TW329386B - Cough medicine - Google Patents

Cough medicine

Info

Publication number
TW329386B
TW329386B TW083105890A TW83105890A TW329386B TW 329386 B TW329386 B TW 329386B TW 083105890 A TW083105890 A TW 083105890A TW 83105890 A TW83105890 A TW 83105890A TW 329386 B TW329386 B TW 329386B
Authority
TW
Taiwan
Prior art keywords
group
methyl
formula
cough medicine
hydroxyl
Prior art date
Application number
TW083105890A
Other languages
English (en)
Inventor
Hiroshi Nagase
Takaharu Kawai
Takashi Endou
Shinya Ueno
Yuuji Negishi
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Application granted granted Critical
Publication of TW329386B publication Critical patent/TW329386B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW083105890A 1993-06-30 1994-06-29 Cough medicine TW329386B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16162693 1993-06-30

Publications (1)

Publication Number Publication Date
TW329386B true TW329386B (en) 1998-04-11

Family

ID=15738765

Family Applications (1)

Application Number Title Priority Date Filing Date
TW083105890A TW329386B (en) 1993-06-30 1994-06-29 Cough medicine

Country Status (11)

Country Link
US (1) US5739145A (zh)
EP (1) EP0657163B1 (zh)
KR (1) KR950702833A (zh)
CN (1) CN1111900A (zh)
AU (1) AU683664B2 (zh)
CA (1) CA2143318A1 (zh)
DE (1) DE69413933T2 (zh)
FI (1) FI950908A (zh)
NO (1) NO950757L (zh)
TW (1) TW329386B (zh)
WO (1) WO1995001178A1 (zh)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2525552B2 (ja) * 1992-01-23 1996-08-21 東レ株式会社 モルヒナン誘導体および医薬用途
DE69414085T2 (de) * 1993-07-19 1999-03-18 Toray Industries Wirkstoff zum schutze von gehirnzellen
CA2143864C (en) 1993-07-23 2006-01-24 Hiroshi Nagase Morphinan derivatives and pharmaceutical use thereof
EP0829481A1 (en) * 1996-09-16 1998-03-18 Pfizer Inc. Morphinan hydroxamic acid compounds
US6440987B1 (en) 1996-11-25 2002-08-27 Toray Industries, Inc. Antipruritic
DE69737592T2 (de) 1996-11-25 2008-01-03 Toray Industries, Inc. Mittel gegen juckreiz
US6403602B1 (en) * 1997-02-20 2002-06-11 The University Of Kentucky Research Foundation Morphine-6-sulfate analogues and their use for the treatment of pain
CA2383146C (en) * 1999-08-24 2010-11-16 Hiroshi Nagase Therapeutic agent for neuropathic pain and neuropathic pain animal model
WO2002080918A1 (fr) * 2001-04-02 2002-10-17 Toray Industries, Inc. Agent therapeutique ou prophylactique en cas de miction frequente ou d'incontinence urinaire
PL1873158T3 (pl) * 2005-04-06 2016-09-30 Kryształy pochodnej morfinanu i sposoby ich wytwarzania
MX2009011449A (es) 2007-04-24 2010-01-25 Toray Industries Agente terapeutico o profilactico para disquinesia.
PL2168580T3 (pl) * 2007-06-22 2016-06-30 Toray Industries Środek do leczenia lub zapobiegania schizofrenii
CA2714331C (en) 2008-02-14 2016-08-09 Alkermes, Inc. Selective opioid compounds
JP2012518652A (ja) * 2009-02-23 2012-08-16 マリンクロッド インコーポレイテッド （＋）−６−ヒドロキシ−モルフィナンまたは（＋）−６−アミノ−モルフィナン誘導体
CN102325776A (zh) * 2009-02-23 2012-01-18 马林克罗特公司 (+)-吗啡喃*季盐及其制备方法
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
WO2010096790A1 (en) * 2009-02-23 2010-08-26 Mallinckrodt Inc. (+)-morphinananium n-oxides and processes for their production
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
KR101732042B1 (ko) 2010-01-29 2017-05-02 도레이 카부시키가이샤 담도 질환의 치료 또는 예방제
CA2814795C (en) * 2010-10-19 2018-02-27 Memorial Sloan-Kettering Cancer Center 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain
ES2586655T3 (es) 2011-01-31 2016-10-18 Toray Industries, Inc. (-)-17-(ciclopropilmetil)-3,14beta-dihidroxi-4,5alfa-epoxi-6beta-[N-metil-trans-3-(3-furil)acrilamido]morfinano para su utilización en el tratamiento o prevención de la caquexia por cáncer
ES2566620T3 (es) 2011-09-08 2016-04-14 Mallinckrodt Llc Procesamiento de alcaloides sin el aislamiento de intermedios
US11046692B2 (en) 2015-04-30 2021-06-29 Memorial Sloan-Kettering Cancer Center Mitragynine analogs and uses thereof
CN105461727A (zh) * 2015-12-01 2016-04-06 吕涛 一种纳呋拉啡的精制方法
CN106866688B (zh) * 2015-12-10 2019-05-03 山东诚创医药技术开发有限公司 一种纳呋拉啡的精制方法
CN115181109B (zh) * 2021-04-02 2024-06-04 南京正大天晴制药有限公司 吗啡喃衍生物的晶体及其制备方法
CN114736210A (zh) * 2022-03-29 2022-07-12 伊诺药物研究(南京)有限公司 吗啡喃衍生物的一种晶型的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB843908A (en) * 1957-12-20 1960-08-10 Hoffmann La Roche Novel morphinan derivatives and the manufacture thereof
FR1503524A (fr) * 1964-10-17 1967-12-01 Tanabe Seiyaku Co Morphine à noyaux b/c condensés en configuration trans, et son procédé de préparation
US3865943A (en) * 1971-02-19 1975-02-11 Boehringer Sohn Ingelheim Pharmaceutical compositions containing an n-(furyl-methyl)-3-oxy-morphinan and method of use
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
US3880863A (en) * 1973-08-31 1975-04-29 Warner Lambert Co 17-Aralkyl-6 beta-azido-4,5 alpha-epox-ymorphinan-3-01{hu s
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
US4613668A (en) * 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US4730048A (en) * 1985-12-12 1988-03-08 Regents Of The University Of Minnesota Gut-selective opiates
US4912114A (en) * 1988-03-18 1990-03-27 Sandoz Ltd. Morphinan derivatives
JPH03163030A (ja) * 1989-08-28 1991-07-15 Arizona Technol Dev Corp アヘン剤活性を選択的に強化し、アヘン剤耐性と依存性を軽減するための組成物と方法
JP2525552B2 (ja) * 1992-01-23 1996-08-21 東レ株式会社 モルヒナン誘導体および医薬用途

Also Published As

Publication number Publication date
CA2143318A1 (en) 1995-01-12
US5739145A (en) 1998-04-14
AU6984494A (en) 1995-01-24
FI950908A (fi) 1995-04-28
EP0657163A1 (en) 1995-06-14
EP0657163A4 (en) 1995-12-13
AU683664B2 (en) 1997-11-20
DE69413933T2 (de) 1999-04-08
NO950757D0 (no) 1995-02-27
CN1111900A (zh) 1995-11-15
DE69413933D1 (de) 1998-11-19
EP0657163B1 (en) 1998-10-14
WO1995001178A1 (fr) 1995-01-12
FI950908A0 (fi) 1995-02-28
NO950757L (no) 1995-04-27
KR950702833A (ko) 1995-08-23

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