AU669122B2 - New pyrazine derivatives, their preparation and their use - Google Patents
New pyrazine derivatives, their preparation and their useInfo
- Publication number
- AU669122B2 AU669122B2 AU23870/92A AU2387092A AU669122B2 AU 669122 B2 AU669122 B2 AU 669122B2 AU 23870/92 A AU23870/92 A AU 23870/92A AU 2387092 A AU2387092 A AU 2387092A AU 669122 B2 AU669122 B2 AU 669122B2
- Authority
- AU
- Australia
- Prior art keywords
- preparation
- pyrazine derivatives
- new pyrazine
- new
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Disclosed are new compounds of formula (I) (R<1> to R<6> being defined in the description) which can be prepared by conventional methods. The compounds are suitable for use as active ingredients in drugs.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4127026A DE4127026A1 (en) | 1991-08-16 | 1991-08-16 | New 3-amino-6-chloro:pyrazine 2-carboxamide derivs. - useful as hypotensive, mucolytic, diuretic and antitumoural drugs |
DE4127026 | 1991-08-16 | ||
DE4130461 | 1991-09-13 | ||
DE19914130461 DE4130461A1 (en) | 1991-09-13 | 1991-09-13 | New 3-amino-5-substd. carboxamide chloro-pyrazine carbamide cpds. |
PCT/EP1992/001738 WO1993004048A1 (en) | 1991-08-16 | 1992-07-31 | New pyrazine derivatives, their preparation and their use |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2387092A AU2387092A (en) | 1993-03-16 |
AU669122B2 true AU669122B2 (en) | 1996-05-30 |
Family
ID=25906394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU23870/92A Ceased AU669122B2 (en) | 1991-08-16 | 1992-07-31 | New pyrazine derivatives, their preparation and their use |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP0598770B1 (en) |
JP (1) | JPH06509798A (en) |
AT (1) | ATE159250T1 (en) |
AU (1) | AU669122B2 (en) |
CA (1) | CA2115755A1 (en) |
CZ (1) | CZ280760B6 (en) |
DE (1) | DE59208974D1 (en) |
DK (1) | DK0598770T3 (en) |
ES (1) | ES2108129T3 (en) |
FI (1) | FI940696A0 (en) |
GR (1) | GR3025742T3 (en) |
HK (1) | HK1003137A1 (en) |
HU (1) | HUT67661A (en) |
IE (1) | IE922592A1 (en) |
IL (1) | IL102814A0 (en) |
MX (1) | MX9204637A (en) |
NO (1) | NO301542B1 (en) |
NZ (1) | NZ243959A (en) |
RU (1) | RU2124008C1 (en) |
SG (1) | SG46307A1 (en) |
SK (1) | SK17594A3 (en) |
TW (1) | TW213903B (en) |
WO (1) | WO1993004048A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6645969B1 (en) | 1991-05-10 | 2003-11-11 | Aventis Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL109570A0 (en) * | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
DE4325822A1 (en) * | 1993-07-31 | 1995-02-02 | Hoechst Ag | Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them |
US5852046A (en) * | 1993-08-03 | 1998-12-22 | Hoechst Aktiengesellschaft | Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them |
DE4337609A1 (en) * | 1993-11-04 | 1995-05-11 | Boehringer Ingelheim Kg | Novel pyrazinecarboxamide derivatives, their preparation and their use in medicines |
DE4412334A1 (en) * | 1994-04-11 | 1995-10-19 | Hoechst Ag | Substituted N-heteroaroylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
US5760230A (en) * | 1996-10-11 | 1998-06-02 | Bayer Aktiengesellschaft | 4, 4'-bridged bis-2, 4-diaminoquinazolines |
US6420354B1 (en) * | 1998-06-08 | 2002-07-16 | Advanced Medicine, Inc. | Sodium channel drugs and uses |
WO2000075115A1 (en) | 1999-06-03 | 2000-12-14 | Takeda Chemical Industries, Ltd. | Pernasal preparations |
US6479498B1 (en) | 1999-06-04 | 2002-11-12 | Theravance, Inc. | Sodium channel drugs and uses |
US6156758A (en) * | 1999-09-08 | 2000-12-05 | Isis Pharmaceuticals, Inc. | Antibacterial quinazoline compounds |
EP1485370B1 (en) * | 2002-03-13 | 2009-03-04 | Janssen Pharmaceutica N.V. | Amino-derivatives as novel inhibitors of histone deacetylase |
WO2006074147A2 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics, Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
JP2007504136A (en) | 2003-08-28 | 2007-03-01 | ニトロメッド インコーポレーティッド | Nitrosated and nitrosylated diuretic compounds, compositions and methods of use |
US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
AU2006216665A1 (en) | 2005-02-24 | 2006-08-31 | Nicox S.A. | Nitric oxide enhancing diuretic compounds, compositions and methods of use |
DE102008061247A1 (en) | 2008-12-10 | 2010-06-24 | Christian-Albrechts-Universität Zu Kiel | Inhibitors of dimethylarginine dimethylaminohydrolase |
DK2615092T3 (en) * | 2010-09-10 | 2015-09-21 | Hangzhou Bensheng Pharmaceutical Co Ltd | Heterocyclic AMINOBERBAMIN DERIVATIVES, PREPARATION METHOD AND USE THEREOF |
CN110041291B (en) * | 2018-01-15 | 2021-02-26 | 北京采瑞医药科技研究院有限公司 | Macamide derivative and preparation method thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3313813A (en) * | 1962-10-30 | 1967-04-11 | Merck & Co Inc | (3-amino-5, 6-disubstituted-pyrazinoyl) guanidines |
US3527758A (en) * | 1967-04-13 | 1970-09-08 | Merck & Co Inc | Process for the preparation of pyrazinoylguanidines from a pyrazinoic azide and a guanidine |
US3539569A (en) * | 1968-08-21 | 1970-11-10 | Merck & Co Inc | Preparation of pyrazinoylguanidines from pyrazinoylureas |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7803906A (en) * | 1978-04-12 | 1979-10-16 | Noordvos Schroeven Bv | METHOD, DEVICE AND PROPELLER FOR DISTRIBUTING A GAS, POWDER OR LIQUID MATERIAL IN A LIQUID. |
-
1992
- 1992-07-28 TW TW081105973A patent/TW213903B/zh active
- 1992-07-31 DK DK92916697.3T patent/DK0598770T3/en active
- 1992-07-31 SK SK175-94A patent/SK17594A3/en unknown
- 1992-07-31 WO PCT/EP1992/001738 patent/WO1993004048A1/en active IP Right Grant
- 1992-07-31 AT AT92916697T patent/ATE159250T1/en not_active IP Right Cessation
- 1992-07-31 ES ES92916697T patent/ES2108129T3/en not_active Expired - Lifetime
- 1992-07-31 AU AU23870/92A patent/AU669122B2/en not_active Ceased
- 1992-07-31 RU RU94015265A patent/RU2124008C1/en active
- 1992-07-31 CZ CZ94337A patent/CZ280760B6/en unknown
- 1992-07-31 DE DE59208974T patent/DE59208974D1/en not_active Expired - Fee Related
- 1992-07-31 CA CA002115755A patent/CA2115755A1/en not_active Abandoned
- 1992-07-31 SG SG1996002613A patent/SG46307A1/en unknown
- 1992-07-31 EP EP92916697A patent/EP0598770B1/en not_active Expired - Lifetime
- 1992-07-31 JP JP5504057A patent/JPH06509798A/en active Pending
- 1992-07-31 HU HU9400430A patent/HUT67661A/en unknown
- 1992-08-11 MX MX9204637A patent/MX9204637A/en not_active IP Right Cessation
- 1992-08-14 IL IL102814A patent/IL102814A0/en unknown
- 1992-08-14 NZ NZ243959A patent/NZ243959A/en unknown
- 1992-08-17 IE IE259292A patent/IE922592A1/en not_active IP Right Cessation
-
1994
- 1994-02-15 FI FI940696A patent/FI940696A0/en unknown
- 1994-02-15 NO NO940523A patent/NO301542B1/en unknown
-
1997
- 1997-12-23 GR GR970403392T patent/GR3025742T3/en unknown
-
1998
- 1998-03-17 HK HK98102228A patent/HK1003137A1/en not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3313813A (en) * | 1962-10-30 | 1967-04-11 | Merck & Co Inc | (3-amino-5, 6-disubstituted-pyrazinoyl) guanidines |
US3527758A (en) * | 1967-04-13 | 1970-09-08 | Merck & Co Inc | Process for the preparation of pyrazinoylguanidines from a pyrazinoic azide and a guanidine |
US3539569A (en) * | 1968-08-21 | 1970-11-10 | Merck & Co Inc | Preparation of pyrazinoylguanidines from pyrazinoylureas |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6645969B1 (en) | 1991-05-10 | 2003-11-11 | Aventis Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase |
Also Published As
Publication number | Publication date |
---|---|
HUT67661A (en) | 1995-04-28 |
SK17594A3 (en) | 1994-12-07 |
NO940523D0 (en) | 1994-02-15 |
AU2387092A (en) | 1993-03-16 |
HU9400430D0 (en) | 1994-05-30 |
IE922592A1 (en) | 1993-02-24 |
EP0598770A1 (en) | 1994-06-01 |
GR3025742T3 (en) | 1998-03-31 |
CZ33794A3 (en) | 1994-07-13 |
RU2124008C1 (en) | 1998-12-27 |
TW213903B (en) | 1993-10-01 |
IL102814A0 (en) | 1993-01-31 |
MX9204637A (en) | 1993-02-01 |
JPH06509798A (en) | 1994-11-02 |
FI940696A (en) | 1994-02-15 |
CZ280760B6 (en) | 1996-04-17 |
CA2115755A1 (en) | 1993-03-04 |
FI940696A0 (en) | 1994-02-15 |
EP0598770B1 (en) | 1997-10-15 |
RU94015265A (en) | 1997-02-20 |
NO301542B1 (en) | 1997-11-10 |
DE59208974D1 (en) | 1997-11-20 |
ES2108129T3 (en) | 1997-12-16 |
SG46307A1 (en) | 1998-02-20 |
ATE159250T1 (en) | 1997-11-15 |
HK1003137A1 (en) | 1998-10-09 |
DK0598770T3 (en) | 1997-12-15 |
NO940523L (en) | 1994-02-15 |
NZ243959A (en) | 1995-07-26 |
WO1993004048A1 (en) | 1993-03-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |