DE69424853T2 - Morphinan-derivate und ihre medizinische verwendung - Google Patents

Morphinan-derivate und ihre medizinische verwendung

Info

Publication number
DE69424853T2
DE69424853T2 DE69424853T DE69424853T DE69424853T2 DE 69424853 T2 DE69424853 T2 DE 69424853T2 DE 69424853 T DE69424853 T DE 69424853T DE 69424853 T DE69424853 T DE 69424853T DE 69424853 T2 DE69424853 T2 DE 69424853T2
Authority
DE
Germany
Prior art keywords
medical use
morphinan derivatives
morphinan
derivatives
medical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69424853T
Other languages
English (en)
Other versions
DE69424853D1 (de
Inventor
Hiroshi Nagase
Jun Hayakawa
Huniaki Kawamura
Koji Kawai
Takashi Endoh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Publication of DE69424853D1 publication Critical patent/DE69424853D1/de
Application granted granted Critical
Publication of DE69424853T2 publication Critical patent/DE69424853T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
DE69424853T 1993-07-23 1994-07-20 Morphinan-derivate und ihre medizinische verwendung Expired - Fee Related DE69424853T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20212793 1993-07-23
PCT/JP1994/001197 WO1995003308A1 (en) 1993-07-23 1994-07-20 Morphinan derivative and medicinal use

Publications (2)

Publication Number Publication Date
DE69424853D1 DE69424853D1 (de) 2000-07-13
DE69424853T2 true DE69424853T2 (de) 2000-10-05

Family

ID=16452416

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69424853T Expired - Fee Related DE69424853T2 (de) 1993-07-23 1994-07-20 Morphinan-derivate und ihre medizinische verwendung

Country Status (9)

Country Link
US (1) US6177438B1 (de)
EP (1) EP0663401B1 (de)
JP (1) JP3843456B2 (de)
AU (1) AU686203B2 (de)
CA (1) CA2143864C (de)
DE (1) DE69424853T2 (de)
ES (1) ES2146654T3 (de)
NZ (1) NZ268969A (de)
WO (1) WO1995003308A1 (de)

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PT2565195E (pt) 2007-03-29 2015-07-28 Wyeth Llc Antagonistas e receptor opióide periférico e respectivas utilizações
PE20130480A1 (es) 2007-03-29 2013-05-08 Progenics Pharm Inc Compuestos heterociclicos como antagonistas del receptor opioide periferico
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CA2764915C (en) * 2009-06-11 2017-07-11 Mallinckrodt Llc Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer
CA2768236C (en) * 2009-07-16 2018-05-22 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
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JP6013345B2 (ja) * 2010-10-19 2016-10-25 メモリアル スローン−ケタリング キャンサー センター 痛み治療用の４，５ａ−エポキシモルフィナンの６−アミド誘導体
JP2014073964A (ja) * 2011-01-28 2014-04-24 Kitasato Institute モルヒナン誘導体
CN103717601A (zh) * 2011-06-09 2014-04-09 马林克罗特有限公司 通过催化氢转移对6-酮基吗啡喃的还原胺化
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WO2014021273A1 (ja) * 2012-07-30 2014-02-06 学校法人北里研究所 モルヒナン誘導体
TWI449704B (zh) * 2013-04-26 2014-08-21 Everlight Chem Ind Corp 嗎啡喃衍生物之結晶、其製造方法、及使用其之醫藥組成物
US9656962B2 (en) * 2013-12-26 2017-05-23 Purdue Pharma L.P. Ring-contracted morphinans and the use thereof
JPWO2016167318A1 (ja) * 2015-04-16 2018-02-08 学校法人北里研究所 記憶改善剤及びその使用
US11046692B2 (en) 2015-04-30 2021-06-29 Memorial Sloan-Kettering Cancer Center Mitragynine analogs and uses thereof
CA3001658A1 (en) * 2015-10-29 2017-05-04 University Of Tsukuba Morphinan derivative and medical usage thereof
CN106866688B (zh) * 2015-12-10 2019-05-03 山东诚创医药技术开发有限公司 一种纳呋拉啡的精制方法
JP2019509321A (ja) 2016-03-22 2019-04-04 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 疼痛を処置するための組み合わせ
CA3146163A1 (en) * 2019-07-08 2021-01-14 University Of Health Sciences & Pharmacy In St. Louis G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
US20230111856A1 (en) * 2020-03-02 2023-04-13 University Of Southern California Opioid receptor antagonists
CN115181109A (zh) * 2021-04-02 2022-10-14 南京正大天晴制药有限公司 吗啡喃衍生物的晶体及其制备方法
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WO2023190665A1 (ja) * 2022-03-29 2023-10-05 東レ株式会社 モルヒナン誘導体及びその医薬用途
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Also Published As

Publication number Publication date
DE69424853D1 (de) 2000-07-13
CA2143864C (en) 2006-01-24
WO1995003308A1 (en) 1995-02-02
ES2146654T3 (es) 2000-08-16
JP3843456B2 (ja) 2006-11-08
NZ268969A (en) 1997-06-24
EP0663401B1 (de) 2000-06-07
EP0663401A1 (de) 1995-07-19
US6177438B1 (en) 2001-01-23
CA2143864A1 (en) 1995-02-02
EP0663401A4 (de) 1996-06-26
AU686203B2 (en) 1998-02-05
AU7237394A (en) 1995-02-20

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