BR112012003592B8 - composição farmacêutica contendo derivado de quinolina - Google Patents

composição farmacêutica contendo derivado de quinolina

Info

Publication number
BR112012003592B8
BR112012003592B8 BR112012003592A BR112012003592A BR112012003592B8 BR 112012003592 B8 BR112012003592 B8 BR 112012003592B8 BR 112012003592 A BR112012003592 A BR 112012003592A BR 112012003592 A BR112012003592 A BR 112012003592A BR 112012003592 B8 BR112012003592 B8 BR 112012003592B8
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
composition containing
quinoline derivative
containing quinoline
hydrogen atom
Prior art date
Application number
BR112012003592A
Other languages
English (en)
Other versions
BR112012003592A2 (pt
BR112012003592B1 (pt
Inventor
Bando Masashi
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43607048&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012003592(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of BR112012003592A2 publication Critical patent/BR112012003592A2/pt
Publication of BR112012003592B1 publication Critical patent/BR112012003592B1/pt
Publication of BR112012003592B8 publication Critical patent/BR112012003592B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

composição farmacêutica contendo derivado de quinolina. a presente invenção refere-se a uma composição farmacêutica contendo um composto representado pela fórmula (i) ou sal farmaceuticamente aceitável do mesmo, ou solvato do mesmo, e uma substância básica, é excelente em dissolução, é estável mesmo após um longo tempo de estocagem, e é útil um agente preventivo ou terapêutico contra um tumor: (i) em que, r1 é um átomo de hidrogênio, um grupo c1-6 alquila ou um grupo c3-8 cicloaquila; e r2 é um átomo de hidrogênio ou um grupo metóxi.
BR112012003592A 2009-08-19 2010-08-16 composição farmacêutica contendo derivado de quinolina BR112012003592B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009190145 2009-08-19
JP2009-190145 2009-08-19
PCT/JP2010/063804 WO2011021597A1 (ja) 2009-08-19 2010-08-16 キノリン誘導体含有医薬組成物

Publications (3)

Publication Number Publication Date
BR112012003592A2 BR112012003592A2 (pt) 2016-03-15
BR112012003592B1 BR112012003592B1 (pt) 2020-11-03
BR112012003592B8 true BR112012003592B8 (pt) 2021-05-25

Family

ID=43607048

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012003592A BR112012003592B8 (pt) 2009-08-19 2010-08-16 composição farmacêutica contendo derivado de quinolina

Country Status (32)

Country Link
US (3) US20120077842A1 (pt)
EP (1) EP2468281B1 (pt)
JP (1) JP5048871B2 (pt)
KR (1) KR101496395B1 (pt)
CN (1) CN102470133B (pt)
AU (1) AU2010285740C1 (pt)
BR (1) BR112012003592B8 (pt)
CA (1) CA2771403C (pt)
CL (1) CL2012000412A1 (pt)
CO (1) CO6440512A2 (pt)
CY (1) CY1117481T1 (pt)
DK (1) DK2468281T3 (pt)
ES (1) ES2564797T3 (pt)
HK (2) HK1167607A1 (pt)
HR (1) HRP20160283T1 (pt)
HU (1) HUE026957T2 (pt)
IL (1) IL217197A (pt)
MA (1) MA33581B1 (pt)
ME (1) ME02359B (pt)
MX (2) MX344927B (pt)
MY (1) MY162940A (pt)
NZ (1) NZ598291A (pt)
PE (1) PE20121030A1 (pt)
PL (1) PL2468281T3 (pt)
RS (1) RS54686B1 (pt)
RU (1) RU2548673C3 (pt)
SG (1) SG178009A1 (pt)
SI (1) SI2468281T1 (pt)
SM (1) SMT201600077B (pt)
UA (1) UA105671C2 (pt)
WO (1) WO2011021597A1 (pt)
ZA (1) ZA201108697B (pt)

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JP4834553B2 (ja) 2004-09-17 2011-12-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 医薬組成物
JP4989476B2 (ja) * 2005-08-02 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を検定する方法
EP1938842A4 (en) * 2005-09-01 2013-01-09 Eisai R&D Man Co Ltd METHOD FOR PRODUCING A PHARMACEUTICAL COMPOSITION COMPRISING IMPROVED CRASHING CHARACTERISTICS
CN101316590B (zh) 2005-11-07 2011-08-03 卫材R&D管理有限公司 血管生成抑制剂和c-kit激酶抑制剂的组合使用
RU2448708C3 (ru) * 2006-05-18 2017-09-28 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Противоопухолевое средство против рака щитовидной железы
JP5368096B2 (ja) 2006-08-28 2013-12-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 未分化型胃癌に対する抗腫瘍剤
KR101445892B1 (ko) * 2007-01-29 2014-09-29 에자이 알앤드디 매니지먼트 가부시키가이샤 미분화형 위암 치료용 조성물
CA2704000C (en) * 2007-11-09 2016-12-13 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
US9012458B2 (en) 2010-06-25 2015-04-21 Eisai R&D Management Co., Ltd. Antitumor agent using compounds having kinase inhibitory effect in combination
CA2828946C (en) 2011-04-18 2016-06-21 Eisai R&D Management Co., Ltd. Therapeutic agent for tumor
ES2841809T3 (es) 2011-06-03 2021-07-09 Eisai R&D Man Co Ltd Biomarcadores para pronosticar y evaluar el grado de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
MX2015004979A (es) 2012-12-21 2015-07-17 Eisai R&D Man Co Ltd Forma amorfa de derivado de quinolina y metodo para su produccion.
AU2014266223B2 (en) 2013-05-14 2020-06-25 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
ES2926687T3 (es) 2014-08-28 2022-10-27 Eisai R&D Man Co Ltd Derivado de quinolina muy puro y método para su producción
CN106139156B (zh) * 2014-11-14 2019-01-29 江苏恒瑞医药股份有限公司 一种含有喹啉衍生物或其盐的药物组合物
HUE064614T2 (hu) * 2015-02-25 2024-04-28 Eisai R&D Man Co Ltd Eljárás egy kinolin-származék keserû ízének elnyomására
KR102662228B1 (ko) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
CN106075456A (zh) * 2015-04-27 2016-11-09 南京圣和药业股份有限公司 一种含乐伐替尼的药物组合物及其应用
WO2016184436A1 (zh) * 2015-05-21 2016-11-24 苏州晶云药物科技有限公司 乐伐替尼甲磺酸盐的新晶型及其制备方法
AU2016279474B2 (en) 2015-06-16 2021-09-09 Eisai R&D Management Co., Ltd. Anticancer agent
WO2017028660A1 (zh) * 2015-08-17 2017-02-23 江苏恒瑞医药股份有限公司 一种含有喹啉衍生物或其盐的药物组合物
RU2606592C1 (ru) * 2015-10-07 2017-01-10 Открытое Акционерное Общество "Татхимфармпрепараты" Фармацевтическая композиция, содержащая кальциевую соль розувастатина (варианты)
CZ2016240A3 (cs) 2016-04-27 2017-11-08 Zentiva, K.S. Soli lenvatinibu
EP3384901A1 (en) 2017-04-04 2018-10-10 Synthon B.V. Pharmaceutical composition comprising lenvatinib mesylate
US10583133B2 (en) 2018-03-12 2020-03-10 Shilpa Medicare Limited Pharmaceutical compositions of lenvatinib
CN110404079B (zh) * 2018-04-27 2023-01-24 北京睿创康泰医药研究院有限公司 一种不含碳酸盐、低基因毒性杂质含量的喹啉衍生物或其盐的药物组合物
EP3632436B1 (en) 2018-10-04 2022-04-20 Synthon B.V. Pharmaceutical composition comprising lenvatinib salts
MX2021003862A (es) * 2018-10-04 2021-05-27 Synthon Bv Formas cristalinas y procesos de besilato de lenvatinib.
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JP4749660B2 (ja) * 2002-10-16 2011-08-17 武田薬品工業株式会社 安定な固形製剤
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Also Published As

Publication number Publication date
IL217197A (en) 2016-08-31
RU2548673C3 (ru) 2018-07-20
RS54686B1 (en) 2016-08-31
SI2468281T1 (sl) 2016-05-31
UA105671C2 (uk) 2014-06-10
RU2548673C2 (ru) 2015-04-20
CN102470133B (zh) 2013-08-28
ES2564797T3 (es) 2016-03-29
PE20121030A1 (es) 2012-08-18
BR112012003592A2 (pt) 2016-03-15
PL2468281T3 (pl) 2016-06-30
ZA201108697B (en) 2012-07-25
EP2468281A1 (en) 2012-06-27
DK2468281T3 (en) 2016-03-21
US20120077842A1 (en) 2012-03-29
CY1117481T1 (el) 2017-04-26
EP2468281B1 (en) 2016-01-27
MY162940A (en) 2017-07-31
CL2012000412A1 (es) 2012-08-31
MX2012002011A (es) 2012-03-26
BR112012003592B1 (pt) 2020-11-03
IL217197A0 (en) 2012-02-29
CA2771403C (en) 2015-02-24
NZ598291A (en) 2013-02-22
US20210228722A1 (en) 2021-07-29
CO6440512A2 (es) 2012-05-15
EP2468281A4 (en) 2013-01-23
US20130296365A1 (en) 2013-11-07
KR101496395B1 (ko) 2015-02-26
SMT201600077B (it) 2016-04-29
HUE026957T2 (en) 2016-07-28
MA33581B1 (fr) 2012-09-01
CA2771403A1 (en) 2011-02-24
AU2010285740C1 (en) 2016-03-17
HK1167607A1 (en) 2012-12-07
AU2010285740B2 (en) 2014-12-04
CN102470133A (zh) 2012-05-23
MX344927B (es) 2017-01-11
AU2010285740A1 (en) 2011-12-15
SG178009A1 (en) 2012-03-29
RU2012103471A (ru) 2013-09-27
JPWO2011021597A1 (ja) 2013-01-24
HRP20160283T1 (hr) 2016-05-06
KR20120055559A (ko) 2012-05-31
WO2011021597A1 (ja) 2011-02-24
HK1169599A1 (zh) 2013-02-01
ME02359B (me) 2016-06-20
JP5048871B2 (ja) 2012-10-17

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
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