MA44392B1 - Procédés d'utilisation d'activateurs de la pyruvate kinase - Google Patents

Procédés d'utilisation d'activateurs de la pyruvate kinase

Info

Publication number
MA44392B1
MA44392B1 MA44392A MA44392A MA44392B1 MA 44392 B1 MA44392 B1 MA 44392B1 MA 44392 A MA44392 A MA 44392A MA 44392 A MA44392 A MA 44392A MA 44392 B1 MA44392 B1 MA 44392B1
Authority
MA
Morocco
Prior art keywords
methods
pyruvate kinase
kinase activators
activators
pyruvate
Prior art date
Application number
MA44392A
Other languages
English (en)
Other versions
MA44392A (fr
Inventor
Samuel Agresta
Yue Chen
Marvin Cohen
Leonard Luan Dang
Charles Kung
Elizabeth Merica
Bruce Silver
Hua Yang
Original Assignee
Agios Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agios Pharmaceuticals Inc filed Critical Agios Pharmaceuticals Inc
Publication of MA44392A publication Critical patent/MA44392A/fr
Publication of MA44392B1 publication Critical patent/MA44392B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La présente invention a pour objet des méthodes d'utilisation de composés qui activent la pyruvate kinase.
MA44392A 2015-06-11 2016-06-10 Procédés d'utilisation d'activateurs de la pyruvate kinase MA44392B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562174216P 2015-06-11 2015-06-11
PCT/US2016/036893 WO2016201227A1 (fr) 2015-06-11 2016-06-10 Procédés d'utilisation d'activateurs de la pyruvate kinase

Publications (2)

Publication Number Publication Date
MA44392A MA44392A (fr) 2019-01-23
MA44392B1 true MA44392B1 (fr) 2023-10-31

Family

ID=57504271

Family Applications (1)

Application Number Title Priority Date Filing Date
MA44392A MA44392B1 (fr) 2015-06-11 2016-06-10 Procédés d'utilisation d'activateurs de la pyruvate kinase

Country Status (20)

Country Link
US (2) US11234976B2 (fr)
EP (2) EP4344703A1 (fr)
JP (3) JP7320339B2 (fr)
AU (2) AU2016276951B2 (fr)
CA (1) CA2989111C (fr)
DK (1) DK3307271T3 (fr)
ES (1) ES2959690T3 (fr)
FI (1) FI3307271T3 (fr)
HK (1) HK1253727A1 (fr)
HR (1) HRP20231247T1 (fr)
HU (1) HUE063541T2 (fr)
LT (1) LT3307271T (fr)
MA (1) MA44392B1 (fr)
MD (1) MD3307271T2 (fr)
MX (1) MX2017016041A (fr)
PL (1) PL3307271T3 (fr)
PT (1) PT3307271T (fr)
RS (1) RS64777B1 (fr)
SI (1) SI3307271T1 (fr)
WO (1) WO2016201227A1 (fr)

Families Citing this family (15)

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PL2448582T3 (pl) 2009-06-29 2017-09-29 Agios Pharmaceuticals, Inc. Pochodne chinolino-8-sulfonamidowe mające działanie przeciwnowotworowe
CN103764147B (zh) 2011-05-03 2018-05-22 安吉奥斯医药品有限公司 用于治疗的丙酮酸激酶活化剂
KR102296703B1 (ko) 2017-03-20 2021-09-01 포르마 세라퓨틱스 인크. 피루베이트 키나제 (pkr) 활성화제로서의 피롤로피롤 조성물
WO2019099651A1 (fr) * 2017-11-16 2019-05-23 Agios Pharmaceuticals, Inc. Procédés d'utilisation d'activateurs de pyruvate kinase deutérés
ES2959764T3 (es) * 2017-11-22 2024-02-28 Agios Pharmaceuticals Inc Formas cristalinas de n-(4-(4-(ciclopropilmetil) piperazina-1-carbonil)fenil)quinolina-8-sulfonamida
CN108169370B (zh) * 2017-12-19 2020-09-04 万舒（北京）医药科技有限公司 测定生物样品中丙酮酸乙酯及其代谢物丙酮酸的方法
US20230055923A1 (en) 2018-09-19 2023-02-23 Forma Therapeutics, Inc. Activating pyruvate kinase r
BR112021005188A2 (pt) 2018-09-19 2021-06-08 Forma Therapeutics, Inc. tratamento de anemia falciforme com um composto de ativação de piruvato cinase r
AU2020280045A1 (en) 2019-05-22 2021-12-23 Agios Pharmaceuticals, Inc. Crystalline salt forms of N-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide
US11878049B1 (en) 2019-06-14 2024-01-23 Agios Pharmaceuticals, Inc. Mitapivat therapy and modulators of cytochrome P450
MX2023003431A (es) 2020-09-25 2023-05-12 Agios Pharmaceuticals Inc Formulacion farmaceutica.
WO2022231627A1 (fr) 2021-04-30 2022-11-03 Agios Pharmaceuticals, Inc. Procédés de titrage de mitapivat pour une utilisation dans le traitement de la thalassémie
WO2023154036A1 (fr) 2022-02-08 2023-08-17 Agios Pharmaceuticals, Inc. Procédés de titrage de mitapivat
TW202308630A (zh) 2021-04-30 2023-03-01 美商阿吉歐斯製藥公司 用於滴定米塔皮瓦的方法
WO2023091414A1 (fr) 2021-11-16 2023-05-25 Agios Pharmaceuticals, Inc. Composés pour le traitement d'anémies associées au mds et d'autres affections

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