NI201100169A - Derivados de benzotiadiazepinas usados como moduladores de receptores ampa y nmda - Google Patents

Derivados de benzotiadiazepinas usados como moduladores de receptores ampa y nmda

Info

Publication number
NI201100169A
NI201100169A NI201100169A NI201100169A NI201100169A NI 201100169 A NI201100169 A NI 201100169A NI 201100169 A NI201100169 A NI 201100169A NI 201100169 A NI201100169 A NI 201100169A NI 201100169 A NI201100169 A NI 201100169A
Authority
NI
Nicaragua
Prior art keywords
benzotiadiazepine
ampa
modulators
nmda receptors
derivatives used
Prior art date
Application number
NI201100169A
Other languages
English (en)
Inventor
Desos Patrice
Lestage Pierre
Cordis Alexis
Danober Laurence
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of NI201100169A publication Critical patent/NI201100169A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compuestos de fórmula (I) : en la que : R1 y R2, idénticos o diferentes, representan cada uno un átomo de hidrógeno o de halógeno, o un grupo alquilo, alcoxi, alquiltio, acilo, alcoxicarbonilo, carboxi, hidroxi, hidroxialquilo, ciano, nitro, amino, aminocarbonilo sustituido o no, aminosulfonilo, alquilsulfonilaminoalquilo, N-hidroxicarboximidamida o benciloxi; R3 representa un átomo de hidrógeno o un grupo alquilo, cicloalquilo o cicloalquilalquilo; R4 representa un átomo de hidrógeno o un grupo alquilo sustituido o no. Medicamentos.
NI201100169A 2009-03-20 2011-09-13 Derivados de benzotiadiazepinas usados como moduladores de receptores ampa y nmda NI201100169A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0901300A FR2943342B1 (fr) 2009-03-20 2009-03-20 Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
NI201100169A true NI201100169A (es) 2012-01-11

Family

ID=40863576

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201100169A NI201100169A (es) 2009-03-20 2011-09-13 Derivados de benzotiadiazepinas usados como moduladores de receptores ampa y nmda

Country Status (45)

Country Link
US (1) US8236790B2 (es)
EP (1) EP2246339B1 (es)
JP (1) JP5437473B2 (es)
KR (1) KR101431504B1 (es)
CN (1) CN102361860B (es)
AP (1) AP3050A (es)
AR (1) AR075892A1 (es)
AT (1) ATE513822T1 (es)
AU (1) AU2010200815B2 (es)
BR (1) BRPI1009200A2 (es)
CA (1) CA2696705C (es)
CL (1) CL2011002287A1 (es)
CO (1) CO6361956A2 (es)
CR (1) CR20110484A (es)
CU (1) CU24030B1 (es)
CY (1) CY1111807T1 (es)
DK (1) DK2246339T3 (es)
EA (1) EA020259B1 (es)
EC (1) ECSP11011340A (es)
ES (1) ES2368691T3 (es)
FR (1) FR2943342B1 (es)
GE (1) GEP20135862B (es)
HK (1) HK1167404A1 (es)
HN (1) HN2011002458A (es)
HR (1) HRP20110626T1 (es)
IL (1) IL215016A (es)
JO (1) JO2780B1 (es)
MA (1) MA33131B1 (es)
MX (1) MX2011009638A (es)
MY (1) MY154001A (es)
NI (1) NI201100169A (es)
NZ (1) NZ595082A (es)
PE (1) PE20120113A1 (es)
PL (1) PL2246339T3 (es)
PT (1) PT2246339E (es)
RS (1) RS51919B (es)
SA (1) SA110310217B1 (es)
SG (1) SG174274A1 (es)
SI (1) SI2246339T1 (es)
TN (1) TN2011000469A1 (es)
TW (1) TWI388326B (es)
UA (1) UA100477C2 (es)
UY (1) UY32475A (es)
WO (1) WO2010106249A1 (es)
ZA (1) ZA201001905B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2464645T3 (en) * 2009-07-27 2017-10-23 Gilead Sciences Inc CONDENSED, HETEROCYCLIC COMPOUNDS AS IRON CHANNEL MODULATORS
MX2012015096A (es) 2010-07-02 2013-05-28 Gilead Sciences Inc Compuestos heterociclicos fusionados como moduladores del canal ion.
PT2603513T (pt) 2010-08-10 2020-06-08 Takeda Pharmaceuticals Co Composto heterocíclico e sua utilização como modulador alostérico positivo do recetor de ampa
AU2012253653A1 (en) 2011-05-10 2013-05-02 Gilead Sciences, Inc. Fused heterocyclic compounds as sodium channel modulators
AU2015224425B2 (en) * 2011-07-01 2017-02-09 Gilead Sciences, Inc. Fused benzoxazepinones as ion channel modulators
UY34171A (es) * 2011-07-01 2013-01-31 Gilead Sciences Inc Compuestos heterocíclicos fusionados como moduladores del canal iónico
NO3175985T3 (es) 2011-07-01 2018-04-28
US9493484B2 (en) 2012-02-08 2016-11-15 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
CN111620838A (zh) * 2020-05-16 2020-09-04 西安都创医药科技有限公司 一种氯代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111518055A (zh) * 2020-05-16 2020-08-11 西安都创医药科技有限公司 一种苯并硫氮杂卓氧化物的制备方法及其制备的产品及其应用
CN111548325A (zh) * 2020-05-16 2020-08-18 西安都创医药科技有限公司 一种卤代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111574475B (zh) * 2020-06-03 2022-09-20 西安都创医药科技有限公司 卤代苯并硫杂卓氧化物的制备方法及其制备的产品及其应用
CN115368363B (zh) * 2021-05-17 2024-02-20 中山大学 一种手性或消旋的嘧啶并二氮杂环庚酮类化合物及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0636124A1 (fr) * 1992-04-15 1995-02-01 Aventis Pharma S.A. Derives d'acide 3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxyde-3-carboxylique, leur preparation et les medicaments les contenant
WO1999041246A1 (en) * 1998-02-11 1999-08-19 Du Pont Pharmaceuticals Company Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors
IL137720A0 (en) * 1998-02-18 2001-10-31 Neurosearch As Compounds and their use as positive ampa receptor modulators
US6156746A (en) * 1998-08-25 2000-12-05 Bristol-Myers Squibb Company 1,2,5-benzothiadiazepine-1,1-dioxides with n-2 imidazolylalkyl substituents
GB0209467D0 (en) * 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
DE10300973A1 (de) * 2003-01-14 2004-07-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Carbonsäuren und deren Ester, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2877338B1 (fr) * 2004-11-03 2007-01-26 Servier Lab Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2879201B1 (fr) * 2004-12-10 2007-02-16 Servier Lab Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
TWI388326B (zh) 2013-03-11
PE20120113A1 (es) 2012-02-24
AU2010200815B2 (en) 2015-05-07
CN102361860B (zh) 2014-09-10
ZA201001905B (en) 2010-11-24
CY1111807T1 (el) 2015-10-07
AU2010200815A1 (en) 2010-10-07
EP2246339A1 (fr) 2010-11-03
EA201101334A1 (ru) 2012-04-30
HRP20110626T1 (hr) 2011-10-31
JO2780B1 (en) 2014-03-15
TN2011000469A1 (fr) 2013-03-27
IL215016A0 (en) 2011-11-30
CR20110484A (es) 2011-10-24
FR2943342B1 (fr) 2011-03-04
SA110310217B1 (ar) 2013-06-15
CN102361860A (zh) 2012-02-22
CA2696705C (fr) 2013-02-12
AP3050A (en) 2014-11-30
CU24030B1 (es) 2014-10-02
AP2011005935A0 (en) 2011-10-31
EP2246339B1 (fr) 2011-06-22
HK1167404A1 (en) 2012-11-30
BRPI1009200A2 (pt) 2017-06-13
CA2696705A1 (fr) 2010-09-20
DK2246339T3 (da) 2011-10-10
HN2011002458A (es) 2014-05-19
IL215016A (en) 2013-08-29
SI2246339T1 (sl) 2011-09-30
WO2010106249A1 (fr) 2010-09-23
CO6361956A2 (es) 2012-01-20
GEP20135862B (en) 2013-06-25
ECSP11011340A (es) 2011-10-31
AR075892A1 (es) 2011-05-04
KR20110128209A (ko) 2011-11-28
MA33131B1 (fr) 2012-03-01
CU20110169A7 (es) 2012-02-15
FR2943342A1 (fr) 2010-09-24
UY32475A (es) 2010-09-30
MY154001A (en) 2015-04-30
SG174274A1 (en) 2011-10-28
CL2011002287A1 (es) 2012-02-03
NZ595082A (en) 2013-12-20
MX2011009638A (es) 2011-09-28
ES2368691T3 (es) 2011-11-21
RS51919B (en) 2012-02-29
JP5437473B2 (ja) 2014-03-12
US8236790B2 (en) 2012-08-07
EA020259B1 (ru) 2014-09-30
ATE513822T1 (de) 2011-07-15
PT2246339E (pt) 2011-08-01
JP2012520858A (ja) 2012-09-10
PL2246339T3 (pl) 2011-11-30
KR101431504B1 (ko) 2014-08-20
US20100240635A1 (en) 2010-09-23
UA100477C2 (uk) 2012-12-25
TW201036615A (en) 2010-10-16

Similar Documents

Publication Publication Date Title
NI201100169A (es) Derivados de benzotiadiazepinas usados como moduladores de receptores ampa y nmda
HN2009001165A (es) Derivados de dihidropiridina de utilidad como inhibidores de la proteina quinasa
UY29337A1 (es) N-aminometilensulfonamidas sustituidas, su preparación y su uso como medicamentos.
CO6390057A2 (es) Indazoles oxazol sustituidos como inhibidores de pi3-quinasa
GT200800251A (es) Nitrilos espirociclicos como inhibidores de proteasa
CR20110028A (es) Derivados de pirimidina como inhibidores de cinasa
CR20120334A (es) Derivados de imidazopiridina como inhibidores de jak
UY28186A1 (es) N-arilheterociclos sustituidos, procedimientos para su preparación, y su empleo como medicamentos.
NI200900042A (es) Nuevo derivados de dismetina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen.
CU23840B1 (es) Nuevos derivados de sulfonamida como antagonistas de la bradiquinina
EA200870197A1 (ru) Новые 2-замещённые бензимидазолы в качестве селективных модуляторов рецептора андрогена (sarms)
CO6470826A2 (es) Moduladores de lxr
NI200900155A (es) COMPUESTOS DE 2-AMINO PIRIMIDINA. Caso: PC 33441A
MX2010002899A (es) Derivados de azaciclilisoquinolinona e isoindolinona como antagonistas de la histamina-3.
NO20084007L (no) Spirokondenserte piperidiner som modulatorer av muskarinreseptorer
UY30534A1 (es) Derivados de 5,6-bisaril-2-piridin-carboxamida, su preparacion y su aplicacion en terapéutica como antagonistas de los receptores de urotensina ii
EA201200891A1 (ru) Производные 3,4,4a,10d-тетрагидро-1h-тиопирано[4,3-c]изохинолина
CR20130541A (es) Derivados de 2-amino-3-(imidazol-2-il)-piridin-4-ona, y su uso como receptores vegf de inhibidores de cinasa
UY31487A1 (es) Derivados de pirazol como inhibidores de 5-lo
CO7160116A2 (es) Derivados de pirimidinona como agentes antimalaricos
NI201300028A (es) Nuevos derivados dihidrobenzoxatiazepinas, su procedimiento de preparación y las composiciones farmacéuticas que los contienen.
CR11566A (es) Nuevos derivados cromenicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
NI201200039A (es) Nuevos derivados dihidro - oxazolobenzodiazepinonas, su procedi
AR077683A1 (es) Uso de 1,2,4- triazindionas heterociclicas sustituidas
CR11790A (es) Derivados de quinuclidina como antagonistas de receptores muscarinicos m3