BR112012014196A2 - agente para prevenir ou melhorar a pigmentação - Google Patents

agente para prevenir ou melhorar a pigmentação

Info

Publication number
BR112012014196A2
BR112012014196A2 BR112012014196A BR112012014196A BR112012014196A2 BR 112012014196 A2 BR112012014196 A2 BR 112012014196A2 BR 112012014196 A BR112012014196 A BR 112012014196A BR 112012014196 A BR112012014196 A BR 112012014196A BR 112012014196 A2 BR112012014196 A2 BR 112012014196A2
Authority
BR
Brazil
Prior art keywords
prevent
agent
atoms
improve pigmentation
carbon atoms
Prior art date
Application number
BR112012014196A
Other languages
English (en)
Other versions
BR112012014196B1 (pt
Inventor
Chihiro Kondo
Takashi Yamasaki
Yuko Saitoh
Original Assignee
Pola Chem Ind Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Chem Ind Inc filed Critical Pola Chem Ind Inc
Publication of BR112012014196A2 publication Critical patent/BR112012014196A2/pt
Publication of BR112012014196B1 publication Critical patent/BR112012014196B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

agente para prevenir ou melhorar a pigmentação. um objetivo da invenção é fornecer uma preparação externa para a pele, preferivelmente, usável para prevenir ou melhorar a pigmentação. o objetivo é obtido através do fornecimento de um agente para prevenir ou melhorar a pigmentação, consistindo de um composto representado pela fórmula geral (1) seguinte, um isômero do mesmo e/ou um sal farmacologicamente aceitável do mesmo, e de uma preparação externa para a pele contendo o mesmo como um componente: em que r~ 1~ representa um grupo aromático não substituído ou um grupo aromático que apresenta qualquer substituinte: r~ 2~ representa um átomo de hidrogênio, um grupo alquila de cadeia linear ou cadeia ramificada que apresenta vários átomos de carbono ou átomos de 1 a 4, ou um grupo acila que apresenta um alquila de cadeia linear ou ramificada que apresenta vários átomos de carbono ou átomos de 1 a 4; e r~ 3~ representa um átomo de hidrogênio ou um grupo alquila de cadeia linear ou cadeia ramificada que apresenta vários átomos de carbono ou átomos de 1 a 4.
BR112012014196-1A 2009-12-16 2010-12-16 Agente para prevenir ou melhorar a pigmentação BR112012014196B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009285001 2009-12-16
JP2009-285001 2009-12-16
PCT/JP2010/072689 WO2011074643A1 (ja) 2009-12-16 2010-12-16 色素沈着予防又は改善剤

Publications (2)

Publication Number Publication Date
BR112012014196A2 true BR112012014196A2 (pt) 2016-05-31
BR112012014196B1 BR112012014196B1 (pt) 2023-10-03

Family

ID=44167394

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012014196-1A BR112012014196B1 (pt) 2009-12-16 2010-12-16 Agente para prevenir ou melhorar a pigmentação

Country Status (17)

Country Link
US (2) US20120258063A1 (pt)
EP (1) EP2514402B1 (pt)
JP (1) JP5746977B2 (pt)
KR (1) KR101877575B1 (pt)
CN (1) CN102711720B (pt)
AU (1) AU2010331250B2 (pt)
BR (1) BR112012014196B1 (pt)
CA (1) CA2784308C (pt)
ES (1) ES2604104T3 (pt)
HK (1) HK1173662A1 (pt)
IL (1) IL220413B (pt)
MX (1) MX341841B (pt)
MY (1) MY179437A (pt)
RU (1) RU2564897C2 (pt)
SG (1) SG181702A1 (pt)
UA (1) UA111709C2 (pt)
WO (1) WO2011074643A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5908678B2 (ja) * 2011-06-14 2016-04-26 ポーラ化成工業株式会社 皮膚外用剤
JP6255154B2 (ja) * 2012-12-10 2017-12-27 ポーラ化成工業株式会社 皮膚外用剤
JP6249598B2 (ja) * 2012-12-10 2017-12-20 ポーラ化成工業株式会社 皮膚外用剤
CA3185776A1 (en) * 2014-04-03 2015-10-08 Pola Chemical Industries, Inc. Melanogenesis inhibitor comprising d-pantothenyl alcohol, and skin-whitening cosmetic containing same melanogenesis inhibitor
KR101651605B1 (ko) * 2015-12-10 2016-08-26 대봉엘에스 주식회사 신규 페놀산류 유도체 화합물, 및 이의 용도
EP3711746A4 (en) * 2017-11-15 2021-08-25 Pola Chemical Industries Inc. OIL BASED COMPOSITION
BR112020023802B1 (pt) * 2018-05-29 2023-10-31 Pola Chemical Industries, Inc Agente iluminador de pele

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3091270B2 (ja) 1990-09-28 2000-09-25 協和醗酵工業株式会社 美白化粧料
JP3736405B2 (ja) * 1992-12-21 2006-01-18 味の素株式会社 アミノ酸誘導体及び抗活性酸素剤
JP3091045B2 (ja) 1993-03-04 2000-09-25 丸善製薬株式会社 皮膚化粧料
GB9703201D0 (en) * 1997-02-15 1997-04-02 Zeneca Ltd Chemical compounds
JPH10298151A (ja) * 1997-04-30 1998-11-10 Japan Energy Corp Ｃ型肝炎ウイルスプロテアーゼ阻害剤
JPH1149630A (ja) * 1997-07-31 1999-02-23 Shiseido Co Ltd 美白用化粧料
JP3545173B2 (ja) * 1997-07-31 2004-07-21 アマノ株式会社 ダクト管用粉塵堆積防止装置
US5882665A (en) * 1997-11-18 1999-03-16 Elizabeth Arden Co., Division Of Conopco, Inc. Phytosphingosine salicylates in cosmetic compositions
US6238655B1 (en) 1997-12-15 2001-05-29 The Gillette Company α-amides of L-amino acid as fragrance precursors
JPH11310510A (ja) 1998-04-27 1999-11-09 Kanebo Ltd 保湿剤並びに皮膚化粧料及び入浴剤
JP2001247443A (ja) 2000-03-08 2001-09-11 Kanebo Ltd 皮膚化粧料
JP2002087928A (ja) 2000-09-18 2002-03-27 Kyowa Hakko Kogyo Co Ltd 化粧用保湿剤および化粧料
AU2003220896A1 (en) * 2002-03-28 2003-11-10 Sumitomo Pharmaceuticals Co., Ltd. Novel heteroaryl compounds
EP2184281A1 (en) 2002-05-29 2010-05-12 Eli Lilly & Company Phenyl-thiophene type vitamin D receptor modulators
CN1675154A (zh) 2002-06-07 2005-09-28 科蒂科股份有限公司 抑制巨噬细胞移动抑制因子(mif)的细胞因子或生物活性的萘衍生物
NZ537301A (en) 2002-06-07 2006-06-30 Cortical Pty Ltd Therapeutic molecules and methods-1
JP4286513B2 (ja) 2002-09-26 2009-07-01 株式会社ファンケル 抗老化用組成物
ES2317076T3 (es) 2003-12-08 2009-04-16 GALDERMA RESEARCH & DEVELOPMENT Derivados bifenilicos utiles como ligandos que activan receptores rar, procedimiento para prepararlos y su utilizacion en medicina humana y en cosmeticos.
DE602005025517D1 (de) * 2004-10-15 2011-02-03 Bayer Healthcare Llc Herstellung und anwendung von biphenyl-4-yl-carbonylaminosäurederivaten zur behandlung von obesitas
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Also Published As

Publication number Publication date
IL220413B (en) 2018-07-31
HK1173662A1 (en) 2013-05-24
EP2514402A1 (en) 2012-10-24
IL220413A0 (en) 2012-08-30
US20120258063A1 (en) 2012-10-11
ES2604104T3 (es) 2017-03-03
RU2012129932A (ru) 2014-01-27
BR112012014196B1 (pt) 2023-10-03
CN102711720B (zh) 2014-08-27
AU2010331250A1 (en) 2012-08-02
CN102711720A (zh) 2012-10-03
CA2784308C (en) 2017-11-28
SG181702A1 (en) 2012-07-30
UA111709C2 (uk) 2016-06-10
WO2011074643A1 (ja) 2011-06-23
JP5746977B2 (ja) 2015-07-08
CA2784308A1 (en) 2011-06-23
MX2012006925A (es) 2012-07-17
KR20120092709A (ko) 2012-08-21
US9414998B2 (en) 2016-08-16
JPWO2011074643A1 (ja) 2013-04-25
RU2564897C2 (ru) 2015-10-10
MY179437A (en) 2020-11-06
KR101877575B1 (ko) 2018-07-12
AU2010331250B2 (en) 2015-07-30
EP2514402B1 (en) 2016-08-31
MX341841B (es) 2016-09-05
US20140322150A1 (en) 2014-10-30
EP2514402A4 (en) 2014-05-28

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/12/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.