MD20160109A2 - Compuşi heteroaromatici şi utilizarea lor ca liganzi ai dopaminei D1 - Google Patents

Compuşi heteroaromatici şi utilizarea lor ca liganzi ai dopaminei D1 Download PDF

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Publication number
MD20160109A2
MD20160109A2 MDA20160109A MD20160109A MD20160109A2 MD 20160109 A2 MD20160109 A2 MD 20160109A2 MD A20160109 A MDA20160109 A MD A20160109A MD 20160109 A MD20160109 A MD 20160109A MD 20160109 A2 MD20160109 A2 MD 20160109A2
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MD
Moldova
Prior art keywords
disease
compounds
dopamine
ligands
schizophrenia
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Application number
MDA20160109A
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English (en)
Russian (ru)
Inventor
Дэвид Лоуренс Фирмэн ГРЕЙ
Лэй Чжан
Майкл Аарон Бродни
Майкл Эрик Грин
Чакрапани СУБРАМАНЬЯМ
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Pfizer Inc.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53276921&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD20160109(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of MD20160109A2 publication Critical patent/MD20160109A2/ro

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

Prezenta invenţie dezvăluie, în parte, compuşii cu Formula I:Işi sărurile farmaceutic acceptabile ale acestora; procese de preparare; intermediari utilizaţi în preparare; compoziţii ce conţin asemenea compuşi sau săruri, precum şi utilizarea lor pentru tratarea tulburărilor D1-mediate (sau D1-asociate) inclusiv, de ex., schizofrenia (de ex., simptomele cognitive şi negative ale acesteia), tulburare de personalitate schizotipală, deteriorare cognitivă (de ex., deteriorare cognitivă asociată cu schizofrenia, boala Alzheimer, boala Parkinson sau terapia farmacologică), ADHD (tulburare hiperchinetică cu deficit de atenţie), boala Parkinson, anxietate şi depresie.
MDA20160109A 2014-04-25 2015-04-09 Compuşi heteroaromatici şi utilizarea lor ca liganzi ai dopaminei D1 MD20160109A2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461984079P 2014-04-25 2014-04-25
PCT/IB2015/052604 WO2015162516A1 (en) 2014-04-25 2015-04-09 Heteroaromatic compounds and their use as dopamine d1 ligands

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MD20160109A2 true MD20160109A2 (ro) 2017-04-30

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ID=53276921

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MDA20160109A MD20160109A2 (ro) 2014-04-25 2015-04-09 Compuşi heteroaromatici şi utilizarea lor ca liganzi ai dopaminei D1

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US (2) US9540352B2 (ro)
EP (1) EP3134404A1 (ro)
JP (1) JP6239149B2 (ro)
KR (1) KR20160142402A (ro)
CN (1) CN107074843A (ro)
AP (1) AP2016009512A0 (ro)
AU (1) AU2015249497A1 (ro)
BR (1) BR112016023740A2 (ro)
CA (1) CA2946475A1 (ro)
CL (1) CL2016002677A1 (ro)
CR (1) CR20160494A (ro)
CU (1) CU20160156A7 (ro)
DO (1) DOP2016000289A (ro)
EA (1) EA201691788A1 (ro)
IL (1) IL248132A0 (ro)
MA (1) MA39914A (ro)
MD (1) MD20160109A2 (ro)
MX (1) MX2016013969A (ro)
NI (1) NI201600161A (ro)
PE (1) PE20170009A1 (ro)
PH (1) PH12016501993A1 (ro)
SG (1) SG11201608468TA (ro)
SV (1) SV2016005305A (ro)
TN (1) TN2016000447A1 (ro)
TW (1) TWI561517B (ro)
WO (1) WO2015162516A1 (ro)

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JP2017513881A (ja) 2017-06-01
PH12016501993A1 (en) 2017-01-09
US9540352B2 (en) 2017-01-10
DOP2016000289A (es) 2017-02-15
NI201600161A (es) 2016-11-25
US20150307494A1 (en) 2015-10-29
SG11201608468TA (en) 2016-11-29
PE20170009A1 (es) 2017-03-17
CL2016002677A1 (es) 2017-02-10
CR20160494A (es) 2016-12-20
US9850232B2 (en) 2017-12-26
EA201691788A1 (ru) 2017-03-31
KR20160142402A (ko) 2016-12-12
TWI561517B (en) 2016-12-11
CN107074843A (zh) 2017-08-18
CU20160156A7 (es) 2017-02-02
TW201604188A (zh) 2016-02-01
MA39914A (fr) 2017-03-01
BR112016023740A2 (pt) 2017-08-15
AP2016009512A0 (en) 2016-10-31
AU2015249497A1 (en) 2016-10-20
MX2016013969A (es) 2017-01-11
US20160200711A1 (en) 2016-07-14
IL248132A0 (en) 2016-11-30
WO2015162516A1 (en) 2015-10-29
CA2946475A1 (en) 2015-10-29
EP3134404A1 (en) 2017-03-01
SV2016005305A (es) 2017-07-19
JP6239149B2 (ja) 2017-11-29
TN2016000447A1 (en) 2018-04-04

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