UY36732A - Piridin pirazinonas novedosas como inhibidores de bromodominios de la familia bet - Google Patents

Piridin pirazinonas novedosas como inhibidores de bromodominios de la familia bet

Info

Publication number
UY36732A
UY36732A UY0001036732A UY36732A UY36732A UY 36732 A UY36732 A UY 36732A UY 0001036732 A UY0001036732 A UY 0001036732A UY 36732 A UY36732 A UY 36732A UY 36732 A UY36732 A UY 36732A
Authority
UY
Uruguay
Prior art keywords
pirazinonas
novedosas
bromodominium
piridin
inhibitors
Prior art date
Application number
UY0001036732A
Other languages
English (en)
Inventor
Casimiro-Garcia Agustin
Coe Jotham Wadsworth
Papaioannou Nikolaos
Lefker Bruce Allen
Narayanan Arjun Venkat
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of UY36732A publication Critical patent/UY36732A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen piridin pirazinonas novedosas o sales de estas aceptables desde el punto de vista farmacéutico. También se describen composiciones farmacéuticas y el uso de los compuestos para tratar enfermedades o trastornos que son dependientes del bromodominio de la familia BET. Además, se describen métodos para preparar y usar estos compuestos.
UY0001036732A 2015-06-18 2016-06-16 Piridin pirazinonas novedosas como inhibidores de bromodominios de la familia bet UY36732A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562181281P 2015-06-18 2015-06-18

Publications (1)

Publication Number Publication Date
UY36732A true UY36732A (es) 2017-01-31

Family

ID=56116484

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001036732A UY36732A (es) 2015-06-18 2016-06-16 Piridin pirazinonas novedosas como inhibidores de bromodominios de la familia bet

Country Status (6)

Country Link
US (1) US20160368919A1 (es)
AR (1) AR105042A1 (es)
CA (1) CA2933026A1 (es)
TW (1) TW201712011A (es)
UY (1) UY36732A (es)
WO (1) WO2016203335A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20181088A1 (es) * 2015-08-10 2018-07-09 Dana Farber Cancer Inst Inc Mecanismo de resistencia a inhibidores de bromodominio bet
TWI841598B (zh) * 2018-09-13 2024-05-11 大陸商恒翼生物醫藥（上海）股份有限公司 用於治療雌激素受體陽性乳癌之組合療法
US20220280590A1 (en) * 2019-08-20 2022-09-08 Georgetown University Use of inhibitors of yap and sox2 for the treatment of cancer
US12527741B2 (en) 2021-06-17 2026-01-20 Wisconsin Alumni Research Foundation Modular dendron micelles for treatment of pulmonary diseases related to fibrosis and viral infection including COVID-19
AU2023229284A1 (en) * 2022-03-04 2024-09-26 Yale University Methods and compositions for treating and preventing fibrosis

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Also Published As

Publication number Publication date
US20160368919A1 (en) 2016-12-22
TW201712011A (zh) 2017-04-01
WO2016203335A1 (en) 2016-12-22
AR105042A1 (es) 2017-08-30
CA2933026A1 (en) 2016-12-18

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Legal Events

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Effective date: 20221121