AR077999A1 - Antagonistas de pirimidin y triazin-hepcidina - Google Patents
Antagonistas de pirimidin y triazin-hepcidinaInfo
- Publication number
- AR077999A1 AR077999A1 ARP100103174A ARP100103174A AR077999A1 AR 077999 A1 AR077999 A1 AR 077999A1 AR P100103174 A ARP100103174 A AR P100103174A AR P100103174 A ARP100103174 A AR P100103174A AR 077999 A1 AR077999 A1 AR 077999A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- group
- hydrogen
- heterocyclyl
- aryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
- C07D251/66—Derivatives of melamine in which a hetero atom is directly attached to a nitrogen atom of melamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Composiciones farmacéuticas que los contienen y su uso como medicamento, particularmente para el tratamiento de desordenes del metabolismo del hierro, particularmente, enfermedades por deficiencia de hierro y anemias, en particular anemia asociada con enfermedad inflamatoria cronica (ACD), anemia de enfermedad cronica y anemia por inflamacion, y los síntomas asociados. Reivindicacion 1: Compuestos de la formula general (1), en que X está elegido del grupo que comprende N o C-R1, estando elegido R1 del grupo que comprende: hidrogeno, hidroxilo, halogeno, carboxilo, radical ácido sulfonico (-SO3H), aminocarbonilo opcionalmente sustituido, aminosulfonilo opcionalmente sustituido, amino opcionalmente sustituido, alquilo opcionalmente sustituido, acilo opcionalmente sustituido, alcoxicarbonilo opcionalmente sustituido, aciloxi opcionalmente sustituido, alcoxi opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, arilo opcionalmente sustituido, heterociclilo opcionalmente sustituido; R2 y R3 son iguales o distintos entre sí y cada uno de ellos está elegido del grupo que comprende: hidrogeno, hidroxilo, halogeno, carboxilo, radical ácido sulfonico (-SO3H), aminocarbonilo opcionalmente sustituido, aminosulfonilo opcionalmente sustituido, amino opcionalmente sustituido, alquilo opcionalmente sustituido, acilo opcionalmente sustituido, alcoxicarbonilo opcionalmente sustituido, aciloxi opcionalmente sustituido, alcoxi opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, arilo opcionalmente sustituido, heterociclilo opcionalmente sustituido; Y está elegido del grupo que comprende: hidrogeno, hidroxilo, halogeno, ariloxi opcionalmente sustituido, y el grupo de la formula, -N(R4)(R5) en la cual: R4 y R5 pueden ser iguales o distintos entre sí, y cada uno de ellos está elegido del grupo que comprende: hidrogeno, amino opcionalmente sustituido, aminocarbonilo opcionalmente sustituido, alquilo, arilo o heterociclil-sulfonilo opcionalmente sustituidos, alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, acilo opcionalmente sustituido, arilo opcionalmente sustituido, heterociclilo opcionalmente sustituido o R4 y R5 conjuntamente con el átomo de nitrogeno al cual están ligados, forman un ciclo saturado o insaturado, opcionalmente sustituido de 3 a 8 miembros, que opcionalmente puede contener otros heteroátomos; o sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09169286 | 2009-09-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR077999A1 true AR077999A1 (es) | 2011-10-05 |
Family
ID=41490366
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100103174A AR077999A1 (es) | 2009-09-02 | 2010-08-30 | Antagonistas de pirimidin y triazin-hepcidina |
Country Status (21)
Country | Link |
---|---|
US (1) | US20120202806A1 (es) |
EP (1) | EP2473486B2 (es) |
JP (1) | JP2013503833A (es) |
KR (1) | KR20120061055A (es) |
CN (1) | CN102482232A (es) |
AR (1) | AR077999A1 (es) |
AU (1) | AU2010291318A1 (es) |
BR (1) | BR112012008109A2 (es) |
CA (1) | CA2769553A1 (es) |
CL (1) | CL2012000591A1 (es) |
CR (1) | CR20120097A (es) |
DO (1) | DOP2012000057A (es) |
EA (1) | EA201200402A1 (es) |
ES (1) | ES2554855T3 (es) |
IL (1) | IL218253A0 (es) |
MA (1) | MA33538B1 (es) |
MX (1) | MX2012002626A (es) |
SG (1) | SG178984A1 (es) |
TN (1) | TN2012000045A1 (es) |
TW (1) | TW201113272A (es) |
WO (1) | WO2011026835A1 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
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AR077999A1 (es) | 2009-09-02 | 2011-10-05 | Vifor Int Ag | Antagonistas de pirimidin y triazin-hepcidina |
DE102010002558A1 (de) * | 2009-11-20 | 2011-06-01 | Symrise Ag | Verwendung physiologischer Kühlwirkstoffe und Mittel enthaltend solche Wirkstoffe |
EP2595965B1 (en) | 2010-07-20 | 2016-06-22 | Vestaron Corporation | Insecticidal triazines and pyrimidines |
CZ305457B6 (cs) | 2011-02-28 | 2015-09-30 | Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. | Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití |
CA2849995A1 (en) | 2011-09-27 | 2013-04-04 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
JP2014237590A (ja) * | 2011-09-30 | 2014-12-18 | アステラス製薬株式会社 | 2−(ピリジン−2−イル)ピリミジン−4−アミン化合物又はその塩 |
UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
DK3459942T3 (da) | 2012-04-24 | 2021-03-08 | Vertex Pharma | DNA-PK-hæmmere |
US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
WO2014105952A2 (en) * | 2012-12-28 | 2014-07-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inhibitors of the usp1/uaf1 deubiquitinase complex and uses thereof |
JP6120311B2 (ja) * | 2013-02-12 | 2017-04-26 | 学校法人銀杏学園 | ポリフェノール化合物 |
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UY35735A (es) | 2013-09-16 | 2015-04-30 | Bayer Pharma AG | Trifluorometilpirimidinonas disustituidas y su uso |
LT3424920T (lt) | 2013-10-17 | 2020-08-10 | Vertex Pharmaceuticals Incorporated | (s)-n-metil-8-(1-((2`-metil-[4,5`-bipirimidin]-6-il)amino)propan-2-il)chinolin-4-karboksamido ir jo deuterintų darinių, kaip dnr-pk inhibitorių, bendri kristalai |
US10981899B2 (en) | 2016-04-28 | 2021-04-20 | Cornell University | Inhibitors of soluble adenylyl cyclase |
US10774064B2 (en) | 2016-06-02 | 2020-09-15 | Cadent Therapeutics, Inc. | Potassium channel modulators |
MX2019003317A (es) | 2016-09-27 | 2019-08-05 | Vertex Pharma | Metodo para tratar cancer usando una combinacion de agentes que dañan adn e inhibidores de proteina cinasa dependiente de adn (adn-pk). |
ES2906078T3 (es) | 2017-01-23 | 2022-04-13 | Cadent Therapeutics Inc | Moduladores del canal de potasio |
WO2018187652A1 (en) | 2017-04-06 | 2018-10-11 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives as histamine h4 modulators |
EP3675809B1 (de) | 2017-08-31 | 2023-09-27 | Basf Se | Verwendung physiologischer kühlwirkstoffe und mittel enthaltend solche wirkstoffe |
AU2021263818A1 (en) * | 2020-04-28 | 2022-11-03 | Global Blood Therapeutics, Inc. | Cycloalkyl pyrimidines as ferroportin inhibitors |
EP4142732A1 (en) * | 2020-04-28 | 2023-03-08 | Global Blood Therapeutics, Inc. | Methods of use for pyrimidines as ferroportin inhibitors |
US20230159553A1 (en) * | 2020-04-28 | 2023-05-25 | Global Blood Therapeutics, Inc | Thieno pyrimidines as ferroportin inhibitors |
CN112028838B (zh) * | 2020-08-04 | 2022-07-01 | 精华制药集团南通有限公司 | 一种2-乙氧基-5-氟尿嘧啶杂质的制备方法 |
CN113683596B (zh) * | 2021-08-17 | 2023-02-10 | 上海应用技术大学 | 一种嘧啶类端锚聚合酶2抑制剂及其制备方法和应用 |
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WO2009044284A1 (en) | 2007-10-02 | 2009-04-09 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Antibodies specific for human hepcidin |
TWI409276B (zh) | 2007-11-02 | 2013-09-21 | Lilly Co Eli | 抗-海帕西啶(hepcidin)抗體及其用途 |
US20110124649A1 (en) * | 2007-11-09 | 2011-05-26 | The Johns Hopkins University | Inhibitors of human methionine aminopeptidase 1 and methods of treating disorders |
JP5587206B2 (ja) * | 2007-12-19 | 2014-09-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | JAK2阻害剤として有用なピラゾロ[1,5−a]ピリミジン |
WO2009093981A1 (en) * | 2008-01-23 | 2009-07-30 | S Bio Pte Ltd | Triazine compounds as kinase inhibitors |
CN101938988B (zh) | 2008-02-08 | 2013-06-19 | 株式会社资生堂 | 美白剂和皮肤外用剂 |
ES2524883T3 (es) * | 2008-03-18 | 2014-12-15 | Merck Sharp & Dohme Corp. | 4-Hidroxipirimidina-5-carboxamidas sustituidas |
AR077999A1 (es) | 2009-09-02 | 2011-10-05 | Vifor Int Ag | Antagonistas de pirimidin y triazin-hepcidina |
-
2010
- 2010-08-30 AR ARP100103174A patent/AR077999A1/es not_active Application Discontinuation
- 2010-08-31 US US13/391,712 patent/US20120202806A1/en not_active Abandoned
- 2010-08-31 WO PCT/EP2010/062708 patent/WO2011026835A1/de active Application Filing
- 2010-08-31 CN CN2010800389946A patent/CN102482232A/zh active Pending
- 2010-08-31 SG SG2012015319A patent/SG178984A1/en unknown
- 2010-08-31 MX MX2012002626A patent/MX2012002626A/es not_active Application Discontinuation
- 2010-08-31 AU AU2010291318A patent/AU2010291318A1/en not_active Abandoned
- 2010-08-31 KR KR1020127008573A patent/KR20120061055A/ko not_active Application Discontinuation
- 2010-08-31 ES ES10747859.6T patent/ES2554855T3/es active Active
- 2010-08-31 CA CA2769553A patent/CA2769553A1/en not_active Abandoned
- 2010-08-31 EA EA201200402A patent/EA201200402A1/ru unknown
- 2010-08-31 JP JP2012527300A patent/JP2013503833A/ja active Pending
- 2010-08-31 BR BR112012008109A patent/BR112012008109A2/pt not_active IP Right Cessation
- 2010-08-31 EP EP10747859.6A patent/EP2473486B2/de active Active
- 2010-09-01 TW TW099129457A patent/TW201113272A/zh unknown
-
2012
- 2012-01-27 TN TNP2012000045A patent/TN2012000045A1/en unknown
- 2012-02-22 IL IL218253A patent/IL218253A0/en unknown
- 2012-02-27 MA MA34652A patent/MA33538B1/fr unknown
- 2012-02-27 CR CR20120097A patent/CR20120097A/es unknown
- 2012-03-01 DO DO2012000057A patent/DOP2012000057A/es unknown
- 2012-03-02 CL CL2012000591A patent/CL2012000591A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN102482232A (zh) | 2012-05-30 |
WO2011026835A1 (de) | 2011-03-10 |
ES2554855T3 (es) | 2015-12-23 |
MA33538B1 (fr) | 2012-08-01 |
TN2012000045A1 (en) | 2013-09-19 |
BR112012008109A2 (pt) | 2019-09-24 |
MX2012002626A (es) | 2012-04-20 |
EA201200402A1 (ru) | 2012-08-30 |
EP2473486B1 (de) | 2015-10-28 |
US20120202806A1 (en) | 2012-08-09 |
CA2769553A1 (en) | 2011-03-10 |
CL2012000591A1 (es) | 2012-08-03 |
AU2010291318A1 (en) | 2012-03-01 |
JP2013503833A (ja) | 2013-02-04 |
EP2473486B2 (de) | 2021-09-22 |
SG178984A1 (en) | 2012-04-27 |
EP2473486A1 (de) | 2012-07-11 |
TW201113272A (en) | 2011-04-16 |
DOP2012000057A (es) | 2012-08-31 |
IL218253A0 (en) | 2012-04-30 |
KR20120061055A (ko) | 2012-06-12 |
CR20120097A (es) | 2012-09-03 |
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