DE69322076D1 - S-triazin-derivate und diese als aktiven wirkstoff enthaltende heilmittel gegen östrogen abhängige krankheiten - Google Patents
S-triazin-derivate und diese als aktiven wirkstoff enthaltende heilmittel gegen östrogen abhängige krankheitenInfo
- Publication number
- DE69322076D1 DE69322076D1 DE69322076T DE69322076T DE69322076D1 DE 69322076 D1 DE69322076 D1 DE 69322076D1 DE 69322076 T DE69322076 T DE 69322076T DE 69322076 T DE69322076 T DE 69322076T DE 69322076 D1 DE69322076 D1 DE 69322076D1
- Authority
- DE
- Germany
- Prior art keywords
- ostrogen
- active ingredients
- triazine derivatives
- dependent diseases
- ingredients against
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7844992 | 1992-02-28 | ||
PCT/JP1993/000240 WO1993017009A1 (en) | 1992-02-28 | 1993-02-26 | s-TRIAZINE DERIVATIVE AND REMEDY FOR ESTROGEN-DEPENDENT DISEASES CONTAINING THE SAME AS ACTIVE INGREDIENT |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69322076D1 true DE69322076D1 (de) | 1998-12-17 |
Family
ID=13662350
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69322076T Expired - Lifetime DE69322076D1 (de) | 1992-02-28 | 1993-02-26 | S-triazin-derivate und diese als aktiven wirkstoff enthaltende heilmittel gegen östrogen abhängige krankheiten |
Country Status (7)
Country | Link |
---|---|
US (1) | US5489591A (de) |
EP (1) | EP0629622B1 (de) |
KR (1) | KR950700282A (de) |
AU (1) | AU665238B2 (de) |
CA (1) | CA2131004A1 (de) |
DE (1) | DE69322076D1 (de) |
WO (1) | WO1993017009A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6432947B1 (en) | 1997-02-19 | 2002-08-13 | Berlex Laboratories, Inc. | N-heterocyclic derivatives as NOS inhibitors |
WO1999036410A1 (en) * | 1998-01-13 | 1999-07-22 | Scriptgen Pharmaceuticals, Inc. | Triazine antiviral compounds |
US6335339B1 (en) | 1998-01-13 | 2002-01-01 | Scriptgen Pharmaceuticals, Inc. | Triazine antiviral compounds |
US6943161B2 (en) * | 1999-12-28 | 2005-09-13 | Pharmacopela Drug Discovery, Inc. | Pyrimidine and triazine kinase inhibitors |
US6525051B2 (en) | 2000-03-27 | 2003-02-25 | Schering Aktiengesellschaft | N-heterocyclic derivatives as NOS inhibitors |
BR0111158A (pt) | 2000-05-12 | 2004-04-06 | Genzyme Corp | Composto e sais fisiológicos do mesmo, método para tratar uma condição mediana por tnf-a em um paciente |
US6716851B2 (en) | 2000-12-12 | 2004-04-06 | Cytovia, Inc. | Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof |
AU2002228922A1 (en) * | 2000-12-12 | 2002-06-24 | Cytovia, Inc. | Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
US6943162B2 (en) | 2001-01-26 | 2005-09-13 | Smithkline Beecham Corporation | Piperazinyltriazines as estrogen receptor modulators |
KR100833371B1 (ko) | 2001-04-27 | 2008-05-28 | 젠야쿠코교가부시키가이샤 | 헤테로시클릭 화합물 및 이를 유효 성분으로 하는 항종양제 |
US6982259B2 (en) * | 2002-04-30 | 2006-01-03 | Schering Aktiengesellschaft | N-heterocyclic derivatives as NOS inhibitors |
US7153853B2 (en) * | 2002-10-25 | 2006-12-26 | Zenyaku Kogyo Kabushiki Kaisha | Heterocyclic compounds and antitumor drugs containing the same as the active ingredient |
WO2006065872A1 (en) * | 2004-12-13 | 2006-06-22 | Neurogen Corporation | Piperazinyl-pyridine analogues |
WO2006095906A1 (ja) * | 2005-03-11 | 2006-09-14 | Zenyaku Kogyo Kabushikikaisha | 複素環式化合物を有効成分とする免疫抑制剤及び抗腫瘍剤 |
US20070244110A1 (en) * | 2006-04-14 | 2007-10-18 | Zenyaku Kogyo Kabushiki Kaisha | Treatment of prostate cancer, melanoma or hepatic cancer |
US20110053907A1 (en) * | 2008-03-27 | 2011-03-03 | Auckland Uniservices Limited | Substituted pyrimidines and triazines and their use in cancer therapy |
US8575338B2 (en) | 2008-04-09 | 2013-11-05 | Mitsubishi Tanabe Pharma Corporation | Pyrimidine, pyridine and triazine derivatives as maxi-K channel openers |
GB2465405A (en) * | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
CN108524505A (zh) | 2009-03-13 | 2018-09-14 | 安吉奥斯医药品有限公司 | 用于细胞增殖相关病症的方法和组合物 |
KR101712035B1 (ko) | 2009-06-29 | 2017-03-03 | 아지오스 파마슈티컬스 아이엔씨. | 치료용 화합물 및 조성물 |
AR077999A1 (es) * | 2009-09-02 | 2011-10-05 | Vifor Int Ag | Antagonistas de pirimidin y triazin-hepcidina |
EP3064595B1 (de) | 2009-10-21 | 2019-02-27 | Agios Pharmaceuticals, Inc. | Verfahren für zellproliferationsbedingte erkrankungen |
HUE032522T2 (en) | 2010-10-27 | 2017-09-28 | The Walter And Eliza Hall Inst Of Medical Res | New anticancer drugs |
FI3406251T3 (fi) | 2011-05-03 | 2024-02-21 | Agios Pharmaceuticals Inc | Pyruvaattikinaasin aktivaattoreita terapeuttista käyttöä varten |
CN102827170A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
MX358940B (es) | 2012-01-06 | 2018-09-10 | Agios Pharmaceuticals Inc Star | Compuestos terapéuticamente activos y sus métodos de uso. |
US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
AU2013331626B2 (en) | 2012-10-15 | 2018-08-02 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
US9579324B2 (en) * | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
US10376510B2 (en) | 2013-07-11 | 2019-08-13 | Agios Pharmaceuticals, Inc. | 2,4- or 4,6-diaminopyrimidine compounds as IDH2 mutants inhibitors for the treatment of cancer |
EP3019490B1 (de) | 2013-07-11 | 2020-06-03 | Agios Pharmaceuticals, Inc. | N,6-bis(aryl oder heteroaryl)-1,3,5-triazin-2,4-diamin-verbindungen als idh2-mutanten-inhibitoren für die behandlung von krebs |
CN105473560B (zh) * | 2013-07-11 | 2020-01-17 | 安吉奥斯医药品有限公司 | 治疗活性化合物及其使用方法 |
WO2015003360A2 (en) * | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
NZ723859A (en) | 2014-03-14 | 2023-01-27 | Servier Lab | Pharmaceutical compositions of therapeutically active compounds and their uses |
MA44392B1 (fr) | 2015-06-11 | 2023-10-31 | Agios Pharmaceuticals Inc | Procédés d'utilisation d'activateurs de la pyruvate kinase |
EP3362066B1 (de) | 2015-10-15 | 2021-10-06 | Les Laboratoires Servier SAS | Kombinationstherapie zur behandlung von malignitäten |
CA3002067C (en) | 2015-10-15 | 2023-11-28 | Agios Pharmaceuticals, Inc. | Combination therapy for treating malignancies |
JP7039370B2 (ja) * | 2018-04-06 | 2022-03-22 | 四国化成工業株式会社 | イミダゾリルトリアジン化合物及びその利用 |
US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3308122A (en) * | 1965-05-10 | 1967-03-07 | Dow Chemical Co | Trimidazolyl triazine compounds |
JPS4917677B1 (de) * | 1970-12-30 | 1974-05-02 | ||
JPS5655302A (en) * | 1979-10-15 | 1981-05-15 | Hokko Chem Ind Co Ltd | Fungicide for agriculture and horticulture |
DE3611427A1 (de) * | 1986-04-05 | 1987-10-08 | Hoechst Ag | Bis-tertiaerbutylamino-substituierte 1,3,5-triazinderivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
-
1993
- 1993-02-26 CA CA002131004A patent/CA2131004A1/en not_active Abandoned
- 1993-02-26 AU AU35751/93A patent/AU665238B2/en not_active Ceased
- 1993-02-26 US US08/290,870 patent/US5489591A/en not_active Expired - Fee Related
- 1993-02-26 EP EP93904356A patent/EP0629622B1/de not_active Expired - Lifetime
- 1993-02-26 DE DE69322076T patent/DE69322076D1/de not_active Expired - Lifetime
- 1993-02-26 WO PCT/JP1993/000240 patent/WO1993017009A1/ja active IP Right Grant
-
1994
- 1994-08-27 KR KR1019940703005A patent/KR950700282A/ko active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP0629622A1 (de) | 1994-12-21 |
WO1993017009A1 (en) | 1993-09-02 |
CA2131004A1 (en) | 1993-09-02 |
KR950700282A (ko) | 1995-01-16 |
EP0629622B1 (de) | 1998-11-11 |
EP0629622A4 (de) | 1995-01-18 |
AU3575193A (en) | 1993-09-13 |
US5489591A (en) | 1996-02-06 |
AU665238B2 (en) | 1995-12-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |