CU24030B1 - Nuevos derivados de benzotiadiazepinas, su procedimiento de preparación y composiciones farmacéuticas que los contienen - Google Patents

Nuevos derivados de benzotiadiazepinas, su procedimiento de preparación y composiciones farmacéuticas que los contienen

Info

Publication number
CU24030B1
CU24030B1 CU2011000169A CU20110169A CU24030B1 CU 24030 B1 CU24030 B1 CU 24030B1 CU 2011000169 A CU2011000169 A CU 2011000169A CU 20110169 A CU20110169 A CU 20110169A CU 24030 B1 CU24030 B1 CU 24030B1
Authority
CU
Cuba
Prior art keywords
pharmaceutical compositions
compositions containing
benzotiadiazepinas
group
preparation procedure
Prior art date
Application number
CU2011000169A
Other languages
English (en)
Other versions
CU20110169A7 (es
Inventor
Alexis Cordi
Patrice Desos
Pierre Lestage
Laurence Danober
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of CU20110169A7 publication Critical patent/CU20110169A7/es
Publication of CU24030B1 publication Critical patent/CU24030B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compuestos de Fórmula (I): en la que: R1 representa un átomo de hidrógeno o un grupo oxicarbonilo, un grupo hidroxi, un grupo hidrometilo, un grupo amino o un grupo N-metiaminocarbonilo, R2 representan un átomo de hidrógeno, R3 representa un átomo de hidrógeno o un grupo metilo, R4 representa un átomo de hidrógeno, su procedimiento de preparación y composiciones farmacéuticas que los contienen. Medicamentos.
CU2011000169A 2009-03-20 2011-09-07 Nuevos derivados de benzotiadiazepinas, su procedimiento de preparación y composiciones farmacéuticas que los contienen CU24030B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0901300A FR2943342B1 (fr) 2009-03-20 2009-03-20 Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
PCT/FR2010/000227 WO2010106249A1 (fr) 2009-03-20 2010-03-18 Derives de benzothiadiazepines en tant que modulateures des recepteurs ampa et nmda

Publications (2)

Publication Number Publication Date
CU20110169A7 CU20110169A7 (es) 2012-02-15
CU24030B1 true CU24030B1 (es) 2014-10-02

Family

ID=40863576

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2011000169A CU24030B1 (es) 2009-03-20 2011-09-07 Nuevos derivados de benzotiadiazepinas, su procedimiento de preparación y composiciones farmacéuticas que los contienen

Country Status (45)

Country Link
US (1) US8236790B2 (es)
EP (1) EP2246339B1 (es)
JP (1) JP5437473B2 (es)
KR (1) KR101431504B1 (es)
CN (1) CN102361860B (es)
AP (1) AP3050A (es)
AR (1) AR075892A1 (es)
AT (1) ATE513822T1 (es)
AU (1) AU2010200815B2 (es)
BR (1) BRPI1009200A2 (es)
CA (1) CA2696705C (es)
CL (1) CL2011002287A1 (es)
CO (1) CO6361956A2 (es)
CR (1) CR20110484A (es)
CU (1) CU24030B1 (es)
CY (1) CY1111807T1 (es)
DK (1) DK2246339T3 (es)
EA (1) EA020259B1 (es)
EC (1) ECSP11011340A (es)
ES (1) ES2368691T3 (es)
FR (1) FR2943342B1 (es)
GE (1) GEP20135862B (es)
HK (1) HK1167404A1 (es)
HN (1) HN2011002458A (es)
HR (1) HRP20110626T1 (es)
IL (1) IL215016A (es)
JO (1) JO2780B1 (es)
MA (1) MA33131B1 (es)
MX (1) MX2011009638A (es)
MY (1) MY154001A (es)
NI (1) NI201100169A (es)
NZ (1) NZ595082A (es)
PE (1) PE20120113A1 (es)
PL (1) PL2246339T3 (es)
PT (1) PT2246339E (es)
RS (1) RS51919B (es)
SA (1) SA110310217B1 (es)
SG (1) SG174274A1 (es)
SI (1) SI2246339T1 (es)
TN (1) TN2011000469A1 (es)
TW (1) TWI388326B (es)
UA (1) UA100477C2 (es)
UY (1) UY32475A (es)
WO (1) WO2010106249A1 (es)
ZA (1) ZA201001905B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2464645T (pt) * 2009-07-27 2017-10-11 Gilead Sciences Inc Compostos heterocíclicos fusionados como moduladores do canal de iões
BR112012033402A2 (pt) 2010-07-02 2017-01-24 Gilead Sciences Inc moduladores de canais de íons conforme os compostos heterocíclicos fundidos
WO2012020848A1 (en) 2010-08-10 2012-02-16 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
BR112013028886A2 (pt) 2011-05-10 2016-08-09 Gilead Sciences Inc compostos heterocíclicos fundidos como moduladores dde canal de sódio
AU2015224425B2 (en) * 2011-07-01 2017-02-09 Gilead Sciences, Inc. Fused benzoxazepinones as ion channel modulators
NO3175985T3 (es) 2011-07-01 2018-04-28
UY34171A (es) 2011-07-01 2013-01-31 Gilead Sciences Inc Compuestos heterocíclicos fusionados como moduladores del canal iónico
JP6134654B2 (ja) 2012-02-08 2017-05-24 武田薬品工業株式会社 複素環化合物およびその用途
CN111518055A (zh) * 2020-05-16 2020-08-11 西安都创医药科技有限公司 一种苯并硫氮杂卓氧化物的制备方法及其制备的产品及其应用
CN111548325A (zh) * 2020-05-16 2020-08-18 西安都创医药科技有限公司 一种卤代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111620838A (zh) * 2020-05-16 2020-09-04 西安都创医药科技有限公司 一种氯代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111574475B (zh) * 2020-06-03 2022-09-20 西安都创医药科技有限公司 卤代苯并硫杂卓氧化物的制备方法及其制备的产品及其应用
CN115368363B (zh) * 2021-05-17 2024-02-20 中山大学 一种手性或消旋的嘧啶并二氮杂环庚酮类化合物及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3957093A (en) * 1992-04-15 1993-11-18 Rhone-Poulenc Rorer S.A. 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide-3-carboxyl ic acid derivatives, preparation thereof and drugs containing same
AU2594799A (en) * 1998-02-11 1999-08-30 Du Pont Pharmaceuticals Company Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors
ZA991301B (en) * 1998-02-18 1999-09-13 Neurosearch As Glutamate receptor modulators.
US6156746A (en) * 1998-08-25 2000-12-05 Bristol-Myers Squibb Company 1,2,5-benzothiadiazepine-1,1-dioxides with n-2 imidazolylalkyl substituents
GB0209467D0 (en) * 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
DE10300973A1 (de) * 2003-01-14 2004-07-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Carbonsäuren und deren Ester, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2877338B1 (fr) * 2004-11-03 2007-01-26 Servier Lab Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2879201B1 (fr) * 2004-12-10 2007-02-16 Servier Lab Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
RS51919B (en) 2012-02-29
UY32475A (es) 2010-09-30
AP3050A (en) 2014-11-30
IL215016A0 (en) 2011-11-30
CN102361860B (zh) 2014-09-10
ZA201001905B (en) 2010-11-24
EA020259B1 (ru) 2014-09-30
ATE513822T1 (de) 2011-07-15
CY1111807T1 (el) 2015-10-07
TN2011000469A1 (fr) 2013-03-27
GEP20135862B (en) 2013-06-25
ES2368691T3 (es) 2011-11-21
CN102361860A (zh) 2012-02-22
WO2010106249A1 (fr) 2010-09-23
MA33131B1 (fr) 2012-03-01
JP5437473B2 (ja) 2014-03-12
US8236790B2 (en) 2012-08-07
KR20110128209A (ko) 2011-11-28
MX2011009638A (es) 2011-09-28
CR20110484A (es) 2011-10-24
MY154001A (en) 2015-04-30
UA100477C2 (uk) 2012-12-25
SA110310217B1 (ar) 2013-06-15
EP2246339A1 (fr) 2010-11-03
AU2010200815A1 (en) 2010-10-07
HK1167404A1 (en) 2012-11-30
AR075892A1 (es) 2011-05-04
CL2011002287A1 (es) 2012-02-03
AP2011005935A0 (en) 2011-10-31
CU20110169A7 (es) 2012-02-15
US20100240635A1 (en) 2010-09-23
TW201036615A (en) 2010-10-16
SI2246339T1 (sl) 2011-09-30
EP2246339B1 (fr) 2011-06-22
HN2011002458A (es) 2014-05-19
NZ595082A (en) 2013-12-20
FR2943342B1 (fr) 2011-03-04
CA2696705C (fr) 2013-02-12
ECSP11011340A (es) 2011-10-31
JP2012520858A (ja) 2012-09-10
PT2246339E (pt) 2011-08-01
CA2696705A1 (fr) 2010-09-20
JO2780B1 (en) 2014-03-15
EA201101334A1 (ru) 2012-04-30
HRP20110626T1 (hr) 2011-10-31
PE20120113A1 (es) 2012-02-24
NI201100169A (es) 2012-01-11
AU2010200815B2 (en) 2015-05-07
SG174274A1 (en) 2011-10-28
CO6361956A2 (es) 2012-01-20
TWI388326B (zh) 2013-03-11
BRPI1009200A2 (pt) 2017-06-13
KR101431504B1 (ko) 2014-08-20
FR2943342A1 (fr) 2010-09-24
DK2246339T3 (da) 2011-10-10
IL215016A (en) 2013-08-29
PL2246339T3 (pl) 2011-11-30

Similar Documents

Publication Publication Date Title
CU24030B1 (es) Nuevos derivados de benzotiadiazepinas, su procedimiento de preparación y composiciones farmacéuticas que los contienen
EA200701176A1 (ru) Новые соединения нафталина, способ их получения и фармацевтические композиции, содержащие их
SV2009003199A (es) Nuevos derivados de diosmetina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
UY31639A1 (es) Derivados de amida espirocíclica de fórmula i, sales farmacéuticamente aceptables, composiciones farmacéuticas conteniéndolas, procesos de preparación y aplicaciones
CR20110579A (es) Compuestos 1-cianoetilheterociclilcarboxamida sustituidos 750
UY31906A (es) Derivados de n-cicloalquil-3-fenilnicotinamida que inhiben pgds, sus composiciones, su uso para el tratamiento por ejemplo de afecciones alérgicas y respiratorias.
CU20100157A7 (es) Nuevos derivados dihidroindolonas, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
UY29510A1 (es) Derivados de urea, metodos para su fabricación, y usos de los mismos
PA8768301A1 (es) Nuevos derivados tricíclicos, su procedimiento de preparación y las composiciones farmacéuticas que lo contienen
ECSP099679A (es) Nuevos compuestos y sus usos 707
AR077429A1 (es) Compuestos hidroxiasenapina sus derivados y composiciones farmaceuticas que comprenden los mismos
UY32702A (es) Nuevos derivados de ácido 2-mercaptociclopentanocarboxílico, su procedimiento de preparación y las composiciones farmacéuticas que los contienen.
CU20120041A7 (es) Nuevos derivados dihidro-oxazolobenzodiazepinonas, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
CU20130037A7 (es) Nuevos derivados dihidrobenzoxatiazepinas, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
UA91646C2 (ru) Соединения индола, способ их получения и фармацевтическая композиция (варианты), которая их содержит
EA200601248A1 (ru) Новые многократно замещённые соединения 1,1-пиридилоксициклопропанамина, способ их получения и фармацевтические композиции, которые их содержат
SV2010003626A (es) Nuevos compuestos piperidinicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
UY30343A1 (es) Derivados de 1,2,3,4-tetrahidro-quinolina como inhibidores de cetp
AR078181A1 (es) Derivados acetilenicos de 5-fenilpirazolopiridina, su preparacion y su aplicacion terapeutica en enfermedades mediadas por los receptores nucleares nurr-1

Legal Events

Date Code Title Description
FG Grant of patent