EP1685094A4 - Mit acylharnstoff verbundene und mit sulfonylharnstoff verbundene hydroxamate - Google Patents
Mit acylharnstoff verbundene und mit sulfonylharnstoff verbundene hydroxamateInfo
- Publication number
- EP1685094A4 EP1685094A4 EP04775672A EP04775672A EP1685094A4 EP 1685094 A4 EP1685094 A4 EP 1685094A4 EP 04775672 A EP04775672 A EP 04775672A EP 04775672 A EP04775672 A EP 04775672A EP 1685094 A4 EP1685094 A4 EP 1685094A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- sulfonylurea
- acylurea
- hydroxamates
- connected hydroxamates
- acylurea connected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51401303P | 2003-10-27 | 2003-10-27 | |
PCT/SG2004/000353 WO2005040101A1 (en) | 2003-10-27 | 2004-10-26 | Acylurea connected and sulfonylurea connected hydroxamates |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1685094A1 EP1685094A1 (de) | 2006-08-02 |
EP1685094A4 true EP1685094A4 (de) | 2007-08-22 |
Family
ID=34520162
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04775672A Withdrawn EP1685094A4 (de) | 2003-10-27 | 2004-10-26 | Mit acylharnstoff verbundene und mit sulfonylharnstoff verbundene hydroxamate |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1685094A4 (de) |
JP (1) | JP2007509930A (de) |
AR (1) | AR046920A1 (de) |
AU (1) | AU2004284030A1 (de) |
CA (1) | CA2543570A1 (de) |
MX (1) | MXPA06004735A (de) |
TW (1) | TW200530166A (de) |
WO (1) | WO2005040101A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003212335B8 (en) | 2002-03-13 | 2009-04-23 | Janssen Pharmaceutica N.V. | Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase |
BR0307606A (pt) | 2002-03-13 | 2004-12-21 | Janssen Pharmaceutica Nv | Derivados de piperazinila, piperidinila e morfolinila como inibidores de histona desacetilase |
NZ534831A (en) | 2002-03-13 | 2007-01-26 | Janssen Pharmaceutica Nv | Carbonylamino-derivatives having histone deacetylase (HDAC) inhibiting enzymatic activity |
DK1485354T3 (da) | 2002-03-13 | 2008-09-01 | Janssen Pharmaceutica Nv | Sulfonylamino-derivater som nye inhibitorer af histandeacetylase |
WO2005066151A2 (en) * | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
WO2006010750A1 (en) | 2004-07-28 | 2006-02-02 | Janssen Pharmaceutica N.V. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
RS51189B (sr) | 2004-07-28 | 2010-10-31 | Janssen Pharmaceutica N.V. | Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze |
ITMI20041869A1 (it) | 2004-10-01 | 2005-01-01 | Dac Srl | Nuovi inibitori delle istone deacetilasi |
US8242175B2 (en) | 2004-10-01 | 2012-08-14 | Dac S.R.L. | Class of histone deacetylase inhibitors |
ITMI20060621A1 (it) * | 2006-03-31 | 2007-10-01 | Dac Srl | Nuova classe di inibitori delle istone deacetilasi |
ITFI20050041A1 (it) * | 2005-03-15 | 2006-09-16 | Menarini Internat Operations Luxembourg Sa | Idrossammati come inibitori dell'istone deacelitasi, loro preparazione e formulazioni farmaceutiche che li contengono |
JP2008536924A (ja) * | 2005-04-20 | 2008-09-11 | メルク エンド カムパニー インコーポレーテッド | ベンゾチオフェンヒドロキサミン酸のカーバメート、ウレア、アミドおよびスルホンアミド置換誘導体 |
EP1885710B1 (de) | 2005-05-18 | 2015-08-19 | Janssen Pharmaceutica N.V. | Substituierte aminopropenylpiperidin- oder morpholinderivate als neue histondeacetylase-hemmer |
CN101263121A (zh) | 2005-07-14 | 2008-09-10 | 塔克达圣地亚哥公司 | 组蛋白脱乙酰基酶抑制剂 |
EP1943232B1 (de) | 2005-10-27 | 2011-05-18 | Janssen Pharmaceutica NV | Quadratsäurederivate als Inhibitoren von Histondeacetylase |
JP5137849B2 (ja) | 2006-01-19 | 2013-02-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼのインヒビターとしての置換インドリル−アルキル−アミノ−誘導体 |
US7834011B2 (en) | 2006-01-19 | 2010-11-16 | Janssen Pharmaceutica N.V. | Heterocyclylalkyl derivatives as novel inhibitors of histone deacetylase |
AU2007206942B2 (en) | 2006-01-19 | 2012-08-23 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
AU2007206948B2 (en) | 2006-01-19 | 2012-08-23 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
AU2007206944B2 (en) | 2006-01-19 | 2012-08-23 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
SI1981874T1 (sl) | 2006-01-19 | 2009-10-31 | Janssen Pharmaceutica Nv | Aminofenilni derivati kot novi inhibitorji histon deacetilaze |
BRPI0811112A2 (pt) * | 2007-05-04 | 2014-12-23 | Novartis Ag | Uso de inibidores de hdac para o tratamento de cânceres gastrointestinais. |
CN101417967A (zh) * | 2007-10-26 | 2009-04-29 | 浙江海正药业股份有限公司 | 组蛋白去乙酰酶抑制剂、其组合物及其应用 |
CA2716932C (en) | 2008-03-27 | 2017-07-04 | Eddy Jean Edgard Freyne | Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
WO2011009059A2 (en) * | 2009-07-17 | 2011-01-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of treating or preventing cancer |
WO2013041407A1 (en) * | 2011-09-19 | 2013-03-28 | Cellzome Ag | Hydroxamic acids as hdac6 inhibitors |
WO2013134467A1 (en) * | 2012-03-07 | 2013-09-12 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Selective histone deactylase 6 inhibitors |
US9409858B2 (en) | 2012-03-07 | 2016-08-09 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Selective histone deactylase 6 inhibitors |
US9878986B2 (en) * | 2013-04-29 | 2018-01-30 | Chong Kun Dang Pharmaceutical Corp. | Compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same |
US9751832B2 (en) | 2013-07-30 | 2017-09-05 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Selective histone deactylase 6 inhibitors |
EP3062783B1 (de) * | 2013-10-18 | 2020-08-12 | The General Hospital Corporation | Bildgebung von histondeacetylasen mit einem radiotracer mittels positronenemissionstomografie |
EP3116859B1 (de) * | 2014-03-12 | 2018-08-01 | Chong Kun Dang Pharmaceutical Corp. | Neuartige verbindungen als histondeacetylase-6-inhibitoren und pharmazeutische zusammensetzungen damit |
CN113288888B (zh) * | 2021-05-28 | 2023-02-03 | 烟台邦杰生物科技有限公司 | 具有血管舒张活性的化合物 |
WO2023020412A1 (zh) * | 2021-08-16 | 2023-02-23 | 中国科学院上海药物研究所 | 磺酰脲化合物、制备方法及其应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2004143053A (ja) * | 2002-10-22 | 2004-05-20 | Senju Pharmaceut Co Ltd | β−アミノヒドロキサム酸誘導体およびその用途 |
-
2004
- 2004-10-26 TW TW093132561A patent/TW200530166A/zh unknown
- 2004-10-26 JP JP2006537946A patent/JP2007509930A/ja active Pending
- 2004-10-26 AR ARP040103893A patent/AR046920A1/es unknown
- 2004-10-26 CA CA002543570A patent/CA2543570A1/en not_active Abandoned
- 2004-10-26 WO PCT/SG2004/000353 patent/WO2005040101A1/en active Application Filing
- 2004-10-26 AU AU2004284030A patent/AU2004284030A1/en not_active Abandoned
- 2004-10-26 EP EP04775672A patent/EP1685094A4/de not_active Withdrawn
- 2004-10-26 MX MXPA06004735A patent/MXPA06004735A/es not_active Application Discontinuation
Non-Patent Citations (7)
Also Published As
Publication number | Publication date |
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TW200530166A (en) | 2005-09-16 |
AU2004284030A1 (en) | 2005-05-06 |
CA2543570A1 (en) | 2005-05-06 |
AR046920A1 (es) | 2006-01-04 |
MXPA06004735A (es) | 2006-12-14 |
EP1685094A1 (de) | 2006-08-02 |
WO2005040101A1 (en) | 2005-05-06 |
JP2007509930A (ja) | 2007-04-19 |
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