AU2001252596A1 - Melanin concentrating hormone antagonists - Google Patents

Melanin concentrating hormone antagonists

Info

Publication number
AU2001252596A1
AU2001252596A1 AU2001252596A AU5259601A AU2001252596A1 AU 2001252596 A1 AU2001252596 A1 AU 2001252596A1 AU 2001252596 A AU2001252596 A AU 2001252596A AU 5259601 A AU5259601 A AU 5259601A AU 2001252596 A1 AU2001252596 A1 AU 2001252596A1
Authority
AU
Australia
Prior art keywords
substituted
concentrating hormone
nitrogen atom
hormone antagonists
adjacent nitrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001252596A
Inventor
Yuji Ishihara
Nobuhiro Suzuki
Shiro Takekawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of AU2001252596A1 publication Critical patent/AU2001252596A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/66—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems and singly-bound oxygen atoms, bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/30—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

A melanin-concentrating hormone antagonist comprising a compound of the formula (I): <CHEM> wherein Ar<1> is a cyclic group which may be substituted; X and Y are the same or different and are a spacer having a main chain of 1 to 6 atoms; Ar is a condensed polycyclic aromatic ring which may be substituted; R<1> and R<2> are the same or different and are hydrogen atom or a hydrocarbon group which may be substituted; or R<1> and R<2>, together with the adjacent nitrogen atom, may form a nitrogen-containing heterocyclic ring which may be substituted; or R<2>, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing heterocyclic ring which may be substituted; or R<2>, together with the adjacent nitrogen atom, Y and Ar, may form a condensed ring; or a salt thereof is useful as an agent for preventing or treating obesity, etc.
AU2001252596A 2000-04-28 2001-04-26 Melanin concentrating hormone antagonists Abandoned AU2001252596A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2000134295 2000-04-28
JP2000-134295 2000-04-28
JP2000384897 2000-12-13
JP2000-384897 2000-12-13
PCT/JP2001/003614 WO2001082925A1 (en) 2000-04-28 2001-04-26 Melanin concentrating hormone antagonists

Publications (1)

Publication Number Publication Date
AU2001252596A1 true AU2001252596A1 (en) 2001-11-12

Family

ID=26591465

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001252596A Abandoned AU2001252596A1 (en) 2000-04-28 2001-04-26 Melanin concentrating hormone antagonists

Country Status (9)

Country Link
US (1) US6930185B2 (en)
EP (1) EP1285651B1 (en)
AT (1) ATE479429T1 (en)
AU (1) AU2001252596A1 (en)
CA (1) CA2407149C (en)
DE (1) DE60142961D1 (en)
DK (1) DK1285651T3 (en)
PT (1) PT1285651E (en)
WO (1) WO2001082925A1 (en)

Families Citing this family (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1186588A4 (en) * 1999-05-26 2003-01-22 Mitsubishi Chem Corp 6-hydroxy-2-naphthylcarbinol and process for the preparation thereof
CA2414198A1 (en) 2000-07-06 2002-01-17 Neurogen Corporation Melanin concentrating hormone receptor ligands
MXPA03010612A (en) 2001-05-22 2004-04-02 Neurogen Corp Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues.
RU2004115737A (en) * 2001-10-25 2005-10-10 Такеда Кемикал Индастриз, Лтд. (JP) Quinoline Compound
KR20040058307A (en) 2001-11-26 2004-07-03 쉐링 코포레이션 Piperidine-based MCH antagonists for treatment of obesity and CNS disorders
CA2468015A1 (en) 2001-11-27 2003-06-05 Merck & Co., Inc. 2-aminoquinoline compounds
US7160879B2 (en) 2002-01-10 2007-01-09 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues
EP1465888A2 (en) 2002-01-10 2004-10-13 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted benzoimidazole analogues
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
SE0202134D0 (en) * 2002-07-08 2002-07-08 Astrazeneca Ab Therapeutic agents
AU2003252715B2 (en) 2002-07-30 2009-06-04 Banyu Pharmaceutical Co., Ltd. Antagonist of melanin-concentrating hormone receptor comprising benzimidazole derivative as active ingredient
AU2003254852A1 (en) 2002-08-08 2004-02-25 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds as peptidase inhibitors
AU2003266668A1 (en) * 2002-09-30 2004-04-23 Banyu Pharmaceutical Co., Ltd. 2-aminobenzimidazole derivative
US7452911B2 (en) 2002-10-31 2008-11-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
DE10250708A1 (en) * 2002-10-31 2004-05-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg New alkyne compounds having MCH antagonist activity and medicaments containing these compounds
AU2003277576A1 (en) 2002-11-08 2004-06-07 Takeda Pharmaceutical Company Limited Receptor function controlling agent
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CA2515717A1 (en) 2003-02-10 2004-08-19 Banyu Pharmaceutical Co., Ltd. Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient
WO2004072018A1 (en) * 2003-02-12 2004-08-26 Takeda Pharmaceutical Company Limited Amine derivative
US7067509B2 (en) 2003-03-07 2006-06-27 Neurocrine Biosciences, Inc. Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto
EP1464335A3 (en) * 2003-03-31 2007-05-09 Taisho Pharmaceutical Co. Ltd. Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist
CA2521832A1 (en) * 2003-04-11 2004-10-28 Smithkline Beecham Corporation Heterocyclic mchr1 antagonists
WO2004103954A1 (en) 2003-05-20 2004-12-02 Ajinomoto Co., Inc. Amide derivative
CA2526374A1 (en) 2003-05-21 2004-12-02 Banyu Pharmaceutical Co., Ltd. 2-aminoquinoline derivatives
MY142655A (en) 2003-06-12 2010-12-15 Euro Celtique Sa Therapeutic agents useful for treating pain
CN1856484B (en) * 2003-07-24 2010-09-22 欧洲凯尔蒂克公司 Therapeutic agents useful for treating or preventing pain
CN100418965C (en) * 2003-08-15 2008-09-17 万有制药株式会社 Imidazopyridine derivatives
JP4765627B2 (en) 2003-09-22 2011-09-07 Ｍｓｄ株式会社 Novel piperidine derivatives
CN101068773A (en) * 2003-10-01 2007-11-07 宝洁公司 Melanin concentrating hormone antagonists
US20060247239A1 (en) * 2003-10-01 2006-11-02 Hu Xiufeng E Melanin concentrating hormone antagonists
WO2005040824A2 (en) * 2003-10-24 2005-05-06 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 24 (gpr24)
ZA200602056B (en) 2003-10-31 2007-05-30 Takeda Pharmaceutical Solid preparation comprising an insulin sensitizer, an insulin secretagogue and a polyoxyethylene sorbitan fatty acid ester
US7592373B2 (en) 2003-12-23 2009-09-22 Boehringer Ingelheim International Gmbh Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
EP1741703A4 (en) * 2004-03-05 2009-11-25 Banyu Pharma Co Ltd Pyridone derivative
US7605176B2 (en) 2004-03-06 2009-10-20 Boehringer Ingelheim International Gmbh β-ketoamide compounds with MCH antagonistic activity
DE102004010893A1 (en) * 2004-03-06 2005-09-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg New β-ketoamide compounds having MCH antagonist activity and medicaments containing these compounds
JP4859665B2 (en) 2004-03-30 2012-01-25 武田薬品工業株式会社 Alkoxyphenylpropanoic acid derivatives
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc Method of treating men with metabolic and anthropometric disorders
DE102004017934A1 (en) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg New alkyne compounds having MCH antagonist activity and medicaments containing these compounds
US20050245529A1 (en) * 2004-04-14 2005-11-03 Boehringer Ingelheim International Gmbh Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
US7524862B2 (en) 2004-04-14 2009-04-28 Boehringer Ingelheim International Gmbh Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
DE102004017930A1 (en) * 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg New alkyne compounds having MCH antagonist activity and medicaments containing these compounds
WO2005108370A1 (en) * 2004-04-16 2005-11-17 Ajinomoto Co., Inc. Benzene compounds
CN1950372A (en) * 2004-05-10 2007-04-18 万有制药株式会社 Imidazopyridine compound
CN101065356A (en) 2004-10-01 2007-10-31 万有制药株式会社 2-arylcarboxamide-nitrogenous heterocycle compound
EP2127676A3 (en) 2004-11-01 2013-09-04 Amylin Pharmaceuticals, LLC Treatment of obesity and related disorders
US8394765B2 (en) * 2004-11-01 2013-03-12 Amylin Pharmaceuticals Llc Methods of treating obesity with two different anti-obesity agents
CA2589678A1 (en) * 2004-12-17 2006-06-22 Eli Lilly And Company Novel mch receptor antagonists
TWI441819B (en) 2005-01-07 2014-06-21 Synta Pharmaceuticals Corp Compounds for inflammation and immune-related uses
JP5094394B2 (en) 2005-04-20 2012-12-12 武田薬品工業株式会社 Fused heterocyclic compounds
JP5000490B2 (en) 2005-04-28 2012-08-15 武田薬品工業株式会社 Thienopyrimidone compounds
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
CA2609388C (en) 2005-05-30 2013-08-06 Banyu Pharmaceutical Co., Ltd. Novel piperidine derivative
EP1897558B1 (en) 2005-06-09 2013-09-04 Norgine BV Solid preparation of 2-hexadecyloxy-6-methyl-4h-3,1-benzoxazin-4-one
JPWO2007018248A1 (en) * 2005-08-10 2009-02-19 萬有製薬株式会社 Pyridone compounds
BRPI0614649A2 (en) 2005-08-11 2011-04-12 Amylin Pharmaceuticals Inc hybrid polypeptides with selectable properties
EP1922336B1 (en) 2005-08-11 2012-11-21 Amylin Pharmaceuticals, LLC Hybrid polypeptides with selectable properties
AU2006282260A1 (en) 2005-08-24 2007-03-01 Msd K.K. Phenylpyridone derivative
JP2007063225A (en) 2005-09-01 2007-03-15 Takeda Chem Ind Ltd Imidazopyridine compound
CA2621470A1 (en) 2005-09-07 2007-03-15 Banyu Pharmaceutical Co., Ltd. Bicyclic aromatic substituted pyridone derivative
AU2006297443B2 (en) 2005-09-29 2010-08-12 Merck Sharp & Dohme Corp. Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
US20080255084A1 (en) 2005-10-21 2008-10-16 Randy Lee Webb Combination of Organic Compounds
CA2626747A1 (en) * 2005-10-26 2007-05-03 Boehringer Ingelheim International Gmbh (hetero)aryl compounds with mch antagonistic activity and medicaments comprising these compounds
EP1944301A4 (en) 2005-10-27 2012-01-04 Msd Kk Novel benzoxathiin derivative
MY146564A (en) 2005-11-10 2012-08-30 Msd Kk Aza-substituted spiro derivatives
MEP7609A (en) 2005-12-28 2011-12-20 Therapeutic agent for diabetes
JPWO2007119833A1 (en) 2006-04-14 2009-08-27 武田薬品工業株式会社 Nitrogen-containing heterocyclic compounds
WO2008001931A2 (en) 2006-06-27 2008-01-03 Takeda Pharmaceutical Company Limited Fused cyclic compounds
WO2008001778A1 (en) 2006-06-27 2008-01-03 Takeda Pharmaceutical Company Limited Genetically modified animal and use thereof
WO2008016131A1 (en) 2006-08-04 2008-02-07 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
WO2008022979A1 (en) 2006-08-25 2008-02-28 Boehringer Ingelheim International Gmbh New pyridone derivatives with mch antagonistic activity and medicaments comprising these compounds
US8173629B2 (en) 2006-09-22 2012-05-08 Merck Sharp & Dohme Corp. Method of treatment using fatty acid synthesis inhibitors
AU2007301126A1 (en) * 2006-09-28 2008-04-03 Banyu Pharmaceutical Co., Ltd. Diaryl ketimine derivative
WO2008041090A1 (en) * 2006-10-06 2008-04-10 Pfizer Limited Malanin concentrating hormone receptor-1 antagonist pyridinones
WO2008047821A1 (en) 2006-10-18 2008-04-24 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
US8410087B2 (en) 2006-10-19 2013-04-02 Takeda Pharmaceutical Company Limited Indole compound
MX2009004314A (en) 2006-11-13 2009-05-05 Pfizer Prod Inc Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof.
EP2256115A1 (en) 2006-11-24 2010-12-01 Takeda Pharmaceutical Company Limited Heteromonocyclic compound and use thereof
CA2671984A1 (en) 2006-12-11 2008-06-19 Boehringer Ingelheim International Gmbh New pyridazine derivatives with mch antagonistic activity and medicaments comprising these compounds
JPWO2008090944A1 (en) 2007-01-25 2010-05-20 武田薬品工業株式会社 Spiro ring compound
US20100016396A1 (en) 2007-01-29 2010-01-21 Hiroshi Imoto Pyrazole compound
EP2123652A1 (en) 2007-02-20 2009-11-25 Takeda Pharmaceutical Company Limited Heterocyclic compound
EP2145884B1 (en) 2007-04-02 2014-08-06 Msd K.K. Indoledione derivative
MX2009011601A (en) * 2007-04-27 2009-11-10 Purdue Pharma Lp Therapeutic agents useful for treating pain.
WO2008136428A1 (en) 2007-04-27 2008-11-13 Takeda Pharmaceutical Company Limited Nitrogen-containing five-membered heterocyclic compound
JPWO2008143262A1 (en) 2007-05-21 2010-08-12 武田薬品工業株式会社 Heterocyclic compounds and uses thereof
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN101772513B (en) 2007-06-04 2013-11-13 协同医药品公司 Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
TW200914006A (en) 2007-07-12 2009-04-01 Takeda Pharmaceutical Coated preparation
AU2008276842C9 (en) 2007-07-19 2014-08-21 Takeda Pharmaceutical Company Limited Solid preparation comprising alogliptin and metformin hydrochloride
JP5374377B2 (en) 2007-10-18 2013-12-25 武田薬品工業株式会社 Heterocyclic compounds
WO2009057784A1 (en) 2007-11-01 2009-05-07 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2009064298A1 (en) * 2007-11-14 2009-05-22 Amylin Pharmaceuticals, Inc. Methods for treating obesity and obesity related diseases and disorders
US20100285121A1 (en) 2008-01-10 2010-11-11 Takeda Pharmaceutical Company Limited Capsule Formulation
EP2251326A4 (en) 2008-03-05 2011-08-31 Takeda Pharmaceutical Heterocyclic compound
JPWO2009119726A1 (en) 2008-03-28 2011-07-28 Ｍｓｄ株式会社 Diarylmethylamide derivatives having melanin-concentrating hormone receptor antagonistic activity
EP2261213A1 (en) * 2008-04-01 2010-12-15 Takeda Pharmaceutical Company Limited Heterocyclic compound
US8461348B2 (en) 2008-04-04 2013-06-11 Takeda Pharmaceutical Company Limited Heterocyclic derivative and use thereof
WO2009128481A1 (en) 2008-04-16 2009-10-22 武田薬品工業株式会社 Nitrogenated 5-membered heterocyclic compound
WO2009145286A1 (en) 2008-05-30 2009-12-03 武田薬品工業株式会社 Heterocyclic compound
ES2522968T3 (en) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (en) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders
MX2011000460A (en) * 2008-07-18 2011-03-15 Takeda Pharmaceutical Benzazepine derivatives and their use as hstamine h3 antagonists.
CA2731358A1 (en) 2008-07-30 2010-02-04 Banyu Pharmaceutical Co., Ltd. 5/5-or 5/6-membered condensed ring cycloalkylamine derivative
JPWO2010016552A1 (en) 2008-08-07 2012-01-26 武田薬品工業株式会社 Drugs for irritable bowel syndrome
US8048307B2 (en) * 2008-08-14 2011-11-01 Brent Lee Dynamic filtration device using centrifugal force
MX2011004258A (en) 2008-10-22 2011-06-01 Merck Sharp & Dohme Novel cyclic benzimidazole derivatives useful anti-diabetic agents.
JP5535931B2 (en) 2008-10-27 2014-07-02 武田薬品工業株式会社 Bicyclic compound
PE20110852A1 (en) 2008-10-30 2011-11-25 Merck Sharp & Dohme ISONICOTINAMIDE OREXIN RECEPTOR ANTAGONISTS
CN102271509A (en) 2008-10-31 2011-12-07 默沙东公司 Novel cyclic benzimidazole derivatives useful anti-diabetic agents
EP2379562A1 (en) 2008-12-16 2011-10-26 Schering Corporation Bicyclic pyranone derivatives as nicotinic acid receptor agonists
US20110245209A1 (en) 2008-12-16 2011-10-06 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
JPWO2010087454A1 (en) 2009-01-30 2012-08-02 武田薬品工業株式会社 Quinoline derivatives
JP2010254623A (en) 2009-04-24 2010-11-11 Takeda Chem Ind Ltd Crystal of benzoxazinone compound
JP5711151B2 (en) 2010-01-06 2015-04-30 武田薬品工業株式会社 Indole derivatives
WO2011083314A1 (en) * 2010-01-08 2011-07-14 Takeda Pharmaceutical Company Limited Benzazepine derivatives for the treatment of central nervous system disorders
JP2013520502A (en) 2010-02-25 2013-06-06 メルク・シャープ・エンド・ドーム・コーポレイション Novel cyclic benzimidazole derivatives that are useful anti-diabetic drugs
CA2797767A1 (en) 2010-04-27 2011-11-03 Takeda Pharmaceutical Company Limited Bicyclic compound derivatives and their use as acc inhibitors
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
BR112013013417A2 (en) 2010-11-30 2019-09-24 Takeda Pharmaceuticals Co compound, medicament, methods for inhibiting acetylco carboxylase in a mammal, and for prophylaxis or treatment of obesity or diabetes in a mammal, and use of a compound or salt
BR122021002201A8 (en) 2011-02-25 2023-04-11 Merck Sharp & Dohme COMPOUND, COMPOSITION, USE OF A COMPOUND, AND METHOD OF TREATMENT OF A DISORDER, CONDITION OR DISEASE
US8772277B2 (en) 2011-08-04 2014-07-08 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound
CA2851087C (en) 2011-10-07 2019-09-24 Takeda Pharmaceutical Company Limited 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases
AR088352A1 (en) 2011-10-19 2014-05-28 Merck Sharp & Dohme ANTAGONISTS OF THE RECEIVER OF 2-PIRIDILOXI-4-NITRILE OREXINE
EP2772485A4 (en) 2011-10-24 2015-06-10 Takeda Pharmaceutical Bicyclic compound
WO2013105676A1 (en) 2012-01-12 2013-07-18 Takeda Pharmaceutical Company Limited Benzimidazole derivatives as mch receptor antagonists
CN104254525B (en) 2012-02-24 2016-05-25 武田药品工业株式会社 Aromatic compound
CN104350040B (en) 2012-03-29 2016-06-01 武田药品工业株式会社 Aromatic compound
WO2013168760A1 (en) 2012-05-10 2013-11-14 武田薬品工業株式会社 Aromatic ring compound
US9440987B2 (en) 2012-05-10 2016-09-13 Takeda Pharmaceutical Company Limited Aromatic ring compound
US9630976B2 (en) 2012-07-03 2017-04-25 Ono Pharmaceutical Co., Ltd. Compound having agonistic activity on somatostatin receptor, and use thereof for medical purposes
MX2015001500A (en) 2012-08-02 2015-04-08 Merck Sharp & Dohme Antidiabetic tricyclic compounds.
WO2014061676A1 (en) 2012-10-16 2014-04-24 武田薬品工業株式会社 Heterocyclic compound
WO2014092100A1 (en) 2012-12-11 2014-06-19 武田薬品工業株式会社 Heterocyclic compound
CA2898482A1 (en) 2013-02-22 2014-08-28 Linda L. Brockunier Antidiabetic bicyclic compounds
US9605000B2 (en) 2013-03-14 2017-03-28 Takeda Pharmaceutical Company Limited Spiro azetidine isoxazole derivatives and their use as SSTR antagonists
WO2014139388A1 (en) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
JP2016514671A (en) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists and uses thereof
WO2014163162A1 (en) 2013-04-04 2014-10-09 武田薬品工業株式会社 Heterocyclic compound
WO2014163161A1 (en) 2013-04-04 2014-10-09 武田薬品工業株式会社 Heterocyclic compound
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
CA2917490A1 (en) 2013-07-09 2015-01-15 Takeda Pharmaceutical Company Limited Heterocyclic compound
PL3053916T3 (en) 2013-09-30 2019-06-28 Ono Pharmaceutical Co., Ltd. Compound having somatostatin receptor agonistic activity and pharmaceutical use thereof
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
DK3186242T3 (en) 2014-08-29 2021-12-20 Tes Pharma S R L ALFA-AMINO-BETA-CARBOXYMUCONSIDE-SEMIALDEHYDE-DECARBOXYLASE INHIBITORS
EP3526199B1 (en) 2016-10-14 2022-04-13 Tes Pharma S.r.l. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
WO2018106518A1 (en) 2016-12-06 2018-06-14 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
WO2018118670A1 (en) 2016-12-20 2018-06-28 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds
RU2019124888A (en) 2017-02-08 2021-03-10 Оно Фармасьютикал Ко., Лтд. A COMPOUND WITH AGONISTIC ACTIVITY AGAINST THE SOMATOSTATIN RECEPTOR AND ITS PHARMACEUTICAL APPLICATION
KR20210111248A (en) 2018-11-20 2021-09-10 테스 파마 에스.알.엘. Inhibitors of α-amino-β-carboxymuconic acid semialdehyde decarboxylase
EP3924058A1 (en) 2019-02-13 2021-12-22 Merck Sharp & Dohme Corp. 5-alkyl pyrrolidine orexin receptor agonists
WO2021026047A1 (en) 2019-08-08 2021-02-11 Merck Sharp & Dohme Corp. Heteroaryl pyrrolidine and piperidine orexin receptor agonists
MX2023001840A (en) 2020-08-18 2023-03-13 Merck Sharp & Dohme Llc Bicycloheptane pyrrolidine orexin receptor agonists.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2502588A1 (en) 1975-01-23 1976-07-29 Troponwerke Dinklage & Co Coronary dilating 7-amino-2-quinolone derivs - prepd. e.g. by reacting 1,3-phenylenediamines with aminoalkyl-substd. acetoacetates
GB9119920D0 (en) 1991-09-18 1991-10-30 Glaxo Group Ltd Chemical compounds
JPH07179407A (en) 1993-11-12 1995-07-18 Green Cross Corp:The New condensed cyclic compound or its salt and its medicinal use
WO1995032967A1 (en) * 1994-05-28 1995-12-07 Smithkline Beecham Plc Amide derivatives having 5ht1d-antagonist activity
HUP9904682A3 (en) 1996-10-07 2001-09-28 Lilly Co Eli Phenyloxazole and -thiazole derivatives, their use and pharmaceutical compositions containing them
DE69839305T2 (en) * 1997-02-27 2009-04-09 Takeda Pharmaceutical Co. Ltd. AMIN DERIVATIVES, THEIR PREPARATION AND USE AS INHIBITORS OF THE PRODUCTION OF AMYLOID BETA
US6534496B1 (en) 1997-04-17 2003-03-18 Takeda Chemical Industries, Inc. Thermogenic composition and benzazepine thermogenics
AU5265599A (en) * 1998-04-08 1999-11-01 Takeda Chemical Industries Ltd. Amine compounds, their production and their use as somatostatin receptor antagonists or agonists
EP1122252A4 (en) 1998-10-16 2002-06-26 Takeda Chemical Industries Ltd Nitrogenous fused heterocycle compounds, process for the preparation thereof and agents containing the same
US6586475B1 (en) * 1998-11-20 2003-07-01 Takeda Chemical Industries, Ltd. β-amyloid protein production/secretion inhibitors
DE69935159T2 (en) * 1998-12-28 2007-10-25 Takeda Pharmaceutical Co. Ltd. SCREENING PROCESS
EP1218336A2 (en) * 1999-09-20 2002-07-03 Takeda Chemical Industries, Ltd. Melanin concentrating hormone antagonist

Also Published As

Publication number Publication date
US20040077628A1 (en) 2004-04-22
DK1285651T3 (en) 2010-12-13
DE60142961D1 (en) 2010-10-14
CA2407149C (en) 2010-10-12
EP1285651A1 (en) 2003-02-26
CA2407149A1 (en) 2001-11-08
US6930185B2 (en) 2005-08-16
PT1285651E (en) 2010-10-21
WO2001082925A1 (en) 2001-11-08
EP1285651B1 (en) 2010-09-01
EP1285651A4 (en) 2005-04-27
ATE479429T1 (en) 2010-09-15

Similar Documents

Publication Publication Date Title
AU2001252596A1 (en) Melanin concentrating hormone antagonists
WO2001021577A3 (en) Melanin concentrating hormone antagonist
EP1283199A4 (en) Melanin-concentrating hormone antagonist
ATE303387T1 (en) CONDENSED IMIDAZOLE DERIVATIVES AND DRUGS FOR DIABETES MELLITUS
DE60135764D1 (en) NITROGENIC, FIVE-GLASS RING COMPOUNDS
UA83243C2 (en) Compounds having inhibitory activity against sodium-dependant transporter
BR0315815A (en) Agents for preventing or treating neuropathy, for promoting the production or secretion of a neurotropic factor, for improving pain, neuroprotective and pharmaceutical compound, methods for preventing or treating neuropathy and for promoting the production or secretion of a neurotropic factor. improve pain to protect a nerve in a mammal and produce a compound and use of a compound
CA2286723A1 (en) Tricyclic compounds
DK0870768T3 (en) Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents
UA88329C2 (en) Dna-pk inhibitors
EP1184373A4 (en) Tricyclic compounds
TW200600085A (en) External preparation
ATE383340T1 (en) UNSYMMETRIC CYCLIC DIAMINE COMPOUND
AU7824900A (en) Compounds and methods for inhibiting mrp1
WO2002028853A1 (en) Benzylamine compound, process for producing the same, and intermediate therefor
EP0607864A3 (en) Tricyclic condensed heterocyclic compounds for the treatment of senile dementic.
ATE202354T1 (en) TETRACYCLIC CONDENSED HETEROCYCLIC COMPOUNDS FOR TREATING SENILE DEMENTIA
EP0567090A3 (en)
AP2000002008A0 (en) Tetrahydroquinoline derivatives as glycine antagonists.
EP1134219A4 (en) Cycloalkyl-substituted aminomethylpyrrolidine derivatives
MY129094A (en) Condensed polycyclic compounds
DK1559714T3 (en) Process for Preparation of 2-alkyl-3-aminothiophene derivatives and 3-aminothiophene derivatives
EP1211253A4 (en) Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents
MY133207A (en) Substituted benzolactam compaunds
UA84052C2 (en) Coumarin derivative and use thereof