CU20090070A7 - Nuevos derivados de sulfonamida como antagonistas de la bradiquinina - Google Patents

Nuevos derivados de sulfonamida como antagonistas de la bradiquinina

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Publication number
CU20090070A7
CU20090070A7 CU20090070A CU20090070A CU20090070A7 CU 20090070 A7 CU20090070 A7 CU 20090070A7 CU 20090070 A CU20090070 A CU 20090070A CU 20090070 A CU20090070 A CU 20090070A CU 20090070 A7 CU20090070 A7 CU 20090070A7
Authority
CU
Cuba
Prior art keywords
antagonists
bradiquinina
sulfonamide
new derivatives
formula
Prior art date
Application number
CU20090070A
Other languages
English (en)
Other versions
CU23840B1 (es
Inventor
Eva Szentirmay
Eva Bozo
Gyoergy Keserue
Janos Eles
Monika Vastag
Katalin Hornok
Gyula Beke
Eva Schmidt
Istvan Vago
Sandor Farkas
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of CU20090070A7 publication Critical patent/CU20090070A7/es
Publication of CU23840B1 publication Critical patent/CU23840B1/es

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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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Abstract

La presente invención se refiere a nuevos derivados de sulfonamida de fórmula (I) ESPACIO PARA FÓRMULA donde R1-R5 y Z son como se definen en las reivindicaciones, y los antípodas ópticos o racematos y/o sales y/o hidratos y/o solvatos de los mismos, los cuales son antagonistas selectivos de la bradiquinina B1, a procesos para producir estos mismos compuestos, a las composiciones farmacológicas que los contienen y a su uso en la terapia o la prevención de estados dolorosos e inflamatorios.
CU2009000070A 2006-10-27 2009-04-27 Nuevos derivados de sulfonamida como antagonistas de la bradiquinina CU23840B1 (es)

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HU0600810A HUP0600810A3 (en) 2006-10-27 2006-10-27 New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
PCT/HU2007/000104 WO2008050168A1 (en) 2006-10-27 2007-10-27 New sulfonamide derivatives as bradykinin antagonists

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