag tatggtgatt tgaactatga ttcctagaca tttcattatc acttctctaa 30847 tctgtgtgct ccaagtctgt gccaccctcg ctctcgtggc taacgcgagt ccagactgca 30907 ttggagcgtt cgcctcctac gtgctctttg ccttcatcac ctgcatctgc tgctgtagca 30967 tagtctgcct gcttatcacc ttcttccagt tcgttgactg ggtctttgtg cgcatcgcct 31027 acctgcgcca ccacccccag taccgcgacc agagagtggc gcaactgttg agactcatct 31087 g atg ata agc atg cgg gct ctg cta cta ctt ctc gcg ctt ctg cta 31133 Met Ile Ser Met Arg Ala Leu Leu Leu Leu Leu Ala Leu Leu Leu 1545 1550 1555 gct ccc ctc gcc gcc ccc cta tcc ctc aaa tcc ccc acc cag tcc 31178 Ala Pro Leu Ala Ala Pro Leu Ser Leu Lys Ser Pro Thr Gln Ser 1560 1565 1570 cct gaa gag gtt cga aaa tgt aaa ttc caa gaa ccc tgg aaa ttc 31223 Pro Glu Glu Val Arg Lys Cys Lys Phe Gln Glu Pro Trp Lys Phe 1575 1580 1585 ctt tca tgc tac aaa ctc aaa tca gaa atg cac ccc agc tgg atc 31268 Leu Ser Cys Tyr Lys Leu Lys Ser Glu Met His Pro Ser Trp Ile 1590 1595 1600 atg atc gtt gga atc gta aac atc ctt gcc tgt acc ctc ttc tcc 31313 Met Ile Val Gly Ile Val Asn Ile Leu Ala Cys Thr Leu Phe Ser 1605 1610 1615 ttt gtg att tac ccc cgc ttt gac ttt ggg tgg aac gca ccc gag 31358 Phe Val Ile Tyr Pro Arg Phe Asp Phe Gly Trp Asn Ala Pro Glu 1620 1625 1630 gcg ctc tgg ctc ccg cct gat ccc gac aca cca cca cag cag cag 31403 Ala Leu Trp Leu Pro Pro Asp Pro Asp Thr Pro Pro Gln Gln Gln 1635 1640 1645 caa aat cag gca cag gca cat gca cca cca cag cct agg cca caa 31448 Gln Asn Gln Ala Gln Ala His Ala Pro Pro Gln Pro Arg Pro Gln 1650 1655 1660 tac atg ccc atc tta gac tat gag gcc gag cca cag cga gcc atg 31493 Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg Ala Met 1665 1670 1675 ctt cct gct att agt tac ttc aat cta acc ggc gga gat gac 31535 Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 1680 1685 1690 tgaccccatg gccaacaaca ccgtcaacga cctcctggac atggacggcc gcgcctcgga 31595 gcagcgactc gcccaactcc gcatccgcca gcagcaggag agagccgtca aggagctgca 31655 ggacgcggtg gccatccacc agtgcaagag aggcatcttc tgcctggtga agcaggccaa 31715 gatctccttc gaggtcacgt ccaccgacca tcgcctctcc tacgagctcc tgcagcagcg 31775 ccagaagttc acctgcctgg tcggagtcaa ccccatcgtc atcacccagc agtctggcga 31835 taccaagggt tgcatccact gctcctgcga ctcccccgag tgcgttcaca ccctgatcaa 31895 gaccctctgc ggcctccgcg acctcctccc catgaactaa tcaactaacc ccctacccct 31955 ttaccctcca gtaaaaataa agattaaaaa tgattgaatt gatcaataaa gaatcactta 32015 cttgaaatct gaaaccaggt ctctgtccat gttttctgtc agcagcactt cactcccctc 32075 ttcccaactc tggtactgca ggccccggcg ggctgcaaac ttcctccaca ctctgaaggg 32135 gatgtcaaat tcctcctgtc cctcaatctt catttttatc ttctatcaga tgtccaaaaa 32195 gcgcgcgcgg gtggatgatg gcttcgaccc cgtgtacccc tacgatgcag acaacgcacc 32255 gactgtgccc ttcatcaacc ctcccttcgt ctcttcagat ggattccaag aaaagcccct 32315 gggggtgttg tccctgcgac tggccgaccc cgtcaccacc aagaatgggg ctgtcaccct 32375 caagctgggg gagggggtgg acctcgacga ctcgggaaaa ctcatctcca aaaatgccac 32435 caaggccact gcccctctca gtatttccaa cggcaccatt tcccttaaca tggccgcccc 32495 tttttacaac aacaatggaa cgttaagtct caatgtttct acaccattag cagtatttcc 32555 cacttttaac actttaggta tcagtcttgg aaacggtctt caaacttcta ataagttgct 32615 gactgtacag ttaactcatc ctcttacatt cagctcaaat agcatcacag taaaaacaga 32675 caaaggactc tatattaatt ctagtggaaa cagagggctt gaggctaaca taagcctaaa 32735 aagaggactg atttttgatg gtaatgctat tgcaacatac cttggaagtg gtttagacta 32795 tggatcctat gatagcgatg ggaaaacaag acccatcatc accaaaattg gagcaggttt 32855 gaattttgat gctaataatg ccatggctgt gaagctaggc acaggtttaa gttttgactc 32915 tgccggtgcc ttaacagctg gaaacaaaga ggatgacaag ctaacacttt ggactacacc 32975 tgacccaagc cctaattgtc aattactttc agacagagat gccaaattta ccctatgtct 33035 tacaaaatgc ggtagtcaaa tactaggcac tgttgcagta gctgctgtta ctgtaggttc 33095 agcactaaat ccaattaatg acacagtaaa aagcgccata gtattcctta gatttgactc 33155 tgacggtgtg ctcatgtcaa actcatcaat ggtaggtgat tactggaact ttagggaagg 33215 acagaccacc caaagtgtgg cctatacaaa tgctgtggga ttcatgccca atctaggtgc 33275 atatcctaaa acccaaagca aaacaccaaa aaatagtata gtaagtcagg tatatttaaa 33335 tggagaaact actatgccaa tgacactgac aataactttc aatggcactg atgaaaaaga 33395 cacaacacct gtgagcactt actccatgac ttttacatgg cagtggactg gagactataa 33455 ggacaagaat attacctttg ctaccaactc ctttactttc tcctacatgg cccaagaata 33515 aaccctgcat gccaacccca ttgttcccac cactatggaa aactctgaag cagaaaaaaa 33575 taaagttcaa gtgttttatt gattcaacag ttttcacaga attcgagtag ttattttccc 33635 tcctccctcc caactcatgg aatacaccac cctctcccca cgcacagcct taaacatctg 33695 aatgccattg gtaatggaca tggttttggt ctccacattc cacacagttt cagagcgagc 33755 cagtctcggg tcggtcaggg agatgaaacc ctccgggcac tcctgcatct gcacctcaaa 33815 gttcagtagc tgagggctgt cctcggtggt cgggatcaca gttatctgga agaagagcgg 33875 tgagagtcat aatccgcgaa cgggatcggg cggttgtggc gcatcaggcc ccgcagcagt 33935 cgctgtctgc gccgctccgt caagctgctg ctcaaggggt ctgggtccag ggactccctg 33995 cgcatgatgc cgatggccct gagcatcagt cgcctggtgc ggcgggcgca gcagcggatg 34055 cggatctcac tcaggtcgga gcagtacgtg cagcacagca ctaccaagtt gttcaacagt 34115 ccatagttca acgtgctcca gccaaaactc atctgtggaa ctatgctgcc cacatgtcca 34175 tcgtaccaga tcctgatgta aatcaggtgg cgccccctcc agaacacact gcccatgtac 34235 atgatctcct tgggcatgtg caggttcacc acctcccggt accacatcac ccgctggttg 34295 aacatgcagc cctggataat cctgcggaac cagatggcca gcaccgcccc gcccgccatg 34355 cagcgcaggg accccgggtc ctggcaatgg cagtggagca cccaccgctc acggccgtgg 34415 attaactggg agctgaacaa gtctatgttg gcacagcaca ggcacacgct catgcatgtc 34475 ttcagcactc tcagttcctc gggggtcagg accatgtccc agggcacggg gaactcttgc 34535 aggacagtga acccggcaga acagggcagc cctcgcacac aacttacatt gtgcatggac 34595 agggtatcgc aatcaggcag caccggatga tcctccacca gagaagcgcg ggtctcggtc 34655 tcctca cag cga ggt aag ggg gcc ggc ggt tgg tac gga tga tgg cgg 34703 Gln Arg Gly Lys Gly Ala Gly Gly Trp Tyr Gly Trp Arg 1695 1700 gat gac gct aat cgt gtt ctg gat cgt gtc atg atg gag ctg ttt 34748 Asp Asp Ala Asn Arg Val Leu Asp Arg Val Met Met Glu Leu Phe 1705 1710 1715 cct gac att ttc gta ctt cac gaa gca gaa cct ggt acg ggc act 34793 Pro Asp Ile Phe Val Leu His Glu Ala Glu Pro Gly Thr Gly Thr 1720 1725 1730 gca cac cgc tcg ccg gcg acg gtc tcg gcg ctt cga gcg ctc ggt 34838 Ala His Arg Ser Pro Ala Thr Val Ser Ala Leu Arg Ala Leu Gly 1735 1740 1745 gtt gaa gtt ata gaa cag cca ctc cct cag agc gtg cag tat ctc 34883 Val Glu Val Ile Glu Gln Pro Leu Pro Gln Ser Val Gln Tyr Leu 1750 1755 1760 ctg agc ctc ttg ggt gat gaa aat ccc atc cgc tct gat ggc tct 34928 Leu Ser Leu Leu Gly Asp Glu Asn Pro Ile Arg Ser Asp Gly Ser 1765 1770 1775 gat cac atc ggc cac ggt gga atg ggc cag acc cag cca gat gat 34973 Asp His Ile Gly His Gly Gly Met Gly Gln Thr Gln Pro Asp Asp 1780 1785 1790 gca att ttg ttg ggt ttc ggt gac gga ggg aga ggg aag aac agg 35018 Ala Ile Leu Leu Gly Phe Gly Asp Gly Gly Arg Gly Lys Asn Arg 1795 1800 1805 aag aac cat gattaacttt attccaaacg gtctcggagc acttcaaaat 35067 Lys Asn His 1810 gcaggtcccg gaggtggcac ctctcgcccc cactgtgttg gtggaaaata acagccaggt 35127 caaaggtgac acggttctcg agatgttcca cggtggcttc cagcaaagcc tccacgcgca 35187 catccagaaa caagaggaca gcgaaagcgg gagcgttttc taattcctca atcatcatat 35247 tacactcctg caccatcccc agataatttt catttttcca gccttgaatg attcgtatta 35307 gttcctgagg taaatccaag ccagccatga taaaaagctc gcgcagagcg ccctccaccg 35367 gcattcttaa gcacaccctc a taa ttc caa gag att ctg ctc ctg gtt cac 35418 Phe Gln Glu Ile Leu Leu Leu Val His 1815 1820 ctg cag cag att aac aat ggg aat atc aaa atc tct gcc gcg atc 35463 Leu Gln Gln Ile Asn Asn Gly Asn Ile Lys Ile Ser Ala Ala Ile 1825 1830 1835 cct aag ctc ctc cct caa caa taa ctg tat gta atc ttt cat atc 35508 Pro Lys Leu Leu Pro Gln Gln Leu Tyr Val Ile Phe His Ile 1840 1845 1850 atc tcc gaa att ttt agc cat agg gcc gcc agg aat aag agc agg 35553 Ile Ser Glu Ile Phe Ser His Arg Ala Ala Arg Asn Lys Ser Arg 1855 1860 1865 gca agc cac att aca gat aaa gcg aag tcc tcc cca gtg agc att 35598 Ala Ser His Ile Thr Asp Lys Ala Lys Ser Ser Pro Val Ser Ile 1870 1875 1880 gcc aaa tgt aag att gaa ata agc atg ctg gct aga ccc tgt gat 35643 Ala Lys Cys Lys Ile Glu Ile Ser Met Leu Ala Arg Pro Cys Asp 1885 1890 1895 atc ttc cag ata act gga cag aaa atc agg caa gca att ttt aag 35688 Ile Phe Gln Ile Thr Gly Gln Lys Ile Arg Gln Ala Ile Phe Lys 1900 1905 1910 aaa atc aac aaa aga aaa gtc gtc cag gtg cag gtt tag agc ctc 35733 Lys Ile Asn Lys Arg Lys Val Val Gln Val Gln Val Ser Leu 1915 1920 agg aac aac gat gga ata agt gca agg agt gcg ttc cag cat 35775 Arg Asn Asn Asp Gly Ile Ser Ala Arg Ser Ala Phe Gln His 1925 1930 1935 ggttagtgtt tttttggtga tctgtagaac aaaaaataaa catgcaatat taaaccatgc 35835 tagcctggcg aacaggtggg taaatcactc tttccagcac caggcaggct acggggtctc 35895 cggcgcgacc ctcgtagaag ctgtcgccat gattgaaaag catcaccgag agaccttccc 35955 ggtggccggc atggatgatt cgagaagaag catacactcc gggaacattg gcatccgtga 36015 gtgaaaaaaa gcgacctata aagcctcggg gcactacaat gctcaatctc aattccagca 36075 aagccacccc atgcggatgg agcacaaaat tggcaggtgc gtaaaaaatg taattactcc 36135 cctcctgcac aggcagcaaa gcccccgctc cctccagaaa cacatacaaa gcctcagcgt 36195 ccatagctta ccgagcacgg caggcgcaag agtcagagaa aaggctgagc tctaacctga 36255 ctgcccgctc ctgtgctcaa tatatagccc taacctacac tgacgtaaag gccaaagtct 36315 aaaaataccc gccaaaatga cacacacgcc cagcacacgc ccagaaaccg gtgacacact 36375 caaaaaaata cgtgcgcttc ctcaaacgcc caaaccggcg tcatttccgg gttcccacgc 36435 tacgtcaccg ctcagcgact ttcaaattcc gtcgaccgtt aaaaacgtca ctcgccccgc 36495 ccctaacggt cgcccttctc tcggccaatc accttcctcc cttcccaaat tcaaacgcct 36555 catttgcata ttaacgcgca caaaaagttt gaggtatatt attgatgatg atcgtttaaa 36615 ctatgcggtg tgaaataccg cacagatgcg taaggagaaa ataccgcatc aggcgctctt 36675 ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag 36735 ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca 36795 tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt 36855 tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc 36915 gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct 36975 ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg 37035 tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca 37095 agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact 37155 atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta 37215 acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta 37275 actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct 37335 tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt 37395 tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga 37455 tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca 37515 tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat 37575 caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg 37635 cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt 37695 agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag 37755 acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc 37815 gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag 37875 ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctgcaggca 37935 tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa 37995 ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga 38055 tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata 38115 attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca 38175 agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaacacggg 38235 ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg 38295 ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg 38355 cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag 38415 gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac 38475 tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca 38535 tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag 38595 tgccacctga cgtctaagaa accattatta tcatgacatt aacctataaa aataggcgta 38655 tcacgaggcc ctttcgtctt caagaattgt ttaaactacc atcat 38700 <210> 379 <211> 95 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 379 Pro Ala Ala Pro Glu His Pro Arg His Ala Arg Gly Ala Ser Leu Ala 1 5 10 15 Ala Gln Gly Gln Ala His Gly Thr Gln Gly His Ala Gln Gly Gly Gln 20 25 30 Thr Arg Gly Leu Arg Arg Gln Arg Arg Gln Asp Pro Glu Thr Arg Gly 35 40 45 His Gly Gly Gly Ser Gly His Arg Gln His Val Pro Pro Ala Ala Arg 50 55 60 Glu Arg Val Leu Gly Ala Arg Arg Arg His Arg Cys Ala Arg Ala Arg 65 70 75 80 Ala His Pro Pro Pro Ser His Leu Lys Met Phe Thr Ser Arg Cys 85 90 95 <210> 380 <211> 348 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 380 Cys Val Pro Ala Ala Arg Met Ser Lys Arg Lys Phe Lys Glu Glu Met 1 5 10 15 Leu Gln Val Ile Ala Pro Glu Ile Tyr Gly Pro Ala Val Val Lys Glu 20 25 30 Glu Arg Lys Pro Arg Lys Ile Lys Arg Val Lys Lys Asp Lys Lys Glu 35 40 45 Glu Glu Ser Asp Val Asp Gly Leu Val Glu Phe Val Arg Glu Phe Ala 50 55 60 Pro Arg Arg Arg Val Gln Trp Arg Gly Arg Lys Val Arg Pro Val Leu 65 70 75 80 Arg Pro Gly Thr Thr Val Val Phe Thr Pro Gly Glu Arg Ser Gly Thr 85 90 95 Ala Ser Lys Arg Ser Tyr Asp Glu Val Tyr Gly Asp Glu Asp Ile Leu 100 105 110 Glu Gln Ala Ala Glu Arg Leu Gly Glu Phe Ala Tyr Gly Lys Arg Ser 115 120 125 Arg Ser Ala Pro Lys Glu Glu Ala Val Ser Ile Pro Leu Asp His Gly 130 135 140 Asn Pro Thr Pro Ser Leu Lys Pro Val Thr Leu Gln Gln Val Leu Pro 145 150 155 160 Thr Ala Ala Pro Arg Arg Gly Phe Lys Arg Glu Gly Glu Asp Leu Tyr 165 170 175 Pro Thr Met Gln Leu Met Val Pro Lys Arg Gln Lys Leu Glu Asp Val 180 185 190 Leu Glu Thr Met Lys Val Asp Pro Asp Val Gln Pro Glu Val Lys Val 195 200 205 Arg Pro Ile Lys Gln Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp 210 215 220 Ile Lys Ile Pro Thr Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys 225 230 235 240 Pro Ser Thr Ser Thr Met Glu Val Gln Thr Asp Pro Trp Met Pro Ser 245 250 255 Ala Thr Ser Arg Arg Pro Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu 260 265 270 Met Pro Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr 275 280 285 Arg Gly Thr Arg Phe Tyr Arg Gly His Thr Ser Arg Arg Arg Lys Thr 290 295 300 Thr Thr Arg Arg Arg Arg Arg Arg Thr Thr Ala Ala Ala Ser Thr Pro 305 310 315 320 Ala Ala Leu Val Arg Arg Val Tyr Arg Arg Gly Arg Ala Pro Leu Thr 325 330 335 Leu Pro Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 340 345 <210> 381 <211> 59 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 381 Thr Phe Ala Cys Phe Ala Asp Gln Trp Pro Ser His Ala Ala Ser Ala 1 5 10 15 Phe Pro Leu Arg Ala Thr Glu Glu Glu Asn Arg Ala Val Glu Gly Trp 20 25 30 Arg Gly Thr Gly Cys Val Ala Thr Thr Thr Gly Gly Gly Ala Pro Ser 35 40 45 Ala Ser Gly Trp Gly Glu Ala Ser Cys Pro Arg 50 55 <210> 382 <211> 27 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 382 Ser Pro Ser Ser Pro Arg Arg Ser Gly Arg Ser Pro Ala Leu Leu Pro 1 5 10 15 Trp Arg Cys Arg Pro Leu Ser Ala Thr Glu Thr 20 25 <210> 383 <211> 801 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 383 Met Glu Thr Gln Pro Ser Pro Thr Ser Pro Ser Ala Pro Thr Thr Ala 1 5 10 15 Asp Glu Lys Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro Pro Ser Pro 20 25 30 Ala Thr Ser Asp Ala Ala Ala Val Pro Asp Met Gln Glu Met Glu Glu 35 40 45 Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu Glu 50 55 60 Glu Leu Ala Val Arg Phe Gln Ser Ser Ser Gln Glu Asp Lys Glu Gln 65 70 75 80 Pro Glu Gln Glu Ala Glu Asn Glu Gln Ser Gln Ala Gly Leu Glu His 85 90 95 Asp Gly Asp Tyr Leu His Leu Ser Gly Glu Glu Asp Ala Leu Ile Lys 100 105 110 His Leu Ala Arg Gln Ala Ile Ile Val Lys Asp Ala Leu Leu Asp Arg 115 120 125 Thr Glu Val Pro Leu Ser Val Glu Glu Leu Ser Arg Ala Tyr Glu Leu 130 135 140 Asn Leu Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr 145 150 155 160 Cys Glu Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro 165 170 175 Glu Ala Leu Ala Thr Tyr His Ile Phe Phe Lys Asn Gln Lys Ile Pro 180 185 190 Val Ser Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Phe Asn Leu 195 200 205 Gly Pro Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro 210 215 220 Lys Ile Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala 225 230 235 240 Leu Gln Gly Glu Gly Gly Glu His Glu His His Ser Ala Leu Val Glu 245 250 255 Leu Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu 260 265 270 Leu Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met 275 280 285 Ser Ala Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Ile Ser 290 295 300 Glu Asp Glu Gly Met Gln Asp Ser Glu Asp Gly Lys Pro Val Val Ser 305 310 315 320 Asp Glu Gln Leu Ala Arg Trp Leu Gly Pro Asn Ala Ser Pro Gln Ser 325 330 335 Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr Val 340 345 350 Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu Arg 355 360 365 Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val Arg 370 375 380 Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr 385 390 395 400 Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr 405 410 415 Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr 420 425 430 Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln Gln 435 440 445 Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys 450 455 460 Asn Leu Lys Gly Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser 465 470 475 480 Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg 485 490 495 Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg 500 505 510 Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala 515 520 525 Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro 530 535 540 Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala Tyr 545 550 555 560 His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu Cys 565 570 575 His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys Asn 580 585 590 Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln 595 600 605 Gly Pro Ser Asp Asp Gly Glu Gly Ala Lys Gly Gly Leu Lys Leu Thr 610 615 620 Pro Gly Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp 625 630 635 640 Tyr His Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro 645 650 655 Lys Ala Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala 660 665 670 Gln Leu Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys 675 680 685 Gly Arg Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro 690 695 700 Gly Phe Pro Gln Asp Ala Pro Arg Lys Gln Glu Ala Glu Ser Gly Ala 705 710 715 720 Ala Ala Arg Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Gln Ser Gly 725 730 735 Arg Gly Gly Asp Gly Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly 740 745 750 Gln Pro Ala Arg Gln Ser Gly Gly Arg Arg Gly Gly Gly Arg Gly Gly 755 760 765 Arg Ser Ser Arg Arg Gln Thr Val Val Leu Gly Gly Gly Glu Ser Lys 770 775 780 Gln His Gly Tyr His Leu Arg Ser Gly Ser Gly Ser Arg Ser Ala Pro 785 790 795 800 Gln <210> 384 <211> 212 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 384 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Asn Cys Gly Val Ser Ala Ser Ile Asn 20 25 30 Gln Ser Leu Thr Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys 35 40 45 Lys Pro His Lys Lys Tyr Leu Thr Trp Leu Tyr Gln Gly Ser Pro Ile 50 55 60 Ala Val Val Asn His Cys Asp Asp Asp Gly Val Leu Leu Asn Gly Pro 65 70 75 80 Ala Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Leu Leu Phe Arg 85 90 95 Pro Phe Leu Pro Gly Ile Tyr Gln Cys Ile Ser Gly Pro Cys His His 100 105 110 Thr Phe His Leu Ile Pro Asn Thr Thr Ser Ser Pro Ala Pro Leu Pro 115 120 125 Thr Asn Asn Gln Thr Asn His Gln Arg His Arg Arg Asp Leu Ser Ser 130 135 140 Asp Ser Asn Thr Thr Thr Gly Gly Glu Leu Arg Gly Thr Lys Lys Ser 145 150 155 160 Ser Pro Gly Ile Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala 165 170 175 Leu Gly Leu Val Ala Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu 180 185 190 Pro Cys Cys Ser Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp 195 200 205 Gly Arg Ser Pro 210 <210> 385 <211> 149 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 385 Met Ile Ser Met Arg Ala Leu Leu Leu Leu Leu Ala Leu Leu Leu Ala 1 5 10 15 Pro Leu Ala Ala Pro Leu Ser Leu Lys Ser Pro Thr Gln Ser Pro Glu 20 25 30 Glu Val Arg Lys Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Ser Cys 35 40 45 Tyr Lys Leu Lys Ser Glu Met His Pro Ser Trp Ile Met Ile Val Gly 50 55 60 Ile Val Asn Ile Leu Ala Cys Thr Leu Phe Ser Phe Val Ile Tyr Pro 65 70 75 80 Arg Phe Asp Phe Gly Trp Asn Ala Pro Glu Ala Leu Trp Leu Pro Pro 85 90 95 Asp Pro Asp Thr Pro Pro Gln Gln Gln Gln Asn Gln Ala Gln Ala His 100 105 110 Ala Pro Pro Gln Pro Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu 115 120 125 Ala Glu Pro Gln Arg Ala Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu 130 135 140 Thr Gly Gly Asp Asp 145 <210> 386 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 386 Gln Arg Gly Lys Gly Ala Gly Gly Trp Tyr Gly 1 5 10 <210> 387 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 387 Trp Arg Asp Asp Ala Asn Arg Val Leu Asp Arg Val Met Met Glu Leu 1 5 10 15 Phe Pro Asp Ile Phe Val Leu His Glu Ala Glu Pro Gly Thr Gly Thr 20 25 30 Ala His Arg Ser Pro Ala Thr Val Ser Ala Leu Arg Ala Leu Gly Val 35 40 45 Glu Val Ile Glu Gln Pro Leu Pro Gln Ser Val Gln Tyr Leu Leu Ser 50 55 60 Leu Leu Gly Asp Glu Asn Pro Ile Arg Ser Asp Gly Ser Asp His Ile 65 70 75 80 Gly His Gly Gly Met Gly Gln Thr Gln Pro Asp Asp Ala Ile Leu Leu 85 90 95 Gly Phe Gly Asp Gly Gly Arg Gly Lys Asn Arg Lys Asn His 100 105 110 <210> 388 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 388 Phe Gln Glu Ile Leu Leu Leu Val His Leu Gln Gln Ile Asn Asn Gly 1 5 10 15 Asn Ile Lys Ile Ser Ala Ala Ile Pro Lys Leu Leu Pro Gln Gln 20 25 30 <210> 389 <211> 79 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 389 Leu Tyr Val Ile Phe His Ile Ile Ser Glu Ile Phe Ser His Arg Ala 1 5 10 15 Ala Arg Asn Lys Ser Arg Ala Ser His Ile Thr Asp Lys Ala Lys Ser 20 25 30 Ser Pro Val Ser Ile Ala Lys Cys Lys Ile Glu Ile Ser Met Leu Ala 35 40 45 Arg Pro Cys Asp Ile Phe Gln Ile Thr Gly Gln Lys Ile Arg Gln Ala 50 55 60 Ile Phe Lys Lys Ile Asn Lys Arg Lys Val Val Gln Val Gln Val 65 70 75 <210> 390 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 390 Ser Leu Arg Asn Asn Asp Gly Ile Ser Ala Arg Ser Ala Phe Gln His 1 5 10 15 <210> 391 <211> 5308 <212> DNA <213> Artificial Sequence <220> <223> p2311 - vector based on HIV <220> <221> mutation <222> (1)..(1) <223> 8 bp deletion - TTCGCGTT <220> <221> enhancer <222> (108)..(368) <223> enhancer <220> <221> misc_feature <222> (369)..(596) <223> CMV promoter <220> <221> TATA_signal <222> (570)..(573) <223> TATA <220> <221> CDS <222> (692)..(1783) <223> Gag short <220> <221> primer_bind <222> (1772)..(1801) <223> BG166R <220> <221> polyA_signal <222> (1936)..(2138) <223> BGH-PolyA (bovine growth hormone (bGH) polyadenylation signal) <220> <221> mutation <222> (2210)..(2210) <223> C deletion <220> <221> misc_feature <222> (2436)..(2460) <223> I-CeuI recognition sequence <220> <221> mutation <222> (2461)..(2461) <223> A deletion <220> <221> CDS <222> (2913)..(3728) <223> Kanamycin-r <220> <221> misc_feature <222> (4402)..(5045) <223> ColE1-Ori complement (4402..5045) <220> <221> misc_feature <222> (5291)..(5291) <223> PI-SceI recognition site <400> 391 gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc 60 catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca 120 acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga 180 ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc 240 aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct 300 ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat 360 tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc 420 ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt 480 ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa 540 tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc 600 agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat 660 ccagcctccg cgggcgcgcg tcgacagaga g atg ggt gcg aga gcg tca gta 712 Met Gly Ala Arg Ala Ser Val 1 5 tta agc ggg gga gaa tta gat cga tgg gaa aaa att cgg tta agg cca 760 Leu Ser Gly Gly Glu Leu Asp Arg Trp Glu Lys Ile Arg Leu Arg Pro 10 15 20 ggg gga aag aag aag tac aag cta aag cac atc gta tgg gca agc agg 808 Gly Gly Lys Lys Lys Tyr Lys Leu Lys His Ile Val Trp Ala Ser Arg 25 30 35 gag cta gaa cga ttc gca gtt aat cct ggc ctg tta gaa aca tca gaa 856 Glu Leu Glu Arg Phe Ala Val Asn Pro Gly Leu Leu Glu Thr Ser Glu 40 45 50 55 ggc tgt aga caa ata ctg gga cag cta caa cca tcc ctt cag aca gga 904 Gly Cys Arg Gln Ile Leu Gly Gln Leu Gln Pro Ser Leu Gln Thr Gly 60 65 70 tca gag gag ctt cga tca cta tac aac aca gta gca acc ctc tat tgt 952 Ser Glu Glu Leu Arg Ser Leu Tyr Asn Thr Val Ala Thr Leu Tyr Cys 75 80 85 gtg cac cag cgg atc gag atc aag gac acc aag gaa gct tta gac aag 1000 Val His Gln Arg Ile Glu Ile Lys Asp Thr Lys Glu Ala Leu Asp Lys 90 95 100 ata gag gaa gag caa aac aag tcc aag aag aag gcc cag cag gca gca 1048 Ile Glu Glu Glu Gln Asn Lys Ser Lys Lys Lys Ala Gln Gln Ala Ala 105 110 115 gct gac aca gga cac agc aat cag gtc agc caa aat tac cct ata gtg 1096 Ala Asp Thr Gly His Ser Asn Gln Val Ser Gln Asn Tyr Pro Ile Val 120 125 130 135 cag aac atc cag ggg caa atg gta cat cag gcc ata tca cct aga act 1144 Gln Asn Ile Gln Gly Gln Met Val His Gln Ala Ile Ser Pro Arg Thr 140 145 150 tta aat gca tgg gta aaa gta gta gaa gag aag gct ttc agc cca gaa 1192 Leu Asn Ala Trp Val Lys Val Val Glu Glu Lys Ala Phe Ser Pro Glu 155 160 165 gtg ata ccc atg ttt tca gca tta tca gaa gga gcc acc cca cag gac 1240 Val Ile Pro Met Phe Ser Ala Leu Ser Glu Gly Ala Thr Pro Gln Asp 170 175 180 ctg aac acg atg ttg aac acc gtg ggg gga cat caa gca gcc atg caa 1288 Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln Ala Ala Met Gln 185 190 195 atg tta aaa gag acc atc aat gag gaa gct gca gaa tgg gat aga gtg 1336 Met Leu Lys Glu Thr Ile Asn Glu Glu Ala Ala Glu Trp Asp Arg Val 200 205 210 215 cat cca gtg cat gca ggg cct att gca cca ggc cag atg aga gaa cca 1384 His Pro Val His Ala Gly Pro Ile Ala Pro Gly Gln Met Arg Glu Pro 220 225 230 agg gga agt gac ata gca gga act act agt acc ctt cag gaa caa ata 1432 Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Thr Leu Gln Glu Gln Ile 235 240 245 gga tgg atg aca aat aat cca cct atc cca gta gga gag atc tac aag 1480 Gly Trp Met Thr Asn Asn Pro Pro Ile Pro Val Gly Glu Ile Tyr Lys 250 255 260 agg tgg ata atc ctg gga ttg aac aag atc gtg agg atg tat agc cct 1528 Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg Met Tyr Ser Pro 265 270 275 acc agc att ctg gac ata aga caa gga cca aaa gaa ccc ttt aga gac 1576 Thr Ser Ile Leu Asp Ile Arg Gln Gly Pro Lys Glu Pro Phe Arg Asp 280 285 290 295 tat gta gac cgg ttc tat aaa act cta aga gct gag caa gct tca cag 1624 Tyr Val Asp Arg Phe Tyr Lys Thr Leu Arg Ala Glu Gln Ala Ser Gln 300 305 310 gag gta aaa aat tgg atg aca gaa acc ttg ttg gtc caa aat gcg aac 1672 Glu Val Lys Asn Trp Met Thr Glu Thr Leu Leu Val Gln Asn Ala Asn 315 320 325 cca gat tgt aag acc atc ctg aag gct ctc ggc cca gcg gct aca cta 1720 Pro Asp Cys Lys Thr Ile Leu Lys Ala Leu Gly Pro Ala Ala Thr Leu 330 335 340 gaa gaa atg atg aca gca tgt cag gga gta gga gga ccc ggc cat aag 1768 Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly Pro Gly His Lys 345 350 355 gca aga gtt ttg tag ggatccacta gttctagact cgaggggggg cccggtacct 1823 Ala Arg Val Leu 360 ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg 1883 ggactggaag ggctaattca ctcccaaaga agacaagata aaccgctgat cagcctcgac 1943 tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct 2003 ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct 2063 gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg 2123 ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag 2183 aaccagcaga tctgcagatc tgaattgcgt atatctggcc cgtacatcgc gaagcagcgc 2243 aaaacgccta accctaagca gattcttcat gcaattgtcg gtcaagcctt gccttgttgt 2303 agcttaaatt ttgctcgcgc actactcagc gacctccaac acacaagcag ggagcagata 2363 ctggcttaac tatgcggcat cagagcagat tgtactgaga gtgcaccata ggggatcggg 2423 agatctgagc tttcgctacc ttaggaccgt tatagttacg tcaggtggca cttttcgggg 2483 aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct 2543 catgagacaa taaccctgat aaatgcttca ataatctagc gctgaggtct gcctcgtgaa 2603 gaaggtgttg ctgactcata ccaggcctga atcgccccat catccagcca gaaagtgagg 2663 gagccacggt tgatgagagc tttgttgtag gtggaccagt tggtgatttt gaacttttgc 2723 tttgccacgg aacggtctgc gttgtcggga agatgcgtga tctgatcctt caactcagca 2783 aaagttcgat ttattcaaca aagccacgtt gtgtctcaaa atctctgatg ttacattgca 2843 caagataaaa atatatcatc atgaacaata aaactgtctg cttacataaa cagtaataca 2903 aggggtgtt atg agc cat att caa cgg gaa acg tct tgc tcg agg ccg cga 2954 Met Ser His Ile Gln Arg Glu Thr Ser Cys Ser Arg Pro Arg 365 370 375 tta aat tcc aac atg gat gct gat tta tat ggg tat aaa tgg gct cgc 3002 Leu Asn Ser Asn Met Asp Ala Asp Leu Tyr Gly Tyr Lys Trp Ala Arg 380 385 390 gat aat gtc ggg caa tca ggt gcg aca atc tat cga ttg tat ggg aag 3050 Asp Asn Val Gly Gln Ser Gly Ala Thr Ile Tyr Arg Leu Tyr Gly Lys 395 400 405 ccc gat gcg cca gag ttg ttt ctg aaa cat ggc aaa ggt agc gtt gcc 3098 Pro Asp Ala Pro Glu Leu Phe Leu Lys His Gly Lys Gly Ser Val Ala 410 415 420 425 aat gat gtt aca gat gag atg gtc aga cta aac tgg ctg acg gaa ttt 3146 Asn Asp Val Thr Asp Glu Met Val Arg Leu Asn Trp Leu Thr Glu Phe 430 435 440 atg cct ctt ccg acc atc aag cat ttt atc cgt act cct gat gat gca 3194 Met Pro Leu Pro Thr Ile Lys His Phe Ile Arg Thr Pro Asp Asp Ala 445 450 455 tgg tta ctc acc act gcg atc ccc ggg aaa aca gca ttc cag gta tta 3242 Trp Leu Leu Thr Thr Ala Ile Pro Gly Lys Thr Ala Phe Gln Val Leu 460 465 470 gaa gaa tat cct gat tca ggt gaa aat att gtt gat gcg ctg gca gtg 3290 Glu Glu Tyr Pro Asp Ser Gly Glu Asn Ile Val Asp Ala Leu Ala Val 475 480 485 ttc ctg cgc cgg ttg cat tcg att cct gtt tgt aat tgt cct ttt aac 3338 Phe Leu Arg Arg Leu His Ser Ile Pro Val Cys Asn Cys Pro Phe Asn 490 495 500 505 agc gat cgc gta ttt cgt ctc gct cag gcg caa tca cga atg aat aac 3386 Ser Asp Arg Val Phe Arg Leu Ala Gln Ala Gln Ser Arg Met Asn Asn 510 515 520 ggt ttg gtt gat gcg agt gat ttt gat gac gag cgt aat ggc tgg cct 3434 Gly Leu Val Asp Ala Ser Asp Phe Asp Asp Glu Arg Asn Gly Trp Pro 525 530 535 gtt gaa caa gtc tgg aaa gaa atg cat aag ctt ttg cca ttc tca ccg 3482 Val Glu Gln Val Trp Lys Glu Met His Lys Leu Leu Pro Phe Ser Pro 540 545 550 gat tca gtc gtc act cat ggt gat ttc tca ctt gat aac ctt att ttt 3530 Asp Ser Val Val Thr His Gly Asp Phe Ser Leu Asp Asn Leu Ile Phe 555 560 565 gac gag ggg aaa tta ata ggt tgt att gat gtt gga cga gtc gga atc 3578 Asp Glu Gly Lys Leu Ile Gly Cys Ile Asp Val Gly Arg Val Gly Ile 570 575 580 585 gca gac cga tac cag gat ctt gcc atc cta tgg aac tgc ctc ggt gag 3626 Ala Asp Arg Tyr Gln Asp Leu Ala Ile Leu Trp Asn Cys Leu Gly Glu 590 595 600 ttt tct cct tca tta cag aaa cgg ctt ttt caa aaa tat ggt att gat 3674 Phe Ser Pro Ser Leu Gln Lys Arg Leu Phe Gln Lys Tyr Gly Ile Asp 605 610 615 aat cct gat atg aat aaa ttg cag ttt cat ttg atg ctc gat gag ttt 3722 Asn Pro Asp Met Asn Lys Leu Gln Phe His Leu Met Leu Asp Glu Phe 620 625 630 ttc taa tcagaattgg ttaattggtt gtaacactgg cagagcatta cgctgacttg 3778 Phe acgggacggc ggctttgttg aataaatcga acttttgctg agttgaagga tcagatcacg 3838 catcttcccg acaacgcaga ccgttccgtg gcaaagcaaa agttcaaaat caccaactgg 3898 tccacctaca acaaagctct catcaaccgt ggctccctca ctttctggct ggatgatggg 3958 gcgattcagg cctggtatga gtcagcaaca ccttcttcac gaggcagacc tcagcgctca 4018 aagatgcagg ggtaaaagct aaccgcatct ttaccgacaa ggcatccggc agttcaacag 4078 atcgggaagg gctggatttg ctgaggatga aggtggagga aggtgatgtc attctggtga 4138 agaagctcga ccgtcttggc cgcgacaccg ccgacatgat ccaactgata aaagagtttg 4198 atgctcaggg tgtagcggtt cggtttattg acgacgggat cagtaccgac ggtgatatgg 4258 ggcaaatggt ggtcaccatc ctgtcggctg tggcacaggc tgaacgccgg aggatcaaaa 4318 ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt 4378 cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt 4438 ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt 4498 tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga 4558 taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag 4618 caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata 4678 agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg 4738 gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga 4798 gatacctaca gcgtgagcat tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca 4858 ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa 4918 acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt 4978 tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac 5038 ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt 5098 ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga 5158 ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc 5218 tccccgcgcg ttggccgatt cattaatgca gacccataat acccataatg ccatttcatt 5278 acctctttct ccgcacccga catagatgaa 5308 <210> 392 <211> 363 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 392 Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 1 5 10 15 Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 20 25 30 His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 35 40 45 Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 50 55 60 Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 65 70 75 80 Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 85 90 95 Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 100 105 110 Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val 115 120 125 Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 130 135 140 Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 145 150 155 160 Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 165 170 175 Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 180 185 190 Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 195 200 205 Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 210 215 220 Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 225 230 235 240 Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 245 250 255 Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 260 265 270 Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 275 280 285 Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 290 295 300 Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 305 310 315 320 Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 325 330 335 Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 340 345 350 Val Gly Gly Pro Gly His Lys Ala Arg Val Leu 355 360 <210> 393 <211> 271 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 393 Met Ser His Ile Gln Arg Glu Thr Ser Cys Ser Arg Pro Arg Leu Asn 1 5 10 15 Ser Asn Met Asp Ala Asp Leu Tyr Gly Tyr Lys Trp Ala Arg Asp Asn 20 25 30 Val Gly Gln Ser Gly Ala Thr Ile Tyr Arg Leu Tyr Gly Lys Pro Asp 35 40 45 Ala Pro Glu Leu Phe Leu Lys His Gly Lys Gly Ser Val Ala Asn Asp 50 55 60 Val Thr Asp Glu Met Val Arg Leu Asn Trp Leu Thr Glu Phe Met Pro 65 70 75 80 Leu Pro Thr Ile Lys His Phe Ile Arg Thr Pro Asp Asp Ala Trp Leu 85 90 95 Leu Thr Thr Ala Ile Pro Gly Lys Thr Ala Phe Gln Val Leu Glu Glu 100 105 110 Tyr Pro Asp Ser Gly Glu Asn Ile Val Asp Ala Leu Ala Val Phe Leu 115 120 125 Arg Arg Leu His Ser Ile Pro Val Cys Asn Cys Pro Phe Asn Ser Asp 130 135 140 Arg Val Phe Arg Leu Ala Gln Ala Gln Ser Arg Met Asn Asn Gly Leu 145 150 155 160 Val Asp Ala Ser Asp Phe Asp Asp Glu Arg Asn Gly Trp Pro Val Glu 165 170 175 Gln Val Trp Lys Glu Met His Lys Leu Leu Pro Phe Ser Pro Asp Ser 180 185 190 Val Val Thr His Gly Asp Phe Ser Leu Asp Asn Leu Ile Phe Asp Glu 195 200 205 Gly Lys Leu Ile Gly Cys Ile Asp Val Gly Arg Val Gly Ile Ala Asp 210 215 220 Arg Tyr Gln Asp Leu Ala Ile Leu Trp Asn Cys Leu Gly Glu Phe Ser 225 230 235 240 Pro Ser Leu Gln Lys Arg Leu Phe Gln Lys Tyr Gly Ile Asp Asn Pro 245 250 255 Asp Met Asn Lys Leu Gln Phe His Leu Met Leu Asp Glu Phe Phe 260 265 270 <210> 394 <211> 5309 <212> DNA <213> Artificial Sequence <220> <223> p0621 - vector based on HIV <220> <221> enhancer <222> (345)..(605) <223> enhancer <220> <221> misc_feature <222> (606)..(833) <223> CMV promoter <220> <221> TATA_signal <222> (807)..(810) <223> TATA <220> <221> CDS <222> (929)..(2020) <223> Gag short <220> <221> polyA_signal <222> (2173)..(2375) <223> BGH-PolyA (bovine growth hormone (bGH) polyadenylation signal) <220> <221> misc_feature <222> (2462)..(2462) <223> PI-SceI recognition site <220> <221> misc_feature <222> (2708)..(3351) <223> ColE1-Ori <220> <221> CDS <222> (4025)..(4840) <223> Kanamycin-r complement (4025..4840) <220> <221> misc_feature <222> (5298)..(8) <223> I-CeuI recognition sequence <400> 394 ggtagcgaaa gctcagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg 60 atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt 120 gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc 180 tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac 240 attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat 300 atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg 360 acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt 420 tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag 480 tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc 540 attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag 600 tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt 660 ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc 720 accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg 780 gcggtaggcg tgtacggtgg gaggtctata taagcagagc tcgtttagtg aaccgtcaga 840 tcgcctggag acgccatcca cgctgttttg acctccatag aagacaccgg gaccgatcca 900 gcctccgcgg gcgcgcgtcg acagagag atg ggt gcg aga gcg tca gta tta 952 Met Gly Ala Arg Ala Ser Val Leu 1 5 agc ggg gga gaa tta gat cga tgg gaa aaa att cgg tta agg cca ggg 1000 Ser Gly Gly Glu Leu Asp Arg Trp Glu Lys Ile Arg Leu Arg Pro Gly 10 15 20 gga aag aag aag tac aag cta aag cac atc gta tgg gca agc agg gag 1048 Gly Lys Lys Lys Tyr Lys Leu Lys His Ile Val Trp Ala Ser Arg Glu 25 30 35 40 cta gaa cga ttc gca gtt aat cct ggc ctg tta gaa aca tca gaa ggc 1096 Leu Glu Arg Phe Ala Val Asn Pro Gly Leu Leu Glu Thr Ser Glu Gly 45 50 55 tgt aga caa ata ctg gga cag cta caa cca tcc ctt cag aca gga tca 1144 Cys Arg Gln Ile Leu Gly Gln Leu Gln Pro Ser Leu Gln Thr Gly Ser 60 65 70 gag gag ctt cga tca cta tac aac aca gta gca acc ctc tat tgt gtg 1192 Glu Glu Leu Arg Ser Leu Tyr Asn Thr Val Ala Thr Leu Tyr Cys Val 75 80 85 cac cag cgg atc gag atc aag gac acc aag gaa gct tta gac aag ata 1240 His Gln Arg Ile Glu Ile Lys Asp Thr Lys Glu Ala Leu Asp Lys Ile 90 95 100 gag gaa gag caa aac aag tcc aag aag aag gcc cag cag gca gca gct 1288 Glu Glu Glu Gln Asn Lys Ser Lys Lys Lys Ala Gln Gln Ala Ala Ala 105 110 115 120 gac aca gga cac agc aat cag gtc agc caa aat tac cct ata gtg cag 1336 Asp Thr Gly His Ser Asn Gln Val Ser Gln Asn Tyr Pro Ile Val Gln 125 130 135 aac atc cag ggg caa atg gta cat cag gcc ata tca cct aga act tta 1384 Asn Ile Gln Gly Gln Met Val His Gln Ala Ile Ser Pro Arg Thr Leu 140 145 150 aat gca tgg gta aaa gta gta gaa gag aag gct ttc agc cca gaa gtg 1432 Asn Ala Trp Val Lys Val Val Glu Glu Lys Ala Phe Ser Pro Glu Val 155 160 165 ata ccc atg ttt tca gca tta tca gaa gga gcc acc cca cag gac ctg 1480 Ile Pro Met Phe Ser Ala Leu Ser Glu Gly Ala Thr Pro Gln Asp Leu 170 175 180 aac acg atg ttg aac acc gtg ggg gga cat caa gca gcc atg caa atg 1528 Asn Thr Met Leu Asn Thr Val Gly Gly His Gln Ala Ala Met Gln Met 185 190 195 200 tta aaa gag acc atc aat gag gaa gct gca gaa tgg gat aga gtg cat 1576 Leu Lys Glu Thr Ile Asn Glu Glu Ala Ala Glu Trp Asp Arg Val His 205 210 215 cca gtg cat gca ggg cct att gca cca ggc cag atg aga gaa cca agg 1624 Pro Val His Ala Gly Pro Ile Ala Pro Gly Gln Met Arg Glu Pro Arg 220 225 230 gga agt gac ata gca gga act act agt acc ctt cag gaa caa ata gga 1672 Gly Ser Asp Ile Ala Gly Thr Thr Ser Thr Leu Gln Glu Gln Ile Gly 235 240 245 tgg atg aca aat aat cca cct atc cca gta gga gag atc tac aag agg 1720 Trp Met Thr Asn Asn Pro Pro Ile Pro Val Gly Glu Ile Tyr Lys Arg 250 255 260 tgg ata atc ctg gga ttg aac aag atc gtg agg atg tat agc cct acc 1768 Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg Met Tyr Ser Pro Thr 265 270 275 280 agc att ctg gac ata aga caa gga cca aaa gaa ccc ttt aga gac tat 1816 Ser Ile Leu Asp Ile Arg Gln Gly Pro Lys Glu Pro Phe Arg Asp Tyr 285 290 295 gta gac cgg ttc tat aaa act cta aga gct gag caa gct tca cag gag 1864 Val Asp Arg Phe Tyr Lys Thr Leu Arg Ala Glu Gln Ala Ser Gln Glu 300 305 310 gta aaa aat tgg atg aca gaa acc ttg ttg gtc caa aat gcg aac cca 1912 Val Lys Asn Trp Met Thr Glu Thr Leu Leu Val Gln Asn Ala Asn Pro 315 320 325 gat tgt aag acc atc ctg aag gct ctc ggc cca gcg gct aca cta gaa 1960 Asp Cys Lys Thr Ile Leu Lys Ala Leu Gly Pro Ala Ala Thr Leu Glu 330 335 340 gaa atg atg aca gca tgt cag gga gta gga gga ccc ggc cat aag gca 2008 Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly Pro Gly His Lys Ala 345 350 355 360 aga gtt ttg tag ggatccacta gttctagact cgaggggggg cccggtacct 2060 Arg Val Leu ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg 2120 ggactggaag ggctaattca ctcccaaaga agacaagata aaccgctgat cagcctcgac 2180 tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct 2240 ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct 2300 gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg 2360 ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag 2420 aaccagcaga tctgcagatc tgaattcatc tatgtcgggt gcggagaaag aggtaatgaa 2480 atggcattat gggtattatg ggtctgcatt aatgaatcgg ccaacgcgcg gggagaggcg 2540 gtttgcgtat tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc 2600 ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag 2660 gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa 2720 aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc 2780 gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc 2840 ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg 2900 cctttctccc ttcgggaagc gtggcgcttt ctcaatgctc acgctgtagg tatctcagtt 2960 cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc 3020 gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc 3080 cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag 3140 agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg 3200 ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa 3260 ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag 3320 gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact 3380 cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttga 3440 tcctccggcg ttcagcctgt gccacagccg acaggatggt gaccaccatt tgccccatat 3500 caccgtcggt actgatcccg tcgtcaataa accgaaccgc tacaccctga gcatcaaact 3560 cttttatcag ttggatcatg tcggcggtgt cgcggccaag acggtcgagc ttcttcacca 3620 gaatgacatc accttcctcc accttcatcc tcagcaaatc cagcccttcc cgatctgttg 3680 aactgccgga tgccttgtcg gtaaagatgc ggttagcttt tacccctgca tctttgagcg 3740 ctgaggtctg cctcgtgaag aaggtgttgc tgactcatac caggcctgaa tcgccccatc 3800 atccagccag aaagtgaggg agccacggtt gatgagagct ttgttgtagg tggaccagtt 3860 ggtgattttg aacttttgct ttgccacgga acggtctgcg ttgtcgggaa gatgcgtgat 3920 ctgatccttc aactcagcaa aagttcgatt tattcaacaa agccgccgtc ccgtcaagtc 3980 agcgtaatgc tctgccagtg ttacaaccaa ttaaccaatt ctga tta gaa aaa ctc 4036 Leu Glu Lys Leu 365 atc gag cat caa atg aaa ctg caa ttt att cat atc agg att atc aat 4084 Ile Glu His Gln Met Lys Leu Gln Phe Ile His Ile Arg Ile Ile Asn 370 375 380 acc ata ttt ttg aaa aag ccg ttt ctg taa tga agg aga aaa ctc acc 4132 Thr Ile Phe Leu Lys Lys Pro Phe Leu Arg Arg Lys Leu Thr 385 390 395 gag gca gtt cca tag gat ggc aag atc ctg gta tcg gtc tgc gat tcc 4180 Glu Ala Val Pro Asp Gly Lys Ile Leu Val Ser Val Cys Asp Ser 400 405 410 gac tcg tcc aac atc aat aca acc tat taa ttt ccc ctc gtc aaa aat 4228 Asp Ser Ser Asn Ile Asn Thr Thr Tyr Phe Pro Leu Val Lys Asn 415 420 425 aag gtt atc aag tga gaa atc acc atg agt gac gac tga atc cgg tga 4276 Lys Val Ile Lys Glu Ile Thr Met Ser Asp Asp Ile Arg 430 435 440 gaa tgg caa aag ctt atg cat ttc ttt cca gac ttg ttc aac agg cca 4324 Glu Trp Gln Lys Leu Met His Phe Phe Pro Asp Leu Phe Asn Arg Pro 445 450 455 gcc att acg ctc gtc atc aaa atc act cgc atc aac caa acc gtt att 4372 Ala Ile Thr Leu Val Ile Lys Ile Thr Arg Ile Asn Gln Thr Val Ile 460 465 470 cat tcg tga ttg cgc ctg agc gag acg aaa tac gcg atc gct gtt aaa 4420 His Ser Leu Arg Leu Ser Glu Thr Lys Tyr Ala Ile Ala Val Lys 475 480 485 agg aca att aca aac agg aat cga atg caa ccg gcg cag gaa cac tgc 4468 Arg Thr Ile Thr Asn Arg Asn Arg Met Gln Pro Ala Gln Glu His Cys 490 495 500 cag cgc atc aac aat att ttc acc tga atc agg ata ttc ttc taa tac 4516 Gln Arg Ile Asn Asn Ile Phe Thr Ile Arg Ile Phe Phe Tyr 505 510 515 ctg gaa tgc tgt ttt ccc ggg gat cgc agt ggt gag taa cca tgc atc 4564 Leu Glu Cys Cys Phe Pro Gly Asp Arg Ser Gly Glu Pro Cys Ile 520 525 530 atc agg agt acg gat aaa atg ctt gat ggt cgg aag agg cat aaa ttc 4612 Ile Arg Ser Thr Asp Lys Met Leu Asp Gly Arg Lys Arg His Lys Phe 535 540 545 cgt cag cca gtt tag tct gac cat ctc atc tgt aac atc att ggc aac 4660 Arg Gln Pro Val Ser Asp His Leu Ile Cys Asn Ile Ile Gly Asn 550 555 560 gct acc ttt gcc atg ttt cag aaa caa ctc tgg cgc atc ggg ctt ccc 4708 Ala Thr Phe Ala Met Phe Gln Lys Gln Leu Trp Arg Ile Gly Leu Pro 565 570 575 ata caa tcg ata gat tgt cgc acc tga ttg ccc gac att atc gcg agc 4756 Ile Gln Ser Ile Asp Cys Arg Thr Leu Pro Asp Ile Ile Ala Ser 580 585 590 cca ttt ata ccc ata taa atc agc atc cat gtt gga att taa tcg cgg 4804 Pro Phe Ile Pro Ile Ile Ser Ile His Val Gly Ile Ser Arg 595 600 605 cct cga gca aga cgt ttc ccg ttg aat atg gct cat aacacccctt 4850 Pro Arg Ala Arg Arg Phe Pro Leu Asn Met Ala His 610 615 620 gtattactgt ttatgtaagc agacagtttt attgttcatg atgatatatt tttatcttgt 4910 gcaatgtaac atcagagatt ttgagacaca acgtggcttt gttgaataaa tcgaactttt 4970 gctgagttga aggatcagat cacgcatctt cccgacaacg cagaccgttc cgtggcaaag 5030 caaaagttca aaatcaccaa ctggtccacc tacaacaaag ctctcatcaa ccgtggctcc 5090 ctcactttct ggctggatga tggggcgatt caggcctggt atgagtcagc aacaccttct 5150 tcacgaggca gacctcagcg ctagattatt gaagcattta tcagggttat tgtctcatga 5210 gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc 5270 cccgaaaagt gccacctgac gtaactataa cggtcctaa 5309 <210> 395 <211> 363 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 395 Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 1 5 10 15 Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 20 25 30 His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 35 40 45 Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 50 55 60 Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 65 70 75 80 Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 85 90 95 Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 100 105 110 Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val 115 120 125 Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 130 135 140 Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 145 150 155 160 Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 165 170 175 Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 180 185 190 Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 195 200 205 Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 210 215 220 Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 225 230 235 240 Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 245 250 255 Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 260 265 270 Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 275 280 285 Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 290 295 300 Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 305 310 315 320 Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 325 330 335 Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 340 345 350 Val Gly Gly Pro Gly His Lys Ala Arg Val Leu 355 360 <210> 396 <211> 29 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 396 Leu Glu Lys Leu Ile Glu His Gln Met Lys Leu Gln Phe Ile His Ile 1 5 10 15 Arg Ile Ile Asn Thr Ile Phe Leu Lys Lys Pro Phe Leu 20 25 <210> 397 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 397 Arg Arg Lys Leu Thr Glu Ala Val Pro 1 5 <210> 398 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 398 Asp Gly Lys Ile Leu Val Ser Val Cys Asp Ser Asp Ser Ser Asn Ile 1 5 10 15 Asn Thr Thr Tyr 20 <210> 399 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 399 Phe Pro Leu Val Lys Asn Lys Val Ile Lys 1 5 10 <210> 400 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 400 Glu Ile Thr Met Ser Asp Asp 1 5 <210> 401 <211> 34 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 401 Glu Trp Gln Lys Leu Met His Phe Phe Pro Asp Leu Phe Asn Arg Pro 1 5 10 15 Ala Ile Thr Leu Val Ile Lys Ile Thr Arg Ile Asn Gln Thr Val Ile 20 25 30 His Ser <210> 402 <211> 37 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 402 Leu Arg Leu Ser Glu Thr Lys Tyr Ala Ile Ala Val Lys Arg Thr Ile 1 5 10 15 Thr Asn Arg Asn Arg Met Gln Pro Ala Gln Glu His Cys Gln Arg Ile 20 25 30 Asn Asn Ile Phe Thr 35 <210> 403 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 403 Ile Arg Ile Phe Phe 1 5 <210> 404 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 404 Tyr Leu Glu Cys Cys Phe Pro Gly Asp Arg Ser Gly Glu 1 5 10 <210> 405 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 405 Pro Cys Ile Ile Arg Ser Thr Asp Lys Met Leu Asp Gly Arg Lys Arg 1 5 10 15 His Lys Phe Arg Gln Pro Val 20 <210> 406 <211> 35 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 406 Ser Asp His Leu Ile Cys Asn Ile Ile Gly Asn Ala Thr Phe Ala Met 1 5 10 15 Phe Gln Lys Gln Leu Trp Arg Ile Gly Leu Pro Ile Gln Ser Ile Asp 20 25 30 Cys Arg Thr 35 <210> 407 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 407 Leu Pro Asp Ile Ile Ala Ser Pro Phe Ile Pro Ile 1 5 10 <210> 408 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 408 Ile Ser Ile His Val Gly Ile 1 5 <210> 409 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 409 Ser Arg Pro Arg Ala Arg Arg Phe Pro Leu Asn Met Ala His 1 5 10 <210> 410 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> HIVgag short CD8 T cell epitope <400> 410 Ala Met Gln Met Leu Lys Glu Thr Ile 1 5

Claims (23)

  1. (a) SAdV-A1302의 헥손 단백질, SEQ ID NO: 9의 아미노산 1 내지 950; SAdV-A1320의 헥손 단백질, SEQ ID NO: 34의 아미노산 1 내지 943; SAdV-A1331의 헥손 단백질, SEQ ID NO: 59의 아미노산 1 내지 944; SAdV-A1337의 헥손 단백질, SEQ ID NO: 86의 아미노산 1 내지 931;
    (b) SAdV-A1302의 펜톤 단백질, SEQ ID NO: 5의 아미노산 1 내지 528; SAdV-A1320의 펜톤 단백질, SEQ ID NO: 29의 아미노산 1 내지 542; SAdV-A1331의 펜톤 단백질, SEQ ID NO: 54의 아미노산 1 내지 539; SAdV-A1337의 펜톤 단백질, SEQ ID NO: 81의 아미노산 1 내지 532; 및
    (c) SAdV-A1302의 섬유 단백질, SEQ ID NO: 19의 아미노산 1 내지 440; SAdV-A1320의 섬유 단백질, SEQ ID NO: 44의 아미노산 1 내지 445; SAdV-A1331의 섬유 단백질, SEQ ID NO: 69의 아미노산 1 내지 445; SAdV-A1337의 섬유 단백질, SEQ ID NO: 96의 아미노산 1 내지 490
    로 구성된 군으로부터 선택된 캡시드 단백질을 포함하는 캡시드를 갖는 아데노바이러스로서,
    상기 캡시드는 발현 제어 서열에 작동 가능하게 결합된 유전자를 가지고 있는 이종 기원 분자를 캡시드화하며, 발현 제어 서열은 숙주 세포에서 유전자의 전사, 번역, 및/또는 발현을 지시하는 아데노바이러스.
  2. 제1 항에 있어서, 복제 및 캡시드화에 필요한 5' 및 3' 아데노바이러스 씨스-요소를 더 포함하는 것을 특징으로 하는 아데노바이러스.
  3. 제1 항에 있어서, 상기 아데노바이러스는 E1 유전자 모두 또는 일부가 결핍된 것을 특징으로 하는 아데노바이러스.
  4. 제3 항에 있어서, 상기 아데노바이러스가 복제-결함인 것을 특징으로 하는 아데노바이러스.
  5. 제1 항에 있어서, 상기 바이러스는 하이브리드 캡시드인 것을 특징으로 하는 아데노바이러스.
  6. 제5 항에 있어서, 상기 벡터는 SAdV-A1302, SAdV-A1320, SAdV-A1331, 및 SAdV-1337로부터 선택된 하나 이상의 캡시드 단백질을 포함하는 것을 특징으로 하는 아데노바이러스.
  7. 원숭이 아데노바이러스 헥손 단백질의 단편 및 SAdV에 이종 기원인 핵산 서열을 함유하는 헥손을 포함하는 캡시드를 갖는 재조합 아데노바이러스로서, SAdV 헥손 단백질의 단편은 길이가 약 50개의 아미노산의 N-말단 또는 C-말단 절단을 갖는 SEQ ID NO: 9, 34, 59, 또는 86의 SAdV 헥손 단백질이거나,
    SEQ ID NO: 9, 34, 59, 또는 86의 아미노산 잔기 125 내지 443; SEQ ID NO: 9, 34, 59, 또는 86의 아미노산 잔기 138 내지 441; SEQ ID NO: 9, 34, 59, 또는 86의 아미노산 잔기 138 내지 163; SEQ ID NO: 9, 34, 59, 또는 86의 아미노산 잔기 170 내지 176; 및 내지 SEQ ID NO: 9, 34, 59, 또는 86의 아미노산 잔기 404 내지 430으로 구성된 군으로부터 선택되는 재조합 아데노바이러스.
  8. 제7 항에 있어서, 캡시드는 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 섬유 단백질을 더 포함하는 것을 특징으로 하는 재조합 아데노바이러스.
  9. 제7 항에 있어서, 캡시드는 SAdV-A1302, AAdV-A1320, SAdV-A1331, 또는 SAdV-1337 펜톤 단백질을 더 포함하는 것을 특징으로 하는 재조합 아데노바이러스.
  10. 제7 항에 있어서, 상기 아데노바이러스는 복제 및 캡시드화에 필요한 5' 및 3' 아데노바이러스 씨스-요소를 포함하는 위형 아데노바이러스이고, 상기 씨스-요소는 아데노바이러스 5' 역위 말단 반복 부위 및 아데노바이러스 3' 역위 말단 반복 부위를 포함하는 것을 특징으로 하는 재조합 아데노바이러스.
  11. 제7 항에 있어서, 아데노바이러스가 숙주 세포에서 상기 생성물의 발현을 지시하는 서열에 작동 가능하게 결합된 생성물을 암호화하는 핵산 서열을 포함하는 것을 특징으로 하는 재조합 아데노바이러스.
  12. 제7 항에 있어서, 재조합 아데노바이러스가 하나 이상의 아데노바이러스 유전자를 포함하는 것을 특징으로 하는 재조합 아데노바이러스.
  13. 제7 항에 있어서, 재조합 아데노바이러스가 복제-결함인 것을 특징으로 하는 재조합 아데노바이러스.
  14. 제13 항에 있어서, 재조합 아데노바이러스가 아데노바이러스 E1에서 결실되는 것을 특징으로 하는 재조합 아데노바이러스.
  15. 약학적으로 허용 가능한 담체에서 제1 항 내지 제14 항 중 어느 한 항에 따르는 바이러스를 포함하는 조성물.
  16. 제1 항 내지 제14 항 중 어느 한 항에 따르는 바이러스를 대상에게 전달하는 단계를 포함하는 아데노바이러스 수용체를 갖는 세포를 표적화하는 방법.
  17. SEQ ID NO:1의 원숭이 아데노바이러스 A1302 핵산 1 내지 36430 및 그것의 보체;
    SEQ ID NO:25의 원숭이 아데노바이러스 A1320 핵산 1 내지 36603 및 그것의 보체;
    SEQ ID NO:50의 원숭이 아데노바이러스 A1331 핵산 1 내지 36647 및 그것의 보체; 및
    SEQ ID NO:77의 원숭이 아데노바이러스 A1337 핵산 1 내지 36639 및 그것의 보체
    로 구성된 군으로부터 선택된 분리된 원숭이 아데노바이러스 핵산.
  18. (a) SAdV-A1331 (SEQ ID NO: 50) 및 SAdV-A1337 (SEQ ID NO: 77)의 5 ' 역위 말단 반복 부위 (ITR) 서열;
    (b) SAdV-A1331 (SEQ ID NO: 50) 및 SAdV-A1337 (SEQ ID NO: 77)의 아데노바이러스 E1a 영역;
    (c) SAdV-A1302 (SEQ ID NO: 1), SAdV-A1320 (SEQ ID NO: 25), SAdV-A1331 (SEQ ID NO: 50), 및 SAdV-A1337 (SEQ ID NO: 77)의 작은 T 및 큰 T 영역에 대한 오픈 리딩 프레임으로 구성된 군으로부터 선택된 아데노바이러스 E1b 영역, 또는 이것의 단편;
    (d) SAdV-A1302 (SEQ ID NO: 1), SAdV-A1320 (SEQ ID NO: 25), SAdV-A1331 (SEQ ID NO: 50), 및 SAdV-A1337 (SEQ ID NO: 77)의 pTP, 폴리머라제, 및 IVa 영역에 대한 오픈 리딩 프레임을 포함하는 E2b 영역;
    (e) SAdV-A1302 (SEQ ID NO: 1), SAdV-A1320 (SEQ ID NO: 25), SAdV-A1331 (SEQ ID NO: 50), 및 SAdV-A1337 (SEQ ID NO: 77)의 52/55 kD 및 IIIa 영역에 대한 오픈 리딩 프레임으로 구성된 군으로부터 선택된 LI 영역, 또는 이것의 단편;
    (f) SAdV-A1302 (SEQ ID NO: 1), SAdV-A1320 (SEQ ID NO: 25), SAdV-A1331 (SEQ ID NO: 50), 및 SAdV-A1337 (SEQ ID NO: 77)의 펜톤, VII, V, 및 X 영역에 대한 오픈 리딩 프레임으로 구성된 군으로부터 선택된 L2 영역, 또는 이것의 단편;
    (g) SAdV-A1302 (SEQ ID NO: 1), SAdV-A1320 (SEQ ID NO: 25), SAdV-A1331 (SEQ ID NO: 50), 및 SAdV-Al 337 (SEQ ID NO: 77)의 VI, 헥손, 및 엔도프로테아제 영역에 대한 오픈 리딩 프레임으로 구성된 군으로부터 선택된 L3 영역, 또는 이것의 단편;
    (h) SAdV-A1302 (SEQ ID NO: 1), SAdV-A1320 (SEQ ID NO: 25), SAdV-A1331 (SEQ ID NO: 50), 및 SAdV-A1337 (SEQ ID NO: 77)의 DNA-결합 단백질 (DBP) 영역에 대한 오픈 리딩 프레임을 포함하는 E2a 단백질;
    (i) SAdV-A1302 (SEQ ID NO: 1), SAdV-A1320 (SEQ ID NO: 25), SAdV-A1331 (SEQ ID NO: 50), 및 SAdV-A1337 (SEQ ID NO: 77)의 100 kD, 22kD, 및 VIII 영역에 대한 오픈 리딩 프레임으로 구성된 군으로부터 선택된 L4 영역, 또는 이것의 단편;
    (j) SAdV-A1302 (SEQ ID NO: 1), SAdV-A1320 (SEQ ID NO: 25), SAdV-A1331 (SEQ ID NO: 50), 및 SAdV-A1337 (SEQ ID NO: 77)의 12.5K, CR1-알파, gp19K, CR1-베타, CR1-감마, CR1-델타, RID-베타, 및 14.7K 영역에 대한 오픈 리딩 프레임으로 구성된 군으로부터 선택된 E3 영역, 또는 이것의 단편;
    (k) SAdV-A1302 (SEQ ID NO: 1), SAdV-A1320 (SEQ ID NO: 25), SAdV-A1331 (SEQ ID NO: 50), 및 SAdV-A1337 (SEQ ID NO: 77)의 섬유 단백질에 대한 오픈 리딩 프레임으로 구성된 군으로부터 선택된 L5 영역, 또는 이것의 단편;
    (l) SAdV-A1331 (SEQ ID NO: 50) 및 SAdV-A1337 (SEQ ID NO: 77)의 E4 ORF6/7, E4 ORF6, E4 ORF4, E4 ORF3, E4 ORF2, 및 E4 ORF1 영역에 대한 오픈 리딩 프레임으로 구성된 군으로부터 선택된 E4 영역, 또는 이것의 단편;
    (m) SAdV-A1302 (SEQ ID NO: 1)의 E4 ORF6/7, E4 ORF6, E4 ORF4, E4 ORF3, 및 E4 ORF2 영역에 대한 오픈 리딩 프레임으로 구성된 군으로부터 선택된 E4 영역, 또는 이것의 단편;
    (n) SAdV-A1320 (SEQ ID NO: 25)의 E4 ORF6/7, E4 ORF6, 및 E4 ORF4 영역에 대한 오픈 리딩 프레임으로 구성된 군으로부터 선택된 E4 영역, 또는 이것의 단편; 및
    (o) SAdV-A1331 (SEQ ID NO: 50) 및 SAdV-A1337 (SEQ ID NO: 77)의 3' ITR
    로 구성된 군으로부터 선택된 하나 이상의 원숭이 아데노바이러스 핵산 서열을 포함하는 벡터.
  19. 제18 항에 따르는 핵산 서열에 의해 암호화된 원숭이 아데노바이러스 단백질.
  20. E1a, SEQ ID NO: 76, 103;
    E1b, 작은 T/19K, SEQ ID NO: 2, 26, 51, 78;
    E1b, 큰 T/55K, SEQ ID NO: 21, 46, 71, 98;
    52/55D, SEQ ID NO: 3,27,52,79;
    IIIa, SEQ ID NO: 4, 28, 53, 80;
    펜톤, SEQ ID NO: 5, 29, 54, 81;
    VII, SEQ ID NO: 30, 55, 82;
    V, SEQ ID NO: 6, 31, 56, 83;
    pX, SEQ ID NO: 7, 32, 57, 84;
    VI, SEQ ID NO: 8, 33, 58, 85;
    헥손, SEQ ID NO: 9, 34, 59, 86;
    엔도프로테아제, SEQ ID NO: 10, 35, 60, 87;
    100 kD, SEQ ID NO: 11, 36, 61, 88;
    22 kD, SEQ ID NO: 22, 47, 72, 99;
    VIII, SEQ ID NO: 12, 37, 62, 89;
    E3/12.5 K, SEQ ID NO: 13, 38, 63, 90;
    CR1-알파 SEQ ID NO: 23, 48, 73, 100;
    gp19K, SEQ ID NO: 14, 39, 64, 91;
    CR1-베타, SEQ ID NO: 15, 40, 65, 92;
    CR1-감마, SEQ ID NO: 16, 41, 66, 93;
    CR1-델타, SEQ ID NO: 17, 42, 69, 94;
    RID-베타, SEQ ID NO: 18, 43, 68, 95;
    E3/14.7K, SEQ ID NO: 24, 49, 74, 101; 및
    섬유, SEQ ID NO: 19, 44, 69, 96
    으로 구성된 군으로부터 선택된 하나 이상의 원숭이 아데노바이러스 단백질을 포함하는 조성물.
  21. 제20 항에 따르는 조성물을 대상에 전달하는 단계를 포함하는 아데노바이러스 수용체를 갖는 세포를 표적화하는 방법으로서, 상기 조성물은 헥손, 펜톤 및 섬유로부터 선택된 하나 이상의 원숭이 아데노바이러스 SAdV-A1302, SAdV-A1320, SAdV-A1331, 또는 SAdV-A1337 단백질을 포함하는 방법.
  22. 분자를 표적 세포에 전달하는데 사용되는 제1 항 내지 제6 항 중 어느 한 항에 따르는 아데노바이러스 또는 제7 항 내지 제14 항 중 어느 한 항에 따르는 재조합 아데노바이러스.
  23. 분자를 표적 세포에 전달하는데 유용한 의약품의 제조에 있어서 제1 항 내지 제6 항 중 어느 한 항에 따르는 아데노바이러스 또는 제7 항 내지 제14 항 중 어느 한 항에 따르는 재조합 아데노바이러스의 사용.
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