DK2300465T3 - Imidazopyridinderivater som hæmmere af receptortyrosinkinaser - Google Patents

Imidazopyridinderivater som hæmmere af receptortyrosinkinaser Download PDF

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Publication number
DK2300465T3
DK2300465T3 DK09761801.1T DK09761801T DK2300465T3 DK 2300465 T3 DK2300465 T3 DK 2300465T3 DK 09761801 T DK09761801 T DK 09761801T DK 2300465 T3 DK2300465 T3 DK 2300465T3
Authority
DK
Denmark
Prior art keywords
receptoryrosinkinases
imidazopyridin
derivatives
understanding
Prior art date
Application number
DK09761801.1T
Other languages
English (en)
Inventor
Valerio Berdini
Maria Grazia Carr
Miles Stuart Congreve
Martyn Frederickson
Charlotte Mary Griffiths-Jones
Christopher Charles Frederick Hamlett
Christopher William Murray
Rajdeep Kaur Benning
Gordon Saxty
Emma Vickerstaffe
Andrew James Woodhead
Eddy Jean Edgard Freyne
Tom Cornelis Hortense Govaerts
Patrick René Angibaud
Andrew Madin
Steven John Woodhead
Brian John Williams
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US6118408P priority Critical
Priority to GBGB0810902.7A priority patent/GB0810902D0/en
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Priority to PCT/EP2009/057318 priority patent/WO2009150240A1/en
Application granted granted Critical
Publication of DK2300465T3 publication Critical patent/DK2300465T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
DK09761801.1T 2008-06-13 2009-06-12 Imidazopyridinderivater som hæmmere af receptortyrosinkinaser DK2300465T3 (da)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US6118408P true 2008-06-13 2008-06-13
GBGB0810902.7A GB0810902D0 (en) 2008-06-13 2008-06-13 New compounds
PCT/EP2009/057318 WO2009150240A1 (en) 2008-06-13 2009-06-12 Imidazopyridine derivatives as inhibitors of receptor tyrosine kinases

Publications (1)

Publication Number Publication Date
DK2300465T3 true DK2300465T3 (da) 2019-06-24

Family

ID=39672279

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09761801.1T DK2300465T3 (da) 2008-06-13 2009-06-12 Imidazopyridinderivater som hæmmere af receptortyrosinkinaser

Country Status (21)

Country Link
US (1) US8796244B2 (da)
EP (1) EP2300465B1 (da)
JP (1) JP5596023B2 (da)
KR (1) KR101745730B1 (da)
CN (1) CN102137859B (da)
AU (1) AU2009256584B2 (da)
BR (1) BRPI0915084B1 (da)
CA (1) CA2727062A1 (da)
DK (1) DK2300465T3 (da)
ES (1) ES2735979T3 (da)
GB (1) GB0810902D0 (da)
HR (1) HRP20191027T1 (da)
HU (1) HUE045300T2 (da)
IL (1) IL209864A (da)
LT (1) LT2300465T (da)
MX (1) MX2010013743A (da)
NZ (1) NZ589781A (da)
RU (1) RU2518089C2 (da)
SI (1) SI2300465T1 (da)
WO (1) WO2009150240A1 (da)
ZA (1) ZA201008961B (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009006704A (es) 2006-12-22 2009-06-30 Astex Therapeutics Ltd TRICICLIC AMINE DERIVATIVES AS INHIBITORS OF PROTEIN OF THYROSINE KINASE.
JP5442448B2 (ja) 2006-12-22 2014-03-12 アステックス、セラピューティックス、リミテッドAstex Therapeutics Limited Bicyclic heterocyclic compounds as FGFR inhibitors
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
GB0810902D0 (en) 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
JP2012521354A (ja) * 2009-03-20 2012-09-13 アムジエン・インコーポレーテツド Pi3キナーゼの阻害薬
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
GB0906470D0 (en) * 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
WO2011104731A1 (en) * 2010-02-26 2011-09-01 Decode Genetics Ehf Genetic variants as markers for use in urinary bladder cancer risk assessment, diagnosis, prognosis and treatment
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
WO2013018733A1 (ja) 2011-07-29 2013-02-07 富士フイルム株式会社 1,5-ナフチリジン誘導体又はその塩
MX344025B (es) 2011-10-10 2016-12-01 Orion Corp QUINASE PROTEIN INHIBITORS.
CN103214481B (zh) * 2012-01-21 2016-08-03 中国科学院上海药物研究所 新型咪唑并[1,2-a]吡啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途
SG11201408238WA (en) 2012-06-13 2015-01-29 Incyte Corp Substituted tricyclic compounds as fgfr inhibitors
CN102786543B (zh) * 2012-07-24 2016-04-27 上海瑞博化学有限公司 咪唑并[1,2-a]吡啶-6-硼酸频哪醇酯及其衍生物的制备方法
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US8729263B2 (en) 2012-08-13 2014-05-20 Novartis Ag 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
CA2886187C (en) * 2012-09-28 2020-04-14 Vanderbilt University Fused heterocyclic compounds as selective bmp inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
CN104918922B (zh) 2012-12-20 2017-04-26 因森普深2公司 三唑酮化合物及其用途
CN103923078A (zh) * 2013-01-15 2014-07-16 华东理工大学 3,4-二取代(1H-吡唑[3,4-b]吡啶)类化合物及其用途
AR094812A1 (es) 2013-02-20 2015-08-26 Eisai R&D Man Co Ltd DERIVED FROM MONOCYCLIC PYRIDINE AS AN FGFR INHIBITOR
CA2948763C (en) 2013-03-13 2018-04-24 F. Hoffmann-La Roche Ag Process for making benzoxazepin compounds
BR112015026307A2 (pt) 2013-04-19 2017-10-10 Incyte Corp bicyclic heterocycles as fgfr inhibitors
US9556126B2 (en) 2013-12-20 2017-01-31 Signal Pharmaceuticals, Llc Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith
CA2956270A1 (en) 2014-08-18 2016-02-25 Eisai R&D Management Co., Ltd. Salt of monocyclic pyridine derivative and crystal thereof
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
EP3259269B9 (en) 2015-02-20 2020-07-29 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
SG11201706495RA (en) 2015-02-20 2017-09-28 Incyte Corp Bicyclic heterocycles as fgfr4 inhibitors
WO2016152996A1 (ja) * 2015-03-24 2016-09-29 株式会社ダイセル 超臨界流体クロマトグラフィー用の固定相
EP3277704A1 (en) 2015-03-31 2018-02-07 Allergan, Inc. Cyclosporins modified on the mebmt sidechain by heterocyclic rings
CN109952293A (zh) * 2016-09-14 2019-06-28 范德比尔特大学 Bmp信号转导的抑制、化合物、组合物及其用途
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
US10745400B2 (en) 2018-03-14 2020-08-18 Vanderbuilt University Inhibition of BMP signaling, compounds, compositions and uses thereof

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202B1 (da) 1985-03-28 1990-11-27 Cetus Corp
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5554630A (en) 1993-03-24 1996-09-10 Neurosearch A/S Benzimidazole compounds
CA2191979A1 (en) 1994-06-20 1995-12-28 Muneo Takatani Condensed imidazole compounds, their production and use
WO1996034866A1 (en) 1995-05-01 1996-11-07 Fujisawa Pharmaceutical Co., Ltd. Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivatives and their use as bone resorption inhibitors
CA2744096C (en) 1996-07-31 2013-07-30 Laboratory Corporation Of America Holdings Biomarkers and targets for diagnosis, prognosis and management of prostate disease
US6218529B1 (en) 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
WO1997012613A1 (en) 1995-10-05 1997-04-10 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
TW414795B (en) * 1996-07-01 2000-12-11 Yamanouchi Pharma Co Ltd A thiophene derivative and the pharmaceutical composition
PT915880E (pt) 1996-07-24 2007-12-31 Bristol Myers Squibb Pharma Co AZOLE TRIAZINES AND PYRIMIDINES
PT1344779E (pt) 1998-01-28 2005-10-31 Squibb Bristol Myers Co Azolo-pirimidinas
JP2002501532A (ja) 1997-05-30 2002-01-15 メルク エンド カンパニー インコーポレーテッド 新規血管形成阻害薬
US5990146A (en) 1997-08-20 1999-11-23 Warner-Lambert Company Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation
US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
JP2002523459A (ja) 1998-08-31 2002-07-30 メルク エンド カムパニー インコーポレーテッド 新規血管形成阻害剤
US6245759B1 (en) 1999-03-11 2001-06-12 Merck & Co., Inc. Tyrosine kinase inhibitors
EP1206260A4 (en) 1999-06-30 2002-10-30 Merck & Co Inc Src kinase inhibitor compounds
WO2001000214A1 (en) 1999-06-30 2001-01-04 Merck & Co., Inc. Src kinase inhibitor compounds
AU5636900A (en) 1999-06-30 2001-01-31 Merck & Co., Inc. Src kinase inhibitor compounds
JP2001057292A (ja) 1999-08-20 2001-02-27 Toray Ind Inc 発光素子
GB9919778D0 (en) 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
GB9921150D0 (en) 1999-09-07 1999-11-10 Merck Sharp & Dohme Therapeutic agents
EP1214330A1 (en) 1999-09-21 2002-06-19 LION Bioscience AG Benzimidazole derivatives and combinatorial libraries thereof
GB9927687D0 (en) 1999-11-23 2000-01-19 Merck Sharp & Dohme Therapeutic agents
JP2003525291A (ja) 2000-03-01 2003-08-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 2,4−二置換チアゾリル誘導体
WO2001066098A2 (en) 2000-03-09 2001-09-13 Aventis Pharma Deutschland Gmbh Therapeutic uses of ppar mediators
US20020041880A1 (en) 2000-07-05 2002-04-11 Defeo-Jones Deborah Method of treating cancer
JP2004519422A (ja) 2000-08-04 2004-07-02 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニーWarner−Lambert Companyllc 2−(4−ピリジル)アミノ−6−ジアルコキシフェニルピリド〔2,3−d〕ピリミジン−7−オン
AU9599201A (en) 2000-10-24 2002-05-06 Sankyo Co Imidazopyridine derivatives
GB0027561D0 (en) 2000-11-10 2000-12-27 Merck Sharp & Dohme Therapeutic agents
AU2123902A (en) 2000-12-07 2002-06-18 Astrazeneca Ab Therapeutic benzimidazole compounds
US20020107262A1 (en) 2000-12-08 2002-08-08 3M Innovative Properties Company Substituted imidazopyridines
GB0103926D0 (en) 2001-02-17 2001-04-04 Astrazeneca Ab Chemical compounds
SE0100568D0 (sv) 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
IL156784D0 (en) 2001-02-20 2004-02-08 Astrazeneca Ab 2-arylamino-pyrimidines for the treatment of gsk3-related disorders
SE0100567D0 (sv) 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
TWI248936B (en) 2001-03-21 2006-02-11 Merck Sharp & Dohme Imidazo-pyrimidine derivatives as ligands for GABA receptors
DE10117183A1 (de) 2001-04-05 2002-10-10 Gruenenthal Gmbh Use of substituted imidazo [1,2-a] pyridine compounds as medicaments
EP1382603B1 (en) 2001-04-26 2008-07-23 Eisai R&D Management Co., Ltd. Nitrogenous fused-ring compound having pyrazolyl group as substituent and medicinal composition thereof
AU2002317377A1 (en) 2001-07-20 2003-03-03 Cancer Research Technology Limited Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer
GB0128499D0 (en) 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
US6900208B2 (en) 2002-03-28 2005-05-31 Bristol Myers Squibb Company Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
CN100343255C (zh) 2002-04-23 2007-10-17 盐野义制药株式会社 吡唑并[1,5-a]嘧啶衍生物和含有该衍生物的NAD(P)H氧化酶抑制剂
JP2004002826A (ja) 2002-04-24 2004-01-08 Sankyo Co Ltd 高分子イミダゾピリジン誘導体
US7125888B2 (en) 2002-05-02 2006-10-24 Merck & Co., Inc. Tyrosine kinase inhibitors
US7259179B2 (en) 2002-05-23 2007-08-21 Cytopia Research Pty Ltd Kinase inhibitors
GB0212049D0 (en) 2002-05-24 2002-07-03 Merck Sharp & Dohme Therapeutic agents
MXPA04012245A (es) 2002-06-04 2005-09-30 Neogenesis Pharmaceuticals Inc PIRAZOLO COMPOUNDS [1,5A] PYRIMIDINE AS ANTIVIRAL AGENTS.
US7196090B2 (en) 2002-07-25 2007-03-27 Warner-Lambert Company Kinase inhibitors
JP4845379B2 (ja) 2002-09-19 2011-12-28 シェーリング コーポレイションSchering Corporation サイクリン依存性キナーゼインヒビターとしてのイミダゾピリジン
GB0223349D0 (en) 2002-10-08 2002-11-13 Merck Sharp & Dohme Therapeutic agents
WO2004035579A1 (ja) 2002-10-15 2004-04-29 Takeda Pharmaceutical Company Limited イミダゾピリジン誘導体、その製造法および用途
AU2003298942A1 (en) 2002-12-11 2004-06-30 Merck And Co., Inc. Tyrosine kinase inhibitors
WO2004052315A2 (en) 2002-12-11 2004-06-24 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2004075021A2 (en) 2003-02-14 2004-09-02 Vertex Pharmaceuticals, Inc. Molecular modeling methods
US7476670B2 (en) 2003-02-18 2009-01-13 Aventis Pharma S.A. Purine derivatives, method for preparing, pharmaceutical compositions and novel use
US7157460B2 (en) 2003-02-20 2007-01-02 Sugen Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
WO2004087153A2 (en) 2003-03-28 2004-10-14 Chiron Corporation Use of organic compounds for immunopotentiation
DE602004020073D1 (de) 2003-08-21 2009-04-30 Osi Pharm Inc 3-SUBSTITUTED IMIDAZOPYRIDINE DERIVATIVES AS C-KIT INHIBITORS
AP200603549A0 (en) 2003-08-21 2006-04-30 Osi Pharm Inc N-substituted benzimidazolyl C-kit inhibitors.
US7442709B2 (en) 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
ES2578254T3 (es) 2003-12-03 2016-07-22 Ym Biosciences Australia Pty Ltd Azol-based kinase inhibitors
JP2007519720A (ja) 2004-01-28 2007-07-19 スミスクライン ビーチャム コーポレーション チアゾール化合物
TW200530236A (en) 2004-02-23 2005-09-16 Chugai Pharmaceutical Co Ltd Heteroaryl phenylurea
US7566781B2 (en) 2004-05-10 2009-07-28 Banyu Pharmaceutical Co., Ltd. Imidazopyridine compound
JP4972804B2 (ja) 2004-08-31 2012-07-11 Msd株式会社 新規置換イミダゾール誘導体
WO2006034402A2 (en) 2004-09-21 2006-03-30 Synta Pharmaceutical Corp. Compounds for inflammation and immune-related uses
WO2006038001A1 (en) 2004-10-06 2006-04-13 Celltech R & D Limited Aminopyrimidine derivatives as jnk inhibitors
AR052419A1 (es) 2004-12-01 2007-03-21 Osi Pharm Inc Derivados de bencimidazolil n-sustituidos,inhibidores del protooncogen c-kit
JPWO2006070943A1 (ja) 2004-12-28 2008-06-12 武田薬品工業株式会社 縮合イミダゾール化合物およびその用途
US20100160324A1 (en) 2004-12-30 2010-06-24 Astex Therapeutics Limited Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases
DOP2006000051A (es) 2005-02-24 2006-08-31 Lilly Co Eli Inhibidores de vegf-r2 y métodos
EP1853590A1 (en) 2005-03-03 2007-11-14 Sirtris Pharmaceuticals, Inc. Fused heterocyclic compounds and their use as sirtuin modulators
AU2006232105A1 (en) 2005-04-05 2006-10-12 Pharmacopeia, Inc. Purine and imidazopyridine derivatives for immunosuppression
FR2884821B1 (fr) * 2005-04-26 2007-07-06 Aventis Pharma Sa Pyrrolopyridines substitues, compositions les contenant, procede de fabrication et utilisation
US7572807B2 (en) 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
JP2009512636A (ja) 2005-09-30 2009-03-26 アストラゼネカ アクチボラグ 細胞増殖抑制作用を有するイミダゾ[1,2−a]ピリジン類
CA2645434A1 (en) 2006-03-20 2007-09-27 Synta Pharmaceutical Corp. Benzoimidazolyl-parazine compounds for inflammation and immune-related uses
AU2007230911A1 (en) 2006-03-23 2007-10-04 Synta Pharmaceuticals Corp. Benzimidazolyl-pyridine compounds for inflammation and immune-related uses
ITVA20060041A1 (it) 2006-07-05 2008-01-06 Dialectica Srl Uso di composti derivati amminotiazolici, di loro composizioni farmaceutiche, nel trattamento di malattie caratterizzate dalla anormale repressione della trascrizione genica, particolarmente il morbo di huntington
TW200811134A (en) 2006-07-12 2008-03-01 Irm Llc Compounds and compositions as protein kinase inhibitors
EP1882475A1 (en) 2006-07-26 2008-01-30 Novartis AG Method of treating disorders mediated by the fibroblast growth factor receptor
US7737149B2 (en) 2006-12-21 2010-06-15 Astrazeneca Ab N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
JP5442448B2 (ja) * 2006-12-22 2014-03-12 アステックス、セラピューティックス、リミテッドAstex Therapeutics Limited Bicyclic heterocyclic compounds as FGFR inhibitors
US8131527B1 (en) 2006-12-22 2012-03-06 Astex Therapeutics Ltd. FGFR pharmacophore compounds
MX2009006704A (es) 2006-12-22 2009-06-30 Astex Therapeutics Ltd TRICICLIC AMINE DERIVATIVES AS INHIBITORS OF PROTEIN OF THYROSINE KINASE.
GB0625826D0 (en) * 2006-12-22 2007-02-07 Astex Therapeutics Ltd New compounds
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
RS52862B (en) 2007-04-03 2013-12-31 Array Biopharma Inc. Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors
CA2691987C (en) 2007-06-12 2016-08-16 Achaogen, Inc. Antibacterial agents
CA2690192A1 (en) 2007-06-26 2008-12-31 Gilead Colorado, Inc. Imidazopyridinyl thiazolyl histone deacetylase inhibitors
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
GB0810902D0 (en) 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds

Also Published As

Publication number Publication date
KR101745730B1 (ko) 2017-06-12
ES2735979T3 (es) 2019-12-23
BRPI0915084B1 (pt) 2020-02-11
HUE045300T2 (hu) 2019-12-30
IL209864A (en) 2015-10-29
CA2727062A1 (en) 2009-12-17
BRPI0915084A2 (pt) 2015-10-27
KR20110017000A (ko) 2011-02-18
HRP20191027T1 (hr) 2019-11-29
ZA201008961B (en) 2015-05-27
GB0810902D0 (en) 2008-07-23
RU2518089C2 (ru) 2014-06-10
EP2300465B1 (en) 2019-04-17
AU2009256584A1 (en) 2009-12-17
US20120208791A1 (en) 2012-08-16
RU2011100786A (ru) 2012-07-20
NZ589781A (en) 2013-02-22
LT2300465T (lt) 2019-06-25
EP2300465A1 (en) 2011-03-30
IL209864D0 (en) 2011-02-28
JP2011522866A (ja) 2011-08-04
JP5596023B2 (ja) 2014-09-24
AU2009256584B2 (en) 2014-06-12
SI2300465T1 (sl) 2019-08-30
WO2009150240A1 (en) 2009-12-17
CN102137859A (zh) 2011-07-27
CN102137859B (zh) 2015-07-01
MX2010013743A (es) 2011-02-15
US8796244B2 (en) 2014-08-05

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