SMP200900065B - Derivati ciclizzati come inibitori di EG-5. - Google Patents
Derivati ciclizzati come inibitori di EG-5.Info
- Publication number
- SMP200900065B SMP200900065B SM200900065T SM200900065T SMP200900065B SM P200900065 B SMP200900065 B SM P200900065B SM 200900065 T SM200900065 T SM 200900065T SM 200900065 T SM200900065 T SM 200900065T SM P200900065 B SMP200900065 B SM P200900065B
- Authority
- SM
- San Marino
- Prior art keywords
- inhibitors
- cyclized derivatives
- cyclized
- derivatives
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88374007P | 2007-01-05 | 2007-01-05 | |
| PCT/US2008/050149 WO2008086122A2 (en) | 2007-01-05 | 2008-01-03 | Imidazole derivatives as kinesin spindle protein inhibitors (eg-5) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SMAP200900065A SMAP200900065A (it) | 2009-09-07 |
| SMP200900065B true SMP200900065B (it) | 2010-09-10 |
Family
ID=39577804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM200900065T SMP200900065B (it) | 2007-01-05 | 2009-07-23 | Derivati ciclizzati come inibitori di EG-5. |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US7820646B2 (it) |
| EP (1) | EP2106399A2 (it) |
| JP (1) | JP2010515687A (it) |
| KR (1) | KR20090097210A (it) |
| CN (1) | CN101622247A (it) |
| AR (1) | AR064760A1 (it) |
| AU (1) | AU2008205169B2 (it) |
| BR (1) | BRPI0806264A2 (it) |
| CA (1) | CA2674318A1 (it) |
| CL (1) | CL2008000029A1 (it) |
| CO (1) | CO6561828A2 (it) |
| CR (1) | CR10879A (it) |
| DO (1) | DOP2009000169A (it) |
| EA (1) | EA200900924A1 (it) |
| EC (1) | ECSP099485A (it) |
| GE (1) | GEP20125415B (it) |
| GT (1) | GT200900192A (it) |
| HN (1) | HN2009001262A (it) |
| MA (1) | MA31080B1 (it) |
| MX (1) | MX2009007260A (it) |
| NI (1) | NI200900134A (it) |
| NZ (1) | NZ577727A (it) |
| PE (1) | PE20081850A1 (it) |
| SM (1) | SMP200900065B (it) |
| SV (1) | SV2009003325A (it) |
| TN (1) | TN2009000287A1 (it) |
| TW (1) | TW200836722A (it) |
| UA (1) | UA97821C2 (it) |
| WO (1) | WO2008086122A2 (it) |
| ZA (1) | ZA200904175B (it) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8252832B2 (en) | 2007-12-14 | 2012-08-28 | Novartis Ag | Kinesin inhibitors as cancer therapeutics |
| CN102844307A (zh) | 2010-04-15 | 2012-12-26 | 诺瓦提斯公司 | 作为ksp抑制剂的三唑化合物 |
| JP2013525290A (ja) * | 2010-04-15 | 2013-06-20 | ノバルティス アーゲー | Ｋｓｐ阻害剤としてのオキサゾールおよびチアゾール化合物 |
| EP2390247A1 (en) * | 2010-05-26 | 2011-11-30 | Netherlands Organisation for Scientific Research (Advanced Chemical Technologies for Sustainability) | Preparation of caprolactone, caprolactam, 2,5-tetrahydrofuran dimethanol, 1,6-hexanediol or 1,2,6-hexanetriol from 5-hydroxymethyl-2-furfuraldehyde |
| GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
| CN105451773A (zh) * | 2013-03-15 | 2016-03-30 | 诺华股份有限公司 | 细胞增殖抑制剂及其缀合物 |
| US9498540B2 (en) | 2013-03-15 | 2016-11-22 | Novartis Ag | Cell proliferation inhibitors and conjugates thereof |
| BR112016014830A2 (pt) * | 2013-12-23 | 2017-09-19 | Bayer Pharma AG | Conjugados de fármaco de anticorpo (adcs) com inibidores de ksp |
| AU2016282723B2 (en) * | 2015-06-22 | 2021-09-23 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (ADCs) and antibody prodrug conjugates (APDCs) with enzymatically cleavable groups |
| CN105367506B (zh) * | 2015-12-08 | 2021-02-05 | 华润双鹤药业股份有限公司 | 手性高哌嗪环的制备方法 |
| CN105330657B (zh) * | 2015-12-08 | 2019-05-21 | 华润双鹤药业股份有限公司 | 5-氯-2-[5-(r)-甲基-1,4-二氮杂环庚烷-1-]苯并恶唑的制备方法 |
| EP3471776B1 (en) | 2016-06-15 | 2022-05-04 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates with ksp inhibitors and anti-cd123-antibodies |
| JP7066714B2 (ja) | 2016-12-21 | 2022-05-13 | バイエル・ファルマ・アクティエンゲゼルシャフト | 酵素的に切断可能な基を有する抗体薬物コンジュゲート（ａｄｃ） |
| JP7030811B2 (ja) | 2016-12-21 | 2022-03-07 | バイエル・ファルマ・アクティエンゲゼルシャフト | Ｋｓｐ阻害剤を有する特異的抗体－薬物コンジュゲート（ａｄｃ） |
| JP2021527640A (ja) | 2018-06-18 | 2021-10-14 | バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 酵素的に切断可能なリンカーおよび改善された活性プロファイルを有する、ｃｘｃｒ５に対して向けられるバインダー／活性薬剤複合体 |
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| RU2007118523A (ru) | 2004-10-19 | 2008-11-27 | Новартис Вэксинс Энд Диагностикс Инк. (Us) | Производные индола и бензимидазола |
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-
2008
- 2008-01-03 BR BRPI0806264-1A patent/BRPI0806264A2/pt not_active IP Right Cessation
- 2008-01-03 NZ NZ577727A patent/NZ577727A/en not_active IP Right Cessation
- 2008-01-03 GE GEAP200811346A patent/GEP20125415B/en unknown
- 2008-01-03 KR KR1020097016289A patent/KR20090097210A/ko not_active Application Discontinuation
- 2008-01-03 JP JP2009544977A patent/JP2010515687A/ja active Pending
- 2008-01-03 AU AU2008205169A patent/AU2008205169B2/en not_active Ceased
- 2008-01-03 US US11/969,164 patent/US7820646B2/en not_active Expired - Fee Related
- 2008-01-03 WO PCT/US2008/050149 patent/WO2008086122A2/en active Application Filing
- 2008-01-03 CN CN200880007148A patent/CN101622247A/zh active Pending
- 2008-01-03 EP EP08705667A patent/EP2106399A2/en not_active Withdrawn
- 2008-01-03 CA CA002674318A patent/CA2674318A1/en not_active Abandoned
- 2008-01-03 MX MX2009007260A patent/MX2009007260A/es not_active Application Discontinuation
- 2008-01-03 EA EA200900924A patent/EA200900924A1/ru unknown
- 2008-01-04 TW TW097100432A patent/TW200836722A/zh unknown
- 2008-01-04 AR ARP080100042A patent/AR064760A1/es not_active Application Discontinuation
- 2008-01-04 PE PE2008000091A patent/PE20081850A1/es not_active Application Discontinuation
- 2008-01-04 CL CL200800029A patent/CL2008000029A1/es unknown
- 2008-03-01 UA UAA200906929A patent/UA97821C2/ru unknown
-
2009
- 2009-06-15 ZA ZA200904175A patent/ZA200904175B/xx unknown
- 2009-06-19 CR CR10879A patent/CR10879A/es unknown
- 2009-06-30 MA MA32061A patent/MA31080B1/fr unknown
- 2009-07-02 NI NI200900134A patent/NI200900134A/es unknown
- 2009-07-02 CO CO09068496A patent/CO6561828A2/es not_active Application Discontinuation
- 2009-07-02 DO DO2009000169A patent/DOP2009000169A/es unknown
- 2009-07-03 EC EC2009009485A patent/ECSP099485A/es unknown
- 2009-07-03 TN TNP2009000287A patent/TN2009000287A1/fr unknown
- 2009-07-03 GT GT200900192A patent/GT200900192A/es unknown
- 2009-07-03 HN HN2009001262A patent/HN2009001262A/es unknown
- 2009-07-03 SV SV2009003325A patent/SV2009003325A/es not_active Application Discontinuation
- 2009-07-23 SM SM200900065T patent/SMP200900065B/it unknown
-
2010
- 2010-09-15 US US12/882,473 patent/US20110003791A1/en not_active Abandoned
-
2012
- 2012-04-03 US US13/438,569 patent/US20120189623A1/en not_active Abandoned
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| ATE555107T1 (de) | 2-aza-bicyclo-ä2,2,1-üheptan-derivate | |
| BRPI0820112A2 (pt) | Derivados de isoxazol-piridina | |
| BRPI0809992A2 (pt) | Derivados de pirrolopirimidina | |
| BRPI0820113A2 (pt) | Derivados de isoxazolo-piridazina | |
| DK2308877T3 (da) | Imidazopyridin-2-on-derivater | |
| BRPI0813836A2 (pt) | Derivados pirazólicos | |
| BRPI0817935A2 (pt) | Derivados de biarila | |
| ATE518837T1 (de) | Indazolamidderivate | |
| ATE545417T1 (de) | Pyrazoloä3,4-büpyridin-derivate als phosphodiesterasehemmer | |
| ATE506358T1 (de) | 2-benzylpyridazinonderivate als met-kinasehemmer | |
| BRPI0814236A2 (pt) | Derivados de quinazolinamida | |
| BRPI0820649A2 (pt) | Derivados de isoxazalo-pirazina | |
| DK2152370T3 (da) | Aryletherpyridazinonderivater | |
| DK2275414T3 (da) | Cyclopentylacrylamidderivat | |
| BRPI0917446A2 (pt) | derivados de acilaminobenzamida. | |
| ATE533761T1 (de) | Imidazolidinonderivate | |
| ATE545635T1 (de) | Substituierte n-oxidpyrazinderivate | |
| JP2009543766A5 (ja) | ｍＰＧＥｓ−１阻害剤としての２−アリールインドール誘導体 | |
| BRPI0906714A2 (pt) | Derivados de oxazepinopirimidona heteroarilamida substituídos. | |
| BRPI0913234A2 (pt) | derivados de tiazolilpiperidina |