DE69705324D1 - N-hydroxyharnstoffderivate und sie enthaltende medizinische zubereitungen - Google Patents

N-hydroxyharnstoffderivate und sie enthaltende medizinische zubereitungen

Info

Publication number
DE69705324D1
DE69705324D1 DE69705324T DE69705324T DE69705324D1 DE 69705324 D1 DE69705324 D1 DE 69705324D1 DE 69705324 T DE69705324 T DE 69705324T DE 69705324 T DE69705324 T DE 69705324T DE 69705324 D1 DE69705324 D1 DE 69705324D1
Authority
DE
Germany
Prior art keywords
hydroxy
preparations containing
medical preparations
urine derivatives
urine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69705324T
Other languages
English (en)
Other versions
DE69705324T2 (de
Inventor
M Takano
Toshiya Komatsu
Y Kawahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nikken Chemicals Co Ltd
Original Assignee
Nikken Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP35401797A external-priority patent/JP3558153B2/ja
Priority claimed from JP35401897A external-priority patent/JP3558154B2/ja
Priority claimed from JP35401697A external-priority patent/JP3558152B2/ja
Application filed by Nikken Chemicals Co Ltd filed Critical Nikken Chemicals Co Ltd
Publication of DE69705324D1 publication Critical patent/DE69705324D1/de
Application granted granted Critical
Publication of DE69705324T2 publication Critical patent/DE69705324T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
DE69705324T 1996-12-26 1997-12-25 N-hydroxyharnstoffderivate und sie enthaltende medizinische zubereitungen Expired - Fee Related DE69705324T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP35636096 1996-12-26
JP35635996 1996-12-26
JP35636196 1996-12-26
JP35401797A JP3558153B2 (ja) 1996-12-26 1997-12-09 Ｎ−ヒドロキシ尿素誘導体
JP35401897A JP3558154B2 (ja) 1996-12-26 1997-12-09 Ｎ−ヒドロキシ尿素誘導体
JP35401697A JP3558152B2 (ja) 1996-12-26 1997-12-09 Ｎ−ヒドロキシ尿素誘導体
PCT/JP1997/004856 WO1998029408A1 (fr) 1996-12-26 1997-12-25 Derives de n-hydroxyuree et compositions medicinales a base de ces derives

Publications (2)

Publication Number Publication Date
DE69705324D1 true DE69705324D1 (de) 2001-07-26
DE69705324T2 DE69705324T2 (de) 2001-10-11

Family

ID=27554683

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69705324T Expired - Fee Related DE69705324T2 (de) 1996-12-26 1997-12-25 N-hydroxyharnstoffderivate und sie enthaltende medizinische zubereitungen

Country Status (5)

Country Link
US (1) US6184238B1 (de)
EP (1) EP0949259B1 (de)
CA (1) CA2276042C (de)
DE (1) DE69705324T2 (de)
WO (1) WO1998029408A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6093820A (en) 1997-10-02 2000-07-25 Taro Pharmaceutical Industries Ltd. Method and reagents for N-alkylating ureides
US6265403B1 (en) 1999-01-20 2001-07-24 Merck & Co., Inc. Angiogenesis inhibitors
US6939873B2 (en) * 2000-07-26 2005-09-06 Taro Pharmaceuticals Industries Limited Non-sedating barbituric acid derivatives
US6756379B2 (en) 2001-07-26 2004-06-29 Taro Pharmaceutical Industries Ltd. Non-sedating barbiturate compounds as neuroprotective agents
US7683071B2 (en) * 2000-07-26 2010-03-23 Taro Pharmaceuticals Industries Ltd. Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid
JP4615826B2 (ja) 2001-01-29 2011-01-19 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 置換インドールおよびインテグリンアンタゴニストとしてのそれらの使用
US6872730B2 (en) * 2001-04-27 2005-03-29 3-Dimensional Pharmaceuticals, Inc. Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
EP2335700A1 (de) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C Virus Polymerase Inhibitoren mit heterobicylischer Struktur
CA2505335C (en) 2002-12-11 2013-09-10 Daniel Aaron Moros Method of treating movement disorders using barbituric acid derivatives
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
NZ549079A (en) * 2004-02-20 2010-08-27 Boehringer Ingelheim Int Viral polymerase inhibitors
EP1781624A4 (de) * 2004-07-02 2010-06-23 Taro Pharma Ind Verfahren zur herstellung von 1-methoxymethyl-5,5-diphenylbarbitursäure
JP5015154B2 (ja) * 2005-08-12 2012-08-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルスポリメラーゼインヒビター
WO2008066704A2 (en) * 2006-11-14 2008-06-05 Taro Pharmaceuticals North America, Inc. Method of improving bioavailability for non-sedating barbiturates
AR072297A1 (es) 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
CN105130855B (zh) * 2009-12-07 2018-05-25 约翰斯霍普金斯大学 二酰基化的羟基胺衍生物及其用途
CA2819373A1 (en) * 2010-12-09 2012-06-14 Amgen Inc. Bicyclic compounds as pim inhibitors
JP2014510105A (ja) 2011-03-22 2014-04-24 アムジエン・インコーポレーテツド Ｐｉｍ阻害剤としてのアゾール化合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468894A (en) 1966-11-29 1969-09-23 Geigy Chem Corp Certain 2-pyridyl-substituted indole derivatives
US4511573A (en) 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
EP0412930A1 (de) 1989-08-08 1991-02-13 Alusuisse-Lonza Services Ag Verfahren zur Herstellung eines keramischen Schaumkörpers
ATE144247T1 (de) 1990-07-25 1996-11-15 Abbott Lab Acetylenderivate mit lipoxygenase inhibitorischer wirkung
US5095031A (en) 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
US5329010A (en) 1991-03-11 1994-07-12 Eisai Co., Ltd. Quinone derivatives
US5132319A (en) * 1991-03-28 1992-07-21 Merck Frosst Canada, Inc. 1-(hydroxylaminoalkyl) indole derivatives as inhibitors of leukotriene biosynthesis
JP2848998B2 (ja) 1991-04-04 1999-01-20 エーザイ株式会社 ベンゾチアゾール誘導体
GB9319100D0 (en) 1993-09-15 1993-11-03 Pfizer Ltd 3-(3-pyridinyl)h-indoles
WO1995012589A1 (en) 1993-11-05 1995-05-11 Abbott Laboratories Process for the preparation of n-4-[(substituted phenyl)alkylthienyl]-, and n-4-[(substituted phenyl)alkylfuryl]but-3-yn-2-yl]-n-hydroxyurea compounds
CA2210905A1 (en) 1995-02-02 1996-08-08 Nikken Chemicals Co., Ltd. N-hydroxyurea derivatives
US5714633A (en) 1995-09-12 1998-02-03 Abbott Laboratories Process for the preparation of arylalkynyl-N-hydroxyurea derivatives having lipoxygenase inhibitory activity

Also Published As

Publication number Publication date
WO1998029408A1 (fr) 1998-07-09
EP0949259A4 (de) 2000-02-23
US6184238B1 (en) 2001-02-06
EP0949259A1 (de) 1999-10-13
CA2276042A1 (en) 1998-07-09
CA2276042C (en) 2002-10-08
EP0949259B1 (de) 2001-06-20
DE69705324T2 (de) 2001-10-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee