AR070936A1 - 1,2,4 -triazoles trisustituidos - Google Patents

1,2,4 -triazoles trisustituidos

Info

Publication number
AR070936A1
AR070936A1 ARP090100970A ARP090100970A AR070936A1 AR 070936 A1 AR070936 A1 AR 070936A1 AR P090100970 A ARP090100970 A AR P090100970A AR P090100970 A ARP090100970 A AR P090100970A AR 070936 A1 AR070936 A1 AR 070936A1
Authority
AR
Argentina
Prior art keywords
alkyl
cycloalkyl
hydrogen
alkyloxy
halo
Prior art date
Application number
ARP090100970A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR070936A1 publication Critical patent/AR070936A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se refiere a procesos para su preparacion; composiciones farmacéuticas que contienen dichos compuestos; y su uso en tratamientos, de acuerdo con la formula (1). Se refiere, en particular, a potentes moduladores alostéricos positivos de receptores de acetilcolina nicotínicos, donde dichos moduladores alostéricos positivos tienen la capacidad de incrementar la eficacia de agonistas de receptores nicotínicos. Reivindicacion 1: Un compuesto de acuerdo con la formula (1) o una de sus formas estereoisomeras, donde: R1 es fenilo no sustituido; benzodioxan-6-ilo no sustituido; piridinilo no sustituido; o fenilo o piridinilo sustituido con 1, 2 o 3 sustituyentes seleccionados del grupo que consiste en halo, trifluorometilo, trifluorometoxi, alquilo C1-3, alquiloxi C1-3, alquiloxi C1-3-alquilo C1-3, alquilamino C1-3, cicloalquilo C3-6, cicloalquiloxi C3-6, cicloalquilamino C3-6, cicloalquilo C3-6-alquilo C1-3, cicloalquilo C3-6-alquiloxi C1-3, y cicloalquilo C3-6-alquilamino C1-3; R2 es hidrogeno, halo, alquilo C1-3, alquiloxi C1-3 o trifluorometoxi; R3 es hidrogeno, halo, o trifluorometilo; R4 es hidrogeno, o halo; R2 y R3 pueden formar un radical -OCF2-O-; Alk es alcanodiilo C1-6 o alquenodiilo C2-6 recto o ramificado; R5 es hidrogeno, hidroxi, alquiloxi C1-3, halo, R6R7N-C(=O)- o R8-O-C(=O)-; R6 es alquilo C1-3, cicloalquilo C3-6 o cicloalquilo C3-6-alquilo C1-3; R7 es hidrogeno o alquilo C1-3; o R6 y R7 forman pirrolidinilo o piperidinilo, donde cada uno está opcionalmente sustituido con hidroxilo; R8 es hidrogeno o alquilo C1-4; o una sal de adicion aceptable para uso farmacéutico, o un hidrato o un solvato de dicho compuesto.
ARP090100970A 2008-03-19 2009-03-18 1,2,4 -triazoles trisustituidos AR070936A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08152987 2008-03-19

Publications (1)

Publication Number Publication Date
AR070936A1 true AR070936A1 (es) 2010-05-12

Family

ID=39670401

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090100970A AR070936A1 (es) 2008-03-19 2009-03-18 1,2,4 -triazoles trisustituidos

Country Status (21)

Country Link
US (1) US8778974B2 (es)
EP (1) EP2257535B1 (es)
JP (1) JP5383788B2 (es)
KR (1) KR101564303B1 (es)
CN (1) CN102066343B (es)
AR (1) AR070936A1 (es)
AU (1) AU2009226988B2 (es)
CA (1) CA2714662C (es)
CL (1) CL2009000662A1 (es)
EA (1) EA018186B1 (es)
ES (1) ES2442932T3 (es)
IL (1) IL208181A (es)
MX (1) MX2010010127A (es)
MY (1) MY152486A (es)
NZ (1) NZ587669A (es)
PE (1) PE20091618A1 (es)
TW (1) TWI433847B (es)
UA (1) UA102681C2 (es)
UY (1) UY31721A1 (es)
WO (1) WO2009115547A1 (es)
ZA (1) ZA201006690B (es)

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JO2784B1 (en) * 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
CL2009001125A1 (es) * 2008-05-09 2011-02-11 Janssen Pharmaceutica Nv Compuestos derivados de pirazol trisustituido, moduladores alostericos positivos de los receptores ach nicotinicos; composicion farmaceutica que los comprende; proceso de preparacion de la composicion; y su uso en el tratamiento de enfermedades de snc o inflamatorias.
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JP7343170B2 (ja) 2017-05-12 2023-09-12 ボード オブ トラスティーズ オブ ザ サザン イリノイ ユニバーシティ オン ビハーフ オブ サザン イリノイ ユニバーシティ エドワーズビル ３，４，５－三置換－１，２，４－トリアゾールおよび３，４，５－三置換－３－チオ－１，２，４－トリアゾール、ならびにそれらの使用
HU231333B1 (hu) 2018-07-13 2023-01-28 Richter Gedeon Nyrt Spirokromán származékok
HU231414B1 (hu) 2018-07-13 2023-08-28 Richter Gedeon Nyrt. Tiadiazin származékok
HU231478B1 (hu) 2018-07-13 2024-02-28 Richter Gedeon Nyrt. Szubsztituált (aza)indol származékok

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Also Published As

Publication number Publication date
AU2009226988A1 (en) 2009-09-24
ZA201006690B (en) 2012-03-28
JP2011515367A (ja) 2011-05-19
CA2714662A1 (en) 2009-09-24
CN102066343B (zh) 2013-12-04
ES2442932T3 (es) 2014-02-14
PE20091618A1 (es) 2009-10-23
CN102066343A (zh) 2011-05-18
WO2009115547A8 (en) 2009-11-26
CL2009000662A1 (es) 2010-02-05
EA018186B1 (ru) 2013-06-28
UA102681C2 (ru) 2013-08-12
AU2009226988B2 (en) 2013-05-23
EP2257535A1 (en) 2010-12-08
CA2714662C (en) 2016-05-10
IL208181A0 (en) 2010-12-30
IL208181A (en) 2013-10-31
NZ587669A (en) 2011-07-29
KR20100124258A (ko) 2010-11-26
MX2010010127A (es) 2010-10-25
US8778974B2 (en) 2014-07-15
WO2009115547A1 (en) 2009-09-24
EA201071094A1 (ru) 2011-02-28
TWI433847B (zh) 2014-04-11
TW201000471A (en) 2010-01-01
JP5383788B2 (ja) 2014-01-08
US20100324053A1 (en) 2010-12-23
MY152486A (en) 2014-10-15
UY31721A1 (es) 2009-09-30
KR101564303B1 (ko) 2015-11-06
EP2257535B1 (en) 2013-11-06

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