MX2009007260A - Derivados de imidazol como inhibidores de proteina de huso de cinesina (eg-5). - Google Patents

Derivados de imidazol como inhibidores de proteina de huso de cinesina (eg-5).

Info

Publication number
MX2009007260A
MX2009007260A MX2009007260A MX2009007260A MX2009007260A MX 2009007260 A MX2009007260 A MX 2009007260A MX 2009007260 A MX2009007260 A MX 2009007260A MX 2009007260 A MX2009007260 A MX 2009007260A MX 2009007260 A MX2009007260 A MX 2009007260A
Authority
MX
Mexico
Prior art keywords
inhibitors
compounds
cyclized derivatives
pharmaceutically acceptable
cyclized
Prior art date
Application number
MX2009007260A
Other languages
English (en)
Inventor
Weibo Wang
Hong Yang
Paul A Barsanti
Rustum Boyce
Eric Martin
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2009007260A publication Critical patent/MX2009007260A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

La presente invención se refiere a nuevos compuestos de imidazol sustituido que tienen la siguiente fórmula (I), y a las sales farmacéuticamente aceptables, ésteres, o pro-fármacos de los mismos, a composiciones de los compuestos junto con vehículos farmacéuticamente aceptables, y a los usos de los compuestos: (ver fórmula (I)).
MX2009007260A 2007-01-05 2008-01-03 Derivados de imidazol como inhibidores de proteina de huso de cinesina (eg-5). MX2009007260A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88374007P 2007-01-05 2007-01-05
PCT/US2008/050149 WO2008086122A2 (en) 2007-01-05 2008-01-03 Imidazole derivatives as kinesin spindle protein inhibitors (eg-5)

Publications (1)

Publication Number Publication Date
MX2009007260A true MX2009007260A (es) 2009-07-10

Family

ID=39577804

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009007260A MX2009007260A (es) 2007-01-05 2008-01-03 Derivados de imidazol como inhibidores de proteina de huso de cinesina (eg-5).

Country Status (30)

Country Link
US (3) US7820646B2 (es)
EP (1) EP2106399A2 (es)
JP (1) JP2010515687A (es)
KR (1) KR20090097210A (es)
CN (1) CN101622247A (es)
AR (1) AR064760A1 (es)
AU (1) AU2008205169B2 (es)
BR (1) BRPI0806264A2 (es)
CA (1) CA2674318A1 (es)
CL (1) CL2008000029A1 (es)
CO (1) CO6561828A2 (es)
CR (1) CR10879A (es)
DO (1) DOP2009000169A (es)
EA (1) EA200900924A1 (es)
EC (1) ECSP099485A (es)
GE (1) GEP20125415B (es)
GT (1) GT200900192A (es)
HN (1) HN2009001262A (es)
MA (1) MA31080B1 (es)
MX (1) MX2009007260A (es)
NI (1) NI200900134A (es)
NZ (1) NZ577727A (es)
PE (1) PE20081850A1 (es)
SM (1) SMP200900065B (es)
SV (1) SV2009003325A (es)
TN (1) TN2009000287A1 (es)
TW (1) TW200836722A (es)
UA (1) UA97821C2 (es)
WO (1) WO2008086122A2 (es)
ZA (1) ZA200904175B (es)

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US8252832B2 (en) 2007-12-14 2012-08-28 Novartis Ag Kinesin inhibitors as cancer therapeutics
CN102844307A (zh) 2010-04-15 2012-12-26 诺瓦提斯公司 作为ksp抑制剂的三唑化合物
JP2013525290A (ja) * 2010-04-15 2013-06-20 ノバルティス アーゲー Ｋｓｐ阻害剤としてのオキサゾールおよびチアゾール化合物
EP2390247A1 (en) * 2010-05-26 2011-11-30 Netherlands Organisation for Scientific Research (Advanced Chemical Technologies for Sustainability) Preparation of caprolactone, caprolactam, 2,5-tetrahydrofuran dimethanol, 1,6-hexanediol or 1,2,6-hexanetriol from 5-hydroxymethyl-2-furfuraldehyde
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
EP2968591A1 (en) * 2013-03-15 2016-01-20 Novartis AG Cell proliferation inhibitors and conjugates thereof
US9498540B2 (en) 2013-03-15 2016-11-22 Novartis Ag Cell proliferation inhibitors and conjugates thereof
BR112016014830A2 (pt) * 2013-12-23 2017-09-19 Bayer Pharma AG Conjugados de fármaco de anticorpo (adcs) com inibidores de ksp
CN114917361A (zh) * 2015-06-22 2022-08-19 拜耳医药股份有限公司 具有酶可裂解基团的抗体药物缀合物（adc）和抗体前药缀合物（apdc）
CN105330657B (zh) * 2015-12-08 2019-05-21 华润双鹤药业股份有限公司 5-氯-2-[5-(r)-甲基-1,4-二氮杂环庚烷-1-]苯并恶唑的制备方法
CN105367506B (zh) * 2015-12-08 2021-02-05 华润双鹤药业股份有限公司 手性高哌嗪环的制备方法
EP3919518A1 (en) 2016-06-15 2021-12-08 Bayer Pharma Aktiengesellschaft Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies
EP3558387B1 (de) 2016-12-21 2021-10-20 Bayer Pharma Aktiengesellschaft Spezifische antikörper-wirkstoff-konjugate (adcs) mit ksp-inhibitoren
EP3558388A1 (de) 2016-12-21 2019-10-30 Bayer Pharma Aktiengesellschaft Binder-wirkstoff-konjugate (adcs) mit enzymatisch spaltbaren gruppen
CA3103327A1 (en) 2018-06-18 2019-12-26 Bayer Aktiengesellschaft Binder/active agent conjugates directed against cxcr5, having enzymatically cleavable linkers and improved activity profile

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Also Published As

Publication number Publication date
AU2008205169B2 (en) 2012-02-02
US20110003791A1 (en) 2011-01-06
EP2106399A2 (en) 2009-10-07
CL2008000029A1 (es) 2008-04-04
AR064760A1 (es) 2009-04-22
BRPI0806264A2 (pt) 2011-08-30
JP2010515687A (ja) 2010-05-13
GEP20125415B (en) 2012-03-12
NI200900134A (es) 2010-07-05
KR20090097210A (ko) 2009-09-15
WO2008086122A2 (en) 2008-07-17
TW200836722A (en) 2008-09-16
AU2008205169A1 (en) 2008-07-17
TN2009000287A1 (en) 2010-12-31
PE20081850A1 (es) 2009-02-05
SV2009003325A (es) 2011-08-09
CR10879A (es) 2009-08-05
WO2008086122A3 (en) 2008-10-16
NZ577727A (en) 2012-03-30
HN2009001262A (es) 2012-01-09
CN101622247A (zh) 2010-01-06
ZA200904175B (en) 2010-04-28
SMP200900065B (it) 2010-09-10
EA200900924A1 (ru) 2009-12-30
ECSP099485A (es) 2009-08-28
CA2674318A1 (en) 2008-07-17
GT200900192A (es) 2010-06-24
UA97821C2 (en) 2012-03-26
US20080207589A1 (en) 2008-08-28
MA31080B1 (fr) 2010-01-04
SMAP200900065A (it) 2009-09-07
CO6561828A2 (es) 2012-11-15
US20120189623A1 (en) 2012-07-26
DOP2009000169A (es) 2009-08-31
US7820646B2 (en) 2010-10-26

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