FR2735127B1 - Nouvelles piperazines heteroaromatiques utiles comme medicaments. - Google Patents

Nouvelles piperazines heteroaromatiques utiles comme medicaments.

Info

Publication number
FR2735127B1
FR2735127B1 FR9506825A FR9506825A FR2735127B1 FR 2735127 B1 FR2735127 B1 FR 2735127B1 FR 9506825 A FR9506825 A FR 9506825A FR 9506825 A FR9506825 A FR 9506825A FR 2735127 B1 FR2735127 B1 FR 2735127B1
Authority
FR
France
Prior art keywords
medicaments
piperazines useful
new heteroaromatic
heteroaromatic
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9506825A
Other languages
English (en)
Other versions
FR2735127A1 (fr
Inventor
Serge Halazy
Marie Lamothe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to FR9506825A priority Critical patent/FR2735127B1/fr
Priority to PCT/FR1996/000853 priority patent/WO1996041802A1/fr
Priority to AU62296/96A priority patent/AU6229696A/en
Publication of FR2735127A1 publication Critical patent/FR2735127A1/fr
Application granted granted Critical
Publication of FR2735127B1 publication Critical patent/FR2735127B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
FR9506825A 1995-06-09 1995-06-09 Nouvelles piperazines heteroaromatiques utiles comme medicaments. Expired - Fee Related FR2735127B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR9506825A FR2735127B1 (fr) 1995-06-09 1995-06-09 Nouvelles piperazines heteroaromatiques utiles comme medicaments.
PCT/FR1996/000853 WO1996041802A1 (fr) 1995-06-09 1996-06-06 Nouvelles piperazines heteroaromatiques utiles comme medicaments
AU62296/96A AU6229696A (en) 1995-06-09 1996-06-06 Novel heteroaromatic piperazines for use as drugs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9506825A FR2735127B1 (fr) 1995-06-09 1995-06-09 Nouvelles piperazines heteroaromatiques utiles comme medicaments.

Publications (2)

Publication Number Publication Date
FR2735127A1 FR2735127A1 (fr) 1996-12-13
FR2735127B1 true FR2735127B1 (fr) 1997-08-22

Family

ID=9479790

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9506825A Expired - Fee Related FR2735127B1 (fr) 1995-06-09 1995-06-09 Nouvelles piperazines heteroaromatiques utiles comme medicaments.

Country Status (3)

Country Link
AU (1) AU6229696A (fr)
FR (1) FR2735127B1 (fr)
WO (1) WO1996041802A1 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2761068B1 (fr) * 1997-03-20 1999-04-23 Synthelabo Derives de piperazin-4-ylthieno[3,2-c]pyridin-4-yl-2- carboxamide, leur preparation et leur application en therapeutique
KR20050010018A (ko) * 2002-05-31 2005-01-26 다케다 야쿠힌 고교 가부시키가이샤 피페리딘 유도체, 이의 제조 방법 및 용도
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
CA2668959A1 (fr) 2006-11-09 2008-05-15 F. Hoffmann-La Roche Ag Derives d'indole et de benzofuran 2-carboxamide
EP2102157B1 (fr) 2006-12-19 2011-06-22 F. Hoffmann-La Roche AG Dérivés hétéroarylés de pyrrolidinyl et pipéridinyl cétones
CN102985557B (zh) 2009-03-13 2018-06-15 安吉奥斯医药品有限公司 用于细胞增殖相关病症的方法和组合物
EP2417123A2 (fr) 2009-04-06 2012-02-15 Agios Pharmaceuticals, Inc. Compositions thérapeutiques et procédés d'utilisation associés
EP2448582B1 (fr) 2009-06-29 2017-04-19 Agios Pharmaceuticals, Inc. Dérivés de quinoline-8-sulfonamide ayant une activité anticancéreuse
ES2618630T3 (es) 2009-06-29 2017-06-21 Agios Pharmaceuticals, Inc. Composiciones terapéuticas y métodos de uso relacionados
ES2594402T3 (es) 2009-10-21 2016-12-20 Agios Pharmaceuticals, Inc. Métodos y composiciones para trastornos relacionados con la proliferación celular
EP2525790B1 (fr) 2009-10-21 2020-05-27 Agios Pharmaceuticals, Inc. Procédés et compositions pour troubles associés à la prolifération cellulaire
JP5967827B2 (ja) * 2009-12-09 2016-08-10 アジオス ファーマシューティカルズ， インコーポレイテッド Ｉｄｈ変異体をもつことを特徴とする癌治療用の治療的活性化合物
MX2013006900A (es) 2010-12-17 2013-10-17 Agios Pharmaceuticals Inc Nuevos derivados n-(4-(azetidina-1-carbonil)fenil)-(hetero-)arilsu lfonamida como moduladores piruvato quinasa m2 (pmk2).
CA2822432C (fr) 2010-12-21 2019-09-24 Agios Pharmaceuticals, Inc. Activateurs bicycliques de pkm2
TWI549947B (zh) 2010-12-29 2016-09-21 阿吉歐斯製藥公司 治療化合物及組成物
HUE039269T2 (hu) 2011-05-03 2018-12-28 Agios Pharmaceuticals Inc Piruvát-kináz aktivátorok terápiában történõ alkalmazásra
CN102827170A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
CN102827073A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
NZ627096A (en) 2012-01-06 2017-02-24 Agios Pharmaceuticals Inc Triazinyl compounds and their methods of use
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
CN104822373B (zh) 2012-10-15 2018-08-28 安吉奥斯医药品有限公司 治疗性化合物和组合物
WO2015003355A2 (fr) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Composés thérapeutiquement actifs et leurs méthodes d'utilisation
EP3019480B1 (fr) 2013-07-11 2020-05-06 Agios Pharmaceuticals, Inc. Composés 2,4- ou 4,6-diaminopyrimidine comme inhibiteurs d'idh2 mutantes pour le traitement du cancer
WO2015003360A2 (fr) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Composés thérapeutiquement actifs et leurs méthodes d'utilisation
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
US20150031627A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
AU2015229214B2 (en) 2014-03-14 2019-07-11 Les Laboratoires Servier Pharmaceutical compositions of therapeutically active compounds
US11234976B2 (en) 2015-06-11 2022-02-01 Agios Pharmaceuticals, Inc. Methods of using pyruvate kinase activators
SI3362066T1 (sl) 2015-10-15 2022-04-29 Les Laboratoires Servier Kombinirana terapija za zdravljenje malignosti
KR20180061372A (ko) 2015-10-15 2018-06-07 아지오스 파마슈티컬스 아이엔씨. 악성 종양의 치료를 위한 조합물 요법
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436246A (en) * 1992-09-17 1995-07-25 Merrell Dow Pharmaceuticals Inc. Serotonin receptor agents
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
GB9300195D0 (en) * 1993-01-06 1993-03-03 Wyeth John & Brother Ltd Piperazine derivatives

Also Published As

Publication number Publication date
WO1996041802A1 (fr) 1996-12-27
AU6229696A (en) 1997-01-09
FR2735127A1 (fr) 1996-12-13

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Legal Events

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ST Notification of lapse
ST Notification of lapse