EP1685094A4 - Acylurea connected and sulfonylurea connected hydroxamates - Google Patents
Acylurea connected and sulfonylurea connected hydroxamatesInfo
- Publication number
- EP1685094A4 EP1685094A4 EP04775672A EP04775672A EP1685094A4 EP 1685094 A4 EP1685094 A4 EP 1685094A4 EP 04775672 A EP04775672 A EP 04775672A EP 04775672 A EP04775672 A EP 04775672A EP 1685094 A4 EP1685094 A4 EP 1685094A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- sulfonylurea
- acylurea
- hydroxamates
- connected hydroxamates
- acylurea connected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51401303P | 2003-10-27 | 2003-10-27 | |
PCT/SG2004/000353 WO2005040101A1 (en) | 2003-10-27 | 2004-10-26 | Acylurea connected and sulfonylurea connected hydroxamates |
Publications (2)
Publication Number | Publication Date |
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EP1685094A1 EP1685094A1 (en) | 2006-08-02 |
EP1685094A4 true EP1685094A4 (en) | 2007-08-22 |
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Application Number | Title | Priority Date | Filing Date |
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EP04775672A Withdrawn EP1685094A4 (en) | 2003-10-27 | 2004-10-26 | Acylurea connected and sulfonylurea connected hydroxamates |
Country Status (8)
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EP (1) | EP1685094A4 (en) |
JP (1) | JP2007509930A (en) |
AR (1) | AR046920A1 (en) |
AU (1) | AU2004284030A1 (en) |
CA (1) | CA2543570A1 (en) |
MX (1) | MXPA06004735A (en) |
TW (1) | TW200530166A (en) |
WO (1) | WO2005040101A1 (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04008796A (en) | 2002-03-13 | 2004-11-26 | Janssen Pharmaceutica Nv | Carbonylamino-derivatives as novel inhibitors of histone deacetylase. |
ES2306880T3 (en) | 2002-03-13 | 2008-11-16 | Janssen Pharmaceutica Nv | DERIVATIVES OF SULFONYLAMINE AS NEW INHIBITORS OF HISTONE DEACETILASE. |
KR20040093692A (en) | 2002-03-13 | 2004-11-08 | 얀센 파마슈티카 엔.브이. | Piperazinyl-, piperidynyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
ATE473005T1 (en) | 2002-03-13 | 2010-07-15 | Janssen Pharmaceutica Nv | HISTONE DEACETYLASE INHIBITORS |
US20050137234A1 (en) * | 2003-12-19 | 2005-06-23 | Syrrx, Inc. | Histone deacetylase inhibitors |
EA010652B1 (en) | 2004-07-28 | 2008-10-30 | Янссен Фармацевтика Н.В. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
ME01058B (en) | 2004-07-28 | 2012-10-20 | Janssen Pharmaceutica Nv | Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase |
ITMI20041869A1 (en) | 2004-10-01 | 2005-01-01 | Dac Srl | NEW INHIBITORS OF DEACETYLASE HISTONS |
US8242175B2 (en) | 2004-10-01 | 2012-08-14 | Dac S.R.L. | Class of histone deacetylase inhibitors |
ITMI20060621A1 (en) * | 2006-03-31 | 2007-10-01 | Dac Srl | NEW CLASS OF INHIBITORS OF DEACETILASE HISTONS |
ITFI20050041A1 (en) * | 2005-03-15 | 2006-09-16 | Menarini Internat Operations Luxembourg Sa | HYDROXAMMED AS INHIBITORS OF ISTONE DEACELITASIS, THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS THAT CONTAIN THEM |
CN101163471A (en) | 2005-04-20 | 2008-04-16 | 默克公司 | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions |
AU2006248938B2 (en) | 2005-05-18 | 2011-09-29 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
WO2007011626A2 (en) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
CA2623360C (en) | 2005-10-27 | 2014-04-22 | Janssen Pharmaceutica N.V. | Squaric acid derivatives as inhibitors of histone deacetylase |
DK1979326T3 (en) | 2006-01-19 | 2013-01-07 | Janssen Pharmaceutica Nv | PYRIDINE AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF HISTONDEACETYLASE |
EP1979327A1 (en) | 2006-01-19 | 2008-10-15 | Janssen Pharmaceutica, N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
US7834025B2 (en) | 2006-01-19 | 2010-11-16 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
AU2007206946B2 (en) | 2006-01-19 | 2011-12-15 | Janssen Pharmaceutica N.V. | Aminophenyl derivatives as novel inhibitors of histone deacetylase |
AU2007206948B2 (en) | 2006-01-19 | 2012-08-23 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
ATE539073T1 (en) | 2006-01-19 | 2012-01-15 | Janssen Pharmaceutica Nv | HETEROCYCLYLALKYL DERIVATIVES AS NEW INHIBITORS OF HISTONE DEACETYLASE |
KR20100016171A (en) * | 2007-05-04 | 2010-02-12 | 노파르티스 아게 | Use of hdac inhibitors for the treatment of gastrointestinal cancers |
CN101417967A (en) * | 2007-10-26 | 2009-04-29 | 浙江海正药业股份有限公司 | Histone deacetylase inhibitor, compounds thereof and use thereof |
US8476289B2 (en) | 2008-03-27 | 2013-07-02 | Janssen Pharmaceutica Nv | Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylace |
WO2011009059A2 (en) * | 2009-07-17 | 2011-01-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of treating or preventing cancer |
WO2013041407A1 (en) * | 2011-09-19 | 2013-03-28 | Cellzome Ag | Hydroxamic acids as hdac6 inhibitors |
US9409858B2 (en) | 2012-03-07 | 2016-08-09 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Selective histone deactylase 6 inhibitors |
WO2013134467A1 (en) * | 2012-03-07 | 2013-09-12 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Selective histone deactylase 6 inhibitors |
AU2014260605B2 (en) * | 2013-04-29 | 2016-07-14 | Chong Kun Dang Pharmaceutical Corp. | Novel compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same |
US9751832B2 (en) | 2013-07-30 | 2017-09-05 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Selective histone deactylase 6 inhibitors |
WO2015058106A1 (en) * | 2013-10-18 | 2015-04-23 | The General Hospital Corporation | Imaging histone deacetylases with a radiotracer using positron emission tomography |
WO2015137750A1 (en) * | 2014-03-12 | 2015-09-17 | Chong Kun Dang Pharmaceutical Corp. | Novel compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions comprising the same |
CN113288888B (en) * | 2021-05-28 | 2023-02-03 | 烟台邦杰生物科技有限公司 | Compounds with vasodilating activity |
WO2023020412A1 (en) * | 2021-08-16 | 2023-02-23 | 中国科学院上海药物研究所 | Sulfonylurea compound, preparation method therefor, and application thereof |
Family Cites Families (1)
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JP2004143053A (en) * | 2002-10-22 | 2004-05-20 | Senju Pharmaceut Co Ltd | beta-AMINOHYDROXAMIC ACID DERIVATIVE AND USE THEREOF |
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2004
- 2004-10-26 EP EP04775672A patent/EP1685094A4/en not_active Withdrawn
- 2004-10-26 AR ARP040103893A patent/AR046920A1/en unknown
- 2004-10-26 AU AU2004284030A patent/AU2004284030A1/en not_active Abandoned
- 2004-10-26 MX MXPA06004735A patent/MXPA06004735A/en not_active Application Discontinuation
- 2004-10-26 JP JP2006537946A patent/JP2007509930A/en active Pending
- 2004-10-26 WO PCT/SG2004/000353 patent/WO2005040101A1/en active Application Filing
- 2004-10-26 CA CA002543570A patent/CA2543570A1/en not_active Abandoned
- 2004-10-26 TW TW093132561A patent/TW200530166A/en unknown
Non-Patent Citations (7)
Also Published As
Publication number | Publication date |
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AU2004284030A1 (en) | 2005-05-06 |
MXPA06004735A (en) | 2006-12-14 |
CA2543570A1 (en) | 2005-05-06 |
JP2007509930A (en) | 2007-04-19 |
AR046920A1 (en) | 2006-01-04 |
EP1685094A1 (en) | 2006-08-02 |
TW200530166A (en) | 2005-09-16 |
WO2005040101A1 (en) | 2005-05-06 |
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