CU23840B1 - Nuevos derivados de sulfonamida como antagonistas de la bradiquinina - Google Patents
Nuevos derivados de sulfonamida como antagonistas de la bradiquininaInfo
- Publication number
- CU23840B1 CU23840B1 CU2009000070A CU20090070A CU23840B1 CU 23840 B1 CU23840 B1 CU 23840B1 CU 2009000070 A CU2009000070 A CU 2009000070A CU 20090070 A CU20090070 A CU 20090070A CU 23840 B1 CU23840 B1 CU 23840B1
- Authority
- CU
- Cuba
- Prior art keywords
- bradiquinina
- sulfonamide
- antagonists
- new derivatives
- formula
- Prior art date
Links
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- 150000003456 sulfonamides Chemical class 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008196 pharmacological composition Substances 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract
La presente invención se refiere a nuevos derivados de sulfonamida de fórmula (I) ESPACIO PARA FÓRMULA donde R1-R5 y Z son como se definen en las reivindicaciones, a procesos para producir los compuestos de fórmula (I) y a las composiciones farmacológicas que los contienen.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0600810A HUP0600810A3 (en) | 2006-10-27 | 2006-10-27 | New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them |
PCT/HU2007/000104 WO2008050168A1 (en) | 2006-10-27 | 2007-10-27 | New sulfonamide derivatives as bradykinin antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20090070A7 CU20090070A7 (es) | 2011-05-27 |
CU23840B1 true CU23840B1 (es) | 2012-10-15 |
Family
ID=89987107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2009000070A CU23840B1 (es) | 2006-10-27 | 2009-04-27 | Nuevos derivados de sulfonamida como antagonistas de la bradiquinina |
Country Status (20)
Country | Link |
---|---|
US (1) | US20100075978A1 (es) |
EP (1) | EP2074083B1 (es) |
JP (1) | JP2010507644A (es) |
KR (1) | KR20090076927A (es) |
CN (1) | CN101528681B (es) |
AU (1) | AU2007310588B2 (es) |
BR (1) | BRPI0718495A2 (es) |
CA (1) | CA2667285C (es) |
CU (1) | CU23840B1 (es) |
EA (1) | EA018046B1 (es) |
GE (1) | GEP20125437B (es) |
HU (1) | HUP0600810A3 (es) |
IL (1) | IL198345A0 (es) |
MA (1) | MA30911B1 (es) |
MX (1) | MX2009004527A (es) |
MY (1) | MY148076A (es) |
NO (1) | NO20092050L (es) |
NZ (1) | NZ575762A (es) |
TN (1) | TN2009000107A1 (es) |
WO (1) | WO2008050168A1 (es) |
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WO2009053763A1 (en) * | 2007-10-27 | 2009-04-30 | Richter Gedeon Nyrt. | New non-peptide derivatives as bradykinin bl antagonists |
AU2009282822A1 (en) * | 2008-08-21 | 2010-02-25 | Richter Gedeon Nyrt. | Methods for treating CNS disorders |
EP2330899A1 (en) * | 2008-08-21 | 2011-06-15 | Richter Gedeon Nyrt. | Methods for treating neuropathic pain |
JP6067226B2 (ja) | 2009-03-13 | 2017-01-25 | アジオス ファーマシューティカルズ, インコーポレイテッド | 細胞増殖関連疾患のための方法および組成物 |
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CN108451955B (zh) | 2011-05-03 | 2022-02-01 | 安吉奥斯医药品有限公司 | 用于治疗的丙酮酸激酶活化剂 |
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CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
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US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
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US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
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JP6529492B2 (ja) | 2013-07-11 | 2019-06-12 | アジオス ファーマシューティカルズ, インコーポレイテッド | 癌の処置のためのidh2突然変異体阻害剤としての2,4−または4,6−ジアミノピリミジン化合物 |
US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
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KR20240010105A (ko) | 2014-03-14 | 2024-01-23 | 아지오스 파마슈티컬스 아이엔씨. | 치료적으로 활성인 화합물의 약제학적 조성물 |
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HUP0600808A3 (en) * | 2006-10-27 | 2008-09-29 | Richter Gedeon Nyrt | New benzamide derivatives as bradykinin antagonists, process for their preparation and pharmaceutical compositions containing them |
HUP0600809A3 (en) * | 2006-10-27 | 2008-09-29 | Richter Gedeon Nyrt | New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them |
WO2009053763A1 (en) * | 2007-10-27 | 2009-04-30 | Richter Gedeon Nyrt. | New non-peptide derivatives as bradykinin bl antagonists |
AU2009282822A1 (en) * | 2008-08-21 | 2010-02-25 | Richter Gedeon Nyrt. | Methods for treating CNS disorders |
EP2330899A1 (en) * | 2008-08-21 | 2011-06-15 | Richter Gedeon Nyrt. | Methods for treating neuropathic pain |
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2006
- 2006-10-27 HU HU0600810A patent/HUP0600810A3/hu unknown
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2007
- 2007-10-27 AU AU2007310588A patent/AU2007310588B2/en not_active Ceased
- 2007-10-27 EA EA200900606A patent/EA018046B1/ru not_active IP Right Cessation
- 2007-10-27 JP JP2009533966A patent/JP2010507644A/ja active Pending
- 2007-10-27 WO PCT/HU2007/000104 patent/WO2008050168A1/en active Application Filing
- 2007-10-27 US US12/447,132 patent/US20100075978A1/en not_active Abandoned
- 2007-10-27 GE GEAP200711270A patent/GEP20125437B/en unknown
- 2007-10-27 MX MX2009004527A patent/MX2009004527A/es active IP Right Grant
- 2007-10-27 CN CN2007800400106A patent/CN101528681B/zh not_active Expired - Fee Related
- 2007-10-27 CA CA2667285A patent/CA2667285C/en not_active Expired - Fee Related
- 2007-10-27 BR BRPI0718495-6A patent/BRPI0718495A2/pt not_active IP Right Cessation
- 2007-10-27 EP EP07824996.8A patent/EP2074083B1/en active Active
- 2007-10-27 NZ NZ575762A patent/NZ575762A/en not_active IP Right Cessation
- 2007-10-27 KR KR1020097008095A patent/KR20090076927A/ko not_active Application Discontinuation
- 2007-10-27 MY MYPI20091576A patent/MY148076A/en unknown
-
2009
- 2009-03-30 TN TN2009000107A patent/TN2009000107A1/fr unknown
- 2009-04-23 IL IL198345A patent/IL198345A0/en unknown
- 2009-04-27 CU CU2009000070A patent/CU23840B1/es not_active IP Right Cessation
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Also Published As
Publication number | Publication date |
---|---|
AU2007310588B2 (en) | 2012-08-23 |
EP2074083B1 (en) | 2013-06-19 |
MA30911B1 (fr) | 2009-11-02 |
MY148076A (en) | 2013-02-28 |
CN101528681A (zh) | 2009-09-09 |
HU0600810D0 (en) | 2006-12-28 |
CA2667285A1 (en) | 2008-05-02 |
WO2008050168A8 (en) | 2009-04-09 |
HUP0600810A2 (en) | 2008-08-28 |
CN101528681B (zh) | 2013-01-30 |
WO2008050168A1 (en) | 2008-05-02 |
NO20092050L (no) | 2009-07-17 |
IL198345A0 (en) | 2010-02-17 |
EA200900606A1 (ru) | 2009-08-28 |
AU2007310588A1 (en) | 2008-05-02 |
BRPI0718495A2 (pt) | 2013-12-03 |
US20100075978A1 (en) | 2010-03-25 |
CA2667285C (en) | 2012-09-25 |
EP2074083A1 (en) | 2009-07-01 |
NZ575762A (en) | 2011-12-22 |
TN2009000107A1 (en) | 2010-08-19 |
EA018046B1 (ru) | 2013-05-30 |
JP2010507644A (ja) | 2010-03-11 |
CU20090070A7 (es) | 2011-05-27 |
KR20090076927A (ko) | 2009-07-13 |
MX2009004527A (es) | 2009-07-02 |
GEP20125437B (en) | 2012-03-26 |
HUP0600810A3 (en) | 2008-09-29 |
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