CL2013002424A1 - Compuestos derivados de (piridin-4-il)-bencilamidas como moduladores alostericos de nachr alfa-7; composicion farmaceutica; proceso para preparar la composicion farmaceutica; y uso en el tratamiento de enfermedades como alzheimer, ansiedad, esquizofrenia, parkinson, entre otras. - Google Patents
Compuestos derivados de (piridin-4-il)-bencilamidas como moduladores alostericos de nachr alfa-7; composicion farmaceutica; proceso para preparar la composicion farmaceutica; y uso en el tratamiento de enfermedades como alzheimer, ansiedad, esquizofrenia, parkinson, entre otras.Info
- Publication number
- CL2013002424A1 CL2013002424A1 CL2013002424A CL2013002424A CL2013002424A1 CL 2013002424 A1 CL2013002424 A1 CL 2013002424A1 CL 2013002424 A CL2013002424 A CL 2013002424A CL 2013002424 A CL2013002424 A CL 2013002424A CL 2013002424 A1 CL2013002424 A1 CL 2013002424A1
- Authority
- CL
- Chile
- Prior art keywords
- pharmaceutical composition
- benzylamides
- nachr
- alfa
- schizophrenia
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11155937 | 2011-02-25 |
Publications (1)
Publication Number | Publication Date |
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CL2013002424A1 true CL2013002424A1 (es) | 2014-03-28 |
Family
ID=44259750
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2013002424A CL2013002424A1 (es) | 2011-02-25 | 2013-08-22 | Compuestos derivados de (piridin-4-il)-bencilamidas como moduladores alostericos de nachr alfa-7; composicion farmaceutica; proceso para preparar la composicion farmaceutica; y uso en el tratamiento de enfermedades como alzheimer, ansiedad, esquizofrenia, parkinson, entre otras. |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP2678315B1 (es) |
JP (1) | JP5841617B2 (es) |
KR (1) | KR101851140B1 (es) |
CN (1) | CN103402983B (es) |
AU (1) | AU2012219537B2 (es) |
BR (1) | BR112013021599A2 (es) |
CA (1) | CA2824350C (es) |
CL (1) | CL2013002424A1 (es) |
EA (1) | EA022164B1 (es) |
ES (1) | ES2563113T3 (es) |
HK (1) | HK1189222A1 (es) |
IL (1) | IL228054A (es) |
MX (1) | MX345656B (es) |
MY (1) | MY161236A (es) |
SG (1) | SG192939A1 (es) |
UA (1) | UA109803C2 (es) |
WO (1) | WO2012113850A2 (es) |
ZA (1) | ZA201306385B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
JP2011500625A (ja) | 2007-10-18 | 2011-01-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | トリ置換された1,2,4−トリアゾール |
AR070936A1 (es) | 2008-03-19 | 2010-05-12 | Janssen Pharmaceutica Nv | 1,2,4 -triazoles trisustituidos |
KR20110007234A (ko) | 2008-05-09 | 2011-01-21 | 얀센 파마슈티카 엔.브이. | 아세틸콜린 수용체 조절제로서의 삼치환된 피라졸 |
CN107922426B (zh) | 2015-08-19 | 2021-03-26 | 安斯泰来制药株式会社 | 四氢噁庚英吡啶化合物 |
JP7055378B2 (ja) | 2015-09-17 | 2022-04-18 | ユニバーシティ・オブ・ノートル・ダム・デュ・ラック | マイコバクテリア感染症に対して有用なベンジルアミン含有複素環化合物及び組成物 |
CN108689957B (zh) * | 2018-07-23 | 2020-07-03 | 南京药石科技股份有限公司 | 一种2r/2s-三氟甲基吗啉及其盐酸盐的制备方法和应用 |
WO2020064655A1 (en) * | 2018-09-24 | 2020-04-02 | Astrazeneca Ab | Azd0328 dosage regime for treating cognitive impairment |
CN113264867A (zh) * | 2021-06-08 | 2021-08-17 | 安徽星宇化工有限公司 | 一种顺式2,6-二甲基哌啶的制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1913901A (zh) * | 2004-02-04 | 2007-02-14 | 神经研究公司 | 作为胆碱能受体调节剂的二氮杂双环芳基衍生物 |
JPWO2006082952A1 (ja) * | 2005-02-01 | 2008-06-26 | 武田薬品工業株式会社 | アミド化合物 |
US20080261999A1 (en) * | 2005-03-04 | 2008-10-23 | Fionna Mitchell Martin | Azabicycloalkane Derivatives Useful as Nicotinic Acetylcholine Receptor Agonists |
CN101263130B (zh) | 2005-09-13 | 2011-03-09 | 詹森药业有限公司 | 2-苯胺-4-芳基取代的噻唑衍生物 |
JO3019B1 (ar) | 2006-04-19 | 2016-09-05 | Janssen Pharmaceutica Nv | ثلاثي مستبدل 4،2،1-ثلاثي زولات |
RS52062B (en) * | 2006-05-19 | 2012-06-30 | Abbott Laboratories | CNS ACTIVE AZABICYCLIC ALKANINE DERIVATIVES SUBSTITUTED BY MIXED BICYCLOHETEROCYCLES |
CN101595084B (zh) * | 2006-06-29 | 2013-01-02 | 金克斯医药品有限公司 | 用于调整激酶级联的二芳基组合物和方法 |
CN101553486A (zh) * | 2006-10-25 | 2009-10-07 | 神经研究公司 | 二唑和噻二唑化合物以及它们作为烟碱乙酰胆碱受体调节剂的用途 |
JP2011500625A (ja) | 2007-10-18 | 2011-01-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | トリ置換された1,2,4−トリアゾール |
JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
AR070936A1 (es) | 2008-03-19 | 2010-05-12 | Janssen Pharmaceutica Nv | 1,2,4 -triazoles trisustituidos |
CN102066337A (zh) * | 2008-04-22 | 2011-05-18 | 第一三共株式会社 | 5-羟基嘧啶-4-甲酰胺化合物 |
KR20110007234A (ko) * | 2008-05-09 | 2011-01-21 | 얀센 파마슈티카 엔.브이. | 아세틸콜린 수용체 조절제로서의 삼치환된 피라졸 |
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2012
- 2012-02-23 EA EA201391228A patent/EA022164B1/ru not_active IP Right Cessation
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2013
- 2013-08-21 IL IL228054A patent/IL228054A/en active IP Right Grant
- 2013-08-22 CL CL2013002424A patent/CL2013002424A1/es unknown
- 2013-08-23 ZA ZA2013/06385A patent/ZA201306385B/en unknown
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2014
- 2014-03-04 HK HK14102158.8A patent/HK1189222A1/zh not_active IP Right Cessation
Also Published As
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ZA201306385B (en) | 2015-03-25 |
EP2678315A2 (en) | 2014-01-01 |
CA2824350C (en) | 2019-07-02 |
KR101851140B1 (ko) | 2018-04-23 |
WO2012113850A3 (en) | 2012-10-18 |
MY161236A (en) | 2017-04-14 |
CN103402983B (zh) | 2015-12-23 |
AU2012219537A1 (en) | 2013-07-18 |
ES2563113T3 (es) | 2016-03-10 |
BR112013021599A2 (pt) | 2016-11-16 |
CN103402983A (zh) | 2013-11-20 |
MX345656B (es) | 2017-02-08 |
IL228054A (en) | 2016-06-30 |
UA109803C2 (xx) | 2015-10-12 |
KR20140014163A (ko) | 2014-02-05 |
CA2824350A1 (en) | 2012-08-30 |
MX2013009798A (es) | 2013-09-26 |
HK1189222A1 (zh) | 2014-05-30 |
JP5841617B2 (ja) | 2016-01-13 |
JP2014506587A (ja) | 2014-03-17 |
NZ612688A (en) | 2015-08-28 |
EA022164B1 (ru) | 2015-11-30 |
WO2012113850A2 (en) | 2012-08-30 |
EP2678315B1 (en) | 2015-12-16 |
AU2012219537B2 (en) | 2016-07-28 |
SG192939A1 (en) | 2013-09-30 |
EA201391228A1 (ru) | 2013-12-30 |
IL228054A0 (en) | 2013-09-30 |
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