AP3050A - New Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions comprising them - Google Patents

New Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions comprising them

Info

Publication number
AP3050A
AP3050A AP2011005935A AP2011005935A AP3050A AP 3050 A AP3050 A AP 3050A AP 2011005935 A AP2011005935 A AP 2011005935A AP 2011005935 A AP2011005935 A AP 2011005935A AP 3050 A AP3050 A AP 3050A
Authority
AP
ARIPO
Prior art keywords
preparation
new
pharmaceutical compositions
benzothiadiazepine
compounds
Prior art date
Application number
AP2011005935A
Other languages
English (en)
Other versions
AP2011005935A0 (en
Inventor
Alexis Cordi
Patrice Desos
Pierre Lestage
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of AP2011005935A0 publication Critical patent/AP2011005935A0/xx
Application granted granted Critical
Publication of AP3050A publication Critical patent/AP3050A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AP2011005935A 2009-03-20 2010-03-18 New Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions comprising them AP3050A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0901300A FR2943342B1 (fr) 2009-03-20 2009-03-20 Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
PCT/FR2010/000227 WO2010106249A1 (fr) 2009-03-20 2010-03-18 Derives de benzothiadiazepines en tant que modulateures des recepteurs ampa et nmda

Publications (2)

Publication Number Publication Date
AP2011005935A0 AP2011005935A0 (en) 2011-10-31
AP3050A true AP3050A (en) 2014-11-30

Family

ID=40863576

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2011005935A AP3050A (en) 2009-03-20 2010-03-18 New Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions comprising them

Country Status (45)

Country Link
US (1) US8236790B2 (xx)
EP (1) EP2246339B1 (xx)
JP (1) JP5437473B2 (xx)
KR (1) KR101431504B1 (xx)
CN (1) CN102361860B (xx)
AP (1) AP3050A (xx)
AR (1) AR075892A1 (xx)
AT (1) ATE513822T1 (xx)
AU (1) AU2010200815B2 (xx)
BR (1) BRPI1009200A2 (xx)
CA (1) CA2696705C (xx)
CL (1) CL2011002287A1 (xx)
CO (1) CO6361956A2 (xx)
CR (1) CR20110484A (xx)
CU (1) CU24030B1 (xx)
CY (1) CY1111807T1 (xx)
DK (1) DK2246339T3 (xx)
EA (1) EA020259B1 (xx)
EC (1) ECSP11011340A (xx)
ES (1) ES2368691T3 (xx)
FR (1) FR2943342B1 (xx)
GE (1) GEP20135862B (xx)
HK (1) HK1167404A1 (xx)
HN (1) HN2011002458A (xx)
HR (1) HRP20110626T1 (xx)
IL (1) IL215016A (xx)
JO (1) JO2780B1 (xx)
MA (1) MA33131B1 (xx)
MX (1) MX2011009638A (xx)
MY (1) MY154001A (xx)
NI (1) NI201100169A (xx)
NZ (1) NZ595082A (xx)
PE (1) PE20120113A1 (xx)
PL (1) PL2246339T3 (xx)
PT (1) PT2246339E (xx)
RS (1) RS51919B (xx)
SA (1) SA110310217B1 (xx)
SG (1) SG174274A1 (xx)
SI (1) SI2246339T1 (xx)
TN (1) TN2011000469A1 (xx)
TW (1) TWI388326B (xx)
UA (1) UA100477C2 (xx)
UY (1) UY32475A (xx)
WO (1) WO2010106249A1 (xx)
ZA (1) ZA201001905B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2464645T (pt) * 2009-07-27 2017-10-11 Gilead Sciences Inc Compostos heterocíclicos fusionados como moduladores do canal de iões
BR112012033402A2 (pt) 2010-07-02 2017-01-24 Gilead Sciences Inc moduladores de canais de íons conforme os compostos heterocíclicos fundidos
WO2012020848A1 (en) 2010-08-10 2012-02-16 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
BR112013028886A2 (pt) 2011-05-10 2016-08-09 Gilead Sciences Inc compostos heterocíclicos fundidos como moduladores dde canal de sódio
AU2015224425B2 (en) * 2011-07-01 2017-02-09 Gilead Sciences, Inc. Fused benzoxazepinones as ion channel modulators
NO3175985T3 (xx) 2011-07-01 2018-04-28
UY34171A (es) 2011-07-01 2013-01-31 Gilead Sciences Inc Compuestos heterocíclicos fusionados como moduladores del canal iónico
JP6134654B2 (ja) 2012-02-08 2017-05-24 武田薬品工業株式会社 複素環化合物およびその用途
CN111518055A (zh) * 2020-05-16 2020-08-11 西安都创医药科技有限公司 一种苯并硫氮杂卓氧化物的制备方法及其制备的产品及其应用
CN111548325A (zh) * 2020-05-16 2020-08-18 西安都创医药科技有限公司 一种卤代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111620838A (zh) * 2020-05-16 2020-09-04 西安都创医药科技有限公司 一种氯代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111574475B (zh) * 2020-06-03 2022-09-20 西安都创医药科技有限公司 卤代苯并硫杂卓氧化物的制备方法及其制备的产品及其应用
CN115368363B (zh) * 2021-05-17 2024-02-20 中山大学 一种手性或消旋的嘧啶并二氮杂环庚酮类化合物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021170A1 (fr) * 1992-04-15 1993-10-28 Rhone-Poulenc Rorer S.A. Derives d'acide 3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxyde-3-carboxylique, leur preparation et les medicaments les contenant
WO1999041246A1 (en) * 1998-02-11 1999-08-19 Du Pont Pharmaceuticals Company Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors
EP1655030A1 (fr) * 2004-11-03 2006-05-10 Les Laboratoires Servier Derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA991301B (en) * 1998-02-18 1999-09-13 Neurosearch As Glutamate receptor modulators.
US6156746A (en) * 1998-08-25 2000-12-05 Bristol-Myers Squibb Company 1,2,5-benzothiadiazepine-1,1-dioxides with n-2 imidazolylalkyl substituents
GB0209467D0 (en) * 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
DE10300973A1 (de) * 2003-01-14 2004-07-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Carbonsäuren und deren Ester, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2879201B1 (fr) * 2004-12-10 2007-02-16 Servier Lab Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021170A1 (fr) * 1992-04-15 1993-10-28 Rhone-Poulenc Rorer S.A. Derives d'acide 3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxyde-3-carboxylique, leur preparation et les medicaments les contenant
WO1999041246A1 (en) * 1998-02-11 1999-08-19 Du Pont Pharmaceuticals Company Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors
EP1655030A1 (fr) * 2004-11-03 2006-05-10 Les Laboratoires Servier Derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
RS51919B (en) 2012-02-29
CU24030B1 (es) 2014-10-02
UY32475A (es) 2010-09-30
IL215016A0 (en) 2011-11-30
CN102361860B (zh) 2014-09-10
ZA201001905B (en) 2010-11-24
EA020259B1 (ru) 2014-09-30
ATE513822T1 (de) 2011-07-15
CY1111807T1 (el) 2015-10-07
TN2011000469A1 (fr) 2013-03-27
GEP20135862B (en) 2013-06-25
ES2368691T3 (es) 2011-11-21
CN102361860A (zh) 2012-02-22
WO2010106249A1 (fr) 2010-09-23
MA33131B1 (fr) 2012-03-01
JP5437473B2 (ja) 2014-03-12
US8236790B2 (en) 2012-08-07
KR20110128209A (ko) 2011-11-28
MX2011009638A (es) 2011-09-28
CR20110484A (es) 2011-10-24
MY154001A (en) 2015-04-30
UA100477C2 (uk) 2012-12-25
SA110310217B1 (ar) 2013-06-15
EP2246339A1 (fr) 2010-11-03
AU2010200815A1 (en) 2010-10-07
HK1167404A1 (en) 2012-11-30
AR075892A1 (es) 2011-05-04
CL2011002287A1 (es) 2012-02-03
AP2011005935A0 (en) 2011-10-31
CU20110169A7 (es) 2012-02-15
US20100240635A1 (en) 2010-09-23
TW201036615A (en) 2010-10-16
SI2246339T1 (sl) 2011-09-30
EP2246339B1 (fr) 2011-06-22
HN2011002458A (es) 2014-05-19
NZ595082A (en) 2013-12-20
FR2943342B1 (fr) 2011-03-04
CA2696705C (fr) 2013-02-12
ECSP11011340A (es) 2011-10-31
JP2012520858A (ja) 2012-09-10
PT2246339E (pt) 2011-08-01
CA2696705A1 (fr) 2010-09-20
JO2780B1 (en) 2014-03-15
EA201101334A1 (ru) 2012-04-30
HRP20110626T1 (hr) 2011-10-31
PE20120113A1 (es) 2012-02-24
NI201100169A (es) 2012-01-11
AU2010200815B2 (en) 2015-05-07
SG174274A1 (en) 2011-10-28
CO6361956A2 (es) 2012-01-20
TWI388326B (zh) 2013-03-11
BRPI1009200A2 (pt) 2017-06-13
KR101431504B1 (ko) 2014-08-20
FR2943342A1 (fr) 2010-09-24
DK2246339T3 (da) 2011-10-10
IL215016A (en) 2013-08-29
PL2246339T3 (pl) 2011-11-30

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