DE69815833D1 - Amoxicillin und clavulanat enthaltende arzneizubereitungen - Google Patents

Amoxicillin und clavulanat enthaltende arzneizubereitungen

Info

Publication number
DE69815833D1
DE69815833D1 DE69815833T DE69815833T DE69815833D1 DE 69815833 D1 DE69815833 D1 DE 69815833D1 DE 69815833 T DE69815833 T DE 69815833T DE 69815833 T DE69815833 T DE 69815833T DE 69815833 D1 DE69815833 D1 DE 69815833D1
Authority
DE
Germany
Prior art keywords
clavulanate
preparations containing
medical preparations
containing amoxicillin
amoxicillin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69815833T
Other languages
English (en)
Other versions
DE69815833T2 (de
Inventor
Jacky Andre Gustave Mention
Bordallo Jose Luis Sanroma
Kevin Storm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham SA
Laboratoire GlaxoSmithKline SAS
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham SA
Laboratoire GlaxoSmithKline SAS
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9703101.7A external-priority patent/GB9703101D0/en
Priority claimed from GBGB9703100.9A external-priority patent/GB9703100D0/en
Priority claimed from GBGB9703099.3A external-priority patent/GB9703099D0/en
Application filed by SmithKline Beecham SA, Laboratoire GlaxoSmithKline SAS, SmithKline Beecham Corp filed Critical SmithKline Beecham SA
Application granted granted Critical
Publication of DE69815833D1 publication Critical patent/DE69815833D1/de
Publication of DE69815833T2 publication Critical patent/DE69815833T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
DE69815833T 1997-02-14 1998-02-10 Amoxicillin und clavulanat enthaltende arzneizubereitungen Expired - Lifetime DE69815833T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9703101 1997-02-14
GB9703099 1997-02-14
GBGB9703101.7A GB9703101D0 (en) 1997-02-14 1997-02-14 Formulations
GBGB9703100.9A GB9703100D0 (en) 1997-02-14 1997-02-14 Formulations
GBGB9703099.3A GB9703099D0 (en) 1997-02-14 1997-02-14 Formulations
GB9703100 1997-02-14
PCT/EP1998/000811 WO1998035672A1 (en) 1997-02-14 1998-02-10 Pharmaceutical formulations comprising amoxocyllin and clavulanate

Publications (2)

Publication Number Publication Date
DE69815833D1 true DE69815833D1 (de) 2003-07-31
DE69815833T2 DE69815833T2 (de) 2004-05-19

Family

ID=27268719

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69815833T Expired - Lifetime DE69815833T2 (de) 1997-02-14 1998-02-10 Amoxicillin und clavulanat enthaltende arzneizubereitungen

Country Status (25)

Country Link
EP (2) EP0975342B1 (de)
JP (1) JP2001512451A (de)
KR (1) KR100499812B1 (de)
CN (1) CN1194687C (de)
AP (1) AP1253A (de)
AT (1) ATE243516T1 (de)
AU (1) AU728526B2 (de)
BG (1) BG103664A (de)
BR (1) BR9807383A (de)
CA (1) CA2280857A1 (de)
DE (1) DE69815833T2 (de)
DZ (1) DZ2420A1 (de)
EA (1) EA002595B1 (de)
ES (1) ES2201468T3 (de)
HK (1) HK1043041A1 (de)
ID (1) ID23673A (de)
IL (1) IL131201A (de)
MA (1) MA24473A1 (de)
NO (1) NO993887D0 (de)
NZ (1) NZ337043A (de)
OA (1) OA11087A (de)
PL (1) PL334976A1 (de)
SK (1) SK110299A3 (de)
TR (1) TR199901961T2 (de)
WO (1) WO1998035672A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9416600D0 (en) * 1994-08-17 1994-10-12 Smithkline Beecham Plc Pharmaceutical formulation
AR004510A1 (es) 1995-09-07 1998-12-16 Smithkline Beecham Plc Composiciones que comprenden amoxicilina y clavulanato, procedimientos para su preparacion y el uso de las composiciones para la fabricacion de unmedicamento
GB9815532D0 (en) * 1998-07-17 1998-09-16 Lek Pharmaceutical & Cvhemical Pharmaceutical suspension formulation
WO2000050036A1 (en) * 1999-02-26 2000-08-31 Biovail International Ltd. Storage stable amoxycillin and clavulanate suspension composition
US6294199B1 (en) * 1999-04-13 2001-09-25 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising administering amoxycillin
NL1014915C2 (nl) * 1999-04-13 2001-02-12 Beecham Pharm Pte Ltd Nieuwe behandelingsmethode.
US6878386B1 (en) 1999-04-13 2005-04-12 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate
FR2797588B1 (fr) * 1999-08-20 2003-08-01 Smithkline Beecham Lab Formulation pharmaceutique a base d'amoxycilline et de clavulanate
PT1078627E (pt) * 1999-08-20 2006-10-31 Glaxosmithkline Lab Sas Formulacao farmaceutica compreendendo amoxicilina e clavulanato
US6541025B1 (en) * 1999-12-30 2003-04-01 Shear/Kershman Laboratories, Inc. Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals
US6375982B1 (en) * 2000-07-05 2002-04-23 Capricorn Pharma, Inc. Rapid-melt semi-solid compositions, methods of making same and method of using same
WO2002030392A2 (en) 2000-10-12 2002-04-18 Beecham Pharmaceuticals (Pte) Limited Formulation containing amoxicillin
US6756057B2 (en) 2000-10-12 2004-06-29 Beecham Pharmaceuticals (Pte) Limited Amoxicillin and potassium clavulanate dosage form
AT413983B (de) * 2001-04-12 2006-08-15 Sandoz Ag K-clavulanat in der form eines granulates
AT412344B (de) * 2001-04-12 2005-01-25 Sandoz Ag Hydrophobisierte teilchen von k-clavulanat
EP1474104A2 (de) * 2002-02-01 2004-11-10 Sandoz Ag Entmischungsstabiles granulat
KR20050062514A (ko) * 2002-07-16 2005-06-23 랜박시 래보러터리스 리미티드 경구 투여용 분산성 정제
JP2006527726A (ja) * 2003-06-16 2006-12-07 グラクソ　グループ　リミテッド アモキシシリンおよびクラブラン酸塩を含む医薬製剤
KR100676617B1 (ko) * 2004-06-18 2007-01-30 주식회사유한양행 아목시실린 및/또는 클라불란산 또는 이의 염을 함유하는경구용 현탁정제 조성물
SI21912A (sl) * 2004-12-24 2006-06-30 Lek Farmacevtska Druzba D.D. Stabilne farmacevtske oblike, ki vsebujejo amoksicilin in klavulansko kislino
DE102006007830A1 (de) * 2006-02-17 2007-08-30 Grünenthal GmbH Lagerstabile orale Darreichungsform von Amoxicillin und Clavulansäure
CN100464750C (zh) * 2006-02-23 2009-03-04 珠海联邦制药股份有限公司 一种制备含阿莫西林钠和克拉维酸钾的药物混合物的方法
FI20080352A0 (fi) * 2008-05-09 2008-05-09 Atacama Labs Oy Prosessi korkean lääkepitoisuuden tabletin valmistamiseksi
FI20080351A0 (fi) * 2008-05-09 2008-05-09 Atacama Labs Oy Prosessi matalan lääkepitoisuuden tabletin valmistamiseksi
US8951562B2 (en) 2006-11-10 2015-02-10 Atacama Labs Oy Method and apparatus or dry granulation
FI20070521L (fi) 2006-11-10 2008-05-11 Atacama Labs Oy Rakeita, tabletteja ja rakeistusmenetelmä
EP2291233B1 (de) 2008-05-09 2019-09-04 Atacama Labs Oy Verfahren für trockene granulation
CN102861015B (zh) * 2011-07-05 2015-07-08 北京乐维生物技术有限公司 一种稳定的阿莫西林克拉维酸钾缓释制剂及其制备工艺
WO2014065769A1 (en) * 2012-10-22 2014-05-01 Bilgiç Mahmut Formulations for oral suspensions comprising antibiotics
HUE048496T2 (hu) * 2013-09-20 2020-07-28 Centrient Pharmaceuticals Netherlands B V Kroszpovidont tartalmazó tabletta
US9254261B2 (en) * 2014-03-03 2016-02-09 Sandoz Ag Stable quick dissolving dosage form comprising amoxicillin and clavulanic acid
EP3994154A1 (de) 2019-07-05 2022-05-11 GlaxoSmithKline Intellectual Property (No.2) Limited Streptomyces clavuligerus
CN113274357B (zh) * 2021-05-28 2022-12-27 广州白云山医药集团股份有限公司白云山制药总厂 一种阿莫西林药物及其制备方法
CN114869884A (zh) * 2021-07-30 2022-08-09 江苏恒丰强生物技术有限公司 一种用于猪呼吸道疾病的复方阿莫西林粉及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
US4140764A (en) * 1974-12-18 1979-02-20 Beecham Group Limited β-Lactamase inhibitors and process for their preparation
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration
NZ198241A (en) * 1980-09-27 1983-12-16 Beecham Group Ltd Tablet containing amoxycillin and potassium clavulanate
GB9109862D0 (en) * 1991-05-08 1991-07-03 Beecham Lab Sa Pharmaceutical formulations
DE69425131T2 (de) * 1993-01-22 2001-03-15 Smithkline Beecham Plc Verwendung von clavulansäure und einem antibiotikum zur behandlung von infektionen
IL109770A0 (en) * 1993-05-29 1994-11-28 Smithkline Beecham Corp Thermal infusion process for preparing controlled release solid dosage forms of medicaments for oral administration and controlled release solid dosage forms of medicaments prepared thereby
GB9402203D0 (en) * 1994-02-04 1994-03-30 Smithkline Beecham Plc Pharmaceutical formulation
GB9405856D0 (en) * 1994-03-24 1994-05-11 Smithkline Beecham Plc Pharmaceutical formulation
GB9407386D0 (en) * 1994-04-14 1994-06-08 Smithkline Beecham Plc Pharmaceutical formulation
GB9408117D0 (en) * 1994-04-23 1994-06-15 Smithkline Beecham Corp Pharmaceutical formulations
DZ1926A1 (fr) * 1994-09-03 2002-02-17 Smithkline Beckman P L C Formulations pharmaceutiques.

Also Published As

Publication number Publication date
ATE243516T1 (de) 2003-07-15
NZ337043A (en) 2001-02-23
EA002595B1 (ru) 2002-06-27
EP0975342B1 (de) 2003-06-25
DE69815833T2 (de) 2004-05-19
IL131201A (en) 2005-06-19
AP9901623A0 (en) 1999-09-30
EP0975342A1 (de) 2000-02-02
MA24473A1 (fr) 1998-10-01
AP1253A (en) 2004-03-17
AU728526B2 (en) 2001-01-11
BR9807383A (pt) 2000-03-14
DZ2420A1 (fr) 2003-01-04
JP2001512451A (ja) 2001-08-21
CA2280857A1 (en) 1998-08-20
TR199901961T2 (xx) 1999-11-22
HK1043041A1 (zh) 2002-09-06
KR20000071076A (ko) 2000-11-25
SK110299A3 (en) 2000-08-14
CN1194687C (zh) 2005-03-30
BG103664A (en) 2000-03-31
CN1251990A (zh) 2000-05-03
AU6719698A (en) 1998-09-08
EA199900647A1 (ru) 2000-06-26
ID23673A (id) 2000-05-11
PL334976A1 (en) 2000-03-27
WO1998035672A1 (en) 1998-08-20
OA11087A (en) 2003-03-13
KR100499812B1 (ko) 2005-07-08
IL131201A0 (en) 2001-01-28
EP1142574A1 (de) 2001-10-10
ES2201468T3 (es) 2004-03-16
NO993887L (no) 1999-08-12
NO993887D0 (no) 1999-08-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition