CY1117481T1 - Φαρμακευτικη συνθεση που περιεχει παραγωγο κινολινης - Google Patents

Φαρμακευτικη συνθεση που περιεχει παραγωγο κινολινης

Info

Publication number
CY1117481T1
CY1117481T1 CY20161100273T CY161100273T CY1117481T1 CY 1117481 T1 CY1117481 T1 CY 1117481T1 CY 20161100273 T CY20161100273 T CY 20161100273T CY 161100273 T CY161100273 T CY 161100273T CY 1117481 T1 CY1117481 T1 CY 1117481T1
Authority
CY
Cyprus
Prior art keywords
pharmaceutical composition
kinolin
product
composition containing
formula
Prior art date
Application number
CY20161100273T
Other languages
English (en)
Inventor
Masashi Bando
Original Assignee
Eisai R&D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43607048&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1117481(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai R&D Management Co., Ltd. filed Critical Eisai R&D Management Co., Ltd.
Publication of CY1117481T1 publication Critical patent/CY1117481T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Αποκαλύπτεται μια φαρμακευτική σύνθεση η οποία περιέχει: μια ένωση που αντιπροσωπεύεται από τον τύπο (I), ένα φαρμακολογικώς αποδεκτό άλας αυτής, ή ένα διαλύτωμα της ένωσης ή άλατος, και μια βασική ουσία. Η φαρμακευτική σύνθεση έχει εξαιρετική ικανότητα διαλύτωσης, είναι σταθερή ακόμη και μετά από μακροχρόνια αποθήκευση, και είναι χρήσιμη ως προφυλακτικός/θεραπευτικός παράγοντας για όγκους. (Στον τύπο, το R1 αντιπροσωπεύει ένα άτομο υδρογόνου, μια C1-6 αλκυλ ομάδα ή μια C3-8 κυκλοαλκυλ ομάδα, και το R2 αντιπροσωπεύει ένα άτομο υδρογόνου ή μια μεθοξυ ομάδα).
CY20161100273T 2009-08-19 2016-04-05 Φαρμακευτικη συνθεση που περιεχει παραγωγο κινολινης CY1117481T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009190145 2009-08-19
EP10809938.3A EP2468281B1 (en) 2009-08-19 2010-08-16 Quinoline derivative-containing pharmaceutical composition

Publications (1)

Publication Number Publication Date
CY1117481T1 true CY1117481T1 (el) 2017-04-26

Family

ID=43607048

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100273T CY1117481T1 (el) 2009-08-19 2016-04-05 Φαρμακευτικη συνθεση που περιεχει παραγωγο κινολινης

Country Status (33)

Country Link
US (3) US20120077842A1 (el)
EP (1) EP2468281B1 (el)
JP (1) JP5048871B2 (el)
KR (1) KR101496395B1 (el)
CN (1) CN102470133B (el)
AU (1) AU2010285740C1 (el)
BR (1) BR112012003592B8 (el)
CA (1) CA2771403C (el)
CL (1) CL2012000412A1 (el)
CO (1) CO6440512A2 (el)
CY (1) CY1117481T1 (el)
DK (1) DK2468281T3 (el)
ES (1) ES2564797T3 (el)
HK (2) HK1167607A1 (el)
HR (1) HRP20160283T1 (el)
HU (1) HUE026957T2 (el)
IL (1) IL217197A (el)
MA (1) MA33581B1 (el)
ME (1) ME02359B (el)
MX (2) MX2012002011A (el)
MY (1) MY162940A (el)
NZ (1) NZ598291A (el)
PE (1) PE20121030A1 (el)
PL (1) PL2468281T3 (el)
RS (1) RS54686B1 (el)
RU (1) RU2548673C3 (el)
SG (1) SG178009A1 (el)
SI (1) SI2468281T1 (el)
SM (1) SMT201600077B (el)
TH (1) TH121482A (el)
UA (1) UA105671C2 (el)
WO (1) WO2011021597A1 (el)
ZA (1) ZA201108697B (el)

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CN106139156B (zh) * 2014-11-14 2019-01-29 江苏恒瑞医药股份有限公司 一种含有喹啉衍生物或其盐的药物组合物
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KR102662228B1 (ko) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
CN106075456A (zh) * 2015-04-27 2016-11-09 南京圣和药业股份有限公司 一种含乐伐替尼的药物组合物及其应用
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Also Published As

Publication number Publication date
CO6440512A2 (es) 2012-05-15
RS54686B1 (en) 2016-08-31
AU2010285740C1 (en) 2016-03-17
KR20120055559A (ko) 2012-05-31
RU2012103471A (ru) 2013-09-27
CN102470133B (zh) 2013-08-28
RU2548673C2 (ru) 2015-04-20
HRP20160283T1 (hr) 2016-05-06
BR112012003592B1 (pt) 2020-11-03
JP5048871B2 (ja) 2012-10-17
SI2468281T1 (sl) 2016-05-31
TH121482A (th) 2013-02-28
BR112012003592B8 (pt) 2021-05-25
JPWO2011021597A1 (ja) 2013-01-24
RU2548673C3 (ru) 2018-07-20
SG178009A1 (en) 2012-03-29
US20210228722A1 (en) 2021-07-29
AU2010285740B2 (en) 2014-12-04
HK1169599A1 (zh) 2013-02-01
KR101496395B1 (ko) 2015-02-26
CA2771403A1 (en) 2011-02-24
AU2010285740A1 (en) 2011-12-15
US20130296365A1 (en) 2013-11-07
HK1167607A1 (en) 2012-12-07
CL2012000412A1 (es) 2012-08-31
DK2468281T3 (en) 2016-03-21
ES2564797T3 (es) 2016-03-29
IL217197A (en) 2016-08-31
MX344927B (es) 2017-01-11
EP2468281B1 (en) 2016-01-27
UA105671C2 (uk) 2014-06-10
ME02359B (me) 2016-06-20
MA33581B1 (fr) 2012-09-01
IL217197A0 (en) 2012-02-29
EP2468281A1 (en) 2012-06-27
SMT201600077B (it) 2016-04-29
WO2011021597A1 (ja) 2011-02-24
CN102470133A (zh) 2012-05-23
NZ598291A (en) 2013-02-22
US20120077842A1 (en) 2012-03-29
PL2468281T3 (pl) 2016-06-30
BR112012003592A2 (pt) 2016-03-15
EP2468281A4 (en) 2013-01-23
CA2771403C (en) 2015-02-24
MX2012002011A (es) 2012-03-26
PE20121030A1 (es) 2012-08-18
ZA201108697B (en) 2012-07-25
MY162940A (en) 2017-07-31
HUE026957T2 (en) 2016-07-28

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