ATE537830T1 - Nicotinamid derivate und ihre verwendung als therapeutika - Google Patents

Nicotinamid derivate und ihre verwendung als therapeutika

Info

Publication number
ATE537830T1
ATE537830T1 AT04756752T AT04756752T ATE537830T1 AT E537830 T1 ATE537830 T1 AT E537830T1 AT 04756752 T AT04756752 T AT 04756752T AT 04756752 T AT04756752 T AT 04756752T AT E537830 T1 ATE537830 T1 AT E537830T1
Authority
AT
Austria
Prior art keywords
therapeutics
nicotinamide derivatives
mammal
formula
disclosed
Prior art date
Application number
AT04756752T
Other languages
English (en)
Inventor
Jian-Min Fu
Vishnumurthy Kodumuru
Shaoyi Sun
Michael Winther
Richard Fine
Daniel Harvey
Boris Klebansky
Mark Gray-Keller
Heinz Gschwend
Wenbao Li
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE537830T1 publication Critical patent/ATE537830T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT04756752T 2004-07-06 2004-07-06 Nicotinamid derivate und ihre verwendung als therapeutika ATE537830T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2004/021792 WO2006014168A1 (en) 2004-07-06 2004-07-06 Nicotinamide derivatives and their use as therapeutic agents

Publications (1)

Publication Number Publication Date
ATE537830T1 true ATE537830T1 (de) 2012-01-15

Family

ID=34958141

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04756752T ATE537830T1 (de) 2004-07-06 2004-07-06 Nicotinamid derivate und ihre verwendung als therapeutika

Country Status (10)

Country Link
EP (1) EP1763350B1 (de)
JP (1) JP2008505891A (de)
CN (1) CN1997371A (de)
AT (1) ATE537830T1 (de)
AU (1) AU2004321997A1 (de)
BR (1) BRPI0418939A (de)
CA (1) CA2573198A1 (de)
ES (1) ES2380020T3 (de)
MX (1) MX2007000028A (de)
WO (1) WO2006014168A1 (de)

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AU2005286648A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
US7919496B2 (en) 2004-09-20 2011-04-05 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
TW200626155A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
US7592343B2 (en) 2004-09-20 2009-09-22 Xenon Pharmaceuticals Inc. Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors
US7777036B2 (en) 2004-09-20 2010-08-17 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as therapeutic agents
AR051091A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
AR052319A1 (es) 2004-10-29 2007-03-14 Kalypsys Inc Compuestos biciclicos sustituidos por sulfonilo en funcion de moduladores del ppar
WO2007044085A2 (en) * 2005-05-19 2007-04-19 Xenon Pharmaceuticals Inc. Heteroaryl compounds and their uses as therapeutic agents
WO2007130075A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
CN101331122B (zh) 2005-10-25 2011-09-07 凯利普西斯公司 Ppar调节剂的盐和治疗代谢性疾病的方法
PE20080714A1 (es) 2006-06-05 2008-07-31 Novartis Ag DERIVADOS HETEROCICLICOS COMO MODULADORES DE LA ACTIVIDAD DE LA ESTEARIL-CoA-DESATURASA
CN101506203B (zh) 2006-08-24 2013-10-16 诺瓦提斯公司 治疗代谢病、心血管病和其他病症的作为硬脂酰辅酶a脱饱和酶(scd)抑制剂的2-(吡嗪-2-基)-噻唑和2-(1h-吡唑-3-基)-噻唑衍生物及相关化合物
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
WO2008157844A1 (en) 2007-06-21 2008-12-24 Forest Laboratories Holdings Limited Novel piperazine derivatives as inhibitors of stearoyl-coa desaturase
BRPI0814758A2 (pt) * 2007-08-03 2015-03-03 Hoffmann La Roche Piridinacarboxamida e derivados de benzamida como ligantes taar1
TWI432422B (zh) 2007-08-22 2014-04-01 Astrazeneca Ab 環丙基醯胺衍生物
CN101784528A (zh) * 2007-08-23 2010-07-21 塞诺菲-安万特股份有限公司 阿唑络林衍生物、其制备方法、包含这些化合物的药物和其用途
CN101597278B (zh) 2008-06-04 2013-04-17 中国中化股份有限公司 酰胺类化合物及其制备与应用
WO2010094120A1 (en) 2009-02-17 2010-08-26 Merck Frosst Canada Ltd. Novel spiro compounds useful as inhibitors of stearoyl-coenzyme a delta-9 desaturase
TW201039825A (en) 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
EP2459568A4 (de) 2009-07-28 2013-02-27 Merck Frosst Canada Ltd Neue spiroverbindungen als hemmer der stearoyl-coenzym-a-delta-9-desaturase
EP2475367A1 (de) 2009-09-10 2012-07-18 Centre National De La Recherche Scientifique Neuartige stearoyl-coa-desaturase-1-hemmer und ihre verwendung
AU2011218492B2 (en) 2010-02-18 2014-11-13 Astrazeneca Ab New crystalline form of a cyclopropyl benzamide derivative
WO2011147765A1 (de) * 2010-05-27 2011-12-01 Bayer Cropscience Ag Pyridinylcarbonsäure derivate als fungizide
KR101271538B1 (ko) 2011-06-24 2013-06-05 (주)이뮤노텍 유기산, ｌ―카르니틴, ｌ―아르기닌 및 니코틴아미드를 유효성분으로 포함하는 비만의 예방 및 개선용 조성물
KR20140084164A (ko) 2011-10-15 2014-07-04 제넨테크, 인크. 암의 치료를 위한 scd1 길항제
KR20150013777A (ko) 2012-05-22 2015-02-05 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘, 엘티디. 미분화세포의 선택적 억제제
JP2019533022A (ja) 2016-10-24 2019-11-14 ユマニティ セラピューティクス，インコーポレーテッド 化合物及びその使用
JP2020514293A (ja) 2017-01-06 2020-05-21 ユマニティ セラピューティクス，インコーポレーテッド 神経障害を治療する方法
CA3083000A1 (en) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Compounds and uses thereof
JP7517992B2 (ja) 2018-03-23 2024-07-17 ヤンセン ファーマシューティカ エヌ．ベー． 化合物及びその使用
CN113906019A (zh) 2019-01-24 2022-01-07 优曼尼蒂治疗公司 化合物及其用途
EA202192047A1 (ru) 2019-11-13 2021-12-08 Юманити Терапьютикс, Инк. Соединения и их применение

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WO2000044743A1 (en) * 1999-01-28 2000-08-03 Nippon Shinyaku Co., Ltd. Amide derivatives and drug compositions
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US7196080B2 (en) * 2001-06-15 2007-03-27 Astellas Pharma Inc. Phenylpyridinecarbonylpiperazinederivative
JPWO2003037862A1 (ja) * 2001-10-30 2005-02-17 日本新薬株式会社 アミド誘導体及び医薬
US6620811B2 (en) * 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
AU2002350172A1 (en) * 2001-12-07 2003-06-23 Eli Lilly And Company Substituted heterocyclic carboxamides with antithrombotic activity
PT1466912E (pt) * 2002-01-18 2013-06-28 Astellas Pharma Inc Derivado de 2-aciloaminotiazol ou seu sal
WO2003076422A1 (en) * 2002-03-13 2003-09-18 Janssen Pharmaceutica N.V. Sulfonyl-derivatives as novel inhibitors of histone deacetylase
CA2493584A1 (en) * 2002-07-25 2004-02-05 Wisconsin Alumni Research Foundation Inhibition of stearoyl-coa desaturase 1 (scd1) increases insulin sensitivity and treats diabetes

Also Published As

Publication number Publication date
WO2006014168A1 (en) 2006-02-09
ES2380020T3 (es) 2012-05-07
EP1763350A1 (de) 2007-03-21
JP2008505891A (ja) 2008-02-28
AU2004321997A1 (en) 2006-02-09
CA2573198A1 (en) 2006-02-09
EP1763350B1 (de) 2011-12-21
CN1997371A (zh) 2007-07-11
BRPI0418939A (pt) 2008-04-08
MX2007000028A (es) 2007-07-20

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