ECSP099679A - Nuevos compuestos y sus usos 707 - Google Patents

Nuevos compuestos y sus usos 707

Info

Publication number
ECSP099679A
ECSP099679A EC2009009679A ECSP099679A ECSP099679A EC SP099679 A ECSP099679 A EC SP099679A EC 2009009679 A EC2009009679 A EC 2009009679A EC SP099679 A ECSP099679 A EC SP099679A EC SP099679 A ECSP099679 A EC SP099679A
Authority
EC
Ecuador
Prior art keywords
new compounds
therapy
contain
processes
formula
Prior art date
Application number
EC2009009679A
Other languages
English (en)
Inventor
Brian J Roberts
Piotr Raubo
Matthew Hallam
Barrie Martin
Stephen St-Gallay
Paul Willis
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ECSP099679A publication Critical patent/ECSP099679A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Abstract

La presente invención se refiere a derivados de isoquinolinona de fórmula (I): donde R1, R2, R3, R4, R5, R6 y R7 son los definidos aquí; a procesos para su preparación, a composiciones farmacéuticas que los contienen y a su uso en terapia.
EC2009009679A 2007-04-05 2009-10-07 Nuevos compuestos y sus usos 707 ECSP099679A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91023507P 2007-04-05 2007-04-05
US97952307P 2007-10-12 2007-10-12

Publications (1)

Publication Number Publication Date
ECSP099679A true ECSP099679A (es) 2009-11-30

Family

ID=39560895

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009679A ECSP099679A (es) 2007-04-05 2009-10-07 Nuevos compuestos y sus usos 707

Country Status (19)

Country Link
US (1) US8012979B2 (es)
EP (1) EP2144881B1 (es)
JP (1) JP5400759B2 (es)
KR (1) KR20100016218A (es)
CN (1) CN101679275B (es)
AR (1) AR065965A1 (es)
AU (1) AU2008235359B2 (es)
BR (1) BRPI0810047A2 (es)
CA (1) CA2681221A1 (es)
CL (1) CL2008000973A1 (es)
CO (1) CO6230983A2 (es)
EC (1) ECSP099679A (es)
IL (1) IL201015A0 (es)
MX (1) MX2009010225A (es)
PE (1) PE20090141A1 (es)
RU (1) RU2472781C2 (es)
TW (1) TW200845988A (es)
UY (1) UY31005A1 (es)
WO (1) WO2008122765A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR073711A1 (es) * 2008-10-01 2010-11-24 Astrazeneca Ab Derivados de isoquinolina
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CN103864684A (zh) * 2012-12-07 2014-06-18 天津科技大学 一种新颖的3,4-二氢-1(2h)异喹啉类衍生物的合成与抗肿瘤药物的应用
CN105829285A (zh) * 2013-10-23 2016-08-03 中外制药株式会社 喹唑啉酮和异喹啉酮衍生物
FR3017868A1 (fr) * 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN106674254B (zh) * 2016-12-21 2019-03-15 广东省中医院 一类喹诺酮羧酸化合物及其中间体、制备方法以及应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU176214B (en) * 1977-05-18 1981-01-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 5,6-dihydro-imidazo-square bracket-5,1-a-square bracket closed-isoquinolin derivatives
EP1163237B1 (en) 1999-03-17 2004-05-06 AstraZeneca AB Amide derivatives
US7402595B2 (en) * 2002-02-13 2008-07-22 Takeda Pharmaceutical Company Limited JNK inhibitor
US6867320B2 (en) * 2002-02-21 2005-03-15 Asahi Kasei Pharma Corporation Substituted phenylalkanoic acid derivatives and use thereof
WO2003070686A1 (fr) * 2002-02-21 2003-08-28 Asahi Kasei Pharma Corporation Derive de l'acide phenylalcanoyle substitue et son utilisation
BRPI0413297B1 (pt) 2003-08-06 2014-01-21 Processo para operar uma oxidação parcial contínua em fase gasosa catalisada de maneira heterogênea de pelo menos um composto orgânico
WO2005016862A1 (en) * 2003-08-14 2005-02-24 Asahi Kasei Pharma Corporation Substituted arylalkanoic acid derivative and use thereof
JP2007008816A (ja) 2003-10-15 2007-01-18 Ube Ind Ltd 新規イソキノリン誘導体
US20070054916A1 (en) * 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
EP1831174B1 (en) * 2004-12-24 2011-03-02 AstraZeneca AB Amide derivatives
TW200728277A (en) * 2005-06-29 2007-08-01 Palau Pharma Sa Bicyclic derivatives as P38 inhibitors
RS52241B (en) 2005-07-26 2012-10-31 Sanofi CYCLOHEXYLAMINE ISOHINOLONE DERIVATIVES AS RHO-KINASE INHIBITORS

Also Published As

Publication number Publication date
JP2010523533A (ja) 2010-07-15
US20090023746A1 (en) 2009-01-22
EP2144881A1 (en) 2010-01-20
JP5400759B2 (ja) 2014-01-29
BRPI0810047A2 (pt) 2014-10-21
AU2008235359B2 (en) 2011-12-15
CL2008000973A1 (es) 2009-01-02
US8012979B2 (en) 2011-09-06
KR20100016218A (ko) 2010-02-12
AU2008235359A1 (en) 2008-10-16
CO6230983A2 (es) 2010-12-20
UY31005A1 (es) 2008-11-28
CN101679275A (zh) 2010-03-24
RU2009136246A (ru) 2011-05-10
WO2008122765A1 (en) 2008-10-16
AR065965A1 (es) 2009-07-15
MX2009010225A (es) 2009-12-14
CN101679275B (zh) 2013-07-31
EP2144881B1 (en) 2012-06-20
PE20090141A1 (es) 2009-04-30
TW200845988A (en) 2008-12-01
RU2472781C2 (ru) 2013-01-20
IL201015A0 (en) 2010-05-17
CA2681221A1 (en) 2008-10-16

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