DE69413933T2 - Antitussiva - Google Patents

Antitussiva

Info

Publication number
DE69413933T2
DE69413933T2 DE69413933T DE69413933T DE69413933T2 DE 69413933 T2 DE69413933 T2 DE 69413933T2 DE 69413933 T DE69413933 T DE 69413933T DE 69413933 T DE69413933 T DE 69413933T DE 69413933 T2 DE69413933 T2 DE 69413933T2
Authority
DE
Germany
Prior art keywords
antitussiva
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69413933T
Other languages
English (en)
Other versions
DE69413933D1 (de
Inventor
Hiroshi Nagase
Koji Kawai
Takashi Endoh
Shinya Ueno
Yuji Negishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of DE69413933D1 publication Critical patent/DE69413933D1/de
Publication of DE69413933T2 publication Critical patent/DE69413933T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
DE69413933T 1993-06-30 1994-06-28 Antitussiva Expired - Fee Related DE69413933T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16162693 1993-06-30
PCT/JP1994/001047 WO1995001178A1 (fr) 1993-06-30 1994-06-28 Antitussif

Publications (2)

Publication Number Publication Date
DE69413933D1 DE69413933D1 (de) 1998-11-19
DE69413933T2 true DE69413933T2 (de) 1999-04-08

Family

ID=15738765

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69413933T Expired - Fee Related DE69413933T2 (de) 1993-06-30 1994-06-28 Antitussiva

Country Status (11)

Country Link
US (1) US5739145A (de)
EP (1) EP0657163B1 (de)
KR (1) KR950702833A (de)
CN (1) CN1111900A (de)
AU (1) AU683664B2 (de)
CA (1) CA2143318A1 (de)
DE (1) DE69413933T2 (de)
FI (1) FI950908A (de)
NO (1) NO950757L (de)
TW (1) TW329386B (de)
WO (1) WO1995001178A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2525552B2 (ja) 1992-01-23 1996-08-21 東レ株式会社 モルヒナン誘導体および医薬用途
WO1995003307A1 (fr) * 1993-07-19 1995-02-02 Toray Industries, Inc. Agent de protection de cellules cerebrales
JP3843456B2 (ja) 1993-07-23 2006-11-08 東レ株式会社 モルヒナン誘導体および医薬用途
EP0829481A1 (de) * 1996-09-16 1998-03-18 Pfizer Inc. Morphinan-Hydroxamsäure-Derivate
ATE263563T1 (de) * 1996-11-25 2004-04-15 Toray Industries Mittel gegen juckreiz
US6440987B1 (en) 1996-11-25 2002-08-27 Toray Industries, Inc. Antipruritic
US6403602B1 (en) * 1997-02-20 2002-06-11 The University Of Kentucky Research Foundation Morphine-6-sulfate analogues and their use for the treatment of pain
CN1204139C (zh) * 1999-08-24 2005-06-01 东丽株式会社 神经性疼痛治疗剂
WO2002080918A1 (fr) * 2001-04-02 2002-10-17 Toray Industries, Inc. Agent therapeutique ou prophylactique en cas de miction frequente ou d'incontinence urinaire
PL1873158T3 (pl) 2005-04-06 2016-09-30 Kryształy pochodnej morfinanu i sposoby ich wytwarzania
MX2009011449A (es) 2007-04-24 2010-01-25 Toray Industries Agente terapeutico o profilactico para disquinesia.
ES2555785T3 (es) * 2007-06-22 2016-01-08 Toray Industries, Inc. Remedio o preventivo para esquizofrenia
EP2252150B1 (de) 2008-02-14 2018-04-11 Alkermes, Inc. Selektive opioidverbindungen
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8563724B2 (en) * 2009-02-23 2013-10-22 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
EP2398806A1 (de) * 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-morphinanium-n-oxide und verfahren zu ihrer herstellung
EP2398805A1 (de) * 2009-02-23 2011-12-28 Mallinckrodt LLC Quaternäre (+)-morphinaniumsalze und verfahren zu ihrer herstellung
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
ES2582628T3 (es) 2010-01-29 2016-09-14 Toray Industries, Inc. Agente terapéutico o profiláctico para enfermedades de las vías biliares
BR112013009505B1 (pt) * 2010-10-19 2022-06-21 Memorial Sloan-Kettering Cancer Center Composto, composição farmacêutica, métodos para ensaio quanto a um receptor, e, usos de um composto
MX2013008749A (es) 2011-01-31 2013-10-17 Toray Industries Agente terapeutico o profilactico para caquexia.
JP2014526467A (ja) 2011-09-08 2014-10-06 マリンクロッド エルエルシー 中間体の単離なしでのアルカロイドの調製
CA2983314A1 (en) 2015-04-30 2016-11-03 Memorial Sloan-Kettering Cancer Center Mitragynine analogs and uses thereof
CN105461727A (zh) * 2015-12-01 2016-04-06 吕涛 一种纳呋拉啡的精制方法
CN106866688B (zh) * 2015-12-10 2019-05-03 山东诚创医药技术开发有限公司 一种纳呋拉啡的精制方法
CN115181109A (zh) * 2021-04-02 2022-10-14 南京正大天晴制药有限公司 吗啡喃衍生物的晶体及其制备方法
CN114736210A (zh) * 2022-03-29 2022-07-12 伊诺药物研究(南京)有限公司 吗啡喃衍生物的一种晶型的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB843908A (en) * 1957-12-20 1960-08-10 Hoffmann La Roche Novel morphinan derivatives and the manufacture thereof
FR1503524A (fr) * 1964-10-17 1967-12-01 Tanabe Seiyaku Co Morphine à noyaux b/c condensés en configuration trans, et son procédé de préparation
US3865943A (en) * 1971-02-19 1975-02-11 Boehringer Sohn Ingelheim Pharmaceutical compositions containing an n-(furyl-methyl)-3-oxy-morphinan and method of use
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
US3880863A (en) * 1973-08-31 1975-04-29 Warner Lambert Co 17-Aralkyl-6 beta-azido-4,5 alpha-epox-ymorphinan-3-01{hu s
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
US4613668A (en) * 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US4730048A (en) * 1985-12-12 1988-03-08 Regents Of The University Of Minnesota Gut-selective opiates
US4912114A (en) * 1988-03-18 1990-03-27 Sandoz Ltd. Morphinan derivatives
EP0415693A1 (de) * 1989-08-28 1991-03-06 Arizona Technology Development Corporation Zusammensetzung und Verfahren zur selektiven Verstärkung der Opiat-Wirkung und Verminderung von Opiat-Toleranz und Abhängigkeit
JP2525552B2 (ja) * 1992-01-23 1996-08-21 東レ株式会社 モルヒナン誘導体および医薬用途

Also Published As

Publication number Publication date
EP0657163B1 (de) 1998-10-14
AU6984494A (en) 1995-01-24
AU683664B2 (en) 1997-11-20
FI950908A (fi) 1995-04-28
NO950757L (no) 1995-04-27
TW329386B (en) 1998-04-11
CA2143318A1 (en) 1995-01-12
EP0657163A4 (de) 1995-12-13
CN1111900A (zh) 1995-11-15
WO1995001178A1 (fr) 1995-01-12
US5739145A (en) 1998-04-14
NO950757D0 (no) 1995-02-27
EP0657163A1 (de) 1995-06-14
FI950908A0 (fi) 1995-02-28
KR950702833A (ko) 1995-08-23
DE69413933D1 (de) 1998-11-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee