BR112017009168A2 - derivado de tionucleosídeo ou sal deste e composição farmacêutica - Google Patents
derivado de tionucleosídeo ou sal deste e composição farmacêuticaInfo
- Publication number
- BR112017009168A2 BR112017009168A2 BR112017009168A BR112017009168A BR112017009168A2 BR 112017009168 A2 BR112017009168 A2 BR 112017009168A2 BR 112017009168 A BR112017009168 A BR 112017009168A BR 112017009168 A BR112017009168 A BR 112017009168A BR 112017009168 A2 BR112017009168 A2 BR 112017009168A2
- Authority
- BR
- Brazil
- Prior art keywords
- salt
- pharmaceutical composition
- thionucleoside derivative
- thionucleoside
- tumor
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 title abstract 4
- 239000005450 thionucleoside Substances 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 abstract 1
- 229960005277 gemcitabine Drugs 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
resumo ?derivado de tionucleosídeo ou sal deste e composição farmacêutica? são divulgados um composto e uma composição farmacêutica que exibem uma eficácia de fármaco excelente contra um tumor em particular um tumor que tem resistência adquirida à gencitabina. especificamente, é fornecido um derivado de tionucleosídeo representado pela fórmula geral [1] (na fórmula, r1 representa um grupo hidroxila que pode ser protegido, um grupo alcóxi c que pode ser substituído, ou semelhantes; r2 representa um grupo alcóxi c que pode ser substituído, um grupo cicloalcóxi c que pode ser substituído, ou semelhantes; e r3 representa um átomo de hidrogênio ou semelhantes); ou um sal deste. além disso, é fornecida uma composição farmacêutica contendo um tal derivado de tionucleosídeo ou um sal deste.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014-222527 | 2014-10-31 | ||
JP2014222527 | 2014-10-31 | ||
PCT/JP2015/080885 WO2016068341A1 (ja) | 2014-10-31 | 2015-11-02 | チオヌクレオシド誘導体またはその塩および医薬組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112017009168A2 true BR112017009168A2 (pt) | 2017-12-19 |
BR112017009168B1 BR112017009168B1 (pt) | 2022-10-04 |
Family
ID=55857673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017009168-2A BR112017009168B1 (pt) | 2014-10-31 | 2015-11-02 | Derivado de tionucleosídeo ou sal deste, composição farmacêutica que compreende o mesmo e uso da dita composição para tratar câncer pancreático |
Country Status (11)
Country | Link |
---|---|
US (2) | US10059734B2 (pt) |
EP (1) | EP3214090B1 (pt) |
JP (1) | JP6353922B2 (pt) |
KR (1) | KR102056135B1 (pt) |
CN (1) | CN107148423B (pt) |
AU (1) | AU2015337512B2 (pt) |
BR (1) | BR112017009168B1 (pt) |
CA (1) | CA2966138C (pt) |
RU (1) | RU2669806C1 (pt) |
TW (1) | TWI678373B (pt) |
WO (1) | WO2016068341A1 (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2883866B1 (en) | 2012-08-13 | 2019-02-27 | FUJIFILM Corporation | INTERMEDIATE FOR SYNTHESIS OF 1-(2-DEOXY-2-FLUORO-4-THIO-beta-D-ARABINOFURANOSYL) CYTOSINE, INTERMEDIATE FOR SYNTHESIS OF THIONUCLEOSIDE, AND METHODS FOR PRODUCING THESE INTERMEDIATES |
TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
WO2016155593A1 (zh) * | 2015-04-03 | 2016-10-06 | 四川科伦药物研究院有限公司 | 4'-硫代核苷的新型化合物及其制备方法、药物组合物和应用 |
RU2752172C2 (ru) | 2016-08-31 | 2021-07-23 | Фуджифилм Корпорэйшн | Противоопухолевый агент, усилитель противоопухолевого действия и противоопухолевый набор |
US10787477B2 (en) | 2016-12-22 | 2020-09-29 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Solid form of 4′-thio-2′-fluoronucleoside phosphamide compound and preparation method therefor and use thereof |
CN111491634A (zh) | 2017-07-31 | 2020-08-04 | 詹纽瑞治疗公司 | 有机磷酸酯衍生物 |
EP3677267A4 (en) * | 2017-09-01 | 2021-06-02 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF TUMORS, METHOD AND USES THEREOF |
MX2018002611A (es) | 2018-01-29 | 2019-07-30 | Fujifilm Corp | Agente antitumoral para cancer del tracto biliar y metodo para tratar cancer del tracto biliar. |
EP3758495A4 (en) * | 2018-03-02 | 2021-12-01 | January Therapeutics, Inc. | COMPOSITIONS OF NANOPARTICLES |
CN112105624B (zh) * | 2018-03-09 | 2023-09-22 | 美迪维尔公司 | 使用(2,2-双羟甲基)亚甲基环丙烷核苷酸治疗癌症 |
KR20210005638A (ko) * | 2018-04-19 | 2021-01-14 | 써던 리서취 인스티튜트 | 암의 치료를 위한 4'-티오-뉴클레오타이드 및 -뉴클레오사이드 전구약물 |
CN112512529B (zh) | 2018-07-27 | 2024-06-18 | 富士胶片株式会社 | 环戊烯嘌呤衍生物或其盐 |
WO2020108343A1 (zh) * | 2018-11-28 | 2020-06-04 | 四川科伦博泰生物医药股份有限公司 | 以4'-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途 |
KR20220039748A (ko) * | 2019-07-30 | 2022-03-29 | 주식회사 피노바이오 | 암 치료용 디뉴클레오티드 화합물 및 그의 의약 용도 |
US11708637B2 (en) | 2019-08-13 | 2023-07-25 | The Regents Of The University Of California | Methods of supporting a graphene sheet disposed on a frame support |
WO2021226559A1 (en) | 2020-05-08 | 2021-11-11 | Tonix Pharmaceuticals, Inc. | Radio-and chemo-protective compounds |
EP4378466A1 (en) | 2021-07-29 | 2024-06-05 | FUJIFILM Corporation | Pharmaceutical composition and anti-tumor agent for tumors that have at least either impaired bap1 or pbrm1 function |
Family Cites Families (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3116282A (en) * | 1960-04-27 | 1963-12-31 | Upjohn Co | Pyrimidine nucleosides and process |
US3243425A (en) | 1962-10-29 | 1966-03-29 | Purdue Research Foundation | Novel sulfur-containing compounds |
JPS53119810A (en) | 1977-03-25 | 1978-10-19 | Mitsubishi Chem Ind Ltd | Preparation of aldehyde chloride |
US4211773A (en) | 1978-10-02 | 1980-07-08 | Sloan Kettering Institute For Cancer Research | 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides |
US4220774A (en) | 1978-10-26 | 1980-09-02 | Omnium Chimique | Vincadifformine synthesis process |
JPS5692239A (en) | 1979-12-27 | 1981-07-25 | Sagami Chem Res Center | Preparation of 5-oxohexyl compound |
US4803272A (en) | 1987-02-24 | 1989-02-07 | E. I. Du Pont De Nemours And Company | S-modified adenosyl-1,8-diamino-3-thiooctane derivatives |
IE74701B1 (en) | 1989-10-04 | 1997-07-30 | Univ Birmingham | Further antiviral pyrimidine nucleosides |
SE9003151D0 (sv) | 1990-10-02 | 1990-10-02 | Medivir Ab | Nucleoside derivatives |
JP3138834B2 (ja) | 1991-12-26 | 2001-02-26 | 生化学工業株式会社 | フコピラノース類縁体の製造方法およびその合成中間化合物 |
GB9218810D0 (en) | 1992-09-04 | 1992-10-21 | Univ Birmingham | Antiviral pyrimidine nucleosides |
US5811408A (en) | 1994-07-12 | 1998-09-22 | Yamasa Corporation | 2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides |
JPH0853490A (ja) | 1994-08-09 | 1996-02-27 | Yamasa Shoyu Co Ltd | 2’−デオキシ−2’,2’−ジハロゲノ−4’−チオヌクレオシド |
ES2182061T3 (es) * | 1996-04-09 | 2003-03-01 | Yamasa Corp | 1 - (2 - desoxi - 2 - fluor-4- tio-beta-d arabinofuranosil)citosina. |
JP4202327B2 (ja) | 1996-04-09 | 2008-12-24 | ヤマサ醤油株式会社 | 1−(2−デオキシ−2−フルオロ−4−チオ−β−D−アラビノフラノシル)シトシン |
US6103707A (en) | 1996-04-09 | 2000-08-15 | Yamasa Corporation | 9-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)purine derivatives |
HUP9601756A3 (en) | 1996-06-25 | 1999-05-28 | Richter Gedeon Vegyeszet | New anticoagulant glycosides and pharmaceutical compositions containing them |
JP4087471B2 (ja) | 1997-03-31 | 2008-05-21 | 大日本印刷株式会社 | 表面プラズモン共鳴バイオセンサー用測定チップ及びその製造方法 |
HUP9702348A3 (en) | 1997-12-04 | 2000-12-28 | Richter Gedeon Vegyeszet | New anticoagulant glycosides and pharmaceutical conew anticoagulant glycosides and pharmaceutical compositions containing them mpositions containing them |
WO1999043690A1 (fr) | 1998-02-25 | 1999-09-02 | Rational Drug Design Laboratories | Compose de l-4'-arabinofuranonucleoside et composition medicinale le contenant |
ATE531376T1 (de) | 1998-07-23 | 2011-11-15 | Southern Res Inst | Verwendung von thioarabinofuranosyl-verbindungen |
WO2001066118A1 (en) | 2000-03-08 | 2001-09-13 | Southern Research Institute | 4'-thio-l-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof |
KR100426030B1 (ko) | 2000-07-22 | 2004-04-03 | (주) 한켐 | 락톤계 당화합물에서의 키랄성 전환방법 |
TWI247609B (en) | 2001-01-23 | 2006-01-21 | Nihon Mediphysics Co Ltd | Agent for diagnosis of tissue proliferation activity or the treatment of proliferative disease |
AU2002322325A1 (en) | 2001-06-22 | 2003-01-08 | Emory University | Beta-2'-or 3'-halonucleosides |
JP2003172990A (ja) | 2001-08-03 | 2003-06-20 | Fuji Photo Film Co Ltd | ハロゲン化銀乳剤及びハロゲン化銀写真感光材料 |
KR20050056194A (ko) | 2002-08-09 | 2005-06-14 | 다이쇼 세이야꾸 가부시끼가이샤 | 선택적인 아릴 5-티오-β-D-알도헥소피라노시드의 제조방법 |
AU2003200960B2 (en) | 2002-09-18 | 2005-01-06 | Mackinnon, Sebastian Mr | System for Ordering, Tracking and Payment of Goods and Services |
WO2004100891A2 (en) | 2003-05-12 | 2004-11-25 | Purdue Research Foundation | Cytotoxic indeno and isoindoloisoquinolones |
EP1630157A4 (en) * | 2003-05-28 | 2007-05-23 | Japan Tobacco Inc | ANTAGONIST OF CASR |
WO2004106352A1 (ja) | 2003-05-29 | 2004-12-09 | Taisho Pharmaceutical Co., Ltd. | アルドヘキソピラノース中間体の製造法 |
GB0317009D0 (en) * | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
JP5379347B2 (ja) | 2003-09-18 | 2013-12-25 | アイシス ファーマシューティカルズ, インコーポレーテッド | 4’−チオヌクレオシドおよびオリゴマー化合物 |
TW200637839A (en) | 2005-01-07 | 2006-11-01 | Taisho Pharmaceutical Co Ltd | 1-thio-d-glucitol derivatives |
JP5317257B2 (ja) * | 2005-02-21 | 2013-10-16 | 塩野義製薬株式会社 | Hivインテグラーゼ阻害活性を有する2環性カルバモイルピリドン誘導体 |
JP2006335737A (ja) | 2005-06-03 | 2006-12-14 | Ihara Nikkei Kagaku Kogyo Kk | ベンゾ[c]ヘテロ5員環化合物の製造方法 |
WO2007056596A2 (en) * | 2005-11-09 | 2007-05-18 | Wayne State University | Phosphoramidate derivatives of fau |
CN101336247B (zh) * | 2005-12-09 | 2013-01-23 | 豪夫迈·罗氏有限公司 | 抗病毒核苷 |
WO2007068113A1 (en) | 2005-12-16 | 2007-06-21 | Mcgill University | 4'-thioarabinonucleotide-containing oligonucleotides, compounds and methods for their preparation and uses thereof |
CN100513395C (zh) | 2006-04-17 | 2009-07-15 | 中国科学院化学研究所 | 一种制备多羟基环状硝酮的方法 |
US7749983B2 (en) | 2006-05-03 | 2010-07-06 | Chimerix, Inc. | Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates |
CN101200463B (zh) | 2007-12-11 | 2011-06-22 | 复旦大学 | 全酰化-4-硫代-d-核糖及其制备方法 |
US8859589B2 (en) | 2008-03-12 | 2014-10-14 | Southern Research Institute | Use of 4′-thio-2′-deoxynucleosides as anti orthopoxvirus agents |
CN101880287B (zh) | 2009-05-05 | 2012-07-25 | 上海医药工业研究院 | 一类四氢噻吩核苷类似物的中间体化合物及其制备方法 |
TWI476204B (zh) | 2009-12-18 | 2015-03-11 | Libramedicina Inc | 製備經取代之1-O-醯基-2-脫氧-2-氟-4-硫-β-D-阿拉伯呋喃糖的製程 |
AP3584A (en) * | 2010-09-22 | 2016-02-09 | Alios Biopharma Inc | Substituted nucleotide analogs |
GB201016855D0 (en) * | 2010-10-06 | 2010-11-17 | Nucana Biomed Ltd | Chemical compounds |
JP5776564B2 (ja) | 2012-01-20 | 2015-09-09 | 日本精工株式会社 | ワーク処理装置、及びワーク処理方法 |
SG10201603288XA (en) | 2012-03-28 | 2016-05-30 | Fujifilm Corp | Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine |
US20140029864A1 (en) | 2012-07-30 | 2014-01-30 | Dror Reif | Compression encoding and decoding method and apparatus |
EP2883866B1 (en) | 2012-08-13 | 2019-02-27 | FUJIFILM Corporation | INTERMEDIATE FOR SYNTHESIS OF 1-(2-DEOXY-2-FLUORO-4-THIO-beta-D-ARABINOFURANOSYL) CYTOSINE, INTERMEDIATE FOR SYNTHESIS OF THIONUCLEOSIDE, AND METHODS FOR PRODUCING THESE INTERMEDIATES |
WO2015125781A1 (ja) | 2014-02-18 | 2015-08-27 | 富士フイルム株式会社 | チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物 |
JP6204223B2 (ja) | 2014-02-19 | 2017-09-27 | 富士フイルム株式会社 | チオピラノース化合物等の製造方法 |
TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
WO2016155593A1 (zh) * | 2015-04-03 | 2016-10-06 | 四川科伦药物研究院有限公司 | 4'-硫代核苷的新型化合物及其制备方法、药物组合物和应用 |
-
2015
- 2015-10-30 TW TW104135717A patent/TWI678373B/zh active
- 2015-11-02 KR KR1020177011667A patent/KR102056135B1/ko active IP Right Grant
- 2015-11-02 EP EP15853887.6A patent/EP3214090B1/en active Active
- 2015-11-02 AU AU2015337512A patent/AU2015337512B2/en active Active
- 2015-11-02 JP JP2016556227A patent/JP6353922B2/ja active Active
- 2015-11-02 RU RU2017114338A patent/RU2669806C1/ru active
- 2015-11-02 CA CA2966138A patent/CA2966138C/en active Active
- 2015-11-02 BR BR112017009168-2A patent/BR112017009168B1/pt active IP Right Grant
- 2015-11-02 CN CN201580058625.6A patent/CN107148423B/zh active Active
- 2015-11-02 WO PCT/JP2015/080885 patent/WO2016068341A1/ja active Application Filing
-
2017
- 2017-04-28 US US15/581,834 patent/US10059734B2/en active Active
-
2018
- 2018-07-17 US US16/037,375 patent/US10385089B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2966138A1 (en) | 2016-05-06 |
CA2966138C (en) | 2020-01-14 |
US20170233429A1 (en) | 2017-08-17 |
WO2016068341A1 (ja) | 2016-05-06 |
US20180319834A1 (en) | 2018-11-08 |
KR102056135B1 (ko) | 2019-12-16 |
US10059734B2 (en) | 2018-08-28 |
EP3214090B1 (en) | 2020-08-19 |
US10385089B2 (en) | 2019-08-20 |
EP3214090A1 (en) | 2017-09-06 |
RU2669806C1 (ru) | 2018-10-16 |
AU2015337512A1 (en) | 2017-05-18 |
BR112017009168B1 (pt) | 2022-10-04 |
KR20170058436A (ko) | 2017-05-26 |
EP3214090A4 (en) | 2017-09-13 |
JPWO2016068341A1 (ja) | 2017-08-10 |
TWI678373B (zh) | 2019-12-01 |
TW201619179A (zh) | 2016-06-01 |
CN107148423A (zh) | 2017-09-08 |
AU2015337512B2 (en) | 2018-09-06 |
CN107148423B (zh) | 2021-07-30 |
JP6353922B2 (ja) | 2018-07-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112017009168A2 (pt) | derivado de tionucleosídeo ou sal deste e composição farmacêutica | |
MX2022010947A (es) | Compuestos arilo o heteroarilo sustituidos con amino como inhibidores de ehmt1 y ehmt2. | |
MX2019007234A (es) | Compuestos heterociclicos sustituidos con amina como inhibidores de ehmt2 y metodos de uso de los mismos. | |
BR112014017749A8 (pt) | Composto alquinilbenzeno 3,5-dissubstituído e sal do mesmo | |
BR112015021983A2 (pt) | compostos heterocíclicos e usos dos mesmos | |
BR112016017747A2 (pt) | Agente de intensificação de efeito de reabilitação pós lesão de nervo compreendendo derivados de éter de alquila ou sal do mesmo | |
BR112016002083A2 (pt) | composto tetrazolinona e uso para o mesmo | |
BR112017027951A2 (pt) | composto inibitório de brk | |
BR112015001121A2 (pt) | composição para controle de doença de planta e aplicação para a mesma | |
BR112018005932A2 (pt) | inibidores de isoindolinona da interação de mdm2-p53 que têm atividade anticâncer | |
MD20150043A2 (ro) | Inhibitori ai histon-demetilazelor | |
BR112014000665B8 (pt) | composto, composição farmacêutica, agente antimicrobiano, e, uso de um composto | |
TN2018000119A1 (en) | Dihydroimidazopyrazinone derivatives useful in the treatment of cancer | |
BR112016007427A2 (pt) | compostos de pirazol-amida e usos dos mesmos | |
CY1121137T1 (el) | Φαρμακευτικα σκευασματα που περιλαμβανουν ανταγωνιστες ccr3 | |
MY167898A (en) | Co-crystals and salts of ccr3-inhibitors | |
MY186547A (en) | 4?-fluoro-2?-methyl substituted nucleoside derivatives | |
NZ748771A (en) | Pharmaceutical compositions comprising nitroxyl donors | |
BR112012032462A2 (pt) | agente antitumoral empregando compostos que, em combinação, têm efeito inibidor de quinase. | |
BR112015026410A2 (pt) | derivados de dolastatina 10 e auristatinas | |
PH12016502130A1 (en) | Novel pyrrolopyrimidine compound or salt thereof, pharmaceutical composition containing same, especially agent for prevention and/or treatment of tumors etc based on nae inhibitory effect | |
AU2017269673A1 (en) | Pyridine dicarboxamide derivatives as bromodomain inhibitors | |
BR112018017303A2 (pt) | composto tipo piridazinona ou seu sal, e herbicida compreendendo o mesmo | |
BR112013017520A2 (pt) | composto bicíclico ou sal do mesmo | |
MX2020007152A (es) | Compuestos heterociclicos sustituidos con amina como inhibidores de ehmt2, sales de los mismos, y metodos de sintesis de los mismos. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/11/2015, OBSERVADAS AS CONDICOES LEGAIS |