PL3307271T3 - Sposoby stosowania aktywatorów kinazy pirogronianowej - Google Patents

Sposoby stosowania aktywatorów kinazy pirogronianowej

Info

Publication number
PL3307271T3
PL3307271T3 PL16808374.9T PL16808374T PL3307271T3 PL 3307271 T3 PL3307271 T3 PL 3307271T3 PL 16808374 T PL16808374 T PL 16808374T PL 3307271 T3 PL3307271 T3 PL 3307271T3
Authority
PL
Poland
Prior art keywords
methods
pyruvate kinase
kinase activators
activators
pyruvate
Prior art date
Application number
PL16808374.9T
Other languages
English (en)
Inventor
Samuel V. Agresta
Yue Chen
Marvin Barry Cohen
Leonard Luan C. Dang
Charles KUNG
Elizabeth A. Merica
Bruce Alan Silver
Hua Yang
Original Assignee
Agios Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agios Pharmaceuticals, Inc. filed Critical Agios Pharmaceuticals, Inc.
Publication of PL3307271T3 publication Critical patent/PL3307271T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
PL16808374.9T 2015-06-11 2016-06-10 Sposoby stosowania aktywatorów kinazy pirogronianowej PL3307271T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562174216P 2015-06-11 2015-06-11
PCT/US2016/036893 WO2016201227A1 (en) 2015-06-11 2016-06-10 Methods of using pyruvate kinase activators

Publications (1)

Publication Number Publication Date
PL3307271T3 true PL3307271T3 (pl) 2024-02-05

Family

ID=57504271

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16808374.9T PL3307271T3 (pl) 2015-06-11 2016-06-10 Sposoby stosowania aktywatorów kinazy pirogronianowej

Country Status (20)

Country Link
US (2) US11234976B2 (pl)
EP (2) EP3307271B1 (pl)
JP (3) JP7320339B2 (pl)
AU (2) AU2016276951B2 (pl)
CA (1) CA2989111C (pl)
DK (1) DK3307271T3 (pl)
ES (1) ES2959690T3 (pl)
FI (1) FI3307271T3 (pl)
HK (1) HK1253727A1 (pl)
HR (1) HRP20231247T1 (pl)
HU (1) HUE063541T2 (pl)
LT (1) LT3307271T (pl)
MA (1) MA44392B1 (pl)
MD (1) MD3307271T2 (pl)
MX (1) MX2017016041A (pl)
PL (1) PL3307271T3 (pl)
PT (1) PT3307271T (pl)
RS (1) RS64777B1 (pl)
SI (1) SI3307271T1 (pl)
WO (1) WO2016201227A1 (pl)

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CN102481300B (zh) 2009-06-29 2015-04-15 安吉奥斯医药品有限公司 治疗性化合物和组合物
PL3406251T3 (pl) 2011-05-03 2024-04-29 Agios Pharmaceuticals, Inc. Aktywatory kinazy pirogronianowej do stosowania w terapii
HUE049979T2 (hu) 2017-03-20 2020-11-30 Forma Therapeutics Inc Pirrolopirrol készítmények piruvát-kináz (PKR) aktivátorokként
WO2019099651A1 (en) * 2017-11-16 2019-05-23 Agios Pharmaceuticals, Inc. Methods of using deuterated pyruvate kinase activators
ES2959764T3 (es) * 2017-11-22 2024-02-28 Agios Pharmaceuticals Inc Formas cristalinas de n-(4-(4-(ciclopropilmetil) piperazina-1-carbonil)fenil)quinolina-8-sulfonamida
CN108169370B (zh) * 2017-12-19 2020-09-04 万舒(北京)医药科技有限公司 测定生物样品中丙酮酸乙酯及其代谢物丙酮酸的方法
BR112021005188A2 (pt) 2018-09-19 2021-06-08 Forma Therapeutics, Inc. tratamento de anemia falciforme com um composto de ativação de piruvato cinase r
CN113226356A (zh) 2018-09-19 2021-08-06 福马治疗股份有限公司 活化丙酮酸激酶r
AU2020280045A1 (en) 2019-05-22 2021-12-23 Agios Pharmaceuticals, Inc. Crystalline salt forms of N-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide
US11878049B1 (en) * 2019-06-14 2024-01-23 Agios Pharmaceuticals, Inc. Mitapivat therapy and modulators of cytochrome P450
KR20230074536A (ko) 2020-09-25 2023-05-30 아지오스 파마슈티컬스 아이엔씨. 약제학적 제형
CA3218401A1 (en) 2021-04-30 2022-11-03 Agios Pharmaceuticals, Inc. Methods for titrating mitapivat
WO2022231627A1 (en) 2021-04-30 2022-11-03 Agios Pharmaceuticals, Inc. Methods for titrating mitapivat for use in treating thalassemia
WO2023154036A1 (en) 2022-02-08 2023-08-17 Agios Pharmaceuticals, Inc. Methods for titrating mitapivat
IL312679A (en) 2021-11-16 2024-07-01 Agios Pharmaceuticals Inc Compounds for the treatment of anemia associated with MDS and other conditions

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