DE69424853D1 - Morphinan-derivate und ihre medizinische verwendung - Google Patents

Morphinan-derivate und ihre medizinische verwendung

Info

Publication number
DE69424853D1
DE69424853D1 DE69424853T DE69424853T DE69424853D1 DE 69424853 D1 DE69424853 D1 DE 69424853D1 DE 69424853 T DE69424853 T DE 69424853T DE 69424853 T DE69424853 T DE 69424853T DE 69424853 D1 DE69424853 D1 DE 69424853D1
Authority
DE
Germany
Prior art keywords
medical use
morphinan derivatives
morphinan
derivatives
medical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69424853T
Other languages
English (en)
Other versions
DE69424853T2 (de
Inventor
Hiroshi Nagase
Jun Hayakawa
Huniaki Kawamura
Koji Kawai
Takashi Endoh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of DE69424853D1 publication Critical patent/DE69424853D1/de
Publication of DE69424853T2 publication Critical patent/DE69424853T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
DE69424853T 1993-07-23 1994-07-20 Morphinan-derivate und ihre medizinische verwendung Expired - Fee Related DE69424853T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20212793 1993-07-23
PCT/JP1994/001197 WO1995003308A1 (en) 1993-07-23 1994-07-20 Morphinan derivative and medicinal use

Publications (2)

Publication Number Publication Date
DE69424853D1 true DE69424853D1 (de) 2000-07-13
DE69424853T2 DE69424853T2 (de) 2000-10-05

Family

ID=16452416

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69424853T Expired - Fee Related DE69424853T2 (de) 1993-07-23 1994-07-20 Morphinan-derivate und ihre medizinische verwendung

Country Status (9)

Country Link
US (1) US6177438B1 (de)
EP (1) EP0663401B1 (de)
JP (1) JP3843456B2 (de)
AU (1) AU686203B2 (de)
CA (1) CA2143864C (de)
DE (1) DE69424853T2 (de)
ES (1) ES2146654T3 (de)
NZ (1) NZ268969A (de)
WO (1) WO1995003308A1 (de)

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WO2002080918A1 (fr) * 2001-04-02 2002-10-17 Toray Industries, Inc. Agent therapeutique ou prophylactique en cas de miction frequente ou d'incontinence urinaire
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JP4016986B2 (ja) 2002-10-09 2007-12-05 東レ株式会社 頻尿もしくは尿失禁の治療または予防剤および含窒素環状置換基を有するモルヒナン誘導体
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US6852713B2 (en) * 2003-04-16 2005-02-08 Adolor Corporation Lactam derivatives and methods of their use
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US6992193B2 (en) 2003-06-10 2006-01-31 Adolor Corporation Sulfonylamino phenylacetamide derivatives and methods of their use
US7034051B2 (en) * 2003-08-28 2006-04-25 Adolor Corporation Fused bicyclic carboxamide derivatives and methods of their use
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AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
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TW200815451A (en) 2006-08-04 2008-04-01 Wyeth Corp 6-carboxy-normorphinan derivatives, synthesis and uses thereof
EP2137191B8 (de) 2007-03-29 2016-06-08 Progenics Pharmaceuticals, Inc. Antagonisten der peripheren opioidrezeptoren und ihre verwendung
DK2565195T3 (en) 2007-03-29 2015-06-29 Wyeth Llc PERIPHERAL OPIOID RECEPTOR AND ANTAGONISTS AND USES THEREOF
BRPI0809579B8 (pt) 2007-03-29 2021-05-25 Progenics Pharm Inc formas cristalinas e seus usos
JP5213157B2 (ja) * 2007-08-24 2013-06-19 学校法人北里研究所 ６，１４−エポキシモルヒナン誘導体およびその医薬用途
KR101173509B1 (ko) * 2007-10-05 2012-08-14 도레이 카부시키가이샤 모르피난 유도체 또는 그 약리학적으로 허용되는 산부가염을 유효 성분으로 하는 피부 성상 개선 치료약
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JP5697215B2 (ja) * 2009-06-11 2015-04-08 マリンクロッド エルエルシー 触媒的水素移動による６−α−アミノＮ−置換モルフィナンの合成
JP5680069B2 (ja) * 2009-06-11 2015-03-04 マリンクロッド エルエルシー 触媒的水素移動による６−ケトノルモルフィナンの還元アミノ化
AU2010273253B2 (en) * 2009-07-16 2015-03-12 Mallinckrodt Llc (+) - morphinans as antagonists of Toll-like receptor 9 and therapeutic uses thereof
CA2768199C (en) * 2010-07-16 2018-08-28 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
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EP2630150B1 (de) * 2010-10-19 2017-04-12 Memorial Sloan-Kettering Cancer Center 6-amido-derivat aus 4,5-a-epoxymorphinanen zur schmerzbehandlung
JP2014073964A (ja) * 2011-01-28 2014-04-24 Kitasato Institute モルヒナン誘導体
PL2718294T3 (pl) * 2011-06-09 2019-04-30 SpecGx LLC Redukcyjne aminowanie 6-keto morfinanów przez katalityczne przeniesienie wodoru
JP6138169B2 (ja) 2012-03-05 2017-05-31 ドクター レディズ ラボラトリーズ リミテッド κオピオイド受容体（ＫＯＲ）アゴニストとしての置換複素環式アセトアミド
WO2014021273A1 (ja) * 2012-07-30 2014-02-06 学校法人北里研究所 モルヒナン誘導体
TWI449704B (zh) * 2013-04-26 2014-08-21 Everlight Chem Ind Corp 嗎啡喃衍生物之結晶、其製造方法、及使用其之醫藥組成物
US9656962B2 (en) * 2013-12-26 2017-05-23 Purdue Pharma L.P. Ring-contracted morphinans and the use thereof
JPWO2016167318A1 (ja) * 2015-04-16 2018-02-08 学校法人北里研究所 記憶改善剤及びその使用
CA2983314A1 (en) 2015-04-30 2016-11-03 Memorial Sloan-Kettering Cancer Center Mitragynine analogs and uses thereof
SG11201803191VA (en) * 2015-10-29 2018-05-30 Univ Tsukuba Morphinan derivative and medical usage thereof
CN106866688B (zh) * 2015-12-10 2019-05-03 山东诚创医药技术开发有限公司 一种纳呋拉啡的精制方法
US11529340B2 (en) 2016-03-22 2022-12-20 Regents Of The University Of Minnesota Combination for treating pain
WO2021007366A1 (en) 2019-07-08 2021-01-14 St. Louis College Of Pharmacy G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
US20230111856A1 (en) * 2020-03-02 2023-04-13 University Of Southern California Opioid receptor antagonists
CN115181109A (zh) * 2021-04-02 2022-10-14 南京正大天晴制药有限公司 吗啡喃衍生物的晶体及其制备方法
IL309232A (en) 2021-06-14 2024-02-01 Scorpion Therapeutics Inc History of urea which can be used to treat cancer
CN114736210A (zh) * 2022-03-29 2022-07-12 伊诺药物研究(南京)有限公司 吗啡喃衍生物的一种晶型的制备方法
WO2023190665A1 (ja) * 2022-03-29 2023-10-05 東レ株式会社 モルヒナン誘導体及びその医薬用途
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Also Published As

Publication number Publication date
CA2143864C (en) 2006-01-24
ES2146654T3 (es) 2000-08-16
DE69424853T2 (de) 2000-10-05
EP0663401B1 (de) 2000-06-07
AU686203B2 (en) 1998-02-05
JP3843456B2 (ja) 2006-11-08
EP0663401A4 (de) 1996-06-26
EP0663401A1 (de) 1995-07-19
US6177438B1 (en) 2001-01-23
CA2143864A1 (en) 1995-02-02
NZ268969A (en) 1997-06-24
WO1995003308A1 (en) 1995-02-02
AU7237394A (en) 1995-02-20

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