MX2013002694A - Derivados de tetrahidroquinolina usados como activadores de proteina cinasa activada por monofosfato de adenosina. - Google Patents
Derivados de tetrahidroquinolina usados como activadores de proteina cinasa activada por monofosfato de adenosina.Info
- Publication number
- MX2013002694A MX2013002694A MX2013002694A MX2013002694A MX2013002694A MX 2013002694 A MX2013002694 A MX 2013002694A MX 2013002694 A MX2013002694 A MX 2013002694A MX 2013002694 A MX2013002694 A MX 2013002694A MX 2013002694 A MX2013002694 A MX 2013002694A
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives used
- tetrahydroquinoline derivatives
- ampk activators
- sup
- ampk
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de la Fórmula (I), o una sal o éster farmacéuticamente aceptable del mismo, en donde R1 a R7 tienen el significado dado en la reivindicación 1, puede ser utilizado como un medicamento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010077907 | 2010-10-20 | ||
PCT/EP2011/068053 WO2012052372A1 (en) | 2010-10-20 | 2011-10-17 | Tetrahydroquinoline derivatives used as ampk activators |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2013002694A true MX2013002694A (es) | 2013-05-22 |
Family
ID=44860331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013002694A MX2013002694A (es) | 2010-10-20 | 2011-10-17 | Derivados de tetrahidroquinolina usados como activadores de proteina cinasa activada por monofosfato de adenosina. |
Country Status (10)
Country | Link |
---|---|
US (1) | US8546427B2 (es) |
EP (1) | EP2630124B1 (es) |
JP (1) | JP6104807B2 (es) |
KR (1) | KR101854485B1 (es) |
BR (1) | BR112013009640A2 (es) |
CA (1) | CA2814594C (es) |
ES (1) | ES2527194T3 (es) |
MX (1) | MX2013002694A (es) |
RU (1) | RU2615758C2 (es) |
WO (1) | WO2012052372A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
EP3089748A4 (en) | 2014-01-02 | 2017-09-27 | Massachusetts Eye & Ear Infirmary | Treating ocular neovascularization |
JP6755589B2 (ja) * | 2015-04-30 | 2020-09-16 | 国立大学法人京都大学 | Ampkのリン酸化を亢進する化合物を有効成分とする組成物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE319451T1 (de) * | 2001-07-02 | 2006-03-15 | Akzo Nobel Nv | Tetrahydrochinolin-derivate |
DE10236910A1 (de) * | 2002-08-12 | 2004-03-11 | Grünenthal GmbH | Substituierte 1,2,3,4-Tetrahydrochinolinderivate |
WO2004072041A1 (en) * | 2003-02-12 | 2004-08-26 | Care X S.A. | Tetrahydroquinolines as agonists of liver- x receptors |
US7138412B2 (en) * | 2003-03-11 | 2006-11-21 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives useful as serine protease inhibitors |
RU2375354C2 (ru) * | 2003-12-20 | 2009-12-10 | Мерк Патент Гмбх | Производные 2-(гетеро)арил-замещенных тетрагидрохинолинов |
US8344137B2 (en) * | 2010-04-14 | 2013-01-01 | Hoffman-La Roche Inc. | 3,3-dimethyl tetrahydroquinoline derivatives |
-
2011
- 2011-10-13 US US13/272,259 patent/US8546427B2/en not_active Expired - Fee Related
- 2011-10-17 RU RU2013120137A patent/RU2615758C2/ru not_active IP Right Cessation
- 2011-10-17 KR KR1020137012627A patent/KR101854485B1/ko active IP Right Grant
- 2011-10-17 JP JP2013534269A patent/JP6104807B2/ja not_active Expired - Fee Related
- 2011-10-17 MX MX2013002694A patent/MX2013002694A/es active IP Right Grant
- 2011-10-17 BR BR112013009640A patent/BR112013009640A2/pt not_active Application Discontinuation
- 2011-10-17 CA CA2814594A patent/CA2814594C/en not_active Expired - Fee Related
- 2011-10-17 WO PCT/EP2011/068053 patent/WO2012052372A1/en active Application Filing
- 2011-10-17 ES ES11774017.5T patent/ES2527194T3/es active Active
- 2011-10-17 EP EP11774017.5A patent/EP2630124B1/en not_active Not-in-force
Also Published As
Publication number | Publication date |
---|---|
BR112013009640A2 (pt) | 2016-07-12 |
JP6104807B2 (ja) | 2017-03-29 |
US20120101127A1 (en) | 2012-04-26 |
KR101854485B1 (ko) | 2018-05-03 |
JP2013541551A (ja) | 2013-11-14 |
KR20140002644A (ko) | 2014-01-08 |
EP2630124B1 (en) | 2014-11-19 |
ES2527194T3 (es) | 2015-01-21 |
RU2615758C2 (ru) | 2017-04-11 |
RU2013120137A (ru) | 2014-11-27 |
CA2814594C (en) | 2018-06-12 |
WO2012052372A1 (en) | 2012-04-26 |
CA2814594A1 (en) | 2012-04-26 |
EP2630124A1 (en) | 2013-08-28 |
US8546427B2 (en) | 2013-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |