MX344927B - Composición farmacéutica que contiene derivado de quinolina. - Google Patents

Composición farmacéutica que contiene derivado de quinolina.

Info

Publication number
MX344927B
MX344927B MX2014010594A MX2014010594A MX344927B MX 344927 B MX344927 B MX 344927B MX 2014010594 A MX2014010594 A MX 2014010594A MX 2014010594 A MX2014010594 A MX 2014010594A MX 344927 B MX344927 B MX 344927B
Authority
MX
Mexico
Prior art keywords
pharmaceutical composition
containing pharmaceutical
quinoline derivative
formula
hydrogen atom
Prior art date
Application number
MX2014010594A
Other languages
English (en)
Inventor
Masashi Bando
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43607048&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX344927(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MX344927B publication Critical patent/MX344927B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describe una composición farmacéutica que contiene: un compuesto representado por la fórmula (I), una sal farmacológica aceptable del mismo, o un solvato del compuesto o sal; y una sustancia básica. La composición farmacéutica tiene excelente capacidad de disolución, es estable incluso después almacenamiento por tiempo prolongado, y es útil como un agente profiláctico/terapéutico para tumores. (En la fórmula, R1 representa un átomo de hidrógeno, un grupo C1-6 alquilo o un grupo C3-8 cicloalquilo; y R2 representa un átomo de hidrógeno o un grupo metoxi.).
MX2014010594A 2009-08-19 2010-08-16 Composición farmacéutica que contiene derivado de quinolina. MX344927B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009190145 2009-08-19
PCT/JP2010/063804 WO2011021597A1 (ja) 2009-08-19 2010-08-16 キノリン誘導体含有医薬組成物

Publications (1)

Publication Number Publication Date
MX344927B true MX344927B (es) 2017-01-11

Family

ID=43607048

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014010594A MX344927B (es) 2009-08-19 2010-08-16 Composición farmacéutica que contiene derivado de quinolina.
MX2012002011A MX2012002011A (es) 2009-08-19 2010-08-16 Composicion farmaceutica que contiene derivado de quinolina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2012002011A MX2012002011A (es) 2009-08-19 2010-08-16 Composicion farmaceutica que contiene derivado de quinolina.

Country Status (33)

Country Link
US (3) US20120077842A1 (es)
EP (1) EP2468281B1 (es)
JP (1) JP5048871B2 (es)
KR (1) KR101496395B1 (es)
CN (1) CN102470133B (es)
AU (1) AU2010285740C1 (es)
BR (1) BR112012003592B8 (es)
CA (1) CA2771403C (es)
CL (1) CL2012000412A1 (es)
CO (1) CO6440512A2 (es)
CY (1) CY1117481T1 (es)
DK (1) DK2468281T3 (es)
ES (1) ES2564797T3 (es)
HK (2) HK1167607A1 (es)
HR (1) HRP20160283T1 (es)
HU (1) HUE026957T2 (es)
IL (1) IL217197A (es)
MA (1) MA33581B1 (es)
ME (1) ME02359B (es)
MX (2) MX344927B (es)
MY (1) MY162940A (es)
NZ (1) NZ598291A (es)
PE (1) PE20121030A1 (es)
PL (1) PL2468281T3 (es)
RS (1) RS54686B1 (es)
RU (1) RU2548673C3 (es)
SG (1) SG178009A1 (es)
SI (1) SI2468281T1 (es)
SM (1) SMT201600077B (es)
TH (1) TH121482A (es)
UA (1) UA105671C2 (es)
WO (1) WO2011021597A1 (es)
ZA (1) ZA201108697B (es)

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WO2006030826A1 (ja) 2004-09-17 2006-03-23 Eisai R & D Management Co., Ltd. 医薬組成物
EP1925676A4 (en) 2005-08-02 2010-11-10 Eisai R&D Man Co Ltd TEST METHOD FOR THE EFFECT OF A VASCULARIZATION INHIBITOR
CN102716490A (zh) * 2005-09-01 2012-10-10 卫材R&D管理有限公司 药物组合物的崩解性的改善方法
JPWO2007052849A1 (ja) 2005-11-07 2009-04-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質とｃ−ｋｉｔキナーゼ阻害物質との併用
WO2007136103A1 (ja) * 2006-05-18 2007-11-29 Eisai R & D Management Co., Ltd. 甲状腺癌に対する抗腫瘍剤
WO2008026748A1 (fr) * 2006-08-28 2008-03-06 Eisai R & D Management Co., Ltd. Agent antitumoral pour cancer gastrique non différencié
CN101600694A (zh) * 2007-01-29 2009-12-09 卫材R&D管理有限公司 未分化型胃癌治疗用组合物
CA2704000C (en) * 2007-11-09 2016-12-13 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
MX2012014776A (es) 2010-06-25 2013-01-29 Eisai R&D Man Co Ltd Agente antitumoral que emplea compuestos con efecto inhibidor de cinasas combinados.
AU2012246490B2 (en) 2011-04-18 2016-08-04 Eisai R&D Management Co., Ltd. Therapeutic agent for tumor
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KR20150098605A (ko) 2012-12-21 2015-08-28 에자이 알앤드디 매니지먼트 가부시키가이샤 퀴놀린 유도체의 비정질 형태 및 그의 제조방법
JP6411379B2 (ja) 2013-05-14 2018-10-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 レンバチニブ化合物に対する子宮内膜がん対象の応答性を予測及び評価するためのバイオマーカー
ES2926687T3 (es) 2014-08-28 2022-10-27 Eisai R&D Man Co Ltd Derivado de quinolina muy puro y método para su producción
CN106139156B (zh) * 2014-11-14 2019-01-29 江苏恒瑞医药股份有限公司 一种含有喹啉衍生物或其盐的药物组合物
US20180028662A1 (en) * 2015-02-25 2018-02-01 Eisai R&D Management Co., Ltd. Method for Suppressing Bitterness of Quinoline Derivative
CA2978226A1 (en) 2015-03-04 2016-09-09 Merck Sharpe & Dohme Corp. Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
CN106075456A (zh) * 2015-04-27 2016-11-09 南京圣和药业股份有限公司 一种含乐伐替尼的药物组合物及其应用
MX2017014799A (es) * 2015-05-21 2023-02-23 Crystal Pharmatech Co Ltd Forma cristalina novedosa de mesilato de lenvatinib y procedimiento de preparacion de la misma.
CA2988707C (en) 2015-06-16 2023-10-10 Eisai R&D Management Co., Ltd. Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer
WO2017028660A1 (zh) * 2015-08-17 2017-02-23 江苏恒瑞医药股份有限公司 一种含有喹啉衍生物或其盐的药物组合物
RU2606592C1 (ru) * 2015-10-07 2017-01-10 Открытое Акционерное Общество "Татхимфармпрепараты" Фармацевтическая композиция, содержащая кальциевую соль розувастатина (варианты)
CZ2016240A3 (cs) 2016-04-27 2017-11-08 Zentiva, K.S. Soli lenvatinibu
EP3384901B1 (en) 2017-04-04 2024-08-14 Synthon B.V. Pharmaceutical composition comprising lenvatinib mesylate
US10583133B2 (en) 2018-03-12 2020-03-10 Shilpa Medicare Limited Pharmaceutical compositions of lenvatinib
CN110404079B (zh) * 2018-04-27 2023-01-24 北京睿创康泰医药研究院有限公司 一种不含碳酸盐、低基因毒性杂质含量的喹啉衍生物或其盐的药物组合物
ES2970132T3 (es) * 2018-10-04 2024-05-27 Synthon Bv Composición farmacéutica que comprende besilato de lenvatinib
PT3632436T (pt) 2018-10-04 2022-07-22 Synthon Bv Composição farmacêutica compreendendo sais de lenvatinib
CN113087666B (zh) * 2020-01-09 2021-12-14 南京正大天晴制药有限公司 无定形喹啉甲酰胺衍生物的制备方法
CN113491695A (zh) * 2020-03-18 2021-10-12 上海博志研新药物技术有限公司 一种仑伐替尼药物组合物、其制备方法及应用
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Also Published As

Publication number Publication date
KR101496395B1 (ko) 2015-02-26
BR112012003592A2 (pt) 2016-03-15
AU2010285740A1 (en) 2011-12-15
CA2771403A1 (en) 2011-02-24
EP2468281A1 (en) 2012-06-27
SI2468281T1 (sl) 2016-05-31
PE20121030A1 (es) 2012-08-18
TH121482A (th) 2013-02-28
RU2548673C2 (ru) 2015-04-20
NZ598291A (en) 2013-02-22
DK2468281T3 (en) 2016-03-21
CA2771403C (en) 2015-02-24
CN102470133A (zh) 2012-05-23
HUE026957T2 (en) 2016-07-28
SMT201600077B (it) 2016-04-29
MX2012002011A (es) 2012-03-26
AU2010285740C1 (en) 2016-03-17
CO6440512A2 (es) 2012-05-15
UA105671C2 (uk) 2014-06-10
IL217197A0 (en) 2012-02-29
ES2564797T3 (es) 2016-03-29
JP5048871B2 (ja) 2012-10-17
RS54686B1 (en) 2016-08-31
BR112012003592B1 (pt) 2020-11-03
AU2010285740B2 (en) 2014-12-04
CY1117481T1 (el) 2017-04-26
WO2011021597A1 (ja) 2011-02-24
CN102470133B (zh) 2013-08-28
EP2468281A4 (en) 2013-01-23
SG178009A1 (en) 2012-03-29
US20210228722A1 (en) 2021-07-29
US20120077842A1 (en) 2012-03-29
MY162940A (en) 2017-07-31
HK1169599A1 (zh) 2013-02-01
US20130296365A1 (en) 2013-11-07
BR112012003592B8 (pt) 2021-05-25
RU2548673C3 (ru) 2018-07-20
JPWO2011021597A1 (ja) 2013-01-24
KR20120055559A (ko) 2012-05-31
ME02359B (me) 2016-06-20
PL2468281T3 (pl) 2016-06-30
HRP20160283T1 (hr) 2016-05-06
HK1167607A1 (en) 2012-12-07
MA33581B1 (fr) 2012-09-01
IL217197A (en) 2016-08-31
RU2012103471A (ru) 2013-09-27
CL2012000412A1 (es) 2012-08-31
EP2468281B1 (en) 2016-01-27
ZA201108697B (en) 2012-07-25

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