MXPA04007775A - Derivados de sulfonilo como novedosos inhibidores de la histona desacetilasa. - Google Patents
Derivados de sulfonilo como novedosos inhibidores de la histona desacetilasa.Info
- Publication number
- MXPA04007775A MXPA04007775A MXPA04007775A MXPA04007775A MXPA04007775A MX PA04007775 A MXPA04007775 A MX PA04007775A MX PA04007775 A MXPA04007775 A MX PA04007775A MX PA04007775 A MXPA04007775 A MX PA04007775A MX PA04007775 A MXPA04007775 A MX PA04007775A
- Authority
- MX
- Mexico
- Prior art keywords
- histone deacetylase
- sulfonyl
- derivatives
- novel inhibitors
- novel
- Prior art date
Links
- 102000003964 Histone deacetylase Human genes 0.000 title abstract 2
- 108090000353 Histone deacetylase Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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Abstract
Esta invencion comprende los novedosos compuestos de formula (I)(Ver formula I)en donde n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z y (Ver formula) tienen significados definidos, teniendo actividad enzimatica inhibidora de la histona desacetilasa; su preparacion, composiciones que los contienen y su utilizacion como una medicina.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US36379902P | 2002-03-13 | 2002-03-13 | |
US42098902P | 2002-10-24 | 2002-10-24 | |
PCT/EP2003/002516 WO2003076422A1 (en) | 2002-03-13 | 2003-03-11 | Sulfonyl-derivatives as novel inhibitors of histone deacetylase |
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Publication Number | Publication Date |
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MXPA04007775A true MXPA04007775A (es) | 2004-10-15 |
Family
ID=27807998
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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MXPA04007775A MXPA04007775A (es) | 2002-03-13 | 2003-03-11 | Derivados de sulfonilo como novedosos inhibidores de la histona desacetilasa. |
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US (6) | US7205304B2 (es) |
EP (1) | EP1485365B1 (es) |
JP (1) | JP4725946B2 (es) |
KR (1) | KR20040090978A (es) |
CN (2) | CN101450934B (es) |
AR (1) | AR039568A1 (es) |
AT (1) | ATE395343T1 (es) |
AU (1) | AU2003218738B2 (es) |
BR (1) | BR0307575A (es) |
CA (1) | CA2476586C (es) |
DE (1) | DE60320957D1 (es) |
DK (1) | DK1485365T3 (es) |
EA (1) | EA006707B1 (es) |
ES (1) | ES2306859T3 (es) |
HR (1) | HRP20040802A2 (es) |
IL (2) | IL164002A0 (es) |
MX (1) | MXPA04007775A (es) |
NO (1) | NO20044314L (es) |
NZ (1) | NZ534830A (es) |
OA (1) | OA12792A (es) |
PL (1) | PL220783B1 (es) |
TW (1) | TW200400941A (es) |
WO (1) | WO2003076422A1 (es) |
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