JPS6434965A - Novel aconitine based compound and analgesic and antiphlogistic agent containing said compound as active ingredient - Google Patents

Novel aconitine based compound and analgesic and antiphlogistic agent containing said compound as active ingredient

Info

Publication number
JPS6434965A
JPS6434965A JP29747387A JP29747387A JPS6434965A JP S6434965 A JPS6434965 A JP S6434965A JP 29747387 A JP29747387 A JP 29747387A JP 29747387 A JP29747387 A JP 29747387A JP S6434965 A JPS6434965 A JP S6434965A
Authority
JP
Japan
Prior art keywords
formula
analgesic
compound
acetyl
expressed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP29747387A
Other languages
Japanese (ja)
Other versions
JPH085865B2 (en
Inventor
Mitsuo Murayama
Takao Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanwa Shoyaku Co Ltd
Original Assignee
Sanwa Shoyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanwa Shoyaku Co Ltd filed Critical Sanwa Shoyaku Co Ltd
Priority to JP62297473A priority Critical patent/JPH085865B2/en
Publication of JPS6434965A publication Critical patent/JPS6434965A/en
Publication of JPH085865B2 publication Critical patent/JPH085865B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An aconitine based compound expressed by formula I (R1 is benzoyl or anisoyl; R2 is methyl or ethyl; R3 is acetyl when R1 is benzoyl and R3 is acetyl or H when R1 is anisole; R4 is higher fatty acid residue). EXAMPLE:3-Acetyl-8-O-linoleoyl-14-benzoylmesaconitine. USE:Analgesic and antiphlogistic agents having low toxicity and having actin different from morphine without making an effect on the analgesic action even in use with an antinarcotic through the analgesic action is weak compared with morphine. PREPARATION:Hydroxyl group at 3 position of mesaconitine expressed by formula II, aconitine expressed by formula III or dieconitine expressed by formula IV is acetylated and then acetyl group at 8 position is substituted with a higher fatty acid residue or acetyl group at 8 position of diecosaconitine is substituted with a higher fatty acid residue to provide the compound expressed by formula I.
JP62297473A 1987-04-06 1987-11-27 Novel aconitine compounds and analgesic / anti-inflammatory agents containing them as active ingredients Expired - Lifetime JPH085865B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62297473A JPH085865B2 (en) 1987-04-06 1987-11-27 Novel aconitine compounds and analgesic / anti-inflammatory agents containing them as active ingredients

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP62-83043 1987-04-06
JP8304387 1987-04-06
JP62297473A JPH085865B2 (en) 1987-04-06 1987-11-27 Novel aconitine compounds and analgesic / anti-inflammatory agents containing them as active ingredients

Publications (2)

Publication Number Publication Date
JPS6434965A true JPS6434965A (en) 1989-02-06
JPH085865B2 JPH085865B2 (en) 1996-01-24

Family

ID=26424111

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62297473A Expired - Lifetime JPH085865B2 (en) 1987-04-06 1987-11-27 Novel aconitine compounds and analgesic / anti-inflammatory agents containing them as active ingredients

Country Status (1)

Country Link
JP (1) JPH085865B2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991013129A1 (en) * 1990-03-02 1991-09-05 Chevron Research And Technology Company Method for controlling multistage reforming process to give high octane barrel per calendar day throughput
WO1993001175A1 (en) * 1991-07-08 1993-01-21 Sanwa Shoyaku Kabushiki Kaisha 14-O-p-CHLOROBENZOYLACONINE AND ANALGESIC/ANTIINFLAMMATORY AGENT
WO1993006087A1 (en) * 1991-09-27 1993-04-01 Sanwa Shoyaku Kabushiki Kaisha Novel aconitine compound and analgesic/antiinflammatory agent
WO1995021827A1 (en) * 1994-02-09 1995-08-17 Sanwa Shoyaku Kabushiki Kaisha Novel aconitine-like compound and antipyretic analgesic anti-inflammatory agent
EP0739882B1 (en) * 1991-09-27 2001-06-13 Sanwa Shoyaku Kabushiki Kaisha Novel aconitine compounds and analgesic/anti-inflammatory agent containing the same

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991013129A1 (en) * 1990-03-02 1991-09-05 Chevron Research And Technology Company Method for controlling multistage reforming process to give high octane barrel per calendar day throughput
WO1993001175A1 (en) * 1991-07-08 1993-01-21 Sanwa Shoyaku Kabushiki Kaisha 14-O-p-CHLOROBENZOYLACONINE AND ANALGESIC/ANTIINFLAMMATORY AGENT
US5330983A (en) * 1991-07-08 1994-07-19 Sanwa Shoyaku Kabushiki Kaisha 14-O-p-chlorobenzoylaconine and analgesic/anti-inflammatory agent containing the same
WO1993006087A1 (en) * 1991-09-27 1993-04-01 Sanwa Shoyaku Kabushiki Kaisha Novel aconitine compound and analgesic/antiinflammatory agent
EP0739882B1 (en) * 1991-09-27 2001-06-13 Sanwa Shoyaku Kabushiki Kaisha Novel aconitine compounds and analgesic/anti-inflammatory agent containing the same
WO1995021827A1 (en) * 1994-02-09 1995-08-17 Sanwa Shoyaku Kabushiki Kaisha Novel aconitine-like compound and antipyretic analgesic anti-inflammatory agent

Also Published As

Publication number Publication date
JPH085865B2 (en) 1996-01-24

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Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term