DK2274301T3 - Azabicyclohexylsubstituerede indolylalkylaminoderivater som hidtil ukendte inhibitorer af histondeacetylase - Google Patents
Azabicyclohexylsubstituerede indolylalkylaminoderivater som hidtil ukendte inhibitorer af histondeacetylaseInfo
- Publication number
- DK2274301T3 DK2274301T3 DK09725004.7T DK09725004T DK2274301T3 DK 2274301 T3 DK2274301 T3 DK 2274301T3 DK 09725004 T DK09725004 T DK 09725004T DK 2274301 T3 DK2274301 T3 DK 2274301T3
- Authority
- DK
- Denmark
- Prior art keywords
- indolylalkylaminode
- histondeacetylase
- azabicyclohexyl
- derivatives
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08153370 | 2008-03-27 | ||
| PCT/EP2009/053566 WO2009118370A1 (en) | 2008-03-27 | 2009-03-26 | Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2274301T3 true DK2274301T3 (da) | 2013-01-02 |
Family
ID=39767068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09725004.7T DK2274301T3 (da) | 2008-03-27 | 2009-03-26 | Azabicyclohexylsubstituerede indolylalkylaminoderivater som hidtil ukendte inhibitorer af histondeacetylase |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8476289B2 (da) |
| EP (1) | EP2274301B1 (da) |
| JP (1) | JP5564033B2 (da) |
| AU (1) | AU2009228931B2 (da) |
| CA (1) | CA2716932C (da) |
| DK (1) | DK2274301T3 (da) |
| ES (1) | ES2395347T3 (da) |
| WO (1) | WO2009118370A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE033114T2 (en) | 2011-11-18 | 2017-11-28 | Heptares Therapeutics Ltd | Muscarin M1 receptor agonists |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| EP2970177A1 (en) | 2013-03-15 | 2016-01-20 | Pfizer Inc. | Indole compounds that activate ampk |
| GB201513743D0 (en) | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonists |
| GB201617454D0 (en) | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
| GB201709652D0 (en) | 2017-06-16 | 2017-08-02 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201810239D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201819960D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB202020191D0 (en) | 2020-12-18 | 2021-02-03 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0827742A1 (en) | 1996-09-04 | 1998-03-11 | Vrije Universiteit Brussel | Use of histone deacetylase inhibitors for treating fribosis or cirrhosis |
| AU2003215112A1 (en) * | 2002-02-07 | 2003-09-02 | Axys Pharmaceuticals | Novel bicyclic hydroxamates as inhibitors of histone deacetylase |
| CN1305850C (zh) | 2002-03-13 | 2007-03-21 | 詹森药业有限公司 | 作为组蛋白脱乙酰酶新颖抑制剂的磺酰基氨基衍生物 |
| BR0308081A (pt) | 2002-03-13 | 2004-12-21 | Janssen Pharmaceutica Nv | Inibidores de histona desacetilase |
| EA007270B1 (ru) | 2002-03-13 | 2006-08-25 | Янссен Фармацевтика Н.В. | Пиперазинил-, пиперидинил- и морфолинилпроизводные как новые ингибиторы гистондеацетилазы |
| WO2003076395A1 (en) | 2002-03-13 | 2003-09-18 | Janssen Pharmaceutica N.V. | Carbonylamino-derivatives as novel inhibitors of histone deacetylase |
| EP1485378B1 (en) | 2002-03-13 | 2008-06-18 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
| CN101450934B (zh) | 2002-03-13 | 2012-10-10 | 詹森药业有限公司 | 用作组蛋白去乙酰酶抑制剂的磺酰基衍生物 |
| ES2309313T3 (es) | 2002-04-03 | 2008-12-16 | Topotarget Uk Limited | Compuestos del acido carbamico que comprenden un acoplamiento de piperacina como hdac inhibidores. |
| TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| DE10233412A1 (de) | 2002-07-23 | 2004-02-12 | 4Sc Ag | Neue Verbindungen als Histondeacetylase-Inhibitoren |
| JP2005539001A (ja) | 2002-08-02 | 2005-12-22 | アージェンタ・ディスカバリー・リミテッド | ヒストンデアセチラーゼインヒビターとしての置換チエニルヒドロキサム酸 |
| EP1546326A4 (en) | 2002-09-26 | 2008-04-30 | Genentech Inc | NEW COMPOSITIONS AND METHODS FOR THE TREATMENT OF PSORIASIS |
| ITMI20030025A1 (it) | 2003-01-10 | 2004-07-11 | Italfarmaco Spa | Derivati dell'acido idrossammico ad attivita' antinfiammatoria. |
| US7135493B2 (en) | 2003-01-13 | 2006-11-14 | Astellas Pharma Inc. | HDAC inhibitor |
| AU2003900608A0 (en) | 2003-02-11 | 2003-02-27 | Fujisawa Pharmaceutical Co., Ltd. | Hdac inhibitor |
| US7375228B2 (en) | 2003-03-17 | 2008-05-20 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| DE602004021573D1 (de) | 2003-04-07 | 2009-07-30 | Pharmacyclics Inc | Hydroxamate als therapeutische mittel |
| EP1663953A1 (en) | 2003-09-24 | 2006-06-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| EP1685094A4 (en) | 2003-10-27 | 2007-08-22 | S Bio Pte Ltd | HYDROXAMATES CONNECTED TO ACYLUREE AND SULFONYLUREE |
| US20070167499A1 (en) | 2003-10-27 | 2007-07-19 | A*Bio Pte Ltd. | Biaryl linked hydroxamates: preparation and pharmaceutical applications |
| EP1735319B1 (en) | 2004-03-26 | 2017-05-03 | MethylGene Inc. | Inhibitors of histone deacetylase |
| US7345043B2 (en) | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
| WO2006010750A1 (en) * | 2004-07-28 | 2006-02-02 | Janssen Pharmaceutica N.V. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
| GB0510204D0 (en) * | 2005-05-19 | 2005-06-22 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| GB0521244D0 (en) | 2005-10-19 | 2005-11-30 | Astrazeneca Ab | Benzamide compounds |
| AU2006312084A1 (en) | 2005-11-03 | 2007-05-18 | Merck Sharp & Dohme Corp. | Substituted nicotinamide compounds |
| CA2633100C (en) | 2006-01-19 | 2014-12-09 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| CA2631876C (en) | 2006-01-19 | 2014-05-27 | Janssen Pharmaceutica N.V. | Aminophenyl derivatives as inhibitors of histone deacetylase |
| JP5137849B2 (ja) | 2006-01-19 | 2013-02-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼのインヒビターとしての置換インドリル−アルキル−アミノ−誘導体 |
| US7750155B2 (en) | 2006-02-07 | 2010-07-06 | Astellas Pharma Inc. | Pyrazinyl hydroxyacrylamide compounds having an inhibitory effect on the activity of histone deacetylase |
| JP2009528354A (ja) | 2006-02-28 | 2009-08-06 | メルク エンド カムパニー インコーポレーテッド | ヒストン脱アセチル化酵素のインヒビター |
| AU2008319308B2 (en) * | 2007-10-31 | 2013-01-31 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
-
2009
- 2009-03-26 JP JP2011501229A patent/JP5564033B2/ja active Active
- 2009-03-26 ES ES09725004T patent/ES2395347T3/es active Active
- 2009-03-26 WO PCT/EP2009/053566 patent/WO2009118370A1/en active Application Filing
- 2009-03-26 EP EP09725004A patent/EP2274301B1/en active Active
- 2009-03-26 US US12/934,894 patent/US8476289B2/en active Active
- 2009-03-26 CA CA2716932A patent/CA2716932C/en active Active
- 2009-03-26 DK DK09725004.7T patent/DK2274301T3/da active
- 2009-03-26 AU AU2009228931A patent/AU2009228931B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009118370A1 (en) | 2009-10-01 |
| AU2009228931B2 (en) | 2013-05-23 |
| US8476289B2 (en) | 2013-07-02 |
| ES2395347T3 (es) | 2013-02-12 |
| US20110015218A1 (en) | 2011-01-20 |
| AU2009228931A1 (en) | 2009-10-01 |
| EP2274301A1 (en) | 2011-01-19 |
| CA2716932A1 (en) | 2009-10-01 |
| CA2716932C (en) | 2017-07-04 |
| EP2274301B1 (en) | 2012-09-26 |
| JP5564033B2 (ja) | 2014-07-30 |
| JP2011515448A (ja) | 2011-05-19 |
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