JPS6434965A - Novel aconitine based compound and analgesic and antiphlogistic agent containing said compound as active ingredient - Google Patents
Novel aconitine based compound and analgesic and antiphlogistic agent containing said compound as active ingredientInfo
- Publication number
- JPS6434965A JPS6434965A JP29747387A JP29747387A JPS6434965A JP S6434965 A JPS6434965 A JP S6434965A JP 29747387 A JP29747387 A JP 29747387A JP 29747387 A JP29747387 A JP 29747387A JP S6434965 A JPS6434965 A JP S6434965A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- analgesic
- compound
- acetyl
- expressed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An aconitine based compound expressed by formula I (R1 is benzoyl or anisoyl; R2 is methyl or ethyl; R3 is acetyl when R1 is benzoyl and R3 is acetyl or H when R1 is anisole; R4 is higher fatty acid residue). EXAMPLE:3-Acetyl-8-O-linoleoyl-14-benzoylmesaconitine. USE:Analgesic and antiphlogistic agents having low toxicity and having actin different from morphine without making an effect on the analgesic action even in use with an antinarcotic through the analgesic action is weak compared with morphine. PREPARATION:Hydroxyl group at 3 position of mesaconitine expressed by formula II, aconitine expressed by formula III or dieconitine expressed by formula IV is acetylated and then acetyl group at 8 position is substituted with a higher fatty acid residue or acetyl group at 8 position of diecosaconitine is substituted with a higher fatty acid residue to provide the compound expressed by formula I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62297473A JPH085865B2 (en) | 1987-04-06 | 1987-11-27 | Novel aconitine compounds and analgesic / anti-inflammatory agents containing them as active ingredients |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62-83043 | 1987-04-06 | ||
JP8304387 | 1987-04-06 | ||
JP62297473A JPH085865B2 (en) | 1987-04-06 | 1987-11-27 | Novel aconitine compounds and analgesic / anti-inflammatory agents containing them as active ingredients |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6434965A true JPS6434965A (en) | 1989-02-06 |
JPH085865B2 JPH085865B2 (en) | 1996-01-24 |
Family
ID=26424111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP62297473A Expired - Lifetime JPH085865B2 (en) | 1987-04-06 | 1987-11-27 | Novel aconitine compounds and analgesic / anti-inflammatory agents containing them as active ingredients |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH085865B2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991013129A1 (en) * | 1990-03-02 | 1991-09-05 | Chevron Research And Technology Company | Method for controlling multistage reforming process to give high octane barrel per calendar day throughput |
WO1993001175A1 (en) * | 1991-07-08 | 1993-01-21 | Sanwa Shoyaku Kabushiki Kaisha | 14-O-p-CHLOROBENZOYLACONINE AND ANALGESIC/ANTIINFLAMMATORY AGENT |
WO1993006087A1 (en) * | 1991-09-27 | 1993-04-01 | Sanwa Shoyaku Kabushiki Kaisha | Novel aconitine compound and analgesic/antiinflammatory agent |
WO1995021827A1 (en) * | 1994-02-09 | 1995-08-17 | Sanwa Shoyaku Kabushiki Kaisha | Novel aconitine-like compound and antipyretic analgesic anti-inflammatory agent |
EP0739882B1 (en) * | 1991-09-27 | 2001-06-13 | Sanwa Shoyaku Kabushiki Kaisha | Novel aconitine compounds and analgesic/anti-inflammatory agent containing the same |
-
1987
- 1987-11-27 JP JP62297473A patent/JPH085865B2/en not_active Expired - Lifetime
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991013129A1 (en) * | 1990-03-02 | 1991-09-05 | Chevron Research And Technology Company | Method for controlling multistage reforming process to give high octane barrel per calendar day throughput |
WO1993001175A1 (en) * | 1991-07-08 | 1993-01-21 | Sanwa Shoyaku Kabushiki Kaisha | 14-O-p-CHLOROBENZOYLACONINE AND ANALGESIC/ANTIINFLAMMATORY AGENT |
US5330983A (en) * | 1991-07-08 | 1994-07-19 | Sanwa Shoyaku Kabushiki Kaisha | 14-O-p-chlorobenzoylaconine and analgesic/anti-inflammatory agent containing the same |
WO1993006087A1 (en) * | 1991-09-27 | 1993-04-01 | Sanwa Shoyaku Kabushiki Kaisha | Novel aconitine compound and analgesic/antiinflammatory agent |
EP0739882B1 (en) * | 1991-09-27 | 2001-06-13 | Sanwa Shoyaku Kabushiki Kaisha | Novel aconitine compounds and analgesic/anti-inflammatory agent containing the same |
WO1995021827A1 (en) * | 1994-02-09 | 1995-08-17 | Sanwa Shoyaku Kabushiki Kaisha | Novel aconitine-like compound and antipyretic analgesic anti-inflammatory agent |
Also Published As
Publication number | Publication date |
---|---|
JPH085865B2 (en) | 1996-01-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2041168A1 (en) | Use of alkylcarboxylic acid dimethylamides as crystallization inhibitors | |
NZ332608A (en) | alkyl 17-alpha-dichloroacetoxy-11- beta-hydroxy-androsta-1,4-diene-3-one-17-beta-carboxylates and medicaments | |
MY117090A (en) | Substituted benzamidines, their preparation and their use as pharmaceutical compounds | |
JPS6434965A (en) | Novel aconitine based compound and analgesic and antiphlogistic agent containing said compound as active ingredient | |
JPS5395958A (en) | Prostaglandin analogues and process for their preparation | |
EP0124252A3 (en) | Double ester of 16beta-ethylestran-17beta-ol derivatives | |
JPS5742643A (en) | 6,10,14,18-tetramethyl-5,9,13,17-nonadecatetraene-2-ol | |
JPS5566592A (en) | 7-alkoxythiazolo 3,2-a pyrimidine derivative, its preparation, and drug containing the same | |
JPS5295674A (en) | Preparation of 4#-substituted-2-methyl-2-piperidinopropiophenone and i ts salts | |
IE812843L (en) | Estra-4,9-dienes | |
JPS53119819A (en) | Substituted iso-valerianic acid and its ester | |
JPS5427578A (en) | 1-carboxyalkylcarbamoyl-5-fluorouracil derivatives and their preparation | |
JPS57165357A (en) | Novel optically active azidocarboxylic acid or ester thereof and its preparation | |
JPS545924A (en) | Derivative of butylaldeyde and its preparation | |
JPS5625166A (en) | 5-fluorouracil derivative | |
JPS5538301A (en) | New derivative of antibiotics fortimicin and its preparation | |
JPS537662A (en) | Preparation of injection containing stable dehydroepiandrosterone sulfate | |
JPS5283515A (en) | N-dimethyl-1- (l-(-)-alpha-hydroxy-omega-aminoalkanoyl) -xk-62-2 | |
ES8307712A1 (en) | A novel vasodilator compound, process for the preparation thereof and pharmaceutical compositions thereform. | |
JPS55162741A (en) | Preparation of formic acid ester of terpene alcohol | |
JPS52133917A (en) | Conjugated unsaturated carboxylic acid derivatives and preparation thereof | |
JPS5373566A (en) | 7,8,9,10,-tetrahydrophenanthridone-3-acetic acids | |
JPS55102548A (en) | Nitrosamine derivative | |
JPS52105120A (en) | N-acyl-alpha-acetoxyamino acid esters and their preparation | |
JPS5395938A (en) | 4-chloro-3,5-dinitrobenzoic acid alkyl ester derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EXPY | Cancellation because of completion of term |