SV2016005305A - Compuestos heteroaromáticos y su uso como ligandos de dopamina d1 - Google Patents

Compuestos heteroaromáticos y su uso como ligandos de dopamina d1

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Publication number
SV2016005305A
SV2016005305A SV2016005305A SV2016005305A SV2016005305A SV 2016005305 A SV2016005305 A SV 2016005305A SV 2016005305 A SV2016005305 A SV 2016005305A SV 2016005305 A SV2016005305 A SV 2016005305A SV 2016005305 A SV2016005305 A SV 2016005305A
Authority
SV
El Salvador
Prior art keywords
diginates
dopamine
compounds
heteroaromatic compounds
schizophrenia
Prior art date
Application number
SV2016005305A
Other languages
English (en)
Inventor
Gray David Lawrence Firman
Lei Zhang
Michael Aaron Brodney
Michael Eric Green
Chakrapani Subramanyam
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53276921&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SV2016005305(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of SV2016005305A publication Critical patent/SV2016005305A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C—CHEMISTRY; METALLURGY
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

LA PRESENTE INVENCIÓN PROPORCIONA, EN PARTE, COMPUESTOS DE LA FÓRMULA I: (VER FORMULA); Y LAS SALES DE ESTOS ACEPTABLES DESDE EL PUNTO DE VISTA FARMACÉUTICO; PROCESOS PARA LA PREPARACIÓN DE; INTERMEDIARIOS USADOS EN LA PREPARACIÓN DE; Y COMPOSICIONES QUE CONTIENEN ESTOS COMPUESTOS O SALES, Y SUS USOS PARA TRATAR TRASTORNOS MEDIADOS POR D1 (O ASOCIADOS A D1) QUE INCLUYEN, POR EJEMPLO, ESQUIZOFRENIA (POR EJEMPLO, SUS SÍNTOMAS COGNITIVOS Y NEGATIVOS), TRASTORNO ESQUIZOTÍPICO DE LA PERSONALIDAD, DEFICIENCIA COGNITIVA (POR EJEMPLO, DEFICIENCIA COGNITIVA ASOCIADA A ESQUIZOFRENIA, AD, PD O TRATAMIENTO DE FARMACOTERAPIA), ADHD, ENFERMEDAD DE PARKINSON, ANSIEDAD Y DEPRESIÓN
SV2016005305A 2014-04-25 2016-10-25 Compuestos heteroaromáticos y su uso como ligandos de dopamina d1 SV2016005305A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461984079P 2014-04-25 2014-04-25

Publications (1)

Publication Number Publication Date
SV2016005305A true SV2016005305A (es) 2017-07-19

Family

ID=53276921

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2016005305A SV2016005305A (es) 2014-04-25 2016-10-25 Compuestos heteroaromáticos y su uso como ligandos de dopamina d1

Country Status (26)

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US (2) US9540352B2 (es)
EP (1) EP3134404A1 (es)
JP (1) JP6239149B2 (es)
KR (1) KR20160142402A (es)
CN (1) CN107074843A (es)
AP (1) AP2016009512A0 (es)
AU (1) AU2015249497A1 (es)
BR (1) BR112016023740A2 (es)
CA (1) CA2946475A1 (es)
CL (1) CL2016002677A1 (es)
CR (1) CR20160494A (es)
CU (1) CU20160156A7 (es)
DO (1) DOP2016000289A (es)
EA (1) EA201691788A1 (es)
IL (1) IL248132A0 (es)
MA (1) MA39914A (es)
MD (1) MD20160109A2 (es)
MX (1) MX2016013969A (es)
NI (1) NI201600161A (es)
PE (1) PE20170009A1 (es)
PH (1) PH12016501993A1 (es)
SG (1) SG11201608468TA (es)
SV (1) SV2016005305A (es)
TN (1) TN2016000447A1 (es)
TW (1) TWI561517B (es)
WO (1) WO2015162516A1 (es)

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EA201691831A1 (ru) * 2014-04-25 2017-02-28 Пфайзер Инк. Гетероароматические соединения и их применение в качестве допаминовых d1 лигандов
EP3134405B1 (en) 2014-04-25 2019-08-28 Pfizer Inc Heteroaromatic compounds and their use as dopamine d1 ligands
JP6564394B2 (ja) 2014-04-28 2019-08-21 ファイザー・インク 複素環式化合物およびそのドーパミンｄ１リガンドとしての使用
WO2015166370A1 (en) 2014-04-28 2015-11-05 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands
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EP3134405B1 (en) 2014-04-25 2019-08-28 Pfizer Inc Heteroaromatic compounds and their use as dopamine d1 ligands
WO2015166370A1 (en) 2014-04-28 2015-11-05 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands
JP6564394B2 (ja) 2014-04-28 2019-08-21 ファイザー・インク 複素環式化合物およびそのドーパミンｄ１リガンドとしての使用

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US9850232B2 (en) 2017-12-26
TWI561517B (en) 2016-12-11
TW201604188A (zh) 2016-02-01
JP6239149B2 (ja) 2017-11-29
NI201600161A (es) 2016-11-25
MX2016013969A (es) 2017-01-11
EA201691788A1 (ru) 2017-03-31
TN2016000447A1 (en) 2018-04-04
CA2946475A1 (en) 2015-10-29
US20160200711A1 (en) 2016-07-14
AP2016009512A0 (en) 2016-10-31
SG11201608468TA (en) 2016-11-29
DOP2016000289A (es) 2017-02-15
PH12016501993A1 (en) 2017-01-09
CN107074843A (zh) 2017-08-18
MD20160109A2 (ro) 2017-04-30
BR112016023740A2 (pt) 2017-08-15
US9540352B2 (en) 2017-01-10
KR20160142402A (ko) 2016-12-12
EP3134404A1 (en) 2017-03-01
AU2015249497A1 (en) 2016-10-20
JP2017513881A (ja) 2017-06-01
IL248132A0 (en) 2016-11-30
PE20170009A1 (es) 2017-03-17
US20150307494A1 (en) 2015-10-29
CU20160156A7 (es) 2017-02-02
MA39914A (fr) 2017-03-01
CL2016002677A1 (es) 2017-02-10
CR20160494A (es) 2016-12-20
WO2015162516A1 (en) 2015-10-29

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