MXPA05003723A - Agentes terapeuticos o profilacticos para la frecuencia urinaria o incontinencia urinaria y derivados de morfinano que tienen grupo heterociclico que contiene nitrogeno. - Google Patents

Agentes terapeuticos o profilacticos para la frecuencia urinaria o incontinencia urinaria y derivados de morfinano que tienen grupo heterociclico que contiene nitrogeno.

Info

Publication number
MXPA05003723A
MXPA05003723A MXPA05003723A MXPA05003723A MXPA05003723A MX PA05003723 A MXPA05003723 A MX PA05003723A MX PA05003723 A MXPA05003723 A MX PA05003723A MX PA05003723 A MXPA05003723 A MX PA05003723A MX PA05003723 A MXPA05003723 A MX PA05003723A
Authority
MX
Mexico
Prior art keywords
urinary
diseases
nitrogen
urinary incontinence
preventives
Prior art date
Application number
MXPA05003723A
Other languages
English (en)
Inventor
Komagata Toshikazu
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of MXPA05003723A publication Critical patent/MXPA05003723A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se pretende proporcionar un derivado de morfinano representado por la siguiente formula general (I): (I) donde R1 representa metilo, ciclopropilmetilo, etc.; R2 y R3 representan cada uno hidroxi, metoxi, acetoxi, etc.; Y y Z representan cada uno un enlace de valencia, -(C=O)-, etc.; X representa una cadena de carbono de C2-5 que constituye parte de la estructura ciclica (donde uno de los atomos de carbono puede estar sustituido por oxigeno, azufre o nitrogeno); (R4)k representa un anillo de benceno fusionado opcionalmente sustituido, carbonilo etc.; R9 representa hidrogeno, etc.; R10 y R11 pueden estar unidos juntos para formar -0-; y R6 representa hidrogeno, etc.; una sal de adicion de acido farmacologicamente aceptable del mismo, un remedio o un preventivo para la frecuencia urinaria o incontinencia urinaria que contiene el derivado anterior o su sal de adicion de acido farmacologicamente aceptable como el ingrediente activo; y un metodo para tratar o prevenir las enfermedades anteriores; y utilizacion para esas enfermedades. Los compuestos descritos anteriormente son utiles como un remedio preventivo novedoso para la frecuencia urinaria o incontinencia urinaria que muestra un efecto secundario aislado. Ademas, es util en un metodo para tratar o prevenir las enfermedades anteriores y utilizacion para esas enfermedades.
MXPA05003723A 2002-10-09 2003-10-08 Agentes terapeuticos o profilacticos para la frecuencia urinaria o incontinencia urinaria y derivados de morfinano que tienen grupo heterociclico que contiene nitrogeno. MXPA05003723A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002295616 2002-10-09
PCT/JP2003/012890 WO2004033457A1 (ja) 2002-10-09 2003-10-08 頻尿もしくは尿失禁の治療または予防剤および含窒素環状置換基を有するモルヒナン誘導体

Publications (1)

Publication Number Publication Date
MXPA05003723A true MXPA05003723A (es) 2005-09-30

Family

ID=32089217

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05003723A MXPA05003723A (es) 2002-10-09 2003-10-08 Agentes terapeuticos o profilacticos para la frecuencia urinaria o incontinencia urinaria y derivados de morfinano que tienen grupo heterociclico que contiene nitrogeno.

Country Status (17)

Country Link
US (1) US7320984B2 (es)
EP (1) EP1555266B1 (es)
JP (1) JP4016986B2 (es)
KR (1) KR101060629B1 (es)
CN (1) CN100537573C (es)
AU (1) AU2003272944B2 (es)
BR (1) BR0314754A (es)
CA (1) CA2501389C (es)
ES (1) ES2479042T3 (es)
HK (1) HK1079786B (es)
IL (1) IL166944A (es)
MA (1) MA27454A1 (es)
MX (1) MXPA05003723A (es)
NO (1) NO20052167L (es)
NZ (1) NZ539199A (es)
WO (1) WO2004033457A1 (es)
ZA (1) ZA200502650B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060177381A1 (en) * 2002-02-15 2006-08-10 Howard Brooks-Korn Opiopathies
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
KR101233289B1 (ko) * 2004-03-30 2013-02-14 도레이 카부시키가이샤 지양제
TW200621785A (en) * 2004-11-04 2006-07-01 Toray Industries Analgesic
WO2006104280A1 (ja) * 2005-03-31 2006-10-05 Takeda Pharmaceutical Company Limited 糖尿病の予防・治療剤
JP5119925B2 (ja) 2005-11-09 2013-01-16 東レ株式会社 機能性腸障害の治療または予防剤
EP1974731B1 (en) * 2005-12-21 2011-07-13 Toray Industries, Inc. Morphinan derivatives for use as antitussive agents
US8927011B2 (en) 2007-05-21 2015-01-06 Toray Industries, Inc. Method for producing pharmaceutical tablet
WO2008143239A1 (ja) 2007-05-21 2008-11-27 Toray Industries, Inc. 結晶性微粉化粒子
RU2472539C2 (ru) 2007-08-06 2013-01-20 Аллерган, Инк. Способы и устройства для доставки препарата десмопрессина
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
EP3225249B1 (en) * 2008-05-21 2018-11-07 Ferring B.V. Orodispersible desmopressin for increasing initial period of sleep undisturbed by nocturia
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
TR201802379T4 (tr) * 2008-10-24 2018-03-21 Toray Industries 4,5-epoksimorfinan türevi içeren stabil tablet.
EP2387577A4 (en) * 2009-01-16 2012-10-17 Univ Virginia Commonwealth STRONG AND SELECTIVE NON-PEPTIDYL MU OPIOID RECEPTOR ANTAGONISTS
US8623888B2 (en) * 2009-07-15 2014-01-07 Mallinckrodt Llc 3-oxy-hydromorphone derivatives
WO2011154827A2 (en) 2010-06-11 2011-12-15 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
EP3458061B1 (en) 2016-05-19 2023-01-18 Virginia Commonwealth University Potent and selective mu opioid receptor modulators
US20210015813A1 (en) 2018-03-08 2021-01-21 Victoria Link Ltd. Treatment of demyelinating diseases
CN109970747B (zh) * 2019-05-05 2020-07-24 潍坊科技学院 一种制备10α-羟基纳呋拉啡的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3318884A (en) * 1965-07-21 1967-05-09 American Cyanamid Co Substituted 6-amino-6-demethoxythebaine and 6-amino-6-demethoxyoripavine derivatives
US6323212B1 (en) * 1992-01-23 2001-11-27 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications
EP0663401B1 (en) 1993-07-23 2000-06-07 Toray Industries, Inc. Morphinan derivative and medicinal use
ATE259232T1 (de) * 1995-03-03 2004-02-15 Endo Pharmaceuticals Inc Verwendung von dextromethorphan oder dextrorphan zur behandlung der harninkontinenz
WO2001005795A1 (fr) * 1999-07-19 2001-01-25 Toray Industries, Inc. Moyens de traitement et de prevention contre la miction frequente et l'incontinence d'urine
WO2002080918A1 (fr) * 2001-04-02 2002-10-17 Toray Industries, Inc. Agent therapeutique ou prophylactique en cas de miction frequente ou d'incontinence urinaire

Also Published As

Publication number Publication date
ES2479042T3 (es) 2014-07-23
CN100537573C (zh) 2009-09-09
NO20052167L (no) 2005-06-16
NZ539199A (en) 2008-09-26
US20060040970A1 (en) 2006-02-23
AU2003272944B2 (en) 2009-11-12
MA27454A1 (fr) 2005-07-01
JPWO2004033457A1 (ja) 2006-04-27
KR20050056232A (ko) 2005-06-14
JP4016986B2 (ja) 2007-12-05
CA2501389A1 (en) 2004-04-22
BR0314754A (pt) 2005-07-26
CN1703415A (zh) 2005-11-30
IL166944A (en) 2010-11-30
EP1555266A1 (en) 2005-07-20
CA2501389C (en) 2013-01-08
US7320984B2 (en) 2008-01-22
ZA200502650B (en) 2006-06-28
EP1555266B1 (en) 2014-05-21
KR101060629B1 (ko) 2011-08-31
EP1555266A4 (en) 2006-12-06
HK1079786A1 (en) 2006-04-13
WO2004033457A1 (ja) 2004-04-22
HK1079786B (zh) 2010-03-12
AU2003272944A1 (en) 2004-05-04

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