DE69414085T2 - Wirkstoff zum schutze von gehirnzellen - Google Patents

Wirkstoff zum schutze von gehirnzellen

Info

Publication number
DE69414085T2
DE69414085T2 DE69414085T DE69414085T DE69414085T2 DE 69414085 T2 DE69414085 T2 DE 69414085T2 DE 69414085 T DE69414085 T DE 69414085T DE 69414085 T DE69414085 T DE 69414085T DE 69414085 T2 DE69414085 T2 DE 69414085T2
Authority
DE
Germany
Prior art keywords
active substance
brain cells
protect brain
protect
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69414085T
Other languages
English (en)
Other versions
DE69414085D1 (de
Inventor
Hiroshi Nagase
Yoshifumi Toray Indust Imamura
Takashi Endo
Susumu Toray Industrie Matsuda
Yasushi Toray Industr Miyauchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of DE69414085D1 publication Critical patent/DE69414085D1/de
Publication of DE69414085T2 publication Critical patent/DE69414085T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69414085T 1993-07-19 1994-07-19 Wirkstoff zum schutze von gehirnzellen Expired - Lifetime DE69414085T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17796393 1993-07-19
PCT/JP1994/001186 WO1995003307A1 (fr) 1993-07-19 1994-07-19 Agent de protection de cellules cerebrales

Publications (2)

Publication Number Publication Date
DE69414085D1 DE69414085D1 (de) 1998-11-26
DE69414085T2 true DE69414085T2 (de) 1999-03-18

Family

ID=16040143

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69414085T Expired - Lifetime DE69414085T2 (de) 1993-07-19 1994-07-19 Wirkstoff zum schutze von gehirnzellen

Country Status (8)

Country Link
US (2) US5972953A (de)
EP (1) EP0661283B1 (de)
JP (1) JP3948026B2 (de)
KR (1) KR100341950B1 (de)
CA (1) CA2144770C (de)
DE (1) DE69414085T2 (de)
TW (1) TW401400B (de)
WO (1) WO1995003307A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69414085T2 (de) * 1993-07-19 1999-03-18 Toray Industries Wirkstoff zum schutze von gehirnzellen
NZ268969A (en) * 1993-07-23 1997-06-24 Toray Industries Morphinan derivatives and pharmaceutical compositions
EP0829481A1 (de) * 1996-09-16 1998-03-18 Pfizer Inc. Morphinan-Hydroxamsäure-Derivate
WO1998031684A1 (fr) * 1997-01-16 1998-07-23 Toray Industries, Inc. Derives d'indolomorphinane et medicaments/remedes preventifs contre les troubles cerebraux
WO2001014383A1 (fr) * 1999-08-24 2001-03-01 Toray Industries, Inc. Remedes contre les douleurs neuropathiques et modeles animaux de douleurs neuropathiques
DE10161963A1 (de) * 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
CN1328280C (zh) * 2002-11-28 2007-07-25 中国科学院上海药物研究所 汉防己碱和汉防己碱化合物,合成和应用
CN101155814B (zh) 2005-04-06 2010-06-16 东丽株式会社 吗啡喃衍生物的晶体及其制备方法
EP1762569A1 (de) * 2005-09-12 2007-03-14 Alcasynn Pharmaceuticals Gmbh Neue 6-Amino-morphinanderivate, Herstellungsverfahren dafür und deren Verwendung als Analgetika
EP2151240B1 (de) 2007-04-24 2013-06-12 Toray Industries, Inc. Therapeutischer oder prophylaktischer wirkstoff gegen dyskinesie
PL2168580T3 (pl) 2007-06-22 2016-06-30 Toray Industries Środek do leczenia lub zapobiegania schizofrenii
WO2009044883A1 (ja) 2007-10-05 2009-04-09 Toray Industries, Inc. モルヒナン誘導体またはその薬理学的に許容される酸付加塩を有効成分とする皮膚性状改善治療薬
WO2010006299A1 (en) * 2008-07-11 2010-01-14 Regents Of The University Of Minnesota Analgesic agents
TWI477505B (zh) 2010-01-29 2015-03-21 Toray Industries 膽管疾病之治療或預防劑
US20130289060A1 (en) 2010-10-19 2013-10-31 Memorial Sloan-Kettering Cancer Center 6-AMIDO DERIVATIVES OF 4, 5-a EPOXYMORPHINANS FOR THE TREATMENT OF PAIN
CN103327977B (zh) 2011-01-31 2016-05-04 东丽株式会社 恶液质的治疗或预防剂
CN102701992B (zh) * 2012-07-03 2014-01-15 重庆医科大学 一种抗肿瘤化合物及其药学上可接受的盐、及制备方法和应用
EP3291676B1 (de) 2015-04-30 2022-08-17 Memorial Sloan Kettering Cancer Center Mitragynin-analoga und verwendungen davon
CN106866688B (zh) * 2015-12-10 2019-05-03 山东诚创医药技术开发有限公司 一种纳呋拉啡的精制方法
WO2017165558A1 (en) 2016-03-22 2017-09-28 Regents Of The University Of Minnesota Combination for treating pain
US11214577B2 (en) * 2019-03-29 2022-01-04 Humanwell Pharmaceutical US Morphinans useful for treating medical disorders
WO2023163969A2 (en) * 2022-02-22 2023-08-31 Virginia Commonwealth University Naltrexamine derivatives bearing 5-member heterocyclic ring systems as opioid receptor modulators
WO2024044179A1 (en) * 2022-08-23 2024-02-29 Virginia Commonwealth University Multiple targeting opioid receptor ligands as novel analgesics with minimum abuse liability

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE788478A (fr) * 1971-09-08 1973-03-06 Bristol Myers Co Procede de preparation de composes analgesiques
DE2807035A1 (de) * 1977-02-23 1978-08-24 Gen Electric Glasplatte
GB1587831A (en) * 1977-03-23 1981-04-08 Reckitt & Colmann Prod Ltd Morphine derivatives
US4267182A (en) * 1979-01-16 1981-05-12 The United States Of America As Represented By The Secretary Of The Army Narcotic antagonists in the therapy of shock
US4362870A (en) * 1980-01-16 1982-12-07 Regents Of The University Of Minnesota Selective opioid receptor alkylating agents
DE3029475A1 (de) * 1980-08-02 1982-03-25 Hoechst Ag, 6000 Frankfurt Transferdrucktraeger, verfahren zu seiner herstellung und seine verwendung
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
US4767718A (en) * 1984-06-18 1988-08-30 Southern Illinois University Foundation Fluorescent opioid reagents and methods of use thereof in the detection of opioid receptors
HU196376B (en) * 1985-05-23 1988-11-28 Sandoz Ag Process for preparing morphinane derivatives and pharmaceutical compositions containing such compounds
US4806556A (en) * 1985-12-12 1989-02-21 Regents Of The University Of Minnesota Gut-selective opiates
US4673679A (en) * 1986-05-14 1987-06-16 E. I. Du Pont De Nemours And Company Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
GB8711558D0 (en) * 1987-05-15 1987-06-17 Reckitt & Colmann Prod Ltd Derivative of codeine
US4906637A (en) * 1987-06-05 1990-03-06 Faden Alan I Traumatic and ischemic brain injury treatment with opiate-receptor antagonists
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
US5219861A (en) * 1988-12-21 1993-06-15 Chugai Seiyaku Kabushiki Kaisha 6 β-Thiomorphine derivatives
JPH04118826A (ja) * 1990-09-06 1992-04-20 Mitsubishi Denki Shomei Kk タッチスイッチ
ATE172201T1 (de) * 1992-01-23 1998-10-15 Toray Industries Morphinan-derivate und medizinische verwendung
US5852030A (en) * 1992-09-29 1998-12-22 Toray Industries, Inc. Indole derivatives, process for producing the same and medicinal uses of the same
US5321012A (en) * 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
CN1111900A (zh) * 1993-06-30 1995-11-15 东丽株式会社 止咳药
DE69414085T2 (de) * 1993-07-19 1999-03-18 Toray Industries Wirkstoff zum schutze von gehirnzellen
NZ268969A (en) * 1993-07-23 1997-06-24 Toray Industries Morphinan derivatives and pharmaceutical compositions
FR2740973B1 (fr) * 1995-11-15 1998-02-06 Lipha Nouvelle forme d'administration de l'hydroxocobalamine et son utilisation dans les intoxications par les cyanures
EP0829481A1 (de) * 1996-09-16 1998-03-18 Pfizer Inc. Morphinan-Hydroxamsäure-Derivate

Also Published As

Publication number Publication date
EP0661283A1 (de) 1995-07-05
US5972953A (en) 1999-10-26
CA2144770C (en) 2006-02-28
TW401400B (en) 2000-08-11
CA2144770A1 (en) 1995-02-02
EP0661283B1 (de) 1998-10-21
KR950703564A (ko) 1995-09-20
WO1995003307A1 (fr) 1995-02-02
KR100341950B1 (ko) 2002-11-29
JP3948026B2 (ja) 2007-07-25
DE69414085D1 (de) 1998-11-26
US6147084A (en) 2000-11-14
EP0661283A4 (de) 1995-12-20

Similar Documents

Publication Publication Date Title
DE69414085T2 (de) Wirkstoff zum schutze von gehirnzellen
DE69332648D1 (de) Grossflächige aktive Matrix
DE69331492D1 (de) Batteriesatz
DE69331801D1 (de) Batteriepack
DE59309561D1 (de) Defibrillierungselektrode
DE69329456D1 (de) Reservoir zum umschliessen und nehmen von körperproben
DE59308003D1 (de) Defibrillierungselektrode
BR8603359A (pt) Processo para produzir sementes de milho macho-estereis genicas;sementes de milho macho-estereis e processo para produzir milho hibrido
DK304888D0 (da) Indpakning til batterier
DK277090A (da) Batteripakning
DE69319789D1 (de) Elektrodenanordnung
KR900700449A (ko) 세포 분화의 유발에 유효한 화합물
DE69333945D1 (de) Flache Elektrode
DE69330893T2 (de) Zelle
DE69302341T2 (de) Lithiumzelle
DK70989A (da) Elektrode
DE69530070D1 (de) Verbesserte zelle zur überwachung von photochemischen reaktionen
DK159670C (da) Aktivt panser
DE69422296D1 (de) Insektenfalle zum schutz von vieh
FI896091A0 (fi) Korkeatoimiset polarisaattorit
DE3361724D1 (en) Optically active n-substituted phenylalaninols and use therefor
DE68927496T2 (de) Iontophorese Elektrode
DK268390D0 (da) Elektrode
DE69313417D1 (de) Batterie-Pack
DE69330392T2 (de) Cytarabine Ocfosfate enthaltende harte Kapsel

Legal Events

Date Code Title Description
8364 No opposition during term of opposition